MetaboLights

application/xml

ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14575/m_MTBLS14575_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14575/m_MTBLS14575_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14575/s_MTBLS14575.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14575/a_MTBLS14575_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14575/a_MTBLS14575_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14575/i_Investigation.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14575Based on the ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry, non-targeted metabolomics was conducted. Combined with the metabolomics data processing software Progenesis QI v2.3, qualitative and relative quantitative analyses were performed on the raw data, and the raw data was also subjected to standardized preprocessing. MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseChromatographic column: ACQUITY UPLC HSS T3 (100 mm×2.1 mm, 1.8 um); Column temperature: 45℃ Mobile phase: A- water (containing 0.1% formic acid), B- acetonitrile; Flow rate: 0.35 mL/min; Injection volume: 5 μL.Dendrobium officinale Polysaccharide Ameliorates High-Fat Diet-Induced Hepatic Lipid Metabolic Disorder via the SIRT6/PGC-1α Signaling Axis.noxin denglivermass spectrometry assayWeigh 30 mg of the sample into a 1.5 mL EP tube, add two small steel balls, and add 400 μL of memethanol - water (V:V=4:1, containing L-2-chlorophenylalanine, 4 μg/mL); 2. After pre-cooling in a -40℃ refrigerator for 2 minutes, place it in a grinding machine for grinding (60 Hz, 2 minutes); 3. Ultrasonic extraction in an ice water bath for 10 minutes, and standing at -40℃ for 30 minutes; Centrifuge for 10 minutes (13,000 rpm, 4 ° C), take 300 μL of the supernatant and place it in an LC-MS injection vial to dry. 5. Redissolve with 300 μL of methanol-water (V:V=1:4), vortex for 30 seconds, and ultrasonicate in an ice water bath for 3 minutes; 6. Stand at -40℃ for 2 hours; Centrifuge for 10 minutes (13,000 rpm, 4 ° C), draw 150 μL of the supernatant with a syringe, filter it through a 0.22 μm organic phase pinhole filter, transfer it to an LC injection vial, and store it at -80 ° C until LC-MS analysis is performed. 8. Quality control samples (QC) are prepared by mixing the extracts of all samples in equal volumes.Rattus norvegicushttps://www.ebi.ac.uk/metabolights/MTBLS14575Xin Deng. 2781312168@qq.com.Binhong Hu. Chongqing University of Chinese Medicine. binhong.hu@imbim.uu.se.Based on the ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry, non-targeted metabolomics was conducted. Combined with the metabolomics data processing software Progenesis QI v2.3, qualitative and relative quantitative analyses were performed on the raw data, and the raw data was also subjected to standardized preprocessing. Dendrobium officinale polysaccharideHigh fat diet2781312168@qq.comLiver tissues from male Sprague-Dawley rats were collected postmortem and stored at –80°C until experimental use.MetabolomicsMetabolomicsWaters ACQUITY UPLC I-Class PLUS SystempolysaccharideThermo Scientific Q Exactiveliveruntargeted analysisDiet, High-Fatlipid metabolic processRattus norvegicuspooled sampleHigh fat dietexperimental sampleMetabolomicsWaters ACQUITY UPLC I-Class PLUS SystempolysaccharideThermo Scientific Q Exactiveliveruntargeted analysisDiet, High-Fatlipid metabolic processRattus norvegicuspooled sampleHigh fat dietexperimental sampleBoth positive and negative ionization modes were used.m/z range: 100–1200Resolution (full scan): 70,000 FWHM at m/z 200Resolution (HCD MS/MS): 17,500 FWHMSpray voltage: +3800 VSheath gas flow rate: 35 arbAux gas flow rate: 8 arbCapillary temperature: 320 °C(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaEdtmp9,10-DHOME4-Hydroxynonenal2-Methylpropanal4-(4-Methylphenyl)-2-butanoneGlycidylDacarbazine1,9-Heptadecadiene-4,6-diyne-3,8-diol, (3S,8S,9Z)-4-Hydroxyphenylacetic acid sulfate2-[(Tetrahydrofurfuryl)oxy]ethanolNolatrexedMethyl nicotinateAlpha-TetrasaccharideNiazirin(4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinateKetoleucineLysoPC(0:0/18:2(9Z,12Z))9-Hydroxy-7-megastigmen-3-one glucosideAuxin aAypgkfNitroimidazo-oxazineGabazineProstaglandin H3Acetamide, 2-(diethylamino)-N-(2-(octyloxy)phenyl)-10-HDoHEProstaglandin H2SCHRADANPentaerythritol tetranitrateSulfamoxolePetunidinCitrulline2,5-Dihydroxybenzenesulfonic AcidRO49290972,3-Dimethyl-2-cyclohexen-1-oneIodopindololAlloxan5-MethylnonanoylcarnitineFlavin mononucleotideS-Nitrosohomocysteine3-ethylphenyl SulfateCnidilide2,9-Bis(3-methyl-2E-pentenoyl)-2b,9a-dihydroxy-4Z,10(14)-oplopadien-3-onecis-p-Coumaric acid16, 17-dihydro-16alpha, 17-dihydroxy GA9Guanosine 2'-monophosphateChitotriosePE(20:4(5Z,8Z,11Z,14Z)-OH(20)/18:1(9Z))DimethylcurcuminNorecasantalic acid2-(2-Aminopropanoylamino)bicyclo[3.1.0]hexane-2,6-dicarboxylic acidGalanal AGlucuronic acid sulfate(S)-(+)-1-(p-Hydroxy-trans-cinnamoyl)-glycerolKinetensin 4-7Acetamide, N-[4-[(2-pyridinylamino)sulfonyl]phenyl]-N-Acetylcysteamine5-(3-Methyl-1-triazeno)imidazole-4-carboxamideAgnusideImidazole citrate(+/-)-cis- and trans-2-Methyl-2-(4-methyl-3-pentenyl)cyclopropanecarbaldehydeAlectinibPGP(22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)/i-17:0)4-(Dimethylamino)benzaldehydeSodium alum15d PGD2PregnanediolStreptomycin4-(Trifluoromethyl)benzoic acidDG(22:5(4Z,7Z,10Z,13Z,19Z)-O(16,17)/0:0/i-13:0)6-SulfanilamidoindazoleDihydrocitronellal(S)-7-(3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid8-iso-PGA1gamma-Glutamylphenylalanine3-Oxoadipic acid4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanoneLysoPE(0:0/18:2(9Z,12Z))Cajanin3-(3,4-Dihydroxyphenyl)-1-propanol 3'-glucosideLysoPE(0:0/18:4(6Z,9Z,12Z,15Z))4-Acetamidobenzoic acid2-(1-Ethoxyethoxy)propanoic acidL-Glyceric acidFluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl etherp-Coumaroyl glycolic acid5-DiazouracilPantothenic acid2-Naphthyl dihydrogen phosphate2-Propylglutaric acid2,3,5,6-Tetrafluorobenzenethiol6H-Oxazaphosphinine2,5-Dihydroxybisabola-3,10-diene2-Amino-3-methyl-1-pyrrolidin-1-YL-butan-1-one1,2-O-Isopropylidene-D-glucofuranose4-Methoxyphenylacetic acidPA(22:2(13Z,16Z)/16:0)N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)ureaTetrahydro-2,5-dimethyl-2H-pyranmethanolPteleineTyrosyl-Aspartate10-EdAMPA(a-25:0/20:4(5Z,8Z,10E,14Z)-OH(12S))GlycerophosphoglycerolMetixeneBenzocaineDiphenyl phosphate3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-(1H-imidazol-1-ylmethyl)-6-methyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl esterNeosaxitoxin24(28)-Dehydromakisterone2-Ethyl-1,3,3-trimethyl-2-norbornanolD-Malic acid p-coumarate1H,1'H-2,2'-Disulfanediyl-bis-imidazole2,3-Butanediol glucoside(2xi,3xi)-2,3-Dihydroxy-12,18-ursadien-28-oic acid diacetate2-IodomelatoninEthylene glycol dinitrate2-(p-Acetamidophenyl)-2-ethylglutarimide21-HydroxypregnenoloneGlycylvalinePhthalic acidTipepidineOlpadronic acidProstaglandin D11,2-dibutyrinProstaglandin D32,5-Dimethyl-3-propylpyrazineMahaleboside3-Amino-5-(3-thiophenyl)-2-thiophenecarboxamideLithocholic acid glycine conjugate3-Butyn-1-alMALONONITRILE(E)-7-[(1S,5E)-5-(3-Hydroxyoctylidene)-4-oxocyclopent-2-en-1-yl]hept-5-enoic acidHydroxypropionic acidChenodeoxycholic acidOrnithinecefetametDimethylarsinic acid6-[Ethoxy(mercapto)methylidene]-1-cyclohexa-2,4-dienonekaempferol 3-O-beta-D-glucosyl-(1->2)-glucoside3a,7a-Dihydroxycholanoic acid(2E,4E)-Hexa-2,4-dienedioylcarnitine(5R,6S)-5,6-Epoxy-7-megastigmen-9-oneErythrityl TetranitratePhosphovanillin(2R,3R)-pinobanksinbeta-IonolTert-ButylbicyclophosphorothionateBenzenesulfonyl fluoride(3R,5S,8S,9S,10S,11S,13S,14S)-3,11-Dihydroxy-10,13-dimethyltetradecahydro-1H-cyclopenta[a]phenanthren-17(2H)-oneGlucosyl (E)-2,6-Dimethyl-2,5-heptadienoateDroxicam2-Ethyl-p-xylene2-Nonenal, 4-hydroxy-, (2E,4R)-LysoPE(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)2-AminoethanesulfonamideTyr-GlyBile acidDisodium hydrogen citrate7-Aminobenzo[d]isothiazol-3(2H)-one 1,1-dioxideSialorphin17-phenyl-18,19,20-trinor-prostaglandin E2Thiophene, 2-nitroso-Rimeporide2,6,6-Trimethyl-2-cyclohexene-1,4-dione4-Fluorobenzoic acid3,7-Dihydroxycholan-24-oic acidUralenneosideGabexate8,20-DiHETE2,4-Hexadien-1-olN-Palmitoyl tyrosine12-DehydroporsonChrycolideent-16b,19-Kauranediol 19-acetate1,3,5-Trinitrocyclohexa-1,3-diene(R)-2-Hydroxycaprylic acid20-hydroxyleukotriene B42-hydroxymethylolanzapineAminoethylcysteine ketiminemethyl 1-methylpiperidine-3-carboxylate3-Hydroxytetradecanedioic acid1-(3-Methylbenzoyl)-1H-indazole-3-carbonitrile5-Phenylvaleric acid5'-N-Ethylcarboxamidoadenosine(¡À)-(E)-3-Methyl-4-decen-1-olPerfluoro-15-crown-53-Hydroxybutyric acidN-(2-Methylacryloyl)-L-histidineL-PhenylalaninedCDP5-(Hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-YL)pentanal4'-Hydroxy Nimesulidegamma-Aminobutyryllysine7-(1-Imidazolyl)heptanoic acidhydroxypropyl2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid3,4-Dihydroxybenzeneacetic acid10,11-EpidioxycalameneTraumatic acidTetradecanedioic acidHydantoin-5-propionic acidMethyl 16-hydroxyhexadecanoateSedoheptulose 1,7-bisphosphate7',8'-Dihydro-8'-hydroxyreticulataxanthinEnkephalin L1-(2-Pyridylazo)-2-naphtholD-Gluconamide1-Pyrrolidinecarboxaldehyde, 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-gamma-GlutamylleucineBotryodiplodin12-MethyltridecanalPivmecillinam(¡À)-2-Hydroxy-4-(methylthio)butanoic acidTerephthalic acid9-Hydroxynon-2-enalDocosadienoate (22:2n6)Glucocorticoid receptor agonistMycobactins4-Dodecan-6-ylbenzenesulfonic AcidPA(15:0/LTE4)Valeric acid8-Nitro-cGMPL-CystathionineCrithmumdiolMadam3-Hydroxypropanal6-[5-(4-carboxy-2-hydroxybutyl)-2-hydroxyphenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acidN-Carbamoyl-2-amino-2-(4-hydroxyphenyl)acetic acidBeta-Citryl-L-glutamic acid(9E,12Z)-10-Nitrooctadeca-9,12-dienoylcarnitineVicineCalcium fumarate4-HydroxyvoriconazoleDiphenyl sulfidePS(20:4(5Z,8Z,11Z,14Z)/PGJ2)1-Benzyloxy-1-(2-methoxyethoxy)ethane2,3-Dihydro-6-methoxy-2,2-dimethyl-4H-1-benzopyran-4-one5-HydroxysebacateCalcium propionateLysoPC(0:0/18:1(9Z))7-Nonene-3,5-diyn-1-olalpha-Cyperol4-Methylumbelliferyl phosphate5-Phenyl-1,3-pentadiyneDihydro-3(2H)-thiophenoneXanthosineN-AcetylarylamineMetabolite M6Citric acidMethyl 1-(2-propenylsulfinyl)propyl disulfideAdenosine 2'-phosphate2-Nitrophenyl octyl etherTyrphostin A25gamma-Glutamyl-2-aminobutyrateCyclopropanecarboxamide, 1,2,2,3,3-pentamethyl-DL-PropargylglycinePhthalamic acidN-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine2-(2-Methylbutanoyl)-9-(3-methyl-2E-pentenoyl)-2b,9a-dihydroxy-4Z,10(14)-oplopadien-3-oneFoliandrin5,8,12-Trihydroxy-9-octadecenoic acid8-iso-15-keto-PGE2Nicotine imineTaurolidine13-(3-Pentyloxiran-2-yl)trideca-2,4,6-trienoic acidDaidzein 4'-sulfatePGP(20:3(5Z,8Z,11Z)/20:4(5Z,8Z,11Z,14Z)-OH(17))ProcarbazineQuinestrol(S)-11,12,13-Trinor-7-calamenonePiperonyl isobutyrateEthylene glycol diglycidyl ether(E)-3-Heptenyl acetate5-Hydroxymethyl-2'-deoxyuridineTauroursodeoxycholic acidLysoPA(20:2(11Z,14Z)/0:0)(¡À)-2-MethylhexanalGlycocholic acid2-O-p-Coumaroylhydroxycitric acidN-Myristoyl Proline4-(2-Aminoethyl)benzenesulfonyl fluoride1,2-Dinitrobenzene(E)-7-[4-Hydroxy-2-[(E)-3-hydroxyoct-1-enyl]-6-oxooxan-3-yl]hept-5-enoic acidProlyl-SerineGanciclovir4-Amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamideEthyl phenylglycidate20alpha-DihydroprogesteroneGlucose 6-phosphateSonchuside CAcrimarine JVignatic acid A1,4-IpomeadiolOrotidinePyrrolifenePrenylcysteineMenthone 1,3-glyceryl ketalDesmethylcyproheptadineAranidipine(-)-Epigallocatechin 3-(4-methyl-gallate)PIP(20:0/18:1(12Z)-2OH(9,10))1-deoxy-L-glycero-tetrulose 4-phosphate6-DeoxypenciclovirIsomorellic acidN-Undecylbenzenesulfonic acidLysoPC(17:0/0:0)10-(Phosphonooxy)decyl methacrylateDyphylline2-Methyl-4-heptanoneProline glutamateDibutyl malateDukunolide B4-Methylumbelliferone sulfate1,1,1,2,3,3,3-Heptafluoropropane(¡À)-MetalaxylN-Palmitoyltaurine(2S)-3,4-Dioxoazetidine-2-carboxylic acidtrans-zeatin ribosideBEFLOXATONEPyridylacetylglycineIguratimod2,3,4-TrinitrotolueneLinifanibN-StearoyltaurineL-alpha-amino-epsilon-keto-pimelate12-Oxo-2,3-dinor-10,15-phytodienoic acidChenodeoxycholic acid glycine conjugateProstaglandin I31,2,3,4-Tetrahydro-beta-carbolineHaloperidol4-Hydroxy-3-methoxy-cinnamoylglycineGlucose pyruvate acetatePerfluorooctane sulfonamidoacetic acidAntibiotic CC 10651-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-1,6-heptadien-3-oneN-(Dimethylamino)methylene-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanineArginyl-glycyl-aspartyl-valineColforsin daropateMeproscillarin3-Phenylpropyl formate1,2,2-Trimethylpropyl dimethylphosphinateKuguacin EPhenol glucuronideN-Acetylkynurenine3-Methyl-2-cyclohexen-1-oneD,L-Buthionine2-(2,4-Dimethylphenyl)indan-1,3-dioneZierinDimethylphosphatePalonosetron6-Methoxy-3-(2-thiazolyl)-1H-indole(1R)-trans-PhenothrinCyclohexanecarboxamideFluroxene3,5,5-Trimethyl-2-cyclopenten-1-oneN-Acetyl-7-O-acetylneuraminic acidTaurine3-(5-Acetamido-2-hydroxyphenyl)sulfanyl-2-oxopropanoic acidFurfuryl acetatePhaseolic acidp-Cresol sulfateArachidic acid2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate1,3,7,12-Tetrahydroxycholan-24-oic acidO-PhosphoethanolamineBenzenesulfonic acid20-dihydroxyleukotriene B48-MethyldihydrochelerythrineFluticasone propionatePirbuterolTrifluoroacetic acidLysoPE(18:3(9Z,12Z,15Z)/0:0)1-Fluoro-2,3-dinitrobenzeneSulfinpyrazone sulfideMethaniazideAcorafloxacinDocosatrienoic acid4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide2-Hydroxyterephthalic acidGravolenic acidBenzodioxaphosphorinGarcinia acidInosine triphosphate(2E,11Z)-5-[5-(Methylthio)-4-penten-2-ynyl]-2-furanacroleinNorsanguinarinePyrrole-2,3,5-tricarboxylic acidLeucyl-ValineBezafibrateRibonic acid(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid9-MethylxanthineAzepexoleLysyl-LysinePI(18:3(9,11,15)-OH(13)/20:0)2-Naphthalenesulfonic acidBismuth Subsalicylate16-Hydroxy-10-oxohexadecanoic acidNicotinate adenine dinucleotide phosphateVitamin C phosphateEicosatetraenoic acid, 15-hydroxy-VAS28704,8-Methano-8aH-bisbenzofuro[3,2-e:2',3'-g]isoquinoline-1,8a-diol,7-(cyclopropylmethyl)-5,6,7,8,9,14b-hexahydro-, (4bS,8R,8aS,14bR)-4-Vinylphenol sulfateAlternariolLysoPC(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)Leukotriene C5Quinaldic acid1-HeptadecanoylglycerophosphoethanolamineIbandronate3-Phenylpropionic acid sulfatealpha-Bisabolol oxide C4-Hydroxy-5-methyl-3(2H)-thiophenoneCarbocyclic thromboxane A22-Keto-glutaramic acidPhosphocreatine lactateLysoPE(0:0/22:5(7Z,10Z,13Z,16Z,19Z))Calcein6,7-Dihydro-4-(hydroxymethyl)-2-(p-hydroxyphenethyl)-7-methyl-5H-2-pyrindiniumurea citrateSAPERCONAZOLEBoc-phepsi(CH(OH)CH2)phe-val-phe-morpholine(+)-7-iso-jasmonateCyclopropyl-methoxycarbonyl metomidateLysoPE(0:0/22:2(13Z,16Z))3-Benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethylamino)hydantoinManganese citrate4-hydroxybenzoic acid-4-O-sulphateFurazolidoneEicosadienoic acidProtosappanin AThreonylaspartic acidPhenol sulphateAc-Thr-D-Trp(CHO)-Phe-NMeBzl2-Hydroxyhexadecanoic acidMyosmine(R)-2-Amino-3-(2-propynylthio)propanoic AcidAcetylhomoserineMethyl 3,5-dinitrobenzoatePseudoecgonineNopalinic acidDifloxacinDiflunisalSolerolPentafluoropropionic acid2-((2-(Dimethylamino)ethyl)thio)-3-phenylquinoline1,3-DinitroglycerinCaprylic acidTRIMETHYL PHOSPHATEShikimic acid 3-phosphateIDPUmbellipreninCholesterol sulfateSuvorexantDihydrojasmonic acidButylone6-(1,2,3,4-Tetrahydroxybutyl)oxane-2,3,4,5-tetrolPhenylalanyl-AlaninePantetheine 4'-phosphateVal-Gly-Val-Ala-Pro-GlyN-(4-Amino-2,5-diethoxyphenyl)benzamideA,b-Dihydroxyisobutyric acidSimazine2,6-Diaminopurine 2',3'-dideoxyribosideAlamifovir6-C-beta-D-Glucopyranosyl-5,7,2',4',5'-pentahydroxyflavone7-O-Acetylaustroinulin17-AAG2-Phenyl-1,3,5-triazineAdipic acid2-O-Methyl-D-xylose3-hydroxybenzoic acid-3-O-sulphateIsotrichoderminTheaflavic acidPE-NMe2(16:1(9Z)/20:5(5Z,8Z,11Z,14Z,17Z))3-AcetylthiopheneEthofumesate2-Methylpropyl formateIreneDaptaTaurochenodesoxycholic acid3-((Dimethylamino)methyl)-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one3-(3,5-Diiodo-4-hydroxyphenyl)lactateCDP-glucoseMono-(3-carboxypropyl) phthalateOxyhumulinic acidHomovanillic acidD-ribulose-1,5-bisphosphate2-Methylthiazolidine-4-carboxylic acid2-Phosphonopropionic acidN-(2-Hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl)acetamideQuinolinic acid3-(2-Furoyl)quinoline-2-carboxaldehyde20-oxo-leukotriene B4(11S,12S,13S)-Epoxy-hydroxyoctadeca-cis-9-cis-15-dien-1-oic acidbeta-D-3-Ribofuranosyluric acidCarbuterol3-[3-(Sulfooxy)phenyl]propanoic acidL-Glutamic acidPiridronic acid1-(3-Carboxypropylcarbamoyl)-5-fluorouracilHexyl glucosideAcefyllineMethyl thiophene-2-carboxylate6-Acetamidohexanoic acidPamidronateDeoxyadenosine triphosphateAnordiol3-(3-Oxobutanoyloxy)butanoic acidThymidine glycolCarnosolic acidHexafluorobenzenePalmitoleic acidFumarycarnitineEremopetasin sulfoxide1-Butyl-3-(pyridine-4-carbonylamino)thiourea6-exo-HydroxyfenchoneSodium hydrogen sulfateVanilpyruvic acidDaumone1-Methylinosine(S)-Norfenfluramine4-Acetyl-2(3H)-benzoxazoloneAlginic acidFamciclovir1-(1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-1h-pyrrole-2,5-dione2-(4-Methyl-5-thiazolyl)ethyl propionateCitpressine IFurazabolPalmitic acid4,7-Dihydroxy-2H-1-benzopyran-2-oneArmillaripinTauro-alpha-muricholic acidBacampicillinAcetamide, 2-(4-(2-((2-hydroxy-3-phenoxypropyl)amino)ethoxy)phenoxy)-N-(2-methoxyethyl)-, (S)-(Z)-5-((2R,3S,4S,6R)-4,6-Dihydroxy-2-((S,E)-3-hydroxyoct-1-enyl)tetrahydro-2H-pyran-3-yl)pent-3-enoic acidbeta-Glycerophosphoric acid2-Amino-3-[[(2R)-2-carboxy-2-(diacetylamino)ethyl]disulfanyl]propanoic acidCDP-DG(18:1(9Z)/22:3(10Z,13Z,16Z))Trifluoroacetaldehyde2-carboxy-L-xylonolactonePhosphonoacetate9-Decenal12-oxo-20-dihydroxy-leukotriene B41-3-(4,5-dihydrofuranone)-5-(hydroxymethyl)-pyrrole-2-carboxyaldehydePentrinitrolHexyl acetateNitroxolineSodium decylbenzenesulfonateAminoparathionSparfosic acidbeta-Caryophyllene alcohol7A-Methyl-19-nortestosterone11-Hydroxyandrosteronep-Hydroxymandelic acidGlucose-6-glutamateRichterPotassium oleatep-Hydroxyphenylacetic acidEdetate disodium3a,4b,7a-Trihydroxy-5b-cholanoic acidIsopetasoside3-Oxo-14,15-dehydrorhazinilam(6R,7R)-6-Methoxy-3,7-dimethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidN,N'-dinitrosopiperazineMethyl 20-dihydroprednisolonate1-Isothiocyanato-3-phenylpropaneBis(4-nitrophenyl) hydrogen phosphateN-Acetyl-D-Glucosamine 6-PhosphateEdrophoniumPotassium oxideResolvin E34-HydroxyhexanoycarnitineUrothionGlucose citrate2-Methyl-2H-1,3-benzoxazin-4(3H)-oneDide-O-methylsimmondsinBalsalazideoctanoatePeonidin-3-glucoside9-Decenoic acidThiethylperazineBenzoic acid sulfate2,5-Octadien-1-olCalamendiol(¡À)-(E)-13-Hydroxy-10-oxo-11-octadecenoic acidAndrostane-3,17-diol 17-sulfateNonadecylresorcinol glucuronideHydroxyphenyllactic acid2-MesatpN-Lactoylphenylalanine(-)-2-DifluoromethylornithineN-Acetylhistidine4-Hydroxyphenylacetylglutamic acid(R)-3-Hydroxy-tetradecanoic acid8-Oxo-dGTPFlufenamic acidCilostazolcyanidin 5-O-beta-D-glucosideXanthineN-Nitrosothiazolidine-4-carboxylic acid6-Hydroxy-2,6-dimethyl-2,7-octadien-4-onePropylparabenSOTERENOLPE-NMe(22:4(7Z,10Z,13Z,16Z)/18:0)L-Glutamine6a,12a-Dihydroxylithocholic acidNifursol2,3-Dihydroxypropyl 4-phenylbutanoate2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol3,4-Methyleneazelaic acid(3alpha,5beta,7alpha)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-beta-D-Glucopyranosiduronic acidElobixibatLafutidine3-[4-methoxy-3-(sulfooxy)phenyl]propanoic acid(Z)-7-[(1R,3R)-3-Hydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]-5-oxocyclopentyl]hept-5-enoic acid{1-[2-(4-Carbamimidoyl-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acidL-arginino-succinate2-Propanamine, N,N,2-trimethyl-1-((3-phenyl-2-quinolinyl)thio)-L-IsoleucineLysoPE(P-18:1(9Z)/0:0)Grevilline A6-Oxopiperidine-2-carboxylic acidDihydrodeoxy-8-epiaustdiolN-lactoyl-MethioninePollenin B1-Hexen-3-olCrotonyl isothiocyanateGluconic acidSinapic acid 4-O-sulfateR-3-(Methylthio)-1-hexanolMenadioneProstaglandin lactone-diolThromboxane A22-FluoroadenineGalactaric acid(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-pyridin-3-yl-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acidSodium n-alkylbenzenesulfonatealpha-D-glucose 6-phosphatePhosphorylcholineBis(2,5-dihydroxypyrrol-1-yl) carbonateUndecanedioic acid2-O-Galloylgalactaric acidLysoPC(15:0/0:0)9-(6-Sulfanylidene-3H-purin-9-yl)-3H-purine-6-thione3,7-Dihydroxy-12-oxocholanoic acidLysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)Ulinastatins-Allyl cysteine sulfoxideTretazicar(E,E)-1,7-Diphenyl-4,6-heptadien-3-ol4,4'-Dipyridyl disulfideSedoheptulose2-NitrophenylhydrazineStatticHexafluoroisopropanolPE(P-16:0/20:4(6E,8Z,11Z,14Z)+=O(5))cis-p-Menthane-1,7,8-triolSetipiprant(6-Aminopurin-9-yl) [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate2-Methylpropyl glucosinolateIsopentyl beta-D-glucosideThromboxane B2JasmoloneCongmuyenoside A(+)-LigballinolCollybialTrona11-Hydroxy-D4-neuroprostaneGlobulol2-Amino-1,3,4-thiadiazoleRiodipineDecarbamoylgonyautoxin III3,7,8,15-Scirpenetetrolp-Aminobenzoic acidN-(2-Hydroxyethyl)-2-(1-isoquinolinylmethylene)hydrazinecarbothioamide5alpha-Pregnane-3alpha,20alpha-diolPradofloxacinBaicalinN-Allylsecoboldine2-Hydroxymyristic acidD-Glucuronic acid 1-phosphate4-O,6-O-Benzylidene-alpha-D-glucopyranosetrans-Carvyl formateLaccarin5-hydroxy-coniferaldehyde13-Hydroxy-9-methoxy-10-oxo-11-octadecenoic acid9(10)-EpODE2-Hydroxypent-3-enenitrileLysoPC(18:3(9Z,12Z,15Z)/0:0)(E)-N-(2-Amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide1H-1,4-Diazepine, hexahydro-1-((5-iodo-1-naphthalenyl)sulfonyl)-2-[(3-Iodophenyl)methyl]-1-[[N'-[(3-iodophenyl)methyl]carbamimidoyl]amino]guanidineAlitameGlutamyltryptophan5-Oxoicosa-3,6,8-trienoic acidCumambrin A3-(4-((3-Phenoxybenzyl)amino)phenyl)propanoic acidCarboquoneCyclo(L-prolyl-L-valyl)1,3,5[10]-Estratriene-2,3-17 beta-triol2-[1-[(2S)-2-[[4-[(E)-N'-Hydroxycarbamimidoyl]benzoyl]amino]propanoyl]piperidin-4-yl]oxyacetic acids-NitroglutathioneMebendazoleAspartame(Z)-7-[(1R,4S,5R,6S)-5-[(E,3R)-3-Hydroxyoct-1-enyl]-2-oxabicyclo[2.2.1]heptan-6-yl]hept-5-enoic acidLamivudine-monophosphate(3E,5Z)-1,3,5-Tridecatriene-7,9,11-triyneMethyl pyruvateLysoPE(0:0/18:1(11Z))2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-onePhenprocoumon4-Ethoxybenzamide5-phosphonooxy-L-lysineBikoeniquinone AO-Succinyl-L-homoserine(6S,7R)-2,6,7,8-Tetrahydroxy-2-oxo-1,3,2lambda5-dioxaphosphonan-5-oneParaoxonMethylphosphateTyrosyl-GlutamateMedica 16triazolobenzodiazepinealpha-Muricholic acid2-Cyanohept-2-enoic acidCysteineglutathione disulfideRanelic acidBenzenesulfonamide, 2-(cyclohexylamino)-N-(((1,1-dimethylethyl)amino)carbonyl)-5-nitro-6-ThioguanosineDeoxycorticosterone2-(4-Methyl-5-thiazolyl)ethyl decanoatetrans-Resveratrol 3,5-disulfateHexaminolevulinateNordihydrocapsiateFlumioxazinImipenemHexafluoroacetylacetone4-hydroxy-2-nonenal-[L-Cys] conjugateDL-AsparaginePentafluoropropanolDioncophylline AVinylpyrazineTriacetic acid1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphateDehydroascorbide(1-)3'-Methyl-4-dimethylaminoazobenzene3, 5-Dihydroxyphenylacetic acidm-Chlorobenzoic acid20-Dihydrodydrogesterone5'-Carboxy-gamma-chromanol3beta-7-Drimene-3,11-diol5-Acetyl-2,4-dimethylthiazoleDifluorodeoxycytidine triphosphatecis-Coutaric acidAmoxicilloylGlutaric acidLysoPC(P-16:0/0:0)alpha,beta-Methylene ATPVeranisatin A11-Deoxy-PGE1para-TrifluoromethylphenolAdenylsuccinic acid3-Hydroxynevirapine glucuronide1-(2-Thienyl)-1,2-propanedioneN-Lauroyl MethionineSebacil8-Hydroxy-5,6-octadienoic acidN-AcetylvanilalanineBaptifoline1,2-Ethanediamine propylene oxide ethylene oxide polymer4H-Thieno(2,3-b)thiopyran-2-sulfonamide, 5,6-dihydro-6-(3-methoxypropyl)-4-(propylamino)-, 7,7-dioxide, (4S,6S)-Sodium acetateSodium calcium edetate3-HydroxyphenyllactateGalactocerebroside3'-SialyllactoseOsmanthuside AChlormidazolebeta-nicotinate D-ribonucleotide(2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl) hydrogen sulfate[(5-methyl-1,3-dithiolan-4-ylidene)amino] N-methylcarbamate2-Ethyl-2-Hydroxybutyric acidStrictinin1,1,1-Trifluoro-2,4-pentanedioneS-Acetyl dihydroasparagusic acidPhosphonate analog5,15-DiHETEDifluorodeoxycytidinebeta-D-fructose 2,6-bisphosphate2-Methylbutyl 3-hydroxy-2-methylidenebutanoateDiethylphosphate8-AzaguanineIsovaleric acid3,4-Bis(carboxymethyl)-3,4-dihydroxyhexanedioic acidOctafluorocyclobutaneTrimethoprim1-PalmitoylphosphatidylcholineNoberastine3-Methoxy-4-Hydroxyphenylglycol sulfate5,6-Epoxy-13-cis-retinoic acid4,4'-methanol-bisbenzonitrile1,2-Ethanediol monoricinoleateOleoyltaurineNeuromedin B (1-3)a-Hydroxyprogesterone(6E,8E,10S,12Z)-10-Hydroxy-3-oxooctadecatrienoic acid5-(4-Hydroxybenzyl)thiazolidine-2,4-dioneIsoferulic acid 3-sulfateLysoPE(0:0/20:5(5Z,8Z,11Z,14Z,17Z))Hexadecanedioic acid2-Amino-5-[[1-[carboxymethyl(2-hydroxypropanoyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acidBenzenebutanesulfonic acid, 3-phenoxy-alpha-phosphono-, (alphaS)-(3E,5E,8Z)-Deca-3,5,8-trienedioylcarnitine1-Methyl-2-n-hexylbenzeneribostamycin6-(Pyridin-3-YL)hexanoic acidLapachenoleSuprofen S-oxideLysoPE(0:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))S-(Formylmethyl)glutathione1-Octanesulfonic acidOctadec-5-enoic acidDimethylguanidino valeric acid(+)-BottrospicatolPyrophosphateBictegravir19-Hydroxyprostaglandin E1Perfluorotetradecanoic acidUridine9S-hydroxy-11,15-dioxo-5Z,13E-prostadienoic acidPropionic acid, 2-methyl-2-((piperidinomethyl)thio)-ApigenidinBenzhydrylaminePC(2:0/18:1(12Z)-2OH(9,10))2,2,7,7-Tetramethyl-1,6-dioxaspiro[4.4]nona-3,8-diene[4-[4-(4-Hydroxyphenyl)hex-3-en-3-yl]phenyl] phosphono hydrogen phosphateMoxisylyteLysoPE(0:0/20:3(11Z,14Z,17Z))4-Nitrophenyl 2-propylmethylphosphonatePBD dimerCDP-DG(18:2(9Z,11E)+=O(13)/i-19:0)4,7(11)-Guaiadien-8-onePhenylalanyl-GlycinePhosphoribosyl formamidocarboxamideTrisodium nitrilotriacetateBenzoyl phosphate6-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydroimidazo[1,2-c]pyrimidin-5-onePhosphatidylinositol 4,5-diphosphateFamitinib(2-Methylphenyl) Dihydrogen PhosphateO-Coumaric acid sulfateSchisanhenolIsoketocamphoric acidIsoxanthopterinEnol-3-Ethyl-1,2-cyclopentanedioneLysoPI(16:0/0:0)Thioperamide4-(3-Hydroxybutyl)-3,3,5-trimethylcyclohexanoneN'-[(4-Oxo-4H-chromen-3-yl)methylene]nicotinohydrazideCytosine arabinose-5'-phosphateRibose 1-phosphate6-Keto-prostaglandin F1a5-Hydroxyindoxyl sulfate3-Nitrotyrosinetrans-Propenyl propyl trisulfide3,4-Dihydroxyphenylvaleric acid 4 sulfateAlongsideTetrahydrogestrinone(S,S)-Nt-HistidinylalanineAcarboseDocosapentaenoic acid (22n-6)4,4'-BipyridinePropoxurN-(1-Carboxy-3-carboxanilidopropyl)alanylprolineN-Acetyl-L-glutamic acid(E,E)-Boviquinone 3Tafluprost free acidLysoPC(0:0/20:4(5Z,8Z,11Z,14Z))5-Cholesten-3beta-25-diol-3-sulfateAmrubicinDibutyl sulfosuccinateValyl-prolyl-glycyl-valyl-glycine1-Methoxy-1-(2,4,5-trimethoxyphenyl)-2-propanolL-TyrosineFumaric acidN1,N10-DiferuloylspermidinePC(22:6(4Z,7Z,11E,13Z,15E,19Z)-2OH(10S,17)/2:0)(Z)-3-Oxo-2-(2-pentenyl)-1-cyclopenteneacetic acidAveninSulfoacetic acid6-(3-((S)-1-Methoxypropan-2-yloxy)-5-((S)-1-phenylpropan-2-yloxy)benzamido)nicotinic acidKinetensin 1-3LysoPC(18:4(6Z,9Z,12Z,15Z)/0:0)N-Acetylmannosamine-6P3,5-Dinitrosalicylic acid4-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylaniline2,2,4-Trimethyl-1,3-dioxolaneBenzo[d][2]benzazepine-5,7-dioneMalonylglycinexanthurenic acid 8-O-sulfateGibberellin A882-Mercapto-3-phenylthieno[3,2-d]pyrimidin-4(3H)-oneArginylhistidine2-Fluorobutyl 2-(8-azabicyclo[3.2.1]octan-1-yl)-5-iodobenzoateNicotinic acid ribonucleoside2beta-HydroxytestosteroneN-acetyl-S-(N-allylthiocarbamoyl)-L-cysteineAtractylenolide IIEcabetPyrroloquinoline quinone{[5-(5-Nitro-2-furyl)-1,3,4-oxadiazol-2-YL]thio}acetic acid7-Hydroxy-R-acenocoumarolFallyprideEnprofyllineArginyl-Gamma-glutamateAmantadineLysoPE(20:4(5Z,8Z,11Z,14Z)/0:0)Hydroxytyrosol 3'-sulfateVoxelotor4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone13-HODE3-Nitro-2-nitrooxybenzoic acidSpectinomycinAvocadyne 1-acetatealpha-Methoxy-1H-indole-3-propanoic acid4-Hydroxyretinoic acid15-(4-Iodophenyl)-3,3-dimethylpentadecanoic acid(8R,9S,10S,13S,14S,17S)-17-Hydroxy-10,13-dimethyl-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-2,3-dione7-Hydroxyoctadecanoic acidcis-3-Hexenyl salicylatePerfluorohexanoic acid[3-Methoxy-2-phosphonooxy-6-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphateEntacaponeSusalimodOR-1855(2R,4S)-2-Aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dioneSufentanilDihydroisophorolDocosapentaenoic acid (22n-3)SorbinilMethyl acrylate-divinylbenzene, completely hydrolyzed, copolymer3beta,7alpha-Dihydroxychol-5-en-24-oic AcidSuberic acidPamaquineHomolanthionineIndole-3-carboxilic acid-O-sulphateAcetamide, N-[4-[[(aminothioxomethyl)hydrazono]methyl]phenyl]-3-Indole carboxylic acid glucuronide3-Quinuclidinyl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate4-NitrophenolEquol 4'-O-glucuronideHydroxyacetoneHept-4-enedioylcarnitinePhenylmethanesulfonamideN-acetylglutamyl-phosphategamma-Glutamyl-5-hydroxytryptophan4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane(3R,5Z)-5-Octene-1,3-diolVicrivirocRitalinic acidmethoprolol2,6-DiaminopurineBenzo(1,2-b:4,3-b')dipyrrole-2-carboxylic acid, 3,6,7,8-tetrahydro-6-(aminocarbonyl)-5-hydroxy-4-methoxy-Calcium citrate1-(6-Aminopurin-9-yl)-5-methylpyrimidine-2,4-dionePS(22:5(7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))IndecainideDesacetycefapirinErinacine DPrimisulfuron-methyl3-[(1R,2R,3S)-3-Carboxy-1,2,3-trihydroxypropyl]dioxirane-3-carboxylic acidMonomenthyl succinate1-O-Hexadecyl-sn-glycero-3-phosphocholine4-[(4-Aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline(+)-Chebulic acid17-Iodoheptadecanoic acidSodium lactatePolyethylene, oxidizedTolcaponeGibberellin A11612-KETEMegazolLactose citrate(+)-Norgestrel5-(3-Hydroxybenzoyl)-2-thiophenesulfonamide3,4-Dimethyl-5-propyl-2-furantridecanoic acid4-phenylbutanic acid-O-sulphate1,3-DioxoleTalaromycin AGolvatinib3-Hydroxy-3-phenylpropanoic acid2-Methylthio-adenosine-5'-diphosphateBenzamide, N-[2-[4-(cyclopropylcarbonyl)-3-methyl-1-piperazinyl]-1-[[7-(1,1-dimethylethyl)-1H-indol-3-yl]methyl]-2-oxoethyl]-4-nitro-4-Amino-5-ethylthiophene-3-carboxylic acidLinoleoyl ethanolamideLysoPC(0:0/16:0)Sterebin GTheobromine3b-Hydroxy-17-(1h-1,2,3-triazol-1-yl)androsta-5,16-diene5-[(1-Iminoethyl)amino]-2-aminopentanoic acidSterebin C(2R)-2-Amino-6-[[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl]amino]hexanoic acid(1S,2S,3S,4R)-3-(1-Acetamido-2-ethylbutyl)-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acidAbeado[3-[1-Formyl-2-(2-furanyl)ethenyl]]-2-(2-furanyl)-5-(2-furanylmethylene)-4,5-dihydro-a-methyl-4-oxo-1H-pyrrole-1-acetic acid, 9CIPiperolactam DMitoxantrone2-(Phosphonomethyl)pentanedioic acid2-Hydroxy-6-(8-tridecenyl)benzoic acid7alpha,17beta-Dihydroxyandrost-4-en-3-oneLanthionine ketimineEthyladipic acidBENSULIDEEthylenediaminetetraaceticacid2-Hydroxy-3-methylbutyric acid2,2,2-TrifluoroethylROXATIDINEArginylasparagineSodium cyclamate2-Methoxyacetaminophen glucuronideMenthol-glucoronidePentafluoroethaneSeminaphtharhodafluorNitrosobenzene6-Thioxanthine(Z)-4-Methoxy-3,3',5,5'-tetrahydroxystilbenePhosphoserinePrinomide8-O-MethyloblongineBicyclo[3.1.1]hept-2-ene-2-acetaldehyde, 6,6-dimethyl-Picrosid II, HPLC GradeImazamethabenz-methyl5,10-Pentadecadien-1-olPC(2:0/PGE1)Pyridoxine 5'-phosphateBenzenesulfonamideDazmegrelLysoPE(P-18:0/0:0)Piperonyl sulfoxide15-(4-Iodophenyl)pentadecanoic acidMetomidateTrifluoroethylene2-C-methyl-D-erythritol-4-phosphate(2,2-Diethoxyethyl)benzenePhosphatidylglycerol2-Hydroxyoctadecanoic acidCholylaspartic acid2-Benzyl-5-hydroxymethyl-1,3-dioxolane5beta-Pregnane-3alpha,20alpha-diolSPARSOMYCINErinapyrone A9-Oxo-10,12-octadecadienoic acidErinapyrone Btrans-4-Hydroxycyclohexylacetic acid1-Ethoxymethyl-5-fluorouracilScorzosideSevofluraneDihydroxyacetone Phosphate Acyl EsterPE(18:2(9Z,12Z)/18:0)HydroxyzineCalcium sorbatePS(20:4(8Z,11Z,14Z,17Z)/18:0)TazobactamTridecanalEperezolid(¡À)-threo-Anethole glycolPS(18:2(9Z,12Z)/18:0)2-Anthraquinonesulfonic acidb-D-Xylopyranosyl-(1->4)-a-L-rhamnopyranosyl-(1->2)-L-arabinoseProgesteroneEprodisate(2R,3R)-3,3',4',7-Tetrahydroxyflavanone 7-O-alpha-L-RhamnopyranosideKetanserin1,2-Dimethoxy-13-methyl-[1,3]benzodioxolo[5,6-c]phenanthridine2-Ethoxy-6(5-tetrazolyl)xanthone1H-Imidazole-4-carboxamide, 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-2,5-Dihydroxycinnamic acid methyl ester3-carboxy-4-methyl-5-pentyl-2-furanpropanoic acid(2-Amino-6-oxo-1H-purin-9-yl) dihydrogen phosphate2-Methylthioadenosinecis-3-Hexenyl benzoatePralidoxime2,6-Nonadien-1-olGlycyl-Tryptophan2-Nitrofuran1,11-Undecanedicarboxylic acidAspartyl-MethionineBay-41-85435-Fluoromethylornithine1-Heptanesulfonic acidSuprofenAjmaline2,3-Dihydroxy-2-methylbutanoic acid5-Methylthioribulose 1-phosphate1-MethylpyrrolidinePC(17:2(9Z,12Z)/0:0)Dihydrohydroxy-O-methylsterigmatocystinMyxinFenitrothion(2R,3R,4S,5R)-5-Fluoro-2,3,4-trihydroxy-6-oxohexyl dihydrogen phosphatePentafluorobenzene4-Hydroxy-2,6,6-trimethyl-3-oxo-1,4-cyclohexadiene-1-carboxaldehydeT2 TriolArgentineS-(PGA2)-glutathioneGuggulsteroneN-Methylphenylalanyl-prolyl-arginineMethyl bisnorbiotinyl ketoneFlavogallolSodium thiosulfate5'-N-MethylcarboxamidoadenosineSodium Tetradecyl SulfateRicinoleic acidNb-MethyltetrahydroharmolCinncassiol ASulfapyridineD-MannoseCDP-N-methylethanolamineGuanosine 2',3'-cyclic phosphateAsparagine glutamategamma-Glutamylglutamic acid4-Amino-1,2,4-triazole2-EthylbenzenethiolPhosphate[(2S,3R,4R,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateAloinoside BLysylglycine1',2'-Dihydro-1,1'-dimethyl-2'-oxo-4,4'-bipyridinium(1+)Capillin3-Methylcrotonylglycine4-Piperidinol, 1-(3-phenothiazin-10-ylpropyl)-4-HydroxytoremifeneMonocyclohexyl phthalateEthyl menthane carboxamide2-C-methyl-D-erythritol-2,4-cyclodiphosphateLithocholic acid glucuronideDiglyceridePhenylacetylglycine3-MethylcyclopentadecanoneLysoPE(0:0/20:3(8Z,11Z,14Z))cannabigerolate2-(3-Mercaptopropyl)pentanedioic acidHPAA sulfateEstrone glucuronide3,4-Dimethyl-5-propyl-2-furanpentadecanoic acid1,2,3,4-Tetrahydro-b-carboline-1,3-dicarboxylic acidEtamiphyllineS-JaponinTetramineSpermic acid 21-[(2R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-2-pyrimidinone(+)-Angelicoidenol15(R)-hydroperoxy-EPESiguazodan2-O-(6-Phospho-alpha-mannosyl)-D-glycerate1,2-Dioxetane2,3,4,5-Tetrahydroxy-6-(1,2,3,4-tetrahydroxybutyl)oxane-2-carbaldehydeNiflumic AcidCalcium gluconateD-4'-PhosphopantothenateLysoPC(18:3(6Z,9Z,12Z)/0:0)(3R)-10,13-Dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-olSodium phosphate (Na(H2PO4))18-Nitrooctadeca-9,12-dienoic acidNilutamideCannabidivarinPentafluorophenylhydrazinePerfluorodecalinPolymaleic acid, sodium saltPerfluoroisobutyleneDhelwangin(-)-Mintlactone10,11-dihydro-12-oxo-LTB4Pyrazolopyrimidinone4-Dodecylbenzenesulfonic AcidFluvastatin13,14-Dihydro PGF2a1-Piperidinyloxy, 4-(((dodecyloxy)hydroxyphosphinyl)oxy)-2,2,6,6-tetramethyl-DimetridazoleIodiconazoleDopamine 4-sulfateIndoleacrylic acidLewis b5,9:6,9-Diepoxy-4-megastigmeneAsparaginyl-PhenylalanineEmtricitabineChenodeoxycholyltaurineMibefradil8,13-Abietadien-18-oic acid5-(Methoxycarbonyl)thiophene-2-carboxylic acidMurametide19-hydroxyprostaglandin H2(1-)PC(DiMe(9,5)/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))isoxazolyl penicillin1-Methyl-5-(4-benzoyl)pyrrole-2-acetic acid 2-(theophylline-7-yl)ethyl esterAllodesmosineIsomazoleArhalofenate(9S,10S)-9,10-dihydroxyoctadecanoate2-(2-Thienylmethylene)-1,6-dioxaspiro[4.4]non-3-ene3,5-Dinitrocatechol2-OxomelatoninGibberellin A53DihydrocitrinoneCevimelineLevan(1R)-1-Amino-2-sulfanylethanesulfinic acidSuccinic acidN-[[3-Hydroxy-2-(2-pentenyl)cyclopentyl]acetyl]isoleucineTemozolomideAnnuionone BPsilocybine19-Oic-deoxycorticosterone3-DeazaadenosineL-ArginineDisulfurPI(22:3(10Z,13Z,16Z)/20:4(8Z,11Z,14Z,17Z)-2OH(5S,6R))7-Nitro-2,3-Dioxo-2,3-Dihydroquinoxaline-6-CarbonitrilePerindopril Acyl-beta-D-glucuronideN-Acetyl-DL-phenylalanineHippuric acidTRIFLUOROMETHANOLPE(18:0/20:4(5Z,8Z,11Z,14Z))LysoPC(0:0/18:0)Benorilate(4S,8R)-8,9-Dihydroxy-p-menth-1(6)-en-2-oneMoracin L1-Octen-3-yl acetateDexpramipexoleTheasaponin A4LysoPG(18:2(9Z,12Z)/0:0)Pantoprazole SulfoneNnal-N-oxideIsohumulone A3-deoxy-D-arabino-heptulosonate-7-phosphateIsoprostane F2alpha-I4-Phenylbutyl glucosinolateMethocarbamolDe-O-methylsimmondsinGibberellin A1710,11-dihydro-leukotriene B44-Amino-5-hydroxy-1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-onezardaverineCenthaquinethienodiazepineArmillatinLysoPE(0:0/20:4(5Z,8Z,11Z,14Z))MG(LTE4/0:0/0:0)hydroxynonenal1-O-GalloylglycerolFAD2'-PhosphophloretinAllo-hydroxycitric acid lactoneOrthoperiodic acidBrevifolincarboxylic acid7-(3-Isothiocyanatopyrrolidin-1-yl)-N,N-dimethyl-2,1,3-benzoxadiazole-4-sulfonamide1-pentadecanoyl-glycero-3-phosphate3-DehydronobilinEchothiophateLysoPC(16:0/0:0)All trans decaprenyl diphosphateCifostodinePhenolsInosineDG(i-14:0/0:0/PGE2)D-Lactic acidKanzonol N(S)-a-Amino-2,5-dihydro-5-oxo-4-isoxazolepropanoic acid N2-glucoside1-Hexadecene1-Nitro-3,5-dinitroso-1,3,5-triazinaneAnofinic acid6-Hydroxy-3,4-dihydro-2(1H)-quinolinone2-Phenylethanol glucuronideN-(1,3-Dihydroxyoctadec-4-en-2-yl)acetamideMethylphenobarbitalIsoxaflutoleCyclopentanecarboxylic acidOuabainHomomangiferinCholic acidLucidenic acid L(3S)-3-hydroxycyclocitralDiphenylhydantoic acid2,4-Dinitroanisole5-Sulfo-1,3-benzenedicarboxylic acidGentiopicrosideN-Choloylglycine1,3-Bis(hydroxymethyl)-3-methylbicyclo[2.2.1]heptan-2-one[2,2'-Biquinoline]-4,4'-dicarboxylic acidChrycorinNitroglycerinUDP-alpha-D-xylose1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxypyrimidin-2-oneUDP-L-arabinose3-Oxo-4,6-choladienoic acid2-O-Glutaroyl-1-O-palmitoyl-sn-glycero-3-phosphocholineGlycyl-prolyl-arginyl-valyl-valyl-glutamic acid2-Aminoacrylic acid2,6-Diamino-9-(2-hydroxyethoxymethyl)purineTarazepidealpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanolN-(1-Deoxy-1-fructosyl)leucineArsenobetaineMethylenecyclopropylglycineN-AcetylprolineN-Palmitoyl SerinePropyl 2-methylpropanoateUDP-D-galacturonic acidDiltiazemSebacic acidL-Methionine6-isobutyl-4-hydroxy-2-pyroneEtheno adenosine triphosphate(+/-)-DihydrofarnesolTalipexolePG(20:3(5Z,8Z,14Z)-O(11S,12R)/18:1(11Z))Methyl parathionHomovanillic acid sulfateD-Malic acidUDP-alpha-D-galactoseBovinic acidAlaptidePA(18:1(9Z)/16:1(9Z))CapecitabineL-Cysteinylglycine disulfidePolygonalPerfluoro(methylcyclohexane)5-(2-Hydroxyethyl)-4-methylthiazoleL-Menthyl (R,S)-3-hydroxybutyrate2'-Deoxy-5'-O-thiophosphonouridine6-NitrotryptophanN-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]ureaAnacardic acidtrans-S-(1-Propenyl)-cysteine disulfide(2RS,5RS)-(E)-2-(2-Phenylethenyl)-1,3-dioxan-5-olSodium glucoheptonateTizoxanide glucuronidehesperetin 3'-O-sulfateMethylgeranatePrephenate(2E)-2-{6-[(E)-2-Carboxyethenyl]-2,3-dihydroxyphenyl}-3-(3,4-dihydroxyphenyl)prop-2-enoic acidPerflubutaneSobrepinLysozyme7-Hydroxyethyl biscoumacetate5-Hydroxy-1-(3-hydroxy-4-methoxyphenyl)decan-3-one1-IodopentaneDodecanedioic acidFurylfuramide3-(3,4-Dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl)prop-2-en-1-oneS-AdenosylmethionineIomeprolIODODIFLUNISALBL IIGlutamylleucylarginineOleosideN-Acetyl-L-alanine2,4-Dihydroxybenzoic acidL-ThymidineOryzalic acid A10-Undecen-1-olTanshinone IIA5-Hydroxy-2-imino-1-methylimidazolidin-4-one13,14-Dihydro-15-oxo-lipoxin A4Phosphodimethylethanolaminethiol-maleimide(4-Hydroxy-3-iodo-5-nitrophenyl)acetic acidCrosatoside BCamostatThymidineMethoxymorpholinyldoxorubicinValerenolic acid(2R,3R,4S,5S,6R)-2-(3-(4-Cyclopropylbenzyl)-4-fluoro-1H-indol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triolSofalconeIsosorbide DinitrateProstaglandin B-17,8-Dehydro-3,4-dihydro-beta-ionolFlubendazolePolystyrene sulfonatePirarubicinOrotic acidPGP(22:6(4Z,7Z,10Z,12E,16Z,19Z)-OH(14)/i-12:0)Vitamin D3 sulfatebeta-(2-Methoxyphenoxy)-lactic acid3-(4-Hydroxy-3-methoxyphenyl)-1,2-propanediolNicotinamide N-oxideIsoursodeoxycholic acidAzaperonedIDPLysoPE(16:0/0:0)N-desethylamiodarone(2R)-2-Hydroxy-2-phenylethyl glucosinolateGlycylprolylarginineCalcium acetateDeclopramideCidofovirDimethyl-3-hydroxypyrid-4-oneCreatinine nitrite nitrate10-Undecen-2-oneCarboxin6,15-Diketo-13,14-dihydro-PGF1alphaMethylarsoniteN-AcetyltyrosineTrue blue4-Oxo-1-(3-pyridyl)-1-butanone2-Pentylthiophene9,10,13-Trihydroxystearic acidAtglistatin3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-olPS(6 keto-PGF1alpha/14:0)O-Phosphothreonine6-Dimethylaminopurine2-(Arabinosylamino)-3-(glucosylamino)propanenitrile(1Z,4Z)-1,5-bis(4-hydroxyphenyl)-1,4-pentadiene20-Hydroxypregn-4-en-3-oneWithaphysacarpinn-octyl-beta-D-thioglucopyranoside2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-6-(2-Hydroxyethoxy)-6-oxohexanoic acidMitragynineP-Hydroxyhippuryl-his-leu-OHAllantoic acidHeptafluorobutyric acidTaurodeoxycholic acid3-Oxotetradecanoic acidO-Ethyl S,S-diphenyl phosphorodithioateMethylpyrogallol sulfate 3Azelaic acid2,5-DimethyltetrahydrothiopheneDihomo-alpha-linolenic acid3,7-Dihydroxydecanoylcarnitine2-Carboxy-4-dodecanolidePefloxacin N-oxideNigellidineDihydroxy-(2-methoxyethoxy)-sulfanylidene-$l^{5}-phosphane(3E)-HexenoylcarnitinePYROMELLITIC ACID6-Cyano-7-nitroquinoxaline-2,3-dioneDecarbamoylsaxitoxin5alpha-Tetrahydrocortisol4-Chloro-L-phenylalanineO-TerphenylAvocadeneDeoxyadenosine monophosphatePancrelipase1,2-Difluoro-3,4-dinitrobenzene1-[2,3-Dimethyl-2-(2-methylbut-3-en-2-yl)furan-3-yl]-3,5-dihydroxy-4-methoxyhexan-2-oneStepronin6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone2-(3-Hydroxy-1H-indol-2-yl)acetic acid8-[3-[1-[(3-Fluorophenyl)methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline-4-one4-Methylumbelliferone glucuronideGlycine formateValylprolineMethyl-4-hydroxybenzoate sulfateD-fructose 6-phosphateN-(1-Deoxy-1-fructosyl)threonine3-(3-Methylbutylidene)-1(3H)-isobenzofuranoneSodium potassium tartrateLeonoside APicroside I2-Phenyl-1,3-dioxolane-4-methanol3,5-Dinitrobenzoic acidfalseDendrobium officinale Polysaccharide Ameliorates High-Fat Diet-Induced Hepatic Lipid Metabolic Disorder via the SIRT6/PGC-1α Signaling AxisAims: This study aims to explore the potential therapeutic effect of Dendrobium officinale polysaccharide (DOP) on non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD), and to elucidate the underlying mechanism involving the SIRT6/PGC-1α signaling axis and the regulation of the gut microbiota. Methods: We extracted and characterized DOP. We established a rat model of NAFLD induced by HFD and evaluated the efficacy of DOP by integrating multi-omics techniques (transcriptomics, metabolomics) and 16S rRNA sequencing. To verify the specific role of SIRT6, we introduced the SIRT6 inhibitor OSS_128167 in the primary hepatocyte model induced by oleic acid/palmitic acid (OA/PA). Results: DOP significantly alleviated liver steatosis, oxidative stress, and lipid metabolism disorders induced by HFD. Multi-omics analysis indicated that DOP regulated liver glycerophospholipid metabolism and restored intestinal microbiota homeostasis, significantly increasing the abundance of beneficial bacteria such as Lactobacillus. Mechanistically, DOP activated the liver SIRT6/PGC-1α signaling axis, thereby enhancing antioxidant defense and inhibiting lipogenesis. Crucially, in vitro experiments confirmed that the SIRT6 inhibitor OSS_128167 eliminated the protective effect of DOP on lipid accumulation, confirming that the effect of DOP depends on SIRT6. Conclusion: DOP improves NAFLD through dual mechanisms of regulating the gut-liver axis homeostasis and directly activating the liver SIRT6/PGC-1α signaling pathway. The results of this study provide a theoretical basis for developing DOP as a drug for the treatment of NAFLD.2026-05-252026-05-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