MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14815/m_MTBLS14815_LC-MS_alternating_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14815/a_MTBLS14815_LC-MS_alternating_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14815/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14815/s_MTBLS14815.txtprimary200OKftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14815<p>Peak detection, filtering, and alignment were performed via the XCMS in R (v3.1.3), generating a data matrix containing mass-to-charge ratio (m/z), retention time, and peak intensity for all precursor ions.</p>MetaboLightsPublicLiquid Chromatography MS - alternating - hilic<p>Thermo Scientific Vanquish UHPLC System, ACQUITY UPLC BEH Amide (1. 7 km, 2. 1 mm x 100 mm; Waters), HILIC</p>Circadian Disruption Compromises Neurodevelopment via Metabolic Reprogramming, Redox Imbalance and Genome Instability.Lanzhou UniversityBixi Zhaowholemass spectrometry assay<p>Metabolites were extracted using pre-chilled methanol/acetonitrile/water (2:2:1, v/v/v)</p>Danio reriohttps://www.ebi.ac.uk/metabolights/MTBLS14815Haiyu Zhao. Lanzhou University. zhaohy@lzu.edu.cn.Bixi Zhao. Lanzhou University. zhaobx2023@lzu.edu.cn.<p>Raw data were converted to mzXML format using ProteoWizard (v3.0.8789).</p>Circadian rhythmzhaobx2023@lzu.edu.cn<p>Zebrafish larvae at 7dpf (30 larvae per sample) from control and jet lag groups were collected, snap-frozen in liquid nitrogen, and transported on dry ice.</p>MetabolomicsThermo Scientific Vanquish UHPLC SystemJet-LagMetabolomicsControlThermo Scientific Q Exactiveuntargeted analysiscircadian rhythmDanio rerioZebrafishwholepooled sampleuntargeted metabolite profilingThermo Scientific Vanquish UHPLC SystemJet-LagMetabolomicsControlThermo Scientific Q Exactiveuntargeted analysiscircadian rhythmDanio rerioZebrafishwholepooled sampleuntargeted metabolite profiling<p>Thermo Scientific Q Exactive, electrospray ionization, alternatins, 70-1200</p>CisaprideCorticosteroneTrans-3'-hydroxycotinine o-.beta.-d-glucuronideMilnacipranMorphine n-oxide1,3-dimethyluric acid3-pyridinecarboxaldehyde1h-indole-1-pentanoic acid, 3-(1-naphthalenylcarbonyl)-Loxistatin acidThr-Val-LeuPantothenolKinetinMethapyrileneArg-Arg-LysReserpineFlufenacetAnabaenopeptin bAnabaenopeptin aIminodiacetic acidSaikosaponin aAcetylpodocarpic acid anhydrideLisinopril (8r,s)-diketopiperazineDL-proline6.beta.-hydroxynorethindroneMethyl 5,6-diacetyloxy-10-hydroxy-2,4b,7,7,10a,12a-hexamethyl-12-methylidene-1,4,8-trioxo-4a,5,6,6a,9,10,10b,11-octahydronaphtho[1,2-h]isochromene-2-carboxylateCarprofenGlycolatePropanoic acid, 2-[[4-[2-[[[(2,4-difluorophenyl)amino]carbonyl]heptylamino]ethyl]phenyl]thio]-2-methyl-4'-o-(glca(1-2)glca) apigeninGly-Glu3-(1h-indol-3-ylmethyl)-6,18-dimethyl-12-(1-phenylethyl)-9,15-di(propan-2-yl)-1,4,7,10,13,16,19-heptazacyclotricosane-2,5,8,11,14,17,20-heptonePro-glnCyclohexylamineL-carnosineTetrahydrofolateD-erythro-sphinganine-1-phosphate.beta.-d-glucopyranosiduronic acid, 5-[3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1h-indol-1-yl]pentyl21-hydroxyprogesterone7-hydroxycoumarinAltenusinThr-Met-LysCimicifugoside h 2Beta-alanineCinchonineL-theanine.beta.-naphthol(5.alpha.)-androstane-3,11,17-trioneN-Acetyl-L-HistidineN-lauroyl-d-erythro-sphinganine5-isoprostaglandin-f2.alpha.-viHexylglutathioneVal-Tyr-ArgPantothenic acidEthiofencarbRitonavirCevadineN-phenyl-2-naphthylamineFlorasulamSaquinavir1-pyrrolidineheptanoic acid, 2-[(1e,3s,4s)-3-hydroxy-4-methyl-1-nonen-6-yn-1-yl]-5-oxo-, (2r)-Acetylglycine(desmethyl)hydroxycerivastatinPi 40:7Octaethylene glycol1,2-dioleoyl-sn-glycero-3-phosphatidylcholinePro-Glu-ArgCrustecdysonePi 40:6ChymostatinRutinose1h-indazole-4-carboxamide, n-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-Arg-Ser-ArgLinoleoylglycinePyridineAla-AlaTrans-traumatic acidDigitoxinTrans-3,5-dimethoxy-4-hydroxycinnamaldehydePc 42:11Phe-glyPhe-glu13,14-dihydro-16,16-difluoroprostaglandin f2.alpha.Androsterone glucuronideAsn-ValIndoleIle-Leu-LysDextromethorphanD-ornithineBenzenepropanamide, n-(6-chloro-2-benzothiazolyl)-3,4-dimethoxy-4h-1-benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-Isocitric acidFumonisin b1Ascorbyl stearatehydrocortisone 21-acetateResibufogeninN6-(1-iminoethyl)-l-lysineLeupeptinPhe-Gln-Arg21-deacetoxy-11-oxodeflazacort-3,20-hydrazinecarboxamide5-methyltetrahydrofolic acidEpoxiconazole3-methoxyprostaglandin f1.alpha.AdenosineDihydroresveratrol17-trifluoromethylphenyltrinorprostaglandin f2.alpha. methyl esterPhenamilCyasteroneGuanidoacetic acid3beta-hydroxydeoxodihydrodeoxygeduninFa 18:2+4o4-hydroxyisophthalic acidPc 38:6Tacrolimus3-(cyclohexylamino)-2-hydroxy-1-propanesulfonic acidLobelanidineDibucaineDauricineHydrindantin4-hydroxyphenylmaravirocMelatoninN-[(4-methylphenyl)sulfonyl]benzencarbothioamideCandesartanVulpinic acidPro-Tyr-LysIsoproterenolThr-SerOleyloxyethylphosphorylcholine4-piperidinecarboxamideS-lactoylglutathioneSphingosineCalcimycin1-butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9h-purin-2-yl]amino]-, (2r)-Pevonedistat5'-phosphoribosyl-5-amino-4-imidazolecarboxamide (aicar)2-Deoxyribose 5-phosphateVal-Ser-ArgN-acetyl-d-galactosamineLys-LeuBestatinTelmisartan2-chloro-2',6'-diethylacetanilidePsychosineLysine(3s,6r,9s,12r,15s,18r)-3-butan-2-yl-4,10,16-trimethyl-6,9,12,15,18-penta(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexonePhenylacetaldehydeVerteporfin (visudyne)1,2-dilauroyl-sn-glycero-3-phospho-sn-glycerolAceroside viii5-heptenoic acid, 7-[(1r,2r,3s,5s)-2-[(1e,3s)-3-(2,3-dihydro-1h-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5z)-ClindamycinBufotalin6,8-dihydroxy-2,2,4,4-tetramethyl-7-(3-methylbutanoyl)-9-(2-methylpropyl)-9h-xanthene-1,3-dioneFosetylAminomalonic acidCoproporphyrin iiiSeleno-l-methionineChlorimuron ethylEnterostatin human3,4-Dihydroxy-L-phenylalanine(L-DOPA)1-(1,2-dioctanoylphosphatidyl)inositolFlunisolideL-propionylcarnitineProlintanePe 39:6All-trans-4-hydroxyretinoic acidUridine 5'-monophosphateNorethindrone 2,3,4-tri-o-acetyl-.beta.-d-glucuronide methyl esterPitavastatinNicardipineD-glucosamine 6-phosphate(2e,6e,11e,13e)-18-(2,6-dioxopiperidin-4-yl)-9-hydroxy-8-methoxy-10,12,14-trimethyl-15-oxooctadeca-2,6,11,13-tetraenoic acid[1,1'-biphenyl]-2-carboxylic acid, 4'-[[2,3-dimethyl-5-[[[(1s)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1h-indol-1-yl]methyl]-Gly-His-LysOleoyl ethylamide1,2-dioleoyl-sn-glycero-3-phospho-l-serineTrans-4-(aminomethyl)cyclohexanecarboxylic acidVeratramineO-methylatherolineDasatinib n-oxide(-)-hydroxycitric acid lactoneOctadecanoic acidPhe-Val1-(1z-octadecenyl)-sn-glycero-3-phosphocholineFenoldopamTolyporphin aLys-ProIndole-3-carboxaldehyde(2-aminoethoxy)[2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-[hexadec-1-en-1-yloxy]propoxy]phosphinic acid6-tert-butyl-3-methylsulfanyl-2h-1,2,4-triazin-5-oneNitrilotriacetic acidHomoharringtonineN-acetylneuraminic acid, 2,3-dehydro-2-deoxy-Met-Lys-ArgLeu-His-LysAdrenosteroneHexamethylcyclotrisiloxane(2r,3s,4s,5r,6r)-6-[1,7-bis(4-hydroxyphenyl)heptan-3-yloxy]-5-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-2-(hydroxymethyl)oxane-3,4-diolThymol-beta-d-glucoside2-(5-oxovaleryl)phosphatidylcholineZaleplonCarnitineHydroquinoneEuphorbiasteroidO-acetyl-l-serineCalycanthineCis-7,10,13,16-docosatetraenoic acidLys-TyrNaltrindoleDioctylamineAscochlorinL-dihydroorotate3-glucuronyl-22-ddmp soyasapogenol bGenistein4-ethoxybenzoic acidLuvangetinD-prolinePyrimethanilTestosterone enanthateHexosyl lpe 16:0Acetic acid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-TriptophenolideTri(propylene glycol) methyl ether1(2h)-pyrimidineacetamide, n-[(1s,3s,4s)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-.alpha.-(1-methylethyl)-2,4-dioxo-, (.alpha.s)-Lithocholylglycine15(s)-15-methylprostaglandin f2.alpha. ethylamidePhysostigmine1-hexanamine, 6-[4-(1h-imidazol-1-yl)phenoxy]-n,n-dimethyl-OfloxacinPamidronic acid7-methylguaninePs 39:6TroloxVal-metPc 34:1ErgocristineFenoxanilLys-Glu-Arg1-hydroxypyreneTrp-Asp-LysProbucolSer-Asp1h-indole-1-pentanoic acid, 3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-Trans-androsteroneGly-Pro-GluNelfinavirEprosartan4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acidAndrographolideHeroinThifensulfuron-methylValine conjugated chenodeoxycholic acidThr-Glu-LysPyridoxalIsoliquiritigeninHematoporphyrinDanazolAjmalicinePs 38:6ForskolinL-aspartic acid1,3,5(10)-estratrien-3,17.beta.-diol diglucosiduronateCytotrienin aThioetheramide-PCBenzenethiol, 4,4'-thiobis-Ps 44:12Pyrrole-2-carboxylic acidFenfluramine17alpha-hydroxyprogesteroneDL-glutamine.alpha.-ergocryptineQuinaldic acidDiethyl suberateDinor-12-oxophytodienoic acidNorrhizocarpic acidInosine 5'-monophosphateGeranylgeranyl pyrophosphateSecoisolariciresinol1,1-dimethyl-4-phenylpiperaziniumOlopatadine1-palmitoyl-2-linoleoyl-rac-glycerolEnniatin aEnniatin b1-stearoyl-2-docosahexaenoyl-sn-glycerolNeohesperidose3-aminoquinoline.alpha.-L-Glu-L-AspPro-leuCyclohexanesulfamic acidPantothenateMethanone, [1-(5-fluoropentyl)-7-hydroxy-1h-indol-3-yl]-1-naphthalenyl-Dl-a-hydroxybutyric acidHis-Arg-LysMevastatinMet-LeuHarringtonineDofetilide4-thiazolidinecarboxylic acid, 2-undecyl-, (4r)-L-ValineMyosminePi 36:5Pro-phePg 44:125-[(z)-14-(3,5-dihydroxyphenyl)tetradec-10-enyl]benzene-1,3-diolPepstatin aCuminaldehydeDifloxacinLeu-Lys-Arg2-hydroxyestradiolDiflunisalCytidine 5'-monophosphateCreatineGamma-glutamylleucinePro-Ala17,20-dimethylprostaglandin f1.alpha.BeauvericinPhenaceturic acidAsp-AsnL-homocysteic acid1-(4-hydroxy-3,5-dimethoxyphenyl)ethanone2-hydroxyatrazineBexaroteneGly-Leu-ArgCis-4,7,10,13,16,19-docosahexaenoic acidSm d34:1Asp-Arg4-nitrocatechol7(z),10(z),13(z),16(z),19(z)-n-(2-hydroxyethyl)docosapentaenamide3,4-dimethylbenzaldehydeAdipic acidDl-Leu-dl-Val2,6-diaminopimelic acidPimozideFolate1,4-d-xylobiose.alpha.-d-galactose 1-phosphateDibutyryl-cgmpAsn-Val-LysN-[(3s,5s,7s)-adamantan-1-yl]-1-(4-fluorobenzyl)-1h-indazole-3-carboxamideSalanninDl-octopamineIsoleucineHarmaline6-hydroxynicotinic acidPhosphatidylethanolamine2s-amino-4e-pentadecene-1,3r-diolThiouric acid3-(3,3-dichloro-2-hydroxypropyl)-6,8-dimethoxyisochromen-1-one1-[2,4,6-trihydroxy-3-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]phenyl]dodecan-1-oneDikegulac acidTubacin9h-xanthene-9-propanoic acid, .alpha.-amino-.alpha.-[(1s,2s)-2-carboxycyclopropyl]-, (.alpha.s)-Citraconic acidArg-ThrRifaximinSchweinfurthin eDL-Glutamic acidAndrastin cCyclobenzaprine n-oxideAndrastin a3-(n-maleimidopropionyl)biocytin7,2',3'-trimethoxyflavone.gamma.-l-glu-.epsilon.-l-lys2-amino-1-phenylbutaneMunduloneRabelomycinN-acetyl-d-lactosamineL-serine, n-(1-oxohexadecyl)-o-phosphono-RaltitrexedD-glucosaminic acidFenhexamidTrp-Pro-LysAndrastin d.beta.-estradiol 17-valeratePizotifene2-hexadecanoylthio-1-ethylphosphorylcholineDeoxyadenosineSufentanylIle-Gln-ArgN-Acetyl-D-Glucosamine 6-PhosphateOleana-1,9(11)-dien-28-amide, 2-cyano-3,12-dioxo-n-(2,2,2-trifluoroethyl)-3-methyladenineChikusetsu saponin 4a4-amino-5-chloro-1-phenyl-6-pyridazoneIsobergaptene4-chlorophenoxyacetic acid1-pentadecanoyl-sn-glycero-3-phosphocholine20-carboxyarachidonic acidGly-Ala-LysSer-Ala-LysMedicagenic acid base + o-hexDiethylcarbamazine2,4,6-tri-tert-butylanilineBergamotin3-methyl-2-quinoxalinone1-(3,4-dichlorophenyl)-3,3-dimethylurea5-hydroxy-6e,8z,11z,14z,17z-eicosapentaenoic acidLinoelaidic acidMethanone, [1-(4-hydroxypentyl)-1h-indol-3-yl](4-methyl-1-naphthalenyl)-11(12)-epoxy-5z,8z,14z-eicosatrienoic acidMagnololIsoformosanine2-methylpyrrolidine3-hydroxykynurenineKetamine.alpha.-pyrrolidinooctanophenoneCholineVal-ThrPro-Val-ArgAsparagine17-phenoxytrinorprostaglandin f2.alpha.Arg-Tyr-ArgPi 32:1TabersonineD-arabinonic acidHomatropineL-IsoleucineAdenylyl(3'-5')cytidineAsn-ArgOxcarbazepineAniline5-aminovaleric acid betaine.alpha.-guanidinoglutaric acidN.epsilon.-acetyl-l-lysineDaurisolineStrophantidinL-pipecolic acidIndole-3-pyruvic acidDecahydrogambogic acidGlu-Ser3-dehydrocarnitinePro-AspCer[ns] d34:1Resveratrol 4'-o-d-glucuronideVisnagin11.alpha.-hydroxyprogesterone .beta.-d-glucuronide1h-indole-1-pentanoic acid, 3-[(4-chloro-1-naphthalenyl)carbonyl]-2'-hydroxy-3,4,5-trimethoxychalcone3-methyloxyindolePyruvaldehydeSubsessilinePro-proDesferrioxamineLys-Met-Arg4'-o-.beta.-d-glucosyl-5-o-methylvisamminol2-Oxoadipic acidNitrazepam3-hydroxy-4-methoxycinnamic acidArg-Lys-LysLeucineOleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl esterMethyllycaconitinePyroglu-AlaArg-Pro-Arg1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 4,11-diethyl-4,9-dihydroxy-, (4s)-Val-GlnMifepristoneCurcumin16-phenyltetranorprostaglandin f2.alpha.Baicalin.beta.-acetyldigoxinPro-tyrPiperlongumineMonoelaidinAtazanavirThiamet gGlipizide10-nitrooleic acidPaclobutrazolLinolenic acidVitamin cN-acetyl-l-phenylalanine3-hydroxyxanthoneNorbuprenorphine1,2-dilauroyl-sn-glycero-3-phosphatidylcholinePhosphatidylcholine lyso alkyl 16:0LumazineOlanzapineDesmethylcerivastatin3,5-di-tert-butyl-4-hydroxybenzoic acid3,4,5-trimethoxyamphetaminePoricoic acid aEthylenediaminetetraacetic acidAspartameVerbenalinPe 42:10Manumycin aCortisol 21-sulfateMangostine1h-indole-5-carboxylic acid, 3-(2-methyl-1-oxopropyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-Ferulic acid ethyl esterProstaglandin i2Gln-Glu-ArgLys-ValVasicinoneAcetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-ParaoxonAngeloylgomisin hBiotinDL-tryptophanAmpicillinNeomycin1h-imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2- diphenylacetyl)-4,5,6,7-tetrahydro-, (6s)-MethylphenidateMyclobutanilFumagillinIngenolLys-Tyr-ArgN-acetyl-5-hydroxytryptamine2-methylhippuric acidL-methionineN,n-diethyltryptamineNeomenthyldiphenylphosphine oxideThiobencarbOleic acidEstriol1,2-di(4z,7z,10z,13z,16z,19z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamineBenzoic acid, 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-1,2-dimethoxy-4-(2-propenyl)benzeneVal-PheThr-Gly-ThrN-octanoyl-l-homoserine lactoneMelamineAnastrozolePropanoic acid, 2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methyl-Prostaglandin g2Tetrahydrogambogic acidKarakolineSer-SerPseudouridine1-palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolaminealpha-D-Galactose 1-phosphateL-homoarginineTurkesterone2'-o-methyladenosinePosaconazoleButorphanol5.beta.-pregnane-3.alpha.,17-diol-20-oneFumonisin py4Desacetyl (7)khivorinic acid, methyl ester2'-deoxyuridine 5'-monophosphateProtopine3-(methylthio)benzoic acidSinapyl alcoholTrimethoprim4-methylumbelliferyl .beta.-d-glucuronideD-glucuronic acidGlycyrrhizic acid3-amino-3-(4-hydroxyphenyl)propionate4'-benzyloxycarvedilol4-hydroxytriamterene sulfateBuspironeImatinibArenobufaginPro-Lys-ArgTebuconazoleLys-IleIsorhynchophyllinePc 39:6Geneticin6,7,3',4'-tetramethoxyisoflavoneFlumethasone pivalateSer-Glu-ArgFenuronArg-Phe-Lys[d-asp3,e-dhb7]-microcystin-rrPindololIsogentisin1-oleoyl-2-myristoyl-sn-glycero-3-phosphocholineArachidonoyl ethanolamide phosphateCoproporphyrin iCymarinSer-Ile-LysBeta-octylglucosideEthyl 4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylate9-hydroxycalabaxanthoneIsopentenyladenineIsoxanthopterinEthidimuronBeclomethasonePg 36:3D-xyloseBusseinTyr-Lys-Arg.gamma.-aminobutyric acidHuperzine bPhe-Ser-LysGlycochenodeoxycholateD-ribulose 5-phosphateThr-Ala-ArgHuperzine aN-(1,1-dimethyl-2-hydroxyethyl)-3-amino-2-hydroxypropanesulfonic acidDexanabinol1h-indazole-3-carboxamide, n-[(1s)-1-(aminocarbonyl)-2-methylpropyl]-1-(cyclohexylmethyl)-Phe-serTrans-2,3-dimethylacrylic acidOphiopogonin dCycloheximideAcetylcarnitineGlu-TrpArgininosuccinic acidDl-homocysteineMolassamideN-(phosphonomethyl)glycine3-(1h-indol-3-ylmethyl)-6,18-dimethyl-9-(2-methylpropyl)-12-(1-phenylethyl)-15-propan-2-yl-1,4,7,10,13,16,19-heptazacyclotricosane-2,5,8,11,14,17,20-heptone1,2-bis(heptanoylthio) glycerophosphocholineTrihexyphenidylAsn-Val-ArgMannose2,4-diaminobenzenesulfonic acid3-hydroxystanozolol glucuronideZanamivirN-glycolylneuraminic acidOphthalmatePhloretinLeu-Ala9-cis-retinal15-deoxy-.delta.12,14-prostaglandin j2 glutathioneFingolimodLopinavir5-azacytidineNorfloxacin.alpha.-hederin1-(1z-hexadecenyl)-sn-glycero-3-phosphocholineThr-ThrInabenfideAmoxicillinCalpain inhibitor iiTyr-Thr-LysGlutamic acidP-toluenesulfonic acidIvacaftorValsartan5,6-dihydroxyindole-2-carboxylic acidMet-Leu-ArgAsn-Gly-LysDefluoroatorvastatin18.beta.-glycyrrhetic acid methyl esterProsapogenin aN-cyclohexylaniline1-monolinoleoyl-rac-glycerol1-octadecyl lysophosphatidic acidPrunasinRetinenePerillaldehydeBradykininAlpha-ketoisovaleric acidDeoxykhivorinProsulfocarbHis-GluDexpanthenolNocardamineSer-Gly-SerN-(2-aminoethyl)-5-isoquinolinesulfonamideArachidonoylthiophosphorylcholineDiacetylPiriprostScutellareinCyproheptadineOxethazaineN-palmitoyl-d-sphingosine7-hydroxyfluphenazineGibberellic acidL-leucyl-l-leucine methyl esterArachidonoyl ethanolamideThr-GluDecamethylcyclopentasiloxaneAcetaminophen sulfateNeobavaisoflavoneAmphotericin bBetaine5-(2-hydroxyethyl)-4-methylthiazoleL-AlanineTomatineD-erythro-imidazolylglycerol phosphate4-methyl-3-nitrobenzoic acid1-(5z,8z,11z,14z-eicosatetraenoyl)-sn-glycero-3-phosphoserineGomisin cPyrrolidinium, 1-[(7r)-7-(acetyloxy)-4-hydroxy-4-oxido-3,5,9-trioxa-4-phosphapentacos-1-yl]-1-methyl-, inner saltKanamycin a4,4'-thiodiphenolPe 38:6PlatensimycinCytidineEnrofloxacinOctyl .alpha.-ketoglutarateNonanamide, n-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]-8-methyl-HomostachydrineMorphine-3-glucuronide3beta,7alpha-dihydroxy-5beta-cholan-24-oic acidAlfuzosinProstaglandin j2Alfentanyl4-methylbenzyl alcoholHydrocortisoneSer-Val-ArgGenipinVirginiamycin component bHis-ThrPalmitamidePhytolaccasaponin GStrychnineTrioxsalenGlutathione, oxidizedAnorexigenic peptideSer-Asn-LysCalusteroneHexanoyl-l-carnitineQuinate19-hydroxyandrost-4-ene-3,17-dioneHis-Lys-Arg2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine4-imidazoleacetic acidTrp-Lys5,7-dihydroxy-2-phenyl-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-(3,4,5-trihydroxyoxan-2-yl)chromen-4-oneAllantoinSpiroxamine12:4+3o fatty acyl hexosideLeu-Asp-LysFormylanthranilic acidRiluzoleOrsellinic acidTandutinib7-(triethylsilyl)-10-deacetylbaccatin iiiD-Ribose 5-phosphateGamma-l-glutamyl-l-glutamic acidBlood group a trisaccharideBenzo[h]quinoline-3-carboxylic acid, 1,4-dihydro-4-oxo-PhosphoenolpyruvateGitoxinGlu-Thr-LysArctigeninCytidine 5'-diphosphocholineGly-LeuCastanospermineCytisine1-stearoyl-rac-glycerol2-naphthalenesulfonic acid2'-deoxycytidineCortisol 21-acetate2'-deoxycytidine 5'-monophosphateFostriecinCholesteryl sulfateOsajin5-azauracil.beta.-alanine, n-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl)-4-pyrimidinyl]-BrimonidineL-citrullineHexosyl lpe 18:3LariciresinolPentadecanoic acidCoenzyme q24-ohe2-1-n3ade4-heptenoic acid, 7-[(1r,2r,5s)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-, (4z)-rel-L-threonineD-leucinamide, n-[(phenylmethoxy)carbonyl]-l-leucyl-n-[(1s)-1-formyl-3-methylbutyl]-Val-Asp-Arg(+)-catechin2'-hydroxy-4-methylchalcone7.alpha.,17.alpha.-dimethyl-5.beta.-androstane-3.alpha.,17.beta.-diol glucuronidegamma-Glutamyl-L-methionineChrysomycin aL-leucyl-l-proline1,4-bis[(p-hydroxyphenethyl)amino]anthraquinoneIndolelactic acidIle-Pro-Ile3-[(3s,5r,10s,13r,14s,17s)-14-hydroxy-3-[(2r,3s,4s,5s,6s)-3-hydroxy-4-methoxy-6-methyl-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyoxan-2-yl]oxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2h-furan-5-oneTaurocholateMyristamine oxideMaltotetraose(2s,3r,5r,10r,13r,14s,17s)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2r,3r,5r)-2,3,6-trihydroxy-5,6-dimethylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-6-oneHarmineDehydrocholic acidStreptomycin aPro-hypFluvastatinHarpagosideLeu-Gln-ArgGallic acid2-[[5-[[2,12-dihydroxy-4,4,10,13,14-pentamethyl-17-(1,5,6-trihydroxy-6-methylheptan-2-yl)-2,3,5,6,7,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-3-hydroxy-3-methyl-5-oxopentanoyl]amino]acetic acidLys-AlaMyristic acidHypoxanthineIndomethacinPhenyllactic acidTriadimefon1-palmitoyl-2-myristoyl-sn-glycero-3-phosphocholineGly-Trp16.alpha.-hydroxyestroneAsp-Lys-LysAsp-Pro-Arg1-oleoyl-sn-glycero-3-phosphocholineN-stearoylsphinganineEnniatin b1[6]-shogaolL-homocitrullineCytarabineHamamelitannin(+)-11-nor-.delta.9-tetrahydrocannabinol-9-carboxylic acid glucuronide4-(3,5-dimethyl-4h-1,2,4-triazol-4-yl)piperidineNateglinidePhenylacetyl-l-glutamineCaftaric acidGardenin bAdenineChlorogenic acidN-acetyl-l-tyrosine(4e,8e)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1h-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoic acidGly-PheHydroquinidineDidanosineIle-ArgGalacto-n-biose2-aminoethylphosphonic acidEbastine2,5,7,8-tetramethyl-2-(.beta.-carboxyethyl)-6-hydroxychromanQuinacrine7-ethyl-10-(4-n-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecinGartaninPipamperoneCucurbitacin iMedroxyprogesterone 17-acetateCholic acidCucurbitacin dCucurbitacin e2'-Deoxyinosine 5'-monophosphateCytidine monophosphate n-acetylneuraminic acidCucurbitacin bLeptomycin b2-methoxy-3,5-dimethyl-6-[(4z)-4-[(e)-2-methyl-3-(4-nitrophenyl)prop-2-enylidene]oxolan-2-yl]pyran-4-oneProstaglandin f2.alpha.Ethyl 8-fluoro-4-hydroxyquinoline-3-carboxylateBenzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-[4-(cyclohexyloxy)butoxy]phenyl]propoxy]-L-valinamide, n-(4-methoxy-1,4-dioxobutyl)-l-alanyl-l-alanyl-l-prolyl-n-(4-methyl-2-oxo-2h-1-benzopyran-7-yl)-1-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)MaltotriosePolygalic acidProstaglandin a2Dichlormid2,4,6-trichlorophenolAconitineOpipramolHomocitrateLinustatinLeu-Glu-LysVeratridineMaslinic acidN-methyltyramineGambogic acidPro-val17-trifluoromethylphenyltrinorprostaglandin f2.alpha. ethylamide(e)-n-[2-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[2-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-13-methyltetradec-2-enamide2-[3-[(e)-6-acetyloxy-2-hydroxy-6-methyl-3-oxohept-4-en-2-yl]-6-(carboxymethyl)-2-hydroxy-3a,5a,9b-trimethyl-5-oxo-2,3,4,6,9,9a-hexahydro-1h-cyclopenta[a]naphthalen-7-yl]-2-methylpropanoic acidSaponarinGln-Ala-LysBenzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]-4-hydroxycyclophosphamideNisoldipine4-nitrosodiphenylamineL-palmitoylcarnitineDeoxyguanosineTrp-Val-LysTrans-aconitic acidMycophenolic acid phenolic .beta.-d-glucosideMethylprednisolone succinateOctanediamide, n1-hydroxy-n8-[4-[4-[(1-oxo-5-hexyn-1-yl)amino]benzoyl]phenyl]-D-2-aminobutyric acid2-aminophenolD-neopterin(S)-2-aminobutyric acidNaproxen1-amino-2-ethoxybenzene1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholineEstriol 16alpha-(beta-d-glucuronide)Chrysosplenetin1-o-hexadecyl-2-deoxy-2-thio-s-acetyl-sn-glyceryl-3-phosphorylcholineAndrosterone sulfateLtc4-[d5]2,6'-dimethoxy-2'-hydroxychalconeOmethoateTerragine eDixyrazine4-[[4-hydroxy-2-(2-methylpropyl)-1-oxo-3,3a-dihydro-2h-imidazo[1,2-a]indol-4-yl]methyl]-1-methyl-2,4-dihydro-1h-pyrazino[2,1-b]quinazoline-3,6-dioneMethanesulfonamide, n-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-OrcinolPodocarpic acidProtoporphyrin ix(r)-butyrylcarnitine17.beta.-nandrolone decanoateN,n,n-trimethyllysineOxycodoneAllantoic acidBenzoylmesaconineD-glucose 6-phosphate7-demethylsuberosinGly-TyrLappaconitineCarbenoxolone1-docosahexaenoyl-2-stearoyl-sn-glycero-3-phosphocholine1-heptadecanoyl-sn-glycero-3-phosphocholine1-acetylimidazolePomiferinPyrrolidine3-deoxy-d-glycero-d-galacto-2-nonulosonic acidSuccinic acid n,n-dimethylhydrazideDL-serineTerfenadine3'-AMPS-(2-boronoethyl)-l-cysteineImazethapyrActinonin4''-trans-hydroxycilostazolAla-Glu-LysSynephrineN-acetylhistidineTobramycinHydroxyebastine2,3,4',5-tetrahydroxystilbene 2-glucosidePhenylpyruvate2-docosahexaenoyl-1-stearoyl-sn-glycero-3-phosphoethanolamineIle-ThrSalmeterolAgaric acidArg-cysIsethionate[2,3-dihydroxy-1-(7-methoxy-2-oxochromen-6-yl)-3-methylbutyl] (z)-2-methylbut-2-enoateNormorphine5-methylbenzotriazoleLasalocidCoumatetralylMonensinD-erythro-sphingosine-1-phosphateImazapyrThr-Val-ArgProthioconazoleAla-Val-Lys4-androsten-17.beta.-ol-3-one glucosiduronateTyr-Asn-ArgBrassicasterolLipoxin a4PyrantelDemethoxycurcumin4-ohe2-1-n7guaArginine1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol)SilybinLys-Glu-LysSer-GluGlutathione(.+/-.)-cromakalim1,2-dimethylimidazoleLeucylleucineLeu-Ala-ArgRoquefortine cL-carnitineFexofenadineLeu-Gly-LeuMethanone, [1-(5-fluoropentyl)-6-hydroxy-1h-indol-3-yl]-1-naphthalenyl-IsophoronePc 36:2Pc 36:5OleamideDioscinMethylergonovineHeliotrineIle-Trp-LysPro-GluProscillaridin aGlu-Phe-Lys1h-indole-1-pentanoic acid, 3-[[[1-(aminocarbonyl)-2,2-dimethylpropyl]amino]carbonyl]-DL-arginineAlisol a 24-acetateGln-tyrMetamitronSer-Ala-Arg3-methyl-2-oxopentanoatePipemidic acidThr-Thr-Arg6-[(3e,6e)-2,5-dihydroxy-4,6-dimethyl-7-(1,2,4-trimethyl-3,6-dioxabicyclo[3.1.0]hexan-4-yl)hepta-3,6-dien-2-yl]-4-methoxy-3,5-dimethylpyran-2-oneImazaquinCanthaxanthinArg-Arg21-carboxylic acid triamcinolone acetonide1h-indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-n-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-5-chloro-2,4-dihydroxy-6-methyl-3-[(e)-3-methyl-5-[(1s,2r,6r)-1,2,6-trimethyl-3-oxocyclohexyl]pent-2-enyl]benzaldehydePyraclonil14-o-acetyldaunomycinoneThr-Ile-LysBenzyl alcoholAcetylanilineL-threonateL-saccharopineAsp-Leu-ArgAzamethiphosTetrodotoxin1-o-hexadecyl-2-o-(5z,8z,11z,14z,17z-eicosapentaenoyl)-sn-glyceryl-3-phosphorylcholine11-(dansylamino)undecanoic acid5-aminovaleric acid1,2-dimyristoyl-sn-glycero-3-phosphate1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol)Asp-Glu-ArgLeu-Ile-Arg[(2r,3r,4s,5s,6r)-3-acetyloxy-2-(acetyloxymethyl)-5-hexanoyloxy-6-[(2s,3r)-2,3,4-trihydroxybutoxy]oxan-4-yl] 14-hydroxytetradecanoateGlu-Glu-ArgKarbutilateTrandolapril1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-.alpha.,.alpha.- dimethyl-5-(1-methylethyl)-1h-indole-2-propanoic acidTyr-Glu3,7-Dimethyluric acidGlu-MetOligomycin b3-ketofusidic acidMelphalanThiopentalN.epsilon.-methyl-l-lysineFraxetinCyclopentolateThr-Asp-Lys(3r)-5-methyl-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[[4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methoxycarbonyl]hexanoic acidUric acidN-(2-hydroxyethyl)-8(9)-epoxy-5z,11z,14z-eicosatrienamideCyclopiazonic acidPterostilbeneAlisol b acetateMyristoyl ethanolamideDL-threonineCyanidin 3,5-diglucoside(-)-secoisolariciresinol3,5,9-trioxa-4-phosphatetracosan-1-aminium, 7-(acetyloxy)-24-carboxy-4-hydroxy-n,n,n-trimethyl-, inner salt, 4-oxide, (r)-7-benzyl-11,14,20-trimethyl-16-(2-methylpropyl)-10,13-di(propan-2-yl)-17-oxa-1,5,8,11,14-pentazabicyclo[17.3.0]docosane-2,6,9,12,15,18-hexoneTrp-GluSisomicin2-hexenal4-aminovaleric acid betainePC(16:0/16:0)ResazurinPicric acid2-hydroxylamino-4,6-dinitrotolueneValerylfentanylBatimastatNatamycinTetrandrineKinopreneThr-Lys3',4'-methylenedioxyorobolCarpropamidAcyclovirUridine 5'-diphosphoglucuronic acid (UDP-D-glucuronate)N1-losartanyllosartanMet-Trp-LysAcetaminophen1-oleoyl-l-.alpha.-lysophosphatidic acidSclareolide5-methylcytosineL-kynurenineLupuloneCabergolineO-phosphoethanolamineTrh, free acid1-heptanone, 1-(4-methoxyphenyl)-2-(1-pyrrolidinyl)-1,3,4,6,7,8-hexahydro-2h-pyrimido[1,2-a]pyrimidineLys-AspRosuvastatinMeperidineLatrunculin aRifampicinS-methyl-5'-thioadenosineGlu-Leu-ArgUdp-n-acetylglucosamineLontrel4',5,7-trihydroxy 3,3',6,8-tetramethoxyflavoneThalsimidine2-amino-1-phenylethanolThr-Leu-ArgAsn-Phe-ArgEriodictyol1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholineMyo-inositol4,6-dinitro-o-cresolXanthosine3-formylrifamycinGlu-ValIsoxabenLithospermic acidMyriocinO-desmethylmycophenolic acidTebufenpyradLys-Arg5,9-dihydroxy-5,7,7-trimethyl-4,5a,6,8,8a,9-hexahydro-1h-azuleno[5,6-c]furan-3-oneSpinosineNorcodeine7-hydroxy-4-methylcoumarin-3-acetic acidGln-Thr-LysPg(18:1/8,9-eet)Gln-Arg-ArgFlufenacet ethanesulfonic acidGlu-Val-ArgBenzamide, 3-(dimethylamino)-n-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-Tauroursodeoxycholic acidMilrinonePravastatinGlycocholic acidGlycocholateChenodeoxycholateAsp-Met-ArgBisphenol aGanciclovir1-(1,2-dihexadecanoylphosphatidyl)inositol-3-phosphateBuprenorphine glucuronideAla-ProGlutethimide2,6-dihydroxy-7-methoxy-1,1,4a-trimethyl-3,4,10,10a-tetrahydro-2h-phenanthren-9-one1.alpha.-methyl-5.alpha.-androstan-3.alpha.,17.beta.-diol glucuronide8z,14z-eicosadienoic acidDibutyl adipatePioglitazone2-propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1h)-isoquinolinyl)-3-(1-methyl-2-phenyl-1h-pyrrolo[2,3-b]pyridin-3-yl)-S4:17(p3:15/f1:2)DL-isoleucinePro-ThrDehydroascorbic acidL-cystathionineNifekalant2-hydroxy-2-methylbutyric acidApramycinDeoxythymidine 5'-phosphate (dTMP)HexythiazoxPhenol, 4-[[4-(4-morpholinyl)butyl]thio]-Asn-ThrDjenkolic acidGuanidinoethyl sulfonate4-imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-Pleiokomenine aAdenosine 5'-phosphosulfate4,5-epoxy-7z,10z,13z,16z,19z-docosapentaenoic acid, methyl esterBazedoxifeneTaurochenodeoxycholateMacluraxanthoneMethylphosphonothioic acid o-ethyl esterPyroglu-HisOleanane -2h, +1o, 1cooh, o-hexa-hexaHis-LysHis-serMontelukast-1,2-diolGly-pro-arg-pro-amide1-hexadecanoyl-2-sn-glycero-3-phosphateN-.alpha.-(tert-butoxycarbonyl)-l-glutamic acidBenzeneacetamide, n-[[[4-(5,9-diethoxy-6,8-dihydro-6-oxo-7h-pyrrolo[3,4-g]quinolin-7-yl)-3-methylphenyl]methyl]sulfonyl]-2-methoxy-DobutamineCytidine 3'-monophosphateBiocytin17-phenyltrinorprostaglandin e2 serinolamideSpirotetramatGossypinSarcosinePc 44:12Mexicanolide5a,6-anhydrotetracyclineTaurineAmastatin4-hydroxy-4'-chlorobiphenylHydrangenoside cSulfosuccinimidyl oleate4-hydroxyatorvastatin lactone3-hydroxy-3-methylglutaric acid1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholinePc 40:7AgmatineEpothilone bVinblastinePe 36:1Gln-gluHis-PheGlycerolAscomycinStylopinePe 36:5Deoxynivalenol-3-glucosideGarcinol(-)-atropineTopiramateIsohernandezineArtemisininGanoderic acid hN-demethylerythromycinGanoderic acid f2,6-di-tert-butylpyridineIrisxanthoneGly-Gly-LysGanoderic acid aArg-Leu-ArgVal-IleGentisic acid1,2-dioleoyl-sn-glycero-3-phosphate3-dehydroepiandrosterone sulfate.beta.-cyano-l-alanine1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine (SOPC)Oleoyl-l-carnitinePiperonyl butoxideIsocorynoxeineFerrichromeErythromycylamineSer-Trp-ArgN-acetylaspartylglutamic acidLstaPentaethylene glycolL-alaninamide, n-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-l-alanyl-5-aminoorotic acid7-methyluric acid(2s,3r,5r,10r,13r,14s,17s)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2r,3r)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-6-oneSarafloxacinDomoic acidUracilAmprenavir2-docosahexaenoyl-1-stearoyl-sn-glycero-3-phosphoserineWithaferin aQuinaprilTrp-Trp1-tetrahydro-2h-pyran-4-yl-4-piperidinamineMorphineOstruthinAsp-TyrOfloxacin n-oxideCytosineN-[3-[5,17-bis[3-[acetyl(hydroxy)amino]propyl]-14-benzyl-8-(hydroxymethyl)-11-(2-methylpropyl)-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexazacyclooctadec-2-yl]propyl]-n-hydroxyacetamide17-phenyltrinorprostaglandin a2His-Val-Arg(1-(5-fluoropentyl)-1h-indazole-3-carbonyl)-l-valine2-naphthalenol, 1-[(2,4-dimethylphenyl)azo]-N-(2-phosphate-1r-methylethyl)-5z,8z,11z,14z-eicosatetraenamide7-benzyl-11,14-dimethyl-16-(2-methylpropyl)-10,13-di(propan-2-yl)-17-oxa-1,5,8,11,14-pentazabicyclo[17.3.0]docosane-2,6,9,12,15,18-hexoneMethylphosphonic acidMalateMet-ArgCarvedilolBeclomethasone dipropionateHerbacetin4-amino-2,6-dinitrotoluene1h-1,2,3-triazole-1-octanamide, n-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-Adenosine 5'-diphosphateEnterolactoneLomefloxacinBenzoylnorecgonine2-methoxy-5-nitrophenol1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-l-serineVal-ValRescinnamineSkullcapflavone iiVincamine1h-indole-4-carboxamide, n-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1s)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-Trp-Trp-Arg2-pyrrolidinone, 1-methyl-IndinavirHis-TrpTelaprevir (vx-950)Codeine-6-.beta.-d-glucuronidePyruvateNeotameD-arabinose(3r,7r,9s,10s,12s,13r,14s,17r)-17-((2r)-6,7-dihydroxy-6-methylheptan-2-yl)-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthrene-3,7,12-triolGln-thrHeptadecanoic acidCdp-ethanolamineAsp-Gly-ArgCyromazinePhenanthridineMyriocin-12-enPi 38:5Pro-TrpGlutaminePalmitic acidTrp-LeuHistidineSer-Ser-ArgGlycyl-l-norleucineValidamycin aPuberanidineD-aspartic acidPhosphoric acid1,3-cyclobutanedicarboxylic acid, 2,4-diphenyl-, 1-(1-naphthalenyl) ester, (1.beta.,2r,3.alpha.,4r)-Propionic acid7,8-dihydroneopterinRutamarinAlpha-chaconineNe-acetyllysinePhe-Val-Arg9-oxo-11.alpha.,16r-dihydroxy-17-cyclobutyl-5z,13e-dien-1-oic acidBrompheniramineGatifloxacinOkadaic acidGlycerophosphocholine[(2r,3r,4s,5s,6r)-3-acetyloxy-2-(acetyloxymethyl)-5-hexanoyloxy-6-[(2s,3r)-2,3,4-trihydroxybutoxy]oxan-4-yl] tetradecanoateDL-phenylalanineActinomycin dDl-lactateGlimepirideAmikacinMethanone, (6-hydroxy-1-pentyl-1h-indol-3-yl)-1-naphthalenyl-Retrorsine n-oxideDosulepin2-naphthalenecarboxamide, n-[(1s)-2-[4-(5-chloro-2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholinePropazineDipivefrineThr-Leu2-(4-chlorophenyl)-1-(2,4,6-trihydroxyphenyl)ethanoneMicrocystin lr.alpha.,.alpha.'-trehalose 6-phosphate(r)-(+)-arachidonyl-1'-hydroxy-2'-propylamideEdaravoneNoreugenin.beta.-glycerophosphate1h-pyrazole-3-carboxamide, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-n-[(1s,2s,4r)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-Lys-SerXanthineEtobenzanidCordycepin3-isoxazolecarboxamide, 5-(5-chloro-2,4-dihydroxyphenyl)-n-ethyl-4-(4-methoxyphenyl)-His-LeuSchizandrinBeta-D-Fructose 2-phosphateL-gulono-1,4-lactone2-acetyl-6-[(3-butanoyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-oneDocosahexaenoylserotonin4-Aminobutyric acid(GABA)Glu-LysFlavanone.delta.-hexalactoneAldosterone5-isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl esterIndirubin-3'-monoxime1,3-propanediol, 2-amino-2-[2-(3-azido-4-octylphenyl)ethyl]-Maleic acidVal-Val-Arg1,2-didocosahexaenoyl-sn-glycero-3-phosphocholineAla-LysIndoxyl sulfatePhosphorylcholineChlormadinone acetateTrp-CysFluphenazineSolasodineIndole-3-butyric acidEchimidineN-acetyl-d-glucosamineAngiotensin i human2'-deoxyinosineSarsasapogeninHis-TyrHetisineVitamin k17-hydroxy-4z,8e,10z,13z,16z,19z-docosahexaenoic acidLauryldimethylamine oxideLuffariellolideCitalopram1',4-sophorolactone 6',6-diacetate1-methyl-l-histidineDesferrioxamine d215(r)-methylprostaglandin a2Aminomethylphosphonic acidDihydralazine(2r,3s,4as,7r,8r,8as)-2,3,4'-trihydroxy-4,4,7,8a-tetramethylspiro[2,3,4a,5,6,7-hexahydro-1h-naphthalene-8,2'-7,8-dihydro-3h-furo[2,3-e]isoindole]-6'-onePiperidine3-oxazolidinecarboxylic acid, 2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-, 1,1-dimethylethyl ester, (4s)-6-benzylaminopurine2-aminoadipic acidPrometryneHis-ProN-lauroyl-d-erythro-sphingosylphosphorylcholine.beta.-estradiol 3,17-dipropionateCis-4-hydroxyprolinePhosphocholineXylitolDocosatetraenoyl ethanolamideAlitameCarminic acid1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate)(-)-.alpha.-kainic acidSorbitol 6-phosphateBecatecarinAcenapthylene2'-deoxyadenosine 5'-monophosphateL-bunolol1-stearoyl-2-hydroxy-sn-glycero-3-phosphatesn-Glycerol 3-phosphoethanolamineIle-LysEchinacoside1,2,4-benzenetriolDictamineProstaglandin f1.alpha.Deoxyinosine5-hydroxymethyl-2-furancarboxylic acid.alpha.-apooxytetracyclineEchimidine n-oxideAcetic acid, 2-(2,4,6-trichlorophenoxy)-, (2e)-2-(1h-pyrrol-2-ylmethylene)hydrazide7-hydroxycoumarin-3-carboxylic acidTriflumuronO-Succinyl-L-homoserineNevadensinAminocyclopyrachlor6,7-dihydroxycoumarin-4-acetic acidD-glucosamine 1-phosphateHydroxyflutamideTropinonePaxillineVincamoneDeoxynojirimycin tetrabenzyl etherPheophorbide aL-glutathione, reducedThr-Gln-ArgNCGC00347372-02Kukoamine aIndirubinDelta4-dafachronic acidProfluralinGlycineKukoamine bLicoricesaponin h2Val-AlaPg 34:1.beta.-alanine, n-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl)-4-pyrimidinyl]-1-arachidoyl-2-hydroxy-sn-glycero-3-phosphocholineGlu-ArgGlutaric acidN-acetyl-l-aspartic acidPyroglu-tyr-argAstilbin2-(4-amino-1-piperidinyl)acetamide7-(2-aminopropyl)benzofuranDecanoyl-l-carnitine5-hydroxyflavoneFenpropidinMls000863654-01!LuminespibPentazocineAcetylvanillinRamelteon6-phosphogluconic acidBetulinic acidD-(+)-galactoseMet-Tyr-ArgMycophenolate mofetil5-aminolevulinic acidTrp-his10-formyl-7,8-dihydrofolic acidGambogenic acidCitrateDoxorubicinOctanoylcarnitineG-guanidinobutyrateVal-Glu-LysGlyceric acidPs 40:6N-acetyl-l-glutamateCandesartan cilexetilForsythoside aBiliverdinCytochalasin eL-norvalineCytochalasin aCytochalasin bPalmitoyl sphingomyelin(1s,4as,7s,7as)-7-hydroxy-7-methyl-1-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[(4-hydroxybenzoyl)oxymethyl]oxan-2-yl]oxy-4a,5,6,7a-tetrahydro-1h-cyclopenta[c]pyran-4-carboxylic acidPenicillic acidFlavanone hydrazoneUridineCyproconazoleImazamoxEnterodiolMianserin n-oxideTrans-zeatinN6-methyl-l-lysinePhe-met-arg-phe-amide1-(1z-octadecenyl)-2-(4z,7z,10z,13z,16z,19z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamineIcaritinPyripyropene a1-palmitoyl-2-oleoyl-phosphatidylglycerolNintedanibGly-Leu-LysN-myristoylsphinganine11,12-methylenedioxykopsinalineThr-AlaTestosterone cypionateLpe 18:2Tyr-His-ArgSwainsoninePro-His-ArgUdp-d-glucoseAsn-Leu-LysL-Ascorbic acidCochlioquinone a3,4-dihydroxymandelic acidBafilomycin a1Dehydroaripiprazole8s-hydroxy-5z,9e,11z,14z-eicosatetraenoic acidMet-Met-ArgErgocristamLevofloxacinUrapidilPropentofyllineTrp-Val-ArgN-acetyl-l-methionineTrachelanthineCinnamyl 3,4-dihydroxy-.alpha.-cyanocinnamate15(r),19(r)-hydroxyprostaglandin f1.alpha.2-acetamido-2-deoxy-3-o-(.alpha.-l-fucopyranosyl)-d-glucopyranosePhe-Gln-LysStrictosidineDiphenoxylate3-[(cholamidopropyl)dimethylammonio]-1-propanesulfonateSulfobacin b1-Stearoyl-sn-glycerol 3-phosphocholineHarmalol1h-indole-3-carboxylic acid, 1-(cyclohexylmethyl)-2-[2-[19-acetamido-6-(3,4-dicarboxybutanoyloxy)-16,18-dihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic aci4-aminoantipyrine(-)-riboflavinCephaelineApicidinBenzoic acid, 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-11-dehydrothromboxane b2DovitinibArctiinRauwolscine3-o-acetyl-16alpha-hydroxytrametenolic acidNCGC00381123-01PerindoprilTrimethylamine n-oxideSer-Leu-ArgGibberellin a91-hexadecyl-sn-glycero-3-phosphocholineSuberic acidGibberellin a41,24-dihydroxyvitamin d3VincanidineDihydroergocristineLauroyl-l-carnitinePropanoic acidLeu-Glu-Arg1h-indole-6-carboxamide, n-hydroxy-1-[(4-methoxyphenyl)methyl]-3,5-dimethoxy-4-hydroxycinnamic acidN-(2-furoyl)glycineD-psicose3-deacetylsalanninCis-10-heptadecenoic acid1h-indole-1-pentanoic acid, 3-[(4-methyl-1-naphthalenyl)carbonyl]-Gly-Trp-LysPg 38:6CreatininePrimisulfuron-methylTyr-Trp-LysPentanoic acid, 5-[(3ar,4r,5r,6as)-3,3-difluorohexahydro-5-hydroxy-4-[(1e,3s,4s)-3-hydroxy-4-methyl-1-nonen-6-ynyl]-2h-cyclopenta[b]furan-2-ylidene]-, (5z)-Cycloxydim-tp bh 517-tso e/z-isomerN-.alpha.-acetyl-l-ornithine3-(n-morpholino)-2-hydroxypropanesulfonic acid1,2-diamino-2-methylpropaneRoseoflavinRifabutinSwertisinD-2-phosphoglyceric acidAstaxanthinAlizarin yellow ggHeptanedioic acid, 1-[2-[(2-carboxyphenyl)methylene]hydrazide]Resveratrol 3-o-d-glucuronideIndanofanSn-glycerol-3-phosphoethanolamineCinobufaginGamma-glu-gluTenofovir4-aminophenolUrobilin2-cis-4-trans-abscisic acidTropisetronLeukotriene d4 methyl esterAla-Glu-Arg3-[1-[3-(dimethylamino)propyl]-5-methoxy-1h-indol-3-yl]-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dioneAsn-Lys5-hydroxy-l-tryptophan1-palmitoyl-2-lauroyl-sn-glycero-3-phosphorylcholineButanamide, n-[(3s,5s)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-n-[(3-methoxyphenyl)methyl]-3,3-dimethyl-BorrelidinAtorvastatin3-amino-2,3-dihydrobenzoic acidTrp-Ile-LysN-acetylneuraminic acidBupirimateImazamethabenz-methylDimethylbenzimidazoleBetamethasone 17-valerateCaffeateVal-Val-LysUridine 5'-diphosphateD-mannose 6-phosphateTris(2-butoxyethyl) phosphateArg-Ile11,14,17-eicosatrienoic acid, (z,z,z)-YunaconitineMetolachlor oaGly-SerL-pyroglutamic acid2-thiophenecarboxylic acidBifenox1-linoleoyl-2-oleoyl-rac-glycerol1-o-hexadecyl-2-o-(4z,7z,10z,13z,16z,19z-docosahexaenoyl)-sn-glyceryl-3-phosphorylcholine2-heptyl-4-hydroxyquinoline n-oxideNudifloramide1-(2,4-dihydroxyphenyl)-2-(3,5-dimethoxyphenyl)propan-1-oneVal-Gly-ValDichlorpropCys-GlnNaringeninEmbelinXanthohumol1,2-dilauroyl-sn-glycero-3-phosphoethanolamine1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4'-bisphosphate).delta.17-6-ketoprostaglandin f1.alpha.RhynchophyllineThiamine monophosphateSuccinateAsn-Ala-LysNg,ng-dimethyl-l-arginineLeukotriene f4PentamidineMaresin 12-amino-4,6-dihydroxypyrimidine5(s),14(r)-lipoxin b4Methanone, [1-(5-hydroxypentyl)-1h-indol-3-yl](4-hydroxyphenyl)-OleuropeinPseudojervineAlbiflorinD-myo-inositol-3,4,5,6-tetraphosphateSubstance p (9-11)SirolimusRicinoleic acidCelastrolCys-CysPrilocaineLeukotriene e4Hyperforin2'-chloro-2-hydroxy-5-methylbenzophenoneResiniferatoxinLincomycinIle-Pro6.beta.-naltrexol6-quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-ShikimateN-(.alpha.-benzylphenethyl)formamideCnicinNiacinamideN-arachidonoyl-3-hydroxy-.gamma.-aminobutyric acidK-strophanthosideKojic acidNordihydroguaiaretic acid2-propylphenolGalactinolPenciclovir7.alpha.-hydroxy-4-cholesten-3-one1-palmitoyl-2-azelaoylphosphatidylcholineLeukotriene d4Osthole4-hydroxyvalsartanNorisoboldineEstrone glucuronideHc toxinCrotamitonN-acetyl-l-carnosineLeukotriene c4Umbelliferyl arachidonateLeukotriene b4 3-aminopropylamideEvodinBradykinin fragment 2-91-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholineTuberostemonineNorleucineCannabidiolic acidFumitremorgin cDiclosulamGossypolTriamcinolone diacetatePhytosphingosineBisindolylmaleimide iCysteine conjugated chenodeoxycholic acidFormoterolValerenic acidPropranololTyrosineMibefradilProtostemonineIle-LeuO-phosphotyrosineCinidon-ethylDrofenineNorbuprenorphine glucuronideL-Malic acid1-palmitoyl-sn-glycero-3-phosphocholineHydroxychloroquineCorticosterone 21-acetateSepiapterin11-ketofusidic acid6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6s)-Linamarin1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamineMethimazoleD-glutamine15-ketofluprostenol isopropyl esterPlatencinAdenosine 2'-monophosphateLeu-PheAndrostan-3-ol-17-one 3-glucuronideMucic acidNeopentyl glycol(S)-2-HydroxyglutarateD-pipecolinic acidPristimerin5-fluorouridineShikonin1-oleoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol)Sungucine1,2-dihexadecanoyl-sn-glycero-3-phosphocholineNicotinate d-ribonucleotideN-acetylglucosaminylasparagineIle-Val-LysEplerenone hydroxy acidHydroxycerivastatinArg-LysDeoxyvasicinone2,4-dichlorophenolEnalaprilatImazosulfuronInosine15(r)-17-phenyltrinorprostaglandin f2.alpha.CocaineDL-tyrosine7-hydroxyflavanoneLumichromeTrans-epoxysuccinyl-l-leucylamido(4-guanidino)butaneLamiideTaxol c9s,15s-dihydroxy-5z,13e-prostadienoic acidTyr-Lys-LysRac-5-carboxy-desisopropyltolterodine methyl esterIle-PheCellobioseUreidosuccinic acidLeu-Tyr-ArgD-gluconateO,o-dimethyl dithiophosphate3h-imidazo(4,5-f)quinoline, 2-amino-3-methyl-N.omega.-hydroxy-nor-l-arginine6h-dibenzo[b,d]pyran, 3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-, (6ar,10ar)-4-methyl-1h-pyrazolePaeoniflorinAntipyrine1-methylpiperazineHomovanillic acid sulfateDipyridamole mono-o-.beta.-d-glucuronide17-phenyltrinorprostaglandin f2a methylamideTestosterone decanoateThymopoietin ii (32-34)Arg-Gly-AspFludrocortisoneMepanipyrimTrp-Glu-Arg2-docosahexaenoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine1-myristoyl-sn-glycero-3-phosphocholine16-phenyltetranorprostaglandin e1Hymenamide c1-palmitoyl-2-thiopalmitoyl phosphatidylcholineApigeninGuan-fu base y3-fluorophenmetrazinePglu-glu-pro-amideIsopropylcocaineN-acetylsphingosineIsopropalinAcetylcholine14-benzoylaconineSildenafilIle-Ile-Arg.gamma.-linolenoyl ethanolamideCamptothecinLeu-GlnManoalideAnisatin6,7-dihydroxy-4-methylcoumarinLabetalolDesisopropyldisopyramideL-Histidinol phosphateGlu-Asn-ArgIndole-3-acetamideFlumazenil10-deacetylbaccatin iiiTramadol5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-n-oxide-biotinLactitolCotinineDeoxycorticosterone acetateErucamideAla-Thr5-methoxytryptophan2-chloro-2'-hydroxy-4'-methylbenzophenone5.beta.-pregnane-3.alpha.,17,21-triol-11,20-dioneL-hydroxyarginineDigalacturonic acidN,n-dimethylformamideBufalinTetracyclineMiltefosine9-(2,3-dihydroxy-3-methylbutyl)-4-methoxyfuro[3,2-g]chromen-7-oneN,n'-1,8-octanediylbis[2,2-dichloroacetamide]OxypurinolGly-AspOphiobolin aMethionine sulfoxideMitragynineGly-AsnN-methyl-l-glutamic acid(-)-(3s)-3-hydroxyquinineProstaglandin e2 p-benzamidophenyl esterAzelaic acid2-pentanone, 5-[3-(4-hydroxybenzoyl)-1h-indol-1-yl]-Triphenyl phosphateMevalonic acid 5-pyrophosphateIle-Ala-ArgDiethyltoluamideEpinephrinePhe-pheSalicyluric acidLeu-Asn-ArgVindesineL-canavaninePhosphocreatineAcebutolol(2e,6e,10e)-13-[(2r)-6-hydroxy-2,8-dimethyl-3,4-dihydrochromen-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acidDeacetoxy(7)-7-oxokhivorinic acidAnisomycinDeoxycytidineTris(4-iodophenyl)amineIsatinGlycodeoxycholic acidBiopterin3-phosphoglyceric acidAsiaticosideD-mannitol 1-phosphatefalseMetabolomic Responses to Circadian Rhythm Disruption in Zebrafish<p>Circadian rhythms are essential biological oscillators that synchronize physiological processes, cellular homeostasis, and systemic metabolism with the Earth's natural 24-hour light-dark cycle. While circadian rhythm disruption (CRD) is highly prevalent in modern society due to factors such as shift work, frequent time-zone transitions (jet lag), and artificial illumination, its specific impact on the metabolic landscape during early organismal and brain development remains poorly understood. To investigate the biochemical consequences of circadian misalignment during critical developmental windows, we utilized the zebrafish (Danio rerio) as a diurnal vertebrate model. We established a specific developmental 'jet lag' paradigm by subjecting zebrafish to repeated photoperiod phase shifts across their embryonic and early larval stages. This dataset comprises the raw metabolomic profiling data obtained from these experimental and control samples.</p>2026-06-232026-06-22MTBLS14815