MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/m_MTBLS15070_LC-MS_negative_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/m_MTBLS15070_LC-MS_positive_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/a_MTBLS15070_LC-MS_positive_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/s_MTBLS15070.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/a_MTBLS15070_LC-MS_negative_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/FILES/RAW_FILES/neg/HR-ELNs-2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/FILES/RAW_FILES/pos/HR-ELNs-3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/FILES/RAW_FILES/neg/HR-ELNs-4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/FILES/RAW_FILES/pos/HR-ELNs-1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/FILES/RAW_FILES/neg/HR-ELNs-1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/FILES/RAW_FILES/pos/HR-ELNs-4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/FILES/RAW_FILES/pos/HR-ELNs-2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070/FILES/RAW_FILES/neg/HR-ELNs-3.rawprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15070<p>Base Peak Chromatogram of sample metabolites: After each sample was analyzed by UPLC-Q-Exactive Plus (LC-MS/MS), two raw mass spectrometry files were obtained (positive-ion mode and negative-ion mode), respectively.</p>MetaboLightsPublicLiquid Chromatography MS - positive - hilicLiquid Chromatography MS - negative - hilic<p>During the entire analysis process, the samples were placed in the 4-position autosampler. The analysis was performed using a SHIMADZU-LC30 ultra-high performance liquid chromatography (UHPLC) system equipped with an ACQUITY UPLC HSS T3 column (2.1 × 100 mm, 1.8 µm) (Waters, Milford, MA, USA). The injection volume was 6 µL, the column temperature was 40 °C, and the flow rate was 0.3 mL/min. The mobile phases consisted of A: 0.1% formic acid in water and B: 0.1% formic acid in acetonitrile. The gradient elution program was as follows: 0.01–1 min, 2% B; 1–5 min, B linearly increased from 2% to 48%; 5–7 min, B linearly increased from 48% to 80%; 7–11 min, B linearly increased from 80% to 100%; 11–13 min, B was maintained at 100%; 13–13.01 min, B linearly decreased from 100% to 2%; and 13.01–15 min, B was maintained at 2%.</p>Hippophae rhamnoides-Derived Exosome-like Nanovesicles Alleviate Dexamethasone-Induced Sarcopenia by Remodeling Skeletal Muscle Lipid Metabolism.Peking UniversityDuo KeaiHippophae rhamnoides L.mass spectrometry assay<p>Plant-derived exosome-like nanovesicles were extracted from the fruits of sea buckthorn using the sucrose gradient centrifugation method, and their authenticity was verified by particle size analysis and electron microscopy.</p>Hippophae rhamnoideshttps://www.ebi.ac.uk/metabolights/MTBLS15070Qingrun Zhu. The Second Qilu Hospital of Shandong University. zhuqingrun@163.com.Dachuan Wang. The Second Qilu Hospital of Shandong University. wangdachuan@medmail.com.cn.<p>The raw data were processed using MS-DIAL software for peak alignment, retention time correction, and peak area extraction. Metabolite structural identification was performed by precursor ion accurate mass matching and MS/MS spectral matching (mass tolerance &lt; 0.01 Da) against a plant database.</p>Groupkeaiduoduo998@126.com<p>Sea buckthorn samples were collected from Cuona, Tibet. After the fruits were harvested, they were transported to the laboratory under low-temperature conditions for subsequent extraction.</p>MetabolomicsdexamethasoneMetabolomicsHippophae rhamnoidesplant-derived exosome-like nanovesiclesNexera X2 LC-30ADuntargeted analysisHippophae rhamnoides L.PPAR signalingThermo Scientific Q Exactive PlussarcopeniadexamethasoneMetabolomicsHippophae rhamnoidesplant-derived exosome-like nanovesiclesNexera X2 LC-30ADuntargeted analysisHippophae rhamnoides L.PPAR signalingThermo Scientific Q Exactive Plussarcopenia<p>Each sample was analyzed using electrospray ionization (ESI) in both positive-ion (+) and negative-ion (−) modes. After separation by UPLC, mass spectrometric analysis was performed using a QE Plus mass spectrometer (Thermo Scientific) equipped with a HESI source for ionization. The ionization conditions were as follows: Spray Voltage: 3.8 kV (+) and 3.2 kV (−); Capillary Temperature: 320 °C; Sheath Gas: 30 (arbitrary units); Aux Gas: 5 (arbitrary units); Probe Heater Temp: 350 °C; S-Lens RF Level: 50.</p><p><br></p><p>The mass spectrometry acquisition settings were as follows:</p><p>The MS acquisition time was 15 min. The precursor ion scan range was 75–1050 m/z. The MS1 resolution was 70,000 at m/z 200, the AGC target was 3e6, and the maximum injection time (Maximum IT) for MS1 was 100 ms. Tandem MS (MS/MS) analysis was performed using the following method: after each full scan, MS2 spectra of the 10 most intense precursor ions were triggered for acquisition. The MS2 resolution was 17,500 at m/z 200, the AGC target was 1e5, the maximum injection time for MS2 was 50 ms, the MS2 activation type was HCD, the isolation window was 2 m/z, and the normalized collision energy (stepped) was set to 20, 30, and 40.</p>Anandamide (20:l, n-9)p-Mentha-1,3,5,8-tetraene5-Ethyl-7,12-etheno-6,5-(iminoethano)-2,3,4,5-tetrahydro-1H-1-benzoazonine-2,13-dioneLysoPA(0:0/18:2(9Z,12Z))13(S)-HOTrEButyric acid13-Hydroxytridecanoic acid(-)-trans-C75Quercetin 3-(3R-glucosylrutinoside)3-Phenyl-1H-isochromen-1-oneL-rhamnofuranoseAltretamine8,9-epoxy-11-nor-7-driman-12-oic acid|nebularic acid B5-Oxoavermectin ''1b'' aglyconePseudoanisatin2-Benzylmalic acidDEOXYSAPPANONE B TRIMETHYL ETHER2-(4-methylpentanoyl)-1-hydroxy-8-methoxy-3-methylanthracene-9,10-dione|fistulaquinone ACorypalline2-Methyl-2-vinyloxiraneannuionone ENupharidineArenarine BTropoloneAmphetamineLophocerineTofacitinib2'-Amino-2'-deoxyadenosine5-{[(E)-3-(1H-imidazol-4-yl)-2-propenoyl]amino}pentanoic acidCimiracemoside DSer Tyr Arg3-beta-O-(E)-coumaroyl-D:C-friedooleana-7,9(11)-dien-29-oic acidIndigophomactin LDimethylcurcumin4-HydroxybenzaldehydeE-64dCyclohexylamineAzaleatin 3-glucoside7-ethoxy-3,4-dimethyl-2H-chromen-2-one4-((9S)-3,5,14-trihydroxy-10-((E)-((1-hydroxybutan-2-yl)imino)methyl)-13-methylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-onealpha-Phocaecholic acidCladospolide EDicyclohexyl sulfosuccinate3-[(1R,2S,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoateAcerogenin L7-Hydroxyheptanoic acidN-PhenethylacetamideXanthoplanineputrebactin2-methyleneglutaric acid2alpha,7alpha-dihydroxydihydrovoaphyllineCaffeic acidSM(d18:1/15:0)Glutarate semialdehydeGamabufotalin4-Methyl-5-nonanoneOleamideAralia cerebrosideLidocainePantothenic acidEudesminYohimbineGlyceraldehydeMalonic semialdehydeArdisiaquinone EFlexibileneAcetylglycineDimethisteronePiperidione1,3-dihydroxypropan-2-yl (9E,12E,15E)-octadeca-9,12,15-trienoate13-DocosenamidePhlegmariurine Bobtusadoid A3-Epiaphidicolin(E,E,E)-1,7-diphenyl-1,3,5-heptatriene|1,7-diphenylhepta-1,3,5-triene1,4-Dideoxy-1,4-imino-D-arabinitolCrustecdysonetrans-2-Octenoic acid6-Methylcoumarinalpha-Cyclogeraniol acetateBenzyl 2-naphthyl etherHydrocortisone butyrateTabernine A2-hept-1-enyl-2,3-dihydropyran-6-one10-Hydroxy-11-methoxydracaenoneDDAOIsorhamnetin13,14-Dihydro-15-keto-PGE21-(9Z-hexadecenoyl)-glycero-3-phosphateRhamnose(S)-2-PropylpiperidineBis(2-ethylhexyl) hydrogen phosphateCyclo(Tyr-Phe)(2S)-2r,8c,17t-triisobutyl-5c,11c,14t-triisopropyl-7-methyl-1,4,10-trioxa-7,13,16-triaza-cyclooctadecane-3,6,9,12,15,18-hexaone|cyclo-(L-2-hydroxy-3-methyl-butyryl->N-methyl-L-leucyl->L-2-hydroxy-3-methyl-butyryl->D-valyl->D-leucyl->L-2-hydroxy-4-methyl-pentanoyl)|Pimaydolid|pimaydolideChenodeoxycholic acidPterosin E4-methylenetetrahydrofuran-3-ol2beta-Acetoxy-(3beta,7beta)-3-Hydddroxy-8-kempen-6-oneAntibiotic FD 211|FD-211Indole2',3'-DihydroxyacetophenoneCHEMBL55033Isorhamnetin-3-Galactoside-6''-Rhamnoside4-MethylbenzaldehydeProstaglandin A1DibutylamineVenlafaxineLoliolideN-LauroylglycineBatatasin IIIevodiagenine7-Hydroxy-10-dehydroxydeacetyldihydrobotrydial-1(10),5(9)-dieneAdenosineCitronellyl acetatePC(16:0/18:1(9Z))N-Isobutyloctadeca-trans-2-trans-4-dienamide2,4-Hexadien-1-olL-AlloisoleucineMonooctyl phthalate142-58-51',2'-Dihydroserpenone(13S,14S)-epoxymaresinLinoleic acidOrthosphenic acidbeta-Yohimbine N-oxide[6]-GingerdioneBenzene1-MethoxyphenazineAlertenoneStagonolide GCycloorbigenin 3-O-Beta-D-XylopyranosideDaidzinDodecanamide3-Hydroxycapric acidFuscoatramide4,7-dioxooctanoic acid5Z-Dodecenoic acid5-Methylcytosine4,1-BenzoxazepineJuniferininTraumatic acidTetradecanedioic acid3,4-Dimethylpent-2-en-1-ol6-(2-aminopyrimidin-4-yl)-4-butyl-7-hydroxy-8-methyl-2H-chromen-2-one(S)-alpha-PhellandreneOleanolic acid(E)-4-Hepten-2-one3,8-di((E)-but-2-en-1-yl)-1-methyl-7,8-dihydro-1H-imidazo[2,1-f]purine-2,4(3H,6H)-dione3-DehydrosphinganineSphingosineAmidinomycinGlycidyl oleaten-PhenylformamideSiluxLythranidineDMH-11H-Pyrrole-2-carboxaldehydeTiruchanduramineLongithorone KTerephthalic acidNotoserolide DN-[4-[(9S,13R)-16-hydroxy-7,9,13-trimethyl-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,18-dien-6-yl]-2-methylbutyl]acetamideN-UndecanoylglycineOblongolide12(S)-HEPEAbietic acid5,7-Dihydroxy-14-nor-8-marasmanone4-(dimethylamino)butanoic acid2-Isopropyl-3-oxosuccinateLomatinCorynantheidineNCGC00381387-02[(1R)-1-(hydroxymethyl)-2-phosphonooxy-ethyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate5,6-Dihydro-benzo[c]phenanthren-6-carbonsaeure|5,6-dihydro-benzo[c]phenanthrene-6-carboxylic acidPterosin HLysoPE(0:0/16:0)Succinic anhydrideSCHEMBL7700883Cimicidanol-3-O-alpha-L-arabinosideGelseminDibenzo[e,l]pyreneBenzo[c]picenePterosin RCallophycin AVisamminolPhenmetrazinePGK2PE(18:0/18:2(9Z,12Z))2,2,6,7-Tetramethylbicyclo[4.3.0]nona-1(9),4-dien-8-one(1S,4S)-4-Hydroxy-3-oxocyclohexane-1-carboxylateNitrobenzeneNeobonaspectin Bdaphlongamine G|rel-(2aS,4aS,8S,9R,10aR,10bS,10cS)-2,2a,3,4,4a,5,7,8,9,10,10a,10b,11,12-tetradecahydro-2a-methoxy-8,10b-dimethyl-1H-9,10c-methanocyclopenta[1,8]azuleno[4,5-a]indolizine-1,13-dioneNorsecoswartzianinCitric acidDipegineConfertifoline2,6-dimethoxy-4-prop-1-enylphenol3-(2-Oxoazepan-1-yl)propanoic acidciguatoxin IJKLM cyclic acetalD-Tetrahydropalmatine4-hydroxy-4,6-dimethyl-1-tetralone|4-hydroxy-4,7-dimethyl-1-tetraloneArachidoyl Ethanolamide3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE(-)-Epothilone EBenzophenone6beta-benzoyloxytropan-3alpha,7beta-diol|6beta-Benzoyloxytropane-3alpha,7beta-diolDi-Ac-Neridienone BLetestuianin CN-AcetylimidazoleDebenzoyl-7-deoxo-7alpha-hydroxy-3-oxotashironinribalinineAnhydrobelachinal1-Octen-3-yl primeverosideMethyl 4-carboxy-5-hydroxyphthalaldehydate2,3-Dihydro-3-hydroxy-4-phenyl-5,9-dimethoxy-1H-phenalene8-Chloroinosine5-Hydroxymaltolsqualene11-deoxy-PGE2LysoPC(17:0/0:0)Hydroquinoneheliopine|N2-(1'R-carboxyethyl)-L-glutamine|vitopinecis-8,10-Diethyl-nor-lobelionolCucurbic acid1,1-DiphenylureaHymatoxin ANaltrindole2-Methyl-1-pyrrolineDioctylamineEmoroidoneDimethylaniline-N-oxideAsiatic acid2,3-O-Isopropylidene-alpha-D-Furanose-Riburonic acidGenisteinDendrobates Alkaloid 2535,6-Dimethyl-2,3-pyrazinedicarbonitrile2,6-DiphenylphenolDiethyl phthalic acidN-Hexadecanoylpyrrolidine2-(5-Methoxy-5-methyltetrahydro-2-furanyl)-6,10-dimethyl-5,9-undecadien-2-ol2-Oxo-delta3-4,5,5-trimethylcyclopentenylacetate6-Methoxy-4-methylquinolineTriptophenolideTriethylhexanoinPiperolein B9-Acetoxy-p-mentha-1,3,5-triene-3-olHupehemonosidePropanamide, N-acetyl-Farrerol3-Oxopentanoic acidDelgramineEpiisopiloturine(+/-)-lefetamine3,3,5,5-tetramethylpiperidin-4-one1H-Benzotriazole2-FurancarboximidamidePIPERIDINE-3,4,5-TRIOLProsopinineHeptanoylcarnitine(plusmn)12,13-DiHOMEMaybridge1_003784p-Cresol sulfate2,2,6,6-Tetramethyl-4-piperidone oximeQuercetin 3-galactosideTridecanoylglycineTrifluoroacetic acid(E)-4,8-Dimethyl-1,3,7-nonatrieneMeconine2,3-dihydro-6,6-dimethylbenzo[b][1,5]dioxocin-4(6H)-oneACMC-20lq4g8-Amino-7-oxononanoic acidPyroGlu-GlubohemineMyristoleic acidTrigonelline1-Oxa-2-oxo-3-methylcycloheptane6-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-methyl-1H-pyrazol-5-yl)-2,3-dihydrobenzo[b][1,4]dioxin-5-ol2-Piperidinoethanol2-Hydroxyterephthalic acidCHLOROSUCCINIC ACID1,2-Diphenylquinazolin-4(1H)-oneliparacid CN-NonanoylglycineUNII-TX9B6RN1RMIndan-1-olAjmalicineMatrinePicfeltarraenin IA2,10-Dibromo-3-choloro-7,8-epoxy-9-chamigranolAcibenzolar2,3,3-Trimethyl-6-methoxy-7-hydroxy-9-methyl-2,3-dihydronaphtho[1,2-b]furan-4,5-dioneCorydalindihydrophloroglucinolKeioside11-Aminoundecanoic acid2-Dehydrococcinelline1,2,3,4,Tetrahydro-1,5,7-trimethylnapthaleneMetaphosphoric acid2-Naphthalenesulfonic acid2-Hydroxycampholonic acidUndecanoic acidCryptotanshinoneLysoPA(18:2(9Z,12Z)/0:0)Fraxidin1,6,8-trihydroxy-1H,3H-cyclohepta[c]furan-5-one4-EthylanilineButyrolactone 3TetrahydroharmanAdrenoyl ethanolamide2-hydroxypentadecanoic acidDoxylamineRuscogenin2-methylimidazo[1,5-b]isoquinoline-1,3,5(2H)-trione2-(4-methoxyphenyl)ethyl acetateSecoisolariciresinol2,3-Dinitrophenol4,4'-DimethylangelicinPhenylalanineMF-EA 705betaisoxazol-4-oln-pentanoylpentanamideN-MethyldioctylamineCholesterolMorpholineO-DesmethylnaproxenPentaethylene glycol2-Chloro-7-hydroxy-3-methoxy-1,9-dimethyldibenzofuranPalmitoyl Serinol2(3H)-BenzothiazoloneParthenolideUracilLysoPE(0:0/18:3(9Z,12Z,15Z))(2S,3R,4R,5S,6S)-2-(Hydroxymethyl)-6-phenylmethoxyoxane-3,4,5-triol2,6-Di-tert-butyl-4-hydroxymethylphenol3-(4-Methoxyphenyl)-2-[2-methoxy-5-(2-propenyl)phenyl]propene(1S,2R,5S,6R)-5,6-dihydroxy-2-methylcyclohex-3-enecarboxylic acid|massarigenin EAsterelin ACHEBI:79180Dibenzo[b,pqr]peryleneSenecioic acid amideCytosineChidamideVindolinineDichotomine DDendocarbin KLysoPA(18:1(9Z)/0:0)10,16-Dihydroxy-hexadecanoateSumaresinolic acidLysoPC(18:1/0:0)Dihydromonacolin L acidMethyl (5xi,19alpha)-1-Acetylaspidospermidine-3-CarboxylateOxalic acid4-MethylbenzoateProansamitocin3-Ac-3,11,17,21-Tetrahydroxypregnan-20-one,(-)-Hydroxydihydrobovolide1-butoxy-2-methyl-1-(2-methylpropoxy)propan-2-olKobusone2-tetradecanoyl-sn-glycero-3-phosphocholine2,3-dinor-11beta-Prostaglandin F2alpha5,9:6,9-Diepoxy-3-megastigmeneGlaucocalyxin AicajineSubamolide CEctocarpeneHarmalinep-Octopaminetrans-2-pentenol5-Ethenyl-1,6-dimethylphenanthrene-2-olPrecyasteroneArteannuin B1-(4-oxo-4h-chromen-3-yl)-2,3,4,9-tetrahydro-1h-beta-carboline-3-carboxylic acidMethyl 1-pentyl-1H-indole-3-carboxylic acid(+)-(E,E)-3-Hydroxy-7-phenyl-4,6-heptadienic acidPalmitoleic acid4-({[(2R)-2-methyloctyl]oxy}carbonyl)benzoic acid|cotonoate AI(-)KisantamineIsoosajin6-hydroxysalvinolone3-Hydroxyphenylacetic acidVanilpyruvic acidBombykalDimethylethanolamine4-Methyl-1H-indeneMyristoylglycine1,2-dihydro-1,2-acenaphthylenediolN-isopentyl-3-hydroxymethylpyrrolidineEthylbenzenePaecilopeptin16-Hydroxyhexadecanoic acid1,3-CYCLOHEXADIENEACMC-20mubkIsomurrayazolineLysoPE(18:1(9Z)/0:0)DTXSID40464329Sinapaldehyde4,5-Dicaffeoylquinic acid3-Chlorodehydroleucodin3alpha-IsobutyryloxytropaneArnicolide C8(14)-podocarpen-7,13-dion-18-oic acid2-Naphthalenecarboxylic acid, 4,5-dimethoxy-NecatorineN-Vinyl-2-pyrrolidone5alpha-Androstane-3beta,7alpha,17beta-triolCadabicilone8-iso-PGF3aTriamtereneN,N-DimethyldodecylamineHydroxyanigorufoneN-(9-oxodecyl)acetamide8-MethoxyflindersineGlycerophosphocholine2-hydroxynonanoic acid2,3-Diphenyl-1H-inden-1-oneCorunnineSalvioloneGardenine1,4-Bis(2-ethylhexyl) sulfosuccinateSuccinic acid semialdehydeBenzanthrone3-Hydroxyoctanoic aciderymelanthineSempervirineSalicylic acidFlufenamic acidN-Butanoyl-DL-homoserine lactoneTocainide3-Hydroxy-beta-ionone3,5-DimethoxytyramineDecanoylcarnitineBacopaside VTricetinAdalinine5OH-HIPES-285Choline1-allyl-2-hydroxy-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one2-(2-Hydroxyethoxy)ethyl benzoate1H-Imidazole-4-carboxylic acidTromethamine2-PhenylphenanthreneDibenzylaminetrans-p-Coumaric acid 4-glucoside2S,3R,7S-trihydroxy-caryophyllan-[4,7]-6,8-oxideLimonenecarboxylic acid3-(2-methylbutyryloxy)tropan-6,7-diol10-Methyl-11H-benzo[a]fluoren|10-methyl-11H-benzo[a]fluorene|10-Methyl-benzo<a>fluoren|10-Methylbenzo<a>fluoren|10-Methylchrysofluoren|8-Methyl-2,3-benzfluorenQuercetin 3-isorhamninosideVitispirane2-DeoxygalactopyranoseCryptotanshinon;Tanshinone cN-(4-Methylquinazolin-2-Yl)GuanidineTributyl Phosphate12,13-EpOME8-carboxyl-3-hydroxy-5-methoxy-2-dimethyl chroman|8-carboxyl-3-hydroxy-5-methoxy-2-dimethylchromanGliocladic acid2-hydroxyiminohexanoic acidPhosphorylcholine4-Ethoxyphenylacetic acidUndecanedioic acidDehydrodecodineNorisotuboflavineOxymatrineWedelolactone2,2,6,6-Tetramethylpiperidin-1-olArborineDimethyl sulfoxideTetradecylamine2-Linoleoyl Glycerol1,8,15-triazacyclohenicosane-2,9,16-trioneBenzothiadiazineCorynoxeineHetisinePhthalic anhydrideisorhamnetin-3-O-rutinoside6-methoxy-3-(2-hydroxy-1-ethoxyethyl)-beta-carbolineLeucineTOTAROL-19-CARBOXYLIC ACIDL-3-Phenyllactic acidIsoliensininep-HydroxymethylphenylhydrazinePE(16:0/18:1(9Z))7-DeoxyloganetateEpsilon-caprolactam2-(1,3-Benzodioxol-5-yl)-7-hydroxy-3,5,6,8-tetramethoxy-4H-1-benzopyran-4-oneEthoxyquinhomofluorodaturatineTetrahydrobungeanoolRutinAndrachamine3,3-Dimethyl-2-oxabicyclo[2.2.2]octane-1-carboxylic acidPimprinaphinen-benzoyl-d-alanine2-Cyanoacetamide1-[1-(1-Benzothiophen-2-yl)cyclohexyl]piperidineMethyl alpha-D-galactopyranosiderel-(7R,8S,1'R,3'R,4'R,5'S,6'R)-Delta8'-4',5',6'-trihydroxy-3,4,3'-trimethoxy-8.1',7.O.6'-neolignan3beta-(3-hydroxy-2-methylbutyryloxy)tropane|astrimalvine BLysoPC(18:3(9Z,12Z,15Z)/0:0)Milbemycin A3 oxime3-Butenoic acid3,8-Dimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone1-Hydroxybenzotriazole(+)-RauflorineGlutamyltryptophanTetrahydroharmol(10betaH,11xi)-11-Hydroxy-13-nor-6-eremophilen-8-one6beta-Hydroxyasiatic acidN5-benzoyl-DL-ornithinePeriplogeninTopsentolide A1dihydro-3-hydroxy-4,4-dimethyl- 2(3H)-FuranonePenitricin DOphiopogonin C5-Aminopentanamide3,6-Anhydro-L-galactose-dimethylacetal|3,6-Anhydro-L-galaktose-dimethylacetalHibiscoquinone B2-(1-Hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid1-Methyl-3-phenethyl-1,2,3,4-tetrahydroquinazoline-2,4-dioneKukoamine ANSC692340Beta-FebrifugineHarman3-Hydroxy-6,8-dimethoxy-7(11)-eremophilen-12,8-olidePhenolCHEBI:68869Ethyl 2-amino-3-phenylpropanoateCalystegine A7Deoxycorticosterone2-keto palmitic acidAgglomerin C2,3-dihydroxy-p-cumic acidAlpha-Linolenoyl ethanolamidePerforenone BPandangolide 1aGenipic acidCalystegine A6DicyclohexylamineD-erythro-Sphingosine C-205-Nitro-2-(3-phenylpropylamino)benzoic acidDINITROSOPENTAMETHYLENETETRAMINE1-O-Methylisobractatinalpha-MethylstyreneDG(18:3n3/0:0/18:3n3)8-azabicyclo[3.2.1]octan-3-yl 2-methylpropanoateGlutaric acid9,10,13-TriHOMEAnisopusineicosasphinganineMepiprazole3-(4-hydroxyphenyl)propyl Acetate1-Piperidinecarboxaldehyde6E-Geranylgeraniol-19-oic acid-1-O-methyl ether(E)-Lyratic acidMonoethyl carbonate2-Methylglutaric acidNitrile-2-Furancarboxylic acidTetrahydro-2,5-furan-diacetic acidIsolupalbigenin1,2,4-trithiolane 4-oxideLysoPE(16:1(9Z)/0:0)Octadeca-9,12-dienalAcpioxMelophlin E13-Carboxy-blumenol CButoctamide hydrogen succinate1H-pyrrole-2-carbonitrile|2-cyano-pyrrol|2-cyanopyrrole|2-pyrrolecarbonitrile|2-pyrrolocarbonitrile|pyrrole 2-carbonitrile|pyrrole-2-carbonitrile(2S,3S,4R,5R)-2,5-epoxy-3,4-dimethyl-8,9-methylenedioxy-10-methoxy-6,11-benzocycloheptan-1-one|gymnothedelignan ADiethylphosphateTos-Arg-CH2Clgamma-Glutamylisoleucine3,4-DimethoxybenzaldehydeD-gluco-3,4,5-Trihydroxy-2,6-dimethoxy-hexanal|O2,O6-dimethyl-D-glucoseDTXSID30773937SCHEMBL164317754-Methoxycinnamic acidethyl 6,7-dimethoxy-4-oxo-2,3-dihydro-1H-naphthalene-2-carboxylateNuciferidineBotryolide CBenzyl 6-O-beta-D-apiofuranosyl-beta-D-glucosideDeisovalerylblastmycin1,3-Dibutyl-2-thioureaHexadecanedioic acidPC(16:0/O-1:0)ImatinibPalmitoyl N-IsopropylamidePalmitoleoylethanolamdeCespihypotin MVulgaroleN~2~-[(7S)-7-(Acetylamino)-1,2,3-Trimethoxy-9-Oxo-5,6,7,9-Tetrahydrobenzo[A]Heptalen-10-Yl]-N-(1-Benzylpiperidin-4-Yl)-L-Isoleucinamide10-Hydroxy-4,9-dimethyl-3,6-dodecadienedioic acid|3xi-Hydroxy-4xi,9-dimethyl-6E,9E-dodecadiendisaeureCHEBI:87123MemantineHexamidinePyrophosphate1-dodecanoyl-glycero-3-phosphateAla Glu ArgCalcium GluceptateTulipalin B3-Hydroxy-5-methylbenzaldehyde11-nitro-1-undecene(-)-IsobebeerineAlangiobussinine3,5,5-Trimethyl-2-cyclohexen-1-oneHalaminol C3-Methylbutyraldehyde oximebutyl 5-oxopyrrolidine-2-carboxylatePiptamine(antibiotic)LysoPI(16:0/0:0)Testosterone sulfateIsoindoline2-MethylnaphthaleneCytosporin CAustralin AO-Arachidonoyl EthanolamineEmetineDGMG(18:3)HMS3352B012-Chloro-1,4-naphthoquinoneDihydronortoxiferine IMyricarborin1-PyrenemethanolRoseocardin2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol12,13-Deoxyroridin EHalisphingosine AMG(0:0/16:1(9Z)/0:0)12-Aminododecanoic acid2,3-Dihydroxy-2'-carboxybiphenylGly Arg AspTMS2-amino-1,3,4-tetradecanetriolAurapteneCantabrenolic acid2'-Deoxyguanosine 5'-monophosphateMelilotoside2H-1-Benzopyran-6-carboxaldehyde, 3,4-dihydro-2,2-dimethyl-4-oxo-TrachelanthineAstragaloside IVZINC156664CHEBI:70313Cyclic GMPCortexoloneL-olivosyl-erythronolide B10-Hydroxycamptothecin(1R,4R)-p-Mentha-2,8-dien-1-olSorbitan laurateSCHEMBL4328945clavulazol A1,8-DimethylnaphthaleneTriethylene glycol diglycidyl ether13-HODEBungeiside CAmoritin4,8-dimethyl-1,5-dioxocane-2,6-dione7-HydroxychromoneSclerin4,4'-DihydroxybenzophenonePhenylbenzimidazolesulfonic acidC20912; Tabtoxin biosynthesis intermediate 22,4,4'-trihydroxydihydrochalconePsicoseCHEBI:131749PC(17:1(10Z)/0:0)3-MethylcholanthreneCitropone ASuberic acidScabechinolol2-Methoxyanofinic acidacerogenin ETetraethylene glycolGinsenoside Rg5(S)-[8]-GingerolEDDS4-NitrophenolHydroxyacetonesewarineOctadecanamide2-Hydroxyisobutyrate2-Ethylacrylic acid2,3,4,9-Tetrahydro-6-methoxy-1H-pyrido(3,4-b)indol-1-one(2S,3R)-2,3-Dihydroxy-5-oxohexanedioateCycloshermilamine D2-Hydroxyheptanoic acid8-dehydroxyl-14-dehydro-8,9,10-cyclopropyl-vilmorrianine D|vilmoraconitine A3-Dimethylallyl-4-hydroxymandelic acidCladoacetal A4-Vinylcyclohexene(¡À)-Camphoric acidPimelic acidUrea, N-(3-methyl-2-buten-1-yl)-Adenosine 2',3'-cyclic phosphateDiacetylDi-N-propylamineNavenone BLichenin4-HYDROXYBUT-2-ENALIbogalineCarboxy-ibuprofenLitsealactone BHexaethylene glycolValeroidineQuercetin 3-rutinoside 7-galactosideTalaromycin AAcepromazinePalmitic amideBicyclo[4.2.0]octa-1,3,5-trieneLinoleoyl ethanolamideLysoPC(0:0/16:0)Racemosolcis-(Homo)2-aconitateDecamethylcyclopentasiloxaneDiethyl dicarbonate(8R,9R,10S,13S,14S)-13-Methyl-1,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthreneHexadecasphingosinePhenacetinMitoxantroneJasmonic acid7-Methylquercetin-3-Galactoside-6''-Rhamnoside-3'''-RhamnosideCyclopentanoneNorethindrone acetateNeoline13-Oxopodocarp-8(14)-en-18-oic acidIle-Leu-Val-TyrMe glcoside-beta-D-Pyranose-3-(Dimethylamino)-2,3,6-trideoxy-arabino-hexose|Me glycoside-alpha-D-Pyranose-3-(Dimethylamino)-2,3,6-trideoxy-arabino-hexose5-Hydroxy-3,6,7,8,3',4',5'-heptamethoxyflavonegerberlin CSCHEMBL2216825Carvyl acetateThalsimineCapsiamidealpha-Methylene-gamma-butyrolactonedeoxycymodienolDaphniyunnine ACytochalasin IIHexadecasphinganineKetorolacSanteneEnsulizolehysterolactone6-hydroxy-2,3,4-trimethoxybenzaldehydeGinsenoside Rk1N-(2-(((1S,9aR)-octahydro-1H-quinolizin-1-yl)methyl)-3-oxo-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazin-8-yl)propionamide(2E,4E)-2,4-Hexadienoic acidSphinganineOrsellinate2-Hydroxyoctadecanoic acidTribufosSimplexin B(+)-Prosopinine3,3-Difluoro-17-methyl-5alpha-androstan-17beta-olDihydrostrobilineOleoylethanolamide3,5-Dihydroxybenzyl alcoholBruceine HAla Arg Met7-Hydroxy-2,3-dihydrobenzo[b]cyclopenta[d]pyran-4(1H)-one2-(Methylamino)-3-oxo-3H-phenoxazine-8-carboxylic acid ethyl ester13-Hydroxymyristic acidCorylinSwartzianin D5-acetyloxy-3-methylpent-2-enoic acidcalyciphylline Hgamma-TerpineneFarnesyl acetoneLactic acidSulfateGallicynoic acid C1,4-CyclohexanedioneIsonicotinic acid1-Chloro-3-nitrobenzeneLysoPE(0:0/18:0)5,6-Dihydro-4-methoxy-2H-pyran-2-oneEmbelinDapsone3-Hydroxysuberic acid2,3-DIMETHYL-1,4-HEXADIENED-Xylose1,11-Undecanedicarboxylic acid1,1,5-trimethyl-1,2-dihydronaphthaleneLysoPA(16:0/0:0)His Lys LeuKynurenic acidKushenol F2-Hydroxyethyl methacrylatePalmitoylethanolamideCarboxytolbutamide3-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-7-ethoxy-2-methyl-4H-chromen-4-onePseudojervineGabapentinTectoridinRicinoleic acidCelastrolCitrininIdebenoneN-cis-11,14-eicosadienoyl ethanolamineDelsolineCHEMBL3314707p-(1-Methyl-2,2-diphenylvinyl)anisoleLinoleamide2-(2-Butoxyethoxy)ethanolPhosphateMonoisobutyl phthalic acidDihydromethysticinDibenzothiophene2-methoxy-3,5,5-trimethylcyclohex-2-ene-1,4-dione1,8-Diazacyclotetradecane-2,9-dioneKaempferolmethyl (2beta,12beta,19alpha)-1-benzoylaspidospermidin-21-oate|N1-benzoyl-12-demethoxycylindrocarineRoridin ADi-Me ether-(E)-AlnusoneLaurencialDecarboxy-Norlobaric AcidDTXSID90711552Lespeflorin G3daphnipaxianine CMonocrotalic acid5-O-Methylxanthone V1daphnezomine USCHEMBL15494054Tumonoic acid Dalpha-5-C-(1,3-dihydroxybutyl)-hyacinthacine A111-UndecanolactoneBerbamineA factor3-(1H-indol-3-yl)quinoline2-phenylphthalazin-1(2h)-onePhytosphingosineMikaperiplocolide1-Chloro-1,2-difluoroethylene3,6-dihydronicotinate3-(2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acidCHEBI:69006PentadecylamineFenpropimorphLysoPC(18:2/0:0)Buddledin AValerenic acid6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indoleNapelline N-oxideGitoxigenin9,10-Dihydroxystearic acidCurassavineAbirateronenicotine N,N'-dioxide1,5-Dioxo-7a-methyloctahydro-1H-indene-4-propanoic acidHimbacineDimethylmalonic acidDemethylzeylasteralLauramine oxideN-(2-HYDROXYETHYL)DODECANAMIDEimidazo[1,2-c]pyrimidin-5(1h)-oneSuccinic acidHypoxanthineAnnuionone A2,4-Dinitrophenol7-Hydroxydodecanoic acidHippuric acidalpha-Linolenic acidBenzothiazoleNotoginsenoside R215-epi-lupulin BSulcatone(6S,8S)-5,6,7,8-tetrahydro-1,3,6-trihydroxy-6-acetyl-8-methylnaphthalene-4-carboxylic acid|ficuselastic acid1,1'-OXYBIS(4-ISOCYANATOBENZENE)Tributylaminecryptoquindoline12-NoralliacolideGibberellin A15Kaempferol 3-sophoroside 7-glucosideSCHEMBL14163505SongorineN-Octyl-2-pyrrolidone8-DeoxylactucinSpiradine D(+)-NeomethynolideCycluronlycopladine H2-methylbut-2-enamidePyrenophorol(1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acidTriisopropanolaminetrans-8-hydroxy-3-methyldodec-cis-6-en-4-olideaspergillomarasmin bAdenineoctahydro-8-methyl-6-(2-methylpropylidene )-7,8-indolizinediolVisminPaxiphylline ELysoPC(16:0/0:0)Isobutyric acidUndecan-1,2,11-tricarbonsaeure|undecane-1,2,11-tricarboxylic acidOxysophocarpineDesethylibophyllidine2-PyrrolidinoneCalligoninebreviocollineSZDUUCCXZRJZRL-UHFFFAOYSA-Histidinol8-Chloro-2,7-dibenzofurandiol5-Methoxy-3,4-dimethyl-5-pentyl-2(5H)-furanone5-(Difluoromethoxy)-1H-benzo[d]imidazole-2-thiolCyclotriveratryleneTheaspiraneN-Oleoyl GlycineCernuanoneConhydrine3-(methoxycarbonyl)-2,4-diphenylcyclobutanecarboxylic acidcyclo(glycyl-L-prolylglycyl-L-prolylglycyl-L-prolylglycyl-L-prolyl)|cyclo(L-Pro-Gly)4|cyclo(L-ProGly)4|Cyclo(L-prolylglycyl)4|cyclo-(glycyl->-L-prolyl->-glycyl->-L-prolyl->-glycyl->-L-prolyl->-glycyl->-L-prolyl)4-Hydroxybenzoic acidtrans-2-Hexenyl caproate (hexanoate)Heptaethylene glycol2,5-Dihydropyrimidine3-Ethyl-2-hydroxy-4-methyl-2-cyclopenten-1-oneSebacic acid(2S)-methylbutanenitrileThioridazineMG(18:1(9Z)/0:0/0:0)[rac]DinortrixagonePenidienone2,4-Dimethylbenzaldehyde4-Methylumbelliferyl heptanoate8-MethylquinolineAcetoxymarsupellone3-Phenoxybenzoic acidOridonin2,2,6,6-Tetramethyl-4-piperidinone2,6-Di-tert-butylpyridineAsn Gln Gln(5R,6E)-5-Hydroxy-1,7-Diphenyl-6-Hepten-3-OneZeaxanthinHernandezine2-AminobenzimidazolePyroglutamic acid5-Methylpyrogallol1',8-Dihydroaplysinopsinrupestine KChavicolGTRI-02KadsutherinCGS 12066B-parent7-HydroxypestalotinCHEBI:75563Dodecanedioic acidtriacetate lactoneDiosmetin 7-O-beta-D-glucopyranoside3-[(1R,2S,5R,6S)-5-Hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate; Epoxy-4S-H4HPP7,9-Tetradecadiynoic acid4'-methoxycyclopeptin3-Methyl-4-(2,3-dihydroxyphenyl)-4-oxo-butanoic acid(3E,5Z)-1,3,5-HeptatrieneBenzoguanamineCrocusatin BFraxin3-Hydroxyhexadecanoic acid(-)-EpigallocatechinGingerolQuinic acidCHEMBL3289108Dodecyl sulfateMusk ambretteN-DecanoylglycineACMC-20lyrb4-methyl-N-quinolin-2-ylbenzenesulfonamideRuprechstyril3-Methylpimelic acid2-Methyl-4-isothiazolin-3-one3'-O-beta-Glucopyranosyl plumbagic acidHormodireneN-LauroylsarcosineDibutyl phthalate2'-Hydroxy-4,4',6'-trimethoxychalconeDanofloxacinDIHYDROMUNDULETONE(Z)-2-Methyl-2-buttersaeure-(2-hydroperoxy-2-methyl-3-butenyl)esterDiphenylamineIsosorbide DinitrateFunebradiol|Funebral3-Palmitoyl-sn-glycerolUrsodeoxycholic acid3-Hydroxysebacic acid2-Methyl-3-oxopropanoic acidMicrandrol EFurmecycloxMe ether,di-Me ester-Hydroxyphenylpropanedioic acidMethylmalonic acidCrocusatin GLysoPE(18:2(9Z,12Z)/0:0)NaproxenMLS001182190N-(2-Carboxymethyl)-morpholineMalic acidNicotinamide N-oxideCotinineLeucylalanineSCHEMBL10213257tsangibeilin A1H-Imidazole-5-propanoic acid, alpha-methyl-Chokol GLysoPE(16:0/0:0)xylacinic acid A7-methyl-1,3,4,5,6,9-hexahydro-azecino[4,5,6-cd]indole-4-carboxylic acid|ClavicipitsaeureBortezomibYPPCRKIUZHWKRW-UHFFFAOYSA-7-Methyl-2,6-dioxabicyclo[3.3.1]nonane-3-oneVitamin K1N-(N-(3-Carboxyoxirane-2-carbonyl)leucyl)isoamylamineMellein2,5-Epoxycyclopenta[5,6]naphth[1,2-d]azepin-9(1H)-one,hexadecahydro-5a,7a-dimethyl-, (2S,5R,5aS,5bS,7aR,10aS,10bS,12aR)-3-AminopicolinaldehydeOrcinol5-methoxy-6-methylbenzimidazoleTetramethylene sulfoxide13,14,15,16-tetranorlabd-7-en-(19,6beta),(12,17)-diolide|13,14,15,16-tetranorlabd-7-en-16,6beta:12,17-diolide|13,14,15,16-tetranorlabd-7-ene-19,6b:12,17-diolide1,3-Dicyclohexylurea6,7-Dimethoxy-1-phenyl-3,4-dihydroisoquinoline5-Phenyl-1H-tetrazoleIngenol-5,20-acetonide6-Acetoxy-7-hydroxymyrcene-7-O-beta-D-glucopyranoside-2'-O-acetate3,4-dihydro-6,8-dihydroxy-3,4,5-trimethyl-isocoumarin-7-carboxylic acidAzelaic acidAcutineChaetoglobosin ADodecamethylcyclohexasiloxanecis-2-Carboxycyclohexyl-acetic acid[(2R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateGo 6976DiethyltoluamidePeucedanol(R)-3-Hydroxydodecanoic acid6,8-Dimethylquinoline3'-AMP10-methylundecanoic acid(E)-10a-(2-(allyloxy)styryl)-10,10-dimethyl-3,4,10,10a-tetrahydropyrimido[1,2-a]indol-2-ol16alpha-Hydroxyprogesteronescalusamide B1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-9-oxo-15-Keto-13,14-dihydroprostaglandin A2SM(d18:2(4E,14Z)/16:0)falseHippophae rhamnoides-Derived Exosome-like Nanovesicles Alleviate Dexamethasone-Induced Sarcopenia by Remodeling Skeletal Muscle Lipid MetabolismSkeletal muscle atrophy driven by glucocorticoid excess is a clinically relevant contributor to sarcopenia, yet safe and biologically integrated interventions remain limited. Here we report that extracellular exosome-like nanovesicles derived from Hippophae rhamnoides fruits (HR-ELNs) protect against dexamethasone-induced muscle wasting. HR-ELNs isolated by sucrose density gradient ultracentrifugation exhibited nanoscale vesicular morphology and carried a metabolite-rich cargo. In C2C12 cells, HR-ELNs were rapidly internalized and localized predominantly in the cytoplasm, where they counteracted dexamethasone-induced upregulation of Atrogin-1 and MuRF1, downregulation of MyoG, and reduction of MyHC-positive myotube area. In a dexamethasone-induced sarcopenia mouse model, intramuscular HR-ELN administration improved grip strength and treadmill endurance while attenuating the increase in body fat content. Multi-omics profiling of skeletal muscle revealed coordinated transcriptomic and proteomic remodeling after HR-ELN treatment, with convergent enrichment of lipid metabolism, fatty acid degradation, AMPK signaling and PPAR-related pathways. Histological analyses further supported reduced lipid deposition and altered PPAR immunoreactivity in gastrocnemius muscle. Together, these findings identify HR-ELNs as bioactive plant-derived nanovesicles that couple anti-atrophic and metabolic effects, and suggest a natural nanotherapeutic strategy for glucocorticoid-associated skeletal muscle dysfunction.2026-07-172026-07-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