MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14461/m_MTBLS14461_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14461/m_MTBLS14461_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14461/a_MTBLS14461_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14461/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14461/a_MTBLS14461_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14461/s_MTBLS14461.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14461<p>At the same time, the metabolites were identified by searching database, and the main databases were the&nbsp;HMDB (http://www.hmdb.ca/), Metlin ( https://metlin.scripps.edu/)&nbsp;&nbsp;and Majorbio Database .</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>The LC-MS/MS analysis of sample was conducted on a Thermo UHPLC-Q Exactive HF-X system equipped with an ACQUITY HSS T3 column (100 mm × 2.1 mm i.d., 1.8 μm; Waters, USA) at&nbsp;Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China). The mobile phases consisted of 0.1% formic acid in water:acetonitrile (95:5, v/v) (solvent A) and 0.1% formic acid in acetonitrile:isopropanol:water (47.5:47.5, v/v) (solvent B). The flow rate was 0.40 mL/min and the column temperature was 40℃. The injection volume was 3 μL.</p>X-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis.Huashan Hospital, Fudan Universitychangyue wuskin fibroblast culturemass spectrometry assay<p> 50 mg sample was added to a 2 mL centrifuge tube and a 6 mm diameter grinding bead was added. 400 μL of extraction solution (methanol: water = 4:1 (v:v)) containing 0.02 mg/mL of internal standard (L-2-chlorophenylalanine) was used for metabolite extraction. Samples were ground by the Wonbio-96c ( Shanghai wanbo biotechnology co., LTD) frozen tissue grinder for 6 min (-10°C, 50 Hz), followed by low-temperature ultrasonic extraction for 30 min (5°C, 40 kHz). The samples were left at -20°C for 30 min, centrifuged for 15 min (4°C, 13000 g), and the supernatant was transferred to the injection vial for LC-MS/MS analysis.</p>Homo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS14461changyue wu. Huashan Hospital. wcylaiyuehao@163.com.<p>The pretreatment of LC/MS raw data was performed by&nbsp;Progenesis QI (Waters Corporation, Milford, USA)&nbsp;software, and a three-dimensional data matrix in CSV format was exported. The information in this three-dimensional matrix included: sample information, metabolite name and mass spectral response intensity. Internal standard peaks, as well as any known false positive peaks (including noise, column bleed, and derivatized reagent peaks), were removed from the data matrix, deredundant and peak pooled.&nbsp;</p>Treatmentwcylaiyuehao@163.com<p>KF:&nbsp;Primary keloid fibroblasts without treatment;&nbsp;KF_IR:&nbsp;Primary keloid fibroblasts at 72 hours after treatment with 8 Gy X-ray irradiation;&nbsp;NF:&nbsp;Primary normal skin fibroblasts without treatment. Each group contained 8 replicate samples. For each sample, cells from one large culture dish were collected, yielding approximately 4 × 1000000 cells.</p>MetabolomicskeloidThermo Scientific Vanquish UHPLC SystemMetabolomicsuntargeted analysisThermo Scientific Q Exactive HF-XHomo sapiensexperimental blankKIF20Acell cycle arrestphytosphingosineuntargeted metabolite profilingskin fibroblast culturekeloidThermo Scientific Vanquish UHPLC SystemMetabolomicsuntargeted analysisThermo Scientific Q Exactive HF-XHomo sapiensexperimental blankKIF20Acell cycle arrestphytosphingosineuntargeted metabolite profilingskin fibroblast culture<p> The mass spectrometric data were collected using a Thermo UHPLC-Q Exactive&nbsp;HF-X&nbsp;Mass Spectrometer equipped with an electrospray ionization (ESI) source operating in positive mode and negative mode. The optimal conditions were set as followed: source temperature at 425℃; sheath gas flow rate at 50 arb; Aux gas flow rate at 13 arb; ion-spray voltage floating (ISVF) at -3500V in negative mode and 3500V in positive mode, respectively; Normalized collision energy , 20-40-60V rolling for MS/MS. Full MS resolution was 60000, and MS/MS resolution was 7500. Data acquisition was performed with the Data Dependent Acquisition (DDA) mode. The detection was carried out over a mass range of 70-1050 m/z.</p>Phe Thr4-HydroxynonenalIsoleucyl-Tyrosine3-Methylglutaconic AcidPe(18:1/0:0)Argininosuccinic AcidXestoaminol CSerylthreoninePc(34:2)ProlylprolineN,N-Dimethyltetradecylamine-N-OxideIndolylacryloylglycine2,3-DiaminopyridinePc(P-16:0/18:1(12Z)-2Oh(9,10))L-Histidine3-O-Demethylfortimicin A3-HydroxypyridineManoyl Oxide1,1'-Oxalyldiimidazole1,5-Naphthalenediamine2,3-Butanediol GlucosideArachidonoyl Paf C-16CnidilideTrp Gln(+/-)-(Z)-2-(5-Tetradecenyl)CyclobutanoneSer PheDelta-ValerobetaineAsp Trp4-HydroxybenzaldehydeTrans,Trans-2,4-HeptadienalFurfuralLauryl Diethanolamide2-Methylbenzoic AcidHexamethylene TetramineAsn ThrJasmoneN-Cyclopropyl-4-[[1-(3-Methylbutanoyl)Piperidin-4-Yl]Methoxy]BenzamideGlu Val7-Hydroxy-2,5-Dimethyl-4H-1-Benzopyran-4-OneHexamethoxymethyl MelaminePc(16:0/15:0)2-Hydroxy-3-Methoxybenzyl Alcohol7-Hexadecenoic Acid Methyl EsterIsoferulic Acid(2Xi,4Xi)-2,4-Nonadien-1-Ol9,9-Dimethyl-1-(Sulfinylamino)DecaneIle TrpN-CyclohexanecarbonylpentadecylamineKessaneSm(D18:1/24:1)DiglykokollAdenosine MonophosphateHexadecylamineGamma-Glutamylthreonine4-MethylstyreneIsophoroneN-Methyl-L-Glutamic AcidOleamideCinnamic AcidMethionyl-ProlinePenicillic AcidN-[(3,4,5-Trimethoxyphenyl)Methyl]-2-(3,3,5-Trimethyl-2-Oxoindol-1-Yl)AcetamideSalicylaldehyde(E)-6,10-Dimethyl-9-Methylene-5-Undecen-2-One(Z)-9-Cycloheptadecen-1-OneSn-Glycero-3-Phosphocholine7-KetocholesterolRitalinic Acid3,5-Di-Tert-Butyl-4-Hydroxybenzyl AlcoholDihydro-Alpha-Ionone(E)-2,6-Dimethyl-2,5-Heptadienoic AcidMyrceneBenzocaineGpcho(18:2/16:1)Tiazofurin19-NortestosteroneProcyclidineLysope(20:4(8Z,11Z,14Z,17Z)/0:0)Asn GluTrp ThrGlycylvalineGly-Ile(2-Mercaptomethyl-3-Phenyl-Propionyl)-GlycineAla Val Val1-Oleoyl-2-Palmitoyl-Sn-Glycero-3-PhosphocholineOrnithineLys SerLeu GlyLeu Pro TyrHydroxylated LecithinIndoleN-Nervonoyl CysteineDextromethorphanMg(0:0/18:1(11Z)/0:0)Trp Gly[16]-GingerolBenzamideN-Acetyl-D-GalactosaminePhthalic AnhydrideButyraldehydeAlpha-IononeLeu Glu3,4-Edma3-Hydroxy-Hexanoyl-Dl-Homoserine LactoneAdenosineSer TrpIle Asp GlnPc(P-16:0/20:4(8Z,11Z,14Z,17Z))Penicillanic AcidBis(2-Ethylhexyl) PhthalateOleoyl-L-Carnitine2-N-Propylthiazolidine-4-Carboxylic AcidPc(34:1)(3S)-3,7-Diaminoheptanoic Acid1,3-BenzodioxolylbutanamineIsoketocamphoric AcidP-HydroxyubenimexButyryl Trihexyl CitrateDodecanamide3,5-Di-Tert-Butyl-4-HydroxybenzaldehydeTrp-GluIsoproterenolMyristoyllysophosphatidylcholineN-Chlorophenylalanine9-Oxohexadecanoic AcidPectenotoxin 33-DehydrosphinganinePro-Pro-ProSphingosineAsp Ile Val4-Hydroxy Nonenal Alkyne9(Z),11(E)-Conjugated Linoleic AcidSm(D18:1/16:0)Asn Trp1,4-DiaminobutanePhosphatidylcholine Alkyl 16:0-22:66-Hydroxycaproic AcidPyr-Phe-OhZeatinO-Xylene5-Methyl Furfural(E)-Hept-3-EneCabergoline2-(4-Hydroxyphenyl)Naphthalic AnhydrideSpinosin1-Phenoxy-2-PropanolMycorradicinAsp TyrTrans-3-Indoleacrylic AcidDelta-ValerolactoneJasmonic AcidGuanineSerratol4-Amino-4-DeoxychorismateOleyl AlcoholViolet-Leaf AldehydeAsn PheMg(18:1(9Z)/0:0/0:0)Dg(18:0/20:4(5Z,8Z,11Z,14Z)/0:0)Indole-3-CarboxaldehydeSer GluAcetanilideLysopc(18:3(6Z,9Z,12Z)/0:0)Caryophyllene Oxide(S)-2,3-Dihydro-5-Hydroxy-2-Methyl-1,4-NaphthoquinonePc(O-18:0/0:0)7-MethylguanineXi-4-Hydroxy-4-Methyl-2-Cyclohexen-1-OneAmbronide2-ChloroacetophenoneGly Val Thr3,6,9,12,15,18,21,24,27,30-Decaoxadotriacontane-1,32-DiolGlucose-Uridine-C1,5'-DiphosphateL-Hexanoylcarnitine4-Hydroxy-4-Methyl-5-Hexenoic Acid Gamma LactoneLysope(0:0/22:5(7Z,10Z,13Z,16Z,19Z))OctadecanolPyroglutamylprolineTanacetol B6-Hydroxypentadecanoylcarnitine3-Methylsalicylic AcidArachidoyl EthanolamideIsoleucyl-GlutamateFa(18:3+1O)Pc(22:4(7Z,10Z,13Z,16Z)/P-18:0)Lysylisoleucine2,3-ButanedioneAlpha-IroneAsp Arg2-Azaspiro[4.5]Decan-3-One1,25-Dihydroxy-16-Ene-23-Yne-Vitamin D31,4-IpomeadiolGpetn(14:0/22:1)Gly PheTrp AlaPc(17:0/0:0)1-Palmitoyl-Sn-Glycero-3-PhosphocholineAmbiosoneCarnitineGlutamic AcidHydroquinoneAustinoneolTrihydroxycoprostanoic AcidBenzofuranVal Thr TrpFloionolic AcidMuramic AcidVal ValGpetn(14:0/22:2)(2R)-1-(4-Nonylphenyl)Propan-2-AminePhe GlnSn-Glycero-3-PhosphoethanolamineKapaSm(D18:1/20:4(8Z,11Z,14Z,17Z)-2Oh(5S,6R))7-Methyl-9-Piperidin-4-Ylpurin-8-One4-Methyl Pv82-Methoxy-5-Methyl-3-(2-Methylbut-3-En-2-Yl)Chromen-4-OnePhe GlyPc(36:2)SafroleAsp LeuAlpha-Terpinene4-Amino-3-Hydroxybutyric AcidPi(16:0/22:4(10Z,13Z,16Z,19Z))5-(Delta-Carboxybutyl)Homocysteine1,2-Dioleoyl-Sn-GlycerolIle Glu3-KetosphingosineGpcho(20:2/16:1)HydroxyamphetamineIle GlyValylglutamic AcidIsonicotinic Acid3,8-Dimethyl-7,8,9,10-Tetrahydro-6-Thia-1,2,3A,5-Tetraaza-Cyclopenta[C]FluoreneAla HisDeoxycholylarginine4-HydroxyisoleucineCyclohexanecarboxamideSarcosineIle GlnDihydrocarvonePc(18:0/20:3(8Z,11Z,14Z))Epothilone AGamma-Glu-Leu3-PhosphoglycerateDipentyl PhthalateAsp Ile GluAsp Asn IleGeldanamycinS-Prenyl-L-CysteineSer Pro ThrN,N-DimethylguanosineDibutyl SebacateLongicamphenyloneHydroxyisovaleroyl CarnitineN,N-Dimethyldodecylamine-N-OxideNerolidolL-Threonine6-Oxopiperidine-2-Carboxylic AcidRicinoleic AcidPiperonyl Butoxide2-Acetoxy-6-Pentadecylbenzoic Acid1-[[3-(4-Chlorophenyl)-1,2,4-Oxadiazol-5-Yl]Methyl]-4-Phenylpyrazine-2,3-DioneHis LeuL-LeucineTrigonellinePyridoxal1-Methyl-4-Methylidene-7-Propan-2-Yl-2,3,3A,5,6,8A-Hexahydroazulen-1-OlTrp LeuBeta-Phenyl-Gamma-Aminobutyric AcidN-Stearoyl GlutamineThr SerCyclohexa-2,4-DienylmethanolEdetic AcidDiacereinGpcho(18:1/16:1)Arg Ala11-Meo-Fes1-Oleoyl-2-Myristoyl-Sn-Glycero-3-PhosphocholineN,N-Diacetyl-O-Methylhydroxylamine2-Amino-3-Methoxybenzoic Acid1-MethylguanosineA-PyrrolidinohexanophenoneGeranylgeraniolArachidonoylcarnitine(-)-Alpha-CedrenePenicillin G2,4-Dihydroxy-2,5-Dimethyl-3(2H)-FuranonePro Ile GluKojic Acid3-Hydroxynonanoyl CarnitineOctopamineL-Tryptophan2-Trans-6-Cis-DodecadienalOctahydro-2H-1-Benzopyran-2-OnePc(15:0/16:0)8-Amino Caprylic AcidProlylhydroxyprolinePyrogallolValylmethionine10,20-Dihydroxyeicosanoic Acid2,3-Dimethyl-2-Cyclohexen-1-OneIle IleAzacyclotridecan-2-OnePc(22:4/0:0)L-ValineUracil25,27-Dihydro-4,7-Didehydro-7-Deoxyphysalin APro ArgPhloroglucinol1-Methylbenzotriazole(1'R)-Nepetalic AcidCreatineTris(1-Chloro-2-Propyl) PhosphateOphthalmic Acid1-Palmitoyl-2-Myristoyl-Sn-Glycero-3-Phosphocholine9,10-Dihydroxystearic AcidAsp Ile IleTyrosine-Tyrosinate4-Methylcatechol 2-GlucuronideCytosineGln AlaLaurocapramTrp AspPc(O-16:0/20:4(8Z,11Z,14Z,17Z))Asp Val LeuL-CystineGoshuyic AcidPhe Val2-Methoxyestrone 3-GlucuronideVal GlyGln Trp12-Methyltridecanoic AcidPc(16:1/0:0)Gamma-GlutamylphenylalanineGluconolactoneGpetn(14:0/24:4)Dl-EthionineIreneMyristoyl EthanolamideGlycylmethionineOctaethylene GlycolVernolic Acid.Alpha.-(Methoxymethyl)-2-Nitroimidazole-1-EthanolPv9Choline PhosphatePe(P-18:0/0:0)Cdp-CholineDiallyl TrisulfideMethylene BisacrylamideArctiolAsn LeuGpcho(17:1/15:0)N-Lactoyl-PhenylalanineAlcoifosfamideIle ValAla-Ala-AlaPyroglutamyl-Glutamyl-Proline AmideVal Asn TyrDodecylbenzeneChlorfenetholGly Asp LeuLimonene Oxide4-Hydroxy NonenalDeoxycholic Acid Methyl EsterPc(20:0/20:3(6,8,11)-Oh(5))12-Keto-Leukotriene B4Orotidylic AcidGpcho(18:1/18:2)EthylbenzenePe-Nme2(22:5(7Z,10Z,13Z,16Z,19Z)/20:3(8Z,11Z,14Z))Creatinine AspartateDimethyl SulfoxideP-Tolualdehyde(6E,8E,10S,12Z)-10-Hydroxy-3-Oxooctadecatrienoic AcidTyraminePe(21:0/0:0)Pyroglutamic Acid(R)-1-O-[B-D-Apiofuranosyl-(1->2)-B-D-Glucopyranoside]-1,3-Octanediol5-Methyl-1H-Benzotriazole5,7Alpha-Dihydro-1,4,4,7A-Tetramethyl-4H-IndeneLeu Ser3-Hydroxyundecanoic AcidDihydrojasmoneDecylamine OxideValtrateOctanoate2-Undecyl-Thiazolidine-4-Carboxylic AcidGlycerophosphocholineHesperidinNorfenefrineDecanophenone10-Hydroxy-2E-Decenoic AcidLyso-Paf C-189,10,13-Trihydroxystearic AcidDg(18:0/20:4(8Z,11Z,14Z,17Z)/0:0)Ser LeuTyr-Pro2-Aminooctanedioic AcidTargininePc(16:1(9Z)/15:0)KynurenineDg(18:1(11Z)/18:0/0:0)AsparaginylcysteineN-Ethyl-N-Methylcathinone7-EthylguanineBenzylideneacetoneN-Hydroxy-L-TryptophanLysope(0:0/22:4(7Z,10Z,13Z,16Z))Lysops(18:0/0:0)Ile-MetPe(P-18:0/22:5)O-Acetylcarnitine12-[(Cyclohexylcarbamoyl)Amino]Dodecanoic AcidGpcho(18:1/18:1)L-GlutamineCholineS-Ethyl-L-CysteineN-MethylphenylalanineAldobiouronic Acid D32-(2-Butoxyethoxy)Ethanol(12Z)-10-HydroxyoctadecenoylcarnitineL-Menthyl (R,S)-3-HydroxybutyrateAurinGpcho(16:1/16:0)Nonadecanoic AcidCyanthoatePe(P-18:0/20:4)Diethyl PhthalateCoronaric Acid8-(3-Oxo-2-(Pent-2-Enyl) Cyclopentenyl)Octanoic AcidIndolineTirofibanLarixinic Acid15,16-Dihydroxyoctadeca-9,12-Dienoic Acid2-Cyclotetradecen-1-One2-Hydroxyphenylacetic AcidDl-ArginineGpcho(20:1/20:4)Carvone2-Cyclooctyl-2-Hydroxyethylamine2-AminopurineHydrocodonePc(15:0/0:0)Gly IleArg LeuPalmitoylcarnitine6-(3-Hexenyl)Tetrahydro-2H-Pyran-2-One5-Hydroxyindoleacetic AcidS-Butylcysteine SulfoxideLyso-Pc(18:0)Pe(18:3(9Z,12Z,15Z)/18:1(9Z))5-Hydroxy-N-FormylkynurenineCepageninHeptadecasphinganine4'-Methylacetophenone2-Linoleoyl Glycerol1-Octylpyrrolidin-2-OneGpetn(12:0/24:1)Epigallocatechin2-Deoxycastasterone5-Hydroxyvalproic Acid3-Methylpyrrolo[1,2-A]PyrazineMdpbpN-Cyclohexylformamide2-Aminobicyclo[3.1.0]Hexane-2,6-Dicarboxylic AcidDihydrothymine(3E,5E)-1,3,5-OctatrienePiperidineEthoxyquinIle Val GlyL-CoprineHomomethionineP-Mentha-1,3,8-TrienePc(P-18:1(11Z)/18:1(12Z)-2Oh(9,10))Thr His4-HeptylphenolOctadeca-9,12-DienalPe-Nme(20:0/16:0)4-Chlorophenyl2-Aminoacetophenone28-HomobrassinolideL-Aspartyl-L-PhenylalanineG-Glu-ValGpcho(18:3/20:1)5-Nitro-2-(3-Phenylpropylamino)Benzoic AcidGpcho(16:0/20:5)Aspartame4-PiperidinecarboxamideAsp Met3-Amino-2-Methoxynonadec-5-En-4-OlN-[(2-Methoxypyridin-3-Yl)Methyl]Thiophene-2-CarboxamideChandalonePhe LysChlorobenzeneAsp Ser LeuTrans-Zeatin-O-Glucoside RibosideTropinoneAnisperimusN2-MethylguanosineL-ProlineN-Lactoyl-MethioninePhenolLaminine2-MethylbutyroylcarnitineTridecanol5-(Hydroxyphenyl)-Gamma-Valerolactone-O-SulphatePc(18:1/0:0)L-Tert-Leucine1-HexadecanolTetrahydropyran-2-MethanolAsp Ile AspVal ArgSm(D18:0/16:1(9Z))Glu Leu AlaGlucose 1-PhosphateAsp Ile AsnPc(O-18:1(9Z)/20:4(8Z,11Z,14Z,17Z))ButyrylcarnitinePhthalic AcidL-AsparagineAlpha-CurcumeneCystathionine3,4-DimethylstyrenePerillyl Alcohol(R)-2-Amino-3-(2-Propynylthio)Propanoic AcidMevalonolactoneGalaxolidone5-(2-Nitroprop-1-Enyl)-1,3-BenzodioxoleLys GlyGpser(14:0/22:1)Thr LeuFusaric AcidAceclidineCyclohexenylCyclopropyl Fentanyl1,9-DimethylguanineFarnesol2-Amino-3-Cyclohexylpropanoic AcidNona-2,4,6-Trienal4,7,13,16,21,24-Hexaoxa-1,10-Diazabicyclo[8.8.8]HexacosaneGlu ArgBis(2-Ethylhexyl) AdipateVal Leu1-Cyclohexyl-3-[[1-(Hydroxymethyl)Cyclopropyl]Methyl]UreaD-Gulono-1,4-LactoneLysopa(22:5(7Z,10Z,13Z,16Z,19Z)/0:0)ExalamideGpcho(18:0/18:2)Glucosaminic AcidN-(2-Hydroxyethyl)Iminodiacetic Acid2-Aminooctadec-4-Yne-1,3-DiolP-Coumaryl Alcohol 4-O-GlucosidePhosphoribosylformylglycinamidine2-Methoxybenzoic AcidAsp Ile AlaPenicilloic AcidGln IleArabinofuranosylguanineGpcho(22:6/20:2)Gpetn(16:1/22:4)(E)-5,8-Megastigmadien-4-One1-Aminocyclopropanecarboxylic AcidPc(P-16:0/22:4)Pc(P-18:0/16:0)FenvalerateHomocystamine2-MethylindoleHt-2 ToxinRioprostilPe(19:1(9Z)/0:0)7-Hydroxychroman-2-One1-Indanone5-Hete Lactone2-HydroxymyristoylcarnitineEpicillinGeranylcitronellolDihydroceramide C2Asparagine Propyl EsterDesethylenenorfloxacin8,11-Heptadecadienal(9R,10S)-DihydroxystearateGpcho(20:4/18:1)4-Oxo-2-NonenalIsoindolinePc(16:0/P-16:0)3,4-DihydroxybenzaldehydeDiethanolamineDihydroxyphenyl-ValerolactoneSwainsonineLeucyl-GlutamateThiamineArachidyl Alcohol5-Hydroxymethyl-2-Furancarboxylic AcidCorchorusoside EAcetyl Tributyl CitrateN,N-Diisopropylethylamine4-EthynylanilineAlpha-Methylene-Gamma-ButyrolactoneGlu AspTetradecyldiethanolamineAcetylphosphateKetoisophoronePc(18:2/0:0)Methyl 3-Methyl-1-Butenyl Disulfide6-Phosphonoglucono-D-Lactone2-Methyl-1,3-CyclohexadieneJasmine LactoneN-MethylvalinePc(20:4/0:0)Acetoacetic AcidL-TyrosinePro LysGpcho(20:4/18:0)Linoleic Acid4-Methyl-1H-BenzotriazoleLysope(0:0/18:0)7A,12A-Dihydroxy-Cholestene-3-OneLevofloxacinPhe-ProN-[Bis(3-Aminopropyl)Amino]-N-Hydroxynitrous Amide4-Hydroxyphenylacetic AcidTrihexyphenidylPe-Nme2(14:1(9Z)/20:0)GlycylprolineN-Isobutyloctadeca-Trans-2-Trans-4-Dienamide2-C-Methyl-D-Erythritol-2,4-CyclodiphosphateL-Erythro-4-Hydroxyarginine3-AminopropionaldehydeSpermidine2,5-DihydroxybenzaldehydeDg(6 Keto-Pgf1Alpha/I-19:0/0:0)(3Z,6Z)-3,6-Nonadienal2-Hydroxycinnamic AcidSorbic Acid(-)-Corey Lactone DiolN-(2,14-Eicosadienoyl)PiperidineLeu Arg6-MethoxymelleinMycolactoneDomM-XyleneN-PalmitoylsphingosineProlyl-MethioninePropionylcarnitineKaempferol 3-(2G-Apiosylrobinobioside)Ser Ser8-Oxohexadecanoic Acid3-Tert-Butyladipic AcidClenproperolAspartic Acid Methyl EsterGln GluAla-Cys-Gly2-Amino-2-Methyl-1-PropanolGln Gly1-(1-(3-Methoxyphenyl)Cyclohexyl)PiperidineN-(2-Oxooxolan-3-Yl)TetradecanamideTramadol N-OxidePc(22:1(13Z)/18:4(6Z,9Z,12Z,15Z))BenzyldimethyltetradecylammoniumN-(3-Chloro-4-Methylphenyl)-2-(5-Pyrazin-2-Yl-1,3,4-Oxadiazol-2-Yl)AcetamideOctadecanamideCyclohexanoneCysteine-Glutathione DisulfideD-Pyroglutamic AcidBenzoic AcidPc(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/P-16:0)Delta-HexalactoneAcetophenonePe(P-16:0/0:0)CreatinineVaccenic AcidN-Cyclohexylidene-2-Carbamylcyclohex-1-Enylamine4-VinylcyclohexenePyridoxine2-PhenylacetamideN,N-DimethylformamideGalaxolide5'-Deoxy-5'-MethylthioadenosineLysopc(15:0)N-Stearoyl ArginineNad+Alanine-Betaxanthin4'-HydroxyclobazamPe(36:2)Cucurbic AcidSer Gly ValThr Trp3-Methyl-1-Butylamine2-Aminoindan-2-Carboxylic AcidCinobufagin4-Octylphenol5-Fluorouridine(1R,3S)-3-(6-Aminopurin-9-Yl)Cyclopentan-1-OlBetaine(E)-Ethenoxyimino-Oxido-Pyrrolidin-1-YlazaniumPipecolic AcidBenzoic AldehydeN-Epsilon-Acetyl-L-LysineGrayanotoxin(S)-A-Amino-2,5-Dihydro-5-Oxo-4-Isoxazolepropanoic Acid N2-Glucoside7',8'-Dihydro-8'-HydroxyreticulataxanthinEthoxycarbonylmethyl Ethyl PhthalateL-LysineCapsiamideGalactosylhydroxylysineEthylmorphineN-Benzylformamide5-Hydroxymethyl-2-FuraldehydeCys-Gly(+/-)-Propionylcarnitine2,2,7,7-Tetramethyl-1,6-Dioxaspiro[4.4]Non-3-EneNorethindroneN-Alpha-AcetyllysineThr Phe4-Hydroxy-3-MethoxybenzenemethanolVerbenalol2-CyclohexylidenecyclohexanonePhe SerIsoleucyllysine4-Butylmorpholine(3E,7E)-4,8,12-Trimethyl-1,3,7,11-Tridecatetraene22-Hydroxydocosanoic Acid4'-Hydroxy-R-PhenprocoumonCamphorN-(6-Cyano-3-Hydroxy-2,2-Dimethyl-3,4-Dihydrochromen-4-Yl)-N-MethylethanesulfonamideAla IlePhe AsnVelvionePc(38:6)Trp Ala ArgD-Fructose1,5-AnhydroglucitolEicosadienoic Acid2-MethylpyrrolidineGpetn(14:1/20:0)Thr GlyGpcho(20:1/18:3)4-(4-Ethylanilino)-N-(2-Methoxyethyl)Quinazoline-2-CarboxamideTrans-Zeatin Riboside MonophosphatePro Lys TyrLoxoribineThr GluNoradrenalineThr GlnEpinepetalactone1,2-BenzoquinonePalmitoylethanolamideSenecioic Acid1-Stearoyl-2-Linoleoyl-Sn-Glycero-3-PhosphatidylcholineN-Stearoyl Tryptophan1-O-Isopentyl-3-O-Octadec-2-Enoyl Glycerol2,3-Dihydroxypropyl Dodecanoate11-Aminoundecanoic AcidLauroylcarnitineCysteinyl-AsparagineThiomorpholine 3-Carboxylate3-GonalArachidic Acid1,2,10-Trihydroxydihydro-Trans-Linalyl Oxide 7-O-Beta-D-Glucopyranoside4-Fluoro-L-PhenylalanineStyrene5-Isopropylbicyclo[3.1.0]Hexan-2-One12-EpinapellineGpetn(18:3/20:1)P-Coumaroyltriacetic Acid LactoneButylisopropylamine2-(Ethoxymethyl)FuranGlu Thr Arg2,4-Dihydroxy-7,8-Dimethoxy-2H-1,4-Benzoxazin-3(4H)-One 2-GlucosidePhenylacetoneLauryldiethanolamine13,14-Dihydro Pgf-1ALinoleamideP-Mentha-1,3,5,8-TetraeneNonactinic AcidL-NorleucineAsp Ile Ser2-(Methylthio)BenzothiazoleTenuazonic AcidDihydrozeatin1-(2,3,8,8-Tetramethyl-1,2,3,4,5,6,7,8-Octahydronaphthalen-2-Yl)Ethanone4-DodecylmorpholineApo-14'-ZeaxanthinalMeteneprostEstranePe(19:0/0:0)Indene5-Ethyl-2-MethylpyridinePaullinic AcidSer ValLeucylprolineFarnesyl AcetoneN-[2-(2-Pyridinyl)Ethyl]-3,4-Dihydro-2H-1,5-Benzodioxepine-7-SulfonamideEtaspireneCc12C(Cc(Cc1)C2(C)C)=Cc(O)NPhytosphingosineN6-(L-1,3-Dicarboxypropyl)-L-Lysine3-O-Alpha-D-Glucopyranuronosyl-D-Xylose1-Hexadecyl-2-(9Z-Octadecenoyl)-Sn-Glycero-3-PhosphocholineGlu Glu5'-Guanylic AcidCeanothine ECoumarinLysopa(I-19:0/0:0)6-Hydroxy-2-AminopurineHis Trp Phe5,6,7,8-Tetrahydro-2-Naphthoic AcidSalicyclic AcidLysopc(20:3(8Z,11Z,14Z)/0:0)Doet3,4-Dihydroxy-2-Hydroxymethyl-1-PyrrolidinepropanamideGly TyrN-Lauroyl Arginine3-(6-Aminopurin-9-Yl)-5-(Hydroxymethyl)Cyclopentane-1,2-Diol3-Hydroxyphenylacetic AcidAsp ValBeta-D-Ribosylnicotinate(2S)-2-(4-Chloroanilino)Propanoic AcidN-(4-Hydroxyphenyl)-Eicosa-5,8,11,14-TetraenamideL-Cysteine, N-Acetyl-, Ethyl EsterAlpha-PyrrolidinopropiophenoneAdenineLeu LeuTimonacicTuberculostearic Acid3-(3-Indolyl)-2-Oxopropanoic AcidL-Serine7-Hydroxy-2-Methyl-4-Oxo-4H-1-Benzopyran-5-Carboxylic Acid 7-GlucosideLumichromeNaratriptanDl-O-Tyrosine(3S,5R,6R)-3,5-Dihydroxy-6,7-Didehydro-5,6-Dihydro-12'-Apo-Beta-Caroten-12'-AlPr DipeptideLeu Thr1-(2,6,6-Trimethyl-2-Cyclohexen-1-Yl)-1,6-Heptadien-3-OneGonal4-Hydroxy-2,6-DimethylanilineAsparagine-BetaxanthinPhytantriolTyr Ile3-Hydroxy-N-(2-Oxooxolan-3-Yl)Hexanamide2,5-DimethylbenzaldehydeDihydrostreptomycinMyristoylcarnitineAlliinGlu TrpN'1-(2-Cyano-3-Fluorophenyl)-N'1-MethylethanimidohydrazidePhe AlaPe(16:0/0:0)Bis(2-Ethylhexyl) SebacateIle Asn1-[2-(4-Ethylpiperazin-1-Yl)Pyrimidin-5-Yl]-N-Propylpiperidine-4-CarboxamideL-MethionineLeu Pro LeuN-Oleoyl ArginineMethyldopaNicotinamideTrp ValGlycyl-LeucineN-LactoylleucineO-(17-Carboxyheptadecanoyl)CarnitineT-4-Aminocrotonic Acid (Taca)3-Methylsuberic Acid3-Hydroxycotinine GlucuronideDodemorph(S)-Oleuropeic AcidTributyl Citrate2-Propyl-N-[2-(4-Pyridin-2-Ylpiperazin-1-Yl)Sulfonylethyl]Pentanamide1,2,3,4-Tetramethyl-1,3-CyclopentadieneTridemorphMethionine SulfoxideMenthyl Ethylene Glycol CarbonateEcdysoneGpetn(18:4/3:0)4-Chloro-L-Phenylalanine2-Amino-4-Oxo-6-(1',2'-Dioxoprolyl)-7,8-Dihydroxypteridine5-(Hydroxymethyl)-4-Methoxy-2(5H)-FuranoneAsp Asp LeuPhysagulin AButyryl CarnitineProline BetaineS-Adenosylmethionine13,14-Dihydro-15-Keto-Pge2FraxinPentenylbenzeneL-Alanyl-L-Proline4-Amino-5-Hydroxymethyl-2-Methylpyrimidine(+/-)-PelletierineEthyl LinolenateCyclohexanecarboxylic Acid(2S,3R)-2-Amino-4-Octadecene-3-OlAla PheLys AlaHis IleTyr Glu1,4-Butanediol Diglycidyl EtherTriphenylphosphine OxideTranexamic AcidNicotinamide D-RibonucleotideS-Adenosyl-L-Homocysteine2-Hydroxy-2,6,6-Trimethylcyclohexanone2,6-Di-Tert-Butyl-1,4-Benzoquinone2-Cyclopenten-1-OneGlu PheLaccer(D18:1/16:0)(4S,8R)-8,9-Dihydroxy-P-Menth-1(6)-En-2-OneIcosa-5,8,11,14-Tetraene11-Hydroxy-9-Tridecenoic Acid1-(Beta-D-Ribofuranosyl)-1,4-DihydronicotinamideO-Acetyl-L-SerineAsp Val ValErucamideTetracyclineCascarillinAsp Ile LysGpcho(18:0/20:4)Nicotinic AcidTrp IleTyr Gly3,5-DihydroxyphenylglycineCis,Cis-Muconic AcidDimethyl PhosphateTraversianal1,2-Octanoylphosphatidylcholine1,3-DicyclohexylureaHexadecanamideLpc(18:1)Ile LeuByakangelicolHeteropeucenin, Methyl EtherGluconapinL-GlycineDodecylglycerol1,2-Epoxy-3-(P-Nitrophenoxy)PropaneDodecamethylcyclohexasiloxane14-Hydroperoxy-H4-NeuroprostaneProstaglandin F3ADiethyltoluamideEpinephrine13,14-Dihydro-15-Keto-Pga2Avocadene2-(1-Pentenyl)FuranO-Arachidonoyl GlycidolBergaptenTolueneEthyl 3-HydroxydodecanoateCitronellic AcidSm(D16:1/18:1)6,10-Dimethyl-5(E),9-Undecadien-2-OnePhosphocreatineCapivasertibIsoleucylarginine1,2-DihydronaphthaleneS-LactoylglutathioneValylprolinePhenylacetic AcidDg(20:4(8Z,11Z,14Z,17Z)/18:0/0:0)Dg(16:0/18:1(11Z)/0:0)LubiprostoneTobramycin5-Pentyl-2-Furanoctanoic AcidfalseX-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A AxisKeloid radiotherapy is clinically effective but has an incomplete underlying molecular mechanism and limited accessibility; we used X-ray exposure to identify effector pathways replicating its antifibrotic benefits without further radiation. After collecting patient keloid samples, primary human keloid fibroblasts and normal skin fibroblasts, non-targeted metabolomics and RNA-seq were performed, identifying phytosphingosine (PHS) and KIF20A as key mediators of fibrosis and cell death in keloid radiotherapy. X-ray irradiation increased PHS release in keloid fibroblasts; exogenous PHS and X-ray irradiation independently induced cell death and reduced fibrosis, their combination exerted radiosensitization by boosting G2/M arrest and apoptosis while lowering fibrosis progression, and both PHS and irradiation reduced KIF20A whose loss induced cell cycle arrest and apoptosis. Our findings reveal that X-ray irradiation enhances keloid fibroblast PHS secretion that downregulates KIF20A to exert keloid therapeutic effects, and topical PHS or KIF20A-targeting agents are immediately translatable alternatives for radiotherapy-ineligible patients.2026-06-062026-05-08MTBLS14461HMDB0032848HMDB0254324HMDB0255543HMDB0258057HMDB0257345HMDB0000211;PW_C000137HMDB0000870;PW_C000693HMDB0006899HMDB0034267HMDB0000719HMDB0000161;PW_C000105HMDB0002393HMDB0015673HMDB0028724HMDB0015122HMDB0005821;HMDB0005826;HMDB0005826;PW_C002585HMDB0002757;PW_C001701HMDB0029436HMDB0060509HMDB0000625HMDB0000868HMDB0301830HMDB0028697HMDB0000656HMDB0011738HMDB0257215HMDB0001199HMDB0249989HMDB0028784HMDB0012210HMDB0257254HMDB0000943HMDB0001900HMDB0245001HMDB0029144HMDB0000156;PW_C000101HMDB0000639;LMFA01170107HMDB0011160HMDB0247459HMDB0001068;HMDB0258206;HMDB0258206HMDB0011649HMDB0060176HMDB0000362HMDB0001401;HMDB0246205;PW_C001083HMDB0001316;PW_C001015HMDB0000304HMDB0000542HMDB0247869;PW_C001034HMDB0000288;PW_C000194HMDB0006272HMDB0000849HMDB0001044HMDB0000014HMDB0000812;PW_C000649HMDB0001051;PW_C000828HMDB0029075HMDB0035178HMDB0000175HMDB0012302HMDB0000157;PW_C000102HMDB0000403HMDB0006556HMDB0252615HMDB0028831HMDB0258911HMDB0255986HMDB0011617HMDB0034861HMDB0000292;PW_C000198HMDB0003337;HMDB0011691;HMDB0003337;PW_C001847HMDB0304167HMDB0002035HMDB0002089HMDB0257155HMDB0041208HMDB0001138HMDB0029433HMDB0256965HMDB0255868HMDB0255048HMDB0000634;LMFA01170099HMDB0000958HMDB0012161HMDB0005923HMDB0000172;PW_C000112HMDB0014513HMDB0000766HMDB0028969HMDB0029539HMDB0037848HMDB0032523HMDB0028896HMDB0028823HMDB0000195;HMDB0247301;PW_C000127HMDB0000133;PW_C000087HMDB0028743HMDB0002331HMDB0304487HMDB0245812HMDB0246938HMDB0028804HMDB0252449HMDB0256618HMDB0248312HMDB0000071;PW_C000050HMDB0252788HMDB0000884HMDB0001200HMDB0011167HMDB0258059HMDB0040833HMDB0028691HMDB0000159;PW_C000104HMDB0062590HMDB0000975;PW_C000776HMDB0040482HMDB0004081HMDB0000617HMDB0029064HMDB0029379HMDB0012150HMDB0249634HMDB0034229HMDB0258577HMDB0259276HMDB0242158HMDB0259710HMDB0028876HMDB0028830HMDB0028941HMDB0251757HMDB0030396HMDB0250858HMDB0252807HMDB0000448;LMFA01170048HMDB0247746HMDB0028991HMDB0243515HMDB0258954HMDB0029131HMDB0253794HMDB0036635HMDB0029109HMDB0000755HMDB0028822HMDB0304842HMDB0246429HMDB0253405HMDB0304790HMDB0011170HMDB0252568HMDB0001248;HMDB0252293HMDB0029156HMDB0257474HMDB0029079HMDB0259352HMDB0241246HMDB0303186HMDB0250782HMDB0257476HMDB0000695;PW_C000547HMDB0000244;HMDB0247501;PW_C000165HMDB0244402HMDB0304506HMDB0242014HMDB0247263HMDB0029086HMDB0253280HMDB0029087HMDB0252246HMDB0256072HMDB0033433HMDB0301735HMDB0256230HMDB0256237HMDB0247386HMDB0256170HMDB0242129HMDB0245260HMDB0012642HMDB0039121HMDB0243712HMDB0010357HMDB0002466HMDB0014819HMDB0000193;PW_C000125HMDB0001449;LMST02030130HMDB0254182HMDB0036686HMDB0012517HMDB0032929HMDB0000792;LMFA01170006HMDB0000949HMDB0011562HMDB0001518HMDB0000888;LMFA01170007HMDB0002752;PW_C001699HMDB0254897HMDB0094711HMDB0037326HMDB0303698HMDB0005083HMDB0259248HMDB0246457HMDB0240594;LMFA08020080HMDB0031299HMDB0033071HMDB0002656HMDB0036684HMDB0033601HMDB0015299HMDB0244272HMDB0000394HMDB0302723HMDB0248490HMDB0000806;LMFA01010014;PW_C000643HMDB0007883HMDB0038196HMDB0003876;LMFA03060087HMDB0008944HMDB0060319HMDB0250270HMDB0245577HMDB0010395HMDB0243972HMDB0007988HMDB0112341HMDB0303903HMDB0009012HMDB0010217;LMFA03060011HMDB0249633HMDB0000672;LMFA01170022HMDB0062432HMDB0249467HMDB0248168HMDB0014892HMDB0036621HMDB0002226HMDB0000826;LMFA01010015HMDB0259600HMDB0241658HMDB0000422HMDB0011717HMDB0061657HMDB0302107HMDB0010385HMDB0008835HMDB0008876HMDB0009645HMDB0059915HMDB0011352HMDB0009069HMDB0112391HMDB0038506HMDB0240599HMDB0013825HMDB0112187HMDB0001043;LMFA01030001;PW_C000821HMDB0062336HMDB0009024HMDB0112426HMDB0001551HMDB0036442HMDB0259247HMDB0010568HMDB0002088HMDB0241962;LMFA08020116HMDB0010738HMDB0034153HMDB0008943HMDB0009025HMDB0000564HMDB0240388HMDB0001991HMDB0008834HMDB0062385HMDB0002074HMDB0004973HMDB0304647HMDB0013420HMDB0008975HMDB0008984HMDB0007946HMDB0011391;LMGP02030061HMDB0002068HMDB0061482HMDB0008946HMDB0001087HMDB0000139;PW_C000090HMDB0010708HMDB0012316HMDB0008844HMDB0248147HMDB0061695HMDB0256522HMDB0256523HMDB0011481HMDB0000816HMDB0061704HMDB0240597HMDB0240764HMDB0012411HMDB0240686HMDB0009036HMDB0250272HMDB0270772HMDB0114014HMDB0010564;LMGP02010326;PW_C006572HMDB0009386HMDB0011342HMDB0302828HMDB0009346HMDB0008992HMDB0242099HMDB0242645HMDB0290728HMDB0250916HMDB0002972HMDB0000202;LMFA01170118;PW_C000130HMDB0240680HMDB0002384;LMFA06000098HMDB0013701HMDB0261115HMDB0032549HMDB0031044;LMFA05000641HMDB0285203HMDB0011343HMDB0038070HMDB0062195HMDB0243890HMDB0240598HMDB0252548HMDB0248075HMDB0031513HMDB0010731HMDB0009187HMDB0007861HMDB0062310HMDB0002925;HMDB0247333HMDB0003426HMDB0285202HMDB0261238HMDB0010165HMDB0006528;LMFA04000049HMDB0031060HMDB0005972HMDB0000268HMDB0036054HMDB0006294HMDB0001878HMDB0000208HMDB0002428HMDB0008849HMDB0038720HMDB0011152HMDB0002183;PW_C001472HMDB0011511HMDB0242112HMDB0112382HMDB0035915HMDB0011341HMDB0062305HMDB0241959HMDB0011475HMDB0011473HMDB0001999;PW_C001337HMDB0004670HMDB0005998;LMFA03060009HMDB0029683HMDB0002261;LMFA01050484HMDB0012097HMDB0008020HMDB0041085HMDB0008842HMDB0060580HMDB0032063HMDB0112335HMDB0011517HMDB0259804HMDB0001886HMDB0002059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