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annotation was performed using an in-house R-based workflow with BiotreeDB version 3.0. Features were annotated based on matching retention time, precursor ion m/z, MS1 information and MS/MS spectra against reference and in-house databases. Metabolite identification levels were assigned according to the Metabolomics Standards Initiative (MSI): Level 1 for matches to authentic standards with MS1, MS2 and retention time; Level 2 for matches to public database MS1 and MS2 spectra; Level 3 for matches to theoretical database MS1, MS2 and predicted retention time; and Level 4 for unknown compounds.</p>"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - positive - hilic","Liquid Chromatography MS - negative - hilic"],"chromatography_protocol":["<p>LC separation was performed using a Vanquish UHPLC system (Thermo Fisher Scientific). Polar metabolites were separated on a Waters ACQUITY UPLC BEH Amide column (2.1 mm × 50 mm, 1.7 μm). Mobile phase A consisted of water containing 25 mmol/L ammonium acetate and 25 mmol/L ammonium hydroxide, and mobile phase B was acetonitrile. The autosampler temperature was maintained at 4 °C, and the injection volume was 2 μL.</p>"],"publication":["Penthorum chinense Pursh Ameliorates Metabolic Dysfunction-Associated Alcohol-Related Liver Disease through Gut Microbiota Modulation and Metabolic Remodeling."],"submitter_name":["Chen Kunzhui"],"submitter_affiliation":["Guangzhou University"],"organism_part":["liver"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["<p>Dried liver tissue samples were weighed, and 25 mg of each sample was transferred into an EP tube with two homogenization beads. Then 500 μL extraction solvent, consisting of methanol:acetonitrile:water at 2:2:1 (v/v/v) and containing isotope-labeled internal standards, was added. The mixture was vortexed for 30 s, homogenized at 35 Hz for 4 min, and sonicated in an ice-water bath for 5 min. The homogenization and sonication steps were repeated three times. Samples were incubated at -40 °C for 1 h. Then 300 μL of liquid was transferred to a 0.22 μm filter plate. The protein precipitation plate and collection plate were placed into a positive-pressure device and filtered at 6 psi for 180 s. The filtrate was collected for LC-MS/MS analysis. Quality control (QC) samples were prepared by pooling equal aliquots of the supernatant from all experimental samples.</p>"],"organism":["Mus musculus"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS14735"],"author":["Chen Kunzhui. Guangzhou University. kz_chen@e.gzhu.edu.cn."],"data_transformation_protocol":["<p>Raw LC-MS/MS data were converted to mzXML format using ProteoWizard software version 3.0.24054. The converted files were processed using an in-house R-based workflow for peak detection, feature extraction, alignment and integration. Data preprocessing included outlier filtering based on relative standard deviation, missing value filtering, missing value imputation using half of the minimum value, and normalization using the total ion current. The processed data matrix was used for downstream statistical and multivariate analyses.</p>"],"study_factor":["Treatment"],"submitter_email":["kz_chen@e.gzhu.edu.cn"],"sample_collection_protocol":["<p>Mouse liver samples were collected for untargeted metabolomics analysis. The submitted samples included three experimental groups: CON, MOD and PCE-H, with six biological replicates per group, for a total of 18 liver samples. After collection, all samples were immediately stored at -80 °C until metabolomics analysis.</p>"],"omics_type":["Metabolomics"],"study_design":["ProteoWizard msconvert","Metabolomics","LC-MS","Mus musculus","Orbitrap Exploris 120 mass spectrometer (Thermo Fisher Scientific)","liver","untargeted analysis","alcoholic fatty liver disease","experimental blank","Vanquish UHPLC system (Thermo Fisher Scientific)"],"curator_keywords":["ProteoWizard msconvert","Metabolomics","LC-MS","Mus musculus","alcoholic fatty liver disease","Orbitrap Exploris 120 mass spectrometer (Thermo Fisher Scientific)","liver","untargeted analysis","experimental blank","Vanquish UHPLC system (Thermo Fisher Scientific)"],"mass_spectrometry_protocol":["<p>Mass spectrometry was performed using an Orbitrap Exploris 120 mass spectrometer (Thermo Fisher Scientific) controlled by Xcalibur software version 4.4. MS and MS/MS data were acquired in electrospray ionization (ESI) mode using both positive and negative ion modes. The scan m/z range was 70-1200. The ESI source parameters were set as follows: sheath gas flow rate, 50 Arb; auxiliary gas flow rate, 15 Arb; capillary temperature, 320 °C; full MS resolution, 60000; MS/MS resolution, 15000; collision energy, SNCE 20/30/40. The spray voltage was 3.8 kV in positive ion mode and -3.4 kV in negative ion mode.</p>"],"metabolite_name":["Thr-Phe","Acamprosate (calcium)","Peonidin 3-O-rutinoside cation","2'-O-Methyluridine","8-Oxononanoic acid","Deoxyinosine","myricetin","Val-Met","Nolatrexed","2-Ketocaproic acid","Thiolutin","Ketoleucine","Hexanoylglycine",".beta.-Tocotrienol","Cholest-4-en-26-oic acid, 7alpha-hydroxy-3-oxo","Dimethyl hydrogen phosphate","Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-","Resveratrol 4'-O-D-glucuronide","Citrulline","Carprofen","Glycolate","4,4'-Sulfonylbisphenol","Capric acid","coniferin","Isomalt","Octadecanedioic acid","1-Hydroxy-2-naphthoic acid","2-Acetamido-3-(4-hydroxy-3-methoxyphenyl)propanoic acid","4-Hydroxybenzaldehyde","Tolfenamic acid","Arabinono-1,4-lactone","lactitol","Glu-Arg","Oleic acid","Cystathionine","Ala-Phe","4-Hydroxyglutamic acid","Adenylsuccinic acid","N-Acetylglutamic acid","Chrysoeriol","2-Ketogluconic acid","Gallic_acid","Terephthalic-Acid","2-Methylglutaric acid","His-Val","3-[1,1-bis(4-hydroxyphenyl)-3-oxo-3-(2,4,6-trihydroxyphenyl)propan-2-yl]-5,7-dihydroxychromen-4-one","N6-Methyladenine","2-Hydroxypalmitic acid","Nitrotyrosine","Pyridoxal (Vitamin B6)","N-Acetylneuraminic acid","Pantothenic acid","(S)-3,4-Dihydroxybutyric acid (lithium hydrate)","Anthranilic acid (Vitamin L1)","Aceritannin","5,6-Dihydroxyindole","Tyrosylalanine","Isovaleric acid","Ribothymidine","3-Hydroxydecanoic acid","Leu-Val","Taurohyodeoxycholic acid","Erucic acid","3-Oxocholic acid","Acetylglycine","HEPTANOIC ACID","Glyceric acid","(-)-Epigallocatechin gallate","Euscaphic acid","Phe-Glu","Imatinib","2-amino-3-({[3-(hexadecanoyloxy)-2-(octadecanoyloxy)propoxy](hydroxy)phosphoryl}oxy)propanoic acid","Phthalic acid","Lys-Ile","Flavanone base + 5O","2-Arachidonoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine","Prolylalanine","Chlorothalonil-4-hydroxy","Linoleoylglycine","N-Oleoyl glycine","Benzenesulfonamide, 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-","13,14-Dihydro-15-keto-PGE2","2-Phenyllactic acid","Pyrophosphate","Bendroflumethiazide","2-amino-3-({hydroxy[2-(icosanoyloxy)-3-[octadec-11-enoyloxy]propoxy]phosphoryl}oxy)propanoic acid","Methylacetate","4-Acetamidobutyric acid","4-Hydroxyphenylacetaldehyde","Malonic acid","(6E)-8-Methyl-6-nonenoic acid","Proline","cis-11.14-Eicosadienoic acid","risedronate","Isopentenyladenine","Isoxanthopterin","3,7-Dimethyluric acid","Isocitric acid","Plumbagin","3-Hydroxypropionic acid (beta-lactic acid)","Tyr-Gly","3-Hydroxyphenylaceitic acid sulfate",".alpha.,.alpha.'-Trehalose 6-phosphate","Tetradecyl sulfate (sodium)","4'-Hydroxy-3'-methylacetophenone","N-Lauroylglycine","Gly-His","TRICARBALLYLIC ACID","Soyasapogenol B base + O-HexA-Hex-Pen, O-C6H7O3(DDMP)","Glucuronic acid","Prostaglandin F2alpha (PGF2a)","Pro-Ile","2,4-Dihydroxybutanoic acid","Linoleic acid","Homogentisic acid","Fumaric acid","Adenosine 3',5'-diphosphate (PAP)","Triamcinolone","Thelephoric acid","N-3,4-Tridhydroxybenzamide","3-Hydroxybutyric acid","Lithocholic acid 3-sulfate","2-Amino-3-(1H-pyrazol-1-yl)propanoic acid","Phenylpyruvic acid","Benzoic acid","Sucrose","Stearidonic acid","Melilotoside","beta-Cyano-alanine","Glucose","Tetradecanedioic acid","Dodecyl gallate","Thr-Ser","Glycylproline","O-Acetylserine","GLUCOSAMINE 6-SULFATE","6-Formylpterin","1,2-Distearoyl-sn-glycero-3-phospho-L-serine","gamma-Glutamylleucine","7-Hydroxy-4-(trifluoromethyl)coumarin","Cephamycin C","2-Ketobutyric acid","Isodeoxycholic acid","Roflumilast","3-METHYLGLUTACONIC ACID","Valeric acid","Nitrofurazone","4-Aminobenzoic acid","Butyllactate","3-Aminohexanoic acid","N-(4-Chlorobenzoyl)tryptophan","4-Nitroaniline","N-Acetylglucosamine","2-Methylbutyrylglycine","Suberic acid","(2E)-4-Hydroxybut-2-enoic acid","Acetylsalicylic acid","Aminomalonic acid","Trihydroxycholestanoic acid","Oxacillin","Hydroxyacetone","2-[[7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-3-(hydroxymethyl)-6,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl]methoxy]oxane-3,4,5-triol","1,5-Anhydro-2-O-(6-deoxyhexopyranosyl)-1-(5,7-dihydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-8-yl)hexitol","N-Acetylphenylalanine","Cytidine 5'-monophosphate (CMP)","[2.3-dihydroxypropoxy][2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-[octadec-9-enoyloxy]propoxy]phosphinic acid","2-Hydroxyoctanoic acid","Glu-Val","Xanthosine","2-Docosahexaenoyl-1-stearoyl-sn-glycero-3-phosphoethanolamine","2,2-Dimethylsuccinic acid","3-Methyl-2-oxovaleric acid","Pimelic acid","Desaminotyrosine","cis-7-Hexadecenoic acid","Citric acid","Mannose 1-phosphate","Glycylleucine","cis-9-Palmitoleic acid","5-Aminopentanoic acid","Valine","Denticetic-acid","Propyzamide","Hydroxyisocaproic acid","Glutathione disulfide","2-Oxoglutarate","cis-​9,​10-​Epoxystearic acid","(2-aminoethoxy)[2-[icosa-5.8.11.14-tetraenoyloxy]-3-[octadec-11-enoyloxy]propoxy]phosphinic acid","2-(HYDROXYMETHYL)BUTANOIC ACID","Tauroursodeoxycholic acid","S-(2-Carboxypropyl)glutathione","9-Oxo-10(E),12(E)-octadecadienoic acid","Glu-Asp","Allyl_isothiocyanate","Glycocholic acid","Phe-Val","Pipecolic acid","Leu-Leu","Glucose 6-phosphate","2'-Deoxyuridine","(2-aminoethoxy)[2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-[hexadec-1-en-1-yloxy]propoxy]phosphinic acid","Stearic acid","1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-myo-inositol)","6-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one","Warfarin","Ethyl 4-hydroxybenzoate","Nitrilotriacetic acid","Indapamide","Uridine diphosphate glucose (UDP-glucose)","2-Hydroxy-3-methylbutyric acid","Ala-Asp","Glutamate","Succinic_anhydride","Glu-Asn","DL-Isocitric acid lactone","Mangiferin","Morphine-3-glucuronide","Diacetylrhein","LPE(14:0)","2-Aminoadipic acid","N-(4-Aminobenzoyl)-L-glutamic acid","N-Stearoyltaurine","Genistein","3-Hydroxyisovaleric acid","Alanylalanine (Ala-Ala)","Dodecanoic acid","Glyoxylic acid","b-Ala-Lys","3.alpha.,7.alpha.-Dihydroxy-12-oxocholanoic acid","Gly-Ser","2-Hydroxyethanesulfonic acid","7-Ketolithocholic acid","Thymine","3-Oxopentanoic acid","Clofarabine","Pelargonic acid","2-Hydroxyglutaric acid","13(S)-HODE","Hyodeoxycholic acid","N-Acetylglucosamine 1-phosphate","4-Hydroxyisoleucine","4-Hydroxyphenylacetic acid","Pentachlorophenol","Galactose","N-Acetylalanine","16-Hydroxypalmitic acid","Rufloxacin","Taurine","N-Acetylgalactosamine","N-Acetyl-2-carboxybenzenesulfonamide","Embelin","Allantoin","3,4-Dihydroxyphenylacetic acid","1,5-Anhydroglucitol","Ala-Val","LPG(18:1(9Z))","Probucol","Riluzole","Mannose 6-phosphate","Maltobionate",".beta.-D-Glucopyranosiduronic acid, 4-(7-hydroxy-4-oxo-4H-1-benzopyran-3-yl)phenyl","D-Saccharic acid 1,4-lactone","Methotrexate_hydrate","Trifluoroacetic acid","5-Hydroxyvalproic acid","Taxifolin","beta-Alanine","Kynurenic acid","2,3-Dihydroxy-2-methylbutanoic acid","Carbamoyl_phosphate","Carboxytolbutamide","alpha-Ketoisovaleric acid","Cholic acid 7-sulfate","(2-aminoethoxy)[3-[hexadec-1-en-1-yloxy]-2-[icosa-5.8.11.14-tetraenoyloxy]propoxy]phosphinic acid","Flavonol base + 4O, O-MalonylHex","N-Fluorenylacetamide","Thymidine_3,5-cyclic_monophosphate","trans-Vaccenic acid","cis-11-Eicosenoic acid","4-Hydroxyproline","Cholesteryl sulfate","CROTONIC ACID","Xanthotoxin","Ethyl glucuronide","Carnosine","Fructose 1-phosphate","N-Acetylglutamine","Pyrazosulfuron-ethyl","3-Hydroxyvaleric acid","N-Formylglycine","gamma-Glutamylglutamic acid","Val-Ile","Vigabatrin","Phosphate","Paclitaxel","3-Methylcrotonylglycine","PI(18:1/18:1)","Axillarin 4'-glucuronide","3-Methyladipic acid","Pentadecanoic acid","3-[[4-(4-Chlorophenyl)piperazino]methyl]-1H-pyrrolo[2,3-b]pyridine","3-Hydroxy-6H-benzo[c]chromen-6-one","Phenylalanine","Phenylacetylglycine","17-ODYA","Pyrogallol","3-Phenylpropanoic acid","Phe-Leu","Uracil","Eicosapentaenoic acid","Glu-Glu","Rhein","1,7-Dimethyluric acid","11-Dehydrocorticosterone","epicatechin gallate","Creatine","5-Aminolevulinic acid","5-Iodo-2'-deoxyuridine","3-Methyluridine","beta-Muricholic acid","5-(4-Hydroxyphenyl)-5-phenylhydantoin","Ile-Leu","3-Ureidopropionic acid","2-[2-(2-Methoxyethoxy)ethoxy]acetic acid","12-Methyltridecanoic acid","3alpha-Hydroxy-12-oxo-5beta-cholan-24-oic acid","3-Hydroxylauric acid","Oxalic acid","Myristic acid","6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid","2,4-Dinitrophenol","Adipic acid","O,O-Dimethyl dithiophosphate","Dephospho-CoA","D-Ribose 1-phosphate","Homoserine","2'-Deoxyguanosine 5'-diphosphate (dGDP)","gamma-Linolenic acid","3-Methylthiopropionic acid","alpha-Linolenic acid","Pivagabine","Uridine 5'-monophosphate (UMP)","1-Palmitoyllysophosphatidate","beta-Guanidinopropionic acid","Val-Val","Phe-Asp","(2S)-4-amino-2-[(azaniumylacetyl)amino]-4-oxobutanoate","Gln-Thr","N-Palmitoyl-D-erythro-dihydroceramide-1-phosphate","Gly-Ala","UDP-N-acetylglucosamine","2-Hydroxybutyric acid","8-Oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl hexopyranoside","2-Methyl-3-hydroxybutyric acid","Phe-Tyr","2-Ethyl-2-hydroxybutyric acid","Arachidonic acid (AA)","2'-Hydroxy-5'-methylacetophenone","2-Methylhippuric acid","Pyruvate","Threonic acid","2,2'-Iminodiacetic acid","N-Octanoylglycine","HEPES","Heptadecanoic acid","Doxycycline","Citraconic acid","Rifaximin","2-Arachidonoyl-1-stearoyl-sn-glycero-3-phosphoethanolamine","Dimethylglycine","Lumichrome","3-Hydroxyphenylacetic acid","Methylimidazoleacetic acid","TIGLIC ACID","Phenylacetic acid","5,10-methylene-THF","Caproic acid","1,6-Anhydro-.beta.-D-glucose","N-Acetyl-asparagine","Methylenediphosphonic acid","Dihydroxyacetone phosphate","Palmitoylglycine","Palmitic acid","Procyanidin B1","1,2-Dilinolenoyl-sn-glycero-3-phosphoethanolamine","sn-Glycerol 3-phosphate","Ala-Gly","N-Acetylmethionine","Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-","Perillic_acid","GDP-fucose","Lys-Gln","Acetylleucine","Propionic acid","Allopurinol-1-ribonucleoside","Allocholic acid","Dexrazoxane","12-Hydroxydodecanoic acid","Glyco-beta-muricholic acid","Gly-Val","N5-acetyl-l-ornithine","Docosahexaenoic acid (DHA)","2-Hydroxystearic acid","Isobutyric_acid","Methyl β-D-glucopyranoside","Nicotinamide","Threitol","Theophylline","7-Ketodeoxycholic acid","3-Methylglutaric acid","Propofol .beta.-D-glucuronide","Formylmethionine","Picolinic acid","Thr-Leu","myo-Inositol","Sorbose","Pyroglutamic acid","3-Hydroxyoctanoic acid","N-Methylglutamic acid","Hydroxyphenyllactic acid","N-Lactoylphenylalanine","2-Methylguanosine","gamma-Glutamylglutamine","N-Acetylhistidine","Levulinic acid","Isomaltose","Ginsenoside F3","PG(18:1/18:1(9Z))","Deoxyguanosine","His-Leu","Asparagine","2-Anilinopropanoic acid","Tauro-beta-muricholic acid","Leucylphenylalanine","24-epi-brassinolide","Lactate","Glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)-",".beta.-Hydroxyphenylalanine","Thymidine","2-Hydroxyhexanoic acid","Ursodeoxycholic acid","Isocaproic acid","Val-Ser","Pantetheine","Orotic acid","Paprazine","2,4-dinitrotoluene","3-Hydroxypyruvic acid","Malic acid","Flavin adenine dinucleotide (FAD)","3-Phosphoglyceric acid","Docebenone","2-Aminopurine","1,3-Thiazolidine-4-carboxylic acid","3-Amino-4-methylpentanoic acid","Fenoterol","Cytidine 2',3'-cyclic phosphate","Maltose","Bufalin","Ticlopidine","Tetracycline","N-Acetyltyrosine","2-Hydroxy-2-methylbutyric acid","3,12-dihydroxy-4,6a,6b,11,12,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,11,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylic acid","2-Hydroxymyristic_Acid","Oxypurinol","Resolvin_D2","Pyruvaldehyde","Gulono-1,4-lactone","Azathioprine","12-Hydroxystearic acid","5-Hydroxyoxindole","Diglycine","Gly-Asp","Isovalerylglycine","2-Oxoadipic acid","3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid","Methionine sulfoxide","Taurodeoxycholic acid","Maltoheptaose","4-Aminobutyric acid (GABA)","Azelaic acid","Lorazepam glucuronide","Epinephrine","2-Hydroxyhexanedioic acid","Primuletin","D-RIBOSE","Dethiobiotin","Vesnarinone","2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine","Deoxycholic acid","2'-Deoxyguanosine 5'-monophosphate (dGMP)","1,7-Dimethylxanthine"],"additional_accession":[]},"is_claimable":false,"name":"Penthorum chinense Pursh Ameliorates Metabolic Dysfunction-Associated Alcohol-Related Liver Disease through Gut Microbiota Modulation and Metabolic Remodeling","description":"Metabolic dysfunction-associated alcohol-related liver disease (MetALD) is characterized by hepatic steatosis, oxidative stress, inflammation, and gut microbiota dysbiosis resulting from the coexistence of metabolic dysfunction and alcohol consumption. Penthorum chinense Pursh is a traditional edible medicinal plant rich in polyphenols; however, its role in MetALD remains unclear. In this study, a polyphenol-rich Penthorum chinense extract (PCE) was characterized by UPLC–TOF/MS, with gallic acid and pinocembrin identified as major constituents. The protective effects of PCE were evaluated in a mouse model of MetALD induced by a high-fat diet combined with ethanol exposure. PCE administration markedly alleviated hepatic steatosis and liver injury, reduced inflammatory cytokine levels, and improved antioxidant status. Moreover, PCE partially normalized the expression of genes associated with lipid metabolism and inflammation, including Srebp-1c, Pparα, and Nfkb1. 16S rRNA sequencing revealed that PCE partially restored gut microbial dysbiosis, characterized by increased abundances of Dubosiella and Ligilactobacillus. Untargeted metabolomics further demonstrated significant alterations in hepatic metabolic profiles, particularly in pathways related to amino acid metabolism and energy metabolism. Correlation analysis revealed significant associations between differential gut microbial taxa and hepatic metabolites. These findings suggest that PCE ameliorates MetALD by improving hepatic metabolic homeostasis, oxidative stress, inflammation, and gut microbiota composition. This study provides experimental evidence supporting the potential application of Penthorum chinense as a functional food resource for the prevention and management of metabolic liver disorders.","dates":{"publication":"2026-06-10","submission":"2026-06-10"},"accession":"MTBLS14735","cross_references":{"HMDB":["HMDB0011179","HMDB0000619","HMDB0000897","HMDB0028932","HMDB0000951","HMDB0001372","HMDB0000194","HMDB0004620","HMDB0011178","HMDB0003464","HMDB0000452","HMDB0000133","HMDB0029120","HMDB0029134","HMDB0000296","HMDB0001173","HMDB0001906","HMDB0000123","HMDB0000271","HMDB0062203","HMDB0000660","HMDB0029139","HMDB0000034","HMDB0002730","HMDB0243946","HMDB0000036","HMDB0000048","HMDB0002666","HMDB0000045","HMDB0000939","HMDB0000875","HMDB0028922","HMDB0000195","HMDB0028988","HMDB0006038","HMDB0000050","HMDB0003331","HMDB0004044","HMDB0000252","HMDB0011177","HMDB0000172","HMDB0001185","HMDB0000182","HMDB0001397","HMDB0003540","HMDB0000128","HMDB0028716","HMDB0000965","HMDB0031641","HMDB0000468","HMDB0001488","HMDB0242132","HMDB0000562","HMDB0251526","HMDB0304396","HMDB0000670","HMDB0001586","HMDB0000161","HMDB0000158","HMDB0000043","HMDB0030396","HMDB0001129","HMDB0028691","HMDB0000292","HMDB0000848","HMDB0012273","HMDB0000301","HMDB0060665","HMDB0003971","HMDB0001262","HMDB0006695","HMDB0000062","HMDB0003045","HMDB0240650","HMDB0033951","HMDB0004827","HMDB0000089","HMDB0004610","HMDB0004193","HMDB0000187","HMDB0000214","HMDB0001341","HMDB0001520","HMDB0059660","HMDB0000086","HMDB0002024","HMDB0061694","HMDB0000132","HMDB0000157","HMDB0008097","HMDB0000269","HMDB0029217","HMDB0013078","HMDB0250707","HMDB0028702","HMDB0000001","HMDB0000167","HMDB0000206","HMDB0029000","HMDB0061880","HMDB0003584","HMDB0061822","HMDB0256387","HMDB0004194","HMDB0001413","HMDB0000824","HMDB0002013","HMDB0000244","HMDB0256256","HMDB0015695","HMDB0004949","HMDB0001563","HMDB0000736","HMDB0000902","HMDB0000055","HMDB0000552","HMDB0000982","HMDB0013128","HMDB0062179","HMDB0029006","HMDB0007982","HMDB0246162","HMDB0004231","HMDB0094708","HMDB0002088","HMDB0000975","HMDB0013130","HMDB0000235","HMDB0015101","HMDB0000446","HMDB0000191","HMDB0094696","HMDB0003269","HMDB0032538","HMDB0001335","HMDB0001852","HMDB0000688","HMDB0000854","HMDB0028885","HMDB0013127","HMDB0000756","HMDB0011506","HMDB0010390","HMDB0000323","HMDB0006455","HMDB0001538","HMDB0000097","HMDB0013337","HMDB0006709","HMDB0062175","HMDB0002038","HMDB0003157","HMDB0000898","HMDB0000259","HMDB0007972","HMDB0000501","HMDB0013287","HMDB0000517","HMDB0001539","HMDB0010382","HMDB0000865","HMDB0014581","HMDB0062769","HMDB0000641","HMDB0010379","HMDB0061680","HMDB0010407","HMDB0001250","HMDB0029615","HMDB0000855","HMDB0000819","HMDB0012108","HMDB0010386","HMDB0007869","HMDB0005066","HMDB0000177","HMDB0061712","HMDB0059712","HMDB0240288","HMDB0001276","HMDB0000630","HMDB0000039","HMDB0001325","HMDB0001257","HMDB0000699","HMDB0243890","HMDB0062559","HMDB0003282","HMDB0259112","HMDB0000593","HMDB0011600","HMDB0000037","HMDB0000295","HMDB0028840","HMDB0257211","HMDB0000403","HMDB0061933","HMDB0010715","HMDB0301753","HMDB0002894","HMDB0003243","HMDB0001565","HMDB0060741","HMDB0038804","HMDB0015004","HMDB0251529","HMDB0010384","HMDB0008994","HMDB0000222","HMDB0000079","HMDB0247518","HMDB0062656","HMDB0014984","HMDB0006050","HMDB0060768","HMDB0244070","HMDB0041895","HMDB0014610","HMDB0007881","HMDB0255165","HMDB0062766","HMDB0012253","HMDB0028884","HMDB0029412","HMDB0015575","HMDB0028995","HMDB0029004","HMDB0244929","HMDB0009093","HMDB0008946","HMDB0011253","HMDB0244231","HMDB0014334","HMDB0341362","HMDB0244288","HMDB0015344","HMDB0244990","HMDB0004304","HMDB0002169","HMDB0256554","HMDB0029127","HMDB0031612","HMDB0341238","HMDB0256296","HMDB0060374","HMDB0002032","HMDB0000802","HMDB0008727","HMDB0259297","HMDB0254880","HMDB0243891","HMDB0029586","HMDB0011262","HMDB0029005","HMDB0245482","HMDB0014682","HMDB0302157","HMDB0011730","HMDB0011740","HMDB0036139","HMDB0254597","HMDB0001939","HMDB0001296","HMDB0240261","HMDB0240606","HMDB0011503","HMDB0003831","HMDB0254733","HMDB0032985","HMDB0028895","HMDB0028888","HMDB0029039","HMDB0038288","HMDB0028989","HMDB0002144","HMDB0011174","HMDB0029001","HMDB0242151","HMDB0243828","HMDB0008002","HMDB0039528","HMDB0008748","HMDB0256501","HMDB0061716","HMDB0038856","HMDB0034301","HMDB0015334","HMDB0029533","HMDB0030660","HMDB0094680","HMDB0032358","HMDB0014924","HMDB0033247","HMDB0028893","HMDB0028894","HMDB0028878","HMDB0028993","HMDB0042006","HMDB0031547","HMDB0002141","HMDB0246870","HMDB0253663","HMDB0246408","HMDB0008206","HMDB0245944","HMDB0248993","HMDB0034198","HMDB0002227","HMDB0001555","HMDB0241541","HMDB0242112","HMDB0001564","HMDB0028946","HMDB0029048","HMDB0094692","HMDB0028940","HMDB0002104","HMDB0030352","HMDB0256963","HMDB0013409","HMDB0252008","HMDB0244804","HMDB0036623","HMDB0061690","HMDB0013161","HMDB0036361","HMDB0252828","HMDB0341191","HMDB0005768","HMDB0008100","HMDB0036394","HMDB0028955","HMDB0245160","HMDB0038321","HMDB0015573","HMDB0028715","HMDB0258294","HMDB0029795","HMDB0014875","HMDB0030177","HMDB0030776","HMDB0011152","HMDB0002815","HMDB0241684","HMDB0253644","HMDB0030391","HMDB0011149","HMDB0010398",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