Metabolite annotation was performed by matching detected features against an in-house metabolite database using mass-to-charge ratio, retention time, and MS/MS spectral information. Metabolite annotation levels followed the Metabolomics Standards Initiative criteria. Additional database mapping and annotation included KEGG COMPOUND, KEGG PATHWAY, HMDB, ChEBI, PubChem, CAS, and related metabolite classification information.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["Chromatographic separation was performed using a Vanquish UHPLC system, Thermo Fisher Scientific, coupled with a Phenomenex Kinetex C18 column, 2.1 mm × 50 mm, 2.6 μm. Mobile phase A was water containing 0.01% acetic acid, and mobile phase B was isopropanol:acetonitrile at 1:1 (v/v). The autosampler temperature was maintained at 4 °C, and the injection volume was 2 μL.
"],"publication":["Multi-omics insights into the woolly trait of Saussurea medusa and coordinated regulation of flavonoid biosynthesis.","Metabolome of four tissues: roots, stems, leaves and flowers of Saussurea medusa."],"submitter_affiliation":["Qinghai University"],"submitter_name":["Guojin Hu"],"organism_part":["root","leaf","flower","stem"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Plant tissue samples were lyophilized and weighed. Approximately 20–25 mg of each sample was mixed with homogenization beads and extraction solution composed of methanol:acetonitrile:water at 2:2:1 (v/v/v), containing isotopically labelled internal standards. The mixture was vortexed for 30 s, homogenized at 35 Hz for 4 min, and sonicated for 5 min in an ice-water bath. The homogenization and sonication steps were repeated three times. Samples were then incubated at -40 °C for 1 h and centrifuged at 12,000 rpm, 4 °C, for 15 min. The supernatant was transferred to sample vials for LC-MS/MS analysis. Quality control samples were prepared by pooling equal aliquots of the supernatant from all experimental samples.
"],"organism":["Saussurea medusa"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS14630"],"author":["Guojin Hu. Qinghai University. 2680427568@qq.com."],"data_transformation_protocol":["Raw LC-MS/MS data were converted to mzXML format using ProteoWizard. Peak detection, extraction, alignment, integration, and downstream processing were performed using an in-house R-based workflow based on XCMS. Data preprocessing included filtering, missing value imputation using the K-nearest neighbor algorithm when appropriate, and normalization using internal standards or total ion current.
"],"study_factor":["Treatment"],"submitter_email":["2680427568@qq.com"],"sample_collection_protocol":["Plant tissue samples (root, stem, leaf, and flower) of Saussurea medusa were collected on August 4, 2023, from the scree zone at Bulunkhanbuda Pass in the Eastern Kunlun Mountains near Lake Arak, Dulan County, Qinghai Province, China (35°41′3″ N, 97°19′13″ E; elevation: 4,914 m).
Four tissue types were sampled from healthy, flowering individuals, with biological replicates included. Immediately following collection, the fresh specimens were flash-frozen in liquid nitrogen to preserve metabolic profiles and stored at -80°C in an ultra-low temperature freezer, with no freeze-thaw cycles prior to non-targeted metabolomic analysis. No additional experimental treatments were performed on the plants before sampling.
"],"omics_type":["Metabolomics"],"study_design":["Orbitrap Exploris 120 mass spectrometer, Thermo Fisher Scientific","Saussurea medusa","Metabolomics","plant tissue","untargeted analysis","Vanquish UHPLC system, Thermo Fisher Scientific","root","leaf","stem","flower","untargeted metabolite profiling"],"curator_keywords":["Orbitrap Exploris 120 mass spectrometer, Thermo Fisher Scientific","Saussurea medusa","Metabolomics","plant tissue","untargeted analysis","Vanquish UHPLC system, Thermo Fisher Scientific","root","leaf","stem","flower","untargeted metabolite profiling"],"mass_spectrometry_protocol":["Mass spectrometry analysis was performed using an Orbitrap Exploris 120 mass spectrometer, Thermo Fisher Scientific. Data were acquired in both positive and negative ion modes using electrospray ionization. The ESI source parameters were as follows: sheath gas flow rate, 50 Arb; auxiliary gas flow rate, 15 Arb; capillary temperature, 320 °C; full MS resolution, 60,000; MS/MS resolution, 15,000; collision energy, SNCE 20/30/40; spray voltage, 3.8 kV in positive ion mode and -3.4 kV in negative ion mode.
"],"metabolite_name":["9-(3,4-Dimethoxyphenyl)-2-methoxy-1H-phenalen-1-one","Tetrahydroharmol","LPC(20:4)","PC(18:3(9Z,12Z,15Z)/18:0)","Corticosterone","Kaempferol 3-O-sophoroside","Acetovanillone","Cassitoroside","3-Hydroxy-b,e-caroten-3'-one","Riboflavin","Ramipril","MeAIB","Apo-10'-violaxanthal","Neantine","2-Methyl-5-(8,11-pentadecadienyl)-1,3-benzenediol","2-Chloromaleylacetate","N1,N10-Dicoumaroylspermidine","Ectoine","(6S,6'S)-epsilon,epsilon-Carotene-3,3'-dione","PC(16:1(9Z)/14:1(9Z))","8-Aminooctanoic acid","Altretamine","PA(20:5(5Z,8Z,11Z,14Z,17Z)/18:4(6Z,9Z,12Z,15Z))","Nipecotic acid","Luteolin 7-O-glucuronide","LPE(18:3)","Scopoletin","Glycolate","Cryptochrome","Kukoamine B","PE(18:3(9Z,12Z,15Z)/16:1(9Z))","Artemidiol","Fluspirilene","PC(20:0/20:3(8Z,11Z,14Z))","Dihydroergotamine","Dehydropipernonaline","Flurazepam","2'',4'',6''-Triacetylglycitin","3-Feruloyl-1,5-quinolactone","Lauric diethanolamide","Lusitanicoside","Arginine","DG(14:0/20:5(5Z,8Z,11Z,14Z,17Z)/0:0)","PE(24:1(15Z)/22:5(7Z,10Z,13Z,16Z,19Z))","Isoalantolactone","Butyrylcarnitine (Car(4:0))","4-Chloromethandienone","Ginkgolide B","Caffeic acid","Rotenone","Fluocinonide","PC(18:0/14:0)","11-alpha-O-beta-D-Glucopyranosyl-16alpha-O-methylneoquassin","3-(2-Furanyl)-2-propenal","2,3-Dihydro-2,3-dihydroxy-4-(4-hydroxyphenyl)-1H-phenalen-1-one","LysoPE(16:1(9Z)/0:0)","Narasin","Cephradine","Oleamide","2-(Methoxymethyl)furan","PE(18:4(6Z,9Z,12Z,15Z)/16:1(9Z))","Hygric acid","Quercetin 3-gentiobioside","1,2-Bis(4-hydroxy-3-methoxyphenyl)ethylene","LysoPC(20:1(11Z))","Isolinderanolide","N1,N5,N10,N14-Tetra-trans-p-coumaroylspermine","Cryptochlorogenic acid","LysoPC(18:1(11Z))","PI(16:1(9Z)/18:1(9Z))","(R)-1-O-[b-D-Glucopyranosyl-(1->6)-b-D-glucopyranoside]-1,3-octanediol","4-Methoxycinnamic acid","2-Methylpiperidine","Canthaxanthin","PE(20:5(5Z,8Z,11Z,14Z,17Z)/18:4(6Z,9Z,12Z,15Z))","PC(20:2(11Z,14Z)/18:3(9Z,12Z,15Z))","Mono(2-ethylhexyl) phthalate","Biliverdin","trans-Zeatin","PC(14:1(9Z)/P-16:0)","PC(20:3(5Z,8Z,11Z)/20:1(11Z))","Fumonisin B1","L-Thyronine","6-Hydroxyluteolin 7-glucoside","DG(16:0/18:4(6Z,9Z,12Z,15Z)/0:0)","3-Glucosyl-2,3',4,4',6-pentahydroxybenzophenone","Moracetin","Capsiate","Rutaecarpine","Pyridoxine 5-phosphate","(3beta,5alpha,6beta,22E,24R)-23-Methylergosta-7,22-diene-3,5,6-triol","8,11-Heptadecadienal","Stigmasterol","2-Hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one","Thamnosin","4'-Hydroxy-3'-methylacetophenone","Tagatose","Itraconazole","PC(16:0/18:1(9Z))","PC(18:1(9E)/18:1(9E))","Etoposide","PC(20:2(11Z,14Z)/15:0)","N-Acetyl-6-O-L-fucosyl-D-glucosamine","Allose","Hirsutin","Occidentoside","N1,N10-Diferuloylspermidine","Matairesinol","Arachidonate","PC(18:0/18:1(9Z))","Glucoiberin","DG(20:3(8Z,11Z,14Z)/14:1(9Z)/0:0)","Candesartan","Alverine","Daltogen","trans-3-Octen-2-ol","Isoeugenitin","Glucose","N-Jasmonoylisoleucine","LPE(16:0)","Zanamivir","Chromone","PC(16:0/16:0)","Cortexolone","Sphingosine","Carbendazim","CPA(18:2(9Z,12Z)/0:0)","4-Hydroxy-17beta-estradiol","PA(22:2(13Z,16Z)/15:0)","5-Methyl-3-thiophenethiol","Hydroxygaleon","Buprenorphine","MG(18:4(6Z,9Z,12Z,15Z)/0:0/0:0)","Geranylgeranylcysteine","Trehalose","Cheirotoxol","Umbelliferone","Convalloside","Demethoxyshogaol","PE(20:2(11Z,14Z)/14:1(9Z))","[10]-Gingerdione","5'-Methylthioadenosine","Herculin","Tetrahydropteroyltri-L-glutamate","DEHP","Thiocysteine","Acetophenone","2,5-Dimethyl-3-(methylthio)furan","4-Butyloxazole","Piperolactam A","2-Ethylbutanal","4-(Butoxymethyl)-2-methoxyphenol","PC(15:0/22:2(13Z,16Z))","3-Oxo-OPC6-CoA","4-Deoxycohumulone","5-Aminopentanoic acid","PC(18:3(6Z,9Z,12Z)/14:1(9Z))","Ssioriside","Docosanamide","Verbascoside","Bilobalide A","Thiabendazole","Sterol","Auberganol","4-Acetyl-6-tert-butyl-1,1-dimethylindane","Tubocurarine","Steviol","Pregabalin","Valnoctamide","Pipecolic acid","Ranolazine","Ganciclovir","Betaine","Formylfusarochromanone","Ketazolam","Sakuranetin","8-Hydroxynevirapine","Entinostat","Homoharringtonine","Pioglitazone","D-Galactopyranosyl-(1->3)-D-galactopyranosyl-(1->3)-L-arabinose","PC(18:1(9Z)/18:3(9Z,12Z,15Z))","Aurochrome","Rosifoliol","N1,N5,N10-Tris-trans-p-coumaroylspermine","Candoxatril","Monobutyl phthalate","LPC(16:0)","Cohumulone","6''-Malonylcosmosiin","Thiazopyr","Viniferal","N-Hexadecanoylpyrrolidine","PC(18:1(9Z)/18:1(9Z))","Isobutyrylcarnitine (Car(4:0))","Palmitamide","Protoanemonin","Labadoside","Sphinganine","LPC(17:0/0:0)","Citrusinol","Ziritaxestat","2',4',6'-Trihydroxyacetophenone","12-Methyl-13-tridecanolide","Prostaglandin J2","PC(18:3(9Z,12Z,15Z)/15:0)","Piperalol","Capsorubin","Trolox","3-Caffeoyl-1,5-quinolactone","Maltol","3,5,5-Trimethylhexanal","Galactose","Valpromide","Xanthohumol","beta-Doradecin","Iraldeine","11beta-hydroxyandrost-4-ene-3,17-dione","3-(5,6,6-Trimethylbicyclo[2.2.1]hept-1-yl)cyclohexanol","3-Methoxy-4,5-methylenedioxycinnamaldehyde","DG(18:4(6Z,9Z,12Z,15Z)/18:4(6Z,9Z,12Z,15Z)/0:0)","Heteroxanthin","Hexamethylene bisacetamide","Taxifolin","Argenteane","Arctigenin","Trigonelline","Succinate","Tiotropium","Bezafibrate","PE(18:3(9Z,12Z,15Z)/18:1(9Z))","Sultopride hydrochloride","PC(37:5)","Kaempferol 3-O-gentiobioside","Gabapentin","Imiquimod","Linaprazan","Citrinin","D-erythro-Eritadenine","Rhoifolin","Spironolactone","Linoleamide","1-Heptadecene-4,6-diyne-3,9-diol","Paclitaxel","Obtusifolin","Hexamethylquercetagetin","Phenylalanine","Kaempferol","Succinylcholine","Kojic acid","Tamoxifen","Capsorubinidione","Testosterone","2,6-Cyclolycopene-1,5-diol","PE(18:4(6Z,9Z,12Z,15Z)/16:0)","Pipericine","PC(18:2(9Z,12Z)/14:1(9Z))","LysoPE(18:1(11Z)/0:0)","PS(16:0/15:0)","Dihydro-4-mercapto-3(2H)-furanone","Tyrosine","Steviobioside","beta1-Tomatidine","Dihydro-O-methylsterigmatocystin","2,3-Dehydrokievitol","3-Amino-3-(4-hydroxyphenyl)propanoic acid","2-Methyl-1-hydroxypropyl-ThPP","DG(16:0/16:0/0:0)","Cyclophosphamide","N6-Carbamoyl-L-threonyladenosine","Mascaroside","NAE(18:1)","N-[[3-Hydroxy-2-(2-pentenyl)cyclopentyl]acetyl]isoleucine","Eujambolin","Lutein 5,6-epoxide","Nevirapine","Chloroquine","Patamostat","Diosmin","Rescinnamine","PE(22:0/20:4(8Z,11Z,14Z,17Z))","LPC(18:0/0:0)","Ramontoside","3,3',4,4'-Tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl","Adenine","Chlorogenic acid","DG(18:4(6Z,9Z,12Z,15Z)/16:0/0:0)","PA(20:5(5Z,8Z,11Z,14Z,17Z)/18:3(6Z,9Z,12Z))","7-Aminomethyl-7-carbaguanine","Fructose","PC(20:5(5Z,8Z,11Z,14Z,17Z)/20:2(11Z,14Z))","Cocaine","Curlone","Pyridaben","Lumichrome","Glutamine","Poly-g-D-glutamate","Levonordefrin","2,6-Di-tert-butyl-4-ethylphenol","Gartanin","Ouabain","Cortolone","LPC(18:2/0:0)","5,6-Dihydro-11-methoxyyangonin","Melibiose","Sambacin","Dieporeticenin","Halazepam","Homoeriodictyol","Stearamide","4,5-Dicaffeoylquinic acid","Galactosamine","Tyramine","Lonicerin","PE(14:0/22:5(7Z,10Z,13Z,16Z,19Z))","(2S,2''S,3S,3''R,4S)-3,4',5,7-Tetrahydroxyflavan(2->7,4->8)-3,4',5,7-tetrahydroxyflavan","Neoliquiritin","PC(20:1(11Z)/18:3(9Z,12Z,15Z))","Maltotriose","7alpha-Hydroxyandrostenedione","Quercetin","Avocadienofuran","(±)-Dihydroactinidiolide","Glycerophosphocholine","PC(20:0/20:2(11Z,14Z))","4-Hydroxy-3-methoxy-2,10-bisaboladien-9-one","Ribose-1-arsenate","Olitoriusin","PC(18:4(6Z,9Z,12Z,15Z)/14:1(9Z))","Castamollissin","2-Hydroxy-4-methylbenzaldehyde","Dimethyl phthalate","PC(34:3)","Sorbose","Astragalin","3-Pyridylacetic acid","Perphenazine","Ifenprodil (tartrate)","alpha-L-Rhamnopyranosyl-(1->3)-alpha-D-galactopyranosyl-(1->3)-L-fucose","Ginsenoside F5","PA(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:4(6Z,9Z,12Z,15Z))","Pentosidine","Dimethyl adipate","PC(16:0/20:4)","(3b,6b,8a,12a)-8,12-Epoxy-7(11)-eremophilene-6,8,12-trimethoxy-3-ol","Prephytoene diphosphate","Fluorometholone","3-cis-Hydroxy-b,e-Caroten-3'-one","Xanthophyll","Sph(t18:0)","PE(18:4(6Z,9Z,12Z,15Z)/P-16:0)","Diosmetin","PA(20:0/20:1(11Z))","Adenosine monophosphate (AMP)","(E)-Squamosamide","Proscillaridin A","Betulin","Cocaethylene","o-Tyrosine","PC(15:0/22:4(7Z,10Z,13Z,16Z))","2-Aminopurine","Italipyrone","Eupatorin","Erucamide","LysoPC(22:2(13Z,16Z))","Idoxanthin","1-(1-Pyrrolidinyl)-2-propanone","Triricinolein","Alloxanthin","Eplerenone","(3alphaOH,20S,24S)-3,19:20,24-Diepoxydammarane-3,25-diol","Kaempferol 3-neohesperidoside","Yangonin","alpha-Cyperone","2-Piperidone","(3S,3'S,5R,5'R,6R)-3,6-Epoxy-5,6-dihydro-3',5,8'-trihydroxy-beta,kappa-caroten-6'-one","Normetanephrine","PE(18:3(9Z,12Z,15Z)/P-16:0)","Rolitetracycline","1,3-Dicyclohexylurea","PA(18:4(6Z,9Z,12Z,15Z)/18:2(9Z,12Z))","beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-beta-D-glucopyranosyl-(1->6)-D-mannose","LysoPC(22:1(13Z))","Raffinose","Cis-zeatin-9-N-glucoside","PE(20:5(5Z,8Z,11Z,14Z,17Z)/14:0)","Piperidine","Baicalin","Prexanthoperol","Moguisteine","Ziprasidone","Rutin","PC(20:1(11Z)/15:0)","Irinotecan","Chlorcyclizine","LysoPC(20:2(11Z,14Z))","PC(20:1(11Z)/18:1(11Z))","Norbuprenorphine","Daidzein","Enzastaurin"],"additional_accession":[]},"is_claimable":false,"name":"Metabolome of four tissues: roots, stems, leaves and flowers of Saussurea medusa","description":"Metabolomics identified 1,792 metabolites, including 18 bioactive metabolites with tissue-specific accumulation, most of which are flavonoids. Integrated metabolomics and transcriptomics analysis further revealed 27 flavonoid biosynthetic genes highly expressed in flowers and leaves, correlating strongly with accumulation of flavonoids, indicating coordinated regulation of secondary metabolism.","dates":{"publication":"2026-05-30","submission":"2026-05-30"},"accession":"MTBLS14630","cross_references":{"HMDB":["HMDB:HMDB0001901; KEGG:C02378","HMDB:HMDB0000482; KEGG:C06423","HMDB:HMDB0000689; KEGG:C21399","HMDB:HMDB0001877; KEGG:C07185","HMDB:HMDB0000888","HMDB:HMDB0001870; KEGG:C00180","HMDB:HMDB0003411; KEGG:C16435","HMDB:HMDB0000535; KEGG:C01585","HMDB:HMDB0002388","HMDB:HMDB0247617; KEGG:C19418","HMDB:HMDB0029737; KEGG:C08493","HMDB:HMDB0000318; KEGG:C05576","HMDB:HMDB0014607","HMDB:HMDB0000847; KEGG:C01601","HMDB:HMDB0002428; KEGG:C06337","HMDB:HMDB0062121","HMDB:HMDB0000271; KEGG:C00213","HMDB:HMDB0000161; KEGG:C00041","HMDB:HMDB0030979","HMDB:HMDB0003073; KEGG:C06426","HMDB:HMDB0002596","HMDB:HMDB0000933; KEGG:C16308","HMDB:HMDB0000792; KEGG:C08277","HMDB:HMDB0244269","HMDB:HMDB0000893; KEGG:C08278","HMDB:HMDB0000434","HMDB:HMDB0001388; KEGG:C06427","HMDB:HMDB0002430","HMDB:HMDB0004669; KEGG:C14766","HMDB:HMDB0000511; KEGG:C01571","HMDB:HMDB0141782; KEGG:C02666","HMDB:HMDB0000954; KEGG:C01494","HMDB:HMDB0000703; KEGG:C01984","HMDB:HMDB0000094; KEGG:C00158","HMDB:HMDB0012710; KEGG:C00944","HMDB:HMDB0000148; KEGG:C00025","HMDB:HMDB0000168; KEGG:C00152","HMDB:HMDB0033923; KEGG:C16434","HMDB:HMDB0253298","HMDB:HMDB0000801; KEGG:C01607","HMDB:HMDB0035214; KEGG:C10343","HMDB:HMDB0000784; KEGG:C08261","HMDB:HMDB0001044; KEGG:C00362","HMDB:HMDB0001401; KEGG:C00092","HMDB:HMDB0062620; KEGG:C01620","HMDB:HMDB0006330; KEGG:C00636","HMDB:HMDB0003971; KEGG:C05345","HMDB:HMDB0006800; KEGG:C03267","HMDB:HMDB0000947; KEGG:C17715","HMDB:HMDB0000857; KEGG:C02656","HMDB:HMDB0000691; KEGG:C00383","HMDB:HMDB0003072; KEGG:C00296","HMDB:HMDB0011733; KEGG:C02037","HMDB:HMDB0001078; KEGG:C00275","HMDB:HMDB0062549; KEGG:C03045","HMDB:HMDB0038925","HMDB:HMDB0242525; KEGG:C01533","HMDB:HMDB0000755; KEGG:C03672","HMDB:HMDB0062203; KEGG:C00123","HMDB:HMDB0002068; KEGG:C08316","HMDB:HMDB0002059; KEGG:C08317","HMDB:HMDB0001895; KEGG:C00805","HMDB:HMDB0002641; KEGG:C01772","HMDB:HMDB0014389","HMDB:HMDB0001900; KEGG:C01114","HMDB:HMDB0001076; KEGG:C01094","HMDB:HMDB0002466; KEGG:C00587","HMDB:HMDB0006547; KEGG:C16300","HMDB:HMDB0000782","HMDB:HMDB0000426; KEGG:C00815","HMDB:HMDB0000126; KEGG:C00093","HMDB:HMDB0000744; KEGG:C00149","HMDB:HMDB0251526; KEGG:C01933","HMDB:HMDB0000555","HMDB:HMDB0061706","HMDB:HMDB0000126; KEGG:C00623","HMDB:HMDB0000484; KEGG:C06672","HMDB:HMDB0000638; KEGG:C02679","HMDB:HMDB0035106","HMDB:HMDB0301803; KEGG:C04785","HMDB:HMDB0002124; KEGG:C01477","HMDB:HMDB0302426","HMDB:HMDB0000694; KEGG:C03196","HMDB:HMDB0245742","HMDB:HMDB0034219; KEGG:C03844","HMDB:HMDB0000500; KEGG:C00156","HMDB:HMDB0002203","HMDB:HMDB0000068; KEGG:C00788","HMDB:HMDB0000020; KEGG:C00642","HMDB:HMDB0303562; KEGG:C20462","HMDB:HMDB0011506","HMDB:HMDB0012535; KEGG:C20388","HMDB:HMDB0005800; KEGG:C01514","HMDB:HMDB0000512; KEGG:C03519","HMDB:HMDB0013070; KEGG:C02325","HMDB:HMDB0062660; KEGG:C01046","HMDB:HMDB0000849; KEGG:C00507","HMDB:HMDB0000423; KEGG:C10447","HMDB:HMDB0001139; KEGG:C00639","HMDB:HMDB0003229; KEGG:C08362","HMDB:HMDB0000296; KEGG:C00299","HMDB:HMDB0002368; KEGG:C08323","HMDB:HMDB0010378; KEGG:C21938","HMDB:HMDB0000673; KEGG:C01595","HMDB:HMDB0000806; KEGG:C06424","HMDB:HMDB0000355; KEGG:C03761","HMDB:HMDB0011730; KEGG:C08243","HMDB:HMDB0003070; KEGG:C00493","HMDB:HMDB0032613","HMDB:HMDB0012308; KEGG:C00755","HMDB:HMDB0000026; KEGG:C02642","HMDB:HMDB0000826; KEGG:C16537","HMDB:HMDB0004236; KEGG:C05954","HMDB:HMDB0011718; KEGG:C00633","HMDB:HMDB0000133; KEGG:C00387","HMDB:HMDB0031072","HMDB:HMDB0247628","HMDB:HMDB0031057","HMDB:HMDB0245808","HMDB:HMDB0002925; KEGG:C03242","HMDB:HMDB0030821; KEGG:C09206","HMDB:HMDB0000207; KEGG:C00712","HMDB:HMDB0000005; KEGG:C00109","HMDB:HMDB0000321; KEGG:C02360","HMDB:HMDB0030820; KEGG:C09264","HMDB:HMDB0003231; KEGG:C08367","HMDB:HMDB0005060; KEGG:C16525","HMDB:HMDB0000220; KEGG:C00249","HMDB:HMDB0245492","HMDB:HMDB0304941; KEGG:C12115","HMDB:HMDB0012453; KEGG:C17333","HMDB:HMDB0240266","HMDB:HMDB0258653","HMDB:HMDB0002231; KEGG:C16526","HMDB:HMDB0034296","HMDB:HMDB0002003; KEGG:C08320","HMDB:HMDB0033139","HMDB:HMDB0000955; KEGG:C10470","HMDB:HMDB0000639; KEGG:C00879","HMDB:HMDB0303913","HMDB:HMDB0000669; KEGG:C05852","HMDB:HMDB0001713; KEGG:C12621","HMDB:HMDB0000827; KEGG:C01530","HMDB:HMDB0002259","HMDB:HMDB0004667; KEGG:C14762","HMDB:HMDB0029645; KEGG:C10726","HMDB:HMDB0006294; KEGG:C18218","HMDB:HMDB0000623; KEGG:C02678","HMDB:HMDB0002035; KEGG:C00811","HMDB:HMDB0000360","HMDB:HMDB0038720","HMDB:HMDB0000672; KEGG:C19615","HMDB:HMDB0003540; KEGG:C01367","HMDB:HMDB0251621","HMDB:HMDB0000176; KEGG:C01384","HMDB:HMDB0000286; KEGG:C00029","HMDB:HMDB0000302; KEGG:C00052","HMDB:HMDB0040254","HMDB:HMDB0254198; KEGG:C03212","HMDB:HMDB0032594; KEGG:C10804","HMDB:HMDB0001868","HMDB:HMDB0015130","HMDB:HMDB0000157; KEGG:C00262","HMDB:HMDB0000085; KEGG:C00330","HMDB:HMDB0244307","HMDB:HMDB0039176","HMDB:HMDB0005032; KEGG:C07778","HMDB:HMDB0015267; KEGG:C06875","HMDB:HMDB0001991; KEGG:C16353","HMDB:HMDB0014581","HMDB:HMDB0001366; KEGG:C15587","HMDB:HMDB0004029; KEGG:C05490","HMDB:HMDB0001855","HMDB:HMDB0253195","HMDB:HMDB0259582","HMDB:HMDB0060676; KEGG:C07493","HMDB:HMDB0033751; KEGG:C01750","HMDB:HMDB0014118","HMDB:HMDB0032048","HMDB:HMDB0002776; KEGG:C04671","HMDB:HMDB0029852","HMDB:HMDB0031557","HMDB:HMDB0039353","HMDB:HMDB0251767; KEGG:C10342","HMDB:HMDB0030095","HMDB:HMDB0002655; KEGG:C10084","HMDB:HMDB0030775; KEGG:C10073","HMDB:HMDB0031654","HMDB:HMDB0030524; KEGG:C14437","HMDB:HMDB0033801","HMDB:HMDB0007853; KEGG:C04036","HMDB:HMDB0029681","HMDB:HMDB0038482","HMDB:HMDB0000072; KEGG:C00417","HMDB:HMDB0008928","HMDB:HMDB0000354","HMDB:HMDB0000428","HMDB:HMDB0035635","HMDB:HMDB0002074","HMDB:HMDB0036105","HMDB:HMDB0249749","HMDB:HMDB0014452","HMDB:HMDB0002755; KEGG:C10107","HMDB:HMDB0002318","HMDB:HMDB0014775; KEGG:C06832","HMDB:HMDB0029514","HMDB:HMDB0038905","HMDB:HMDB0033799","HMDB:HMDB0247732; KEGG:C01349","HMDB:HMDB0140989","HMDB:HMDB0029689","HMDB:HMDB0301809; KEGG:C16915","HMDB:HMDB0036633; KEGG:C10186","HMDB:HMDB0032622","HMDB:HMDB0029481","HMDB:HMDB0032876; KEGG:C10401","HMDB:HMDB0014438; KEGG:C11372","HMDB:HMDB0014681; KEGG:C07204","HMDB:HMDB0003265; KEGG:C09755","HMDB:HMDB0040838","HMDB:HMDB0041149","HMDB:HMDB0032573","HMDB:HMDB0034843; KEGG:C10501","HMDB:HMDB0014490","HMDB:HMDB0030447","HMDB:HMDB0034733","HMDB:HMDB0014602","HMDB:HMDB0014733; KEGG:C06624","HMDB:HMDB0014710; KEGG:C07201","HMDB:HMDB0033987; KEGG:C10509","HMDB:HMDB0014844; KEGG:C07124","HMDB:HMDB0000258; KEGG:C00089","HMDB:HMDB0001847; KEGG:C07481","HMDB:HMDB0000215; KEGG:C00140","HMDB:HMDB0001198; KEGG:C02166","HMDB:HMDB0029379; KEGG:C00933","HMDB:HMDB0011503","HMDB:HMDB0249243; KEGG:C03690","HMDB:HMDB0010382","HMDB:HMDB0003249; KEGG:C05625","HMDB:HMDB0254199; KEGG:C01727","HMDB:HMDB0000086; KEGG:C00670","HMDB:HMDB0000517; KEGG:C00062","HMDB:HMDB0012273","HMDB:HMDB0032358","HMDB:HMDB0244166","HMDB:HMDB0032538; KEGG:C06771","HMDB:HMDB0000043; KEGG:C00719","HMDB:HMDB0010384","HMDB:HMDB0000306; KEGG:C00483","HMDB:HMDB0240541; KEGG:C03515","HMDB:HMDB0035240","HMDB:HMDB0000593","HMDB:HMDB0003164; KEGG:C00852","HMDB:HMDB0000244; KEGG:C00255","HMDB:HMDB0001262; KEGG:C01835","HMDB:HMDB0000716; KEGG:C00408","HMDB:HMDB0000641; KEGG:C00064","HMDB:HMDB0010386; KEGG:C04100","HMDB:HMDB0001173; KEGG:C00170","HMDB:HMDB0244507","HMDB:HMDB0003831; KEGG:C04368","HMDB:HMDB0000975; KEGG:C01083","HMDB:HMDB0034146; KEGG:C13846","HMDB:HMDB0005801; KEGG:C05903","HMDB:HMDB0041832","HMDB:HMDB0000048; KEGG:C05402","HMDB:HMDB0304696; KEGG:C12634","HMDB:HMDB0015652; KEGG:C11768","HMDB:HMDB0013248; KEGG:C03343","HMDB:HMDB0247918; KEGG:C11380","HMDB:HMDB0001538","HMDB:HMDB0029865; KEGG:C09315","HMDB:HMDB0000158; KEGG:C00082","HMDB:HMDB0303606","HMDB:HMDB0004610; KEGG:C12144","HMDB:HMDB0030707","HMDB:HMDB0007982","HMDB:HMDB0007972; KEGG:C13875","HMDB:HMDB0000875; KEGG:C01004","HMDB:HMDB0000819; KEGG:C05589","HMDB:HMDB0038848","HMDB:HMDB0259753","HMDB:HMDB0246950; KEGG:C00247","HMDB:HMDB0003345; KEGG:C00267","HMDB:HMDB0030653","HMDB:HMDB0003418; KEGG:C00795","HMDB:HMDB0001151; KEGG:C01487","HMDB:HMDB0005799; KEGG:C12630","HMDB:HMDB0000034; KEGG:C00147","HMDB:HMDB0259756","HMDB:HMDB0000143; KEGG:C00984","HMDB:HMDB0000660; KEGG:C02336","HMDB:HMDB0037573","HMDB:HMDB0252755","HMDB:HMDB0059824","HMDB:HMDB0000045; KEGG:C00020","HMDB:HMDB0000159; KEGG:C00079","HMDB:HMDB0012108","HMDB:HMDB0258623; KEGG:C11708","HMDB:HMDB0029644","HMDB:HMDB0003355; KEGG:C00431","HMDB:HMDB0094696","HMDB:HMDB0245025","HMDB:HMDB0013247","HMDB:HMDB0005896; KEGG:C14209","HMDB:HMDB0002013; KEGG:C02862","HMDB:HMDB0000736","HMDB:HMDB0000234; KEGG:C00535","HMDB:HMDB0011749","HMDB:HMDB0002141","HMDB:HMDB0003501; KEGG:C01197","HMDB:HMDB0251828","HMDB:HMDB0251388; KEGG:C11233","HMDB:HMDB0094660; KEGG:C14175","HMDB:HMDB0301692","HMDB:HMDB0003213; KEGG:C00492","HMDB:HMDB0000252; KEGG:C00319","HMDB:HMDB0002088; KEGG:C20792","HMDB:HMDB0062656","HMDB:HMDB0255618","HMDB:HMDB0014838; KEGG:C12512","HMDB:HMDB0256851","HMDB:HMDB0014383; KEGG:C07263","HMDB:HMDB0006050","HMDB:HMDB0008031","HMDB:HMDB0000564; KEGG:D03585","HMDB:HMDB0059883; KEGG:C12286","HMDB:HMDB0002040","HMDB:HMDB0256141","HMDB:HMDB0038804","HMDB:HMDB0015264; KEGG:C07675","HMDB:HMDB0000015; KEGG:C05488","HMDB:HMDB0006771; KEGG:C05296","HMDB:HMDB0014631","HMDB:HMDB0014388","HMDB:HMDB0001547; KEGG:C02140","HMDB:HMDB0006773; KEGG:C05284","HMDB:HMDB0002710; KEGG:C05957","HMDB:HMDB0253384","HMDB:HMDB0001319; KEGG:C00627","HMDB:HMDB0254096","HMDB:HMDB0253205; KEGG:C09756","HMDB:HMDB0037061","HMDB:HMDB0041857","HMDB:HMDB0032848","HMDB:HMDB0034301; KEGG:C01746","HMDB:HMDB0030926","HMDB:HMDB0014347; KEGG:C07546","HMDB:HMDB0003933","HMDB:HMDB0032847; KEGG:C04547","HMDB:HMDB0034144; KEGG:C09980","HMDB:HMDB0039652","HMDB:HMDB0031073","HMDB:HMDB0007881","HMDB:HMDB0032416","HMDB:HMDB0032740","HMDB:HMDB0040970","HMDB:HMDB0029475","HMDB:HMDB0034780; KEGG:C20203","HMDB:HMDB0037068","HMDB:HMDB0014565; KEGG:C07310","HMDB:HMDB0037429; KEGG:C12249","HMDB:HMDB0030776; KEGG:C11918","HMDB:HMDB0032938","HMDB:HMDB0032603","HMDB:HMDB0014375","HMDB:HMDB0040030","HMDB:HMDB0031220","HMDB:HMDB0031867","HMDB:HMDB0000583","HMDB:HMDB0060525; KEGG:C17616","HMDB:HMDB0029676; KEGG:C10038","HMDB:HMDB0035303","HMDB:HMDB0033910; KEGG:C07113","HMDB:HMDB0003448","HMDB:HMDB0037424","HMDB:HMDB0036707","HMDB:HMDB0036861; KEGG:C07602","HMDB:HMDB0030648","HMDB:HMDB0247418","HMDB:HMDB0007098; KEGG:C00165","HMDB:HMDB0032450","HMDB:HMDB0040179","HMDB:HMDB0015224; KEGG:C01443","HMDB:HMDB0036735","HMDB:HMDB0038782","HMDB:HMDB0001008; KEGG:C00500","HMDB:HMDB0035934; KEGG:C09484","HMDB:HMDB0034247","HMDB:HMDB0035789","HMDB:HMDB0008038","HMDB:HMDB0011508","HMDB:HMDB0000937; KEGG:C05442","HMDB:HMDB0031839","HMDB:HMDB0035767","HMDB:HMDB0041606","HMDB:HMDB0014862","HMDB:HMDB0032923; KEGG:C14516","HMDB:HMDB0036706","HMDB:HMDB0042010; KEGG:C09238","HMDB:HMDB0036873","HMDB:HMDB0014391; KEGG:C07568","HMDB:HMDB0014911; KEGG:C01576","HMDB:HMDB0014988; KEGG:C07427","HMDB:HMDB0015479","HMDB:HMDB0252128","HMDB:HMDB0039963","HMDB:HMDB0038970","HMDB:HMDB0000667","HMDB:HMDB0037490","HMDB:HMDB0012202","HMDB:HMDB0007956","HMDB:HMDB0041901","HMDB:HMDB0036623","HMDB:HMDB0039613","HMDB:HMDB0032645","HMDB:HMDB0030574","HMDB:HMDB0014672; KEGG:C07888","HMDB:HMDB0003128; KEGG:C05481","HMDB:HMDB0005015","HMDB:HMDB0039143","HMDB:HMDB0034712","HMDB:HMDB0034694","HMDB:HMDB0033981","HMDB:HMDB0038900","HMDB:HMDB0029289","HMDB:HMDB0003312; KEGG:C10208","HMDB:HMDB0007330","HMDB:HMDB0030550","HMDB:HMDB0015465","HMDB:HMDB0029287","HMDB:HMDB0039715","HMDB:HMDB0029792","HMDB:HMDB0012204; KEGG:C00371","HMDB:HMDB0255882; KEGG:C17039","HMDB:HMDB0060546","HMDB:HMDB0010385; KEGG:C04230","HMDB:HMDB0036877","HMDB:HMDB0036874","HMDB:HMDB0011571","HMDB:HMDB0008278; KEGG:C00157","HMDB:HMDB0008374; KEGG:C00157","HMDB:HMDB0010392; KEGG:C04230","HMDB:HMDB0007027","HMDB:HMDB0035868","HMDB:HMDB0039454","HMDB:HMDB0037970","HMDB:HMDB0008201; KEGG:C00157","HMDB:HMDB0010399; KEGG:C04230","HMDB:HMDB0007106","HMDB:HMDB0037795","HMDB:HMDB0015311; KEGG:C06540","HMDB:HMDB0011690; KEGG:C16675","HMDB:HMDB0001514; KEGG:C02262","HMDB:HMDB0038105","HMDB:HMDB0251832","HMDB:HMDB0035603; KEGG:C09132","HMDB:HMDB0015298","HMDB:HMDB0006866; KEGG:C15976","HMDB:HMDB0029308","HMDB:HMDB0031851","HMDB:HMDB0007473","HMDB:HMDB14284","HMDB:HMDB0008107; KEGG:C00157","HMDB:HMDB0037642","HMDB:HMDB0015526","HMDB:HMDB0038288","HMDB:HMDB0008338; KEGG:C00157","HMDB:HMDB0008164; KEGG:C00157","HMDB:HMDB0036397","HMDB:HMDB0034344; KEGG:C01752","HMDB:HMDB0029835","HMDB:HMDB0010391; KEGG:C04230","HMDB:HMDB0008330; KEGG:C00157","HMDB:HMDB0008131; KEGG:C00157","HMDB:HMDB0031678","HMDB:HMDB0039773","HMDB:HMDB0029391","HMDB:HMDB0041623","HMDB:HMDB0008301; KEGG:C00157","HMDB:HMDB0010395","HMDB:HMDB0036838","HMDB:HMDB0007999; KEGG:C00157","HMDB:HMDB0115076","HMDB:HMDB0034436; KEGG:C07593","HMDB:HMDB0008305; KEGG:C00157","HMDB:HMDB0038061","HMDB:HMDB0041248","HMDB:HMDB0259785","HMDB:HMDB0007954; KEGG:C00157","HMDB:HMDB0031730","HMDB:HMDB0034120; KEGG:C10474","HMDB:HMDB0007955; KEGG:C00157","HMDB:HMDB0008276; KEGG:C00157","HMDB:HMDB0008198; KEGG:C00157","HMDB:HMDB0037479; KEGG:C16417","HMDB:HMDB0033917","HMDB:HMDB0037346","HMDB:HMDB0039962","HMDB:HMDB0008297; KEGG:C00157","HMDB:HMDB0033422","HMDB:HMDB0031963","HMDB:HMDB0033469","HMDB:HMDB0040811","HMDB:HMDB0031769; KEGG:C10897","HMDB:HMDB0038888","HMDB:HMDB0008230; KEGG:C00157","HMDB:HMDB0038722","HMDB:HMDB0014754","HMDB:HMDB0015043; KEGG:C01416","HMDB:HMDB0115035","HMDB:HMDB0256960; KEGG:C18614","HMDB:HMDB0007928; KEGG:C00157","HMDB:HMDB0041250","HMDB:HMDB0039091","HMDB:HMDB0014828","HMDB:HMDB0041307","HMDB:HMDB0029473","HMDB:HMDB0040656","HMDB:HMDB0031535","HMDB:HMDB0041289","HMDB:HMDB0060347","HMDB:HMDB0008506; KEGG:C00157","HMDB:HMDB0029857","HMDB:HMDB0030591","HMDB:HMDB0033633","HMDB:HMDB0002890","HMDB:HMDB0036924","HMDB:HMDB0015414","HMDB:HMDB0030700; KEGG:C10063","HMDB:HMDB0038929","HMDB:HMDB0015181; KEGG:C07007","HMDB:HMDB0039018","HMDB:HMDB0240650; KEGG:C06231","HMDB:HMDB0060512","HMDB:HMDB0041334","HMDB:HMDB0039788","HMDB:HMDB0003585; KEGG:C01962","HMDB:HMDB0009499; KEGG:C00350","HMDB:HMDB0034683","HMDB:HMDB0029343","HMDB:HMDB0029790","HMDB:HMDB0011504","HMDB:HMDB0030076","HMDB:HMDB0002220","HMDB:HMDB0007007","HMDB:HMDB0010400; KEGG:C04230","HMDB:HMDB0009801; KEGG:C00626","HMDB:HMDB0008846; KEGG:C00350","HMDB:HMDB0034702","HMDB:HMDB0039542","HMDB:HMDB0033060","HMDB:HMDB0014324","HMDB:HMDB0009284; KEGG:C00350","HMDB:HMDB0007338","HMDB:HMDB0041860","HMDB:HMDB0012290; KEGG:C04144","HMDB:HMDB0041224","HMDB:HMDB0115206","HMDB:HMDB0009155; KEGG:C00350","HMDB:HMDB0029895","HMDB:HMDB0060503","HMDB:HMDB0032918","HMDB:HMDB0009448; KEGG:C00350","HMDB:HMDB0003154; KEGG:C08583","HMDB:HMDB0041590","HMDB:HMDB0011505","HMDB:HMDB0038909","HMDB:HMDB0038883","HMDB:HMDB0040487","HMDB:HMDB0012285","HMDB:HMDB0032799","HMDB:HMDB0015554","HMDB:HMDB0030087; KEGG:C10545","HMDB:HMDB0039741","HMDB:HMDB0014465; KEGG:C07798","HMDB:HMDB0038862","HMDB:HMDB0303943; KEGG:C01617","HMDB:HMDB0115208","HMDB:HMDB0009187; KEGG:C00350","HMDB:HMDB0009770; KEGG:C00350","HMDB:HMDB0112342","HMDB:HMDB0034195","HMDB:HMDB0029548; KEGG:C10039","HMDB:HMDB0038406","HMDB:HMDB0038934","HMDB:HMDB0015590","HMDB:HMDB0030275","HMDB:HMDB0034902","HMDB:HMDB0041088","HMDB:HMDB0004135; KEGG:C05723","HMDB:HMDB0037058","HMDB:HMDB0039786","HMDB:HMDB0014900; KEGG:C16641","HMDB:HMDB0014939","HMDB:HMDB0035923","HMDB:HMDB0060376","HMDB:HMDB0009188; KEGG:C00350","HMDB:HMDB0015057; KEGG:C08007","HMDB:HMDB0015139","HMDB:HMDB0009158; KEGG:C00350","HMDB:HMDB0009213; KEGG:C00350","HMDB:HMDB0009459; KEGG:C00350","HMDB:HMDB0014698; KEGG:C08095","HMDB:HMDB0009180; KEGG:C00350","HMDB:HMDB0030448","HMDB:HMDB0030090; KEGG:C09833","HMDB:HMDB0033471","HMDB:HMDB0004634","HMDB:HMDB0115412","HMDB:HMDB0034692","HMDB:HMDB0014469","HMDB:HMDB0014934; KEGG:C07468","HMDB:HMDB0013913","HMDB:HMDB0014868; KEGG:C07131","HMDB:HMDB0014746; KEGG:C07625","HMDB:HMDB0115298","HMDB:HMDB0011678","HMDB:HMDB0254834","HMDB:HMDB0253207","HMDB:HMDB0014813; KEGG:C07108","HMDB:HMDB0015428; KEGG:C06897","HMDB:HMDB0040198","HMDB:HMDB0015360; KEGG:C07394","HMDB:HMDB0240224","HMDB:HMDB0060102","HMDB:HMDB0003023; KEGG:C03427","HMDB:HMDB0000269; KEGG:C00836","HMDB:HMDB0002117; KEGG:C19670","HMDB:HMDB0000254; KEGG:C00042","HMDB:HMDB0005794; KEGG:C00389","HMDB:HMDB0015330; KEGG:C07547","HMDB:HMDB0302732; KEGG:C17763","HMDB:HMDB0000115; KEGG:C00160"]}}