MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14844/m_MTBLS14844_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14844/m_MTBLS14844_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14844/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14844/a_MTBLS14844_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14844/a_MTBLS14844_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14844/s_MTBLS14844.txtprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS14844<p>After normalizing the original peak area information with the total peak area, the follow-up analysis was performed. Principal component analysis and Spearman correlation analysis were used to judge the repeatability of the samples within group and the quality control samples. The identified compounds are searched for classification and pathway information in KEGG, HMDB and lipidmaps databases.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>The LC/MS system for metabolomics analysis is composed of Waters Acquity I-Class PLUS ultra-high performance liquid tandem Waters Xevo G2-XS QTof high resolution mass spectrometer. The column used was a Waters Acquity UPLC HSS T3 column (1.8 μm, 2.1 × 100 mm, Waters, 186003539). Mobile phases for both positive and negative ion modes: A: 0.1% formic acid (TCI, F0654) in LC-MS grade water; B: 0.1% formic acid in LC-MS grade acetonitrile (Merck, 100030).Injection volume 2μL. Waters Xevo G2-XS QTOF high resolution mass spectrometer can collect primary and secondary mass spectrometry data in MSe mode under the control of the acquisition software (MassLynx V4.2, Waters). In each data acquisition cycle, dual-channel data acquisition can be performed on both low collision energy and high collision energy at the same time. The low collision energy is off, the high collision energy range is 10~40V, and the scanning frequency is 0.2 seconds for a mass spectrum. The parameters of the ESI ion source are as follows: Capillary voltage: 2500V (positive ion mode) or -2000V (negative ion mode); cone voltage: 30V; ion source temperature: 100°C; desolvent gas temperature 500°C; backflush gas flow rate: 50L/ h; Desolventizing gas flow rate: 800L/h.</p>Penicillium-Mediated Toxicity and Microbial Dysbiosis Are Associated with Fruiting Body Abortion in Artificially Cultivated Ophiocordyceps sinensis.Peking UniversityDuo KeaisoilWhole Organismmass spectrometry assay<p>For metabolite extraction, 50 mg of each sample was weighed and homogenized with 1000 μL of extraction solvent containing internal standard (20 mg/L) prepared by mixing methanol (Merck, 34860), acetonitrile (Merck, 100030), and LC-MS grade water in a 2:2:1 ratio (v/v/v). The internal standard was L-2-chlorophenylalanine (Aladdin, C105993). The mixture was vortexed for 30 s. Steel beads were then added, and the samples were ground using a grinding mill (45 Hz) for 10 min, followed by ultrasonication in an ice-water bath for 10 min. After incubation at -20°C for 1 h, the samples were centrifuged at 12,000 rpm for 15 min at 4°C. A 500 μL aliquot of the supernatant was carefully transferred to a new Eppendorf tube and dried in a vacuum concentrator. The dried metabolite extract was reconstituted in 160 μL of reconstitution solvent (acetonitrile:water = 1:1, v/v) (Merck, 100030). The mixture was vortexed for 30 s and ultrasonicated in an ice-water bath for 10 min. After centrifugation at 12,000 rpm for 15 min at 4°C, 120 μL of the supernatant was transferred to a 2 mL autosampler vial for LC-MS analysis. A quality control (QC) sample was prepared by pooling 10 μL of each sample.</p>Ophiocordyceps sinensishttps://www.ebi.ac.uk/metabolights/MTBLS14844Shuqi Niu. Chengdu University of Traditional Chinese Medicine. niushuqi@cdutcm.edu.cn.Xiuwen Bao. Chengdu University of Traditional Chinese Medicine. baoxiuwen@stu.cdutcm.edu.cn.<p>The raw data collected using MassLynx V4.2 is processed by Progenesis QI software for peak extraction, peak alignment and other data processing operations, based on the Progenesis QI software online METLIN database and self-built library for identification.</p>Groupkeaiduoduo998@126.com<p>Samples of normal and abnormal fruiting body development of Chinese Cordyceps were collected on the 50th day after the mummification of the host T. xiaojinensis. Larvae samples of the fruiting body of O. sinensis have been formed (CC: the mature stroma stage: fully elongated stipes (length 2-5 cm) with well-differentiated fertile heads) and the fruiting bodies cannot be formed (WZYM: complete absence of primordium on mummified larval cadavers). Soil samples including soil particles naturally attached to the surface of larvae of CC (T-CC) and WZYM (T-WZYM). Specifically, each larval sample was washed with sterile water to remove surface impurities, sterilized with 75% ethanol (Sigma-Aldrich, 459836) for 2-3 min, sterilized with 10-15% hydrogen peroxide (Sigma-Aldrich, 425044) for 3-5 min, and rinsed with sterile water for 5 times. The washing water obtained from the last washing was inoculated onto Tryptone Soybean Agar (TSA) (Solarbio, T8650) and Potato Dextrose Agar (PDA) (Solarbio, P8931) to verify whether the surface sterilization was successful. Fresh samples were frozen at -80 for subsequent analyses.</p>MetabolomicsMetabolomicsACQUITY UPLC I-Class PLUSChinese CordycepsPenicilliumWaters Xevo G2-XS QTofuntargeted analysisOphiocordyceps sinensisfruit bodysoilmicrobiomemetabolomeWhole OrganismMetabolomicsACQUITY UPLC I-Class PLUSChinese CordycepsPenicilliumWaters Xevo G2-XS QTofuntargeted analysisOphiocordyceps sinensisfruit bodysoilmicrobiomemetabolomeWhole Organism<p>The LC/MS system for metabolomics analysis is composed of Waters Acquity I-Class PLUS ultra-high performance liquid tandem Waters Xevo G2-XS QTof high resolution mass spectrometer. The column used was a Waters Acquity UPLC HSS T3 column (1.8 μm, 2.1 × 100 mm, Waters, 186003539). Mobile phases for both positive and negative ion modes: A: 0.1% formic acid (TCI, F0654) in LC-MS grade water; B: 0.1% formic acid in LC-MS grade acetonitrile (Merck, 100030).Injection volume 2μL. Waters Xevo G2-XS QTOF high resolution mass spectrometer can collect primary and secondary mass spectrometry data in MSe mode under the control of the acquisition software (MassLynx V4.2, Waters). In each data acquisition cycle, dual-channel data acquisition can be performed on both low collision energy and high collision energy at the same time. The low collision energy is off, the high collision energy range is 10~40V, and the scanning frequency is 0.2 seconds for a mass spectrum. The parameters of the ESI ion source are as follows: Capillary voltage: 2500V (positive ion mode) or -2000V (negative ion mode); cone voltage: 30V; ion source temperature: 100°C; desolvent gas temperature 500°C; backflush gas flow rate: 50L/ h; Desolventizing gas flow rate: 800L/h.</p>S-AdenosylmethioninaminedGDPL-Leucyl-L- Alanine9,10-DHOMEDL-2-Aminooctanoic acidProstaglandin G2N-alpha-acetyl lysine methyl ester10beta,14beta-Dihydroxytaxa-4(20),11-dien-5alpha-yl acetate2',3'-Cyclic UMP(S)-6-O-MethylnorlaudanosolineArg Ala Leu LysPantothenolLIPC 18:0;3AltretamineL-Histidine1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylateTerpentecinProlyl-Asparagine2-Aminomuconategamma-L-Glutamyl-L-2-aminobutyrateGrayanotoxin I2,3-Dinor-TXB2N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphateCastasteroneQuercetin 3-O-glucosideSlaframine12(13)-EpOME-d4-Amino-5-aminomethyl-2-methylpyrimidineMethylitaconateN8,N'8-Citryl-bis(spermidine)DeacetylcolchicineLupinine13(S)-HpODESer-Ser-OH(2R)-O-Phospho-3-sulfolactateBrassicasterolBADGEDehydrohistidyltryptophyldiketopiperazine8-Demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin Ctris-acetate4,21-DehydrogeissoschizineRoquefortine CPilocarpineDehypoxanthine futalosineGlycyrrhizic AcidUbiquinone 4OxprenololDihydroneopterin phosphateTOFA3',5'-Cyclic GMPAdonixanthin5-Hydroxymethyl-2-furaldehyde3'-Amino-3'-deoxy-AMP4-Hydroxycinnamyl aldehydeHydrogenobyrinate3-[(1R,2S,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoateAbscisic alcohol4-Methylcatechol6-DeoxocastasteroneGlutathioneDeacetylisoipecosideFormyl phosphateCompactinPGA16-Deoxyerythronolide BFMN5-Oxoavermectin ''2b'' aglyconeall-trans-Heptaprenyl diphosphate4-Hydroxy-L-threonine3-VinylcatecholMaltopentaose3-methyl pyruvic acidgamma-L-Glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide3-HexenalNovamethymycinAllopregnanoloneLimonene-1,2-diol2-Hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone12-OxoETE2-Hydroxy-5-methylquinone16-OxopalmitateDioscin3-Oxo-beta-ionone15-Demethylaclacinomycin Tcis-2-Dodecenoic acidPluviatolideValyl-Isoleucinepteroyl-alpha-glutamylglutamateLevetiracetamGlycerol 3-phosphate(3R)-6-Hydroxy-3-isopropenyl-heptanoate1-Oxa-2-oxo-3-hydroxycycloheptaneValyl-Glutamine(S)-Malate3alpha,7alpha-Dihydroxy-5beta-cholestaneErucic acidCDP-DG(16:0/18:2(9Z,12Z))(R)-(+)-Citronellic acidPhosphoribosyl-AMPMetaproterenol2-FluorobenzoateN-cis-octadec-9Z-enoyl-L-Homoserine lactoneall-trans-4-Hydroxyretinoic acid5,10-MethenyltetrahydromethanopterinCanthaxanthin8-Amino-7-oxononanoateCDP-CholineamiclenomycinL-AnserineN-Hydroxy-L-isoleucine21-Hydroxypregnenolone3-Furoic acid3a,7a,12b-Trihydroxy-5b-cholanoic acidHomoveratric acidProstaglandin D1Arginyl-SerineMupirocinCob(II)yrinate a,c diamideGibberellin A44 diacidPERSEITOLAklavinoneMetformin1-Deoxy-11beta-hydroxypentalenateN-AcetylpuromycinDihydrophaseic acid5,10-MethylenetetrahydrofolateFusidic acidMycolactone F5-RibosylparomamineProstaglandin A2Trandolapril4-(beta-D-Glucosyloxy)benzoateAscorbyl stearate6'-Oxo-G418DL-3,4-Dihydroxyphenyl glycolglobomycin5'-[(3-aminopropyl)-amino]-5'-deoxyadenosineTetrahydropteroyltri-L-glutamic acidTylosin(2-Aminobenzoyl)acetate8,8a-DeoxyoleandolideFraxetin13-OxoODEL-Arginine phosphatePapaveroxine8,12-Diethylbacteriochlorophyllide dUric acidDeacetylepithienamycin FAconitic acidLinoleic acidAcitretinNeolinustatin15-keto-Prostaglandin E2Protirelin2,3-Dinor-8-iso prostaglandin F2alphaO-acetylcarnitiniump-CHLOROPHENYLALANINE5-MethylcytosineN-Acetylneuraminate 9-phosphatePhoenicoxanthinGlutathione episulfonium ion2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine10-DeoxymethynolideLys Asp Leu Glu15-keto IloprostRhodovibrin.alpha.-Linolenoyl ethanolamide1-Deoxypentalenate12-Oxo-9(Z)-dodecenoic acidPS(19:0/19:0)1-Stearoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine6'''-Deamino-6'''-hydroxyneomycin CGlycerol 1-myristateLividamine9,12,13-TriHOMEUDP-2,3-bis(3-hydroxytetradecanoyl)glucosamineCephamycin CBestatinCaffeic aldehyde4-methylene DAPPrecorrin 2Psychosinetrans-Cinnamic acid10-DeoxymethymycinAvermectin A1a aglyconeCyanidin 3-O-(acetylglucoside)SalutaridinolAcetyl-DL-ValineS-Adenosyl-L-homocysteinePrecorrin 4PG(16:0/16:1(9Z))PE(19:0/18:1(11Z))Aurachin B epoxideAvermectin A2a monosaccharide6-Carboxy-5,6,7,8-tetrahydropteringamma-L-Glutamyl-L-cysteineRifamycin2-(3'-Methylthio)propylmalic acid4-Hydroxy-3-methoxycinnamaldehydeHydrogenobyrinate a,c diamideSterigmatocystinLysyl-Tryptophan5-Oxopentanoate5-Phenyl-1,3-oxazinane-2,4-dione7,8-Dihydroxykynurenate(8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoateProtoporphyrinogen IX8-hydroxyquinolinePI(16:1(9Z)/0:0)BitocholatePinocarveolMyriocin16-EpivellosimineN3-methylcytosine5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate7-Methylguanine3-Oxo-3-ureidoisobutyrate(R)-pantolactonealpha-(2,6-anhydro-3-deoxy-D-arabino-heptulopyranosid)onate 7-phosphonateHydroxymethylphosphonate22alpha-Hydroxy-campest-4-en-3-one9,10-Epoxy-13-hydroxy-11-octadecenoatedihydrohomopteroate10-Deoxysarpagine2-ThiocytidineL-2-Aminoadipate 6-semialdehyde6-endo-Hydroxycineole6'''-Deamino-6'''-hydroxyparomomycin IIGlutathione disulfidePI(10:0/16:1(9Z))UDP-N-acetyl-alpha-D-glucosamineZolmitriptanPikromycinIsoleucyl-Glutamate(7Z,10Z,13Z)-Docosatrienoyl-CoAp-Salicylic acidN4-AcetylaminobutanalNadololPA(14:1(9Z)/16:0)Precorrin 3AZingerone14-DemethyllanosterolChenodeoxycholateGlycocholateN6-(Delta2-Isopentenyl)-adenineNopalineTXB3PI(14:0/16:1(9Z))TXB110-OPDAPS(18:1(9Z)/0:0)Mirtazapine5-Aminopentanoate100-13D-3,5/4-Trihydroxycyclohexane-1,2-dione4-HYDROXY-6-METHYLPYRAN-2-ONE8-Demethylnovobiocic acid9-Oxononanoic acidbeta-Alanyl-L-arginineNeurosporaxanthinC-2 CeramideDiscadenine11-dehydro TXB2pyrithiamine phosphateDG(14:1(9Z)/16:1(9Z)/0:0)Carnitine(5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acidL-Glutamate15-Demethoxy-epsilon-rhodomycin11a-HydroxytetracyclineAbscisic acid glucose esterEcgonine methyl ester4-HexanolideDihydroclavaminic acidN-[(2S)-2-Amino-2-carboxyethyl]-L-glutamateCyanidin1-Stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine5-MethoxyindoleacetatePS(16_0_16_0)3'-O-methyladenosineDihydrogranaticin7-Methyluric acidL-azaserineUDP-D-galactose4'-DeoxyuridineL-AdrenalinePE(18:0/18:1(9Z))ProtoanemoninIso-OlomoucineSecologanate5,6,7,8-Tetrahydromethanopterin(¡À)9-HODE1-Oleoyl-rac-glycerolPhosphatidylserine17-O-Acetylajmaline4-Androsten-17.beta.-ol-3-one glucosiduronateLolitrem EProstaglandin J2S-(5'-Adenosyl)-L-methionine p-toluenesulfonate saltLolitrem B5'-(aminoiminomethyl)amino-5'-deoxyadenosine dihydrogen sulfateArginyl-HistidineBiocytinIndoxylSoraphen AN1-Hydroxy-roquefortine CDL-Leucinecoumarin-SAHAPE(14:0/0:0)1-MethyladenosineGln-KPALeucyl-AsparagineCalcidiolUDP-3-O-(3-hydroxymyristoyl)-N-acetylglucosamine4,5-dehydro Docosahexaenoic Acid4-(beta-D-Ribofuranosyl)phenol 5'-phosphateDihydrophloroglucinol7'-O-DmethylcephaelinePyrimidodiazepineStrigolLeukotriene F4Landomycin E1-(3,4-Dihydroxyphenyl)-5-hydroxy-3-decanoneAvermectin A1b aglycone9alpha-Hydroxyandrosta-1,4-diene-3,17-dioneSafranal2,6-Dihydroxypseudooxynicotine2-Methyl-3-oxopropanoate2-Hydroxy-2H-benzo[h]chromene-2-carboxylateGlycosyl-4,4'-diaponeurosporenoateVerruculogenLeukotriene E43beta-Hydroxy-9beta-pimara-7,15-diene-19,6beta-olideAuramycinone17alpha-HydroxypregnenoloneAbu-Asn-OH(25R)-3-Oxocholest-4-en-26-oatePE(18_1(9Z)_0_0)PYRITHYLDIONEIsochorismate7-Methylguanosine6-Hydroxy-3-succinoylpyridine6-O-Methyl-N-deacetylisoipecoside aglyconDesacetoxyvindolineLysyl-Lysine(3Z)-PhycoerythrobilinTroglitazoneThiamin monophosphate20,21-Diprenylterpendole IPI(22:0/0:0)Tetrahydropalmatine5-Amino-4-imidazolecarboxyamideIPC 18:0;3/18:0;13',5'-Cyclic diGMP20,21-Diprenylterpendole CMETHYL-4-HYDROXYBENZOATEalpha-methylmethionineNordihydroguaiaretic AcidLeukotriene C4L-TryptophanTriethanolamine3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oateGlutamyl-CysteineAmygdalin4-TrimethylammoniobutanoateUDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronateWithaferin AN-amino DAPLipid XN-3-Hydroxyoctanoyl-L-homoserine lactone9(S)-HOTrEgamma-Tocopherol3alpha,11beta,21-Trihydroxy-5beta-pregnan-20-onedCMPGlycitinGlutamyl-HistidineNeomycin BNeomycin Cxi-3-(4-Isopropylphenyl)-2-methylpropanalPantothenateCarlactoneDecenoylcarnitine[6]-Gingerol3',4'-AnhydrovinblastineCDP-DG(18:1(9Z)/18:2(9Z,12Z))NarcotolineLysyl-ValinecoformycinUndecaprenyl phosphate alpha-L-Ara4FN(3R,2'S)-Myxol 2'-alpha-L-fucosidePI(18:1(9Z)/0:0)N-(3-Oxooctanoyl)homoserine lactone2-IsopropylmaleateFungichrominMorphine6.alpha.-MethylprednisoloneCreatineS(8)-aminomethyldihydrolipoamideMinoxidil4,4'-DiapolycopeneSphingosine 1-phosphateIsoniazid alpha-ketoglutaric acidTetradecenoylcarnitinemaltoheptaose3'-DemethylstaurosporineBeauvericinDehydroascorbate2-[(2-Aminoethylcarbamoyl)methyl]-2-hydroxybutanedioateCDP-4-dehydro-3,6-dideoxy-D-glucosePentanoic acidCyclopropanecarboxylateDipyridamoleDIHYDRO-¦Â-TUBAIC ACIDDihydro-O-methylsterigmatocystinErythromycinCyanuric acid22-Hydroxydocosanoate9(S)-HODE3-Hexaprenyl-4,5-dihydroxybenzoateMethymycin(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoateBrassinolideSolavetivone2,3-Dihydro-2,5-dihydoxy-6-methyl-4-H-pyran-4-one2-Hydroxycyclohexan-1-oneProlyl-TryptophanGentamicin C1NADPHpyrimidin-2-one-ribonucleosideDesoxypeganine5-HydroxyisouratePseudooxynicotineL-Ala-gamma-D-Glu-Dap1,6-DimethoxypyreneDigoxigenin9(10)-EpOMEFolategamma-Oxalocrotonate3-[(1E,4R)-4-Hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate12(S),20-DiHETEApigenin 7-glucosidePG(16:0/16:0)Homocarnosine3-Hydroxy-palmitic acid methyl esterDeoxycoformycinNicotinic acid mononucleotidePC(20:4(8Z,11Z,14Z,17Z)/18:2(9Z,12Z))OlmesartanSalanninMethylgingerolCrepenynatePelargonidin 3-O-glucosideMEDICA 163-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dionedimethylsuberimidateCDP-DG(18:0/22:3(10Z,13Z,16Z))Ginsenoside Rb1Omeprazole5-epi-Valiolol 7-phosphatePC(10:0/16:0)PE(18:0/0:0)PC(18:1(11Z)/18:3(9Z,12Z,15Z))UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose5-Hydroxyferulic acid methyl ester13,14-dihydro-19(R)-hydroxyPGE1N-OleoylglycineGentamicin C26,8a-Seco-6,8a-deoxy-5-oxoavermectin ''2a'' aglyconeTerpendole EKaempferol 3-O-rutinosideN-Acetyl-L-phenylalanine5-Hydroxyconiferyl alcoholTerpendole ICDP-DG(18:0/18:0)16-FeruloyloxypalmitateTerpendole JPteridineChitobioseBacampicillinsn-Glycerol 3-phosphateTetrahydrobiopterinAvermectin A2bAuraviketoneAcetoxy-6-gingerol(6Z,9Z,12Z)-Octadecatrienoic acidValyl-AsparagineHistidinyl-TyrosineAminoparathionSerinyl-Arginine5-Methyl-5,6,7,8-tetrahydromethanopterin1-(3,4-Dihydroxyphenyl)-1-decene-3,5-dione(9Z)-Hexadecenoic acid4-Deoxy-4-thio-alpha-D-digitoxosyl-calicheamicin T0Vitisin BDeoxyadenosineTrypanothioneN-acetyl-D-prolineDecanoyl-L-carnitine(R)-5,6-DihydrothymineAsp-Phe methyl esterLys Gln Asp LysGlycerophosphocholinePhenethyl CaffeiateNONIC ACIDIsonicotinoyl radicalUrdamycinone F2,3-Dinor-8-iso prostaglandin F1alpha(E)-2-Butenyl-4-methyl-threonineUrdamycinone BdcSAM10,16-Dihydroxyhexadecanoic acidApiin4-DemethylpremithramycinoneN-Methylglutamic acid5'-BenzoylphosphoadenosineDiethylcarbamazine1-ethyl-3-(3-dimethylaminopropyl)-carbodiimideAclacinomycin TGlaucarubinGibberellin A14 aldehyde4-Imidazolone-5-propanoate(S)-ReticulineAclacinomycin YPyropheophorbide aSalbostatin5-Methoxysalicylic acidEchitoveninealpha-D-glucose 1-methylene-phosphonate7-Mercaptoheptanoic acidMaslinic AcidIsoleucyl-LysineL-Pyrrolysine2-Methylquinolin-4-olPrekinamycin6alpha-Hydroxy-castasterone4-methylumbelliferone3-O-Mycarosylerythronolide B2-MethyleneglutaratedTDP-alpha-D-fucofuranoseU-46619 Glycine methyl esterN-Acetyl-D-muramoateN-Acetylmuramate1D-1-Guanidino-1-deoxy-3-dehydro-scyllo-inositolMethionyl-Leucine2-(Hydroxymethyl)-4-oxobutanoateOleyl alcoholUWM6Tyrosyl-ArginineC20913N-CarbamoylsarcosineC209111-Oleoyl Lysophosphatidic Acid17-phenoxy trinor Prostaglandin F2¦ÁMalvidin 3-O-(cafeoylglucoside)Maleic acid(S)-Chiral alcohol2-Ethyl-4-hydroxy-5-methyl-3(2H)-furanoneFlavin adenine dinucleotide (FAD)3-PropylmalateEicosanoyl-CoA3A-Deolivosylpremithramycin BdTDP-2,6-dideoxy-D-kanosamineLysyl-ProlineGluconic acidCDP-DG(16:0/20:4(8Z,11Z,14Z,17Z))GlutathionylspermineN-Acetyl-D-lactosamine3-Hydroxyoctadecanoyl-CoA22alpha-Hydroxy-campesterol10-Hydroxycarbazepinebeta-D-Glucosyl crocetinUndecanedioic acidCorydalineGeranylhydroquinoneVersiconol acetateN-EthylammelideLolitriolAPGPR Enterostatin17-phenyl trinor PGF2¦ÁPyridoxamine dihydrochlorideIsoleucyl-Methionine(2R,3R)-3-Methylornithinyl-N6-lysinediethyl tartrate2-Amino-5-oxocyclohex-1-enecarbonyl-CoANarbomycinThromboxane B24-Hydroxy-L-glutamic acidErgotamineMifepristoneColnelenic acidCDP-DG(18:1(11Z)/16:0)L-2-Aminoadipic acid3beta-Hydroxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-4alpha-carboxylatePantoprazoleArginyl-Lysine2-Chloro-3-oxoadipate1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene13-Desoxypaxilline2-Hydroxy-3-(4-hydroxyphenyl)propenoateGlycolaldehydeRutin3,4,5-Trimethoxycinnamic acidThreoninyl-GlutamatePyridoxal phosphateIrinotecanbeta-D-Gentiobiosyl crocetinLysoPE(20_3(8Z,11Z,14Z)_0_0)MandelonitrileSulfathiazoleHydrocortisone succinateL-(-)-3-Phenyllactic acid18alpha.-Glycyrrhetinic acidAdenosyl cobyrinate hexaamideAminohippuric acidGlucosan3-Oxopalmitoyl-CoARiboflavinRamiprilL-PipecolateAspartame9-deoxy-9-methylene-16,16-dimethyl -PGE29-Hydroxy-12-oxo-15(Z)-octadecenoic acidAvermectin A1a monosaccharide(6S)-HydroxyhyoscyamineCaffeic Acident-11beta-Hydroxycassa-12,15-dienePotassium sorbateergosteryl 3-beta-D-glucosideN-Hydroxyl-tryptamineCMP-2-aminoethylphosphonateDehydroergosterolPhytyl diphosphatePE(18:1(11Z)/14:0)(R)-(Homo)3-citrateL-ProlinePaxillineIle Thr Tyr AspSer Leu Val GluValyl-Valinebeta-PC-M6Syringic acid2-MethylbutyroylcarnitineVal Ile Leu AspPC(18:3(9Z,12Z,15Z)/P-18:1(11Z))L-FucitolCyclohexane-1-carboxylate(S)-3-Methyl-2-oxopentanoic acid2-Aminovalienone2-Acetamido-4-(D-alanylamino)-2,4,6-trideoxy-D-mannopyranose3-alpha,11-beta,17,21-tetrahydroxy-5-beta-pregnan-20-oneKanamycin BArginyl-ThreonineValienone 7-phosphate5-Acetamidopentanoate3-beta-D-Galactosyl-sn-glycerolPantothenic Acid1,5-Dodecanolidebeta-NitropropanoateDihydrochelirubine2-Methoxyestrone3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylic acidSclareol9,10,13-TriHOMEethyl-9-decenoateEstriolL-Olivosyl-oleandolideGlutaryl-L-carnitineTrihomomethioninecis-4-Carboxymethylenebut-2-en-4-olide2'-N-Acetylparomamine9(S)-HpOTrECDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol3alpha-Hydroxy-3,5-dihydromonacolin L acidIsoproturonGlycyl-AspartateTeasteronecis-1,2-Dihydrobenzene-1,2-diolUridine diphosphate-N-acetylglucosaminePseudouridine1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate(S)-3-Hydroxybutanoyl-CoAN1-(3,4-Dihydroxybenzoyl)-N8,N'8-citryl-bis(spermidine)1-Palmitoyl Lysophosphatidic AcidValidamine 7-phosphateL-Formylkynurenine2-Amino-2-deoxyisochorismatetrans-Crocetin (beta-D-glucosyl) (beta-D-gentibiosyl) ester13-epi-12-oxo Phytodienoic AcidTiglylcarnitineAlanyl-GlutamatePI(14:0/16:0)Portulacaxanthin IIButorphanol4-Pyridoxic acid1H-Indole-3-propanoic acidPC(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))PE(16:1(9Z)/16:1(9Z))ALANYL-dl-LEUCINE(3S,5S)-3,5-Diaminohexanoate9-[6(RS)-8-diamino-5,6,7,8-tetradeoxy-beta-D-ribo-octofuranosyl]-9H-purin-6-amine7-Keto-8-aminopelargonic acid1-(2-Aminophenyl)decane-1,3-dioneMoxifloxacinL-HistidinalDoxorubicinPseudouridine 5'-phosphateCytochalasin B2-n-heptyl-4-hydroxyquinoline-N-oxide17alpha-Hydroxyprogesterone3-Methylxanthine19-HydroxytestosteroneCoenzyme F420-0N-Methyl-cyclo(L-Trp-L-Phe)5-OxoprolineHexadecanedioic acid6-Hydroxyhexan-6-olideLoganinMidodrineFMLPPregnanolone3-MethyladenosineEstriol 16.alpha.-(.beta.-D-glucuronide)Nicotinurate2-epi-5-epi-Valiolone3-Carboxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-propanoic acidL-Thyroninedelta-(L-2-Aminoadipyl)-L-cysteinyl-D-valineAsparaginyl-AsparaginePyrophosphate(R)-(Indol-3-yl)lactate4-HydroxyphenylacetaldehydeFumigaclavine CPhenanthrene-1,2-oxidePhosphoribosyl formamidocarboxamideDulcitol2'-Deoxy-5-hydroxymethylcytidine-5'-triphosphateValyl-Proline1-Formyl-2-indanonePhytosphingosine 1-phosphateN1-Amidinostreptamine 6-phosphate3-Methylpyrrole-2,4-dicarboxylic acid3,5-tetradecadienoateNostoxanthinPalmatineTryptophyl-TryptophanEmetineHomovanillyl alcohol3-pyridinecarboxaldehyde adenine dinucleotideLeucyl-GlutamateNogalonate3-Hydroxy-7,8-dihydro-beta-ionolCyanidin 3-O-(coumaroylglucoside)4-(beta-Acetylaminoethyl)imidazoleN1-Acetyl-tabtoxinine-beta-lactamSuberylglycineS-Ribosyl-L-homocysteinePeonidinGlycochenodeoxycholateDodecanoylcarnitinePhenylalanyl-Valine2-Heptyl-3-hydroxy-quinoloneTetrahomomethionineN-Acetyl-D-phenylalanineAvermectin B2a aglyconeCycloheximide2'-Deoxyinosine 5'-phosphateAflatoxin B23-Iodo-L-tyrosineGW 7647CDP-DG(18:0/20:4(8Z,11Z,14Z,17Z))Histidinyl-Tryptophan(S)-5-Oxo-2,5-dihydrofuran-2-acetateL-RhamnosecephalexinSucrosePI(16:0/0:0)Ginsenoside Rc8-hydroxy Guanosine3,4-Dihydroxy-L-phenylalanine(13S,14R)-1,8-Dihydroxy-13-O-acetyl-N-methylcanadineAntibiotic G-418PC(o-16:0/20:4(8Z,11Z,14Z,17Z))Biotin sulfoxideDL-2-Aminoadipic acidPA(14:0/16:1(9Z))18-Hydroxyoleate6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglyconeD-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate10-Deacetyl-2-debenzoylbaccatin IIIHexadecanalPentalenolactone3-{[(2E)-4-Amino-4-oxobut-2-enoyl]amino}-L-alanineL-CanavanineN-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphateHomoisocitrate(1R,6R)-1,4,5,5a,6,9-Hexahydrophenazine-1,6-dicarboxylateAcetyl-DL-LeucineTrichostatin APA(18:0/16:1(9Z))LysoPE(18_0_0_0)Cephaeline2,5-DioxopentanoateFolinic acid3,6,8-TrimethylallantoinMycolactone2-Isopropylmalic acidR-THMFIPC 18:0;3/24:0;2Emindole SBNorfloxacin7-Oxoheptanoic acidAmmelineUDP-2-acetamido-4-(D-alanylamino)-2,4,6-trideoxy-alpha-D-glucose3'-N-DebenzoyltaxolN,N'-DiacetylchitobioseC1'-C9-Glycosylated UWM6N-Carboxyethyl-¦Ã-aminobutyric acidDesacetylvindolinePerindoprilAnhydrorhodovibrinPC(16:1(9Z)/0:0)MetanephrinePaspalicine2-hydroxyhexadecanoic acid2,3-Bis(4-hydroxyphenyl)-1,2-propanediolOxaprozinN-Monomethyl-2-aminoethylphosphonateHexahomomethionine2-keto valeric acid7,8-Dihydroneopterin 2',3'-cyclic phosphateN-Acetylmuramic acid 6-phosphateN,N'-DiformyldityrosinePrunasin{[(2S,3S,4R)-2-amino-3,4-dihydroxyicosyl]oxy}phosphonic acidLinalool oxideOleandrinIsocorypalmineCreatinine3-Dimethylallyl-4-hydroxymandelic acidIsoleucyl-AsparagineE-64zymosterol intermediate 1a3-ketosphingosine(2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinateD-Xylonate9-(Dimethylallyl)-5,10-dihydrophenazine-1-carboxylate2-epi-5-epi-Valiolone 7-phosphate3-Oxo-OPC6-CoA5-Methylthio-D-riboseGDP-4-amino-4,6-dideoxy-alpha-D-mannoseAcetone1,2-DehydroreticulineDihydrobiopterinDictamnineLPA(16:0/0:0)Gibberellin A53 aldehyde11(R)-HEDE2-Hydroxy-6-oxoocta-2,4,7-trienoateAstaxanthinCortisol3-(2-Hydroxyphenyl)propanoate7a-Hydroxy-O-carbamoyl-deacetylcephalosporin CUrobilin5-FluorouridinePS(19:0/16:1(9Z))5-O-beta-D-MycaminosyltylonolideArginyl-IsoleucineN-Acetyl-O-demethylpuromycin-5'-phosphateMaltose 6'-phosphatePhenylalanyl-IsoleucineCDP-ethanolamineHesperetinGinsenoside Rh2RetinoateO-MethylandrocymbineCalicheamicinone4,6-Dioxoheptanoic acidLobelineMyristoyl-coenzyme AAbacavir(E)-4-Hydroxyphenylacetaldehyde oximeDemethyllactenocinProcaterolCanavanineProdigiosinMETHYLTHIOURACIL(9Z,12Z,15Z)-Octadecatrienoic acid3-Methylmuconolactone5''-PhosphoribosylparomamineHydrocortisoneDodecanoic acidIsoleucyl-Threonine2¡ä-Deoxycytidine 5¡ä-monophosphateStealthin CPyridostigmine cation3-beta-Hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylateN-Demethyl-desepoxymaytansinol4-Amino-4-deoxychorismateEthylvanillatesinefunginGlycyl-LysinePC(18:3(6Z,9Z,12Z)/P-16:0)tadalafilKAPATraumatic AcidDocosatetraenoyl EthanolamideDeacetylvindolineValyl-Tryptophan12(13)-EpOME11a-Hydroxyoxytetracycline13(S)-HODE6'-Oxogentamicin X2Erythromycin BAvermectin A2b monosaccharideErythromycin CQuinateAPCNeomethymycinValienonePremithramycin A3PE(16:1(9Z)/0:0)Tryptophyl-Glutamate4-Methylene-L-glutamate3-Acetyl-11-keto-.beta.-boswellic acidTaxa-4(20),11(12)-dien-5alpha,13alpha-diolHydroxyspheroidenoneSulfateNeoxanthinEthisteronePS(19:0/16:0)XanthohumolDigoxinL-AnticapsinDemethyl-desacetyl-rifamycin S8-Demethyl-8-(methylamino)riboflavinSer-Abu-OH20-OH-Leukotriene B415-Deoxy-Delta12,14-PGJ2Arginyl-Aspartatetrans,trans-Farnesyl phosphateL-Homoserine1,11-Undecanedicarboxylic acidFeruloylagmatine4'-Oxonebramine2-Deoxy-scyllo-inosamine12alpha,13alpha-Dihydroxyfumitremorgin CAtropineGlutathionylspermidineAcetosyringoneTaxifolin1-(4-Hydroxyphenyl)-1-decene-3,5-dione4beta-methylzymosterol-4alpha-carboxylic acidAjmalineNystatin5-Hydroxy-1-(4-hydroxyphenyl)-3-decanoneRifamycin SN-Cyclopropylammeline1-Aminocyclohexanecarboxylic acidDapdiamide AL-Ala-gamma-D-Glu-DAP-D-AlaSpiramycin 1L-Gulonic ¦Ã-lactoneL-UrobilinCobinamide6-OxocampestanolN-lactoyl-phenylalanineChlorogenateDapdiamide CLysyl-AspartatePentamidineGibberellin A1413S-HpOTrE(gamma)2-OxosuberateRifamycin B2-Oxoindole-3-acetate¦Ä-CEHC2'-DeoxycytidineKaempferol-3-O-rutinoside19-Hydroxyandrost-4-ene-3,17-dioneGlycerophospho-N-Palmitoyl EthanolamineCalycosinDopaquinonePC(18:3(9Z,12Z,15Z)/20:2(11Z,14Z))fructoselysine-6-phosphatePE(14:0/16:1(9Z))Clasto-Lactacystin ¦Â-lactoneL-HistidinolCMP-N-glycoloylneuraminatePodophyllotoxinSirolimusRicinoleic acidCoproporphyrinogen III(S)-Autumnaline5-Oxoavermectin ''1a'' aglyconePE(12:0/16:1(9Z))Histidinyl-MethionineD-GlutamineFluoren-9-olLeucodelphinidinXanthoxic acidIle Gln Asn Glu3-(O-Geranylgeranyl)-sn-glycerol 1-phosphateRifamycin W2-Hydroxy-cis-hex-2,4-dienoatePsilocinMethyl beta-D-galactoside11beta-17alpha-21-Trihydroxy-5alpha-pregnane-3,20-dioneXylobioseSerotoninDihydro-4,4-dimethyl-2,3-furandioneIndoxyl ¦Â-D-glucoside20-hydroxy LTB4Thienamycinprecorrin-12,4-Dihydroxy-6-pentylbenzoate17-Ketostypolhydroperoxide(4aR,10bS)-NormaritidineN1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazolecis-3,4-Leucopelargonidin1-ethyladeninePinacidilBudesonide1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholineIndolelactic aciddUTPtaurocholic acidRhodopinal glucoside(S)-N-MethylcanadinefumagillinCannabidiolic acidcis-9,10-Epoxystearic acidAdrenic AcidNarbonolide21,22-DiprenylpaxillineGramicidin S16-phenoxy tetranor Prostaglandin A2Tryprostatin AIle Gln Lys GluAbscisateNovapikromycinAsparaginyl-Phenylalanine1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate7-O-Acetylsalutaridinolponasterone AArachidonoyl SerinolButenoyl PAFFumitremorgin AShikimate 3-phosphateDihydrozeatin-O-glucoside2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-oneCoumarinDihydrojasmonic AcidGibberellin A53Arachidonoylmorpholine2,3-Bis-O-(geranylgeranyl)-sn-glycero-1-phospho-L-serineGlutamyl-GlutamineSepiapterinPI(12:0/14:0)Succinic acid7,8-DihydromethanopterinN6-methyladenosinePhenyllactic acid17-O-Acetylnorajmaline12-Demethyl-11,12-dehydropaspalineLinamarin3,4-DihydrospheroideneMegalomicin C1Estradiol valerateNPCColforsin3-Aminosalicylic acidPE(16:1(9Z)/19:0)5a,11a-DehydrooxytetracyclineGibberellin A24Copal-8-ol diphosphateRhizocticin AL-Ala-L-GluGibberellin A20Ascorbic acid 6-palmitateCytarabine(1S,4R)-1-Hydroxy-2-oxolimonene3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoateStizolobinatePrecorrin 8XOxaloglutarate2-Propylmalate(S)-N-MethylcoclaurineNateglinideLysoPC(18:2(9Z,12Z))AflatremN6-(delta2-Isopentenyl)-adenosine 5'-monophosphateDelta(6)-trans,Delta(8)-cis-leukotriene B4Baccatin IIIArginyl-Methionine8-[(1R,2R)-3-Oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoateS-(Hydroxymethyl)glutathionetrans-Zeatin riboside monophosphateAdenineTyr Gln Thr LysGibberellin A365-Sulfosalicylate3-methoxy-4-hydroxyphenylalanine monohydrate1-Oleoyl-sn-glycero-3-phosphocholinePhe Ile Gln Lysindolmycin4-Hydroxy-3-methylbenzaldehydeoctyl alpha-D-glucopyranosideDodecenoylcarnitine6alpha-Hydroxycampestanol(4-{4-[2-(gamma-L-Glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamineL-Serine3-Nitro-L-tyrosine17-Octadecynoic AcidD-Lactic acidhydroxyl diethyl succinate2'-Hydroxydihydrodaidzeincis-2,3-Dihydroxy-2,3-dihydro-p-cumate9R,10S-EpOMEPI(14:0/0:0)PG(16:1(9Z)/16:1(9Z))Leu Ile Ser GluSinapyl aldehyde2'-O-methyladenosine9,10-DihydroxystearateCholic acid1,3,5(10)-Estratrien-3,17.beta.-diol 17-glucosiduronateD-CathinoneLividomycin Blevallorphan(3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA2-deoxygluconateConiferyl aldehydeAbscisic aldehydeAlanyl-TyrosineTyr Val Lys LysPS(14:1(9Z)/16:0)Methionyl-TyrosineAvermectin B2b monosaccharideborrelidinQueuineErythronolide BNonanoic acidCucurbitacin BAconitineSebacic acid(¡À)12(13)-EpOMEepsilon-CaptrolactoneD-Ribitol 5-phosphateThiamin triphosphatePGF1a1,1,6-Trimethyl-1,2-dihydronaphthaleneGlycyrrhyzin3-DehydroquinateSphinganine 1-phosphate3-Methyl-2-oxobutanoic acid(3S)-Citryl-CoAThalianolactinoninMedermycinL-4-Hydroxyglutamate semialdehydeCathenamineCoutaric acidDihydrozeatin ribosideAvicholateMyricetin 3-O-glucuronideOzagrelN-AcetylornithineAklaviketonePenitrem DD-GlucarateIsoniazid pyruvatePrephenateMannitolDL-2-hydroxy stearic acidGlucose 1-phosphateDodecanedioic acidAurachin B3-Dimethylallyl-4-hydroxybenzoate5-HydroxyferulateHistidinyl-HistidinePE(17:0/17:0)5-Fluorouridine diphosphate¦Ã-Glu-Cys3-alpha(S)-Strictosidine9-[6(RS)-C-carboxamido-5,6,7-trideoxy-beta-D-ribo-octofuranosyl]-9H-purin-6-amineDeoxyguanosine1-MethylnaphthaleneGentamicin X22-Hydroxy-6-ketononatrienedioatetrans-EKODE-(E)-IbAurachin DAurachin CVisnadin.gamma.-L-Glu-.epsilon.-L-LysLysoPC(20:4(8Z,11Z,14Z,17Z))PA(20:4(5Z,8Z,11Z,14Z)e/2:0)(S)-2,3,4,5-Tetrahydropyridine-2-carboxylateProglumideLysyl-MethionineThymidineN6-Hydroxy-L-lysine6-Keto-prostaglandin F1alphaPantetheineD-Alanine7-MethylxanthosineOleandomycinHydroxychlorobactene glucosideMalic acidp-Acetamidophenol (Acetaminophen, Tylenol)D-OctopineAvermectin B2b aglyconeDocosanedioatepiericidin AdIDP7,8-Didemethyl-8-hydroxy-5-deazariboflavinNodularinTetradecanoyl-CoA(S)-6-HydroxynicotineN(gamma)-AcetyldiaminobutyrateSimvastatinL-Aspartic AcidSerinyl-Phenylalanine(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene2,2'-(3-methylcyclohexane-1,1-diyl)diacetic acidTetracycline2,3-Dinor-11b-PGF2aAdipate semialdehydeProstaglandin D1 Alcohol¦Á-CEHCIsocitrateTraumatinStrigolactone ABC-ringsAvermectin B1a3,6-Nonadienal7-Deoxyloganetic alcoholMonacolin J acidL-Fucono-1,5-lactone(7S,8S)-DiHODETegafurPS(18:1(11Z)/19:0)Ile Val Leu GluCrocinUDP-6-sulfoquinovose19-Chloroproansamitocin2,5-Diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinoneSenecionineUrea-1,3-dicarboxylateAzelaic acidDexverapamilAvermectin B2acis-2-Carboxycyclohexyl-acetic acidPomiferinL-hydroxy ArginineN-hydroxy DAPN-Demethyl-desepoxyansamitocin P-32,5-FurandicarboxylateIle-Ala-Arg2-Amino-5-oxohexanoatePC(16:1(9Z)/20:3(5Z,8Z,11Z))PS(17:0/19:0)Nicotinamide D-ribonucleotide(9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid5-Hydroxyindoleacetate4a-HydroxytetrahydrobiopterinPS(18:0/0:0)N1-AcetylspermineN-Methyl-L-glutamate3b-Hydroxy-5-cholenoic acid(Z)-3-Hexen-1-ol acetateN(pi)-Methyl-L-histidine2'-DeoxyguanosineAcetic acid, phenyl esterDeoxycytidinePC(18:2(9Z,12Z)/24:0)Indolylmethyl-desulfoglucosinolateCer 18:0;3/18:0;1AdynerinHexadecanedioateDaidzeinCaloxanthin(11Z,14Z)-Icosadienoyl-CoAfalsePenicillium-Mediated Toxicity and Microbial Dysbiosis Are Associated with Fruiting Body Abortion in Artificially Cultivated Ophiocordyceps sinensis<p>The Chinese caterpillar fungus, Ophiocordyceps sinensis, is a valuable medicinal entomopathogenic fungus, but artificial cultivation is hindered by fruiting body abortion, severely impacting yield and quality. The interactions between the fungus, its host insects, and soil are critical for its development. Multi-omics analyses were conducted to compare normally and abnormally developing samples, examining microbial communities and metabolites in endophytic larvae and the surrounding mycosphere soil. Abnormal stroma development significantly altered microbial ecology. It increased fungal diversity in both larvae and soil, while reducing bacterial diversity within larvae. The microbial composition shifted markedly, characterized by a high enrichment of Penicillium fungi and a depletion of Bacillus bacteria in and around abnormal samples. Cross-kingdom microbial network analysis in these samples showed fewer connections and lower stability. Metabolomic profiling revealed significant enrichment of the antibiotics N1-hydroxy-roquefortine C and glandicoline A, both derivatives of roquefortine C, alongside the enrichment of multiple antibiotic biosynthesis pathways. Partial Least Squares Structural Equation Modelling indicated that Penicillium toxicity likely induces microbial dysbiosis, and this disruption of microbial homeostasis is the primary cause of fruiting body abortion. The findings suggest that Penicillium overgrowth is detrimental to normal stroma formation. Conversely, Bacillus may play a crucial role in suppressing Penicillium, offering a potential target for biocontrol strategies. This study is the first to elucidate the key role of Penicillium-mediated toxicity and microbial imbalance in the developmental disorders of Chinese Cordyceps.</p>2026-06-242026-06-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