MetaboLights

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ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14628/m_MTBLS14628_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14628/m_MTBLS14628_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14628/s_MTBLS14628.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14628/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14628/a_MTBLS14628_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14628/a_MTBLS14628_LC-MS_positive_reverse-phase.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14628Metabolite identification was performed using MSDIAL software. The extracted features were annotated by accurate mass matching with a mass tolerance of <10 ppm and MS/MS spectral matching with a mass tolerance of <0.01 Da. The annotation was conducted against public metabolite databases, including HMDB, MassBank, and GNPS, as well as the in-house Bioprofile metabolite standards database (BP-DB).MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseChromatographic separation was performed using a SHIMADZU-LC30 ultra-high-performance liquid chromatography system. Samples were analyzed on an ACQUITY UPLC HSS T3 column (2.1 × 100 mm, 1.8 μm; Waters, Milford, MA, USA). During analysis, the samples were maintained in the autosampler at 4°C. The injection volume was 4 μL, the column temperature was 40°C, and the flow rate was 0.3 mL/min. Mobile phase A was 0.1% formic acid in water, and mobile phase B was acetonitrile. The gradient elution program was as follows: 0–2 min, 0% B; 2–6 min, 0–48% B; 6–10 min, 48–100% B; 10–12 min, 100% B; 12–12.1 min, 100–0% B; and 12.1–15 min, 0% B.Genetic Ablation of Sfxn5 Induces Mitochondrial Dysfunction and Precipitates Lethal Metabolic Crisis in Mice.Peking UniversityDuo KeaiLiverbrainmass spectrometry assayTissue samples were thawed at 4°C, and 50 mg of each sample was transferred into an EP tube. Three medium steel beads and 200 μL of pre-cooled 80% methanol aqueous solution were added, and the samples were homogenized using a tissue disruptor. Subsequently, 800 μL of pre-cooled 80% methanol aqueous solution was added, followed by ultrasonic extraction in an ice bath for 20 min. The samples were then incubated at 20°C for 1 h and centrifuged at 16,000 × g for 20 min at 4°C. The supernatant was collected and dried using a high-speed vacuum concentrator. Before mass spectrometry analysis, the dried extracts were reconstituted in 100 μL methanol/water solution (1:1, v/v), centrifuged at 20,000 × g for 15 min at 4°C, and the supernatant was used for analysis.Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS14628Chunguang Ren. Chongqing Medical University. chunguangren@cqmu.edu.cn.Huan Zhang. Chongqing Medical University. 191109@hospital.cqmu.edu.cn.Raw data were processed using MSDIAL software for peak alignment, retention time correction, and peak area extraction. Metabolite annotation was performed by matching accurate mass with a mass tolerance of <10 ppm and MS/MS spectra with a mass tolerance of <0.01 Da against public databases, including HMDB, MassBank, and GNPS, as well as the in-house Bioprofile metabolite standards database (BP-DB). Ion peaks with more than 50% missing values within a group were removed before statistical analysis. Positive- and negative-ion data were normalized separately by total peak area, integrated, and then analyzed using Python software. The data were preprocessed by unit variance scaling before subsequent data analysis.Groupkeaiduoduo998@126.comBrain and liver tissues were harvested from WT and Sfxn5-knockout mouse pups at postnatal day 26. Samples were immediately snap-frozen in liquid nitrogen after collection and stored at 80°C until analysis. Six biological replicates were analyzed for each tissue and genotype group, including WT brain, Sfxn5-knockout brain, WT liver, and Sfxn5-knockout liver. Prior to metabolite extraction, tissue samples were thawed at 4°C, and approximately 50 mg of each sample was processed.MetabolomicsMetabolomicsSHIMADZU-LC30 UHPLCMus musculusuntargeted analysisLiverUrea cycletissueMetabolismbrainSfxn5Hepatic metabolic crisisMitochondrial disorderThermo Scientific QE PlusMetabolomicsSHIMADZU-LC30 UHPLCMus musculusuntargeted analysisLiverUrea cycletissueMetabolismbrainSfxn5Hepatic metabolic crisisMitochondrial disorderThermo Scientific QE PlusMass spectrometric analysis was performed using a QE Plus mass spectrometer (Thermo Scientific) equipped with a HESI source. Each sample was analyzed in both positive and negative electrospray ionization modes after UPLC separation. The ionization parameters were as follows: spray voltage, 3.8 kV in positive mode and 3.2 kV in negative mode; capillary temperature, 320°C; sheath gas, 30; auxiliary gas, 5; probe heater temperature, 350°C; and S-lens RF level, 50. The mass spectrometry acquisition time was 15 min, and the precursor ion scan range was 70–1050 m/z. The MS1 resolution was 70,000 at m/z 200, with an AGC target of 3e6 and a maximum injection time of 100 ms. For MS/MS acquisition, the 10 most intense precursor ions were selected for MS2 scans after each full scan. The MS2 resolution was 17,500 at m/z 200, with an AGC target of 1e5, a maximum injection time of 50 ms, HCD activation, an isolation window of 2 m/z, and stepped normalized collision energies of 20, 30, and 40.2-((3-ethoxy-3-oxopropanoyl)oxy)-N,N,N-trimethylethan-1-aminium6-Methoxy-pyridine-3-carboxylic acidSpectral Match to Phe-Tyr from NIST14Plantagoninep-Mentha-1,3,5,8-tetraeneCorticosteroneOct-5-enedioylcarnitineOroxin BN-Fructosyl isoleucineGuaiacolEctoine2,5-Dimethyl-3-hexyne-2,5-diolAlbuterol(2S,4R)-4-hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acidCitrulline1,5-Naphthalenediamine2,3-Dimethyl-2-cyclohexen-1-one2-(2-aminoacetamido)-3-methylpentanoic acid5-Hydroxy-DL-lysineSpectral Match to Phe-Pro from NIST14AdemetionineN-Benzoyl-L-glutamic acidCyclopentylamineProstaglandin E27b,9-Dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9ah-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetateCyclododecalactamSpectral Match to Lys-Ile from NIST142,4-Thiazolidinedicarboxylic acid, 2-methyl-ArginineFusaric acidPhenylalanine methyl esterDimethylaminopropyl Lauramide2,8-DihydroxyquinolinePhenylalanylserineFMNUnknown (carbon number 7)12,13-Dhomegamma-GlutamylphenylalanineLidocaineKainic acid2-Cyclopenten-1-onePantothenic acid1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholineXanthurenic acidProstaglandin F28aBicifadinebeta-Ureidoisobutyric acidN-Acetylmethionine, DL-Acetoacetic acidLeucyl-LeucineGlycylvalineIndole-3-acetyl-alaninePolyornithine4-Methylphthalic anhydrideSpectral Match to Leu-Thr from NIST14Pyridine4-HydroxyquinolineSpectral Match to Eicosapentaenoyl PAF C-16 from NIST141-Stearoyl-2-linoleoylphosphatidylcholineO-Propanoyl-D-carnitineN-acetyl-d-tryptophanSpectral Match to Ser-Val from NIST14(1r,3r)-1-Aminocyclopentane-1,3-dicarboxylic acidN-ValyltryptophanSerine8,12-Octadecadienoic acid4-MethylbenzaldehydeGlutathione (oxidized)Leucyl-alanineIsocitric acidDibutylamineN,N-Dimethyl-N-decylamineFuranone ANon-3-enoylcarnitineLPC(18:1)5-(2H-benzo[3,4-d]1,3-dioxolen-5-ylcarbonylamino)-2-(methylamino)-1,3-thiazole -4-carboxamideTridec-8-enoylcarnitine5-AcetoxyindoleProstaglandin B12-HydroxypurineMethylene-imidazole1-Pentyl-3-(1-naphthoyl) indolemethyl 1-methylpiperidine-3-carboxylateSpectral Match to Arachidonoylthio-PC from NIST143-(beta-D-Glucopyranosyloxy)-7-(alpha-L-rhamnopyranosyloxy)-5-hydroxy-4'-methoxyflavoneStearic acid amideFructosyl-lysineDodecanamideethyl 2-[(ethoxycarbonyl)carbonylamino]benzoatePseudo-anisatinValylvaline4,1-Benzoxazepine4-Aminobutyraldehyde6beta-HydroxycortisolPropionyl-L-carnitineSphingosineGlyceryl monostearateMalonylcarnitine1-Lauroyl-2-Hydroxy-sn-Glycero-3-Phosphocholinegamma-Glutamylleucinegamma-Glutamylmethionine1H-Pyrrole-2-carboxaldehydeAgelasineE/FL-IsoleucineL-IsoleucineL,L-Cyclo(prolylalanyl)L-CystathionineLysineIsoleucylserineAICARTyrosylleucine2-Pyrrolecarboxylic acidGuanine17Alpha-hydroxy progesterone4-[5-[[4-[5-[Acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentylamino]-4-oxobutanoic acidNepsilon,nepsilon,nepsilon-trimethyllysineDehydrocostus lactoneN-AcetylphenylalanineXanthosinePerseitol3,4-DiaminopyridineCitric acidGlycylleucineRetinolIsospaglumic acid3-Formyl-6-hydroxyindole(2E,4E)-Octadeca-2,4-dienoylcarnitineN-Acetyl-L-arginineSpectral Match to Ile-Gly-Ile from NIST143-Hydroxybenzyl alcoholNAD+Desogestrel2,6,10,14-Hexadecatetraenoic acid, 3,7,11,15-tetramethyl-, (Z,E,E)-Benzeneacetonitrile(aS,5S)-MetolachlorLeucyl-GlutamineSpectral Match to Thr-Leu from NIST14Indole-3-acrylic acidC9H8O2Phenylalanyltryptophan3,4,5-Trimethylbenzaldehyde2-Aminoethyl oleateGlutathione (reduced)2-(2-Aminopropanylamino)-4-carbamoylbutyric acid5,5-Dimethyl-2(5H)-furanone4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]butanoic acid6-Hydroxynicotinic acid5-hydroxycalamenene5-Hydroxymaltol2-PyrazinoylguanidineAnandamideHydroquinoneBisphenol ATryptophan methyl esterBenzofuranSpectral Match to 15-HEDE from NIST144-Hexanolide1,2-DihydroquinolineProstaglandin I3dihydrocytochalasin B3',4',5',5,7-Pentamethoxyflavone15-MethylheptadecanoylcarnitineThreonyltryptophanProtoanemonin1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine3-MethylnonanedioylcarnitineN-6-Isopent-2-enyl-adenosine2-(4-Methyl-1,3-thiazol-5-yl)ethanol4-Hydroxybenzyl alcoholN-AcetylasparagineVinyl carbamateEicosanoids_12,13diHOME_C18H34O4L-3-Aminodihydro-2(3H)-furanone1-Methyladenosine1-(2-Hydroxyethyl)-2,2,6,6-tetramethyl-4-hydroxypiperidineAvenoleic acidSarcosineProlylvalineMethyl arachidonateHeptanoylcarnitine7,8-Dihydro-D-biopterin16-Hydroxypalmitic acidTaurineZymosterol2'-CMPArachidic acidSpectral Match to Phe-Gln from NIST14PirbuterolSpectral Match to Maltotetraose from NIST14EpigallocatecholDexmethylphenidatePyridoxalTrigonellinebeta-MethylcrotonylglycineN-Acetyl-D-glucosamineCatechol1,10-EpoxygermacroneSpectral Match to Ile-Glu-Lys from NIST14Spectral Match to Val-Ile from NIST14D-gamma-Glutamyl-D-glutamic acidDihydroceramideButenylcarnitine1,2,3,4,Tetrahydro-1,5,7-trimethylnapthalene4-Methylproline2-(4-methoxyphenyl)propan-2-ol(5Z,8R,9S,11R,13E,15S,19R)-9,11,15,19-Tetrahydroxy-5,13-prostadienoic acidgamma-Guanidinobutyric acid4-Ethylaniline(2-{[(2R)-2-hydroxy-3-(pentadecanoyloxy)propyl phosphonato]oxy}ethyl)trimethylazanium7-Methylnonanoylcarnitine4-HydroxymethylpyrazoleN-Hydroxy-1-aminonaphthalene4,6-Cholestadien-3-oneRishitinolNonactinic acidGlycocyaminePhenylalaninePiperonyl butoxide2-(2-amino-3-methylpentanamido)-3-carbamoylpropanoic acidTamoxifenCholesterolCholestenoneL-beta-HomoleucineGentiatibetinePro-leuMorpholineMoluccaninParthenolide6,7-dimethoxyisoquinolyl 4,5-dimethoxy-2-nitrophenyl ketone3-Methoxy-4-hydroxyphenylethanol3-Hydroxy-2H-pyran-2-oneSpectral Match to Lys-Leu from NIST14MyosmineUracilVidarabine2,6-Di-tert-butyl-4-hydroxymethylphenol3-Methylbenzaldehyde(3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dionebeta-D-Glucopyranoside, 2-(hydroxymethyl)phenylCreatine4-Oxo-L-prolineSphingosine 1-phosphate2-HydroxyphenylethanolOctopineSpectral Match to Valerylcarnitine from NIST14Fenpropimorph-carboxybeta-MaltosehydroxydeoxyguanosineMethyl galactoside2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acidPhenylalanyl-Alanine2-(2-amino-3-phenylpropanamido)-3-methylbutanoic acid2-Ethyl-3-hydroxy-2,4,4-trimethyloxazolidineGuanidinosuccinic acidMaltoxazineSimazine3-(2-Hydroxy-3-methoxyphenyl)-2-propenoic acidAcadesineGABAHept-4-enoylcarnitineAdrenic acid(8Z,11Z,13E,15S)-15-hydroxyicosa-8,11,13-trienoic acidBenzothiazoloneDesmosterol3h-TaurineThreoninyl-gamma-glutamate1,3,5-Hexatrienecis-DihydrocarvoneSpectral Match to Ser-Leu from NIST14Glycylmethionine2-Hydroxy-4-imino-2,5-cyclohexadienone2,3-Dihydro-1H-pyrrolizine-5-carboxaldehydeThunberginol APyrrolidine-2-carboxamideDeoxycarnitine(5Z,8Z,11Z)-13-{3-[(2Z)-pent-2-en-1-yl]oxiran-2-yl}trideca-5,8,11-trienoic acid3beta,6beta-Dihydroxynortropane3-Octadec-9-enoyloxy-4-(trimethylazaniumyl)butanoate(9E,12E)-N-(2-Hydroxyethyl)octadeca-9,12-dienamide3-Aminobenzamidetrans-Hexadec-2-enoyl carnitine3-(Hydroxymethyl)furan-2-carbaldehyde4',6-DihydroxyflavoneC9H14N1,2-DimethylimidazoleThreonine, DL-Dihydro-5-methyl-2(3H)-furanoneDimethylethanolamine3-(Octyloxy)propanamine(1S,2R,4aR,8aR)-1-Acetoxy-7-isopropylidene-1,4a-dimethyl-6-oxodecahydro-2-naphthalenyl 2,3-dimethyl-2-oxiranecarboxylateHistidinecis-5-Tetradecenoylcarnitine7Z,10Z-Hexadecadienoic acidTropic acid4-Hydroxy-2H-pyran-3-carboxaldehydeGlutamic acid gamma-methyl esterPhosphoric acid(9E)-Heptadec-9-enoylcarnitine12-Hydroxydodecanoic acidPyridin-2-ol3, 5-TetradecadiencarnitineN-Phenylacetylglutamic acid2-HydroxylauroylcarnitineCysteinylglycineTyrosine methyl esterDiethyl phthalateGlyceryl monopalmitateErgothioneineUndec-3-enoylcarnitineMedrysone(2'E,4'Z,8E)-Colneleic acidQuinoline-4-carboxylic acid(4Z,7Z,10Z,13Z,16Z)-18-(3-ethyloxiran-2-yl)octadeca-4,7,10,13,16-pentaenoic acidHistidiylleucine1-Dodecyl-2-pyrrolidinoneKynurenine2-(2-aminopropanamido)-4-methylpentanoic acid8-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acidN-Acetylhistidine6-Bromoquinolin-2(1H)-one3-(2-(2H,3H-benzo[3,4-e]1,4-dioxin-6-yl)-2-oxoethyl)-3-hydroquinazolin-4-one3-PyridinecarboxaldehydeTryptophanXanthinePolyalanineCholineDodeca-2,4,6-trienoylcarnitineTrp-Pro2-Hexenoylcarnitine2-HydroxyacetamideN-ButylbenzenesulfonamideCapryloyl glycine1H-Imidazole-4-propanol, beta-amino-, (S)-9,11-Octadecadienoic acid, 13-oxo-, (E,Z)-L-Isoleucine6-Oxopiperidine-2-carboxylic acidVitispiraneS-lactoyl-glutathioneTrimethyl glycine2-Aminopurine(6E,9E,12E)-Hexadeca-6,9,12-trienoylcarnitine3-(Tetradecanoylamino)propyl(carboxymethyl)dimethylammoniumPalmitoylcarnitinePhosphorylcholineIMPS-AdenosylhomocysteineTranstorine2,2,6,6-Tetramethylpiperidin-1-olD-LysineFasoracetamDimethyl sulfoxideL-Aspartic acidSpectral Match to .alpha.-L-Glu-L-Tyr from NIST14Unknown (carbon number 9)9-OctadecenamideUridine monophosphateEchimidine N-oxidePhthalic anhydride3-Hydroxybutyrylcarnitine(R)-alpha-Methylhistamine1-Palmitoyl-sn-glycero-3-phosphocholineEthoxyquinN-acetylglucosamine(2-aminoethoxy)[(2R)-2-hydroxy-3-[(9Z)-octadec-9-enoyloxy]propoxy]phosphinic acidAcetyl glutamic acidracemic-Propranolol2-Acetyl-1,5,6,7-tetrahydro-6-hydroxy-7-(hydroxymethyl)-4H-azepine-4-oneCaffeoylcholinePyridoxal phosphateIndole-3-carboxylic acid3-Hydroxy-cis-5-tetradecenoylcarnitinePhosphoric acid, diphenyl ester4-oxo-ButanalGlycyl-L-phenylalaninealpha-MethyltryptamineRiboflavinN-IsovaleroylglycineAlanylnorvalinePalmidrol1-(Aminocarbonyl)-L-prolineTrimethyloxamine19-HydroxydeoxycorticosteroneSemidehydroascorbic acidN-Phenyl-1-naphthylamine7-Oxodehydroepiandrosterone 3-acetateCholestan-3-onem-Aminobenzoic acidBiotinGMPPhenolSpectral Match to Asp-Leu from NIST142-Furanmethanol(2-{[(2R)-2-hydroxy-3-(tetradecanoyloxy)propyl phosphonato]oxy}ethyl)trimethylazanium3-Azetidinecarboxylic acidL-AcetylleucineDicyclohexylamineCinnamic acid4-(2-Furanylmethylene)-3,4-dihydro-2H-pyrroleButyrylcarnitineSpectral Match to 12(S)-Hydroxy-16-heptadecynoic acid from NIST14Aspartyl adenylateSpectral Match to Ser-Phe from NIST144'-HydroxyflavanoneSpectral Match to Monopalmitolein (9c) from NIST14cis-4-Carboxymethylenebut-2-en-4-olide1-Piperidinecarboxaldehyde(2E)-2-Propylpent-2-enoylcarnitineBenzododecinium3-MethylpentanoylcarnitineN(6)-(N-Threonylcarbonyl)adenosineHydroxyindoleacetic acid3-(2-Methylpropyl)pyridine(7E)-5-Hydroxydodec-7-enoylcarnitineIrigenin Trimethyl Ether2-[2-amino-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanoic aciddihydrocorticosteroneIsoferulic acid4',5,6,7-Tetramethoxyflavone9-DecenoylcarnitineOctadeca-9,12-dienal3-Hydroxyisovalerylcarnitine2-(2-amino-3-carbamoylpropanamido)-3-phenylpropanoic acidTiglylcarnitineTridecanoylcarnitineAspartyl-phenylalanine3-HydroxyhexadecanoylcarnitineThiamine ion3-oxo-ButanalGuanosineSpectral Match to 8S-Hydroxy-9E,11Z,14Z-eicosatrienoic acid from NIST14Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11.beta.)-1-acyl-PAFgamma-Glutamylisoleucinebeta-D-GlucosamineMethyl DL-methionate5-Butyl-2-methylpyridineIsoindolin-1-one25-Hydroxycholesterol2-Pyrrolidone1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholineTris(1,3-dichloro-2-propyl)phosphateSpectral Match to Leu-Ile from NIST14Alanylphenylalanine2,6 Dimethylheptanoyl carnitine(2E,6E,8E)-DecatrienoylcarnitineBullatine G4-methylquinoline-2-carboxylic acidUridine4-Amino-2-methylenebutanoic acidAcetyl proline1-Carboxyethylphenylalanine6,10,14-Trimethyl-5,9,13-pentadecatrien-2-one2,2,7,7-Tetramethyl-1,6-dioxaspiro[4.4]nona-3,8-dieneNicotinamide mononucleotideUnknown (carbon number 11)3-acetyl-5-(butan-2-yl)-4-hydroxy-2,5-dihydro-1H-pyrrol-2-one3-hydroxydecanoyl carnitineEquol(1s,4r)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylic acidProline3-Methyl-4-phenyl-3-buten-2-oneTetrahydropyridineMacrosphelide D8-DodecenoylcarnitineIsoindolineSpectral Match to Ile-Leu from NIST14N6-Succinyladenosine5,7-Dihydroxy-4-methylcoumarinCapric dimethyl amine oxideIndole-3-acetic acidTinnevellin glucosideIsovalerylglutamic acidTetradecyldiethanolamine6,15-Diketo-13,14-dihydroprostaglandin F1alphaFumaric acidAcetylcarnitineUric AcidArgininosuccinic acid2-Methylthio-N6-(delta2-isopentenyl)adenosineHypotaurine(2R)-6-methylpiperidine-2-carboxylic acidSucrosePhenylalanylphenylalanineViridicatingamma-GlutamyltyrosineIsoguanosineLPC(22:6)GlycylprolineMmv688888SpermidineTaurocholic acidSpectral Match to Tyr-Val from NIST14PropionylcarnitineDioctyl phthalateOcta-2,6-dienoylcarnitine20-Hydroxy-5,8,11,14-eicosatetraenoic acid3-(Dodecanoylamino)propyl(carboxymethyl)dimethylammonium5-Hydroxy-4-oxo-L-norvaline2H-benzo[d]1,3-dioxolan-5-yl-N-(4,5-dimethyl(1,3-thiazol-2-yl))carboxamideAcetone cyanohydrinGlutamic acidPsicoseSuberic acidHydroxyproline1H-Imidazole-4-carboxamide4-Hexylaniline2-(5-methyl-1,3-dioxobenzo[c]azolin-2-yl)acetic acid5'-MethylthioadenosineHydroxyacetonedelta-ValerobetaineFormamide, N-[(1Z)-2-(4-methoxyphenyl)ethenyl]-CreatinineDexpanthenol3,4,5-trimethoxyphenyl 3,4,5-trimethylpyrazolyl ketoneSerylalanine4-VinylcyclohexenePyridoxic acidPyridoxine1-O-Hexadecyl-sn-glycero-3-phosphocholineDi-N-propylamine7,8-Dimethylalloxazine3-HydroxyhexanoylcarnitineN-acetylgalactosamineN-L-Alanyl-L-valine9-Tetradecenoic acidClupanodonic acidTriethyl phosphate3-Methylene-indolenineCortisolCycloserinePropamocarbHydroxy Tyrosol -Acetatemethyl (7Z)-hexadec-7-enoateUrobilinBetainePivaloylcarnitine(2-aminoethoxy)[(2R)-3-(hexadecanoyloxy)-2-hydroxypropoxy]phosphinic acidMetacetamolCyclopentanone1-Aminocyclopropane-1-carboxylic acid4-({4-[methyl(methylsulfonyl)amino]phenoxy}methyl)hydroquinolin-2-oneCytidineTaurursodiolN-Acetyl-L-aspartic acid(R)-2-Nitro-p-mentha-1,5-diene3-Hydroxytetradeca-6,8,10-trienoylcarnitineBethanidineIndole-3-lactic acid5,6-Dihydroxy-2-methylaminotetralinC17 SphingosineNorethindroneSphinganineGlycerophosphoethanolamineMead acid1-Pyrrolidinecarboxaldehyde7-Ethoxycoumarin1-Methyl-L-tryptophan7-Ketolithocholic acidm-Ethyl_toluene1H-Indene-1,2(3H)-dione(1S,2S,6R,7R,9R)-6-methyl-10,12-dioxatricyclo[7.2.1.0<2,7>]dodec-4-en-8-oneIndole-3-carbaldehydeProgesterone3-EthylpyridineRicinoleic acid, methyl ester6-oxo-ButanalIsohexadecanoic acidCyclopenta[c]pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-[[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]methyl]-, (1S,4aS,7aS)-BistrisSpectral Match to O-Arachidonoylglycidol from NIST14N-CaproylglycineKynurenic acidbeta-AlanineNoradrenalineNorleucine, (+/-)-Prolylisoleucine1,2-BenzoquinonePhenylalanylleucineThiamine monophosphate2-AcetylacteosideMethionineMuramic acidGibberellin A12SinapineIsoleucyl-ArginineStyrene OxideNiacinLauroylcarnitine3-Ethylfuran2-Methyl-2-phenoxypropanoic acidPC(18:1(11Z)/18:2(9Z,12Z))(+/-)-8-hydroxy-5Z,9E,11Z,14Z,17Z-eicosapentaenoic acidSpectral Match to Met-Val from NIST141H-PurineTris(chloroethyl) phosphate(5E,7E)-Dodeca-5,7-dienoylcarnitineSpectral Match to Ile-Pro from NIST14Carnosine8-HETrELauryldiethanolamine3-MethoxytyraminePalmitoyl glycerolN-[1-(4-methoxy-6-oxopyran-2-yl)-2-methylpropyl]acetamideMmv688469(1R,2R,4aS,8aS)-2-[(2R)-2-Hydroxybutyl]-1,3-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-1-naphthalenecarboxylic acid1,2-Dilinolenoyl-sn-glycero-3-phosphatidylcholineN-Fructosyl pyroglutamateNiacinamide1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineSerotonin6-Keto-decanoylcarnitineKojic acid2'-Deoxyguanosine 5'-phosphatePhenylacetylglycine2-(3-amino-6-iminoxanthen-9-yl)benzoic acid, chlorideMethyl sterculate(2E)-HexenedioylcarnitineSpectral Match to Ile-Tyr from NIST141-Octadecanoyl-sn-glycero-3-phosphocholine1,2,3,4-Tetrahydro-beta-carboline-3-carboxylic acidNadide1-Piperideine-2-carboxylic acid1-Phenyl-1-cyclohexene6-Oxopurine5-(4-carboxy-3-methylbutyl)-5,6,8a-trimethyl-3-oxo-4a,6,7,8-tetrahydro-4H-naphthalene-1-carboxylic acidSpectral Match to Leu-Glu from NIST14ErythrocentaurinThreonylleucinePhytosphingosineIsoleucylhydroxyprolineSpectral Match to Glu-Phe from NIST14Spectral Match to 4(5)-EpDPE methyl ester from NIST14TyrosineGallic acid15-Deoxy-delta12,14-prostaglandin J2Glyceryl monooleate5,8,11,14-Eicosatetraenoic acid, ethyl ester5-Methylpyrazine-2-carboxylic AcidLauramine oxideImidazolone4-MethylimidazoleSperminealpha-Eleostearic acid4-carbamoyl-2-acetamidobutanoic acidHypoxanthine9-acetyl-17-hydroxy-10,14-dimethyl-20-oxahexacyclo[11.9.0.0<2,10>.0<4,9>.0<14, 19>.0<19,21>]docosaneHippuric acidLinarinSpectral Match to Val-Phe from NIST14D-Pipecolic acid4-Deoxypyridoxine3-Amino-2,2-dimethylpropanoic acid6,7-Dihydroxy-4-methylcoumarin2-EthylpropanedioylcarnitineSpectral Match to .alpha.-L-Asp-L-Phe from NIST14NegleteinOphthalmic acidN-Acetyl-beta-neuraminic acid4-MethylheptanoylcarnitineAdenineFAD8-MethyltridecanoylcarnitineNicotinuric acidTimonacicInosineSpectral Match to Arachidonoyl amide from NIST14Leu-leu-ome6-Hydroxy-3,4-dihydro-2(1H)-quinolinoneCarbapenemUnknown (carbon number 16)Metolachlor-MorpholinoneDiprotin ACholic acidm-ToluamideArachidonic acidPregnenoloneArachidonoyl-carnitine3-Hydroxy-5,8-tetradecadienoylcarnitineEllagic acidAnserine3-MethylhistidineCaffeine4-Hydroxybenzoylcholine1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholinePC(16:0/22:5(4Z,7Z,10Z,13Z,16Z))ChebiGlyceryl monolinoleategamma-GlutamylcysteineL-MethionineDihydrouracil3-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid8-Methylquinolinealpha-Methylene butyrolactonePro-valDimethyl phthalateTri(2-butoxyethyl) phosphateGlyceryl monomyristateMannitolsn-Glycero-3-phosphocholineGlucose 1-phosphateTri-(2-chloroisopropyl)phosphate(15Z)-tetracos-15-enoylcarnitineOctanoic acid, 2-amino-PolyglutamineSuccinylcarnitineDodecanedioic acid(7R)-7-[(Dodeca-4,7,10-trienoyl)oxy]-4-hydroxy-N,N,N-trimethyl-4-oxo-3,5,9-trioxa-4lambda~5~-phosphapentacosan-1-aminium(3E,5Z)-1,3,5-HeptatrieneDimethyl myristamineIndaneTetradeca-5,7,9-trienoylcarnitineN-LauroylsarcosineDibutyl phthalate4-(2-Aminophenyl)-2,4-dioxobutanoic acid(1R,5R,6R,13R,14R,16S)-6-(3-Furyl)-16-(2-methoxy-2-oxoethyl)-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0~2,11~.0~5,10~]heptadec-10-en-14-yl 2-methylpropanoate3-MethylglutarylcarnitineMethylpyrazineMethylmalonic acid8-Oxo-7,8-dihydrodeoxyguanine2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diolSpectral Match to 13(S)-HODE methyl ester from NIST14Malic acidSpectral Match to Trp-Glu from NIST141-Carboxyethyltyrosine3-ethyl-4-hydroxy-1-benzylhydroquinolin-2-oneOxolinic acidIndole-3-acetaldehydeVitamin K1ErucamideDimethyl-3-hydroxypyrid-4-oneBufalin3-AminopicolinaldehydeOxypurinol2-Benzimidazolecarbamic acidCoronaric acidTraversianalDenudatine3-hydroxyoctanoyl carnitine(8S,9S,10R,11S,13S,14S,17S)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one3-(Indol-3-yl)propionic acid6,11-dioxododecanoic acidMethionine sulfoxideNormetanephrine6,8-Dihydroxypurine1,3-DicyclohexylureaHexadecanamidetrimethyl(2-{[(2R)-3-[(9Z)-octadec-9-enoyloxy]-2-(tetradecanoyloxy)propyl phosphonato]oxy}ethyl)azaniumGly-TyrThreonylphenylalaninep-HydroxybenzaldehydeAzelaic acid2-(2-amino-3-methylpentanamido)-3-hydroxybutanoic acidSpectral Match to Leu-Trp from NIST14Spectral Match to 3-Hydroxyoctadecanoic Acid from NIST14Triphenyl phosphateImidazolepropionic acidEpinephrine2-(Methylsulfonyl)pyridine2-Methyl-1,4-benzoquinone4,5-DimethyloxazoleSM(d18:0/18:1(11Z))5?-CHOLANIC ACID-3?-OL-6_7-DIONESpectral Match to Ile-Met from NIST142-trans,4-cis-Decadienoylcarnitine(1S,5R,9S,13R)-14-formyl-5,9-dimethyltetracyclo[11.2.1.0,?.0?,?]hexadec-14-ene-5-carboxylic acidN,N-Dimethyl-1-tetradecanamine-N-oxideDaidzeinSM(d18:2(4E,14Z)/16:0)3-Hydroxyadipic acid 3,6-lactoneN-epsilon-Acetyllysine(2-{[(2R)-3-(heptadecanoyloxy)-2-hydroxypropyl phosphonato]oxy}ethyl)trimethylazaniumfalseGenetic Ablation of Sfxn5 Induces Mitochondrial Dysfunction and Precipitates Lethal Metabolic Crisis in MiceMitochondrial disorders frequently manifest with life-threatening hepatic metabolic crises. Using a global Sfxn5-knockout mouse model, we investigated the systemic consequences of disrupting this mitochondrial inner-membrane transporter through integrated biochemical, metabolomic, histological, and ultrastructural analyses. Sfxn5 deficiency resulted in complete postnatal lethality accompanied by severe metabolic collapse and progressive multi-organ dysfunction. The liver emerged as the primary site of pathology, exhibiting marked mitochondrial structural damage and widespread disruption of central metabolic pathways, including the tricarboxylic acid cycle, fatty acid β-oxidation, and ammonia detoxification, leading to hyperammonemia and systemic metabolic stress. Importantly, liver-specific reconstitution of Sfxn5 partially restored mitochondrial metabolic function, substantially reduced hyperammonemia, and alleviated multi-organ pathology. Altogether, these findings identify hepatic mitochondrial dysfunction as the central driver of Sfxn5-dependent lethality and establish a critical role for Sfxn5 in maintaining mitochondrial metabolic homeostasis during early postnatal life.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