which was developed using R and based on XCMS, for feature
detection, extraction, alignment, and integration. The R package and the BiotreeDB(V3.0)
were applied in metabolite identification.
Reference: Zhou, Z., Luo, M., Zhang, H., Yin, Y., Cai, Y., & Zhu, Z. J. (2022). Metabolite
annotation from knowns to unknowns through knowledge-guided multi-layer metabolic
networking. Nature communications, 13(1), 6656
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - positive - hilic","Liquid Chromatography MS - negative - hilic"],"chromatography_protocol":["For polar metabolites, LC-MS/MS analyses were performed using an UHPLC system
(Vanquish, Thermo Fisher Scientific) with a Waters ACQUITY UPLC BEH Amide (2.1 mm × 50
mm, 1.7 μm) coupled to Orbitrap Exploris 120 mass spectrometer (Orbitrap MS, Thermo). The mobile phase consisted of (A) water containing 25 mmol/L ammonium acetate and 25 mmol/L ammonium hydroxide (pH 9.75) and (B) acetonitrile.
"],"publication":["Spirulina Prevents Hepatic Steatosis by Promoting Macrophage M2 Polarization via Gut Microbiota-Derived 2-Hydroxy-3-Methylbutyrate."],"submitter_affiliation":["Hainan medical university"],"submitter_name":["Daya Zhang"],"organism_part":["faeces"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Then the mixed samples were homogenized (35 Hz,4 min) and sonicated for 5 min in 4 ℃
water bath, the step repeat for three times.
The samples were incubated for 1 h at -40 ℃ to precipitate proteins. Then the samples
ware centrifuged at 12000 rpm (RCF=13800(×g), R= 8.6cm) for 15 min at 4 ℃. The
supernatant was transferred to a fresh glass vial for analysis.
"],"organism":["Mus musculus"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS14903"],"author":["Daya Zhang. Hainan medical university. Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University； No.368 Yahai Road, Longhua District, Haikou City, Hainan Province, China， 570216. 875025464@qq.com."],"data_transformation_protocol":["The raw data were converted to the mzXML format using ProteoWizard and processed
with an in-house program.
"],"study_factor":["Group"],"submitter_email":["875025464@qq.com"],"sample_collection_protocol":["The animal tissue samples (25 mg±1 mg) were taken, mixed with beads and 500 μL of
extraction solution (MeOH:ACN:H2O, 2:2:1 (v/v)). The extraction solution contain deuterated
internal standards. The mixed solution were vortexed for 30 s.
"],"omics_type":["Metabolomics"],"study_design":["Thermo Scientific Vanquish UHPLC System","ProteoWizard msconvert","pooled quality control sample","Metabolomics","Mus musculus","faeces","Hepatic Steatosis","untargeted analysis","Thermo Scientific Orbitrap Exploris 120","2-hydroxy-3-methylbutyrate","untargeted metabolite profiling","experimental sample"],"curator_keywords":["Thermo Scientific Vanquish UHPLC System","ProteoWizard msconvert","pooled quality control sample","Metabolomics","Mus musculus","faeces","Hepatic Steatosis","untargeted analysis","Thermo Scientific Orbitrap Exploris 120","2-hydroxy-3-methylbutyrate","untargeted metabolite profiling","experimental sample"],"mass_spectrometry_protocol":["The Orbitrap Exploris 120 mass spectrometer was used for its
ability to acquire MS/MS spectra on information-dependent acquisition (IDA) mode in the
control of the acquisition software (Xcalibur, Thermo). In this mode, the acquisition software
continuously evaluates the full scan MS spectrum. The ESI source conditions were set asfollowing: sheath gas flow rate as 50 Arb, Aux gas flow rate as 15 Arb, capillary temperature
320 ℃, full MS resolution as 60000, MS/MS resolution as 15000, collision energy: SNCE
20/30/40, spray voltage as 3.8 kV (positive) or -3.4 kV (negative), respectively.
"],"metabolite_name":["(2R)-2-amino-3-hydrosulfonylpropanoic acid","2-Fluoro-4'-hydroxybenzophenone","[1,1'-Binaphthalene]-8,8'-dicarboxylic acid","5-Methyldeoxycytidine diphosphate","(Z)-5-(4-Hydroxy-3-methoxybenzylidene)thiazolidine-2,4-dione","trans-zeatin riboside monophosphate","Carboxydextran","4-Cresol sulfate","3-Amino-4,4,4-trifluorobutyric acid","6-Thiouric acid","Ketoleucine","N-(1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide","Caplamin","GPEtn(16:0p/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","2,2',4,4'-Tetrahydroxybenzophenone","Methyl 3-(4-Methyl-2,5-dioxo-4-imidazolidinyl)propanoate","3beta-Acetoxy-19alpha-hydroxy-12-ursene","Glycolate","Benzenesulfonic acid, 3-amino-4-ethyl-","Iodo-gen","Hydromorphone-3-glucuronide","rel-5-[1-[(1aR,4R,4aR,7R,7aR,7bS)-Decahydro-4-hydroxy-1,1,4,7-tetramethyl-1H-cycloprop[e]azulen-7-yl]-3-methylbutyl]-2,4,6-trihydroxy-1,3-benzenedicarboxaldehyde","SM C16:1","Gallocatechin-(4alpha->8)-epigallocatechin","methyl (2E,8E)-9-[3a-hydroxy-6,7-dimethyl-1-(2-methylpropyl)-3-oxo-2,4,7,7a-tetrahydro-1H-isoindol-4-yl]-4,5-dihydroxy-8-methylnona-2,8-dienoate","4-Hydroxybenzaldehyde","TG(20:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/O-18:0)","2'-O-Methylguanosine","Chlorpheniramine maleate","[(2S,3R,4R,5S,6S)-3,5-dihydroxy-2-[[(1S,2S,4S,5S,6R,10S)-2-(hydroxymethyl)-10-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-5-yl]oxy]-6-methyloxan-4-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate","14,15-Lte4","2-[[2-[(2-Amino-3-carboxypropanoyl)amino]acetyl]amino]butanedioic acid","N3-(4-methoxyfumaroyl)-2,3-diaminopropanoate","Erionic acid E","4-(Trifluoromethyl)benzoic acid","(r)-3-Amino-4-methylpentanoic acid","Azocyclotin","Tetrahydrocorticosterone","2,3-Dihydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylic acid","(2R,3R,4S,5R)-2-(5,6-Dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol","(1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate","2-(1-Ethoxyethoxy)propanoic acid","5-Hydroxyhexanoic acid","1-16:0-2-18:2-phosphatidylinositol","N-Acetylneuraminic acid","Pantothenic acid","2-Propylglutaric acid","Hygric acid","3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene","Xanthurenic acid","DG(22:5(4Z,7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","6-Ethylmercaptopurine","Pyrrole-3-carboxylic acid","4-Methyl 2-oxobutanedioate","3-(Diphenylphosphoryl)propanoic acid","Acetylglycine","Loteprednol","(R)-5-Phosphomevalote","(4aS,5aS,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboximidic acid","5-phenyl-4-propyl-4H-1,2,4-triazole-3-thiol","Homoveratric acid","Prolylalanine","(20S,22S,25S)-22,25-Epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucoside","3-Dehydroquinic acid","Acetonitrile, (purin-6-ylthio)-","2-Phenyllactic acid","LysoPC(22:0/0:0)","(4S,5Z,6S)-4-(2-methoxy-2-oxoethyl)-5-[2-[(Z)-3-phenylprop-2-enoyl]oxyethylidene]-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylic acid","2-[[(2S)-2-azaniumyl-3-(4-hydroxyphenyl)propanoyl]amino]acetate","Trichlorophene","4-Acetamidobutyric acid","PG(16:1(9Z)/6 keto-PGF1alpha)","(-)-Mitragynine","4-(Methylamino)butanoic acid","Dantrolene","2-Naphthalenecarboxylic acid, 1-hydroxy-, methyl ester","Prostaglandin A2","Isocitric acid","Tetradecyl sulfate (sodium)","fructose-6-phosphate pyruvate","Cyhexatin","2-[[3-(4-Fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid","3-[(Acetyloxy)methyl]-7-[(4-carboxybutanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid","Adenosine","1-((3-(Trifluoromethyl)phenyl)sulfonyl)piperidine-4-carboxylic acid","Pro-Ile","2-[4-(2-Phenylpropan-2-yl)phenoxy]propanoic acid","3-Hydroxytetradecanedioic acid","Adenosine 3',5'-diphosphate (PAP)","3-Hydroxybutyric acid","Lithocholic acid 3-sulfate","Purine mononucleotide","3-Aminopentanoic acid","demethoxysulfazecin","Rebeccamycin","alpha-Amyrin cerotate","(2S,3S)-2-[[(2S)-2-azaniumyl-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoate","O-Acetylserine","3'-O-Methylguanosine","6-Benzyl-3-butan-2-yl-9-(7-hydroxy-6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone","Ceftolozane","Bis(glycerophospho)-glycerol","3-methyl-2-[[3,4,5,6-tetrahydroxy-2-oxohexylidene]amino]butanoate","gamma-Glutamylleucine","Sclerketide D","3-(3-Chlorophenyl)imidazolidine-2,4-dione","6,15-diketo-13,14-dihydroprostaglandin F1alpha","2-[5-[2-[2-[5-(2-Hydroxypropyl)oxolan-2-yl]propanoyloxy]propyl]oxolan-2-yl]propanoic acid","6-Hydroxy-1,3-benzoxathiol-2-one","Nitrofurazone","3,4-Dihydroanhydrorhodovibrin","alpha-D-Ribose 1,2-cyclic phosphate 5-phosphate","2,3-Dimethylmaleate","2-chloro-N-[2-(3,4-diethoxyphenyl)ethyl]-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxamide","1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine","Pulvomycin","2-Methylbutyrylglycine","2-(Hydroxymethyl)-3-(acetamidomethylene)succite","Niclosamide","9-(2,6-Dioxo-3H-purin-9-yl)-3H-purine-2,6-dione","Acridone","6-(3-Hydroxy-1-octenyl)-2-oxabicyclo[2.2.1]heptane-5-heptanoic acid","N-[4-(2-pyridinyl)-2-thiazolyl]cyclopentanecarboxamide","(S)-3-amino-2-methylpropanoic acid","Ethyl 3-(N-butylacetamido)propionate","Cheritamine","3-((Ethylphenylamino)methyl)benzenesulfonic acid","(2S)-2-[[(2R)-2-amino-4-carboxybutanoyl]amino]-4-methylpentanoic acid","5-Azacytidine","(2R)-6-amino-2-[[(2R)-2-amino-4-carboxybutanoyl]amino]hexanoic acid","Taurolithocholic acid","5-(2-chlorophenyl)-1H-pyrazole-3-carboxylic acid","3-methyl-1H-pyrazole-5-carbaldehyde","3-Methyl-2-oxovaleric acid","Desaminotyrosine","7-Methylguanine","1-20:2-2-18:3-phosphatidylethanolamine","cis-9-Palmitoleic acid","TG(16:0/24:0/O-18:0)","Iodoazomycin arabinoside","Methyl 4-(6,8-dihydroxy-3-methyl-1-oxoisochromen-7-yl)-2,4-dimethoxybutanoate","5,7-Dichloropyrazolo[1,5-a]pyrimidine","(2S)-2-[[(2S)-2-azaniumyl-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoate","Zidovudine Monophosphate","Fiacitabine","3,5-Dihydroxyphenyl beta-D-glucopyranoside","Glutathione disulfide","Succinyl-CoA","dADP","UDP-L-Ara4N","Cer(d16:1/20:4(6Z,8E,10E,14Z)-2OH(5S,12R))","DG(15:0/0:0/18:3n6)","Pipecolic acid","Phe-Val","4,5-Dimethoxy-1H-isoindole-1,3(2H)-dione","3-Bromosulfolane","Glucose 6-phosphate","D-Glucoside","2-[(2-Oxo-2H-chromene-3-carbonyl)-amino]-benzoic acid","2'-Deoxyuridine","Indole-3-carboxaldehyde","1-Octen-3-yl primeveroside","Ile-Val","Ethyl 4-hydroxybenzoate","O-Methylthreonine","Ala-Asp","(2S)-2-[[(2S)-2-azaniumyl-3-hydroxypropanoyl]amino]-3-hydroxypropanoate","m-(Trifluoromethyl)cinnamic acid","N-Methyl-L-asparagine","Unii-73hdp58zfk","7-[2-(1,2-Dihydroxy-3-oxooctyl)-3,5-dihydroxycyclopentyl]hept-5-enoic acid","2-Phenylbenzimidazole-5-Sulfonic Acid","3-Cyclohexyl-2-hydroxypropanoic acid","Mangiferin","Proanthocyanidin A2","Phosphatidylserines","Cetylpyridinium chloride","Cholesteryl caprylate","5-[5-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-6-methyloctanoyl]oxy-3-hydroxy-6-methyloctanoic acid","Sibiricose A6","Glyoxylic acid","4-Acetyl-3-Ethyl-5-Methyl-N-[2-Methyl-5-(Methylsulfamoyl)phenyl]-1h-Pyrrole-2-Carboxamide","3',5'-Cyclic IMP","1-Palmitoyl-2-linoleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)","Thymine","Stercobilin","Pelargonic acid","2-O-[2-O-(alpha-D-Mannopyranosyl)-alpha-D-glucopyranosyl]-3-phospho-D-glycerate","tetradecanedioate","3-[2-Methyl-5-(piperidine-1-sulfonyl)furan-3-yl]-1-phenylurea","Ethylene glycol dimethacrylate","(3E)-4-hydroxy-3-[hydroxy-[2-[(1E,3E)-6-hydroxyhepta-1,3-dienyl]-1,3,6-trimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]methylidene]-5-(hydroxymethyl)-1-methylpyrrol-2-one","4-chloro-5-ethyl-7H-pyrrolo[2,3-d]pyrimidine","1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine","LPG(18:1(9Z))","Maclurin","Retreversine","2,6-diamino-5-nitroso-1H-pyrimidin-4-one","1,1-Dichloro-2,2-bis(4-chlorophenyl)ethylene","methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate","Captafol","2-Isobutyl-1,3-dioxo-5-isoindolinecarboxylic acid","Verruculogen","Cholesterol iopanoate","Cholenate","Cholic acid 7-sulfate","N-(Carboxymethyl)-N-(phosphonomethyl)glycine","6-Nitro-2-(2-pyridyl)benzimidazole","Salicin","N6-(delta2-isopentenyl)-adenosine 5'-diphosphate","3,5-Dibromo-4-hydroxybenzamide","3-(1H-benzimidazol-2-yl)propanehydrazide","PIP(16:2(9Z,12Z)/18:1(12Z)-2OH(9,10))","cis-11-Eicosenoic acid","Boscalid","Piericidin C1","6-tert-butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine","PG(18:3(6Z,9Z,12Z)/PGJ2)","5-(4-fluoro-3-nitrophenyl)-2H-tetrazole","Fructose 1-phosphate","N-Acetylglutamine","3-Hydroxyvaleric acid","2-Aminobutyric acid","Anthemis glycoside A","Dehydrolithocholic acid","9-Hydroxynonanoic acid","PI(18:1/18:1)","3-Amino-5-sulfosalicylic acid","Glucosamine 1-phosphate","4,7-Epoxy-1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-","Prunin 6''-O-gallate","7-Hydroxy-3-phenyl-2-trifluoromethyl-chromen-4-one","2-Aminoadenosine","(1R,4S,5S,6S)-4-amino-2,2-dioxo-2lambda6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid","baumannoferrin B","CDP-glycerol","Monoethyl fumarate","norfuraneol","delta(17)-6-Ketoprostaglandin F1alpha","Eicosapentaenoic acid","(3R,2'S)-Myxol 2'-alpha-L-fucoside","Creatine","Bctc","5-Aminolevulinic acid","PS(DiMe(11,3)/MonoMe(11,5))","Ciprostene","(3-Oxopiperazin-2-yl)acetic acid","Glucosamine 6-sulfate","CDP-N-dimethylethanolamine","N-Phosphohypotaurocyamine","Dephospho-CoA","2'-Deoxyguanosine 5'-diphosphate (dGDP)","alpha-Neup5Ac-(2->6)-D-Galp","5-Hydroxyisourate","Ethanone, 1-(2,4-dihydroxyphenyl)-2-(4-fluorophenoxy)-","Chloroquine","1-20:0-2-18:1-phosphatidylserine","1-Palmitoyllysophosphatidate","2-(3,4-dihydroxyphenyl)ethyl (5Z)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl]-5-[2-[(E)-3-phenylprop-2-enoyl]oxyethylidene]-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylate","5-(2-chlorophenyl)-1H-pyrazol-3-amine","L-Lysine-L-valine","6-Oxocativic acid","6-Hydroxy-4-pyrimidinone","Bovinocidin","Flunoxaprofen","Glycerol triheptadecanoate","N-(2,5-dichlorophenyl)-2-hydroxybenzamide","Potassium metaphosphate","4-Amino-1-(2-deoxy-|A-D-erythro-pentofuranosyl)-5-methyl-2(1H)-pyrimidinone","cis-8,11,14-Eicosatrienoic acid","Glycohyodeoxycholic acid","Isoleucine","(6S)-1-((4-(Dimethylamino)-3-methylphenyl)methyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo(4,5-c)pyridine-6-carboxylic acid","Arachidonic acid (AA)","2-Methylhippuric acid","Acetoin","Povpc","Perfluorodecane sulfonic acid","N,N'-Ethylenedisalicylamide","Tetrahydromagnolol","Citraconic acid","PC(15:0/18:3(6Z,9Z,12Z))","Dehydroascorbic acid (Oxidized vitamin C)","4',6-Dihydroxyflavone","Zinc phosphide","1-[(Z)-but-2-en-2-yl]-3,9-dihydroxy-4,7-dimethylbenzo[b][1,4]benzodioxepin-6-one","2-Hydroxy-7-methoxy-5-methyl-1-phthoyl-CoA","Caproic acid","Dihydroxyacetone phosphate","sn-Glycerol 3-phosphate","15-cyclohexyl pentanor Prostaglandin F2alpha","GDP","DG(18:0/18:1(12Z)-O(9S,10R)/0:0)","Fenhexamid","9Z-Octadecenoic acid, (2S)-3-[(hydroxymercaptophosphinyl)oxy]-2-methoxypropyl ester","Methanethiosulfonate","Saccharopine","2-(5-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetic acid","4-Oxo-4-[(4-phenyloxan-4-yl)methylamino]butanoic acid","12-Ketochenodeoxycholic acid","Cytidylyl-(5'-3')-5'-inosinic acid homopolymer","Benzofep","Cer(d17:1/PGF2alpha)","O-Carbamoyladenylate","Ser-Ala","UDP-glucose","Tolclofos-methyl","Methyclothiazide","L-histidyl-L-leucine","Chlorthiamid","8-Acetyloxy-10-hydroxy-19-methoxy-1,9,18-trimethyl-15-oxo-16,20-dioxahexacyclo[15.3.2.02,13.04,12.07,11.014,19]docos-5-ene-5-carboxylic acid","Royal jelly acid","Threonylserine zwitterion","LysoPC(26:1(5Z)/0:0)","Bis(2-chloro-1-methylethyl)ether","2-Fluoro-4-biphenylboronic Acid","4-Oxosebacic Acid","4-Chloro-5-sulfamoylanthranilic acid","5-Fluoro-MN-18","3-Hydroxyoctanoic acid","PC(2:0/PGF1alpha)","6-Aminocoumarinhydrochloride","2-Aminobenzenesulfonic acid","Hydroxyphenyllactic acid","2-Mesatp","Alanine","2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine","gamma-Glutamylglutamine","Levulinic acid","4-Oxododecanedioic acid","Leiocarposide","Fructose 6-phosphate","JWH 018 N-pentanoic acid beta-D-Glucuronide","5-Fluoro-MN-24","Asparagine","Trandolaprilat","4'-Chloro-4-biphenylol","Triapine","lycotetraose","2-Amino-p-benzenedisulfonic acid","beta-nicotinamide adenine dinucleotide","5-Bromotryptophan","3-(2,5-Dioxopyrrolidin-1-yl)propanoic acid","3-(3-hydroxyphenyl)-2-phenylquinazolin-4(3H)-one","Quilseconazole","Adenosine monophosphate (AMP)","Epitheaflagallin 3-O-gallate","PS(18:3(6Z,9Z,12Z)/24:1(15Z))","2-[(Butoxymethyl)(2,6-diethylphenyl)amino]-2-oxoethanesulfonic acid","1,2-Di-(9Z,12Z,15Z-octadecatrienoyl)-3-(8-(2E,4Z-decadienoyloxy)-5,6-octadienoyl)-sn-glycerol","6-Benzyl-1-(benzyloxymethyl)-5-iodouracil","N1-Methyl-2-pyridone-5-carboxamide","N6-(1,2-Dicarboxyethyl)-AMP","Wedelolactone","s-Triazol-3-ol, 5-nitro-","Formylisoglutamine","Ethenocytosine","Pyruvaldehyde","N-(1-amino-1-oxo-3-phenylpropan-2-yl)-2-[[2-[(2-amino-3-phenylpropanoyl)amino]-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanamide","Leucine","Formyl-CoA","Ara-C triphosphate","(1R,3aS,5aS,5bR,11aR,13aR)-5b,8,8,11a-tetramethyl-9-oxo-1-prop-1-en-2-yl-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysene-3a,5a-dicarboxylic acid","3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholestan-26-oic acid","Finasteride carboxylic acid","Lorazepam glucuronide","Cymorcin diglucoside","alpha-Oxo-benzeneacetic acid","methyl 3-formyl-5,6-dimethoxy-1H-indole-2-carboxylate","6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione","DG(10:0/20:3(6,8,11)-OH(5)/0:0)","Dethiobiotin","N-(5-chloro-2-hydroxyphenyl)piperidine-4-carboxamide","N-(3-methoxyphenyl)-4-chlorocinnamanilide","N'-butyl-N-(pyridine-4-carbonylamino)carbamimidothioic acid","[6]-Gingerdiol 3,5-diacetate","cis-Linoleic acid","4'-Hydroxy Aceclofenac","Cer(d18:0/12:0)","ethyl 5-methyl-7-oxo-1H-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate","5,2'-O-Dimethyluridine","Thr-Phe","5-Bromo-4-fluoro-2-hydroxybenzoic acid","2,6-Dimethyl-4-hydroxybenzaldehyde","3-{[(1Z)-4-(4-hydroxyphenyl)phthalazin-1(2H)-ylidene]amino}phenol","pre-bisucaberin","Phosphoglycolic acid","2-(2H-Benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol","Indacrinone","Ethidium bromide","Vaccinoside.","2,4-Quinazolinedithiol","Salvianolic acid K","2-Ketocaproic acid","Thiolutin","Pamidrote","N-Acetylvaline","Pemirolast","uric acid citrate","4-Methyltriacontane","Magenta","2-{[(4-Fluorophenoxy)acetyl]amino}benzoic acid","5-(3,4'-dihydroxy-4,4,7,8a-tetramethyl-6'-oxospiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-3,8-dihydrofuro[2,3-e]isoindole]-7'-yl)pentanoic acid","(2S,3R,4aS,12bR)-2,3,4a,8-tetrahydroxy-12b-(5-hydroxy-6-methyloxan-2-yl)oxy-3-methyl-2,4-dihydrobenzo[a]anthracene-1,7,12-trione","(4Z,7Z,10Z,13Z)-nonadeca-4,7,10,13-tetraene-1-sulfonic acid","1-Methylxanthine","Cryptocyanin","3,4-Bis(7-chloroindol-3-yl)pyrrole-2,5-dicarboxylate","[2,6-dihydroxy-4-(7-methyl-11-oxo-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2,8-dioxatricyclo[7.3.1.0?,13]trideca-1(12),3,5(13),6,9-pentaen-3-yl)phenoxy]dihydroxyoxo-¦Ë?-sulfanylium","Mesaconic acid","alpha-Tocopherol (Vitamin E)","3'-Deoxydihydrostreptomycin 6,3-bis-phosphate","Lamotrigine","Imidazotetrazinone","(E)-4-[[(1R)-2-[[(2R)-2-(2-Adamantyloxycarbonylamino)-3-(1H-indol-3-yl)-2-methylpropanoyl]amino]-1-phenylethyl]amino]-4-oxobut-2-enoic acid","4-allyl-5-(2-methylphenyl)-4H-1,2,4-triazole-3-thiol","TG(22:0/20:4(5Z,8Z,11Z,14Z)/22:0)","Cholic acid/Muricholic acid, isoleucine-conjugated","3-Keto Fusidic Acid","LysoPE(P-16:0/0:0)","Arabinono-1,4-lactone","Monodehydroascorbate","3-(Methylsulphonylamino)benzoic acid","3-Hydroxyisobutyric acid","Oleic acid","7-Hydroxychroman-2-one","2,2-Bis(4-hydroxyphenyl)hexafluoropropane","Pseudouridine","Eltenac","Ochromycinone","beta-nicotinate D-ribonucleotide","2-Hydroxypalmitic acid","Tyr-Ser","4-Dimethyl-L-glutamic Acid","Guanosine","Isovaleric acid","Ribothymidine","Octafluorocyclobutane","Allyl chloride","3-Hydroxydecanoic acid","p-Nitrophenyl thymidine 5'-monophosphate","1-(tert-Butoxycarbonyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid","3-[6-[(E)-4,6-dimethyloct-2-en-2-yl]-5-methyloxan-2-yl]-4-hydroxy-5-(4-hydroxyphenyl)-1H-pyridin-2-one","3-Oxocholic acid","8-Acetamido-2-methyl-7-oxononanoic acid","Neuromedin B (1-3)","4-Ethyl-5-thiophen-2-yl-4H-[1,2,4]triazole-3-thiol","3-Methylxanthine","rac-2-Despiperidyl-2-amino Repaglinide","5-chloro-3-[(1E,3E)-3,5-dimethylhepta-1,3-dienyl]-7,8a-dihydroxy-1-methoxy-7-methyl-1H-isochromene-6,8-dione","Lactaldehyde","Hexadecanedioic acid","4-[(Phenylsulfanyl)methyl]benzoic acid","Ifosfamide","4-(4-Deoxy-beta-gluc-4-enuronosyl)-galacturonate","cis-Aconitate","Fenvalerate","4-O-Methyl-a-glucosyl-(1->2)-b-xylosyl-(1->4)-xylose","Cyclic 2,3-bisphospho-D-glycerate","Corynomycolic acid","1-Isopropyl-1H-benzoimidazole-5-carboxylic acid","Malonic acid","Lysylglutamic acid","Imazalil nitrate","5-cyclopropyl-2H-tetrazole","2-Hydroxyadenine","Trisodium nitrilotriacetate","TG(18:1(9Z)/20:1(11Z)/20:1(11Z))","9,10,11-Trihydroxy-(12z)-12-octadecenoic acid","3-Benzoyloxy-6-oxo-12-ursen-28-oic acid","3-Hydroxypropionic acid (beta-lactic acid)","S-(4-Bromophenyl)-mercaptopyruvate","[(6-amino-9H-purin-8-yl)sulfanyl]acetic acid","Gly-His","Ile-Ser","Glucuronic acid","4-Amino-1,3-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid","Phe-Lys","3-Methylglutaconic acid","2'-Fluoro-5-iodoarauracil","Benzoic acid, 2-[3,6-bis(acetyloxy)-2,7-dichloro-9H-xanthen-9-yl]-","4-methyl-N-(4-nitrophenyl)piperazine-1-carboximidothioic acid","17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2alpha","Allose","(S,S)-Formoterol","1,1-Diiodoethane","4-Methylquinolin-2-ol","3-Iodo-L-tyrosine","5'-Fluoro-2'-hydroxy-4-methoxychalcone","Phe-Pro","Melilotoside","dTDP-4-oxo-5-C-methyl-L-rhamnose","Mannose","Resorcinolnaphthalein","4-[(E)-3-[4,5-dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxybut-1-enyl]-4-hydroxy-3,5,5-trimethylcyclohex-2-en-1-one","Dodecyl gallate","Glycylproline","Eglumetad","Hydroiodic acid","8-Hydroxy-3-(7-hydroxyheptyl)-6-oxo-3,4-dihydroisochromene-7-carboxylic acid","[(E)-5-(2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl)-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate","Benzoic acid, 2-[4-(dipentylamino)-2-hydroxybenzoyl]-","PA(20:2(11Z,14Z)/LTE4)","5-Hydroxy Dantrolene","2-Bromo-5-hydroxy-N-[2-(4-hydroxyphenyl)ethyl]-4-methoxy-N-methylbenzamide","3-(5-chloro-1H-benzimidazol-2-yl)propan-1-amine","ZATOSETRON","(Z)-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoct-5-enoic acid","9,10-Epoxy-18-hydroxystearate","TTF-1","4,4'-Dichlorodiphenyl sulfone","Urocanic acid","S-(5-Hydroxy-2-furoyl)-CoA","N-Stearoyl Taurine","Nicotinamide adenine dinucleotide (NAD)","2,11,20,29,37,38,39,40-Octazanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetracontane","19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,10E,12E,16Z,18E-nonadecapentaenoic acid","2-[(3,6-Dihydroxy-5-methoxy-7-methyl-4-oxochromen-2-yl)amino]propanoic acid","Meclofemate sodium","2-(3-carboxy-4-chlorophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid","Flavodic Acid","TG(10:0/10:0/10:0)","3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid","cyclic IMP","(+)-Nortrachelogenin","3-methylsulfanyl-4-oxo-6,7-dihydro-5H-2-benzothiophene-1-carboxylic acid","Diethyl 2-((4-hydroxyanilino)methylidene)malonate","2,3,5,6,7,8-Hexahydro-3-(4-methylphenyl)-2-thioxo[1]benzothieno[2,3-d]pyrimidin-4(1H)-one","3,4-Dichloroaniline","Propofol glucuronide","3-Aminopentanedioic acid","Gln-Val","5-Aminopentanoic acid","5'-Deoxy-5-fluorocytidine","Valine","Rupatadine","1H-Indole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aR,7aS)-","N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide","TG(22:5(7Z,10Z,13Z,16Z,19Z)/20:4(5Z,8Z,11Z,14Z)/22:5(7Z,10Z,13Z,16Z,19Z))","Ketoprofen glucuronide","2-(2,3-Dichlorophenyl)phenol","Pesticide4_Ivermectin_C48H74O14_22,23-dihydroavermectin B1","Tritriacontane-16,18-dione","2-Aminoethyl diphenylborite","1-(5-Phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole","2-Methylthio-adenosine-5'-diphosphate","Bis(4-hydroxyphenyl)diphenylmethane","4-[2-[(1R)-1-(N-(4-Chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid","HLo7","Itaconic acid","2-(Phosphonomethyl)pentanedioic acid","8-oxo-GTP","Hydroxytyrosol acetate","Pterin","2-Hydroxy-3-methylbutyric acid","(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-hydroxy-4-prop-2-enylphenoxy)oxan-2-yl]methoxy]oxane-3,4,5-triol","Cytidine","Fluoroimide","5,7-Dihydroxy-3',4',5'-trimethoxyflavone","25B-Nboh","Di(2-thienyl)acetic acid","Digitoxigenin 3-[glucosyl-(1->6)-glucosyl-(1->4)-2,6-dideoxyribohexoside]","Angustmycin A","Melleolide M","3-Hydroxyisovaleric acid","2-[[4-Amino-2-(3-hydroxydodecanoylamino)-4-oxobutanoyl]amino]pentanediamide","2-Methyltetrahydrofuran-3-one","5-hydroxy-CTP","2-Hydroxyethanesulfonic acid","7-Ketolithocholic acid","1,2-dioctanoyl-1-amino-2,3-propanediol","2-Dec-9-enyl-3-hydroxypentanedioic acid","2,4,6-Trihydroxybenzophenone","Pantoic Acid","2-AminoAMP","Chenodeoxycholic acid 24-acyl-beta-D-glucuronide","3-Hydroxyoctadecanoic acid","8-Hydroxydesmethylclomipramine","Allantoin","Ala-Val","2-methylcitrate","Phosphatidylinositols,soya","6-Hydroxynorleucine","Glycinoprenol 11","N-Hydroxy-2-phenylindole","Phosphoenolpyruvate","beta-Alanine","4-(4-Oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoic acid","1-palmitoleoyl-sn-glycero-3-phosphoethanolamine","N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine","Cer(t18:0/16:0)","Calcium pantothenate, calcium chloride double salt","D-valyl-aspartic acid","ORG 20599","H-Tyr-val-OH","DG(15:0/0:0/20:4n6)","1,7-Bis(4-hydroxyphenyl)-5-methoxy-3-heptanone","33-Deoxy-33-hydroperoxyfurohyperforin","Nitrogen mustard","Bromacil","Fostriecin","Cholesteryl sulfate","CMP-N-glycoloylneuraminate","Qingyangshengenin","3-Hydroxy-4'-methyl-2-naphthanilide","3-methylheptanedioyl-CoA","Brimonidine","3-(3-(3,4-Dihydroxy-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-2-yl)propanoyl)benzoic acid","gamma-Glutamylglutamic acid","Vigabatrin","Phosphate","3-Methylcrotonylglycine","15-(3,4-Dimethyl-5-pentylfuran-2-yl)pentadecanoylcarnitine","Pentadecanoic acid","Xylobiose","8-Azido-cyclic AMP","6-(2-(5-Chloro-2-(((2,4-difluorophenyl)methyl)oxy)phenyl)-1-cyclopenten-1-yl)-2-pyridinecarboxylic acid","3-Phenylpropanoic acid","6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazin-3(2H)-one","TG(15:0/20:0/22:4(7Z,10Z,13Z,16Z))","Fezaflor","Phe-Leu","PS(24:0/18:1(12Z)-2OH(9,10))","TG(16:0/20:0/20:0)","Britanin","glutathione amide perthiol","2-[[2-[(2-Amino-4-methylpentanoyl)amino]acetyl]amino]-4-methylpentanoic acid","Glu-Glu","2-(1,2-dihydroxy-2-phenylethyl)-3-hydroxy-2,3-dihydropyran-6-one","5-Chloro-3,4-dihydroquinazolin-4-one","Cyanin","(2S)-2-[[(2S)-2-azaniumyl-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoate","Indolelactic acid","4-chloro-8-methoxy-5H-pyrimido[5,4-b]indole","Sodium phosphate (Na(H2PO4))","Maltotetraose","(E)-4-[3-[(E)-hept-1-enyl]-2,5-dihydroxy-4-(hydroxymethyl)-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid","Atropic acid","L-phenylalanyl-L-glutamic acid","Dicyclohexylglycolic acid","N-ethyl-4-hydroxy-N-phenylbenzenesulfonamide","2-(Methylsulfanyl)-6-(trifluoromethyl)pyrimidin-4-ol","Mallotinic acid","3-Methyluridine","Potassium dichromate","(2R)-3-{[(2,3-dihydroxypropoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate","6-(4-Methylpiperazin-1-yl)-9H-purin-2-amine","CE(17:1)","3-methoxy[1]benzothieno[2,3-c]quinolin-6(5H)-one","Myristic acid","Nb-Feruloyltryptamine","Hypoxanthine","3,4-Dihydroxymandelate","1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide","Kanokoside D","glutathione sulfinate","PE(18:0/20:4(5Z,8Z,11Z,14Z))","Benurestat","LPE(18:1(9Z)/0:0)","2-Hydroxybutyric acid","2,4-Dihydroxy-5-tert-butylbenzophenone","Prodelphinidin A1","Phe-Tyr","Isorhamnetin 7-glucoside","2-Ethyl-2-hydroxybutyric acid","(E)-4-(6,8-dihydroxy-3-methyl-1-oxoisochromen-7-yl)-2-methoxybut-3-enoic acid","Adenine","20-Cooh ltb4","Gly-Phe","PG(20:3(5Z,8Z,11Z)/LTE4)","Methylimidazoleacetic acid","12,13-epoxy-9-alkoxy-10E-octadecenoate","2-Iodohippuric acid","(Z)-1-[4-(4-Diethylaminobutoxy)phenyl]-1,2-diphenyl-2-chloro-ethylene","Leu-Ile","Adenosine 5'-diphosphate (ADP)","Bellericagenin B","2-Amino-3-({hydroxy[2-(icosanoyloxy)-3-[octadec-11-enoyloxy]propoxy]phosphoryl}oxy)propanoic acid","Behenoyl-arabinofuranosyl-cytosine","[6-[[6-[3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-3,4,5-trihydroxyoxan-2-yl]methyl (E)-2-methylbut-2-enoate","1-Iodobutane","(6-chloro-1H-benzo[d]imidazol-2-yl)methanol","Ethyl 3-hydroxybenzoate","Benzoic acid, 4,4'-(3-oxo-1(3H)-isobenzofuranylidene)bis-","Acetylleucine","Allocholic acid","Iodate","2-[(4-chlorophenyl)formamido]-3-(1H-indol-3-yl)propanoic acid","Maltotriose","Valproic acid","3-O-Methylquercetin","Cucurbitacin E","Dichlormid","D-Ribitol 5-phosphate","(4S,4aS,12aS)-4-(dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide","PS(20:4(5Z,8Z,11Z,14Z)/6 keto-PGF1alpha)","Okaramine B","Nicotinamide","SB 228357","N-Lactoylleucine","7-Ketodeoxycholic acid","Zizybeoside II","2-(N-methylmethanesulfonamido)acetic acid","Safflomin A","Sodium glucoheptonate","AF Toxin II","Eujambin","Dynasore","Mannitol","Pyroglutamic acid","TG(20:1(11Z)/O-18:0/20:1(11Z))","4-Amino-4-methylpentanoic acid","DG(17:0/6 keto-PGF1alpha/0:0)","PE-NMe2(16:0/24:1(15Z))","Prostaglandin B2 (PGB2)","Taurocholic acid 3-sulfate","Equisetin","Isomaltose","EDTA","Fraxin","Deoxyguanosine","2,3-Dihydroxy-3-(2-hydroxypropan-2-yl)-8a-methyl-1,2,3a,4,5,8-hexahydroazulene-6-carboxylic acid","Tauro-beta-muricholic acid","[5-(Aminomethyl)furan-3-yl]methyl diphosphate","(+-)-2-Hydroxyisocaproic acid","Lactate","Bropirimine","6-(4-Chloro-phenylamino)-1H-pyrimidine-2,4-dione","6-[4,5-Dihydroxy-6-(hydroxymethyl)-3-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one","6-(1,2-Dihydroxypropan-2-yl)-13-hydroxy-16,17-dimethoxy-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one","1-(2,3-Dichlorophenyl)ethanamine","Glu-Thr","Ursodeoxycholic acid","3-Hydroxysebacic acid","2-benzylsulfanyl-6-phenyl-1H-pyrimidin-4-one","1,2-Dilinoleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)","1-mercapto[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one","N-Tigloylglycine","Malic acid","Cer(d20:1/18:1(12Z)-2OH(9,10))","(2S)-2-[(1R)-1-carboxyundecyl]-5-oxooxolane-2-carboxylic acid","Chlorophyll","thyroxine iodide","(2S)-2-[[(2S,3S)-2-azaniumyl-3-methylpentanoyl]amino]-4-methylsulfanylbutanoate","phosphatidylglycerolphosphate (1,2-di-stearoyl)","1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoserine","7-Mercapto-4-methylcoumarin","Ethyl 4-nitrophenyl methylphosphonate","Iodothyronine sulfate","Bisphenol A bis(chloroformate)","DG(16:0/0:0/22:2n6)","Isrib","Gulono-1,4-lactone","1-[4,5-dihydroxy-6-(hydroxymethyl)-3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxyoxan-2-yl]oxy-6-hydroxy-7-methylidene-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyran-4-carboxylic acid","12-Hydroxystearic acid","Diglycine","p-Toluquinone","Butanoic acid","5-Phenyl-1H-tetrazole","20-Carboxyleukotriene B4","(2S)-2-[(2R,3S,7R,8R,8aS)-2,3,4'-trihydroxy-4,4,7,8a-tetramethyl-6'-oxospiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-3,8-dihydrofuro[2,3-e]isoindole]-7'-yl]-3-methylbutanoic acid","Taurodeoxycholic acid","Bromazepam","Alnusiin","TG(22:0/22:4(7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Nicotinate","1-14:0-2-lysophosphatidylserine","(2S)-2-[[(2R)-2-amino-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid","Deoxycholic acid","(+)-gamma-Tocopherol","PC(22:0/18:1(12Z)-O(9S,10R))","PGP(20:1(11Z)/20:3(8Z,11Z,14Z)-2OH(5,6))","Prochlorperazine mesylate","Carbamoyl phosphate","Nedaplatin","2-Methoxy-5-nitrophenol","(Benzothiazole-2-sulfonyl)-acetic acid","Chloramphenicol succite","9-Methyl-7-bromoeudistomin D","3,5-Dinitrobenzoic acid","N-(6-chloro-1,3-benzothiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide","3,6-Dioxo-5alpha-cholan-24-oic acid","DG(14:1n5/0:0/16:1n7)","N-(thiophen-2-ylmethyl)-7H-purin-6-amine","4-Chloro-N-[5-methyl-2-[7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl]-3-pyridyl]-3-(trifluoromethyl)benzenesulfonamide","2-Keto-3-deoxygluconic acid","1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoserine","Val-Met","Pseudoaconitine","Anhydrochlortetracycline","beta-2,3,5,6-Tetrachloro-1,4-cyclohexanediol","Polidocanol","(2R,3S,4aS,7R,8R,8aS)-2,3,4'-trihydroxy-4,4,7,8a-tetramethylspiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-7,8-dihydro-3H-furo[2,3-e]isoindole]-6'-one","2',3,4,4',6'-Pentahydroxychalcone","4,18-Dihydroxy-15-(3-hydroxy-3-methylbutyl)-2-methoxy-7,9,13-trioxapentacyclo[10.8.0.03,10.04,8.014,19]icosa-1,3(10),5,11,14,16,18-heptaen-20-one","Chloranocryl","Citrulline","2-[[2-[(2-Amino-3-hydroxybutanoyl)amino]-3-methylbutanoyl]amino]-4-methylpentanoic acid","DG(15:0/20:3(5Z,8Z,11Z)-O(14R,15S)/0:0)","Capric acid","CE(LTE4)","cis-?9,?10-?Epoxystearic acid","Salubrinal","Podophyllotoxin, glucoside","Perfluoroheptanoic acid","(2R)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide","1,3-Di-(octadec-9Z-enoyl)-1-cyano-2-methylene-propane-1,3-diol","(2R)-6-amino-2-[[(2R)-2-amino-4-methylpentanoyl]amino]hexanoic acid","Cer(d18:1/PGJ2)","Arginine","Glutathione","Salviaflaside methyl ester","Altropane","Hydroferulic acid","5-ethyl-N-phenylpyridine-2-carbothioamide","Maltopentaose","2,7-Dihydroxy-4-trifluoromethylquinoline","6-Benzyl-3-butan-2-yl-9-(7,8-dihydroxy-6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone","Telotristat","Galactono-1,4-lactone","3-(2-Hydroxyphenyl)propanoic acid","Pro-Gly","5-[(2-chlorophenoxy)methyl]-4-methyl-4H-1,2,4-triazole-3-thiol","D-glucaro-1,4-lactone","1-(3-Mercaptopropanoyl)-6-methylpiperidine-2-carboxylic acid","3,5-Di-O-galloyl-4-O-digalloylquinic acid","Seryl-proline","Allolithocholic acid","Phe-Gln","Taxine B","Leu-Val","Taurohyodeoxycholic acid","Erucic acid","N-(1h-Benzimidazol-2-Yl)-3-(4-Fluorophenyl)-1h-Pyrazole-4-Carboxamide","O-Acetyl-ADP-ribose","Kaempferol 3,7,4'-trimethyl ether","TG(18:1(11Z)/22:5(4Z,7Z,10Z,13Z,16Z)/18:1(11Z))","9-hydroxy-2,6,12-trimethyl-12-[2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethyl]-15-oxatetracyclo[8.4.1.01,10.02,7]pentadecane-6-carboxylic acid","Phthalic acid","4-[(4-Acetyloxyphenyl)carbonylamino]benzoic acid","N-(2-Oxo-2,3-Dihydro-1h-Benzimidazol-5-Yl)glycinamide","L-Selenocysteine","TG(15:0/22:0/O-18:0)","Docosapentaenoic acid (DPA)","1-[(Z)-but-2-en-2-yl]-3,9-dihydroxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-2-carboxylic acid","4'-Acetoxy-7-hydroxy-6-methoxyisoflavone","TG(20:0/20:0/20:0)","L-Selenocystathionine","1-(4-chlorophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid","N-Palmitoyl Taurine","1-Octadecanoyl-sn-glycero-3-phosphoethanolamine","10-Methylpentacosanoylcarnitine","(1R,8S,9S)-3,4-dihydroxy-8-methoxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6-trien-15-one","H-Gly-Pro-Arg-Pro-NH2","PS(15:0/22:4(7Z,10Z,13Z,16Z))","Serine","Erythrityl Tetranitrate","cis-11.14-Eicosadienoic acid","(S)-3,5-Dihydroxyphenylglycine","Alnusone","4-O-acetyl-N-acetylmannosamine","Phenylsulfate","Gln-Asp","8-Geranylumbelliferone","6,6'-Dihydroxy-5,5'-dimethoxybiphenyl-3,3'-dicarboxylic acid","Melphalan","2-(4-methoxyphenyl)ethyl 6-O-a-L-arabinopyranosyl-b-D-glucopyranoside","TAPI (inhibitor)","1-Amino-9,10-dihydro-9,10-dioxo-4-(phenylamino)-2-anthracenesulfonic acid","Aminoimidazole ribotide","13,14-Dihydro-15-keto-pgd2","1,3,4-trihydroxy-5-[(E)-3-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]prop-2-enoyl]oxycyclohexane-1-carboxylic acid","TG(24:0/20:3(5Z,8Z,11Z)/O-18:0)","Uric acid","Tcpobop","{[5-(2-Furyl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetic acid","2-[3-[(E)-6-acetyloxy-2-hydroxy-6-methyl-3-oxohept-4-en-2-yl]-6-(carboxymethyl)-2-hydroxy-3a,5a,9b-trimethyl-5-oxo-2,3,4,6,9,9a-hexahydro-1H-cyclopenta[a]naphthalen-7-yl]-2-methylpropanoic acid","(3,5-Dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate","DL-Norvaline","7-[1-benzyl-3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxoimidazolidin-4-yl]heptanoic acid","PIP2(16:0/16:1(9Z))","Cyclopropylacetic acid","2-[(2E,6E,10E)-14,15-dihydroxy-3,7,11,15-tetramethylhexadeca-2,6,10-trienyl]-2,4,6,9-tetrahydroxy-5,7-dimethylphenalene-1,3-dione","Udp xylose","Benzoic acid","3-Sulfamoylbenzoic acid","Ascorbic acid","Quercetin 3,4'-dimethyl ether","Methylsuccinic acid","Bis-gamma-glutamylcystine","6-(3-Chlorobenzylamino)purine","pGlu-Glu-Pro Amide, >=97% (HPLC)","2-[4-(Trifluoromethoxy)phenyl]cyclopropane-1-carboxylic acid","Auristatin E","N-(Tetradecanoyl)-sphing-4-enine","(Z)-6,7-Dichloro-3-(hydroxyimino)indolin-2-one","Cytidine monophosphate N-acetylneuraminic acid","2-Fluoro-1-nitroimidazole","6-Formylpterin","Ethyl Sulfate","1-Carboxycyclohexaneacetic acid","2-Ketobutyric acid","Isodeoxycholic acid","3,4-Bis(trifluoromethyl)-1H-pyrazole","1-formyl-L-proline","GDP-alpha-D-glucose","Valeric acid","(2S)-1-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy-3-phenylpropan-2-amine","B Lewis b","6-Sialyllactose","1H-imidazole-4,5-dicarbohydrazide","13,17-Dihydroxy-6-(3-hydroxyprop-1-en-2-yl)-16-methoxy-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one","methyl 3-acetyloxy-16-hydroxy-10-(hydroxymethyl)-4,4,8,12,13,16-hexamethyl-15,17-dioxo-2,3,5,6,7,9-hexahydro-1H-cyclopenta[a]phenanthrene-14-carboxylate","4-Nitroaniline","Trehalose","Fluzinamide","alpha-Ketoglutaric acid (alpha-KG)","Bacampicillin hydrochloride","Calcium arsete","(2S)-2-[[(2R)-2,4-diamino-4-oxobutanoyl]amino]-3-methylbutanoic acid","Phosphinic acid, imino(di-o-phenylene)-","Isocil","N-Acetylphenylalanine","Cytidine 5'-monophosphate (CMP)","TG(22:0/15:0/22:0)","Didecyldimethylammonium chloride","4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethylbenzene-1,3-diol","2-Hydroxyoctanoic acid","Xanthosine","Cysteine-glutathione disulfide","N-Acetylglucosamine 4-sulfate","(15Z)-9,12,13-Trihydroxy-15-octadecenoic acid","5,7,3',4'-Tetrahydroxy-3,6,8-trimethoxyflavone","(3Z)-3-[[5-(2-methylbut-3-en-2-yl)-1H-imidazol-4-yl]methylidene]-6-propan-2-ylpiperazine-2,5-dione","Citric acid","Glycylleucine","Mannose 1-phosphate","Soravtansine","SM(d18:0/22:1(13Z))","TG(18:0/22:2(13Z,16Z)/18:0)","2-16:1-lysophosphatidylglycerol","(3beta,9xi)-3-(beta-D-Glucopyranosyloxy)-14-hydroxycard-20(22)-enolide","IAA-94","9-Methoxycarbonyldec-9-enoic acid","(2S,3S)-2-[[(2R)-2-aminopropanoyl]amino]-3-methylpentanoic acid","1-(5-Fluoropentyl)-3-(2-iodobenzoyl)indole","Tauroursodeoxycholic acid","Inosine 5'-monophosphate (IMP)","Glycocholic acid","Pseudolaric Acid B","pyruvate carbon","N6-Monobutyryl-cAMP","Calcium ascorbate","Lopirazepam","2-(2,6-difluorophenyl)-1H-benzimidazole","8-Methyl-6-nonenoic acid","2-[2,6-bis(3-methylbut-2-enyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2-hydroxyacetic acid","Dibutyl adipate","4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]butanoic acid","Bisphenol S","1-Carboxyvinyl carboxyphosphote","Glutamate","3'-(2'',3''-Digalloylglucosyl)-phloroacetophenone","3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid","Bisphenol C","(+-)-1,1'-Binaphthyl-2,2'-diyl hydrogen phosphate","PE(18:1(11Z)/P-18:1(11Z))","Urate D-ribonucleotide","4-(N-Maleimido)benzyltrimethylammonium iodide","(-)-Chicoric acid","Pyrazolopyridine analog","Alanylalanine (Ala-Ala)","5-[(Chloroacetyl)amino]-2-hydroxybenzoic acid","Fluoroacetyl-CoA","2,2,2-Trichloroethyl chloroformate","L-Aspartic acid, L-leucyl-","Estramustine phosphate sodium","1-linoleoyl-sn-glycero-3-phospho-(1'-sn-glycerol)","5-Methylhexanoic acid","Octadec-9-ene-1,18-dioic-acid","N-acetylmuramoyl-ala-glu","2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]piperazin-1-yl]pyrimidine","3-(4-hydroxy-5-oxo-3-phenyl-2H-furan-2-yl)propanoic acid","(2E,4E)-N-[2-(4-hydroxyphenyl)ethyl]dodeca-2,4-dienamide","{[(2R,3S,4R,5S)-3,4,5,6-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]methoxy}phosphonic acid","N-(2-benzamido-1,3-benzothiazol-6-yl)adamantane-1-carboxamide","2-[(2R,4aS,8S,8aS)-8-[2-[(4aS,7R,8aR)-7-(1-carboxyethenyl)-1-hydroxy-4a-methyl-2-oxo-6,7,8,8a-tetrahydro-5H-naphthalen-1-yl]ethyl]-4a-methyl-7-oxo-1,2,3,4,8,8a-hexahydronaphthalen-2-yl]prop-2-enoic acid","Tryptophanyl-glutamine","4'-Chlorodiazepam","[2-(1H-tetrazol-5-yl)phenoxy]acetic acid","2-Acetylaminofluorene","2-Hydroxyglutaric acid","7-Hydroxy-4-(3-trifluoromethylphenyl)coumarin","Se-Propenylselenocysteine Se-oxide","Glycerone phosphate","Bis-tris propane","(2S)-4-hydroxy-2-(2-hydroxypropan-2-yl)-7-methyl-2,3-dihydrofuro[3,2-g]chromen-5-one","4-Hydroxyisoleucine","Dimethylbarbituric acid","Amlaic acid","4-Hydroxyphenylacetic acid","Galactose","16-Hydroxypalmitic acid","beta-Alanyl-L-lysine","Taurine","Tetracozole","N-Acetylgalactosamine","Amastatin","5-(4,6-Dichlorotriazinyl)aminofluorescein","2-(2-Butoxyethoxy)acetic acid","5-Methyl-2-oxo-1,3-oxazolidine-4-carboxylic acid","2-Aminonicotinic acid","Triphosphate","Se-Adenosylselenomethionine","Maltobionate","PIP(16:0/18:0)","Cns-5161","19-Noretiocholanolone glucuronide","Procymidone","1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline","Hexaflurate","2-Hydroxy-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one","n-(4-Cyanophenyl)-4-methylbenzenesulfonamide","2,4-DB","SWEP","Cetirizine","4'-Chloro-2-hydroxy-4-methoxybenzophenone","6-Nitro-3,4-dihydro-1,2,3-benzotriazin-4-one","Monobromobisphenol A","trans-Vaccenic acid","2,3,6,8-Tetrahydroxy-1-methylxanthone","Lippioside I","(2R,3R,4S,5S,6R)-2-octoxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxane-3,4,5-triol","Undecanoic acid","1,1,1,2-Tetrafluoroethane","5'-Methylthioinosine","2'-Hydroxy-4-methylchalcone","1-[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide","Roquefortine","UDP-D-xylose","2-(carboxymethyl)oxirane-2,3-dicarboxylic Acid","Butyrolactone 3","cytosyl-alpha-arabinopyranose","Val-Ile","1-Heptadecanoylglycerophosphoethanolamine","6-(pyrrolidin-1-yl)-9H-purine","Asp-Cys","(E,3R,5S)-7-[(6R,8S)-8-acetyloxy-2,6-dimethyl-5,6,7,8-tetrahydronaphthalen-1-yl]-3,5-dihydroxyhept-6-enoic acid","3-(2-Glucosyloxy-4-methoxyphenyl)propanoic acid","2-[[(2S,3R)-2-azaniumyl-3-hydroxybutanoyl]amino]acetate","Phenylalanine","Teflubenzuron","Ferrichrome","(2R,3S,4S,5R,6R)-2-[[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[2-(4-hydroxyphenyl)ethoxy]oxane-3,4,5-triol","Lauryl sulfate","Pyrogallol","Osaterone acetate","D-Glucosamine, 6-sulfate","Xanthoxylin","Uracil","Geshoidin","(2S)-5-amino-2-[[(2R)-2-amino-3-hydroxypropanoyl]amino]-5-oxopentanoic acid","Tubulysin D","(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-2-(3-hydroxy-6-methylheptoxy)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol","p-Hydroxybenzoylecgonine","PE(18:4(6Z,9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","Zoledronate","[(2S,3R,4R,5S,6S)-4-acetyloxy-2-[[(1S,2S,4S,5S,6R,10S)-10-[(2S,3R,4S,5S,6R)-3-acetyloxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-5-yl]oxy]-5-hydroxy-6-methyloxan-3-yl] (E)-3-(4-hydroxyphenyl)prop-2-enoate","Caprylic acid","IDP","2-[1-[4,5-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]indol-3-yl]acetic acid","Biochanin A 7-O-(6-O-malonyl-beta-D-glucoside)","2,3-Pentanedione","methyl 3-acetyloxy-10-formyl-16-hydroxy-4,4,8,12,13,16-hexamethyl-15,17-dioxo-2,3,5,6,7,9-hexahydro-1H-cyclopenta[a]phenanthrene-14-carboxylate","cis-4,10,13,16-Docosatetraenoic Acid","Auranofin","7-Methylinosine","1-(4-Hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide","Thiazolidine-2-carboxylic acid","Guanidinosuccinic acid","(9Z,12E)-15,16-Dihydroxyoctadeca-9,12-dienoic acid","3alpha-Hydroxy-12-oxo-5beta-cholan-24-oic acid","Pentafluoropropionic anhydride","3-Hydroxylauric acid","4-Aminothiane-4-carboxylic acid","Pregnenolone sulfate","2-Bromo-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol","Hibifolin","2-(4-(2-((3,5-Dichlorophenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid","Cytidylyl-(3',5')-guanosine","dTTP","Perfluorovaleric acid","2,3-Dinitrobenzamide","3-hydroxybenzaldehyde","ethyl 6-ethyl-4-oxo-1H-quinoline-3-carboxylate","N-Eicosapentaenoyl Glutamic acid","Glycylmethionine","Val-Val","LPC(13:0)","Lapaquistat acetate","Mobocertinib","Lovastatin Acid","4,4'-Methylene-bis-(2-chloroaniline)","UDP-N-acetylglucosamine","5,5,5-Trifluoro-DL-norvaline","2-Methyl-3-hydroxybutyric acid","Pyruvate","Threonic acid","Fructose","Dinicozole","Heptadecanoic acid","Cytidine 5'-diphosphocholine (CDP-choline)","4-(dimethylamino)butanoate","2-[Bis(5-methylfuran-2-yl)methyl]-6-bromo-4-nitrophenol","Glutamine","3-Hydroxyphenylacetic acid","7-[2-O-(6-O-Acetyl-beta-D-allopyranosyl)-beta-D-glucopyranosyloxy]-5,8-dihydroxy-4'-methoxyflavone","Palmitoylglycine","cyclic- 3,4-O-oxalyl-L-threonate","Palmitic acid","2-(3,7,11,15,19,23,27-Heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione","Histidine","Prothiofos","3-Chloromandelic acid","3-(5,8-Dimethoxy-1,4-dioxonaphthalen-2-yl)sulfanylpropanoic acid","Dimefline hydrochloride","Hydroxysydonic acid","Propionic acid","Dihydromethanophezine","Glyco-beta-muricholic acid","2-[(4-hydroxy-2-methylphenyl)[(1Z)-2-methyl-4-oxocyclohexa-2,5-dien-1-ylidene]methyl]benzene-1-sulfonicacid","Gly-Val","3,3-Di(1H-indol-3-yl)propane-1,2-diol","Edetate disodium","Docosahexaenoic acid (DHA)","Vinclozolin","Dichlozoline","N-Glycolylneuraminic acid","Ribose-1-arsenate","3-(3,5-Dichlorophenyl)-4-hydroxy-1,3-thiazol-2-one","CDP-DG(16:0/20:4(5Z,8Z,11Z,14Z))","Formylmethionine","1-tetradecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine","Calcium palmitate","Thr-Leu","1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-ol","Indoleacetic acid","glucuronamide","N-Methylglutamic acid","(2E)-1-(2,6-Dihydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one","Jurubine","2,6-Di-tert-butylphenol","Maysin 3'-methyl ether","8-Methyltheophylline","4-Sulfobenzoate","1,1-Dioxo-1lambda6-thiolane-3-carboxylic acid","N-Lactoylphenylalanine","N-Acetylhistidine","2-Methylguanosine","Xanthine","19,20-DiHDPA","2,6-Di-tert-butyl-4-methylphenol","6-Aminosaccharin","3H-spiro[1,3-benzothiazole-2,3'-indol]-2'(1'H)-one","3-Chloro-1H-indazole","(8R,8'S,10'R)-4,4,11',11',14'-pentamethylspiro[10H-[1,4]dioxepino[2,3-g]indole-8,12'-3,14-diazatetracyclo[6.5.2.01,10.03,8]pentadecane]-9,15'-dione","1-Stearoylglycerophosphoserine","1-hydroxy-1-(hydroxymethyl)-8,8-dimethyl-2-oxo-4a,6a,7,9-tetrahydro-4H-pentaleno[1,6a-c]pyran-5-carboxylic acid","3-[(1E)-2-nitroprop-1-en-1-yl]-1H-indole","Leucylphenylalanine","hydroxynefazodone","Lulicozole","PG(16:0/18:1)","PE(22:5(4Z,7Z,10Z,13Z,16Z)/P-18:1(11Z))","Quisinostat","3-Hydroxypyruvic acid","Maleic acid","Flavin adenine dinucleotide (FAD)","Gluconic acid","7-Methylxanthine","3-Amino-4-methylpentanoic acid","Indoxyl sulfate","S-Adenosylhomocysteine","2-Hydroxy-2-methylbutyric acid","3,5-Dihydroxydecanoic acid","Methyl 4-hydroxy-3,5-dinitrobenzoate","Isovalerylglycine","2-[[2-[(2-Amino-3-methylpentanoyl)amino]acetyl]amino]-3-methylpentanoic acid","PGP(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","7-O-Galloyl-sedoheptulose","N-Cyclohexyl-1,6-dihydro-N-methyl-6-thioxo-3-pyridinesulfonamide","dehydrofelodipine","6-Hydroxy-5-methoxy-11-methyl-3-propan-2-ylidene-2,9-dioxatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12)-tetraen-10-one","4-Hydroxyphenylpyruvic acid","N-[3-(trifluoromethyl)phenyl]benzenesulfonamide","Hydnocarpic acid","1-(3,4-Dichlorophenyl)urea","6'-Sialyl-N-acetyllactosamine","N-acetylgalactosamine 4-sulfate","Haloxydine","3-Amino-5-(methylthio)pyrazole-4-carbonitrile","Photomirex","Dibromobisphenol A","2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine","1-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione","TG(18:0/20:0/20:1(11Z))","Pyridoxal phosphate","3alpha-Hydroxy-6-oxo-5alpha-cholan-24-oic acid","Icilin","3-[(2,4-Dimethoxyphenyl)amino]-3-oxopropanoic acid","L-3,4-Dihydroxybutan-2-one 4-phosphate","Taurine glutamate","2'-Deoxyguanosine 5'-monophosphate (dGMP)","Manghaslin","2-Pyrimidinylacetic acid","Deoxyinosine","Mercaptoethanesulfonic acid","(4E)-4-(2-amino-4-oxo-1H-imidazol-5-ylidene)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one","Phaclofen","Reduced 2,6-Dichlorophenolindophenol","Pyriprole","Aminocyclopyrachlor","2-[(2R)-2-hydroxycyclohexyl]acetic acid","2-(5-chloro-2-methyl-1H-indol-3-yl)ethanamine","2-(2-Nitrophenoxy)propanoic acid","Anthraniloyl-CoA","Paxilline","Octadecanedioic acid","Bromucozole","Amberlite CG 400","E-Phenylitaconyl-CoA","1-Carbobenzoxy-2-piperidinecarboxylic Acid","N-Acetylaspartic acid","Tianeptine","25-Methyl-21-tritriacontene-1,9,11-triol","(2Z,6E,10Z)-12-acetyloxy-10-(acetyloxymethyl)-6-methyl-2-(4-methylpent-3-enyl)dodeca-2,6,10-trienoic acid","Hexafluoroacetylacetone","AMPHOTERICIN B METHYL ESTER","1-(4-Isopropylphenyl)-5-oxopyrrolidine-3-carboxylic acid","PA(10:0/5-iso PGF2VI)","Creatinine oxalate","Tetrahydro-5-oxofuran-2,3-dicarboxylic acid","Glycine","Cycloolivil","1,4-Bis(chloromethoxymethyl)benzene","Glutaric acid","2',3'-Dideoxythymidine triphosphate","(2-Amino-2-oxoethyl)phosphinous acid","(2S)-3-methyl-2-[[(2R)-5-oxopyrrolidine-2-carbonyl]amino]butanoic acid","3,5-Dinitroguaiacol","Indole, 5-bromo-3-(dimethylamino)methyl-","Adenylsuccinic acid","N-Acetylglutamic acid","2,4-Dichloro-6-nitrophenol","N-Acetylvanilalanine","Sodium calcium edetate","3-(1H-1,2,3,4-tetrazol-5-yl)benzoic acid","His-Val","1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine","3'-Sialyllactose","3-(4,5-diphenyl-1H-imidazol-2-yl)phenol","Methylselenopyruvate","Sceptrin","9-[(3aR,4S,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-2-amino-3H-purin-6-one","N-Nervonoyl Arginine","(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[[(1S,6S,9S,10R,14R)-14-hydroxy-5,5,9,14-tetramethyl-6-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]oxy]oxane-3,4,5-triol","ITP","Tyrosylalanine","Cytochalasin D","2-(6-ethenyl-9-hydroxy-2,6,9a-trimethyl-4-oxo-3,5,5a,7,8,9-hexahydro-2H-pyrano[2,3-b]chromen-7-yl)-2-methylpropanoic acid","Cellobiono-1,5-lactone","3-Phenanthrenesulfonic acid","Mesotrione","7-Methoxy-4-(trifluoromethyl)coumarin","13-Hydroxy-17,19-dimethoxy-6-prop-1-en-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,17-pentaene-12,16-dione","Glyceric acid","Doronine","4-Hydroxybutyric Acid","9-Hydroxy-5b,8,11a-trimethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a,5a,8-tricarboxylic acid","3-Hydroxy-2-hydroxymethyl-6-methylpyridine","2-Aminoisobutyric acid","(1S,4aS,6S,7R,7aS)-6-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid","4-Nitro-1-naphthol","Homocitric acid","Cytolipin H","(25S)-Spirostane-3b,5b,6a-triol 3-[4''-rhamnosylglucoside]","N-Oleoyl glycine","2-Iodo-6-methoxyphenol","Uridine","N-(1-(Aminocarbonyl)-2,2-dimethylpropyl)-1-((4-fluorophenyl)methyl)-1H-indazole-3-carboxamide","3-Glucosyl-2,3',4,4',6-pentahydroxybenzophenone","2-[(4S,5S,5aS,9aS)-4-methoxy-6,6,9a-trimethyl-5-[(2E,4E,6E)-octa-2,4,6-trienoyl]oxy-1-oxo-4,5,5a,7,8,9-hexahydro-3H-benzo[e]isoindol-2-yl]pentanedioic acid","Lactate carbon","4-Hydroxyphenylacetaldehyde","(S)-(-)-4-Amino-2-hydroxybutyric acid","(3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylic acid","[4-acetyloxy-2,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl] (E)-3-(4-hydroxyphenyl)prop-2-enoate","Proline","1-(2-Phenylacetyl)-L-prolylglycine ethy ester","EXP 3174","4-Oxo-4-(phenylamino)-2-butenoic acid","n-Heptafluorobutyrylimidazole","Thr-Ala","Potassium permanganate","Glycoursodeoxycholic acid","7alpha,25-Dihydroxycholesterol","Cer(d18:0/22:6(5Z,8E,10Z,13Z,15E,19Z)-2OH(7S, 17S))","Prostaglandin F2alpha (PGF2a)","Melarsoprol","2,4-Dihydroxybutanoic acid","5-Hydroxy-2-hydroxymethylpyridine","Cobalt sulfate","Fumaric acid","5-(4-aminophenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione","Sucrose","Tricarballylic anhydride","2-Fluorobutyl 2-(8-azabicyclo[3.2.1]octan-1-yl)-5-iodobenzoate","2-Chloro-4,5-dimethoxybenzoic acid","N6-Acetyllysine","5-[(Aminooxy)sulfonyl]-2,4-dichlorobenzoic acid","(2S)-5-amino-2-[[(2R)-2-azaniumyl-4-methylpentanoyl]amino]-5-oxopentanoate","Secosterigmatocystin","2-[3-(Sulfooxy)phenyl]acetic acid","Edetate sodium","5,13,15-Trihydroxy-9-methyl-10-oxabicyclo[10.4.0]hexadeca-1(12),13,15-triene-3,11-dione","Chlorotrianisene","7-Methyl-1,4,5-naphthalenetriol 4-[xylosyl-(1->6)-glucoside]","Taurocholic acid","4-amino-2-methyl-5-diphosphomethylpyrimidine","Myricetin 7-(6''-galloylglucoside)","Androstane-3,17-Diol Glucuronide","Phenol, 4,4'-(3,3,5-trimethylcyclohexylidene)bis-","2,3-Dihydroxy-3-methylbutanoic acid","4'-Phosphopantothenate","6-(3-chloro-4-methylanilino)-1H-pyrimidine-2,4-dione","Obscurolide A1","(2R,3S,4S,5S,6R)-2-[[7-hydroxy-4-[(Z)-5-hydroxy-3-methylpent-3-enyl]-4a,8,8-trimethyl-3-methylidene-2,4,5,6,7,8a-hexahydro-1H-naphthalen-2-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol","N-Acetylglucosamine","17-Acetoxygrindelic acid","Suberic acid","TG(18:0/24:0/22:5(4Z,7Z,10Z,13Z,16Z))","7,8-Dihydroneopterin 2',3'-cyclic phosphate","p-Hydroxynefazodone","Acetic acid, 2-(methylamino)-2-oxo-","Hydroxyacetone","3,5-bis(difluoromethyl)-1H-pyrazole","Erlose","Gypenoside LXXV","D-Ribose 5-diphosphate","Idoxuridine","2,6-Dichloroindophenol","4-(Difluoromethoxy)-5-methoxy-2-nitrobenzoic acid","DG(15:0/18:1(12Z)-2OH(9,10)/0:0)","Creatinine","Termilin","2-[4-(4-Hydroxyphenoxy)-2-iodophenyl]-2,2-diiodoacetic acid","(2R,3S)-2-methylisocitrate","2-Hexadecyloctadec-9-enal","Formiminoglutamic acid","PE-NMe(14:1(9Z)/20:5(5Z,8Z,11Z,14Z,17Z))","Albacarcin M","Methanedisulfonic acid","Leu-Trp","TG(18:0/20:1(11Z)/20:1(11Z))","5-(3-Chlorophenyl)-5-methylimidazolidine-2,4-dione","2-[(3S,3aR,5R,7aS)-3a-acetyl-3-hydroxy-7a-methyl-2,3,4,5,6,7-hexahydro-1H-inden-5-yl]prop-2-enoic acid","(+)-Epigallocatechin","Bilirubin","Atpo","[(3R,4S,8S,8aS)-3-hydroxy-6,8a-dimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-hydroxybenzoate","Leu-Leu","Sulfoacetaldehyde","(2R,7R,8R,9R,10S,20S)-7,8,9,19-tetrahydroxy-6,17-bis(hydroxymethyl)-2,6,10,17-tetramethylhexacyclo[12.8.1.01,14.02,11.05,10.015,20]tricos-12-ene-20-carboxylic acid","DG(19:0/18:1(12Z)-2OH(9,10)/0:0)","Cholic acid/Muricholic acid, alanine-conjugated (1)","Uridine diphosphate glucose (UDP-glucose)","3beta,7alpha-Dihydroxy-5-cholestenoic acid","2-Methylglutamic acid","beta-Cryptoxanthin","71-hydroxychlorophyll a","PE(P-16:0/20:4(5Z,8Z,11Z,14Z))","2-Protocatechoylphloroglucinolcarboxylate","Carboplatin","rac 5-Carboxy Desisopropyl Tolterodine Methyl Ester","13,14-Dihydro-16,16-difluoroprostaglandin J2","2-Aminoadipic acid","Urolithin A 3,8-O-diglucuronide","Syndesine","N-(4-Aminobenzoyl)-L-glutamic acid","Cer(t18:0/6 keto-PGF1alpha)","Dodecanoic acid","3h-Felodipine","Diallat","Nitrilotriacetic Acid","3-chloro-6-nitro-9H-carbazole","Glycerophosphoethanolamine","Gly-Ser","Bifenox","Amylopectin","4-amino-N-(2-fluorophenyl)benzenesulfonamide","13(S)-HODE","Hyodeoxycholic acid","Hydroxyzine","eribaxaban","n2-(1-Carboxyethyl)-2'-deoxyguanosine","Bacteriohopanetetrol","N-Acetylalanine","1,2-Bis-O-sipoyl-beta-D-glucoside","3-[2-(2-Anilinoethenyl)-4,5-dihydro-1,3-thiazol-3-ium-3-yl]propane-1-sulfonate","4-Amino-N-1H-indazol-6-ylbenzenesulfonamide","5-[[(2R,3S,4S,5R,6S)-3,4-dihydroxy-6-[[5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-7-yl]oxy]-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methoxy]-3-hydroxy-3-methyl-5-oxopentanoic acid","Embelin","Magnesium oleate","(2-Amino-6-oxo-1H-purin-9-yl) dihydrogen phosphate","Ggstop","TG(15:0/22:2(13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","N7-Methylguanosine 5'-diphosphate","1-O-(15-carboxypentadecyl)-2-O-acetylglycero-3-phosphorylcholine","(1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid","5-Hydroxyvalproic acid","Kynurenic acid","(2Z)-2-(16-acetyloxy-6-hydroxy-4,8,10,14-tetramethyl-3,7-dioxo-2,4,5,6,9,11,12,13,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-ylidene)-6-methylhept-5-enoic acid","Succinate","Methionine","alpha-Ketoisovaleric acid","Hapten","Midafotel","Alphazurine","Brevilagin I","9-Oxooctadecanoic acid","Oleuropein","Flavogallol","Chlortetracycline","TG(22:4(7Z,10Z,13Z,16Z)/22:5(4Z,7Z,10Z,13Z,16Z)/22:4(7Z,10Z,13Z,16Z))","GDP-2-acetamido-2-deoxy-beta-mannuronate","Closantel","Carnosine","(+)-2-Amino-7-phosphonoheptanoic acid","Oxaliplatin","(3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide","4-(Naphthalen-2-ylamino)-4-oxobutanoic acid","Prednisolone 21-all-cis-farnesylate","N-Acetylglucosamine 6-Phosphate","N,1-diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide","2-[[1-(4-Nitrobenzoyl)pyrrolidine-2-carbonyl]amino]benzoic acid","Itaconyl-CoA","N-(4-(7-Diethylamino 4-methylcoumarin-3-yl)phenyl)iodoacetamide","Phenylacetylglycine","Galactinol","N1,N8-Diacetylspermidine","mupirocin W2","8,9-dihydroxy-5Z,11Z,14Z-eicosatrienoic acid","Daphylloside","methyl 2-(3,10-dihydroxy-5-methoxy-9-methyl-8,13-dioxatricyclo[7.3.1.02,7]trideca-2,4,6-triene-4-carbonyl)-3,5-dimethoxybenzoate","13,14-dihydro-16,16-difluoro Prostaglandin F2alpha","3-(Methylthio)propionic acid","(1R,4aR,4bS,6aS,9R,10R,10aS)-1-(carboxymethyl)-2-(2-carboxypropan-2-yl)-10-hydroxy-1,4a,4b,9,10-pentamethyl-3,4,5,6,7,8,9,10a,12,12a-decahydro-2H-chrysene-6a-carboxylic acid","Menadiol sodium diphosphate","dUTP","2-Chlorounguinol","Ribulose 5-phosphate","UDP-4-dehydro-6-deoxy-D-glucose","3-2-carboxyphenylcatechol","9,10-Dihydroergocornine methanesulfote","2-[[4-[4-(2,4-dimethoxy-6-methylbenzoyl)oxy-2-methyl-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybenzoyl]oxy-2-hydroxy-6-methylbenzoyl]amino]propanoic acid","3-(Benzoylamino)-2-Hydroxybenzoic Acid","beta-Muricholic acid","2-Hydroxy-3-(trifluoromethoxy)benzoic acid","Ile-Leu","3-Ureidopropionic acid","12-Methyltridecanoic acid","Zonampanel","Cer(d16:1/20:3(6,8,11)-OH(5))","3-(1-Methyl-2-Oxo-2,3-Dihydro-1h-Imidazo[4,5-B]pyridin-6-Yl)benzamide","8-Hydroxyluteolin 4'-methyl ether 8-glucoside-3'-sulfate","dTDP-4-oxo-2,3,6-trideoxy-D-glucose","Taurocyamine","Sanguisorbin E","5-(4-Methylpiperazin-1-yl)-5-oxopentanoic acid","(1S,3R)-3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate","Homoserine","gamma-Linolenic acid","5Z,8Z,11Z-Eicosatrienoic acid","alpha-Linolenic acid","(1-acetyloxy-3-hydroxy-6,8a-dimethyl-7-oxo-3-propan-2-yl-2,3a,4,8-tetrahydro-1H-azulen-4-yl) 4-hydroxybenzoate","7-(Anilino(phenyl)methyl)-2-methyl-8-quinolinol","Uridine 5'-monophosphate (UMP)","beta-Guanidinopropionic acid","Phe-Asp","N(2)-(2,4-Dichlorophenyl)-N-(7-{[(2,4-dichlorophenyl)amino]sulfonyl}-1-oxo-1,2-dihydronaphthalen-2-yl)glycinamide","De-O-methylsimmondsin","Gly-Ala","Glucono-1,5-lactone","7,12-Dioxolithocholic acid","Quercetin-3-o-xyloside","(2,3-Dihydroxybenzoyl)adenylate","Cer(d16:1/20:4(6E,8Z,11Z,14Z)+=O(5))","PYR-41","Costatone","2-(2,3-Dimethylphenyl)-7-methyl-1,2,4-triazaspiro[4.5]decane-3-thione","Trimethylselenonium","DG(14:1n5/0:0/18:4n3)","(2S)-2-[[(2R)-2-amino-3-hydroxypropanoyl]amino]butanedioic acid","Inosine","Benzenesulfonic Acid","1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine","Lumichrome","all-trans-3,4-didehydrolycopene","TG(i-20:0/8:0/10:0)","3-Oxo-2-[3-(trifluoromethyl)phenyl]isoindoline-4-carboxylic acid","TG(22:2(13Z,16Z)/O-18:0/22:2(13Z,16Z))","PI(18:0/20:4(5Z,8Z,11Z,14Z))","Cyfluthrin","2-hydroxy-1,3-dimethyl-9H-thioxanthen-9-one","Ala-Gly","N-Acetylmethionine","(2R)-3-(((2,3-Dihydroxypropoxy)(hydroxy)phosphoryl)oxy)-2-hydroxypropyl (Z)-heptadec-10-enoate","Ala-Glu","D-leucyl-L-arginine","6'-sialyllactose","3-Methylbut-2-enoic acid","Lys-Gln","4-oxo-4-[[(1R,5R,9R,10S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid","Ala-Gln","Chlorthal","2,4-difluoro-N-[2-(1H-indol-3-yl)ethyl]benzamide","(2E,6E,12E)-19-(2-Amino-2-oxoethyl)-9,11-dihydroxy-8-methoxy-10,12,14-trimethyl-15-oxohenicosa-2,6,12-trienedioic acid","Modithromycin","Sebacic acid","3-Cyanopropanoic acid","N5-acetyl-l-ornithine","CDP-Ethanolamine","Cicletanine","2-Hydroxystearic acid","1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoserine","4-Hydroxyvalerylcarnitine","DG(10:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4)/0:0)","4-tert-butyl-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide","Zoxazolamine","3-(Oxolan-2-yl)propanoic acid","trans-4-Hydroxycrotonic acid","2-deoxy-5-O-phosphono-D-erythro-pentose","(2-{2-[(3-Methoxyphenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid","1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid","Uridine 5'-diphosphate (UDP)","9-(4-hydroxy-3,5-dimethoxyphenyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one","Ferricrocin [M-H2+Fe]","N-(1-Deoxy-1-fructosyl)histidine","Dodecanedioic acid","1-Methylpseudouridine","2-[[3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[(5-hydroxy-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)oxy]oxane-3,4,5-triol","Deamino-beta-neuraminic acid","ADP-ribose","Glutamylleucylarginine","Nitarsone","Riboflavin cyclic-4',5'-phosphate","3,5-Dichloro-4-hydroxyphenylpyruvate","(1R,3R,5S,8S,13R,14S)-1-Hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione","Cyclosquamosin E","lamotrigine-2-N-glucuronide","Isocaproic acid","Val-Ser","Pantetheine","Orotic acid","2-(4-Methoxybenzenesulfonamido)acetic acid","Methylmalonic acid","4,7,10,13,16,19-Docosahexaenoic acid, (1R)-1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxooctadecyl)oxy]ethyl ester, (4Z,7Z,10Z,13Z,16Z,19Z)-","UNC0642","N,N'-Bis(4-fluorophenyl)thiourea","(9E)-5,6-Dihydroxy-4-methoxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-9,12-diene-2,18-dione","Isosilybin B","alpha-Rhamnopyranosyl-(1->2)-beta-galactopyranosyl-(1->2)-beta-glucuronopyranoside","DG(18:4n3/0:0/20:5n3)","TG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/O-18:0)","Oxypurinol","GDP-3,6-dideoxy-galactose","Chlomethoxyfen","Prolyl-Threonine","Azelaic acid","1,3-Cyclohexanedicarboxylic acid","4-Oxohexanoic acid","9-Oxo-11alpha,16R-dihydroxy-17-cyclobutyl-5Z,13E-dien-1-oic acid","Triphenyl phosphate","4-(1H-benzimidazol-2-yl)-1,2,5-oxadiazol-3-amine","5-Iodo-2'-deoxyuridine triphosphate","4-Ethoxybenzoic acid","Thiadiazolidinethione","7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one","4,4,4-Trifluorobutanoic acid","Glycodeoxycholic acid","Phe-Ala"],"additional_accession":[]},"is_claimable":false,"name":"Spirulina Prevents Hepatic Steatosis by Promoting Macrophage M2 Polarization via Gut Microbiota-Derived 2-Hydroxy-3-Methylbutyrate","description":"Background & Aims: Spirulina, a microalgae renowned for its nutrient density, shows promise in modulating glucose and lipid metabolism. However, its efficacy and underlying mechanisms against metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. We hypothesized that spirulina exerts its hepatoprotective effects by reshaping the gut microbiome and its associated metabolome. Methods: We conducted an 8-week pilot study in 23 patients with MASLD receiving spirulina supplements (1g TID), assessing changes in liver fat, enzymes, and metabolic parameters. To establish causality and elucidate mechanisms, we employed two distinct murine models of steatohepatitis: a Western diet model and a choline-deficient diet model. Interventions included spirulina gavage, antibiotic-induced microbiota depletion, fecal microbiota transplantation (FMT), and administration of the microbial metabolite 2-hydroxy-3-methylbutyrate (2H3MB). Multi-omics approaches (16S rRNA sequencing, metabolomics, single-cell RNA sequencing) and flow cytometry were utilized. Results: Spirulina supplementation significantly alleviated hepatic steatosis in both human subjects and murine models. This was accompanied by a restoration of gut microbial ecology, characterized by enriched beneficial genera (e.g., Clostridium leptum). Metabolomic profiling identified a marked increase in the gut microbiota-derived metabolite 2H3MB in the feces and liver. Critically, the protective effects of spirulina were abolished in microbiota-depleted mice and could not be transferred via FMT from spirulina-treated donors to naïve recipients, indicating a dependency on an intact and active microbiome. Direct administration of Clostridium leptum and 2H3MB was sufficient to recapitulate the anti-steatotic effects of spirulina in high-fat diet-fed mice. Mechanistically, single-cell RNA sequencing and flow cytometry revealed that 2H3MB reshaped the hepatic immune microenvironment by specifically promoting the M2 polarization of macrophages, which in turn ameliorated lipid accumulation. Conclusions: Our findings unveil a novel gut-liver axis pathway through which spirulina prevents hepatic steatosis. Spirulina enhances the production of 2H3MB by specific gut microbes Clostridium leptum, which then signals to the liver to drive an anti-inflammatory, pro-resolutive M2 macrophage polarization, ultimately mitigating lipid deposition. This work highlights gut microbial metabolites, particularly 2H3MB, as promising therapeutic targets for MASLD.","dates":{"publication":"2026-06-30","submission":"2026-06-30"},"accession":"MTBLS14903","cross_references":{}}