***Cases that share raw files were mounted and scanned on the same slide. Please reach out to sprokop@ufl.edu or jvillareal@ufl.edu for the .tiff files showing the spatial arrangement of each tissue sample on the slide for these cases.***
Please refer to the following citation for the complete protocol: Hawkinson, T.R., and Sun, R.C. (2022). Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of GlycogenGlycogen In Situ. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, Y.-J. Lee, ed. (Springer US), pp. 215–228. https://doi.org/10.1007/978-1-0716-2030-4_15.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["MS Imaging - positive"],"publication":["Corpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains."],"submitter_affiliation":["University of Florida"],"submitter_name":["Jonathan Villareal"],"organism_part":["brain"],"technology_type":["mass spectrometry assay"],"disease":[""],"organism":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS14754"],"author":["Stefan Prokop. University of Florida. sprokop@ufl.edu.","Jonathan Villareal. University of Florida. jvillareal@ufl.edu."],"data_transformation_protocol":["***Cases that share raw files were mounted and scanned on the same slide. Please reach out to sprokop@ufl.edu or jvillareal@ufl.edu for the .tiff files showing the spatial arrangement of each tissue sample on the slide for these cases.***
Please refer to the following citation for the complete protocol: Hawkinson, T.R., and Sun, R.C. (2022). Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of GlycogenGlycogen In Situ. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, Y.-J. Lee, ed. (Springer US), pp. 215–228. https://doi.org/10.1007/978-1-0716-2030-4_15.
"],"study_factor":["ADNC stage","Brain region"],"submitter_email":["jvillareal@ufl.edu"],"sample_collection_protocol":["***Cases that share raw files were mounted and scanned on the same slide. Please reach out to sprokop@ufl.edu or jvillareal@ufl.edu for the .tiff files showing the spatial arrangement of each tissue sample on the slide for these cases.***
Please refer to the following citation for the complete protocol: Hawkinson, T.R., and Sun, R.C. (2022). Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of GlycogenGlycogen In Situ. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, Y.-J. Lee, ed. (Springer US), pp. 215–228. https://doi.org/10.1007/978-1-0716-2030-4_15.
"],"omics_type":["Metabolomics"],"histology_protocol":["***Cases that share raw files were mounted and scanned on the same slide. Please reach out to sprokop@ufl.edu or jvillareal@ufl.edu for the .tiff files showing the spatial arrangement of each tissue sample on the slide for these cases.***
Please refer to the following citation for the complete protocol: Hawkinson, T.R., and Sun, R.C. (2022). Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of GlycogenGlycogen In Situ. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, Y.-J. Lee, ed. (Springer US), pp. 215–228. https://doi.org/10.1007/978-1-0716-2030-4_15.
"],"preparation_protocol":["***Cases that share raw files were mounted and scanned on the same slide. Please reach out to sprokop@ufl.edu or jvillareal@ufl.edu for the .tiff files showing the spatial arrangement of each tissue sample on the slide for these cases.***
Please refer to the following citation for the complete protocol: Hawkinson, T.R., and Sun, R.C. (2022). Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of GlycogenGlycogen In Situ. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, Y.-J. Lee, ed. (Springer US), pp. 215–228. https://doi.org/10.1007/978-1-0716-2030-4_15.
"],"study_design":["Metabolomics","Alzheimer disease","FORMALIN-FIXED","untargeted analysis","Synapt XS MALDI-MSI","Homo sapiens","glycogen","MALDI-MSI","brain","Waters"],"curator_keywords":["Metabolomics","Alzheimer disease","FORMALIN-FIXED","untargeted analysis","Synapt XS MALDI-MSI","Homo sapiens","glycogen","MALDI-MSI","brain","Waters"],"mass_spectrometry_protocol":["***Cases that share raw files were mounted and scanned on the same slide. Please reach out to sprokop@ufl.edu or jvillareal@ufl.edu for the .tiff files showing the spatial arrangement of each tissue sample on the slide for these cases.***
Please refer to the following citation for the complete protocol: Hawkinson, T.R., and Sun, R.C. (2022). Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of GlycogenGlycogen In Situ. In Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, Y.-J. Lee, ed. (Springer US), pp. 215–228. https://doi.org/10.1007/978-1-0716-2030-4_15.
"],"additional_accession":[]},"is_claimable":false,"name":"Corpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains (MS (MTBLS))","description":"Increasing evidence indicates that shifts in brain polysaccharide metabolism can influence the progression of multiple neurodegenerative diseases. Here we perform MALDI-MSI analysis of glycogen at different chain lengths in patients at different stages of Alzheimer's Disease. We look at frontal cortex, occipital cortex, and hippocampus grey and white matter and provide the raw files containing relative abundance of glycogen for each of these regions and patients.
","dates":{"publication":"2026-06-12","submission":"2026-06-12"},"accession":"MTBLS14754","cross_references":{}}