These metabolites were annotated using the KEGG database (https://www.genome.jp/kegg/pathway.html) , HMDB database (https://hmdb.ca/ metabolites) and LIPIDMaps database (http://www.lipidmaps.org/). Principal components analysis (PCA) and Partial least squares discriminant analysis (PLS-DA)
were performed at metaX[6] (a flexible and comprehensive software for processing metabolomics data).We applied univariate analysis (t-test) to calculate the statistical significance (P-value).The metabolites with VIP > 1 and P-value< 0.05 and fold change≥2 or FC≤0.5 were considered to be differential metabolites. Volcano plots were used to filter metabolites of interest which based on log2(FoldChange) and -log10(p-value) of metabolites by ggplot2 in R language.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - positive - hilic","Liquid Chromatography MS - negative - hilic"],"chromatography_protocol":["UHPLC-MS/MS analyses were performed using a Vanquish UHPLC system (ThermoFisher, Germany) coupled with an Orbitrap Exploris 120 mass spectrometer (Thermo Fisher, Germany) in Bioyi Biotechnology Co., Ltd. Wuhan, China.Samples were injected onto aHypersil Goldcolumn (100×2.1 mm, 1.9μm) using a 12-min linear gradient at a flowrate of 0.2 mL/min. The eluents for the positive polarity mode were eluent A (0.1%FA in Water) and eluent B (Methanol). The eluents for the negative polarity modewere eluent A (5 mM ammonium acetate, pH 9.0) and eluent B (Methanol ).The solvent gradient was set as follows: 2% B, 1.5 min; 2-85% B, 3 min; 85-100% B, 10min;100-2% B, 10.1 min;2%
B, 12 min.
"],"publication":["TRIM47 promotes cardiac ischemia/reperfusion injury."],"submitter_affiliation":["Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology"],"submitter_name":["2023XH0065 胡灿"],"organism_part":["heart"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Tissues (100 mg) were individually grounded with liquid nitrogen and the homogenate was resuspended with prechilled 80% methanol by well vortex. The samples were incubated on ice for 5 min and then were centrifuged at 15,000 g, 4°C for 20 min. Some of supernatant was diluted to final concentration containing 53% methanol by LC-MS grade water.The samples were subsequently transferred to a fresh Eppendorf tube and thenwere centrifuged at 15000 g, 4°C for 20 min. Finally, the supernatant was injected into the LC-MS/MS system analysis
"],"organism":["Mus musculus"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS14676"],"author":["Can Hu. Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. 1092749312@qq.com."],"data_transformation_protocol":["The raw data files generated by UHPLC-MS/MS were processed using the Compound Discoverer 3.3 (CD3.3, ThermoFisher) to perform peak alignment, peak picking, and quantitation for each metabolite. The main parameterswere set as follows:peak area was corrected with the first QC, actual mass tolerance, 5ppm; signal intensity tolerance, 30%; and minimum intensity, et al. After that, peak intensities were normalized to the total spectral intensity.The normalized data was used to predict the molecular formula based on additive ions, molecular ion peaks and fragment ions. And then peaks were matched with the mzCloud (https://www.mzcloud.org/)
mzVault and MassList database to obtain the accurate qualitative and relative quantitative results.Statistical analyses were performed using the statistical software R (R version R-3.4.3), Python (Python 2.7.6 version) and CentOS (CentOS release 6.6), When data were not normally distributed, standardize according to the formula: sample raw quantitation value / (The sum of sample metabolite quantitation value /The sum of QC1 sample metabolite quantitation value ) to obtain relative peak areas; And compounds whose CVs of relative peak areas in QC samples were greater than 30% were removed, and finally the metabolites' identification and relative quantification results were obtained.
"],"study_factor":["Treatment"],"submitter_email":["1092749312@qq.com"],"sample_collection_protocol":["Following cervical dislocation for euthanasia, the mouse was placed in a supine position. A midline thoracotomy was performed to expose the thoracic cavity. The pericardium was carefully opened to visualize the heart. The whole heart was excised, gently rinsed with ice-cold PBS to remove residual blood, and promptly transferred into a pre-chilled cryovial or fixative solution. The harvested tissue was immediately labeled and transported on dry ice or in liquid nitrogen to maintain RNA/protein integrity. All instruments were cleaned between samples to prevent cross-contamination.'
"],"omics_type":["Metabolomics"],"study_design":["Thermo Scientific Vanquish UHPLC System","Metabolomics","Ubiquitination","Mus musculus","untargeted analysis","Thermo Scientific Orbitrap Exploris 120","TRIM47","mitochondrial dysfunction","experimental blank","heart","untargeted metabolite profiling"],"curator_keywords":["Thermo Scientific Vanquish UHPLC System","Metabolomics","Ubiquitination","Mus musculus","untargeted analysis","Thermo Scientific Orbitrap Exploris 120","TRIM47","mitochondrial dysfunction","experimental blank","heart","untargeted metabolite profiling"],"mass_spectrometry_protocol":["Q ExactiveTM HF mass spectromete r was operated in positive/negative polarity mode with spray voltage of 3.5 kV, cap illarytemperature of 320°C, sheath gas flow rate of 35 psi and aux gas flow rate of 10L/min, S-lens RF level of 60, Aux gas heater temperature of 350°C.
"],"metabolite_name":["[(2R)-1-[(Z)-octadec-11-enoyl]oxy-3-phosphonooxypropan-2-yl] (Z)-icos-11-enoate","[(2R)-1-phosphonooxy-3-[(Z)-tetradec-9-enoyl]oxypropan-2-yl] (Z)-tetracos-15-enoate","1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)","Xanthosine-5'-monophosphate","PE-NMe(15:0/22:4(7Z,10Z,13Z,16Z))","(±)8-HETE","1,2-Diacylglycerol-LD-SM-pool","2-Butyne-1,4-diol","1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphoglycerol","Cyhalofop-butyl","Hydroxyatrazine","Ethyl gallate","6-Thiouric acid","5,8,11,14-Eicosatetraenoic acid, (1R)-1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxooctadecyl)oxy]ethyl ester, (5Z,8Z,11Z,14Z)-","Ketoleucine","L-Histidine","L-Allothreonine","Tacrine","9(S),12(S),13(S)-TriHOME","Cis-8,11,14,17-Eicosatetraenoic acid","Coumatetralyl","FFA(18:1)","Thymidine-5'-triphosphate","Butanone acid","Citrulline","1,5-Naphthalenediamine","Asperuloside","Alloxan","Flavin mononucleotide","L-Leucyl-L-alanine","Carboprost","1,2-Dioctadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)","S-nitrosoglutathione","Dehydrohistidyltryptophyldiketopiperazine","3,4-Dihydroxymandelic acid","1-Caffeoyl-beta-D-glucose","Maltitol","9-Octadecynoic acid","PE-NMe(18:1(9Z)/15:0)","Taurohyocholate","thromboxane B2","L-fuconic acid","(r)-3-Amino-4-methylpentanoic acid","N-Phenylacetylglycine","Balfourodinium","Lamivudine","[(2S)-2-pentadecanoyloxy-3-[(Z)-tetradec-9-enoyl]oxypropyl] (6Z,9Z,12Z,15Z)-octadeca-6,9,12,15-tetraenoate","Arachidonoyl LPA","(9E,11E)-Octadecadienoic acid","Fexofenadine","4,4'-Sulfonyldiphenol","6-Methylmercaptopurine","R788 disodium","3-Hydroxybenzo(a)pyrene","3-Oxoadipic acid","Lysophosphatidic acid","Arabinonic acid","12-OxoETE","Oleamide","4-Acetamidobenzoic acid","Cinnamic Acid","Salicylamide","15-Demethylaclacinomycin T","Thiazolidine-4-carboxylic acid","PA(22:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Pantothenic acid","2-Propylglutaric acid","PC(20:5(5Z,8Z,11Z,14Z,17Z)/20:5(5Z,8Z,11Z,14Z,17Z))","2'-Deoxyguanosine-5'-diphosphate","Glyceraldehyde","4-Methoxyphenylacetic acid","Ursocholic acid","BW-245C","Dodecanedioic Acid","2,6-di-tert-butyl-1,4-benzoquinone","Xanthurenic acid","(±)15-HETE","LPE(0:0/18:0)","Indoleacetaldehyde","(2R)-2-azaniumyl-3-(methylsulfanyl)propanoate","Carnitine C18:0","Monoisobutyl phthalate","Vanillic acid","1,5-dihydrocoenzyme F420","(2R)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid","Rucaparib","Thiacremonone","Mupirocin","3-tert-Butyl-4-hydroxyanisole","Prostaglandin D3","1,2-Dimyristoyl-sn-glycero-3-phosphocholine","[(2R)-2-hexadecanoyloxy-3-phosphonooxypropyl] 20-methylhenicosanoate","Isorhamnetin","3-Dehydroquinic acid","Adenosine-5'-phosphosulfate","4-Hydroxyquinoline","3-Butyn-1-al","Desfesoterodine","2,5-Dimethoxy-4-(ethylthio)phenethylamine","Rhamnose","4-Oxoniocarbonylbenzoate","3'-Adenylic acid","Lyxo-2-Hexulose","N-Palmitoyl Taurine","Dimethylarsinic acid","3-Hydroxybenzoic acid","FFA(16:0)","Sambutoxin","threo-3-methyl-L-aspartic acid","3-Methylphenylacetic acid","15-keto-prostaglandin E2","3,7-Dimethyluric acid","Monomethyl fumarate","Naphthyl-2-methyl-succinic acid","2,5-Dichloro-1,4-benzoquinone","8-Geranylumbelliferone","Calcium carbimide","LPE(0:0/18:2)","Melphalan","4-Hydroxybutyric acid","Tagatose","13-OxoODE","Methazolamide","Adenosine","Adenosine monophosphate","Glucosaminic acid","9-OxoODE","(S)-2-Aceto-2-hydroxybutanoic acid","Cyasterone","FFA(16:1)","PA(18:4(6Z,9Z,12Z,15Z)/24:0)","Acitretin","Dihydroartemisinin(DHA)","D-Erythrose 4-phosphate","PA(18:3(6Z,9Z,12Z)/22:0)","Noladin ether","PA(20:4(5Z,8Z,11Z,14Z)/22:4(7Z,10Z,13Z,16Z))","20-Carboxy-leukotriene B4","Hydrocortisone acetate","Benzoic acid","Avermectin A2a aglycone","4-Hydroxyretinoic Acid","Candesartan","1,1,1-Trifluoroheptadecan-2-one","D-Quinovose","e-64","1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoserine","PA(22:0/20:4(8Z,11Z,14Z,17Z))","Methionol","Traumatic acid","Tetradecanedioic acid","Epoxypheophorbide a","Docosahexaenoic acid","Erythritol","Sedoheptulose 1,7-bisphosphate","1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine","prostaglandin A2","1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine","meso-2,3-Butanediol","Quininae","2-Methyl-D-serine","Zaluzanin C","(S)-10,16-Dihydroxyhexadecanoic acid","Glycyrrhizin","Biosone","Tryptophylglycine","3-Hydroxypropanoic Acid","Terephthalic acid","1-(9Z-octadecenoyl)-2-docosanoyl-sn-glycero-3-phosphoethanolamine","Docosadienoate (22:2n6)","PE(18:0/20:3(5Z,8Z,11Z))","DL-Glyceraldehyde 3-Phosphate","α-Ketoglutaric Acid (α-KG)","PE-NMe2(18:1(11Z)/20:5(5Z,8Z,11Z,14Z,17Z))","Abietic acid","DG(22:0/22:5(4Z,7Z,10Z,13Z,16Z)/0:0)","Avermectin A1a aglycone","4-Hydroxy Triamterene","Amebacilin","N(4)-Acetylsulfamethazine","D-Arabinose","1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine","(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid","Fosfluconazole","Succinic anhydride","Xanthosine 5'-triphosphate","3-Aminocaproic acid","Dl-Lyxose","Erythrono-1,4-lactone","Guanine","4',6'-Dihydroxy-2'-methoxyacetophenone 6'-glucoside","cis-Dihomoaconitic acid","NADH","Ethynodiol diacetate","1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine","Thiourea","Adenosine 5'-Diphosphate","(5S)-3-(2-aminoethylsulanyl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid","LPA(18:2(9Z,12Z)/0:0)","Petroselinic acid","(R)-2-hydroxystearic acid","N-(3-Aminopropyl)-4-methyl-2-nitrobenzenamine","Desaminotyrosine","[(2R)-2-(14-methylhexadecanoyloxy)-3-phosphonooxypropyl] 22-methyltricosanoate","Tyrphostin A25","1-Methyladenine","3-Hydroxy-3-methyloxindole","1-(Malonylamino)cyclopropanecarboxylic acid","(5S,6R,7E,9E,11Z,14Z)-6-[(2S)-2-amino-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid","N'-Hydroxybenzenecarboximidamide","FFA(14:0)","3-Methyl-2-butenal","5-O-phosphono-alpha-D-ribofuranose","Tylactone","VINYL CHLORIDE","Tauroursodeoxycholic acid","Pravastatin","Glycocholic acid","Fenoldopam","Dehydro-D-arabinono-1,4-lactone","S-Sulfo-L-Cysteine","2,7-Dihydroxy-5-methyl-1-naphthoic acid","Indole-3-carboxaldehyde","Stearic acid","Flavin adenine dinucleotide","Orotidine","[(2S)-2-azaniumyl-2-carboxyethyl] [(2R)-2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl] phosphate","Beta-Tyrosine","Uridine-5'-diphosphate-glucose","Cinnamoylglycine","Adrenochrome","Salicylhydroxamic acid","Guanosine 3',5'-Cyclic Monophosphate","Geranic acid","L-cystathionine","7,8,17-trihydroxy-4,9,11,13,15,19-docosahexaenoic acid","1-(9Z-octadecenoyl)-2-hexadecanoyl-glycero-3-phosphoserine","Agomelatine","6-trans-12-epi Leukotriene B4","Ala-Tyr","O-acetyl-L-serine","Monobutyl phthalate","(R)-3,7-Dimethyl-1,6-octadien-3-ol","Gadusol","Uridine-diphosphate-N-acetylglucosamine","2'-Deoxyadenosine-5'-monophosphate","(E)-1,7-bis(4-hydroxyphenyl)hept-4-en-3-one","3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione","2-Methylheptanoic acid","Linifanib","Alpha-Ketooctanoic acid","Genistein","5-Methoxyindoleacetate","Adenylosuccinic acid","7-Methyluric acid","17beta-Estradiol 3-(beta-D-glucuronide)","Penicillamine","2-(2-Methylthioethyl)malic acid","Fingolimod phosphate","Glyoxylic acid","UDP-D-galactose","Meldonium","LPE(0:0/16:0)","Annoglabasin F","Treprostinil","Phenylethyl primeveroside","4-O-beta-D-glucosyl-4-coumaric acid","Taurolithocholic acid 3-sulfate","8-Desoxygartanin","Fluorouracil","3,4-Dihydroxy-5-methoxybenzoic acid","Gramine","13,16,19-Docosatrienoic acid","5,8,14-Eicosatrienoic acid, 11,12-dihydroxy-, (5Z,8Z,14Z)-","Thymine","Dobutamine","3-Oxopentanoic acid","Biocytin","Moclobemide","1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoserine","Pelargonic acid","DL-Leucine","(4E,6E)-1-(4-hydroxyphenyl)-7-phenylhepta-4,6-dien-3-one","1-Methyladenosine","Trp-Thr","Lorcainide","1-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol","TxB3","D-Ribose","L-fucopyranose 1-phosphate","LPE(0:0/16:1)","RvD1","Galactose","Zymosterol","24-Epi-campesterol","6-keto-PGF1α","1-Naphthol","4-Hydroxyisophthalic acid","Hydrocinnamic acid","p-Cresol sulfate","cytidine monophosphate N-acetylneuraminic acid","4-Chloro-2-methylphenol","leukotriene E4","13-oxoODE","L-Threonine","beta-D-Galp-(1->3)-D-GalpNAc","12(13)Ep-9-KODE","Acridine-9-amine","N-ethylene glycol neuraminic acid","8-Amino-7-oxononanoic acid","3-Hydroxyvalproic acid","2-Hydroxy-2H-benzo[h]chromene-2-carboxylate","Pentitol","Myristoleic acid","DG(18:4(6Z,9Z,12Z,15Z)/22:5(4Z,7Z,10Z,13Z,16Z)/0:0)","Febuxostat","8-Hydroxyguanosine","Inosine triphosphate","1-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine","beta-D-Fructose 6-phosphate","Ganoderic acid A","3-Azaniumyl-4-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)amino]-4-oxobutanoate","Sorbitol-6-phosphate","leukotriene D4","Se-methylselenocysteine","Phe-Met","trans-Vaccenic acid","N6-Succinyl Adenosine","8-Epi-prostaglandin F2alpha","Guanosine-5'-monophosphate","cis-11-Eicosenoic acid","11-Hdohe","4-Chlorophenol","d-Myo-inositol 4-monophosphate ammonium salt","(3Z)-Phycoerythrobilin","3-Hydroxydodecanoic acid","[(2S)-2-decanoyloxy-3-hydroxypropyl] docosanoate","Nialamide","6-ketoprostaglandin E1","9(S)-HpODE","9-Fluorenone","2-Naphthalenesulfonic acid","AICA ribonucleotide","trans-Aconitic acid","L-Alanyl-L-tryptophan","L-Palmitoylcarnitine","Cembra-2,7,11-triene-4,6-diol","9,10-EpOME","4-Vinylphenol sulfate","N-lactoyl-Valine","4-Amino-2-methyl-1-naphthol","Arabinose-5-phosphate","Tioxolone","cis,cis-Muconic acid","L-Tryptophan","Adouetine X","(Hydroxymethyl)phosphonic acid","N-Acetyl-a-neuraminic acid","LPC(15:0/0:0)","Isoliquiritin","PG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","4-Hydroxycrotonic acid","Deprenyl","(6b,7b,13R)-6,7-Diacetoxy-8,14-labdadiene-13-ol","2-Oxo-4-phosphonobutanoate","Butalbital","FFA(22:5)","Santonin","Eicosadienoic acid","(8S,9S,10R,11R,13S,14S,17R)-17-acetyl-11,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one","Asn-Trp","1-Palmitoyl-2-oleoyl-sn-glycero-3-(phospho-rac-(1-glycerol))","dl-O-Phosphoserine","2-Hydroxyhexadecanoic acid","2-methyl citric acid","Myosmine","Eicosapentaenoic acid","Uracil","s-Hexylglutathione","2-Thiouracil","Tryptamine","1-(9Z,12Z-octadecadienoyl)-2-eicosanoyl-glycero-3-phosphate","8,9-Epoxyeicosatrienoic acid","Deoxyguanosine 5'-monophosphate(dGMP)","(±)9-HpODE","Carnosic acid","Alpha-Phosphoribosylpyrophosphoric Acid","1-octadecanoyl-2-(13Z,16Z-docosadienoyl)-glycero-3-phosphate","Ostruthin","Creatine","N-(2,4-Dinitrophenyl)ethylenediamine","Sphingosine 1-phosphate","Inosinic acid","N-(2-Hydroxyethyl)nicotinamide","Caprylic acid","(R)-10-hydroxystearic acid","Maraviroc","Azacitidine","1-Phenyl-1,2-propanedione","prostaglandin E3","9-Oxo-nonanoic acid","Cholesterol sulfate","Behenic acid","2-Mercaptoethanesulfonic acid","D-Glucose 6-phosphate","1D-myo-inositol 1,4-bisphosphate","NBD-Stearoyl-2-Arachidonoyl-sn-glycerol","4-Oxopentanoate","2-benzyl-4-(octahydro-1H-isoindol-2-yl)-4-oxobutanoic acid","Acetylvalerenolic acid","2-Bromoacetaldehyde","Acadesine","Acetic acid","Adipic acid","O,O-Dimethyl dithiophosphate","1-Eicosanoyl-glycero-3-phosphate","Adrenic acid","N-Methyl-a-aminoisobutyric acid","Isomaltulose","4-Dodecylbenzenesulfonic acid","p-Toluenesulfonic acid","2-Hydroxymuconic semialdehyde","Acrylic acid","2-Oxovaleric acid","3-Hydroxypicolinic acid","1,7-Bis(4-hydroxyphenyl)-3-heptanone","2-Methylcholine","3-methylmalate(2-)","LPC(18:0/0:0)","[(2R)-2-[(Z)-octadec-11-enoyl]oxy-3-phosphonooxypropyl] (Z)-docos-13-enoate","H-Phe-D-met-arg-phe-NH2","LPE(20:5/0:0)","GDP-L-fucose","N6-Methylagmatine","Chromocarb","1-aci-nitro-2-(1H-indol-3-yl)ethane","Faicar","Naringenin-4'-o-beta-d-glucuronide","9-PAHSA","S-(5-Adenosy)-L-Homocysteine","5-oxoETE","Trp-Ala","2-Methylhippuric acid","Canrenone","PE-NMe2(18:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Threonic acid","Fructose","Acetamiprid","1,6-di-O-phosphono-beta-D-fructofuranose","prostaglandin B2","Heptadecanoic acid","gamma-Linolenic Acid","Ribose-1-phosphate","Uridine-5'-diphospho-N-acetylgalactosamine disodium salt","LPE(16:1/0:0)","PC(O-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Dimethylglycine","Isoacitretin","Asparagylalanine","Corchorifatty acid F","Darunavir","cis-3-Hexenyl acetate","5-O-beta-D-Mycaminosyltylactone","12-Oxo-phytodienoic acid","Phenylacetic acid","[(2R)-2-hexadecanoyloxy-3-phosphonooxypropyl] 22-methyltricosanoate","5-Aminoimidazole-4-carboxamide","Dihydroxyacetone phosphate","2-Amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioic acid","Pteridine","Palmitic acid","3-Hydroxyglutaric acid","4-oxo-4-(3-pyridyl)butyraldehyde","sn-Glycerol 3-phosphate","Trp-Leu","16-Hydroxyhexadecanoic acid","Convallatoxin","Imidazole-4-methanol","2'-Deoxyguanosine-5'-triphosphate","PE-NMe(18:1(9Z)/18:2(9Z,12Z))","Phosphoric acid","2-Amino-3-phosphonopropionic acid","Resolvin D2","Phenyl dihydrogen phosphate","Hydrogen carbonate","Esculin","2,4-Dichloro-5-oxo-2,5-dihydro-2-furylacetic acid","Benzenebutanoic acid","Propionic acid","Nervonic acid","12-Hydroxydodecanoic acid","Mevalonate 5-phosphate","9S,11R-dihydroxy-15-oxo-5Z-prostaenoic acid-cyclo[8S,12R]","Quercetin 3-O-(6''-acetyl-glucoside)","Ribonolactone","(3-Methoxy-4-hydroxyphenyl)ethylene glycol sulfate","1-Pentadecanoyl-glycerol","Quercetin","Dihydroxyfumaric acid","Glycerophospho-N-Arachidonoyl Ethanolamine","4-Hydroxyphenylacetylglycine","3-Methylglutaric acid","PE-NMe(16:0/16:0)","Ethionamide","Acetyl-maltose","LPA(22:1(13Z)/0:0)","12S-HHT","Succinic acid semialdehyde","Avermectin B1a aglycone","9-Decenoic acid","14,15-Epoxyeicosa-5z-enoic acid","PC(P-18:0/20:4(5Z,8Z,11Z,14Z))","Resolvin E1","8-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid","Hydroxyphenyllactic acid","Salicylic acid","1-Arachidonyl-2-palmitoleoyl-sn-glycerol","Erythrose","(R)-3-Hydroxy-tetradecanoic acid","Pyropheophorbide a","PG(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","Mannitol 1-phosphate","2,3-Dihydroxy-4-methoxybenzoic acid","[(2R)-2-(14-methylpentadecanoyloxy)-3-phosphonooxypropyl] docosanoate","19,20-DiHDPA","Propylparaben","Uridine diphosphate glucuronic acid","7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin","Dichlorprop-P","LPS(22:6)","Acteoside","Pro-Tyr","Phosphatidylglycerol(18:1/16:0)","2-(alpha-D-mannosyl)-3-phosphoglyceric acid","Glyphosate","Repaglinide aromatic amine","1-(9Z-octadecenoyl)-2-(7Z,10Z,13Z,16Z-docosatetraenoyl)-sn-glycerol","4-Amino-3-hydroxybutyrate","Leukotriene A4","Maleic acid","FFA(20:0)","Pov-pc","Mercaptopurine","4-Methoxy-2,4-dioxobutanoic acid","7-Methylxanthine","16-Oxohexadecanoic acid","Indoxyl sulfate","Azosemide","2-dehydro-3,6-dideoxy-6-sulfo-D-gluconic acid","Galactaric acid","4,7-Diphenyl-1,10-phenanthroline","2-Furoic acid","3,4,5-trihydroxy-6-({11-methoxy-13-oxo-6,8,20-trioxapentacyclo[10.8.0.0(2),.0(3),.0(1),(1)]icosa-1(12),2(9),4,10,14(19),15,17-heptaen-15-yl}oxy)oxane-2-carboxylic acid","Undecanedioic acid","D-fructofuranose","Phenobarbital","Irbesartan","3,7-Dihydroxy-12-oxocholanoic acid","2-Hydroxy-2-methylbutyric acid","Salvinorin A","2-Chlorophenol","Methyl acetate","Daphnoretin","Dehydrozingerone","Pyruvaldehyde","Sedoheptulose","DG(20:5(5Z,8Z,11Z,14Z,17Z)/24:1(15Z)/0:0)","Epigallocatechin","Deoxycytidine diphosphate","PGF3α","3,3',4',5,5',7-Hexahydroxyflavylium","2,3-Dihydroxy-1,4-dithiobutane","3,4-Dihydroxyhydrocinnamic acid","LPI(18:1)","L-3-Phenyllactic acid","4-Hydroxyphenylpyruvic acid","Dodecyl glucopyranoside","Chlorohydroquinone","12-Keto-leukotriene B4","3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholestan-26-oic acid","LPE(0:0/20:5)","Leu-Ser","Mifepristone","(E)-but-2-enedioate;hydron","Polydatin","2-Hydroxymyristic acid","Atazanavir","Inositol 1-phosphate","Hexadecenoic acid","Sedoheptulose 7-phosphate","Glycolaldehyde","D-galactaro-1,4-lactone","Pyridoxal phosphate","Neogrifolin","1-Heptadecanoyl-sn-glycero-3-phosphocholine","[6]-Gingerdiol 3,5-diacetate","1-Hydroxypyrene","prostaglandin J2","2,3-Dimercaptosuccinic acid","Norbuprenorphine","d-Myo-inositol-1,4,5-triphosphate","Methylmalonic Acid","Allyltetramethoxybenzene","Aminohippuric acid","Octadec-9-ene-1-carboxylic acid","Pgp(16:1(9Z)/18:1(9Z))","2,2'-Biphenol","1,2-Distearoyl-sn-glycero-3-phosphocholine","Fluoroacetic acid","Cys-Thr","Riboflavin","N-Isovaleroylglycine","Ramipril","3,3-Dimethylglutaric acid","2-Hydroxy-3-Methylbutanoic Acid","Folic acid","Isoguvacine","4-Carboxy-2-hydroxy-cis,cis-muconic acid","Glu-Leu","(Z)-7-[(2R,3S,4S,6S)-4,6-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]oxan-3-yl]hept-5-enoic acid","N-Acetylvaline","PA(20:4(5Z,8Z,11Z,14Z)/18:4(6Z,9Z,12Z,15Z))","2,3-dinor-8-iso Prostaglandin F2α","10-nitro-9E-octadecenoic acid","Hexanoylglycine","2-Methylbenzoic acid","2-Methyl-1-methylthio-2-butene","Dimethyl hydrogen phosphate","Mesotartaric acid","m-Aminobenzoic acid","15(S)-Hydroxyeicosatrienoic acid","Tramiprosate","PE-NMe2(18:3(9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Nitecapone","Prednisolone acetate","Isorutarin","Medica 16","alpha-Muricholic acid","Paxilline","3-Hydroxy-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-octanamide","1-Methylxanthine","Uridine-5'-monophosphate","2-((3-Aminopropyl)amino)ethanethiol","(3S,3aS,6R,8aS)-3,8-Dimethyl-5-(propan-2-ylidene)-2,3,4,5,6,8a-hexahydro-1H-3a,6-epoxyazulen-6-ol","Mesaconic acid","Nordihydrocapsiate","1-deoxy-D-xylulose 5-phosphate","[2-hydroxy-3-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate","5-Hydroxyindoleacetic acid","Endomorphin 2","Silicristin","Valylserine","Aucubin","Dehydrocorticosterone","1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-3'-phosphate)","Ethyl sulfate","Glycine","Ureidopropionic acid","1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol)","(25R)-Delta(4)-dafachronic acid","Cystathionine","2-Hydroxyquinoline","Sclareol","5S-Hydroxy-6R-(S-gamma-glutamylcysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid","Echinorine","DL-Serine","Morin","Val-Phe","Miglitol","5-Hydroxytryptophol","PE-NMe2(18:1(9Z)/18:1(9Z))","13-Methylmyristic acid","N-Heptanoylglycine","Pseudouridine","DL-Pantothenic acid","2-Methylglutaric acid","Sodium salicylate","L-Formylkynurenine","2-Ethyl-2-Hydroxybutyric acid","LPE(18:1/0:0)","Allotetrahydrocorticosterone","Chelidonic acid","4-Pyridoxic acid","3-Hydroxymugineic acid","Guanosine","3-Hydroxydecanoic acid","15-Deoxy-delta-12,14-prostaglandin J2","Myricetin","Pinoresinol","Oleoyltaurine","3-Methylxanthine","2,3,4,5-Tetrachloro-4'-biphenylol","Keto-Deoxy-Nonulonic acid","Glyceric acid","1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholine","Lactaldehyde","Hexadecanedioic acid","PE-NMe(14:1(9Z)/22:5(4Z,7Z,10Z,13Z,16Z))","3-Phenylbutyric acid","LPI(16:0)","Clozapine N-oxide","Cyclic AMP","Loganin","Chicoric acid","Cytochalasin a","Amifostine","Homocitric acid","Daidzein 4'-O-glucuronide","Xylose","trans-trans-Muconic acid","delta-(L-2-Aminoadipyl)-L-cysteinyl-D-valine","L-Thyronine","Oxalacetic acid","Pyrophosphate","1-(9Z-hexadecenoyl)-2-(9Z-octadecenoyl)-glycero-3-phosphoserine","Uridine","Avermectin B1b aglycone","9-Oxo-11-(3-pentyloxiran-2-YL)undec-10-enoic acid","LPE(20:4/0:0)","1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphate","Dihydrogen phosphate","Isovanillic acid","Icaritin","Equol","Isopentenyladenine","Puromycin","PC(20:3(8Z,11Z,14Z)/14:0)","3-Hydroxymethylglutaric acid","2,4-didehydro-3-deoxy-L-rhamnonic acid","4-Methylhippuric acid","Aspartic acid","Liquiritin","Hydroxyisoleucine","Glutathione Reducedform","Ile-Ser","N-Methyltryptamine","1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine","(Z)-7-[(2R)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1R)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid","Suberylglycine","Chlordiazepoxide","5-Acetamidovalerate","1-Palmitoylglycerol 3-phosphate","2,5-Dihydropyridine","Avermectin B2a aglycone","Homogentisic acid","Fumaric acid","L-Tyrosine","PA(14:1(9Z)/20:5(5Z,8Z,11Z,14Z,17Z))","Sulfoacetic acid","Betamethasone","3-Methoxy-4',5-dihydroxy-trans-stilbene","PC(16:0/20:4(5Z,8Z,11Z,14Z))","3-Hydroxycinnamic acid","PE-NMe(18:3(6Z,9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z))","10-Carboxy-13-deoxycarminomycin","4-Oxo-4-(pyridin-3-yl)butanoic acid","19-epi-Ajmalicine","Sapanisertib","Desethylamodiaquine","Mannose","Glucose","D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate","D-Glucaro-1,4-lactone","Butyrate","Phe-Cys","(3S,4S,6S)-2-methyl-6-[(4S,5R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol","LPS(18:3)","Thymidine-5'-phosphate","PA(18:1(9Z)/22:2(13Z,16Z))","Glcnac6P","Cortexolone","2,5-Dihydroxybenzaldehyde","16(17)-EpDPE","1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine","Methoxyacetic acid","fuconic acid","Taurocholic acid","1-O-vanillyl-β-D-glucose","2-Keto-3-deoxy-6-phosphogluconate","2-Dodecylbenzenesulfonic acid","Tarennoside","3-Oxalomalic acid","2-(Methylthio)methyl-2-butenal","1,3-Dimethyluric acid","Alnustone","DG(18:1(9Z)/18:4(6Z,9Z,12Z,15Z)/0:0)","LPE(18:0/0:0)","11-Dehydro-thromboxane B2","Oleic estolide","Imidafenacin","LPS(18:2)","N-(2-Furoyl)glycine","PE(20:1(11Z)/22:2(13Z,16Z))","Hydroxyoctanoic acid","Ureidoisobutyric Acid","Egtazic acid","(±)12-HETE","Valsartan","2,4-Dichlorobenzoic acid","Suberic acid","[(2S)-2-pentadecanoyloxy-3-[(Z)-tetradec-9-enoyl]oxypropyl] (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate","1-pentadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine","3-Pyridinemethanol","Acetylsalicylic acid","PE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","DG(18:3(6Z,9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z)/0:0)","3-Methoxyanthranilate","thiamin-PPi","PA(18:3(9Z,12Z,15Z)/24:1(15Z))","4-Nitrophenol","Octadecanamide","Rhodotoxine","Benzimidazole","(±)13-HpODE","PG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/20:2(11Z,14Z))","Carnitine C2:0","Lonchocarpol A","Creatinine","4-Carboxy-4'-sulfoazobenzene","PA(22:0/20:4(5Z,8Z,11Z,14Z))","(1S)-1,23,25-trihydroxy-24-oxocalciol","dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose","Methyl hexadecanoic acid","Pimelic acid","2,2-Dimethylsuccinic acid","cis-7-Hexadecenoic acid","4-(Butoxymethyl)-2-methoxyphenol","6-Phosphogluconic acid","1-(9Z-octadecenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycerol","Fludarabine phosphate","5-Aminopentanoic acid","11,12,15-THETA","Glycolithocholic acid","N,N-Dimethylformamide","N-Acetylleucine","Oglufanide","4-Hydroxystyrene","Etiocholanedione","Gamma-Mercholic Acid","3,8-Dihydroxy-1-methylanthraquinone-2-carboxylic acid","3-Methoxysalicylic acid","Tiglic acid","5,8,11-Eicosatrienoic acid","PA(22:1(13Z)/20:5(5Z,8Z,11Z,14Z,17Z))","Ritterazine A","Methylparaben","(r)-Methylmalonate semialdehyde","LPE(20:3/0:0)","Tenofovir","Itaconic acid","2-Benzylmalate","Glycerophosphoric acid","L-Ascorbyl 6-palmitate","Betaine","L-Alanine","2-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-3-one","Glu-Tyr","N-arachidonoylglycine","Jasmonic acid","Norethindrone acetate","3-Formylsalicylic acid","LPE(22:4/0:0)","1-Aminocyclopropane-1-carboxylic acid","6-Acetylmorphine","beta-Alanine amide","4-(Glutamylamino)butanoate","D-Fructose-6-phosphate","PC(18:0/18:2)","Heneicosanoic acid","N-Acetyl-L-aspartic acid","Lobeline","trans-2,3-Epoxysuccinic acid","13(S)-Hydroperoxylinolenic acid","Acetaminophen glucuronide","Indole-3-lactic acid","Shogaol","4-Carboxy-2-oxo-3-hexenedioate","Phosphoserine","APMF-Glu","alpha-Methylene-gamma-butyrolactone","(6E,8E,10E,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid","TG(14:1(9Z)/14:1(9Z)/18:4(6Z,9Z,12Z,15Z))","Bupirimate","(±)12-HEPE","3-Hydroxyisovaleric acid","PA(18:1(9Z)/18:1(9Z))","Montanin","3-(4-Methoxyphenyl)propanoic acid","(±)5-HETE","10-Hydroxydecanoic acid","Isopimaric acid","Phytolaccasaponin G","Endomorphin-1","2-dehydropantoate","19(S)-HETE","4-Methylvaleric Acid","5beta-Cholanic acid","5-Oxo-4,5-dihydro-2-furylacetic acid","2-Hydroxyoctadecanoic acid","5-O-Methyllicoricidin","2-Hydroxyethanesulfonic acid","(2S,3R,5R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one","Indoprofen","D-Glucose 6-Phosphate","D-Ribulose 1,5-bisphosphate","Dexmedetomidine","Sinensetin","Piperidin-3-yl(pyrrolidin-1-yl)methanone","15-keto Prostaglandin F1α","Rosiglitazone","Lactic acid","Beta-Aminopropionitrile","Dichlorprop","1-Palmitoyl-2-oleoylglycero-3-phosphoglycerol","D-Fructose","Embelin","PE-NMe(15:0/20:1(11Z))","NCGC00385507-01_C14H17NO9_(2S)-7-Hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside","Formylanthranilic acid","5-Methoxy-L-Tryptophan","(9Z,12S,13R)-12,13-Dihydroxy-9-octadecenoic acid","L-Homoserine","9(S)-HPODE","1,11-Undecanedicarboxylic acid","Morusin","TG(14:0/14:1(9Z)/14:0)","Sparfloxacin","Cys-Tyr","N-Formylmethionine","(Z)-3-aminoperacrylic acid","3-Indoleacrylic acid","FFA(13:0)","1-Aminocyclohexanecarboxylic acid","Palmitoylethanolamide","2'-Deoxyinosine","Ciclopirox","alpha-Ketoisovaleric acid","N-lactoyl-phenylalanine","4-Methyloctanoic acid","Dexamethasone sodium phosphate","20-Hydroxy-leukotriene E4","Zopiclone","(+)-Gallocatechin","(S)-Nerolidol 3-O-[a-L-rhamnopyranosyl-(1->2)-b-D-glucopyranoside]","epi-Lipoxin A4","Glycerophospho-N-Palmitoyl Ethanolamine","2,4-Dichlorophenoxyacetic acid","m-Toluic acid","1-Hexanethiol","PA(20:5(5Z,8Z,11Z,14Z,17Z)/22:5(4Z,7Z,10Z,13Z,16Z))","Carnosine","3-(4-Hydroxyphenyl)chroman-7-ol","Spironolactone","3-Hydroxybutyrate","Glycolic acid","Xanthoxic acid","Valeryl-4-hydroxyvalsartan","3-Indolylmethyl glucosinolate","propionyl-CoA","Pentadecanoic acid","5,6-Dimethylbenzimidazole","LPS(18:1/0:0)","D-Xylulose 5-phosphate","1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine","Kojic acid","[(2R)-1-(19-methylicosanoyloxy)-3-phosphonooxypropan-2-yl] 22-methyltricosanoate","3',5'-Dihydroxyflavone","Estrone glucuronide","1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine","Capsianoside IV","3-(Methylthio)propionic acid","D-fructofuranose 1,6-bisphosphate","1-Octadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine","PC(14:0/22:5(4Z,7Z,10Z,13Z,16Z))","Indole-3-propionic acid","Plumieride","PA(20:4(5Z,8Z,11Z,14Z)/22:0)","8-Hydroxyquinoline","1,7-Dimethyluric acid","2-Methylene-3-methylsuccinic acid","Ribulose 5-phosphate","[(2S)-2,3-bis[[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]oxy]propyl] (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate","Juvenile hormone I acid","Aminocaproic acid","Adenosine-3'-5'-diphosphate","Xanthotoxol","Mimosine","PC(20:5(5Z,8Z,11Z,14Z,17Z)/20:1(11Z))","(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate","D-galactaro-1,5-lactone","3-Methyluridine","N-formylmaleamic acid","2-Deoxy-D-ribofuranose 5-phosphate","N-[(R)-4-phosphopantothenoyl]-L-cysteine","2-Acetylpyrazine","4-Ethyloctanoic acid","Valerenic acid","(-)-Gallocatechin","N-Linoleoyl Glycine","Dinoprost tromethamine","1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate","N-Acetyl-Neuraminic Acid","2'-Deoxyuridine 5'-monophosphate","3-Hydroxytetradecanoic acid","Ponasterone A","9,10-Dihydroxystearic acid","Lovastatin acid","D-ribofuranose 5-phosphate","1,2-Dichlorovinylthiol","3-Oxooctadecanoic acid","Dimethylmalonic acid","LPE(18:3/0:0)","Glyceraldehyde-3-phosphate","demethoxyfumitremorgin C","(2R,3S,4S,5R,6S)-2-[[(2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-(3,4,5-trimethoxyphenoxy)oxane-3,4,5-triol","Taurocyamine","Succinic acid","m-Chlorohippuric acid","Hypoxanthine","Bergaptol","16-Methylheptadecanoic acid","D-Amygdalin","Psilocybine","Dinoterb","Hippuric acid","alpha-Linolenic acid","(±)19(20)-EpDPE(A)","Zeatin riboside","Citalopram N-oxide","Arabinose","4-Chloro-3-methylphenol","Atractyloside A","1-docosanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol","L-Gulose","(9S,10S,12Z)-9,10-Dihydroxy-12-octadecenoic acid","Oxaloglutarate","Gamma-delta-Dioxovaleric acid","Ethyl tetradecanoate","2,4-Diamino-6-hydroxypyrimidine","Tropine","Citraconic Acid","1-Pyrroline-4-hydroxy-2-carboxylate","Gulose","Glutaconic acid","Adenine","Oxoadipic acid","(-)-3-Cyanomethyl-3-hydroxy-1H-indol-2(3H)-one","Cortisone","Isobutyric acid","L-Serine","Inosine","Alpha-d-xylopyranose","Homocysteine","Phenytoin","Lumichrome","Levonordefrin","Dioleoyl phosphatidylserine","Gartanin","Ouabain","Cholic acid","Arachidonic acid","LPE(14:0/0:0)","5beta-Pregnane-3alpha,21-diol-11,20-dione","Firefly luciferin","1,2,4-Trichlorobenzene","Erythorbic acid","(6S)-5,6,7,8-Tetrahydrofolate","3-[(1-Carboxyvinyl)oxy]benzoic acid","Tetranor-12(S)-hete","Methotrexate","Valylcysteine","Caffeine","Alliin","DG(22:0/20:5(5Z,8Z,11Z,14Z,17Z)/0:0)","Livalo","3-Hydroxybenzaldehyde","9-HEPE","D-Mannose 6-phosphate","Allocholic acid","(10)-Gingerol","Geniposidic acid","4-Hydroxybenzoic acid","Valproic acid","N-acetyl-alpha-D-glucosamine 1-phosphate","3-O-Methylquercetin","5-Chloro-2-fluorobenzimidamide","alpha-CEHC","Naphthalene","Dihydrouracil","L-Serine O-sulfate","2-Methylaminoethylphosphonic acid","Sphinganine 1-phosphate","1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-glycero-3-phospho-(1'-sn-glycerol)","Cys-Phe","Tetrahydrodeoxycorticosterone","(8)-Gingerol","Dioxindole","N-Formyl-L-aspartic acid","Theophylline","PA(20:4(5Z,8Z,11Z,14Z)/22:1(13Z))","Bovinic acid","D-erythro-Isocitric acid","Capecitabine","4-Tetradecanamidobenzylphosphonic acid","5-HEPE","Orotidylic acid","7-Ketodeoxycholic acid","Glycyl-L-tyrosine","17-Hydroxyandrost-4-en-3-one","Acetylenedicarboxylic acid","4-Ethylbenzoic acid","2-deoxy-5-O-phosphono-D-erythro-pentose","Salidroside","N-(3-methoxyphenyl)piperidin-4-amine","Acrylamide","Trp-Met","Sumiki's acid","(8Z,11Z,13E)-15-hydroxyicosa-8,11,13-trienoic acid","Pyroglutamic acid","1,3,5-Trihydroxybenzene","S-Glutathionyl-L-cysteine","3alpha-Hydroxy-5beta-pregnane-20-one sulfate","1-Myristoyl-sn-glycerol","Pinolidoxin","Coriolic acid","Chlormequat","Fludrocortisone acetate","11β-Prostaglandin F2α","1-(9Z,12Z-octadecadienoyl)-glycero-3-phosphate","L-glyceraldehyde","3-Hydroxyhexadecanoic acid","Picloram","Pyridoxamine phosphate","Gingerol","2-Hydroxy-6-pentadecylbenzoic acid","N-Acetyl-L-alanine","2-Hydroxybutanoic Acid","1,2-Dipalmitoyl-phosphatidyl-glycerole","alpha-Ribazole-5'-phosphate","16-Feruloyloxypalmitic acid","Phenyl acetate","TG(14:1(9Z)/14:1(9Z)/20:5(5Z,8Z,11Z,14Z,17Z))","2-Ketohexanoic acid","Thymidine","5beta-Dihydrocorticosterone","FFA(18:4)","3-Palmitoyl-sn-glycerol","1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol","D-Alanine","PA(22:1(13Z)/18:2(9Z,12Z))","Lactitol","Malic acid","Avermectin B2b aglycone","4-Methylbenzoic acid","Inositol","Bortezomib","Androsterone sulfate","3-(4-hydroxy-3,5-dimethoxyphenyl)oxirane-2-carboxylic acid","1-(9Z-hexadecenoyl)-2-(9Z-octadecenoyl)-glycero-3-phospho-(1'-sn-glycerol)","Secologanin","L-Gulonic acid","(R)-2-O-sulfolactic acid","Mandelic acid","(3R)-3-acetyloxy-3-[(1R,2R,5R,6R,7R,10S,11R,14S)-11-(furan-3-yl)-5-(2-hydroxypropan-2-yl)-2,6,10-trimethyl-3,13-dioxo-12,15-dioxatetracyclo[8.5.0.01,14.02,7]pentadecan-6-yl]propanoic acid","Maltose","Aloxistatin","PA(20:1(11Z)/18:2(9Z,12Z))","3-Phenylpropyl glucosinolate","3-deoxy-D-threo-hex-2-ulosaric acid","PA(18:3(6Z,9Z,12Z)/24:1(15Z))","Thiosalicylic acid","6-Dimethylaminopurine","(±)16-HETE","Oxypurinol","Pyruvic Acid","Leonurine","N-Methyl-D-aspartic acid","(s)-3-Amino-3-phenylpropanoic acid","12-Hydroxystearic acid","Talose","LPC(14:0/0:0)","Methionine sulfoxide","Guanosine-5'-diphosphate","Parabanic acid","Allantoic acid","Elaidic acid","PA(20:4(5Z,8Z,11Z,14Z)/20:1(11Z))","Ginkgolic acid","Ribavirin","Taurodeoxycholic acid","FFA(18:2)","Gluconapin","Azelaic 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shows that TRIM47 is upregulated in cardiomyocytes during cardiac I/R injury in an EGR1-dependent manner, correlating with injury severity. Cardiomyocyte-specific TRIM47 overexpression worsens, while TRIM47 knockout alleviates, I/R-induced cardiac injury and dysfunction. Mechanistically, TRIM47 promotes K63-linked ubiquitination of FOXO1 at lysine 210, inducing its nuclear translocation. Nuclear FOXO1 then inhibits HNF4A transcriptional activity, leading to mitochondrial dysfunction, fatty acid oxidation defects, and aggravated cardiac injury. Therapeutic knockdown of TRIM47 after I/R injury effectively prevents cardiac remodeling and dysfunction. The TRIM47/FOXO1/HNF4A axis represents a promising therapeutic target for cardiac I/R injury.","dates":{"publication":"2026-08-28","submission":"2026-06-05"},"accession":"MTBLS14676","cross_references":{"KEGG":["C00408","C14743","C02571","C00079","C02735","C00170","C00047","C00077","C00073","C00183","C00148","C01602","C00157","C00114","C01762","C00245","C00318","C00025","C00064","C00127","C01885","C00002","C01104","C00946","C00378","C00639","C03758","C00051","C00008","C00380","C03794","C74036","C02140","C00385","C00315","C01746","C00836","C01933","C01606","C00019","C03990","C14214","C01733","C01772","C00055","C01456","C09076","C06593","C00780","C00152","C07635","C05942","C00515","C00606","C03194","C00954","C00213","C05961","C16522","C06438","C00371","C17333","C00956","C04853","C01046","C02918","C05960","C17726","C00049","C00788","C00072","C03969","C05589","C19415","C06577","C14772","C05138","C10172","C10454","C00191","C00489","C08316","C00526","C02372","C14768","C01004","C14311","C10761","C00852","C02165","C06608","C00392","C00250","C02348","C03626","C00632","C17771","C00913","C00129","C19911","C11918","C00491","C02989","C01817","C04438","C10901","C00519","C02504","C06771","C06476","C17235","C01780","C03557","C05465","C00074","C15584","C00715","C11735","C02794","C03139","C12270","C06772","C14748","C02670","C06179","C15587","C00860","C72461","C05484","C00099","C03088","C00977","C16939","C02166","C00696","C00483","C06358","C00301","C01059","C01924","C02939","C00633","C00062","C00346","C06103","C00942","C00379","C02824","C05490","C01073","C09815","C17658","C01019","C02528","C00803","C01424","C02565","C20212","C00010280","C00113","C00328","C08306","C01555","C71930","C08733","C74541","C00477","C00534","C00158","C20669","C01243","C00535","C00568","C02679","C07112","C05771","C03205","C05958","C00896","C01235","C01537","C20045","C00735","C14777","C00588","C06414","C02721","C04548","C03065","C13870","C01386","C06325","C19915","C01718","C00438","C03079","C00344","C11519","C19138","C00123","C00747","C02237","C00550","C15205","C04230","C03299","C13856","C04873","C19434","C07195","C00261","C13861","C06556","C02990","C00362","C19766","C20808","C20895","C19426","C12144","C03690","C02693","C07471","C00641","C03519","C09365","C05576","C08301","C00407","C09840","C00217","C00184","C16310","C20313","C00427","C00446","C20487","C05956","C01403","C05979","C03927 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