MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14509/m_MTBLS14509_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14509/m_MTBLS14509_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14509/s_MTBLS14509.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14509/a_MTBLS14509_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14509/a_MTBLS14509_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14509/i_Investigation.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14509<p>Metabolite annotation was accomplished by comparing precise molecular weight, secondary fragment spectra and characteristic retention time with multiple public databases including HMDB, METLIN, KEGG and self-built plant metabolite library. Qualitative identification was confirmed according to mass error tolerance and fragment ion matching degree, followed by metabolic pathway enrichment analysis.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>Parameter Value[Chromatography Instrument]: Agilent 1290 Infinity Ultra High Performance Liquid ChromatographyParameter Value[Autosampler model]: Agilent 1290 Standard AutosamplerParameter Value[Column model]: Waters ACQUITY UPLC HSS T3 Column (1.8 μm, 2.1 mm × 100 mm)Parameter Value[Guard column]: Waters HSS T3 VanGuard Pre-column (1.8 μm, 2.1 mm × 5 mm)</p>Metabolomic responses of Solanum lycopersicum to Tuta absoluta infestation and TaCRVP effector expression.Fujian Agriculture and Forestry UniversityJianquan Yanleafmass spectrometry assay<p>The frozen tomato leaf samples were ground thoroughly under low temperature. Metabolites were extracted using ice-cold organic extraction solution via vortex mixing and ultrasonic-assisted extraction. After high-speed refrigerated centrifugation, the supernatant was collected, concentrated and redissolved. The resulting solution was centrifuged again and filtered through microporous membrane for subsequent UHPLC-MS/MS detection.</p>Solanum lycopersicumhttps://www.ebi.ac.uk/metabolights/MTBLS14509Youming Hou. Fujian Agriculture and Forestry University. ymhou@fafu.edu.cn.Jianquan Yan. yanjq3018@126.com.<p>Original mass spectrometry raw data were imported into Progenesis QI software for peak matching, retention time alignment, peak identification and data normalization. Unreliable low-quality peaks were eliminated. PCA and OPLS-DA were performed to screen differentially expressed metabolites among experimental groups of tomato leaves.</p>Treatmentyanjq3018@126.com<p>Fresh leaf tissues of Solanum lycopersicum were rapidly collected and cleaned to remove surface impurities. All leaf samples were immediately frozen in liquid nitrogen to terminate metabolic reactions, then preserved at −80 °C in a refrigerator until untargeted metabolomics analysis.</p>MetabolomicsPlant Defense Against HerbivoryMetabolomicsuntargeted analysisSolanum lycopersicumXCMSexperimental blankNovogene Bioinformatics InstituteAgilent 1290 Infinity HPLCleafAB SCIEX TripleTOF 6600Plant Defense Against HerbivoryMetabolomicsuntargeted analysisSolanum lycopersicumXCMSexperimental blankNovogene Bioinformatics InstituteAgilent 1290 Infinity HPLCleafAB SCIEX TripleTOF 6600<p>Parameter Value[Scan m/z range]: 60–1000 m/zParameter Value[Instrument]: AB Sciex TripleTOF 6600 Mass SpectrometerParameter Value[Ion source]: Electrospray Ionization (ESI), positive and negative ion modesParameter Value[Mass analyzer]: Time-of-Flight (TOF)</p>RiboflavinDehydrooreadoneCallicarpenalMethyl haplodesertoateButyl isobutyl phthalateMG(18:2(9Z,12Z)/0:0/0:0)[rac]Nicotinic acid ribosidecis-11,14-Eicosadienoic acidCycloschkuhriadiol acetateN-trans-p-coumaroyloctopamineWoodhousinDL-ThreonineMethyl 15-acetoxy-7-labden-17-oateH-Val-Glu-OH1,5-Naphthalenediamine(Z)-2-octylpent-2-enedioic acidL-ProlineBeta-asaroneLys Leu Asp3-Hydroxy-3-methylglutarateTofacitinibLabienoxime2'-Amino-2'-deoxyadenosine(-)-Sonchuside GNordercitinSafracin ASer Glu Glu(+)-Musacine AProstaglandin E1S-Methyl-methioninesterculynic acidH-Leu-Asn-OHalpha-Methylstyrene(25R)-3beta,4beta-dihydroxycholest-5-en-26-alPA(18:3(6Z,9Z,12Z)/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))4-Methylene-L-glutamine2-Hydroxy-3-phenylpropenoateicosasphinganineAdenine monohydrochloride hemihydrateThr Leu(9Z,12E)-15,16-dihydroxyoctadeca-9,12-dienoic acidMorin6E-Geranylgeraniol-19-oic acid-1-O-methyl etherMethyl 2-acetyltormentate17beta-(Acetylthio)estra-1,3,5(10)-trien-3-ol acetate6-cis-Docosenamide1-MonopalmitinNeurymenolide Bgamma-GlutamylphenylalanineCDP-DG(18:0/20:3(5Z,11Z,14Z)-O(8,9))FarnesolOleamide(1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate3-(2-Hydroxyphenyl)propanoic acidAla-Leu-Leu-AspFugaxinSulpinine A2'-EpiisotriptiliocoumarinFomlactone BVindolineIsopongaflavoneUlipristal acetate(+/-)-Abscisic acid(+)-Isoaminobisabolenol aErucic acidEsprocarbN-PivaloylanilineSM(d19:1/20:5(6E,8Z,11Z,14Z,17Z)-OH(5))Fabianine(+)-CedronelloneAbbeymycinSuccinyladenosine4,5-Dimethoxy-3,3',4'-trihydroxybibenzyl1,3-dihydroxypropan-2-yl (9E,12E,15E)-octadeca-9,12,15-trienoatePhlegmariurine ACanthaxanthin(+)-Sophoranol N-oxidestellatic aldehydeAcrovestoneTyr Gln PheHexadecanedioic acidLysoPE(0:0/20:5(5Z,8Z,11Z,14Z,17Z))Aminobutyl benzamidePlakortolide Kalpha-Cyclogeraniol acetateGln Trp TrpLanyuamide IIIProstaglandin D24-MethoxybenzaldehydeBellendineKetobemidoneDehydrotomatineMono(1-ethylhexyl) phthalateAndrostanediol-17gTehranolidePentamethoxyacetophenoneH-LEU-LEU-ALA-OHMakaluvamine AferuloylagmatineCDP-DG(20:2(11Z,14Z)/18:2(9Z,11E)+=O(13))D-MannosamineVitamin B5Emetamine3-MethyladenineIsocurcumenolIndoleIndole-3-carbinolMG(0:0/18:1(9Z)/0:0)Halaminol CPro Ile Ala4,4'-Diapolycopenedialbeta-IononeOlivetolLitseakolide BCinmethylinObacunone3,7-Dimethyl-2,5-octadiene-1,7-diolLoliolide13-OxoODEAdenosine(1S-cis)-4-[2,2-Dimethyl-3-(4-methyl-3-furanyl)cyclopropyl]-2-butanone(+)-trans-alpha-IroneLagochilinPumiliotoxin 251DTomatidineHalisphingosine A(13S,14S)-epoxymaresinLinoleic acidMagnoshininCPA(16:0/0:0)NEROLL-TyrosineLitsenolide C1Oligomycin AFumagillolChiricanine EHolidinineselenoneineLys Val LeuPA(22:4(7Z,10Z,13Z,16Z)/18:3(9,11,15)-OH(13))(R)-1-Methyl-4-(1-methyl-5-hexenyl)-benzenePeimine19-HydroxyconopharyngineDodecanamideL-PhenylalanineTrinoranastrepteneInosine-5'-carboxylateFarnesyl acetateAgrocybenine2-Oleoyl-sn-glycero-3-phosphocholinePiclamilastIoneneG(8-O-4)S GlycerolSpermidineAntibiotic KO 7888CMG(i-18:0/0:0/0:0)CPA(18:2(9Z,12Z)/0:0)NardosinoneCatuabine GSenkyunolide H2-amino-5-chloromuconic acid 6-semialdehydeQuadrangularic acid GLicarin AProsapogenin AQuercetin 3-(2R-apiosylrutinoside)N-Malonyltryptophan17beta-Amino-5alpha-androstan-11beta-olCer(d18:0/18:0)2-ChlorooctadecanalBrunnein AAspartylphenylalaninePro Pro ArgSclareolideAmbroxide2,7-Dihydroxy-3-isopropyl-2,4,6-cycloheptatrienoneClotrimazolePhenylacetaldehydeSinensol FLysoPE(0:0/16:0)Thymol glucosidePA(20:1(11Z)/22:5(4Z,7Z,10Z,13Z,19Z)-O(16,17))RuspolinoneArtomunoisoxanthone6alpha-Angeloyloxy-4alpha-hydroxy-3,4,13,14-tetrahydrokolavenic acid3-MethoxyanthranilatePalythoalone BGuanineBombykolH-D-Tyr-val-gly-OHOctadecylamine5'-MethylthioadenosineLeukotriene D4 methyl esterDEHPDarlingine2-PalmitoylglycerolSM(d18:0/20:4(5Z,8Z,11Z,14Z)-OH(19S))DileptCyclolinopeptide D2,4,6-Triethyl-1,3,5-trithianeC16 SphinganineLeucylarginineSpirostanDepdecinMicrosporin Btrans-Ferulic acidTecostanine3E,5E-tridecadienoic acid(8S)-8-Amino-7-oxononanoylcarnitinePiscrocin GMethyl alpha-EleostearateStearidonic AcidSorbitan oleateHispaglabridin ABicyclo[4.2.0]octa-1,3,5-trieneCortisol3beta-Fluoro-5beta-pregnan-20-oneH-Val-Leu-OH1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamideNortricycloekasantalic acid25-O-MethylcimigenolBruceine DBrunfelsamidineIlekudinoside JAcanthomine AHeptadecatrienalcis-10-Heptadecenoic acidN-Stearoyl MethionineDihydrotetrodecamycinhomo-Plakotenin8-Azabicyclo[3.2.1]octaneHericenone CArtelastochromeneFurcatoside CAbacavirPA(20:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))TryptopholHomostachydrineL-Lysine3beta,4alpha-Dihydroxy-13beta-methoxylupanineRubipodanone A5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrolN-MethylcorydaldineHexadecasphinganinePhe Glytetradec-5-ynoic acidMontiporyne FOctylamineSphinganineSpathulenolDysinosin DXenimanadin CConsiculine14-DeoxyandrographolideDehydrocarvacrolMetoprololAllanxanthone B4-Hydroxybenzyl alcohol9-Oxo-10,12-octadecadienoic acidN-Methylpelletierine7-Oxo-14-nor-4-isocedren-15-alLysylphenylalanineCamellimidazole FCalcidiol4-Allylpyrocatechol sulfatePS(18:3(6Z,9Z,12Z)/LTE4)KauraneHeptanoylcarnitineoleoyl ethanolamideGamma-Glu-LeuValpromide9,10-EOT4-ISOPROPYLANILINECalicoferol IApo-10'-zeaxanthinalCalicoferol GN,N-DimethylguanosineN'-FormylkynureninePirbuterolDelta(1,7)-dafachronic acid2alpha,3alpha-(Difluoromethylene)-5alpha-androstan-17beta-ol acetateArteglasin ABergeninL-LeucineTrigonellineDG(i-22:0/0:0/LTE4)Posoquenin4-Isopropylbenzyl alcoholVal Thr GlnIriomoteolide 1aStyrenecis-11-Eicosenoic acidDihydroactinospectacinRetinoic acidTuliposide BKalkitoxinBatrachotoxinDicraninPortentolArtemisinin12-OPDA5-oxoprolineCinncassiol CJuvenile hormone II acidFeruloylputrescineGeijeren1-pentadecylglycerone 3-phosphateAzacyclotridecan-2-one(3'Z,5'Z)-CelaxanthinBlonanserinArg Phe ThrHexadecanoylpyrrolidine2-Amino-1-phenylethanolCathafuran AGlycidyl stearateBiotin sulfone10-DeacetoxybarbilycopodinEstranePGP(18:0/16:1(9Z))Gitogenin(6R,9S)-3-Oxo-alpha-ionol beta-D-glucoside4,8 dimethylnonanoyl carnitineL-ValineAndrachcinidine7-O-Demethyl-18-hydroxy-albocyclineSer Ile PheNicotianamineGeinHippuristerone KLysoPC(18:3(6Z,9Z,12Z)/0:0)Indolelactic acidArg-Pro-Pro-Gly-Phe-Ser-Pro5-Hydroxy-8-methoxycalamenenePentadecanolidePhytosphingosine3-Deoxyestradiol16-Heptadecyne-1,2,4-triolCytosineIndoleacrylic acidD-Fructofuranose 1,2':2,3'-dianhydrideClopenthixol decanoateTrp Glu IleKermadecin HDichotomine BNitramineBisphenol A bis(2-hydroxyethyl)ether11beta-HydroxyandrosteroneFumigatoninMethyl 3,4-dihydronidorellaurinateCorymbi-7,13E-dienolideLauramine oxideParadolBroussonetinine BCalealactone BLysoPC(18:2(9Z,12Z)/0:0)(3R)-3,21-dihydroxyhenicosanoic acidPelletierineL-Argininegamma-Linolenic acidFicusin B5-Hydroxyisourate7alpha,12alpha-Dihydroxy-3-oxochol-4-enoateTumonoic Acid Balpha-Linolenic acid(-)-10-Methoxyvincamedine N-oxidePhenylethylamineHis Ala Gln3-(4-Methyl-3-pentenyl)thiopheneTerminalineTriptolideN-Hexanoyl-L-homoserine lactoneN6,N6,N6-Trimethyl-L-lysineSubamolide CHongdoushan ASpirasine IXMycaleoximeAjubractin D4-Heptyloxybenzoic acidCapsi-amideN6-ThreonylcarbamoyladenosineH-Ile-Gln-OH[R-(E)]-4-(4-Methyl-3-cyclohexen-1-yl)-3-penten-2-oneStrobilol CDimethylglycineVinylamycinVal Ile LeuPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/15:0)PA(18:3(9Z,12Z,15Z)/0:0)4,4-Difluoropregn-5-ene-3,20-dioneAla Val Phe2alpha,9beta-Dihydroxy-3beta,8beta-oxido-1(15)-trinerviteneLysoPE(18:2w6/0:0)Diprotin APalmitoylglycinePanthenolbeta-Damascone(Z)-5,8,11-trihydroxyoctadec-9-enoic acidTerezine BCarbazoquinocin EPicrinine9-HodeStearamidePA(20:1(11Z)/22:6(5Z,8E,10Z,13Z,15E,19Z)-2OH(7S, 17S))Arg Val LeuSM(d17:1/22:6(4Z,7Z,10Z,12E,16Z,19Z)-OH(14))Myristamine OxideEctocarpen(+/-)-2-Phenyl-4-methyl-2-hexenalSedanolideL-MethioninePergolideMOPEDendronobiloside BPIP(18:1(15Z)/6 keto-PGF1alpha)QuercimeritrinNicotinamideN-(9-oxodecyl)acetamide2-amino-1,3,4,5-icosanetetrolMethyl dihydrojasmonateSer Asp Arg(-)-StephabinamineMethyl phenylacetate1-Dehydro-9-fluoro-11-oxotestololactoneObscuraminol ASer LeuHymenoside TIgernellinH-D-Trp-OH1-MonomyristinShogasulfonic acid AGlucovanillinCallyspongenol Ao-CymolLacinilene DPicolinic acidMG(0:0/18:2(9Z,12Z)/0:0)Tashironin1-Dodecyl-2-pyrrolidinonesn-Glycero-3-phosphocholineaxinastatin 3PyridoxatinPalmitoleoyl Ethanolamide(-)-Asbestinine 2Benzo[a]pyrene-cis-4,5-dihydrodiol1,8-Bis(4-hydroxybenzyl)-2,7-dihydroxy-4-methoxyphenanthreneAnnosquamosin G1-(9Z,12Z-octadecadienoyl)-glycero-3-phosphateEpoxymicheliolide1,4-DiphenethylpiperazineN-trans-Feruloyltyramine3-Ethyltoluene(-)-Ceriferol 1(-)-EpigallocatechinL-GlutaminegabapentinC25-Epoxy-apo-aldehydeDolichol phosphate6alpha-Hydroxy-castasteroneLys Pro HisSalinosporamide DIxerochinolideRuprechstyrilHormodireneSphingosine (d17:1)Jolkinol B20-hydroxy-fusarinDifluprednateSer Leu IleDipfluzineEserolineMethyl (10E,12Z,15Z)-9-hydroxyoctadeca-10,12,15-trienoateLinoleic acid amide(9Z,12Z,15Z)-(7S,8S)-Dihydroxyoctadeca-9,12,15-trienoic acidPinoresinol dimethyl etherMG(0:0/18:0/0:0)Hysterone D4-Methoxyphenethyl alcohol(+)-CodonopsineAsymmetric dimethylarginineIncensole Acetate(5S)-6-Hydroxy-5-isopropenyl-2-methylhexanoateVal Ile Asp6-OxocineoleChokol GcolistinDG(PGF2alpha/0:0/2:0)InositolpimobendanN-formylanthranilic acidPhosphorylcholine4-Epiphyllanthine3-MethylindoleGlycyl-L-leucineIle Pro Val24-methylene-19-norcholesta-1,3,5(10)-trien-3-olAbafunginPlatenolide B mycaroseHistamineLys Ile LeuPhaseoloidinSolasodinePetroselaidic acid(C18-1T)Dibutyl maleateDiosgeninBisabolol oxide A3-hydroxylauroylcarnitineDyclonineLibanotic acidspinosyn macrolactone2-linoleoyllysophosphatidylcholine2,2,6,7-Tetramethylbicyclo[4.3.0]nona-1(9),4-dien(2E)-2,6-Dimethyl-2,5-heptadienoic acidPA(20:5(5Z,8Z,11Z,14Z,17Z)/22:6(4Z,7Z,10Z,12E,16Z,19Z)-OH(14))(7S,8S)-DiHODESarcrassin CNordihydrocapsaicinPro IleTuberatolide AN-CyclohexylformamideCaulophyllumine Ap-CresolDihydrocodeineL-isoleucyl-L-prolineO-Acetyl-L-homoserineMycalamide APellitorineTrp Asp TyrAspochalasin HDauricosideLunularic acidHis-Pro2'(R)-HydroxylanneaquinolLeu-Val-GlyGln Leu LeuCoumanolignanNefopamPA(20:1(11Z)/22:5(4Z,7Z,10Z,13Z,16Z))Tetradecyl iodideValylprolineMarrulanic acid7,8-Didehydro-beta-micropteroxanthinPA(22:5(4Z,7Z,10Z,13Z,16Z)/22:5(4Z,7Z,10Z,13Z,16Z))Vibrio Cholerae O1, serotype Ogawa disaccharidefalseMetabolomic responses of Solanum lycopersicum to Tuta absoluta infestation and TaCRVP effector expressionThis study presents the metabolomic profiling of Solanum lycopersicum in response to feeding by the herbivorous insect Tuta absoluta and the overexpression of its salivary effector, TaCRVP. To elucidate how this effector manipulates host immunity at the metabolic level, we performed untargeted LC-MS analysis.The study aimed to investigate the metabolic reprogramming induced by the insect salivary effector TaCRVP. The metabolomic results demonstrate a significant downregulation of precursor pathways for jasmonate (JA) synthesis in TaCRVP-OE lines. These metabolic signatures strongly indicate that the TaCRVP effector actively subverts plant oxidative defenses and effectively dismantles the downstream JA-mediated defense network to facilitate insect adaptation.2026-05-182026-05-18MTBLS14509Com_471_negCom_517_negCom_378_negCom_482_negCom_257_negCom_542_negCom_462_negCom_313_negCom_99_negCom_174_negCom_299_negCom_403_negCom_390_negCom_430_negCom_300_negCom_432_negCom_493_negCom_229_negCom_466_negCom_31_negCom_90_negCom_458_negCom_298_negCom_500_negCom_144_negCom_492_negCom_438_negCom_311_negCom_506_negCom_486_negCom_400_negCom_1_negCom_69_negCom_213_negCom_231_negCom_417_negCom_45_negCom_371_negCom_36_negCom_11_negCom_233_negCom_176_negCom_412_negCom_193_negCom_44_negCom_285_negCom_297_negCom_308_negCom_249_negCom_534_negCom_419_negCom_81_negCom_153_negCom_499_negCom_194_negCom_456_negCom_17_negCom_443_negCom_281_negCom_336_negCom_185_negCom_166_negCom_541_negCom_386_negCom_207_negCom_210_negCom_49_negCom_7_negCom_86_negCom_30_negCom_42_negCom_83_negCom_57_negCom_164_negCom_52_negCom_137_negCom_178_negCom_80_negCom_115_negCom_159_negCom_51_negCom_244_negCom_46_negCom_179_negCom_296_negCom_414_negCom_171_negCom_59_negCom_276_negCom_435_negCom_156_negCom_8_negCom_408_negCom_82_negCom_50_negCom_39_negCom_120_negCom_3_negCom_148_negCom_245_negCom_27_negCom_47_negCom_24_negCom_28_negCom_117_negCom_101_negCom_340_negCom_488_negCom_225_negCom_121_negCom_269_negCom_65_negCom_342_negCom_192_negCom_9_negCom_265_negCom_74_negCom_450_negCom_142_negCom_10_negCom_23_negCom_208_negCom_343_negCom_601_negCom_1100_negCom_1562_negCom_1898_negCom_1671_negCom_2460_negCom_2528_negCom_633_negCom_2067_negCom_1015_negCom_962_negCom_815_negCom_1495_negCom_991_negCom_1718_negCom_2655_negCom_2663_negCom_1344_negCom_1684_negCom_1533_negCom_1716_negCom_605_negCom_1766_negCom_1161_negCom_2521_negCom_1201_negCom_2198_negCom_1125_negCom_886_negCom_759_negCom_766_negCom_1603_negCom_1247_negCom_853_negCom_1873_negCom_1997_negCom_1057_negCom_931_negCom_977_negCom_1649_negCom_2122_negCom_1546_negCom_2534_negCom_1435_negCom_982_negCom_2111_negCom_1314_negCom_1309_negCom_2446_negCom_1763_negCom_1493_negCom_1007_negCom_2001_negCom_1350_negCom_1781_negCom_628_negCom_1701_negCom_2243_negCom_2707_negCom_1287_negCom_1769_negCom_1160_negCom_1412_negCom_553_negCom_2504_negCom_1864_negCom_1799_negCom_644_negCom_707_negCom_1524_negCom_802_negCom_1633_negCom_1200_negCom_1662_negCom_868_negCom_2606_negCom_2626_negCom_2612_negCom_2559_negCom_1172_negCom_679_negCom_1776_negCom_1661_negCom_1028_negCom_890_negCom_971_negCom_1312_negCom_1218_negCom_1377_negCom_685_negCom_708_negCom_1062_negCom_743_negCom_1373_negCom_2622_negCom_2631_negCom_2601_negCom_2584_negCom_2487_negCom_2445_negCom_2417_negCom_2323_negCom_2153_negCom_2145_negCom_2105_negCom_2086_negCom_2082_negCom_2003_negCom_1931_negCom_1870_negCom_1859_negCom_1808_negCom_1795_negCom_1783_negCom_1702_negCom_1652_negCom_1534_negCom_1517_negCom_1451_negCom_1331_negCom_1178_negCom_968_negCom_837_negCom_808_negCom_619_negCom_602_negCom_609_negCom_586_negCom_570_negCom_547_negCom_2564_negCom_2552_negCom_2539_negCom_2527_negCom_2491_negCom_2293_negCom_2278_negCom_2247_negCom_2233_negCom_2076_negCom_2038_negCom_2028_negCom_1952_negCom_1940_negCom_1928_negCom_1851_negCom_1824_negCom_1813_negCom_1810_negCom_1775_negCom_1683_negCom_1635_negCom_1634_negCom_1584_negCom_1555_negCom_1516_negCom_1499_negCom_1504_negCom_1393_negCom_1351_negCom_1277_negCom_1250_negCom_1185_negCom_1189_negCom_1113_negCom_1145_negCom_1101_negCom_1023_negCom_954_negCom_959_negCom_950_negCom_881_negCom_888_negCom_863_negCom_852_negCom_856_negCom_749_negCom_668_negCom_676_negCom_2569_negCom_2470_negCom_2386_negCom_2250_negCom_2203_negCom_2156_negCom_2152_negCom_2124_negCom_1976_negCom_1933_negCom_1823_negCom_1773_negCom_1753_negCom_1737_negCom_1648_negCom_1640_negCom_1624_negCom_1602_negCom_1508_negCom_1410_negCom_1295_negCom_1274_negCom_1138_negCom_1119_negCom_1039_negCom_1010_negCom_748_negCom_713_negCom_655_negCom_627_negCom_613_negCom_600_negCom_555_negCom_550_negCom_552_negCom_648_negCom_652_negCom_738_negCom_818_negCom_844_negCom_859_negCom_932_negCom_965_negCom_1056_negCom_1108_negCom_1134_negCom_1197_negCom_1230_negCom_1258_negCom_1281_negCom_1293_negCom_1370_negCom_1387_negCom_1419_negCom_1437_negCom_1587_negCom_1621_negCom_1694_negCom_1727_negCom_1822_negCom_1880_negCom_1879_negCom_2035_negCom_2102_negCom_2139_negCom_2161_negCom_2179_negCom_2220_negCom_2257_negCom_2307_negCom_2381_negCom_2382_negCom_2490_negCom_2525_negCom_2548_negCom_2560_negCom_2725_negCom_2694_negCom_2517_negCom_2459_negCom_2252_negCom_2068_negCom_1941_negCom_1048_negCom_786_negCom_839_negCom_877_negCom_1157_negCom_1315_negCom_1561_negCom_1759_negCom_1948_negCom_2304_negCom_2427_negCom_2433_negCom_2628_negCom_2568_negCom_2473_negCom_2169_negCom_2104_negCom_1714_negCom_1143_negCom_742_negCom_544_negCom_2541_negCom_2540_negCom_2456_negCom_2451_negCom_2449_negCom_2408_negCom_2405_negCom_2335_negCom_2236_negCom_2056_negCom_2019_negCom_1854_negCom_1761_negCom_1611_negCom_1604_negCom_926_negCom_757_negCom_1856_negCom_1707_negCom_1542_negCom_1522_negCom_1354_negCom_1292_negCom_695_negCom_584_negCom_557_negCom_2508_neg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