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The metabolites were identified by the HMDB (http://www.hmdb.ca/), Metlin (https://metlin.scripps.edu/) and Majorbio databases. The data matrix obtained by searching the database was uploaded to the Majorbio cloud platform (https://cloud.majorbio.com) for data analysis. At least 80% of the metabolic features detected in any set of samples were retained. After filtering, for specific samples whose metabolite levels were below the lower limit of quantification, the minimum metabolite value was estimated, and each metabolic signature was normalized to the sum. The response intensities of the sample mass spectrometry peaks were normalized using the sum normalization method. Moreover, the variables of the QC samples whose relative standard deviation was > 30% were excluded and converted to log10 to obtain the final data matrix for subsequent analysis.</p>MetaboLightsPublicLiquid Chromatography MS - alternating - reverse-phase<p>Analysis was conducted on a ABSCIEX UHPLC-Triple TOF system equipped with an ACQUITY HSS T3 column (100 mm × 2.1 mm i.d., 1.8 μm; Waters, USA) at Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China). The mobile phases consisted of 0.1% formic acid in water:acetonitrile (95:5, v/v) (solvent A) and 0.1% formic acid in acetonitrile:isopropanol:water (47.5:47.5, v/v) (solvent B). The flow rate was 0.40 mL/min, and the column temperature was 45°C.</p>An integrated multiomic single-vesicle atlas delineates graft exosome heterogeneity in chronic lung allograft dysfunction. 10.1038/s41392-026-02927-7.Xiangyun ZhengLung Transplant Research Laboratory, West China Hospital, Sichuan UniversityLungmass spectrometry assay<p>A total of 50 mg of the same anatomical region of the lung graft was added to a 2 mL centrifuge tube, and 6 mm diameter grinding beads were added. Metabolites were extracted using 400 L of extraction solution (methanol:water = 4:1 (v:v)) containing 0.02 mg/mL of an internal standard (L-2-chlorophenylalanine). A frozen tissue grinder was used to grind the samples for 6 min (-10°C, 50 Hz), followed by ultrasonic extraction for 30 min (5°C, 40 kHz). After being frozen at -20°C for half an hour, the samples were spun at 13000 × g for 15 min at 4°C, and the resulting liquid was moved to the injection vial. Quality control (QC) samples are prepared by pooling equal volumes of the extracts from all study samples. Each QC sample is of the same volume as the test samples and is processed and detected using the same methods as the analytical samples. During instrumental analysis, a QC sample is inserted after every 5 to 15 analytical samples to monitor the stability of the overall analytical process.</p>Rattus norvegicushttps://www.ebi.ac.uk/metabolights/MTBLS14797Dong Tian. West China Hospital of Sichuan University. 22tiandong@163.com.Xiangyun Zheng. West China Hospital of Sichuan University. zhengxiangyun01@163.com.<p>The raw data were processed in Progenesis QI for peak detection and alignment, which resulted in m/z values and peak intensity information. Accurate masses were used to identify the mass spectra of metabolic features. The pretreatment of the LC/MS raw data was performed with Progenesis QI (Waters Corporation, Milford, USA) software.</p>Chronic rejectionzhengxiangyun01@163.com<p>Male Lewis and Brown Norway rats were purchased from were purchased from SiPeiFu Biotechnology (Beijing, China). All the rats were specific-pathogen-free inbred males weighing 250–300 g (10–12 weeks old) and were kept on a 12–hour light–dark cycle with free access to food and water. Orthotopic left LTx was performed in rats as previously described. A CR rat model were established on the basis of previously published methods. Briefly, LTx (Brown Norway to Brown Norway) was performed in the Syn group, whereas MHC-mismatched LTx (Brown Norway to Lewis) was performed in the CR rat model groups. After LTx, all the rats were treated with CsA three times weekly at posttransplant week 1. All the rats were sacrificed at the end of posttransplant week 4. A total of 50 mg of the same anatomical region of the lung graft (Syn group, N = 3; CR group, N = 9) was further performed.</p>Metabolomicspooled quality control sampleMetabolomicschronic lung allograft dysfunctionABSCIEX UHPLC-Triple TOF systemLung transplant rejectionuntargeted analysisLungRattus norvegicusChronic rejection of lung transplantexperimental samplepooled quality control sampleMetabolomicschronic lung allograft dysfunctionABSCIEX UHPLC-Triple TOF systemLung transplant rejectionuntargeted analysisLungRattus norvegicusChronic rejection of lung transplantexperimental sample<p>Mass spectrometry analysis was conducted using a ABSCIEX UHPLC-Triple TOF system. Mass Spectrometer equipped with an electrospray ionization (ESI) source operating in positive mode and negative mode. The optimal conditions were set as followed: source temperature at 500℃ ; ion-spray voltage floating (ISVF) at -4500V in negative mode and 5500V in positive mode, respectively; Normalized collision energy , 40±20 rolling for MS/MS. Data acquisition utilized the data-dependent acquisition mode, with detection spanning a mass range of 50–1200 m/z.</p>(2S,3S,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-2-(2,2-dimethylmorpholino)-3-hydroxy-10,13-dimethylhexadecahydro-11H-cyclopenta[a]phenanthren-11-one(2S)-N-[(2S)-1-[(2-Amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide1-Nonadecanoyl-glycero-3-phosphoethanolamine1-Linoleoyl-sn-Glycero-3-Phosphocholine9,10-DHOME7-[(1R,2R,5S)-5-Hydroxy-2-[(1E,3S)-3-Hydroxyoct-1-en-1-yl]-3-oxocyclopentyl]heptanoylcarnitine2-MethylpropanalXestoaminol CCarboxydextranSchidigeragenin BFloratheasaponin FVitamin D3 glucosiduronateLumirubin6alpha,9alpha-Difluoroprednisolone-17-butyrateN-di-Demethyl roxithromycinN-Stearoyl ProlinePE(22:5(4Z,7Z,10Z,13Z,16Z)/22:2(13Z,16Z))L-HistidinePro Arg GlyGabazine(2S,3R,4R)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acidDiosgenin 3-[glucosyl-(1->6)-glucosyl-(1->4)-rhamnosyl-(1->4)[rhamnosyl-(1->2)]-glucoside]PE(P-16:0/18:2(9Z,12Z))PC(16:0/0:0)Cytidine 5'-monophosphate-N-acetylneuraminic acidAlpha-Hydroxy-N-desmethyltamoxifenCarboprost3-ethylphenyl SulfateSelancPC(P-18:0/18:1(12Z)-2OH(9,10))TanabalinLysoPC(O-18:0/0:0)NocloprostUbiquinol-7(-)-DeoxypodophyllotoxinPhe-Pro-IleL-Pipecolic acid2',3,4',5-Tetrahydroxy-4-prenylstilbene3',5'-Cyclic GMP4b-HydroxystanozololHovenolactonePC(20:4(5Z,8Z,11Z,14Z)-OH(19S)/24:1(15Z))Abscisic alcohol3-Hydroxy-11Z-octadecenoylcarnitine2-(3-Carboxy-3-(methylammonio)propyl)-L-histidineArginylglutamineAlpha-Ionol O-[arabinosyl-(1->6)-glucoside]54-DeoxyciguatoxinGamma-GlutamyltyrosineDG(20:4(5Z,8Z,11Z,14Z)/16:1(9Z)/0:0)ButaprostHistidyllysineN-Eicosapentaenoyl Serine11-cis-RetinaldehydeRacematesDG(18:0/18:2(9Z,12Z)/0:0)3a,12b-Dihydroxy-5b-cholanoic acidPE(15:0/16:0)CarotolArtemorinGamabufotalinMG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0)OleamidePG(20:4(8Z,11Z,14Z,17Z)-2OH(5S,6R)/i-12:0)1-Cyclohexene-1-carboxylic acidHordatine A glucosideBursopoietinBis(p-methylbenzylidene)sorbitol1-StearoylglycerophosphoglycerolPG(LTE4/i-20:0)SalicylaldehydeUrsocholic acidP-Tolyl Sulfate10-EdAMN-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl esterGlycinoeclepin CAraloside AMG(20:1(11Z)/0:0/0:0)4-Hydroxyestrone-2-S-glutathioneKanamycinPI(20:0/PGF2alpha)Crocin 4PS(20:0/20:2(11Z,14Z))N-(3-{1-[4-(3,4-Difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamidePI(22:3(10Z,13Z,16Z)/PGF1alpha)CE(PGJ2)MG(20:4(8Z,11Z,14Z,17Z)-2OH(5S,6R)/0:0/0:0)AntalarminGentamicin CProstaglandin D13-Dehydroquinic acidPI(18:2(9Z,12Z)/TXB2)T-4-AMINOCROTONIC ACID (TACA)13,14-Dihydro-15-keto-PGE21-(4-O-beta-D-glucopyranosyl-3-methoxyphenyl)-3,5-dihydroxydecaneLysoPC(22:0/0:0)Lithocholic acid glycine conjugateCL(8:0/11:0/15:0/i-24:0)Cimiaserin B4,4'-Dioctyldiphenylamine(2S)-2-[[2-[(2S,3S)-2-[[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentoxy]-1-oxo-3-phenylpropyl]amino]-4-methylsulfonylbutanoic acid propan-2-yl esterAndrosterone glucuronide5-Methyltetrahydropteroyltri-L-glutamic acidLycopersiconolideIndoleRHODANINEPI(6 keto-PGF1alpha/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Citrusinine II3,4-Dimethyl-5-pentyl-2-furanpropanoic acidUlimorelinPC(P-18:0/20:3(8Z,11Z,14Z)-2OH(5,6))Angoroside CProstaglandin A1Epsilon-CaprolactamHistidylargininePC(O-18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Ascorbyl stearatePGP(a-13:0/i-14:0)3-(4-(2-Dimethylamino-1-methylethoxy)phenyl)-1H-pyrazolo(3,4-b)pyridine-1-acetic acidPulchinenoside B4LeupeptinTetrahydropteroyltri-L-glutamic acidTeleocidin B 2PS(PGJ2/18:4(6Z,9Z,12Z,15Z))1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1h-pyrrole-3-carboxamideN-Isobutyloctadeca-trans-2-trans-4-dienamideCyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxideMonooctyl phthalateUric acidCyasteroneAlkaloid C from cephalotaxus2-Hydroxycinnamic acidDL-NorvalineIpamorelinPG(PGJ2/a-13:0)15-Hydroxy-5,8,11,13-eicosatetraenoic acid3a,17a-Dihydroxy-5b-androstaneAB-FubinacaPGF2alphaLysoPA(i-24:0/0:0)PeimineLysoPC(20:2(11Z,14Z)/0:0)L-PhenylalanineRUBRATOXIN BPI(PGJ2/20:3(5Z,8Z,11Z))ReproterolPregnan-20-oneSagopiloneTetradecanedioic acidDocosahexaenoic acidMomelotinibLauramine OxidePectenotoxin 1Pectenotoxin 2SphingosineHoduloside XPectenotoxin 7PE(P-18:0/0:0)PG(PGD1/a-25:0)GlycyrrhizinTetrahydrocortisoneGibberellin A9SM(d17:2(4E,8Z)/20:4(5Z,8Z,11Z,14Z)-OH(19S))9,12,13-TriHOMEDeltoninN-OleoyldopaminePI(TXB2/20:0)MycobactinsTrans-GrandmarinGDP-alpha-D-glucoseCDP-DG(i-15:0/i-12:0)BuprenorphineDG(20:0/14:1(9Z)/0:0)(13Z)-Octadec-13-enoylcarnitine(23R)-1alpha-Hydroxy-25,27-didehydrovitamin D3 26,23-lactoneSalutaridinolCabergolineZucchini factor BPE(18:3(6Z,9Z,12Z)/P-18:1(9Z))N-MonodemethylolopatadinePS(TXB2/14:1(9Z))Beta-Citryl-L-glutamic acidHexadecanedioic acid mono-L-carnitine ester(9E,12Z)-10-Nitrooctadeca-9,12-dienoylcarnitineChlorogenoquinoneHovenine ATrans-Dodec-2-enoic acidLysyl-aspartyl-glutamyl-leucineArg-Thr-Lys-ArgSerratolRifampicinL-Cysteine, N-acetyl-, ethyl ester5-p-Coumaroylquinic acidHydratopyrrhoxanthinol24-EpibrassinolideIbuprofen glucuronide1-(Carboxyethylthio)tetradecaneLeu Lys MetTryptophyl-ThreonineSclareol oxidePE-NMe(20:0/20:2(11Z,14Z))PGP(PGE1/i-24:0)CholylleucineXanthosineN-Linoleoyl HistidinePS(18:2(9Z,12Z)/20:0)Pisumoside BPA(19:2(10Z,13Z)/5-iso PGF2VI)MG(18:3(10,12,15)-OH(9)/0:0/0:0)Citric acidAlpha-D-Glucose 1,6-BisphosphateN-(2R-Hydroxyhexadecanoyl)-2S-amino-9-methyl-4E,8E-octadecadiene-1,3R-diol8(R)-Hydroperoxylinoleic acidDihydroneopinePC(22:5(7Z,10Z,13Z,16Z,19Z)/PGJ2)Gamma-GlutamylalanineGentiobioseL-HexanoylcarnitineTerpestacinUlipristalPregnanetriol 3a-O-b-D-glucuronideDesogestrelEicosatetraenoic acidPS(16:1(9Z)/15:0)DialdehydeTauroursodeoxycholic acidN-Myristoyl ProlinePE(P-18:1(11Z)/PGF1alpha)N-Palmitoyl TryptophanLithocholyltaurineTXB2PC(18:3(10,12,15)-OH(9)/P-18:0)2-Aminoethyl oleatePS(22:2(13Z,16Z)/18:0)Stearic acidSakuranetinD-TYROSINE15-Deoxyprostaglandin J2BUTHIDAZOLEPGP(PGD2/18:3(6Z,9Z,12Z))3-Hydroxy-1-phenyl-1-octadecanonePA(18:3(10,12,15)-OH(9)/2:0)Beta-TyrosinePG(20:5(5Z,8Z,11Z,14Z,16E)-OH(18)/i-22:0)Chitin13-cis RetinolOxyacanthineQuinquenoside VDermorphin1,25-Dihydroxy-16-ene-23-yne-vitamin D3Cucurbic acidLysoPE(18:0/0:0)PG(a-21:0/18:1(12Z)-2OH(9,10))Prostaglandin I25-Methoxyindoleacetate(6Ar,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,9,10,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid6S,9R-Dihydroxy-4,7E-megastigmadien-3-one 9-[apiosyl-(1->6)-glucoside]NuatigeninGlucocapparinDG(20:5(5Z,8Z,11Z,14Z,16E)-OH(18)/0:0/i-20:0)PC(20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)/2:0)Cholesteryl hemisuccinateNystatin A3THYMOPENTINPS(16:1(9Z)/14:1(9Z))CholylcitrullineButyryl-L-carnitine3-KetosphingosinePIP(22:2(13Z,16Z)/20:4(5E,8Z,12Z,14Z)-OH(11R))Prostaglandin J2Cys-Arg-Glu-Lys-AlaDocosanedioic acidN-Stearoyl Aspartic acidPI(22:2(13Z,16Z)/PGE1)N-Oleoyl Cysteine3,8-Dihydroxy-6-methoxy-7(11)-eremophilen-12,8-olideMilbemycin A4N-Stearoyl ValineBoceprevirTestosterone PropionateDeoxycholylarginineCyclohexanecarboxamideGlycylphenylalanylleucylglycinePA(18:3(9Z,12Z,15Z)/20:0)22-Hydroxydocosanoic acidChinenoside IIICDP-DG(i-12:0/i-18:0)Crassostrea SecocarotenoidTaurinePerindoprilatGamma-Glu-LeuDG(22:0/20:3(8Z,11Z,14Z)-2OH(5,6)/0:0)Janthitrem BLeukotriene F4Cinncassiol D3PI(6 keto-PGF1alpha/18:2(9Z,12Z))CelestoneDidemnin CPE(16:0/15:0)Methyl 5-(1-Propynyl)-2-thiophenepropanoateCob(I)yrinate a,c diamideL-ThreonineCyclopamineDG(a-21:0/0:0/20:4(5Z,8Z,11Z,14Z)-OH(18R))DG(a-13:0/22:6(5Z,8E,10Z,13Z,15E,19Z)-2OH(7S, 17S)/0:0)Smilanippin A8-Amino-7-oxononanoic acid9,10-Epoxyoctadecanoic acidProscillaridinSM(d18:0/16:1(9Z))Myristoleic acidL-LeucineEnhydrin(1R,4R,4'R,5S,5'S,6R,6'S,7R,9R,11R,12R,13S,14S)-12-[(3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-4-ethyl-5,5',6,11-tetrahydroxy-4'-methoxy-4',5,6',7,9,11,13-heptamethylspiro[3,15,17-trioxabicyclo[12.4.0]octadecane-16,2'-oxane]-2,8-dioneFalcarindiol(17alpha,23S)-17,23-Epoxy-29-hydroxy-27-norlanosta-1,8-diene-3,15,24-trionePrednisoneGanoderic acid HGanoderic acid FPS(15:0/22:2(13Z,16Z))PA(20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15)/10:0)Deterrol stearatePC(18:0/0:0)PE-NMe2(24:0/22:4(7Z,10Z,13Z,16Z))LysoPC(20:4(8Z,11Z,14Z,17Z)/0:0)Hordatine AGlycerol 1-(5-hydroxydodecanoate)Perilloside BDG(20:3(6,8,11)-OH(5)/0:0/16:0)Camellioside CS-(PGA1)-glutathione13-L-Hydroperoxylinoleic acidLoperamideTG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/20:3(5Z,8Z,11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))N(4)-Octadecyl-1-arabinofuranosylcytosine16-Hydroxy-10-oxohexadecanoic acidGlucosyl passiflorateL-PalmitoylcarnitineSaponin HPG(18:1(9Z)/0:0)TangeraxanthinBrecanavirLeukotriene C51-HeptadecanoylglycerophosphoethanolamineLeukotriene C4LysoPE(22:5(4Z,7Z,10Z,13Z,16Z)/0:0)Carbocyclic thromboxane A2Angiotensin I, des-leu(10)-L-TryptophanN-Linoleoyl Glutamine11-Meo-fesCropropamideCholesterol glucuronide6-Keto-PGF1alpha3-Fucosyllactose(1R,9S)-10-(Cyclopropylmethyl)-12-ethyl-4-hydroxy-13-methyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-8-oneMethionine aspartate aspartateD-(+)-Cellobiose3-oxocholest-4-en-26-oateJesaconitine25-Cinnamoyl-vulgaroside(6b,7b,13R)-6,7-Diacetoxy-8,14-labdadiene-13-olTyr-ile-gly-ser-argN-Acetyl-beta-alanine1-heneicosanoyl-glycero-3-phosphateARGININOSUCCINATE1-(3-fluorobenzoyl)-N-(5-propyl-1,3,4-thiadiazol-2-yl)piperidine-4-carboxamideValylmethioninePC(P-16:0/18:1(12Z)-2OH(9,10))(5Z)-7-[(1R,2R,5S)-5-Hydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dien-1-yl]-3-oxocyclopentyl]hept-5-enoylcarnitineOleanolic aldehydePGP(22:5(4Z,7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))CollagenN-(8-Amino-1-carboxyoctyl)-alanyl-prolineUracilEicosapentaenoic acidTilmicosin(R)-2-Amino-3-(2-propynylthio)propanoic Acid2-Chlorohexadecanoic AcidGinsenoside Ra2Nopalinic acidDG(18:1(9Z)-O(12,13)/0:0/16:0)Mepartricin(8alpha,10alpha,13alpha,17beta)-17-[(4-Hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acidHordatine B glucoside(13Z,16Z,19Z)-Docosa-13,16,19-trienoylcarnitineBehenic acidCholesterol sulfatePalmitoyl glucuronide1h,8h-Pyrano[3,4-c]pyran-1,8-dioneBenzaroneSM(d20:1/PGE1)Azukisaponin III18-Dehydroursolic acid 3-arabinosidePS(18:1(9Z)/18:0)4-AminoantipyrineSar-Arg-Val-Tyr-Val-His-Pro-AlaLys-Lys-OHStallimycinDG(TXB2/8:0/0:0)2-(4-Nitrobenzylidene)malononitrileDibutyryl adenosineHyaluronan biosynthesis, precursor 1Pyridin-3-ylmethyl N-[(2S,4S,5S)-4-hydroxy-5-[[(2S)-3-methyl-2-[[methyl(1,3-thiazol-4-ylmethyl)carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamateBudralazine7alpha,12alpha-Dihydroxycholest-4-en-3-oneCarboxymethyl chitosanRotundifolineN-lactoyl-TyrosineSM(d18:1/PGJ2)Atn-161TG(8:0/8:0/13:0)(1alpha,3beta,20S,22R,24S,25S)-Pubescenin(2S)-2-Amino-3-[(2S,3R)-2-amino-3-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxybutanoyl]oxypropanoic acidPIP(6 keto-PGF1alpha/20:2(11Z,14Z))Alpha-BixinHomocarnosineS-(9-deoxy-delta9,12-PGD2)-glutathioneSM(d18:1/LTE4)1,3-Diacetoxy-4,6,12-tetradecatriene-8,10-diyneISOPROPYLAMINEN-Methyl-2-phenyl-n-[(5r,7s,8s)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamideCilastatinVirginiamycin m14-(Aminomethyl)-1-methylpiperidin-4-olDG(20:4(8Z,11Z,14Z,17Z)/22:5(7Z,10Z,13Z,16Z,19Z)/0:0)Glyoxal5-KETE3-Octadec-9-enoyloxy-4-(trimethylazaniumyl)butanoatePA(14:1(9Z)/LTE4)PE(18:0/0:0)DalamidTulathromycin AAminocaproic AcidPE-NMe(18:3(9Z,12Z,15Z)/22:1(13Z))Gentamicin C2LysoPC(22:2(13Z,16Z)/0:0)Paramethasone acetateDeethylatrazineZedoarolVal-Pro-Asp-Pro-ArgBardoxoloneDG(PGJ2/0:0/i-16:0)Neogitogenin 3-[glucosyl-(1->2)-glucosyl-(1->4)-galactoside](R)-2',4',7-Trihydroxy-3',8-diprenylisoflavan16-Hydroxyhexadecanoic acidCDP-DG(20:5(5Z,8Z,11Z,14Z,16E)-OH(18R)/i-15:0)Prehumulinic acidGimatecanStearamideTyramineLeu-Arg-Asn-Arg11H-14,15-EETA12-Hydroxydodecanoic acid16-Mercaptohexadecanoic acid[3-[2,3-Dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-hydroxypropyl] hexadecanoateN-Demethyl MifepristonePergolideDN-isobutylamideN4-AcetylcytidinePE(20:3(6,8,11)-OH(5)/18:0)N-Myristoyl ArginineGlycerophosphocholineErgothioneinePhytosphingosine-1-PLysoPE(0:0/22:0)6-Amino-N-[6-keto-6-(6-ketohexylamino)hexyl]hexanamide3-PalmitoylcatechinBufotenine O-glucosideN-Eicosapentaenoyl ArgininePE(24:1(15Z)/15:0)Leucomycin a5LysoPA(24:0/0:0)8beta-Angeloyloxy-15-hydroxy-1alpha,10R-dimethoxy-3-oxo-11(13)-germacren-12,6alpha-olideS-(11-hydroxy-9-deoxy-delta12-PGD2)-glutathioneCinobufotalin(3S,7E,9R)-4,7-Megastigmadiene-3,9-diol 9-[apiosyl-(1->6)-glucoside]PG(i-22:0/PGE1)TetrahydrodeoxycortisolN-Lactoylphenylalanine1-(1-(Tert-Butoxycarbonyl)piperidin-4-yl)azetidine-3-carboxylic acidCoelenterazine9'-Carboxy-gamma-chromanolLysoPC(24:1(15Z)/0:0)1-hexadecylpyridiniumPI(TXB2/16:2(9Z,12Z))CDP-DG(a-13:0/i-12:0)L-GlutamineL-Asparagine, L-alanyl-L-tyrosyl-L-methionyl-L-threonyl-L-methionyl-L-lysyl-L-isoleucyl-L-arginyl-2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinolCyclopenthiazide1-Stearoylglycerophosphoserine3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-octanoateDG(16:0/20:3(8Z,11Z,14Z)-2OH(5,6)/0:0)Cerivastatin lactonePeridininCibaric acidBlasticidin SN-ButylbenzenesulfonamideGlyphosateCerebellinLysoPE(P-18:1(9Z)/0:0)L-IsoleucineGymnodimineRepaglinide aromatic amineN-Stearoyl HistidineAplavirocDihydrodeoxy-8-epiaustdiolTirofibanN-lactoyl-MethionineCer(d18:1/PGE2)O-methylmalonyl-L-carnitine9,10,11-Trihydroxyumbelliprenin2-Deoxygalactopyranose(S)-2-Acetamido-3-(4-chlorophenyl)propanoic acidN-Docosahexaenoyl ThreonineDrostanoloneLysoPA(a-13:0/0:0)Pengitoxin1-eicosanoyl-glycero-3-phosphateBrevetoxin B211,14,15-THETAMG(18:3(6Z,9Z,12Z)/0:0/0:0)Palmitoylcarnitine3-MethylindoleAnnocherin AAlpha-Butyl-omega-hydroxypoly(oxyethylene) poly(oxypropylene)PS(18:1(9Z)/22:1(13Z))LysoPC(15:0/0:0)Laurolitsine2-MercaptobenzothiazoleDepreotideSolasodineIsoleucyl-MethionineStreptomycin sulfateL-Aspartic acidThreonylmethionineLysoPC(22:5(4Z,7Z,10Z,13Z,16Z)/0:0)PE(P-18:0/PGE1)5'-CMP7alpha-Hydroxy-3-oxo-4-cholestenoate(3S,3'S,5R,5'R,6R)-3,6-Epoxy-5,6-dihydro-3',5,8'-trihydroxy-beta,kappa-caroten-6'-oneBetavulgaroside XThromboxane B2AscladiolChiisanoside6-methyl-5-Hepten-2-oneD-Erythrose-4-PhosphateCis-3-Decene(4Z,7Z,10E,12E,16Z)-18-(3-Ethylcycloprop-1-en-1-yl)-14-hydroxyoctadeca-4,7,10,12,16-pentaenoylcarnitineSerylphenylalanineHebevinoside XIV11-HpODEDethiobiotinPS(18:1(9Z)/16:0)RosmaricineMomordenolIrinotecan3-Hydroxy-N6,N6,N6-trimethyl-L-lysine5,6-Dihydroxyprostaglandin F1a28-[Glucosyl-(1->6)-glucosyl]oleanolic acid 3-[glucosyl-(1->3)-[arabinosyl-(1->4)]-glucuronide]Hippuryl-histidyl-leucineMG(0:0/18:3(9Z,12Z,15Z)/0:0)EstroneTetracosanedioic acidOpiorphin15-deoxy-delta-12,14-PGJ228-Homobrassinolide5-Oxoicosa-3,6,8-trienoic acidDeacetylvinblastine2-Hydroxydodecyl methacrylateSorbitol lactateL-OctanoylcarnitineDG(22:2(13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)BufadienolideIsopropyl beta-D-glucosideGinsenoside C-KButyryl trihexyl citrateN(4)-Oleylcytosine arabinosideAspartame6-Hydroxy-8-heneicosanoneMicrocystin RRPE(20:3(8Z,11Z,14Z)/P-18:0)2,6-Dimethylaniline11-Oxohexadecanoic acidChandaloneIndoxyl SulfateChlorobenzene15(S)-Hydroxyeicosatrienoic acidSENECIPHYLLINETyrosylhydroxyproline6-Hydroxyhexanoic acidPE(P-16:0/20:3(8Z,11Z,14Z)-2OH(5,6))Prostaglandin E2 methyl esterPI(TXB2/18:2(9Z,12Z))PS(18:3(9Z,12Z,15Z)/24:0)ElarofibanPIP(TXB2/22:2(13Z,16Z))CDP-DG(TXB2/i-17:0)Guanosine 3'-monophosphatePE(22:5(4Z,7Z,10Z,13Z,16Z)/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))Polyoxyethylene 40 monostearateDaphniphyllinePG(a-21:0/TXB2)Cysteineglutathione disulfideProstaglandin-c2(1R,3S)-3-(6-Aminopurin-9-yl)cyclopentan-1-olPGF2a ethanolamideMethylphenidatePA(22:2(13Z,16Z)/18:1(12Z)-2OH(9,10))PS(24:0/PGE1)PE(20:0/PGJ2)Soyasaponin bgLysoPE(P-16:0/0:0)D-Phenylalanyl-L-2-piperidinecarbonyl-N-(4-nitro phenyl)-L-argininamideThionitrous acidGuanosine monophosphate2-Hydroxy-4-octenoylcarnitine9,10,13-TriHOMELysoPC(P-16:0/0:0)(E)-3-oxo-beta-iononeDeoxypyridinolinePI(18:0/18:2(9Z,12Z))Leustroducsin BEucarvone5-hydroxyindole thiazolidine carboxylateN-[(3a,5b,7a)-3-hydroxy-24-oxo-7-(sulfooxy)cholan-24-yl]-GlycineMiglitolPE(TXB2/24:0)Asticolorin BPIP(16:0/PGF2alpha)P-Coumaric AcidPGP(a-13:0/i-13:0)LysoPE(16:1(9Z)/0:0)GinsengPE(16:0/0:0)Dimethyl 3-methoxy-4-oxo-5-(8,11,14-pentadecatrienyl)-2-hexenedioate(R)-LaudanidineAminocarbN-Acetyl-L-methionine4-Amino-1-[(2R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one4-Hydroxy-6-nonadecanonePA(a-15:0/PGF2alpha)AlprostadilADPCytochalasin BUrobilinogenCDP-DG(18:3(9Z,12Z,15Z)/18:2(9Z,12Z))Ile Thr IleCarboxyfentanyl(2,6-Dioxo-3H-purin-9-yl) pyridine-3-carboxylateJosamycinTetradecanoylcarnitineHexadecanedioic acidArenobufaginPS(14:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))BiliverdinPyripyropene ASpisulosineEdoxudineArabinofuranosylguanine(1R,7S,13S,15S)-2,15-Dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-oneAmphibine HPS(20:0/18:1(11Z))Annomuricatin BPS(18:1(9Z)/18:1(11Z))PS(16:1(9Z)/24:0)FenvalerateSulfamethazineOxalacetic acidSerylmethioninePS(14:1(9Z)/20:5(7Z,9Z,11E,13E,17Z)-3OH(5,6,15))UridinePC(PGJ2/DiMe(11,5))PC(2:0/18:1(12Z)-2OH(9,10))Polyporusterone GEthyl4-ethoxy-6-methylnicotinate8-HydroxymianserinCervonoyl ethanolamideCurdioneDIMP3'-Adenylic AcidAngiotensin IVPuromycinPE(15:0/20:0)PE(P-18:1(11Z)/14:1(9Z))DG(10:0/i-15:0/0:0)Soyasapogenol B 3-O-[a-L-rhamnosyl-(1->2)-[b-D-glucosyl-(1->3)]-b-D-galactosyl-(1->2)-b-D-glucuronide] 22-O-[b-D-glucosyl-(1->2)-a-L-arabinoside]N-[1-[[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methyl-2-(propanoylamino)pentanamide(3S,5R,6S,7E,9x)-7-Megastigmene-3,6,9-triol 9-glucosideVitamin E NicotinateXanthomonic Acid6-Keto-prostaglandin F1aMetampicillinJacarandic acid(3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-alDihomolinoleic acid4-Propanoyl-HT2 toxinPC(17:0/0:0)CDP-DG(6 keto-PGF1alpha/i-22:0)(Z)-5-[(2R,3S,4S)-4-Hydroxy-2-[(E)-3-hydroxyoct-1-enyl]oxan-3-yl]pent-3-enoic acidArg-gly-asp-serN'-nitrosoanabasineGanosporeric acid AL-TyrosineMelevodopaIneketoneMyotoxin A4-Butyl-5-hydroxy-1,2-diphenylpyrazol-3-oneOcotillolPI(20:0/TXB2)PC(18:1(9Z)e/2:0)Notoginsenoside C(2R)-2-[[(1R,3S,4S)-3-[[4-(5-Benzyl-2-ethylpyrazol-3-yl)piperidin-1-yl]methyl]-4-(3-fluorophenyl)cyclopentyl]-methylamino]-3-methylbutanoic acid(Z)-3-(1-Formyl-1-propenyl)pentanedioic acid(R)-1-O-[b-D-Apiofuranosyl-(1->2)-b-D-glucopyranoside]-1,3-octanediolPE(PGJ2/14:1(9Z))Kudzusaponin SA3Kudzusaponin SA2Tricosanoylglycine[(2R,3S,4S,6R,7S,8R)-4-Ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[2-(diethylamino)ethylsulfanyl]acetate3,4-Dimethyl-5-propyl-2-furandecanoic acidDibekacin7-hydroxygranisetron2,5-DioxopentanoateCarminomycin IIS-(9-hydroxy-PGA1)-glutathionePhenylbutyrylglutamine2-Naphthylaminomethyl-gamma-aminobutyric acidM-Xylene1b,3a,7b-Trihydroxy-5b-cholanoic acid10-Hydroxy-2-decenoic acidPC(O-18:0/20:4(8Z,11Z,14Z,17Z))1-docosanoyl-glycero-3-phosphatePropionylcarnitineO6-Carboxymethyl-2'-deoxy-guanosine4-Hydroxyretinoic acidOmega-hydroxyfinasterideCholylasparagine(Z)-7-[(1R,2R,3R,5S)-2-(1,2-Dihydroxy-3-oxooctyl)-3,5-dihydroxycyclopentyl]hept-5-enoic acidDG(20:4(5E,8Z,12Z,14Z)-OH(11R)/0:0/16:0)4-ene-Valproic acidGeosminDeoxycholylasparagineApo-12'-zeaxanthinalGinsenoside RoPerindoprilDG(8:0/0:0/PGJ2)Docosapentaenoic acid (22n-3)Lactupicrin methyl esterArginylhydroxyprolineBradykinin hydroxyprolineN-[2-(3,4-Dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide3-Methylcholanthrene5'-Deoxy-5'-fluorouridineLysoPC(16:1(9Z)/0:0)ConvallosideCholylthreonineMammeisin5'-MethylthioadenosineCer(d18:1/16:0)Desglucodesrhamnoparillin5b-Cholestane-3a,7a,12a,23-TetrolDathf2-Methylhexadecanoic acidLoganateAstromicinDesacetycefapirin2,3-Dihydroxycarbamazepine4-VinylcyclohexeneDimethylsphingosinePE(PGD1/P-18:0)4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol1-O-Hexadecyl-sn-glycero-3-phosphocholinePS(18:3(9Z,12Z,15Z)/LTE4)Notoginsenoside ILysoPE(20:3(5Z,8Z,11Z)/0:0)QuadrangulosideLisinopril, epsilon-biotinamidocaproyl-4'-Hydroxy-R-phenprocoumonPetroselinic AcidSorbitan oleateGallamonumN-Myristoyl TryptophanPE(PGJ2/20:2(11Z,14Z))N-Stearoyl ArginineVinaginsenoside R12Dehydrodidemnin BHeliotridine2-Amino-2-deoxy-D-gluconic acidDG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/20:1(11Z)/0:0)Galabiosylceramide (d18:1/9Z-18:1)Palmitic amideMG(24:1(15Z)/0:0/0:0)Linoleoyl ethanolamideLysoPE(20:2(11Z,14Z)/0:0)DeoxycholyltyrosineCycloserineCyanidin 5-O-beta-D-glucosideSM(d18:0/24:1(15Z)(OH))CinobufaginMyrianthic acidMomordicoside C(13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acidAminopterinPA(20:2(11Z,14Z)/20:5(6E,8Z,11Z,14Z,17Z)-OH(5))S-(9-hydroxy-PGA2)-glutathione(2S,3R)-2-Acetamido-3-hydroxy-4-methylpentanoate2-[[3-Cyclohexyl-1-[2-[3-(diaminomethylideneamino)propylcarbamoyl]piperidin-1-yl]-1-oxopropan-2-yl]amino]acetic acidMG(18:1(11Z)/0:0/0:0)DG(20:4(8Z,11Z,14Z,17Z)/18:1(9Z)/0:0)RemikirenAacocf3PE(18:0/22:1(13Z))Floionolic acidPE(20:0/15:0)Cytidine17-Aminogeldanamycin7-(3,5-Dimethyl-1,2-Oxazol-4-Yl)-6-Methoxy-2-Methyl-4-(Quinolin-4-Yl)-9h-Pyrimido[4,5-B]indoleLysoPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)Melleolide BEMycin EIsoquinolinePI(PGD2/20:4(8Z,11Z,14Z,17Z))O-DemethylencainideGalactosylhydroxylysineEthylmorphine7,8-Dihydrovomifoliol 9-[apiosyl-(1->6)-glucoside]7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3S)-3-hydroxyoctyl]cyclopentyl]heptanoylcarnitineMontirelinPS(18:1(11Z)/18:3(9Z,12Z,15Z))N-Docosahexaenoyl ArginineN-Linoleoyl Tyrosine7-(5-Hexyl-3,4-dimethylfuran-2-yl)heptanoylcarnitinePhytolaccasaponin BAmylamineIndolaprilHexahydrocurcuminDeoxyspergualinEndomorphin-1Sphinganine14-DeoxyandrographolideGlycocholic AcidGlutathione, oxidizedGuanadrelCandicidinGlycerol glutamate2-Amino-4-[carbamimidoyl(methyl)amino]butanoic acidPI(6 keto-PGF1alpha/22:4(7Z,10Z,13Z,16Z))[[(3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]amino] N-phenylcarbamateAPC4-Allylpyrocatechol sulfateOxidized GlutathioneDG(18:1(11Z)/18:2(9Z,12Z)/0:0)1-Oleoyl-sn-glycero-3-phospho-D-myo-inositol(1-)CimaterolPI(18:2(9Z,12Z)/LTE4)LysoPE(0:0/18:0)PS(20:0/18:2(9Z,12Z))RentiaprilCalenduloside G methyl esterIsovaleryl-Val-Val-Sta-OEtAdhumuloneDG(i-14:0/20:4(6E,8Z,11Z,14Z)+=O(5)/0:0)LysoPA(16:0/0:0)13'-Hydroxy-gamma-tocotrienol(8Z,11Z)-Henicosa-8,11-dienoylcarnitine2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamineNetilmicinCer(d18:1/20:3(8Z,11Z,14Z)-2OH(5,6))SinapineIsoleucyl-ArginineN-lactoyl-phenylalaninePC(PGJ2/22:0)3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate20-Hydroxy-leukotriene E41-ButeneLysoPC(22:4(7Z,10Z,13Z,16Z)/0:0)PS(18:1(12Z)-2OH(9,10)/22:0)StyreneDeoxyloganic acidPS(18:3(9Z,12Z,15Z)/18:0)Tuliposide APelargonidin 3-sophorosideL-Histidinol1-Nonadecanoyl-glycero-3-phosphoserineRelamorelinPGP(TXB2/i-14:0)Coproporphyrinogen IIICyclo(Pro-Phe-D-Trp-Lys-Thr-Phe)Cinncassiol CLauryldiethanolamineNarciclasineDeferoxamineAlpha-Eudesmol5-Amino-1-[(2R,3R,4S,5R)-5-[(benzylamino)methyl]-3,4-dihydroxyoxolan-2-yl]imidazole-4-carboxamidePGP(LTE4/a-25:0)DaunorubicinLinoleamideVigabatrinDG(20:5(5Z,8Z,11Z,14Z,17Z)/16:0/0:0)PA(24:1(15Z)/22:2(13Z,16Z))Neuromedin NPC(P-16:0/PGF1alpha)N,N-DiethyldodecanamideEndo-1,4-beta-XylanaseCornoside3,4-DihydroxydodecanoylcarnitineDG(18:1(11Z)/18:3(9Z,12Z,15Z)/0:0)2-(3-Mercaptopropyl)pentanedioic acidN-Lauroyl GlutamineZeranolOctadec-9-enoic AcidRacemethioninePI(22:4(10Z,13Z,16Z,19Z)/6 keto-PGF1alpha)2,7-Difluoro-4-methoxyspiro[fluorene-9,5'-imidazolidine]-2',4'-dioneFosteabineFarnesylcysteineSer Gly Gln20-Hydroxy-6Z,15Z-eicosadienoic acidL-prolinamideIndolelactic acidLysoPC(18:3(6Z,9Z,12Z)/0:0)6-Hydroxy-4-heneicosanonePC(DiMe(13,5)/DiMe(13,5))DulcisisoflavoneCer(d16:1/18:1(9Z)-O(12,13))DG(14:0/20:4(5Z,8Z,11Z,14Z)-OH(16R)/0:0)2H-1-Benzopyran-2-one, aminomethyl-Hypoglycin BPAF C-18Bisnorcholic acid(S)-Menthone 8-thioacetateFucoxanthinolAlpha-Linolenic acidRiginPGF3alpha2-Oxo-3-hydroxy-lysergideL-a-Lysophosphatidylserine3-HydroxyarachidonoylcarnitineLovastatin acidCDP-DG(a-13:0/a-13:0)DG(18:0/16:0/0:0)5,6-epoxy,18R-HEPECoumarin(2R)-2-Acetamido-6-hydroxy-2-(sulfanylmethyl)hex-3-enoic acidCDP-DG(PGJ2/20:1(11Z))Withangulatin ASpermineCortolone-3-glucuronideSTREPTOZOTOCINHept-2-en-1-yl isovalerate5(6)-Epoxy Prostaglandin E15-Hydroxycapsanthin-5,6-epoxide19-Oic-deoxycorticosteroneRIOPROSTILStrophanthidinL-Lyxonic acidHippuric acidPA(i-15:0/20:4(6E,8Z,11Z,14Z)-OH(5S))Notoginsenoside R1ButylateLysoPG(18:2(9Z,12Z)/0:0)3-deoxy-D-arabino-heptulosonate-7-phosphate4-(7-(((1R)-1-((3-Chloro-2-thienyl)methyl)propyl)amino)-3H-imidazo(4,5-b)pyridin-3-yl)-N-ethyl-2,3-dihydroxycyclopentanecarboxamide, (1S,2R,3S,4R)-PE-NMe(22:0/18:3(9Z,12Z,15Z))GalactosylsphingosineAlgesterone acetophenideBeta-hydroxyprednisoloneCholylserineVellosimineDammeZankirenPalmitoleic Acid(-)-FolicanthineSenecionine N-oxideN-Lauroyl TryptophanOctaethyleneglycol monododecyl etherAzitromycinDactinomycin11-HydroxyNonadecanoylcarnitineLysoPC(22:1(13Z)/0:0)PA(24:1(15Z)/PGJ2)Pachymic acid4-Methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-glucopyranosidePI(PGJ2/20:4(8Z,11Z,14Z,17Z))L-SerineTsangane L 3-glucosidePhysapruin BDihydroergocryptineSchidigerasaponin B1OuabainCortoloneGentiopicrosideLucidenic acid M11beta,20-Dihydroxy-3-oxopregn-4-en-21-oic acidN-CholoylglycineGamma-Chaconine5-Aminovaleric AcidPC(P-18:0/0:0)AnserineDelta9-Tetrahydrocannabinol hemisuccinateHovenidulcigenin BZ-Gly-Gly-Arg-AMCCryptophycin5-Benzyl-2-[[4-(3-chlorophenyl)piperazin-1-yl]methyl]-6-methylpyridazin-3-oneN-Docosahexaenoyl AlanineMisoprostol acidCucurbitacin IAconineCucurbitacin DSarpogrelateSebacic acidPA(18:3(10,12,15)-OH(9)/14:1(9Z))Caribbean ciguatoxin 1Prostaglandin F2alpha methyl esterTigecyclineReichsteins substance SMethyl-[12]-gingerdiolArticainic acidAtractylenolide IIISAICARPG(16:1(9Z)/16:0)L-4-Hydroxyglutamate semialdehydePhaseollinisoflavanPlazomicinOrotidylic acidFludrocortisone1-Adamantanecarbonyl-RF-NH2Acetylenedicarboxylic acidPE(18:4(6Z,9Z,12Z,15Z)/P-18:0)LysoPI(18:0/0:0)D-DopachromePS(22:2(13Z,16Z)/20:5(5Z,8Z,11Z,14Z,17Z))PimetinePenitrem DPenitrem EMocimycinDiisobutyl phthalateAspartylglycosaminePG(20:4(5Z,8Z,11Z,14Z)/18:0)Cis-SabinolPI(20:3(8Z,11Z,14Z)/TXB2)Cortisol lactateBioMed 101PE(22:6(4Z,7Z,10Z,12E,16Z,19Z)-OH(14)/20:5(5Z,8Z,11Z,14Z,17Z))EcdysonePinolidoxin(R-(R*,S*))-3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidine-4-heptanoic acid2-OxoarginineFludrocortisone acetateGinsenoside F2PC(PGJ2/20:0)Methoxy arachidonyl fluorophosphonateLappaol DButanalLappaol AAnnosquamosin BS-AdenosylmethionineFraxinD-Sedoheptulose 7-phosphate4-(8-Methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)benzenamine2-Hydroxy-6-pentadecylbenzoic acidL-Threo-3-PhenylserineMonotropeinPA(a-15:0/TXB2)Manoalide2-Chlorooctadecanoic acid2-(4-(3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy)phenoxy)acetic acidDibutyl phthalateThymidineDesacetyllevonantradolTranexamic AcidCalcifediol lactoneSM(d18:1/PGE2)VinfosiltineVitamin D3 sulfate4-Hydroxypropranolol glucuronide(S)-6-Acetamido-2-(2-((S)-2-acetamido-4-methylpentanamido)acetamido)-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamideLysoPE(18:2(9Z,12Z)/0:0)PS(16:1(9Z)/PGE2)MG(0:0/18:0/0:0)Phytocassane BGMP-N-epsilon-(N-alpha-acetyl lysine methyl ester) 5'-phosphoramidateN,N-DimethylarginineLysoPE(16:0/0:0)1-Arachidonoylglycerol3h-AdrenalineDG(O-16:0/18:0/0:0)GlycylprolylarginineOxolinic acidFoeniculoside XCanrenoic acidPralmorelinDmap-ethyl-pafMammea B/BC cyclo E11(R)-HETEPS(20:2(11Z,14Z)/20:0)9,10,13-Trihydroxystearic acidChenodeoxycholylarginineCyclosquamosin ATyr GlyN-Methyl-D-aspartic acidPE(20:4(5Z,8Z,11Z,14Z)-OH(20)/P-16:0)Prostaglandin F3aPE(22:6(4Z,7Z,11E,13Z,15E,19Z)-2OH(10S,17)/24:1(15Z))P-Hydroxyhippuryl-his-leu-OHLysoPE(22:1(13Z)/0:0)(4E,15Z)-BilirubinChenodeoxycholyltyrosinePro IleCer(d16:1/PGJ2)SM(d18:0/PGE2)PS(22:4(7Z,10Z,13Z,16Z)/20:0)PG(a-13:0/i-12:0)(11R,16S)-misoprostol12-hydroxyheptadecanoic acidLyciumoside IIIAntamanideCholyltyrosineMilbemycin beta3MedroxyprogesteroneSpirolide F6-methylthiohexyldesulfoglucosinolateProstaglandin F2bGirinimbinePS(20:0/PGF1alpha)Pubesenolide(10R,13S,17S)-17-Hydroxy-13-methyl-10-[(4-methylphenyl)methyl]-17-prop-1-ynyl-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-oneSpirolide DPS(22:0/20:5(6E,8Z,11Z,14Z,17Z)-OH(5))Chromogenic Substrate S-2266DesacetylcephalothinDesoxylimoninArctiopicrinS-LactoylglutathioneD-Mannose 6-PhosphateChrysin(1S,2S,4R,8R)-p-Menthane-1,2,9-triol12-Keto-tetrahydro-leukotriene B4LubiprostoneRusselioside BPC(PGD1/20:1(11Z))Prostaglandin F1aTauro-24,25-dihydrofusidatefalseLC- MS based untargeted metabolomic analysis of exsome-derived lung graft<p>A total of 50 mg of the same anatomical region of the lung graft(Syn group, N = 3; CR group, N = 9) was added to a 2 mL centrifuge tube to perform the untargeted metabolic analysis, Each QC sample is of the same volume as the test samples and is processed and detected using the same methods as the analytical samples. During instrumental analysis, a QC sample is inserted after every 5 to 15 analytical samples to monitor the stability of the overall analytical process. </p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