Base Peak Chromatogram of sample metabolites: After each sample was analyzed by UPLC-Q-Exactive Plus (LC-MS/MS), two raw mass spectrometry files were obtained (positive-ion mode and negative-ion mode), respectively.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - positive - hilic","Liquid Chromatography MS - negative - hilic"],"chromatography_protocol":["During the entire analysis process, the samples were placed in the 4-position autosampler. The analysis was performed using a SHIMADZU-LC30 ultra-high performance liquid chromatography (UHPLC) system equipped with an ACQUITY UPLC HSS T3 column (2.1 × 100 mm, 1.8 µm) (Waters, Milford, MA, USA). The injection volume was 6 µL, the column temperature was 40 °C, and the flow rate was 0.3 mL/min. The mobile phases consisted of A: 0.1% formic acid in water and B: 0.1% formic acid in acetonitrile. The gradient elution program was as follows: 0.01–1 min, 2% B; 1–5 min, B linearly increased from 2% to 48%; 5–7 min, B linearly increased from 48% to 80%; 7–11 min, B linearly increased from 80% to 100%; 11–13 min, B was maintained at 100%; 13–13.01 min, B linearly decreased from 100% to 2%; and 13.01–15 min, B was maintained at 2%.
"],"publication":["Hippophae rhamnoides-Derived Exosome-like Nanovesicles Alleviate Dexamethasone-Induced Sarcopenia by Remodeling Skeletal Muscle Lipid Metabolism."],"submitter_affiliation":["Peking University"],"submitter_name":["Duo Keai"],"organism_part":["Hippophae rhamnoides L."],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Plant-derived exosome-like nanovesicles were extracted from the fruits of sea buckthorn using the sucrose gradient centrifugation method, and their authenticity was verified by particle size analysis and electron microscopy.
"],"organism":["Hippophae rhamnoides"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS15070"],"author":["Qingrun Zhu. The Second Qilu Hospital of Shandong University. zhuqingrun@163.com.","Dachuan Wang. The Second Qilu Hospital of Shandong University. wangdachuan@medmail.com.cn."],"data_transformation_protocol":["The raw data were processed using MS-DIAL software for peak alignment, retention time correction, and peak area extraction. Metabolite structural identification was performed by precursor ion accurate mass matching and MS/MS spectral matching (mass tolerance < 0.01 Da) against a plant database.
"],"study_factor":["Group"],"submitter_email":["keaiduoduo998@126.com"],"sample_collection_protocol":["Sea buckthorn samples were collected from Cuona, Tibet. After the fruits were harvested, they were transported to the laboratory under low-temperature conditions for subsequent extraction.
"],"omics_type":["Metabolomics"],"study_design":["dexamethasone","Metabolomics","Hippophae rhamnoides","plant-derived exosome-like nanovesicles","Nexera X2 LC-30AD","untargeted analysis","Hippophae rhamnoides L.","PPAR signaling","Thermo Scientific Q Exactive Plus","sarcopenia"],"curator_keywords":["dexamethasone","Metabolomics","Hippophae rhamnoides","plant-derived exosome-like nanovesicles","Nexera X2 LC-30AD","untargeted analysis","Hippophae rhamnoides L.","PPAR signaling","Thermo Scientific Q Exactive Plus","sarcopenia"],"mass_spectrometry_protocol":["Each sample was analyzed using electrospray ionization (ESI) in both positive-ion (+) and negative-ion (−) modes. After separation by UPLC, mass spectrometric analysis was performed using a QE Plus mass spectrometer (Thermo Scientific) equipped with a HESI source for ionization. The ionization conditions were as follows: Spray Voltage: 3.8 kV (+) and 3.2 kV (−); Capillary Temperature: 320 °C; Sheath Gas: 30 (arbitrary units); Aux Gas: 5 (arbitrary units); Probe Heater Temp: 350 °C; S-Lens RF Level: 50.
The mass spectrometry acquisition settings were as follows:
The MS acquisition time was 15 min. The precursor ion scan range was 75–1050 m/z. The MS1 resolution was 70,000 at m/z 200, the AGC target was 3e6, and the maximum injection time (Maximum IT) for MS1 was 100 ms. Tandem MS (MS/MS) analysis was performed using the following method: after each full scan, MS2 spectra of the 10 most intense precursor ions were triggered for acquisition. The MS2 resolution was 17,500 at m/z 200, the AGC target was 1e5, the maximum injection time for MS2 was 50 ms, the MS2 activation type was HCD, the isolation window was 2 m/z, and the normalized collision energy (stepped) was set to 20, 30, and 40.
"],"metabolite_name":["Anandamide (20:l, n-9)","p-Mentha-1,3,5,8-tetraene","5-Ethyl-7,12-etheno-6,5-(iminoethano)-2,3,4,5-tetrahydro-1H-1-benzoazonine-2,13-dione","LysoPA(0:0/18:2(9Z,12Z))","13(S)-HOTrE","Butyric acid","13-Hydroxytridecanoic acid","(-)-trans-C75","Quercetin 3-(3R-glucosylrutinoside)","3-Phenyl-1H-isochromen-1-one","L-rhamnofuranose","Altretamine","8,9-epoxy-11-nor-7-driman-12-oic acid|nebularic acid B","5-Oxoavermectin ''1b'' aglycone","Pseudoanisatin","2-Benzylmalic acid","DEOXYSAPPANONE B TRIMETHYL ETHER","2-(4-methylpentanoyl)-1-hydroxy-8-methoxy-3-methylanthracene-9,10-dione|fistulaquinone A","Corypalline","2-Methyl-2-vinyloxirane","annuionone E","Nupharidine","Arenarine B","Tropolone","Amphetamine","Lophocerine","Tofacitinib","2'-Amino-2'-deoxyadenosine","5-{[(E)-3-(1H-imidazol-4-yl)-2-propenoyl]amino}pentanoic acid","Cimiracemoside D","Ser Tyr Arg","3-beta-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-oic acid","Indigo","phomactin L","Dimethylcurcumin","4-Hydroxybenzaldehyde","E-64d","Cyclohexylamine","Azaleatin 3-glucoside","7-ethoxy-3,4-dimethyl-2H-chromen-2-one","4-((9S)-3,5,14-trihydroxy-10-((E)-((1-hydroxybutan-2-yl)imino)methyl)-13-methylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one","alpha-Phocaecholic acid","Cladospolide E","Dicyclohexyl sulfosuccinate","3-[(1R,2S,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate","Acerogenin L","7-Hydroxyheptanoic acid","N-Phenethylacetamide","Xanthoplanine","putrebactin","2-methyleneglutaric acid","2alpha,7alpha-dihydroxydihydrovoaphylline","Caffeic acid","SM(d18:1/15:0)","Glutarate semialdehyde","Gamabufotalin","4-Methyl-5-nonanone","Oleamide","Aralia cerebroside","Lidocaine","Pantothenic acid","Eudesmin","Yohimbine","Glyceraldehyde","Malonic semialdehyde","Ardisiaquinone E","Flexibilene","Acetylglycine","Dimethisterone","Piperidione","1,3-dihydroxypropan-2-yl (9E,12E,15E)-octadeca-9,12,15-trienoate","13-Docosenamide","Phlegmariurine B","obtusadoid A","3-Epiaphidicolin","(E,E,E)-1,7-diphenyl-1,3,5-heptatriene|1,7-diphenylhepta-1,3,5-triene","1,4-Dideoxy-1,4-imino-D-arabinitol","Crustecdysone","trans-2-Octenoic acid","6-Methylcoumarin","alpha-Cyclogeraniol acetate","Benzyl 2-naphthyl ether","Hydrocortisone butyrate","Tabernine A","2-hept-1-enyl-2,3-dihydropyran-6-one","10-Hydroxy-11-methoxydracaenone","DDAO","Isorhamnetin","13,14-Dihydro-15-keto-PGE2","1-(9Z-hexadecenoyl)-glycero-3-phosphate","Rhamnose","(S)-2-Propylpiperidine","Bis(2-ethylhexyl) hydrogen phosphate","Cyclo(Tyr-Phe)","(2S)-2r,8c,17t-triisobutyl-5c,11c,14t-triisopropyl-7-methyl-1,4,10-trioxa-7,13,16-triaza-cyclooctadecane-3,6,9,12,15,18-hexaone|cyclo-(L-2-hydroxy-3-methyl-butyryl->N-methyl-L-leucyl->L-2-hydroxy-3-methyl-butyryl->D-valyl->D-leucyl->L-2-hydroxy-4-methyl-pentanoyl)|Pimaydolid|pimaydolide","Chenodeoxycholic acid","Pterosin E","4-methylenetetrahydrofuran-3-ol","2beta-Acetoxy-(3beta,7beta)-3-Hydddroxy-8-kempen-6-one","Antibiotic FD 211|FD-211","Indole","2',3'-Dihydroxyacetophenone","CHEMBL55033","Isorhamnetin-3-Galactoside-6''-Rhamnoside","4-Methylbenzaldehyde","Prostaglandin A1","Dibutylamine","Venlafaxine","Loliolide","N-Lauroylglycine","Batatasin III","evodiagenine","7-Hydroxy-10-dehydroxydeacetyldihydrobotrydial-1(10),5(9)-diene","Adenosine","Citronellyl acetate","PC(16:0/18:1(9Z))","N-Isobutyloctadeca-trans-2-trans-4-dienamide","2,4-Hexadien-1-ol","L-Alloisoleucine","Monooctyl phthalate","142-58-5","1',2'-Dihydroserpenone","(13S,14S)-epoxymaresin","Linoleic acid","Orthosphenic acid","beta-Yohimbine N-oxide","[6]-Gingerdione","Benzene","1-Methoxyphenazine","Alertenone","Stagonolide G","Cycloorbigenin 3-O-Beta-D-Xylopyranoside","Daidzin","Dodecanamide","3-Hydroxycapric acid","Fuscoatramide","4,7-dioxooctanoic acid","5Z-Dodecenoic acid","5-Methylcytosine","4,1-Benzoxazepine","Juniferinin","Traumatic acid","Tetradecanedioic acid","3,4-Dimethylpent-2-en-1-ol","6-(2-aminopyrimidin-4-yl)-4-butyl-7-hydroxy-8-methyl-2H-chromen-2-one","(S)-alpha-Phellandrene","Oleanolic acid","(E)-4-Hepten-2-one","3,8-di((E)-but-2-en-1-yl)-1-methyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione","3-Dehydrosphinganine","Sphingosine","Amidinomycin","Glycidyl oleate","n-Phenylformamide","Silux","Lythranidine","DMH-1","1H-Pyrrole-2-carboxaldehyde","Tiruchanduramine","Longithorone K","Terephthalic acid","Notoserolide D","N-[4-[(9S,13R)-16-hydroxy-7,9,13-trimethyl-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,18-dien-6-yl]-2-methylbutyl]acetamide","N-Undecanoylglycine","Oblongolide","12(S)-HEPE","Abietic acid","5,7-Dihydroxy-14-nor-8-marasmanone","4-(dimethylamino)butanoic acid","2-Isopropyl-3-oxosuccinate","Lomatin","Corynantheidine","NCGC00381387-02","[(1R)-1-(hydroxymethyl)-2-phosphonooxy-ethyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate","5,6-Dihydro-benzo[c]phenanthren-6-carbonsaeure|5,6-dihydro-benzo[c]phenanthrene-6-carboxylic acid","Pterosin H","LysoPE(0:0/16:0)","Succinic anhydride","SCHEMBL7700883","Cimicidanol-3-O-alpha-L-arabinoside","Gelsemin","Dibenzo[e,l]pyrene","Benzo[c]picene","Pterosin R","Callophycin A","Visamminol","Phenmetrazine","PGK2","PE(18:0/18:2(9Z,12Z))","2,2,6,7-Tetramethylbicyclo[4.3.0]nona-1(9),4-dien-8-one","(1S,4S)-4-Hydroxy-3-oxocyclohexane-1-carboxylate","Nitrobenzene","Neobonaspectin B","daphlongamine G|rel-(2aS,4aS,8S,9R,10aR,10bS,10cS)-2,2a,3,4,4a,5,7,8,9,10,10a,10b,11,12-tetradecahydro-2a-methoxy-8,10b-dimethyl-1H-9,10c-methanocyclopenta[1,8]azuleno[4,5-a]indolizine-1,13-dione","Norsecoswartzianin","Citric acid","Dipegine","Confertifoline","2,6-dimethoxy-4-prop-1-enylphenol","3-(2-Oxoazepan-1-yl)propanoic acid","ciguatoxin IJKLM cyclic acetal","D-Tetrahydropalmatine","4-hydroxy-4,6-dimethyl-1-tetralone|4-hydroxy-4,7-dimethyl-1-tetralone","Arachidoyl Ethanolamide","3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE","(-)-Epothilone E","Benzophenone","6beta-benzoyloxytropan-3alpha,7beta-diol|6beta-Benzoyloxytropane-3alpha,7beta-diol","Di-Ac-Neridienone B","Letestuianin C","N-Acetylimidazole","Debenzoyl-7-deoxo-7alpha-hydroxy-3-oxotashironin","ribalinine","Anhydrobelachinal","1-Octen-3-yl primeveroside","Methyl 4-carboxy-5-hydroxyphthalaldehydate","2,3-Dihydro-3-hydroxy-4-phenyl-5,9-dimethoxy-1H-phenalene","8-Chloroinosine","5-Hydroxymaltol","squalene","11-deoxy-PGE2","LysoPC(17:0/0:0)","Hydroquinone","heliopine|N2-(1'R-carboxyethyl)-L-glutamine|vitopine","cis-8,10-Diethyl-nor-lobelionol","Cucurbic acid","1,1-Diphenylurea","Hymatoxin A","Naltrindole","2-Methyl-1-pyrroline","Dioctylamine","Emoroidone","Dimethylaniline-N-oxide","Asiatic acid","2,3-O-Isopropylidene-alpha-D-Furanose-Riburonic acid","Genistein","Dendrobates Alkaloid 253","5,6-Dimethyl-2,3-pyrazinedicarbonitrile","2,6-Diphenylphenol","Diethyl phthalic acid","N-Hexadecanoylpyrrolidine","2-(5-Methoxy-5-methyltetrahydro-2-furanyl)-6,10-dimethyl-5,9-undecadien-2-ol","2-Oxo-delta3-4,5,5-trimethylcyclopentenylacetate","6-Methoxy-4-methylquinoline","Triptophenolide","Triethylhexanoin","Piperolein B","9-Acetoxy-p-mentha-1,3,5-triene-3-ol","Hupehemonoside","Propanamide, N-acetyl-","Farrerol","3-Oxopentanoic acid","Delgramine","Epiisopiloturine","(+/-)-lefetamine","3,3,5,5-tetramethylpiperidin-4-one","1H-Benzotriazole","2-Furancarboximidamide","PIPERIDINE-3,4,5-TRIOL","Prosopinine","Heptanoylcarnitine","(plusmn)12,13-DiHOME","Maybridge1_003784","p-Cresol sulfate","2,2,6,6-Tetramethyl-4-piperidone oxime","Quercetin 3-galactoside","Tridecanoylglycine","Trifluoroacetic acid","(E)-4,8-Dimethyl-1,3,7-nonatriene","Meconine","2,3-dihydro-6,6-dimethylbenzo[b][1,5]dioxocin-4(6H)-one","ACMC-20lq4g","8-Amino-7-oxononanoic acid","PyroGlu-Glu","bohemine","Myristoleic acid","Trigonelline","1-Oxa-2-oxo-3-methylcycloheptane","6-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-methyl-1H-pyrazol-5-yl)-2,3-dihydrobenzo[b][1,4]dioxin-5-ol","2-Piperidinoethanol","2-Hydroxyterephthalic acid","CHLOROSUCCINIC ACID","1,2-Diphenylquinazolin-4(1H)-one","liparacid C","N-Nonanoylglycine","UNII-TX9B6RN1RM","Indan-1-ol","Ajmalicine","Matrine","Picfeltarraenin IA","2,10-Dibromo-3-choloro-7,8-epoxy-9-chamigranol","Acibenzolar","2,3,3-Trimethyl-6-methoxy-7-hydroxy-9-methyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dione","Corydalin","dihydrophloroglucinol","Keioside","11-Aminoundecanoic acid","2-Dehydrococcinelline","1,2,3,4,Tetrahydro-1,5,7-trimethylnapthalene","Metaphosphoric acid","2-Naphthalenesulfonic acid","2-Hydroxycampholonic acid","Undecanoic acid","Cryptotanshinone","LysoPA(18:2(9Z,12Z)/0:0)","Fraxidin","1,6,8-trihydroxy-1H,3H-cyclohepta[c]furan-5-one","4-Ethylaniline","Butyrolactone 3","Tetrahydroharman","Adrenoyl ethanolamide","2-hydroxypentadecanoic acid","Doxylamine","Ruscogenin","2-methylimidazo[1,5-b]isoquinoline-1,3,5(2H)-trione","2-(4-methoxyphenyl)ethyl acetate","Secoisolariciresinol","2,3-Dinitrophenol","4,4'-Dimethylangelicin","Phenylalanine","MF-EA 705beta","isoxazol-4-ol","n-pentanoylpentanamide","N-Methyldioctylamine","Cholesterol","Morpholine","O-Desmethylnaproxen","Pentaethylene glycol","2-Chloro-7-hydroxy-3-methoxy-1,9-dimethyldibenzofuran","Palmitoyl Serinol","2(3H)-Benzothiazolone","Parthenolide","Uracil","LysoPE(0:0/18:3(9Z,12Z,15Z))","(2S,3R,4R,5S,6S)-2-(Hydroxymethyl)-6-phenylmethoxyoxane-3,4,5-triol","2,6-Di-tert-butyl-4-hydroxymethylphenol","3-(4-Methoxyphenyl)-2-[2-methoxy-5-(2-propenyl)phenyl]propene","(1S,2R,5S,6R)-5,6-dihydroxy-2-methylcyclohex-3-enecarboxylic acid|massarigenin E","Asterelin A","CHEBI:79180","Dibenzo[b,pqr]perylene","Senecioic acid amide","Cytosine","Chidamide","Vindolinine","Dichotomine D","Dendocarbin K","LysoPA(18:1(9Z)/0:0)","10,16-Dihydroxy-hexadecanoate","Sumaresinolic acid","LysoPC(18:1/0:0)","Dihydromonacolin L acid","Methyl (5xi,19alpha)-1-Acetylaspidospermidine-3-Carboxylate","Oxalic acid","4-Methylbenzoate","Proansamitocin","3-Ac-3,11,17,21-Tetrahydroxypregnan-20-one,","(-)-Hydroxydihydrobovolide","1-butoxy-2-methyl-1-(2-methylpropoxy)propan-2-ol","Kobusone","2-tetradecanoyl-sn-glycero-3-phosphocholine","2,3-dinor-11beta-Prostaglandin F2alpha","5,9:6,9-Diepoxy-3-megastigmene","Glaucocalyxin A","icajine","Subamolide C","Ectocarpene","Harmaline","p-Octopamine","trans-2-pentenol","5-Ethenyl-1,6-dimethylphenanthrene-2-ol","Precyasterone","Arteannuin B","1-(4-oxo-4h-chromen-3-yl)-2,3,4,9-tetrahydro-1h-beta-carboline-3-carboxylic acid","Methyl 1-pentyl-1H-indole-3-carboxylic acid","(+)-(E,E)-3-Hydroxy-7-phenyl-4,6-heptadienic acid","Palmitoleic acid","4-({[(2R)-2-methyloctyl]oxy}carbonyl)benzoic acid|cotonoate A","I(-)","Kisantamine","Isoosajin","6-hydroxysalvinolone","3-Hydroxyphenylacetic acid","Vanilpyruvic acid","Bombykal","Dimethylethanolamine","4-Methyl-1H-indene","Myristoylglycine","1,2-dihydro-1,2-acenaphthylenediol","N-isopentyl-3-hydroxymethylpyrrolidine","Ethylbenzene","Paecilopeptin","16-Hydroxyhexadecanoic acid","1,3-CYCLOHEXADIENE","ACMC-20mubk","Isomurrayazoline","LysoPE(18:1(9Z)/0:0)","DTXSID40464329","Sinapaldehyde","4,5-Dicaffeoylquinic acid","3-Chlorodehydroleucodin","3alpha-Isobutyryloxytropane","Arnicolide C","8(14)-podocarpen-7,13-dion-18-oic acid","2-Naphthalenecarboxylic acid, 4,5-dimethoxy-","Necatorine","N-Vinyl-2-pyrrolidone","5alpha-Androstane-3beta,7alpha,17beta-triol","Cadabicilone","8-iso-PGF3a","Triamterene","N,N-Dimethyldodecylamine","Hydroxyanigorufone","N-(9-oxodecyl)acetamide","8-Methoxyflindersine","Glycerophosphocholine","2-hydroxynonanoic acid","2,3-Diphenyl-1H-inden-1-one","Corunnine","Salviolone","Gardenine","1,4-Bis(2-ethylhexyl) sulfosuccinate","Succinic acid semialdehyde","Benzanthrone","3-Hydroxyoctanoic acid","erymelanthine","Sempervirine","Salicylic acid","Flufenamic acid","N-Butanoyl-DL-homoserine lactone","Tocainide","3-Hydroxy-beta-ionone","3,5-Dimethoxytyramine","Decanoylcarnitine","Bacopaside V","Tricetin","Adalinine","5OH-HIP","ES-285","Choline","1-allyl-2-hydroxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one","2-(2-Hydroxyethoxy)ethyl benzoate","1H-Imidazole-4-carboxylic acid","Tromethamine","2-Phenylphenanthrene","Dibenzylamine","trans-p-Coumaric acid 4-glucoside","2S,3R,7S-trihydroxy-caryophyllan-[4,7]-6,8-oxide","Limonenecarboxylic acid","3-(2-methylbutyryloxy)tropan-6,7-diol","10-Methyl-11H-benzo[a]fluoren|10-methyl-11H-benzo[a]fluorene|10-Methyl-benzofluoren|10-Methylbenzofluoren|10-Methylchrysofluoren|8-Methyl-2,3-benzfluoren","Quercetin 3-isorhamninoside","Vitispirane","2-Deoxygalactopyranose","Cryptotanshinon;Tanshinone c","N-(4-Methylquinazolin-2-Yl)Guanidine","Tributyl Phosphate","12,13-EpOME","8-carboxyl-3-hydroxy-5-methoxy-2-dimethyl chroman|8-carboxyl-3-hydroxy-5-methoxy-2-dimethylchroman","Gliocladic acid","2-hydroxyiminohexanoic acid","Phosphorylcholine","4-Ethoxyphenylacetic acid","Undecanedioic acid","Dehydrodecodine","Norisotuboflavine","Oxymatrine","Wedelolactone","2,2,6,6-Tetramethylpiperidin-1-ol","Arborine","Dimethyl sulfoxide","Tetradecylamine","2-Linoleoyl Glycerol","1,8,15-triazacyclohenicosane-2,9,16-trione","Benzothiadiazine","Corynoxeine","Hetisine","Phthalic anhydride","isorhamnetin-3-O-rutinoside","6-methoxy-3-(2-hydroxy-1-ethoxyethyl)-beta-carboline","Leucine","TOTAROL-19-CARBOXYLIC ACID","L-3-Phenyllactic acid","Isoliensinine","p-Hydroxymethylphenylhydrazine","PE(16:0/18:1(9Z))","7-Deoxyloganetate","Epsilon-caprolactam","2-(1,3-Benzodioxol-5-yl)-7-hydroxy-3,5,6,8-tetramethoxy-4H-1-benzopyran-4-one","Ethoxyquin","homofluorodaturatine","Tetrahydrobungeanool","Rutin","Andrachamine","3,3-Dimethyl-2-oxabicyclo[2.2.2]octane-1-carboxylic acid","Pimprinaphine","n-benzoyl-d-alanine","2-Cyanoacetamide","1-[1-(1-Benzothiophen-2-yl)cyclohexyl]piperidine","Methyl alpha-D-galactopyranoside","rel-(7R,8S,1'R,3'R,4'R,5'S,6'R)-Delta8'-4',5',6'-trihydroxy-3,4,3'-trimethoxy-8.1',7.O.6'-neolignan","3beta-(3-hydroxy-2-methylbutyryloxy)tropane|astrimalvine B","LysoPC(18:3(9Z,12Z,15Z)/0:0)","Milbemycin A3 oxime","3-Butenoic acid","3,8-Dimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone","1-Hydroxybenzotriazole","(+)-Rauflorine","Glutamyltryptophan","Tetrahydroharmol","(10betaH,11xi)-11-Hydroxy-13-nor-6-eremophilen-8-one","6beta-Hydroxyasiatic acid","N5-benzoyl-DL-ornithine","Periplogenin","Topsentolide A1","dihydro-3-hydroxy-4,4-dimethyl- 2(3H)-Furanone","Penitricin D","Ophiopogonin C","5-Aminopentanamide","3,6-Anhydro-L-galactose-dimethylacetal|3,6-Anhydro-L-galaktose-dimethylacetal","Hibiscoquinone B","2-(1-Hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid","1-Methyl-3-phenethyl-1,2,3,4-tetrahydroquinazoline-2,4-dione","Kukoamine A","NSC692340","Beta-Febrifugine","Harman","3-Hydroxy-6,8-dimethoxy-7(11)-eremophilen-12,8-olide","Phenol","CHEBI:68869","Ethyl 2-amino-3-phenylpropanoate","Calystegine A7","Deoxycorticosterone","2-keto palmitic acid","Agglomerin C","2,3-dihydroxy-p-cumic acid","Alpha-Linolenoyl ethanolamide","Perforenone B","Pandangolide 1a","Genipic acid","Calystegine A6","Dicyclohexylamine","D-erythro-Sphingosine C-20","5-Nitro-2-(3-phenylpropylamino)benzoic acid","DINITROSOPENTAMETHYLENETETRAMINE","1-O-Methylisobractatin","alpha-Methylstyrene","DG(18:3n3/0:0/18:3n3)","8-azabicyclo[3.2.1]octan-3-yl 2-methylpropanoate","Glutaric acid","9,10,13-TriHOME","Anisopusine","icosasphinganine","Mepiprazole","3-(4-hydroxyphenyl)propyl Acetate","1-Piperidinecarboxaldehyde","6E-Geranylgeraniol-19-oic acid-1-O-methyl ether","(E)-Lyratic acid","Monoethyl carbonate","2-Methylglutaric acid","Nitrile-2-Furancarboxylic acid","Tetrahydro-2,5-furan-diacetic acid","Isolupalbigenin","1,2,4-trithiolane 4-oxide","LysoPE(16:1(9Z)/0:0)","Octadeca-9,12-dienal","Acpiox","Melophlin E","13-Carboxy-blumenol C","Butoctamide hydrogen succinate","1H-pyrrole-2-carbonitrile|2-cyano-pyrrol|2-cyanopyrrole|2-pyrrolecarbonitrile|2-pyrrolocarbonitrile|pyrrole 2-carbonitrile|pyrrole-2-carbonitrile","(2S,3S,4R,5R)-2,5-epoxy-3,4-dimethyl-8,9-methylenedioxy-10-methoxy-6,11-benzocycloheptan-1-one|gymnothedelignan A","Diethylphosphate","Tos-Arg-CH2Cl","gamma-Glutamylisoleucine","3,4-Dimethoxybenzaldehyde","D-gluco-3,4,5-Trihydroxy-2,6-dimethoxy-hexanal|O2,O6-dimethyl-D-glucose","DTXSID30773937","SCHEMBL16431775","4-Methoxycinnamic acid","ethyl 6,7-dimethoxy-4-oxo-2,3-dihydro-1H-naphthalene-2-carboxylate","Nuciferidine","Botryolide C","Benzyl 6-O-beta-D-apiofuranosyl-beta-D-glucoside","Deisovalerylblastmycin","1,3-Dibutyl-2-thiourea","Hexadecanedioic acid","PC(16:0/O-1:0)","Imatinib","Palmitoyl N-Isopropylamide","Palmitoleoylethanolamde","Cespihypotin M","Vulgarole","N~2~-[(7S)-7-(Acetylamino)-1,2,3-Trimethoxy-9-Oxo-5,6,7,9-Tetrahydrobenzo[A]Heptalen-10-Yl]-N-(1-Benzylpiperidin-4-Yl)-L-Isoleucinamide","10-Hydroxy-4,9-dimethyl-3,6-dodecadienedioic acid|3xi-Hydroxy-4xi,9-dimethyl-6E,9E-dodecadiendisaeure","CHEBI:87123","Memantine","Hexamidine","Pyrophosphate","1-dodecanoyl-glycero-3-phosphate","Ala Glu Arg","Calcium Gluceptate","Tulipalin B","3-Hydroxy-5-methylbenzaldehyde","11-nitro-1-undecene","(-)-Isobebeerine","Alangiobussinine","3,5,5-Trimethyl-2-cyclohexen-1-one","Halaminol C","3-Methylbutyraldehyde oxime","butyl 5-oxopyrrolidine-2-carboxylate","Piptamine(antibiotic)","LysoPI(16:0/0:0)","Testosterone sulfate","Isoindoline","2-Methylnaphthalene","Cytosporin C","Australin A","O-Arachidonoyl Ethanolamine","Emetine","DGMG(18:3)","HMS3352B01","2-Chloro-1,4-naphthoquinone","Dihydronortoxiferine I","Myricarborin","1-Pyrenemethanol","Roseocardin","2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol","12,13-Deoxyroridin E","Halisphingosine A","MG(0:0/16:1(9Z)/0:0)","12-Aminododecanoic acid","2,3-Dihydroxy-2'-carboxybiphenyl","Gly Arg Asp","TMS","2-amino-1,3,4-tetradecanetriol","Auraptene","Cantabrenolic acid","2'-Deoxyguanosine 5'-monophosphate","Melilotoside","2H-1-Benzopyran-6-carboxaldehyde, 3,4-dihydro-2,2-dimethyl-4-oxo-","Trachelanthine","Astragaloside IV","ZINC156664","CHEBI:70313","Cyclic GMP","Cortexolone","L-olivosyl-erythronolide B","10-Hydroxycamptothecin","(1R,4R)-p-Mentha-2,8-dien-1-ol","Sorbitan laurate","SCHEMBL4328945","clavulazol A","1,8-Dimethylnaphthalene","Triethylene glycol diglycidyl ether","13-HODE","Bungeiside C","Amoritin","4,8-dimethyl-1,5-dioxocane-2,6-dione","7-Hydroxychromone","Sclerin","4,4'-Dihydroxybenzophenone","Phenylbenzimidazolesulfonic acid","C20912; Tabtoxin biosynthesis intermediate 2","2,4,4'-trihydroxydihydrochalcone","Psicose","CHEBI:131749","PC(17:1(10Z)/0:0)","3-Methylcholanthrene","Citropone A","Suberic acid","Scabechinolol","2-Methoxyanofinic acid","acerogenin E","Tetraethylene glycol","Ginsenoside Rg5","(S)-[8]-Gingerol","EDDS","4-Nitrophenol","Hydroxyacetone","sewarine","Octadecanamide","2-Hydroxyisobutyrate","2-Ethylacrylic acid","2,3,4,9-Tetrahydro-6-methoxy-1H-pyrido(3,4-b)indol-1-one","(2S,3R)-2,3-Dihydroxy-5-oxohexanedioate","Cycloshermilamine D","2-Hydroxyheptanoic acid","8-dehydroxyl-14-dehydro-8,9,10-cyclopropyl-vilmorrianine D|vilmoraconitine A","3-Dimethylallyl-4-hydroxymandelic acid","Cladoacetal A","4-Vinylcyclohexene","(¡À)-Camphoric acid","Pimelic acid","Urea, N-(3-methyl-2-buten-1-yl)-","Adenosine 2',3'-cyclic phosphate","Diacetyl","Di-N-propylamine","Navenone B","Lichenin","4-HYDROXYBUT-2-ENAL","Ibogaline","Carboxy-ibuprofen","Litsealactone B","Hexaethylene glycol","Valeroidine","Quercetin 3-rutinoside 7-galactoside","Talaromycin A","Acepromazine","Palmitic amide","Bicyclo[4.2.0]octa-1,3,5-triene","Linoleoyl ethanolamide","LysoPC(0:0/16:0)","Racemosol","cis-(Homo)2-aconitate","Decamethylcyclopentasiloxane","Diethyl dicarbonate","(8R,9R,10S,13S,14S)-13-Methyl-1,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene","Hexadecasphingosine","Phenacetin","Mitoxantrone","Jasmonic acid","7-Methylquercetin-3-Galactoside-6''-Rhamnoside-3'''-Rhamnoside","Cyclopentanone","Norethindrone acetate","Neoline","13-Oxopodocarp-8(14)-en-18-oic acid","Ile-Leu-Val-Tyr","Me glcoside-beta-D-Pyranose-3-(Dimethylamino)-2,3,6-trideoxy-arabino-hexose|Me glycoside-alpha-D-Pyranose-3-(Dimethylamino)-2,3,6-trideoxy-arabino-hexose","5-Hydroxy-3,6,7,8,3',4',5'-heptamethoxyflavone","gerberlin C","SCHEMBL2216825","Carvyl acetate","Thalsimine","Capsiamide","alpha-Methylene-gamma-butyrolactone","deoxycymodienol","Daphniyunnine A","Cytochalasin II","Hexadecasphinganine","Ketorolac","Santene","Ensulizole","hysterolactone","6-hydroxy-2,3,4-trimethoxybenzaldehyde","Ginsenoside Rk1","N-(2-(((1S,9aR)-octahydro-1H-quinolizin-1-yl)methyl)-3-oxo-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazin-8-yl)propionamide","(2E,4E)-2,4-Hexadienoic acid","Sphinganine","Orsellinate","2-Hydroxyoctadecanoic acid","Tribufos","Simplexin B","(+)-Prosopinine","3,3-Difluoro-17-methyl-5alpha-androstan-17beta-ol","Dihydrostrobiline","Oleoylethanolamide","3,5-Dihydroxybenzyl alcohol","Bruceine H","Ala Arg Met","7-Hydroxy-2,3-dihydrobenzo[b]cyclopenta[d]pyran-4(1H)-one","2-(Methylamino)-3-oxo-3H-phenoxazine-8-carboxylic acid ethyl ester","13-Hydroxymyristic acid","Corylin","Swartzianin D","5-acetyloxy-3-methylpent-2-enoic acid","calyciphylline H","gamma-Terpinene","Farnesyl acetone","Lactic acid","Sulfate","Gallicynoic acid C","1,4-Cyclohexanedione","Isonicotinic acid","1-Chloro-3-nitrobenzene","LysoPE(0:0/18:0)","5,6-Dihydro-4-methoxy-2H-pyran-2-one","Embelin","Dapsone","3-Hydroxysuberic acid","2,3-DIMETHYL-1,4-HEXADIENE","D-Xylose","1,11-Undecanedicarboxylic acid","1,1,5-trimethyl-1,2-dihydronaphthalene","LysoPA(16:0/0:0)","His Lys Leu","Kynurenic acid","Kushenol F","2-Hydroxyethyl methacrylate","Palmitoylethanolamide","Carboxytolbutamide","3-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-7-ethoxy-2-methyl-4H-chromen-4-one","Pseudojervine","Gabapentin","Tectoridin","Ricinoleic acid","Celastrol","Citrinin","Idebenone","N-cis-11,14-eicosadienoyl ethanolamine","Delsoline","CHEMBL3314707","p-(1-Methyl-2,2-diphenylvinyl)anisole","Linoleamide","2-(2-Butoxyethoxy)ethanol","Phosphate","Monoisobutyl phthalic acid","Dihydromethysticin","Dibenzothiophene","2-methoxy-3,5,5-trimethylcyclohex-2-ene-1,4-dione","1,8-Diazacyclotetradecane-2,9-dione","Kaempferol","methyl (2beta,12beta,19alpha)-1-benzoylaspidospermidin-21-oate|N1-benzoyl-12-demethoxycylindrocarine","Roridin A","Di-Me ether-(E)-Alnusone","Laurencial","Decarboxy-Norlobaric Acid","DTXSID90711552","Lespeflorin G3","daphnipaxianine C","Monocrotalic acid","5-O-Methylxanthone V1","daphnezomine U","SCHEMBL15494054","Tumonoic acid D","alpha-5-C-(1,3-dihydroxybutyl)-hyacinthacine A1","11-Undecanolactone","Berbamine","A factor","3-(1H-indol-3-yl)quinoline","2-phenylphthalazin-1(2h)-one","Phytosphingosine","Mikaperiplocolide","1-Chloro-1,2-difluoroethylene","3,6-dihydronicotinate","3-(2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid","CHEBI:69006","Pentadecylamine","Fenpropimorph","LysoPC(18:2/0:0)","Buddledin A","Valerenic acid","6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole","Napelline N-oxide","Gitoxigenin","9,10-Dihydroxystearic acid","Curassavine","Abiraterone","nicotine N,N'-dioxide","1,5-Dioxo-7a-methyloctahydro-1H-indene-4-propanoic acid","Himbacine","Dimethylmalonic acid","Demethylzeylasteral","Lauramine oxide","N-(2-HYDROXYETHYL)DODECANAMIDE","imidazo[1,2-c]pyrimidin-5(1h)-one","Succinic acid","Hypoxanthine","Annuionone A","2,4-Dinitrophenol","7-Hydroxydodecanoic acid","Hippuric acid","alpha-Linolenic acid","Benzothiazole","Notoginsenoside R2","15-epi-lupulin B","Sulcatone","(6S,8S)-5,6,7,8-tetrahydro-1,3,6-trihydroxy-6-acetyl-8-methylnaphthalene-4-carboxylic acid|ficuselastic acid","1,1'-OXYBIS(4-ISOCYANATOBENZENE)","Tributylamine","cryptoquindoline","12-Noralliacolide","Gibberellin A15","Kaempferol 3-sophoroside 7-glucoside","SCHEMBL14163505","Songorine","N-Octyl-2-pyrrolidone","8-Deoxylactucin","Spiradine D","(+)-Neomethynolide","Cycluron","lycopladine H","2-methylbut-2-enamide","Pyrenophorol","(1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid","Triisopropanolamine","trans-8-hydroxy-3-methyldodec-cis-6-en-4-olide","aspergillomarasmin b","Adenine","octahydro-8-methyl-6-(2-methylpropylidene )-7,8-indolizinediol","Vismin","Paxiphylline E","LysoPC(16:0/0:0)","Isobutyric acid","Undecan-1,2,11-tricarbonsaeure|undecane-1,2,11-tricarboxylic acid","Oxysophocarpine","Desethylibophyllidine","2-Pyrrolidinone","Calligonine","breviocolline","SZDUUCCXZRJZRL-UHFFFAOYSA-","Histidinol","8-Chloro-2,7-dibenzofurandiol","5-Methoxy-3,4-dimethyl-5-pentyl-2(5H)-furanone","5-(Difluoromethoxy)-1H-benzo[d]imidazole-2-thiol","Cyclotriveratrylene","Theaspirane","N-Oleoyl Glycine","Cernuanone","Conhydrine","3-(methoxycarbonyl)-2,4-diphenylcyclobutanecarboxylic acid","cyclo(glycyl-L-prolylglycyl-L-prolylglycyl-L-prolylglycyl-L-prolyl)|cyclo(L-Pro-Gly)4|cyclo(L-ProGly)4|Cyclo(L-prolylglycyl)4|cyclo-(glycyl->-L-prolyl->-glycyl->-L-prolyl->-glycyl->-L-prolyl->-glycyl->-L-prolyl)","4-Hydroxybenzoic acid","trans-2-Hexenyl caproate (hexanoate)","Heptaethylene glycol","2,5-Dihydropyrimidine","3-Ethyl-2-hydroxy-4-methyl-2-cyclopenten-1-one","Sebacic acid","(2S)-methylbutanenitrile","Thioridazine","MG(18:1(9Z)/0:0/0:0)[rac]","Dinortrixagone","Penidienone","2,4-Dimethylbenzaldehyde","4-Methylumbelliferyl heptanoate","8-Methylquinoline","Acetoxymarsupellone","3-Phenoxybenzoic acid","Oridonin","2,2,6,6-Tetramethyl-4-piperidinone","2,6-Di-tert-butylpyridine","Asn Gln Gln","(5R,6E)-5-Hydroxy-1,7-Diphenyl-6-Hepten-3-One","Zeaxanthin","Hernandezine","2-Aminobenzimidazole","Pyroglutamic acid","5-Methylpyrogallol","1',8-Dihydroaplysinopsin","rupestine K","Chavicol","GTRI-02","Kadsutherin","CGS 12066B-parent","7-Hydroxypestalotin","CHEBI:75563","Dodecanedioic acid","triacetate lactone","Diosmetin 7-O-beta-D-glucopyranoside","3-[(1R,2S,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate; Epoxy-4S-H4HPP","7,9-Tetradecadiynoic acid","4'-methoxycyclopeptin","3-Methyl-4-(2,3-dihydroxyphenyl)-4-oxo-butanoic acid","(3E,5Z)-1,3,5-Heptatriene","Benzoguanamine","Crocusatin B","Fraxin","3-Hydroxyhexadecanoic acid","(-)-Epigallocatechin","Gingerol","Quinic acid","CHEMBL3289108","Dodecyl sulfate","Musk ambrette","N-Decanoylglycine","ACMC-20lyrb","4-methyl-N-quinolin-2-ylbenzenesulfonamide","Ruprechstyril","3-Methylpimelic acid","2-Methyl-4-isothiazolin-3-one","3'-O-beta-Glucopyranosyl plumbagic acid","Hormodirene","N-Lauroylsarcosine","Dibutyl phthalate","2'-Hydroxy-4,4',6'-trimethoxychalcone","Danofloxacin","DIHYDROMUNDULETONE","(Z)-2-Methyl-2-buttersaeure-(2-hydroperoxy-2-methyl-3-butenyl)ester","Diphenylamine","Isosorbide Dinitrate","Funebradiol|Funebral","3-Palmitoyl-sn-glycerol","Ursodeoxycholic acid","3-Hydroxysebacic acid","2-Methyl-3-oxopropanoic acid","Micrandrol E","Furmecyclox","Me ether,di-Me ester-Hydroxyphenylpropanedioic acid","Methylmalonic acid","Crocusatin G","LysoPE(18:2(9Z,12Z)/0:0)","Naproxen","MLS001182190","N-(2-Carboxymethyl)-morpholine","Malic acid","Nicotinamide N-oxide","Cotinine","Leucylalanine","SCHEMBL10213257","tsangibeilin A","1H-Imidazole-5-propanoic acid, alpha-methyl-","Chokol G","LysoPE(16:0/0:0)","xylacinic acid A","7-methyl-1,3,4,5,6,9-hexahydro-azecino[4,5,6-cd]indole-4-carboxylic acid|Clavicipitsaeure","Bortezomib","YPPCRKIUZHWKRW-UHFFFAOYSA-","7-Methyl-2,6-dioxabicyclo[3.3.1]nonane-3-one","Vitamin K1","N-(N-(3-Carboxyoxirane-2-carbonyl)leucyl)isoamylamine","Mellein","2,5-Epoxycyclopenta[5,6]naphth[1,2-d]azepin-9(1H)-one,hexadecahydro-5a,7a-dimethyl-, (2S,5R,5aS,5bS,7aR,10aS,10bS,12aR)-","3-Aminopicolinaldehyde","Orcinol","5-methoxy-6-methylbenzimidazole","Tetramethylene sulfoxide","13,14,15,16-tetranorlabd-7-en-(19,6beta),(12,17)-diolide|13,14,15,16-tetranorlabd-7-en-16,6beta:12,17-diolide|13,14,15,16-tetranorlabd-7-ene-19,6b:12,17-diolide","1,3-Dicyclohexylurea","6,7-Dimethoxy-1-phenyl-3,4-dihydroisoquinoline","5-Phenyl-1H-tetrazole","Ingenol-5,20-acetonide","6-Acetoxy-7-hydroxymyrcene-7-O-beta-D-glucopyranoside-2'-O-acetate","3,4-dihydro-6,8-dihydroxy-3,4,5-trimethyl-isocoumarin-7-carboxylic acid","Azelaic acid","Acutine","Chaetoglobosin A","Dodecamethylcyclohexasiloxane","cis-2-Carboxycyclohexyl-acetic acid","[(2R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate","Go 6976","Diethyltoluamide","Peucedanol","(R)-3-Hydroxydodecanoic acid","6,8-Dimethylquinoline","3'-AMP","10-methylundecanoic acid","(E)-10a-(2-(allyloxy)styryl)-10,10-dimethyl-3,4,10,10a-tetrahydropyrimido[1,2-a]indol-2-ol","16alpha-Hydroxyprogesterone","scalusamide B","1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-9-oxo-","15-Keto-13,14-dihydroprostaglandin A2","SM(d18:2(4E,14Z)/16:0)"],"additional_accession":[]},"is_claimable":false,"name":"Hippophae rhamnoides-Derived Exosome-like Nanovesicles Alleviate Dexamethasone-Induced Sarcopenia by Remodeling Skeletal Muscle Lipid Metabolism","description":"Skeletal muscle atrophy driven by glucocorticoid excess is a clinically relevant contributor to sarcopenia, yet safe and biologically integrated interventions remain limited. Here we report that extracellular exosome-like nanovesicles derived from Hippophae rhamnoides fruits (HR-ELNs) protect against dexamethasone-induced muscle wasting. HR-ELNs isolated by sucrose density gradient ultracentrifugation exhibited nanoscale vesicular morphology and carried a metabolite-rich cargo. In C2C12 cells, HR-ELNs were rapidly internalized and localized predominantly in the cytoplasm, where they counteracted dexamethasone-induced upregulation of Atrogin-1 and MuRF1, downregulation of MyoG, and reduction of MyHC-positive myotube area. In a dexamethasone-induced sarcopenia mouse model, intramuscular HR-ELN administration improved grip strength and treadmill endurance while attenuating the increase in body fat content. Multi-omics profiling of skeletal muscle revealed coordinated transcriptomic and proteomic remodeling after HR-ELN treatment, with convergent enrichment of lipid metabolism, fatty acid degradation, AMPK signaling and PPAR-related pathways. Histological analyses further supported reduced lipid deposition and altered PPAR immunoreactivity in gastrocnemius muscle. Together, these findings identify HR-ELNs as bioactive plant-derived nanovesicles that couple anti-atrophic and metabolic effects, and suggest a natural nanotherapeutic strategy for glucocorticoid-associated skeletal muscle dysfunction.","dates":{"publication":"2026-07-17","submission":"2026-07-17"},"accession":"MTBLS15070","cross_references":{"HMDB":["HMDB0002789","HMDB0015464","HMDB0259891","HMDB0035085","HMDB0036818","HMDB0003555","HMDB0005016","HMDB0011714","HMDB0030016","HMDB0000946","HMDB0000300","HMDB0000947","HMDB0000888","HMDB0259299","HMDB0240288","HMDB0000875","HMDB0014118","HMDB0252855","HMDB0013317","HMDB0029620","HMDB0259165","HMDB0259164","HMDB0259163","HMDB0001940","HMDB0341406","HMDB0000933","HMDB0039509","HMDB0304503","HMDB0001568","HMDB0341200","HMDB0015189","HMDB0014817","HMDB0036823","HMDB0258917","HMDB0029835","HMDB0059767","HMDB0094708","HMDB0258887","HMDB0000872","HMDB0002833","HMDB0002428","HMDB0030143","HMDB0001448","HMDB0035915","HMDB0032523","HMDB0001259","HMDB0000254","HMDB0000893","HMDB0000252","HMDB0000269","HMDB0029885","HMDB0240638","HMDB0240608","HMDB0258301","HMDB0249239","HMDB0013692","HMDB0000792","HMDB0038140","HMDB0001895","HMDB0003249","HMDB0257364","HMDB0034297","HMDB0000849","HMDB0003072","HMDB0037957","HMDB0030775","HMDB0039363","HMDB0000250","HMDB0000267","HMDB0038217","HMDB0036605","HMDB0002656","HMDB0004825","HMDB0029641","HMDB0030340","HMDB0000857","HMDB0004610","HMDB0256501","HMDB0001565","HMDB0001429","HMDB0000159","HMDB0000228","HMDB0014968","HMDB0256387","HMDB0256345","HMDB0256256","HMDB0243828","HMDB0008994","HMDB0008927","HMDB0011635","HMDB0007972","HMDB0000210","HMDB0002100","HMDB0013654","HMDB0013648","HMDB0003229","HMDB0012273","HMDB0002329","HMDB0029312","HMDB0002088","HMDB0002364","HMDB0002117","HMDB0013989","HMDB0034146","HMDB0013655","HMDB0255245","HMDB0013286","HMDB0255222","HMDB0035362","HMDB0255731","HMDB0241916","HMDB0013279","HMDB0255165","HMDB0013272","HMDB0041950","HMDB0302880","HMDB0002730","HMDB0032740","HMDB0242684","HMDB0039035","HMDB0013267","HMDB0255085","HMDB0001923","HMDB0243814","HMDB0255262","HMDB0247379","HMDB0061156","HMDB0013250","HMDB0002000","HMDB0254956","HMDB0031581","HMDB0254869","HMDB0002056","HMDB0031232","HMDB0015335","HMDB0011534","HMDB0000202","HMDB0246173","HMDB0341339","HMDB0254505","HMDB0015177","HMDB0301747","HMDB0033581","HMDB0032652","HMDB0011111","HMDB0000156","HMDB0061695","HMDB0011507","HMDB0011506","HMDB0011504","HMDB0011503","HMDB0011479","HMDB0011129","HMDB0011473","HMDB0010388","HMDB0010386","HMDB0002815","HMDB0012108","HMDB0010382","HMDB0240262","HMDB0007856","HMDB0007855","HMDB0007853","HMDB0007852","HMDB0304405","HMDB0302428","HMDB0012252","HMDB0000673","HMDB0062656","HMDB0014426","HMDB0302349","HMDB0028922","HMDB0000687","HMDB0000557","HMDB0000190","HMDB0000748","HMDB0000715","HMDB0030392","HMDB0036790","HMDB0014608","HMDB0037746","HMDB0037207","HMDB0005801","HMDB0032797","HMDB0015021","HMDB0002655","HMDB0060665","HMDB0030262","HMDB0304625","HMDB0033749","HMDB0253648","HMDB0001873","HMDB0000738","HMDB0240742","HMDB0059601","HMDB0014757","HMDB0253376","HMDB0059634","HMDB0000157","HMDB0034449","HMDB0006961","HMDB0002434","HMDB0253185","HMDB0000714","HMDB0061822","HMDB0242181","HMDB0000672","HMDB0013238","HMDB0061835","HMDB0035196","HMDB0030310","HMDB0001051","HMDB0000661","HMDB0012233","HMDB0028830","HMDB0252739","HMDB0252730","HMDB0252727","HMDB0031830","HMDB0005783","HMDB0303456","HMDB0003217","HMDB0036072","HMDB0252666","HMDB0005806","HMDB0011170","HMDB0252604","HMDB0005015","HMDB0252486","HMDB0252331","HMDB0037270","HMDB0059905","HMDB0039531","HMDB0062769","HMDB0251850","HMDB0251767","HMDB0000098","HMDB0250799","HMDB0001936","HMDB0000623","HMDB0251566","HMDB0032562","HMDB0037451","HMDB0251428","HMDB0302261","HMDB0002001","HMDB0032231","HMDB0248645","HMDB0001466","HMDB0002151","HMDB0251378","HMDB0030791","HMDB0303902","HMDB0250930","HMDB0012209","HMDB0094660","HMDB0032873","HMDB0251214","HMDB0251174","HMDB0033244","HMDB0251169","HMDB0251165","HMDB0003407","HMDB0056366","HMDB0000016","HMDB0250994","HMDB0000651","HMDB0014395","HMDB0250843","HMDB0033991","HMDB0000630","HMDB0341306","HMDB0031407","HMDB0031404","HMDB0001314","HMDB0029388","HMDB0035220","HMDB0030180","HMDB0001046","HMDB0250480","HMDB0250476","HMDB0250473","HMDB0000015","HMDB0034844","HMDB0041857","HMDB0000094","HMDB0000097","HMDB0000067","HMDB0250075","HMDB0000518","HMDB0034107","HMDB0002385","HMDB0038046","HMDB0041849","HMDB0060564","HMDB0040940","HMDB0036384","HMDB0031345","HMDB0001964","HMDB0037559","HMDB0000039","HMDB0014334","HMDB0249242","HMDB0242681","HMDB0303056","HMDB0032930","HMDB0032049","HMDB0001505","HMDB0248974","HMDB0030636","HMDB0000784","HMDB0037360","HMDB0034054","HMDB0248616","HMDB0030351","HMDB0248559","HMDB0032679","HMDB0014328","HMDB0014631","HMDB0059899","HMDB0246945","HMDB0013624","HMDB0001388","HMDB0248072","HMDB0013626","HMDB0011616","HMDB0000050","HMDB0000034","HMDB0000532","HMDB0015552","HMDB0247752","HMDB0302281","HMDB0004710","HMDB0247450","HMDB0002132","HMDB0301858","HMDB0247428","HMDB0240687","HMDB0340728","HMDB0032394","HMDB0245581","HMDB0036670","HMDB0000529","HMDB0255766","HMDB0002894","HMDB0032988","HMDB0012176","HMDB0247012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