The resulting dataset underwent metabolite identification and preprocessing, after which data quality was assessed prior to further statistical analysis.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - alternating - hilic"],"chromatography_protocol":["Samples were separated using a Vanquish ultra-high performance liquid chromatography (UHPLC) system with a HILIC column. The column temperature was maintained at 25 °C, the flow rate was 0.3 mL/min, and the injection volume was 2 μL. The mobile phase consisted of solvent A (water containing 25 mM ammonium acetate and 25 mM ammonia solution) and solvent B (acetonitrile).
The gradient elution program was set as follows: 0–1.5 min, 98% B; 1.5–12 min, linear decrease from 98% to 2% B; 12–14 min, maintained at 2% B; 14–14.1 min, linear increase from 2% to 98% B; 14.1–17 min, maintained at 98% B. During the entire analysis, all samples were stored in an autosampler at 4 °C.
To minimize systematic signal fluctuations, all samples were analyzed continuously in a randomized order. Quality control (QC) samples were interspersed throughout the sample sequence to monitor instrument stability and ensure the reliability of analytical data.
"],"publication":["Ginsenoside Rg5, a novel activator of arginine metabolic reprogramming, protects against hypoxic neuronal injury and cognitive deficits via dual-targeting ASL and ODC1."],"submitter_affiliation":["Changchun University of Chinese Medicine"],"submitter_name":["Tingting Lou"],"organism_part":["Cell"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Samples were thawed slowly at 4 °C. An appropriate amount of each sample was mixed with pre-cooled methanol/acetonitrile/water solution (2:2:1, v/v), followed by vortex mixing and low-temperature sonication for 30 min. The mixture was stood at −20 °C for 10 min and then centrifuged at 14000 g for 20 min at 4 °C. The supernatant was collected and vacuum-dried.
Prior to mass spectrometry analysis, the dried residue was reconstituted in 100 μL acetonitrile aqueous solution (acetonitrile: water = 1:1, v/v), vortexed, and centrifuged at 14000 g for 15 min at 4 °C. The resulting supernatant was subjected to injection and analysis.
"],"organism":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS15037"],"author":["Tingting Lou. Changchun University of Chinese Medicine. ltt19900811@163.com."],"data_transformation_protocol":["Raw data were converted to .mzXML format via ProteoWizard, followed by peak alignment, retention time correction, and peak area integration using XCMS software.
"],"study_factor":["Group"],"submitter_email":["ltt19900811@163.com"],"sample_collection_protocol":["After seeding neural cells onto a culture plate, Rg5 pretreatment was performed and placed in an anaerobic environment.
"],"omics_type":["Metabolomics"],"study_design":["Metabolomics","hypoxia","MultiQuant","Thermo Scientific Q Exactive","untargeted analysis","Homo sapiens","cell","Ginsenoside Rg5","Vanquish LC"],"curator_keywords":["Metabolomics","hypoxia","MultiQuant","Thermo Scientific Q Exactive","untargeted analysis","Homo sapiens","Ginsenoside Rg5","cell","Vanquish LC"],"mass_spectrometry_protocol":["Samples were separated using a Vanquish LC ultra-high-performance liquid chromatography (UHPLC) system and then analyzed on a Q Exactive series mass spectrometer (Thermo Fisher Scientific) in both positive and negative electrospray ionization (ESI) modes.
The ESI source and MS parameters were set as follows: nebulizer gas (Gas1): 60; auxiliary heating gas (Gas2): 60; curtain gas (CUR): 30 psi; ion source temperature: 600 °C; ion spray voltage (ISVF): ±5500 V (for positive and negative modes). For MS1 full-scan acquisition, the mass-to-charge ratio range was 80–1200 Da, with a resolution of 60 000 and an accumulation time of 100 ms. For MS2, a segmented acquisition method was employed, with a scan range of 70–1200 Da, a resolution of 30 000, an accumulation time of 50 ms, and a dynamic exclusion time of 4 s.
"],"metabolite_name":["Phenylpyruvate","Corticosterone","Salmeterol","2(1h)-pyridinone","Milnacipran","Pyrocatechol","(2-{[3-hydroxy-2-tetradecanamidooctadec-4-en-1-yl phosphonato]oxy}ethyl)trimethylazanium","N-(octadecanoyl)sphing-4-enine-1-phosphocholine","1-o-octadecyl-sn-glyceryl-3-phosphorylcholine","Stearoyl ethanolamide","Pantothenol","Luteinizing hormone releasing hormone human","Adenosine 5'-triphosphate (atp)","Ketoleucine","Reserpine","Uridine 5'-triphosphate","Ile-thr","Iminodiacetic acid","(-)-quebrachitol","DL-proline","Valdecoxib","Glycolate","D-erythro-sphingosine-1-phosphate","Butyl 4-hydroxybenzoate","Capric acid","Cis-5-dodecenoic acid","Dihydroergotamine","Dl-cystathionine","Cyclohexylamine","Thymidine 5'-triphosphate","Pilocarpine","Tetrahydrofolate","Maltitol","Mevalonic acid","Arginine","21-hydroxyprogesterone","Secobarbital","D-ribose 1-phosphate","Glutathione","Hydroferulic acid","2-hydroxyisocaproic acid","Leucylleucine","4-hydroxy-3-methoxybenzyl alcohol","1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-n,n-dimethyl","L-carnitine","L-theanine","Fexofenadine",".beta.-naphthol","Temazepam","Pc 36:2","Oleamide","Methylergonovine","Kainic acid","Pantothenic acid","Etodolac","Nicotinic acid adenine dinucleotide (NAAD)","Ritonavir","Salicylaldehyde","1-oleoyl-2-stearoyl-sn-glycero-3-phosphocholine","Erucic acid","N-phenyl-2-naphthylamine","Saquinavir","Pipemidic acid","Azelastine","Aflatoxin b1","Vanillic acid","Succinic semialdehyde","Octaethylene glycol","1,2-dioleoyl-sn-glycero-3-phosphatidylcholine","Gln-pro","Benzyl alcohol","2-hydroxy-5-methoxybenzoic acid","L-threonate","Pyridine","Ala-Ala","Trans-traumatic acid","Digitoxin","1-(1z-octadecenyl)-2-(5z,8z,11z,14z-eicosatetraenoyl)-sn-glycero-3-phosphocholine","Cyprodinil","5-aminovaleric acid","Androsterone glucuronide","4-hydroxytamoxifen","Indole","Fusidic acid","D-ornithine","Isocitric acid","N,n-dimethylguanosine","Thiopental","Leupeptin","Cyclopentolate","Gdp-l-fucose","Adenosine","Estrone sulfate","N-propyl gallate","4-imidazoleacrylic acid","Pterostilbene","Benazepril","2-o-methyladenosine","DL-threonine","Melatonin","(-)-secoisolariciresinol","Trazodona","Isoproterenol","3,3-dimethylglutaric acid","6-hydroxymelatonin","D-glucono-1,5-lactone","4-piperidinecarboxamide","PC(16:0/16:0)","Lovatatin","Sphingosine","N-Acetyl-L-tyrosine","1-(1z-octadecenyl)-2-(4z,7z,10z,13z,16z,19z-docosahexaenoyl)-sn-glycero-3-phosphocholine","5'-phosphoribosyl-5-amino-4-imidazolecarboxamide (aicar)","Tricin methyl ether","Telmisartan","Psychosine","Lysine","Acetaminophen","Vildagliptin","Cabergoline","Phenylacetaldehyde","Hexobarbital","Clindamycin","Rosuvastatin","4-vinylphenol","Guanine","Meperidine","Suberoylanilide hydroxamic acid","4-(4-chlorophenyl)-4-hydroxypiperidine","NADH","S-methyl-5'-thioadenosine","Udp-n-acetylglucosamine","2-amino-1-phenylethanol","Cytidine 5'-monophosphate (CMP)","L-propionylcarnitine","Flunisolide","Myo-inositol","Atrazine desisopropyl","N-hydroxy-4-aminobiphenyl","1-methyladenosine","Xanthosine",".beta.-ecdysone","All-trans-4-hydroxyretinoic acid","Uridine 5'-monophosphate","Pitavastatin","Norcodeine","Tris(hydroxymethyl)aminomethane","NAD+","Atrazine","1,2-dioleoyl-sn-glycero-3-phospho-l-serine","N-acetylputrescine","Gln-his","Milrinone","2-hydroxybenzyl alcohol","Glycocholic acid","Phytic acid","Octadecanoic acid","Glycocholate","Ranolazine","Chenodeoxycholate","1-(1z-octadecenyl)-sn-glycero-3-phosphocholine","Bisphenol a","Indole-3-carboxaldehyde","Warfarin","Homoharringtonine","Adrenosterone","Oxyacanthine","DL-isoleucine","(3,4-dihydroxyphenyl)ethanol","Hydroquinone","O-acetyl-l-serine","Pro-Thr","Deoxythymidine 5'-phosphate (dTMP)","Guanidinopropionic acid","Guanidinoethyl sulfonate","Asiatic acid","Adenosine 5'-phosphosulfate","Taurochenodeoxycholate","D-proline","Pyrimethanil","Tiagabine","Testosterone enanthate","Lignoceric acid","Allopurinol riboside","Nabilone","His-Lys","His-ser","Lithocholylglycine","Thymine","Dobutamine","9-phenanthrol","Biocytin","Ofloxacin","Pamidronic acid","7-methylguanine","Trifluoroperazine","Trolox","Cyclic gmp","Sarcosine","Taurine","Zymosterol","Alanopine","Probucol","Naltrexone","(3r,5s,7r,9s,10s,12s,13r,14s,17r)-17-((2r)-7-hydroxy-6-methylheptan-2-yl)-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthrene-3,7,12-triol","Nelfinavir","Eprosartan","4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid","Agmatine","Isoliquiritigenin","Pyridoxal","Glycerol","Danazol","(-)-atropine","L-aspartic acid","5-L-Glutamyl-L-alanine","2-linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine","5.alpha.-androstan-17.beta.-ol-3-one sulfate","Loperamide","Topiramate","Undecanoic acid","Pyrrole-2-carboxylic acid","Fructose 1-phosphate","17alpha-hydroxyprogesterone","Quinaldic acid","1,2-dioleoyl-sn-glycero-3-phosphate","Orlistat","Triethanolamine","3-dehydroepiandrosterone sulfate","Geranylgeranyl pyrophosphate","Inosine 5'-monophosphate","N-acetylcadaverine",".beta.-cyano-l-alanine","1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine (SOPC)","Oleoyl-l-carnitine","Secoisolariciresinol","Olopatadine","1-stearoyl-2-docosahexaenoyl-sn-glycerol","Dopamine","Tamoxifen","Menaquinone 4","N-acetylaspartylglutamic acid","Butalbital",".alpha.-L-Glu-L-Asp","Pantothenate","Testosterone","Cyclohexanesulfamic acid","Psoralidin","Dl-a-hydroxybutyric acid","Dofetilide","Sarafloxacin","Uracil","Amprenavir","Eicosapentaenoic acid","Rhein","Quinapril","Azithromycin","2-hydroxyestradiol","Morphine","Diflunisal","Allyl isothiocyanate","Creatine","Cytidine 5'-monophosphate",".beta.-nicotinamide adenine dinucleotide(NAD)","Cytosine","Phenaceturic acid","Fenbendazole","Furostane base -2h + 1o, o-hex, o-pen-dhex","Cis-4,7,10,13,16,19-docosahexaenoic acid","Bisoprolol","Malate","Pregnenolone sulfate","Flusilazole","Asp-Arg","3-Phospho-D-glycerate","Montelukast sulfoxide","Adipic acid","Dl-Leu-dl-Val","Adenosine 5'-diphosphate","Chloroquine","Lomefloxacin","1-stearoyl-2-linoleoyl-sn-glycero-3-phospho-l-serine","Folate",".alpha.-d-galactose 1-phosphate","Apigenin 7-glucoside","1,2-dipalmitoleoyl-sn-glycero-3-phosphocholine","Disopyramide","Indinavir","N-acetyl-.beta.-d-mannosamine","Isoleucine","6-hydroxynicotinic acid","Thiouric acid","Cilastatin","Pyruvate","N2-Acetyl-L-ornithine","(3r,7r,9s,10s,12s,13r,14s,17r)-17-((2r)-6,7-dihydroxy-6-methylheptan-2-yl)-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthrene-3,7,12-triol","Cdp-ethanolamine","Pro-Trp","DL-Glutamic acid","Caproic acid","N-acetyl-d-lactosamine","Dihydroxyacetone phosphate","(+)-chlorpheniramine","Famciclovir","Palmitic acid","Chitobiose","Histidine","Lnt","15(s)-hydroxy-(5z,8z,11z,13e)-eicosatetraenoic acid","1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine","D-aspartic acid","Stearamide","Phosphoric acid","Nervonic acid","Propionic acid","7,8-dihydroneopterin","Phenylbutazone","Deoxyadenosine","Oseltamivir","Prazosin","Pergolide","Dillapiol","Epigallocatechin gallate","Gatifloxacin","N-Acetyl-D-Glucosamine 6-Phosphate","Glycerophosphocholine","3-methyladenine","Actinomycin d","Glimepiride","1-methylhydantoin","Amikacin","Tripropylamine","1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine","Dipivefrine","1-pentadecanoyl-sn-glycero-3-phosphocholine","2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (phip)","Medicagenic acid base + o-hex","Diethylcarbamazine","Hydroxyphenyllactic acid",".beta.-glycerophosphate","Salicylic acid","11alpha-hydroxyprogesterone","Xanthine","Ethyl laurate","Pramoxine","Ketamine","Choline","Asparagine","L-gulono-1,4-lactone","2',3'-dideoxycytidine","Fluorometholone","Acetylcysteine","D-arabinonic acid",".gamma.-glu-cys","Nandrolone","Maleic acid","Lsd","Sulfentrazone","N.epsilon.-acetyl-l-lysine","Crystal violet","Hydrocodone","Indoxyl sulfate","Docetaxel","L-pipecolic acid","2-arachidonoyl-1-stearoyl-sn-glycero-3-phosphoethanolamine","Phosphorylcholine","Indole-3-pyruvic acid","1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholine","Trp-Cys","Phenobarbital","Fluphenazine","Irbesartan","N-acetyl-d-glucosamine","Quinidine","Dihydroisoferulic acid","Dimethyl sulfoxide","Pyruvaldehyde","D-arabitol","Sarsasapogenin","Desferrioxamine","Sulfadiazine","His-Tyr","Vitamin k1","5,6,7,3',4'-pentamethoxyflavone","Leucine","2-hydroxymyristic acid","1-methyl-l-histidine","Dihydrothymine","1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 4,11-diethyl-4,9-dihydroxy-, (4s)-","Mifepristone","Curcumin","Piperidine","4-androstene-11.beta.,17.beta.-diol-3-one","Polydatin","Atazanavir","gamma-L-Glutamyl-L-phenylalanine","Prostaglandin f2.beta.","Ziprasidone","N-lauroyl-d-erythro-sphingosylphosphorylcholine","6-Hydroxydopamine","Arecaidine","Dethiobiotin","10-nitrooleic acid","Phosphocholine","Pyridoxal phosphate","Xylitol","Lactose","Albendazole","Docosatetraenoyl ethanolamide","Taurolithocholic acid sulfate","Vitamin c","Mandelonitrile","N-acetyl-l-phenylalanine","4-androsten-11.beta.-ol-3,17-dione","Norbuprenorphine","Gln-Ala","Isoeugenyl acetate","(-)-.alpha.-kainic acid","D-myo-inositol-1,3-diphosphate","Acenapthylene","Doxazosin","L-thyronine","Indican","Ethylenediaminetetraacetic acid","Oxyresveratrol","Prostaglandin f1.alpha.","Coniferyl alcohol","Deoxyinosine","Cortisol 21-sulfate","Diazepam","Mangostine","Prostaglandin i2","Flavone","Nicotinic acid adenine dinucleotide","Biotin","Paxilline","Rac-2-despiperidyl-2-aminorepaglinide","Phenol","DL-tryptophan","L-glutathione, reduced","Neomycin","Amlodipine","Mesaconic acid","Methylphenidate","D-galacturonic acid","Kukoamine a","Tetraethylene glycol monomethyl ether","L-methionine","Adenylosuccinate","Glycine","Ibuprofen .beta.-d-glucuronide","Gln-met","1-arachidoyl-2-hydroxy-sn-glycero-3-phosphocholine","Glu-Arg","Oleic acid","N-acetyl-l-aspartic acid","Estriol","Propafenone","Cis,cis-muconic acid","Fructose 1,6-diphosphate","Decanoyl-l-carnitine","Pseudouridine","Iminostilbene","Pentazocine","Rotenone","1-palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine","L-homoarginine","6-phosphogluconic acid","Isoetharine","N-oleoylethanolamine","Betulinic acid","2'-o-methyladenosine","Mycophenolate mofetil","Ciprofloxacin","Soyasapogenol b + dhex + hex + hexa + malonyl","5-aminolevulinic acid","Propofol .beta.-d-glucuronide","2'-deoxyuridine 5'-monophosphate","Isovaleric acid","4-pyridoxic acid","Sinapyl alcohol","Bisdemethoxycurcumin","Prostaglandin d1","Citrate","Doxorubicin","Glyceryl tripalmitoleate","Ketoprofen","Glycyrrhizic acid","Octanoylcarnitine","1,2-ditetradecanoyl-sn-glycero-3-phosphocholine","G-guanidinobutyrate","Glyceric acid","DL-cysteine","N-acetyl-l-glutamate","Imatinib","Biliverdin","N8-acetylspermidine","Prostaglandin e3","Arachidonic acid (peroxide free)","L-norvaline","Palmitoyl sphingomyelin","Cis-11-eicosenoic acid","Hexose + c13h21o2","L-iditol","Uridine","2-oxooctanoic acid","Raloxifene","Glu-Phe","Enterodiol","Thiosulfuric acid","1-oleoyl-2-myristoyl-sn-glycero-3-phosphocholine","N6-methyl-l-lysine","Coproporphyrin i","Dulcitol","Isoxanthopterin","N-myristoylsphinganine","N-oleoyl-d-erythro-sphingosylphosphorylcholine","Beclomethasone","Losartan","Pyroquilon","15-ketoprostaglandin f2.alpha.","Thiamine","(.+/-.)-11-nor-.delta.9-tetrahydrocannabinol-9-carboxylic acid","Udp-d-glucose","L-homoserine",".gamma.-aminobutyric acid","Zafirlukast","Desmethylxanthohumol","Homogentisic acid","Nor-nitrogen mustard","3,4-dihydroxymandelic acid","Argininosuccinic acid","Hypotaurine","3,4-dihydroxy-l-phenylalanine","Levofloxacin","N-acetyl-l-methionine","Trihexyphenidyl","Trachelanthine","Gamma-glutamylvaline","N-glycolylneuraminic acid","Phlorizin","Diphenoxylate","Phloretin","(-)-riboflavin","3-hydroxymyristic acid","Phe-pro","Lopinavir","Norfloxacin","1-(1z-hexadecenyl)-sn-glycero-3-phosphocholine","Cinnavalininate","Amoxicillin","D-erythrose 4-phosphate","Perindopril","Trimethylamine n-oxide","Glutamic acid","4-phenylbutyric acid","Suberic acid","5,6-dihydroxyindole-2-carboxylic acid","Oxaprozin","Tetraethylene glycol","Propanoic acid","1-palmitoyl-2-oleoyl-sn-glycerol","Prunasin","2-propylglutaric acid","Alprenolol","Creatinine",".alpha.-ionone","Noscapine","Pyridoxine","1-aminocyclopropanecarboxylic acid","Diacetyl",".beta.-nicotinamide adenine dinucleotide phosphate","Trichlormethiazide","Cyproheptadine","D-turanose","Quercitrin","Valine","Stachydrine",".gamma.-undecalactone","Gibberellic acid","Arachidonoyl ethanolamide","Palmitoleoyl ethanolamide","Hexaethylene glycol","4-hydroxyphenethyl alcohol","D-2-phosphoglyceric acid","Astaxanthin","Guanosine diphosphate mannose","Nicotinamide ribotide","Tenofovir","4-aminophenol","1,2-diarachidonoyl-sn-glycero-3-phosphocholine","Betaine","Mitoxantrone","Jasmonic acid","Nortriptyline","Hesperetin","Uridine diphosphate glucose(UDP-D-Glucose)","Atovaquone","Kanamycin a","5-hydroxy-l-tryptophan","Cytidine","Enrofloxacin","3-methylxanthine","3-methylglutarylcarnitine","Glu-Asn","Atorvastatin",".gamma.-dodecalactone","O-desmethylastemizole","Morphine-3-glucuronide","Phosphoserine","N-acetylneuraminic acid","Ethylmorphine","Alfuzosin","Imazamethabenz-methyl","Alfentanyl","4-methylbenzyl alcohol","1-(3-pyridyl)-1-butanone-4-carboxylic acid","Caffeate","1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-n-methyl","Genipin","Uridine 5'-diphosphate","D-mannose 6-phosphate","Palmitamide","Phytolaccasaponin G","Sulindac","1-myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine","Strychnine","Ramiprilat","S-carboxymethyl-l-cysteine","Trioxsalen","Glutathione, oxidized","L-pyroglutamic acid","Phendimetrazine","Guanosine 5'-monophosphate","1-o-hexadecyl-2-o-(4z,7z,10z,13z,16z,19z-docosahexaenoyl)-sn-glyceryl-3-phosphorylcholine","Vincristine","Codeine","Quinate","Fluocinolone acetonide","19-hydroxyandrost-4-ene-3,17-dione","Butylated hydroxytoluene","2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine","Progesterone","Flecainide","S-allyl-l-cysteine","Naringenin","Allantoin","Dapsone","D-amygdalin","11beta-hydroxyprogesterone","Enalapril","Gamma-l-glutamyl-l-glutamic acid","Piperacillin","Atropine","Phosphoenolpyruvate","Adenosine 3'-monophosphate","Arctigenin","D-Sorbitol","Cytidine 5'-diphosphocholine","Lisinopril","Thiamine monophosphate","Succinate","Esmolol","5'-deoxyadenosine","Gly-Leu","Ng,ng-dimethyl-l-arginine","(2-aminoethoxy)[3-[hexadec-1-en-1-yloxy]-2-[icosa-5.8.11.14-tetraenoyloxy]propoxy]phosphinic acid","Pentamidine","Pentostatin","Linezolid","Cholesteryl sulfate","12-hydroxydodecanoic acid","Ricinoleic acid","Methoxsalen","Citrinin","L-citrulline","L-cystine","Papaverine","Pentadecanoic acid","Shikimate","DL-valine","6-ketoprostaglandin e1","Niacinamide","Cis-13-eicosenoic acid","Coenzyme q2","L-fucose-1-phosphate","L-threonine","Serotonin","Kojic acid","7.alpha.-hydroxy-4-cholesten-3-one","Leukotriene d4","Sanguinarine","4-hydroxyvalsartan","Guanosine 5'-monophosphate (GMP)","Estrone glucuronide","Flutamide","Fumarate","Leukotriene c4","(+)-catechin","(2-aminoethoxy)[2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-[octadeca-1.9-dien-1-yloxy]propoxy]phosphinic acid","Hexylamine","Indolelactic acid","Acetol","Taurocholate","3'-o-methylguanosine","Maltotetraose","Harmine","Streptomycin a","DL-asparagine","D-asparagine","Phytosphingosine","Pro-hyp","Formoterol","Propranolol","Isopentenyl pyrophosphate","Tyrosine","4-hydroxybenzaldehyde","4-hydroperoxy-2-nonenal","O-phosphotyrosine","Levamisole","Quinine","Coumarin","1-palmitoyl-sn-glycero-3-phosphocholine","Myristic acid","Sepiapterin","Hypoxanthine","Bergaptol","Phenyllactic acid","Linamarin","Acetyl-l-carnitine","Camp","16.alpha.-hydroxyestrone","L-Arginine","1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine","D-glutamine","Nevirapine","Androstan-3-ol-17-one 3-glucuronide","(S)-2-Hydroxyglutarate","Putrescine","3-hydroxyphenylacetic acid",".gamma.-hydroxybutyric acid","L-homocitrulline","1,2-dioleoyl-sn-glycerol","Shikonin","1,2-dihexadecanoyl-sn-glycero-3-phosphocholine","Phenylacetyl-l-glutamine","Nicotinate d-ribonucleotide","Tropine","Captopril","Adenine","Enoxacin","S-adenosyl-l-methionine","2-arachidonoylglycerol","Cortisone","1-Stearoyl-sn-glycerol 3-phosphocholine(LPC(18:0))","2,4-dichlorophenol","Enalaprilat","Inosine","Purine","Cocaine","DL-tyrosine","Ebastine","Quinacrine","Rac-n,n-didesmethyl-o-desmethylvenlafaxine glucuronide","Primaquine","7-ethyl-10-(4-n-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin","Gartanin","Cholic acid","Carnosol","Cytidine monophosphate n-acetylneuraminic acid","2'-Deoxyinosine 5'-monophosphate","Phloroglucinocarboxaldehyde","Caffeine","D-gluconate","O,o-dimethyl dithiophosphate","Nonanoic acid","Diltiazem","1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol)","Isobutyryl-l-carnitine","4-methyl-1h-pyrazole","Dihydrouracil","Ranitidine","Homocitrate","4,2'-dihydroxy-4',6'-dimethoxychalcone","Anacardic acid","1-myristoyl-sn-glycero-3-phosphocholine","Picolinic acid","S-adenosyl-l-homocysteine","Prephenate","Tridemorph","Glucose 1-phosphate","3-aminohexanoic acid","Perphenazine","4-hydroxycyclophosphamide","1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine","Nisoldipine","Dodecanedioic acid","S-Adenosylmethionine","L-palmitoylcarnitine","3-methylthiopropionate","Dibutyl phthalate","Labetalol","3-Butynoic acid","Sofalcone","D-2-aminobutyric acid","D-neopterin","5-hydroxyindoleacetate","Indole-3-acetamide","(+)-isocorydine","Tramadol","1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine","Valganciclovir","Ltc4-[d5]","5-methoxytryptophan","L-hydroxyarginine","N,n-dimethylformamide","Histamine","Methyltyrosinate","Eplerenone","Aminophenazone","Noroxymorphone","Protoporphyrin ix","D-glucarate","17.beta.-nandrolone decanoate","Mitragynine","N,n,n-trimethyllysine","Oxycodone","N-methyl-l-glutamic acid","3-methyl-l-histidine","Puerarin","16-hydroxyhexadecanoic acid","Taurodeoxycholic acid","Tridecanoic acid (Tridecylic acid)","Carboxyphosphamide","L-Carnosine","1-docosahexaenoyl-2-stearoyl-sn-glycero-3-phosphocholine","1-heptadecanoyl-sn-glycero-3-phosphocholine","Pyrrolidine","L-arabinose","Quinolinate","Epinephrine","DL-serine","Vindesine","Nicotinate","Terfenadine","D-erythronic acid .gamma.-lactone","Phosphocreatine","Acebutolol","Clozapine","Quercetin 3'-methyl ether","N-acetylhistidine","Tobramycin","Ondansetron"],"additional_accession":[]},"is_claimable":false,"name":"Ginsenoside Rg5 protects against hypoxic neuronal injury","description":"For metabolome analysis, major metabolic intermediates were analyzed with technical support from Applied Protein Technology Co., Ltd. (Shanghai, China) 17. Briefly, eight treated and untreated cell samples stored in liquid nitrogen were processed and separated by ultrahigh-performance liquid chromatography (UPLC) (1290 Infinity LC system; Agilent Technologies), followed by detection with a Triple Quad 6600 mass spectrometer (QTRAP/MS; AB SCIEX, Framingham, MA, USA).Energy metabolism-related metabolites were identified using Multiquant software.","dates":{"publication":"2026-07-14","submission":"2026-07-14"},"accession":"MTBLS15037","cross_references":{"HMDB":["HMDB0001431","HMDB0014568","HMDB0034221","HMDB0000244","HMDB0013692","HMDB0062770","HMDB0002780","HMDB0001944","HMDB0030184","HMDB0012097","HMDB0011460","HMDB0011352","HMDB0005784","HMDB0001231","HMDB0002180","HMDB0000694","HMDB0000645","HMDB0059883","HMDB0028815","HMDB0060245","HMDB0030180","HMDB0002520","HMDB0012322","HMDB0000221","HMDB0000902","HMDB0000112","HMDB0031683","HMDB0001049","HMDB0000710","HMDB0038311","HMDB0010407","HMDB0011262","HMDB0011253","HMDB0013122","HMDB0000992","HMDB0008443","HMDB0000564","HMDB0007865","HMDB0062690","HMDB0009837","HMDB0010564","HMDB0010565","HMDB0012390","HMDB0007218","HMDB0008002","HMDB0008923","HMDB0007866","HMDB0062737","HMDB0003072","HMDB0004031","HMDB0002059","HMDB0003876","HMDB0004240","HMDB0000335","HMDB0006294","HMDB0015694","HMDB0000374","HMDB0003955","HMDB0036458","HMDB0010390","HMDB0008727","HMDB0012108","HMDB0060510","HMDB0003331","HMDB0003646","HMDB0000001","HMDB0011500","HMDB0007869","HMDB0010379","HMDB0013409","HMDB0008097","HMDB0008102","HMDB0011149","HMDB0007982","HMDB0011503","HMDB0007973","HMDB0007102","HMDB0010382","HMDB0010381","HMDB0008057","HMDB0007179","HMDB0010384","HMDB0012380","HMDB0000564/HMDB0007878/HMDB0007879/HMDB0007880/HMDB0007882/HMDB0007884/HMDB0007886/HMDB0007887/HMDB0007897/HMDB0007898/HMDB0007911/HMDB0007912/HMDB0007913/HMDB0007914/HMDB0007936/HMDB0007937/HMDB0007938/HMDB0007939/HMDB0007940/HMDB0007958/HMDB0007959/HMDB0007960/HMDB0007961/HMDB0007964/HMDB0007966/HMDB0007967/HMDB0007981/HMDB0007982/HMDB0007983/HMDB0007984/HMDB0007985/HMDB0008002/HMDB0008003/HMDB0008004/HMDB0008005/HMDB0008028/HMDB0008029/HMDB0008065/HMDB0008066/HMDB0008067/HMDB0008068/HMDB0008069/HMDB0008070/HMDB0008071/HMDB0008091/HMDB0008092/HMDB0008119/HMDB0008120/HMDB0008121/HMDB0008126/HMDB0008129/HMDB0008145/HMDB0008147/HMDB0008182/HMDB0008183/HMDB0008186/HMDB0008191/HMDB0008192/HMDB0008230/HMDB0008231/HMDB0008232/HMDB0008233/HMDB0008269/HMDB0008270/HMDB0008271/HMDB0008272/HMDB0008274/HMDB0008304/HMDB0008306/HMDB0008308/HMDB0008309/HMDB0008312/HMDB0008317/HMDB0008322/HMDB0008323/HMDB0008324/HMDB0008375/HMDB0008377/HMDB0008379/HMDB0008400/HMDB0008401/HMDB0008402/HMDB0008409/HMDB0008410/HMDB0008413/HMDB0008414/HMDB0008415/HMDB0008416/HMDB0008426/HMDB0008427/HMDB0008428/HMDB0008429/HMDB0008431/HMDB0008444/HMDB0008507/HMDB0008508/HMDB0008509/HMDB0008510/HMDB0008514/HMDB0008515/HMDB0008516/HMDB0008522/HMDB0008536/HMDB0008537/HMDB0008538/HMDB0008539/HMDB0008540/HMDB0008541/HMDB0008542/HMDB0008543/HMDB0008606/HMDB0008607/HMDB0008608/HMDB0008609/HMDB0008610/HMDB0008611/HMDB0008612/HMDB0008614/HMDB0008615/HMDB0008655/HMDB0008657/HMDB0008658/HMDB0008659/HMDB0008660/HMDB0008661/HMDB0008662/HMDB0008663/HMDB0008664/HMDB0008665/HMDB0008668/HMDB0008669/HMDB0008670/HMDB0008671/HMDB0008672/HMDB0008673/HMDB0008674/HMDB0008676/HMDB0008681/HMDB0008682/HMDB0008683/HMDB0008684/HMDB0008686/HMDB0008688/HMDB0008690/HMDB0008691/HMDB0008692/HMDB0008697/HMDB0008698/HMDB0008699/HMDB0008700/HMDB0008702/HMDB0008703/HMDB0008704/HMDB0008706/HMDB0008707/HMDB0008730/HMDB0008731/HMDB0008732/HMDB0008733/HMDB0008734/HMDB0008735/HMDB0008736/HMDB0008737/HMDB0008738/HMDB0008745/HMDB0008746/HMDB0008747/HMDB0008748/HMDB0008749/HMDB0008750/HMDB0008751/HMDB0008752/HMDB0008754/HMDB0008758/HMDB0008761/HMDB0008762/HMDB0008766/HMDB0008768/HMDB0008770/HMDB0008773/HMDB0008774/HMDB0008775/HMDB0008791/HMDB0008792/HMDB0008793/HMDB0008795/HMDB0008796/HMDB0008798/HMDB0008799/HMDB0008800","HMDB0013751","HMDB0015078","HMDB0004811","HMDB0000016","HMDB0041008","HMDB0001065","HMDB0009003","HMDB0004666","HMDB0006555","HMDB0001409","HMDB0001868","HMDB0059709","HMDB0000338","HMDB0000624","HMDB0002261","HMDB0008928","HMDB0007972","HMDB0004326","HMDB0013211","HMDB0060684","HMDB0002441","HMDB0000181","HMDB0001866","HMDB0029168","HMDB0032039","HMDB0001032","HMDB0061656","HMDB0000440","HMDB0011600","HMDB0000552","HMDB0000479","HMDB0001527","HMDB0001886","HMDB0006038","HMDB0062707","HMDB0062295","HMDB0060902","HMDB0030875","HMDB0001169","HMDB0006773","HMDB0060339","HMDB0060287","HMDB0032012","HMDB0011718","HMDB0013856","HMDB0004284","HMDB0060530","HMDB0013848","HMDB0000301","HMDB0015344","HMDB0041609","HMDB0000543","HMDB0000661","HMDB0000017","HMDB0004072","HMDB0036633","HMDB0001253","HMDB0006278","HMDB0001149","HMDB0003355","HMDB0001983","HMDB0000763","HMDB0000472","HMDB0006248","HMDB0002339","HMDB0001517","HMDB0001537","HMDB0004081","HMDB0002658","HMDB0004241","HMDB0001316","HMDB0002275","HMDB0001993","HMDB0060661","HMDB0000897","HMDB0059801","HMDB0015324","HMDB0001859","HMDB0006961","HMDB0001890","HMDB0000201","HMDB0015105","HMDB0000034","HMDB0000050","HMDB0003540","HMDB0001341","HMDB0001003","HMDB0000538","HMDB0000536","HMDB0000448","HMDB0006772","HMDB0006552","HMDB0001432","HMDB0000303","HMDB0033747","HMDB0014659","HMDB0014940","HMDB0014490","HMDB0000462","HMDB0000481","HMDB0006254","HMDB0005843","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