MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/m_MTBLS15109_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/m_MTBLS15109_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/m_MTBLS15109_LC-MS_negative_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/m_MTBLS15109_LC-MS_positive_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/a_MTBLS15109_LC-MS_negative_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/a_MTBLS15109_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/a_MTBLS15109_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/s_MTBLS15109.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/a_MTBLS15109_LC-MS_positive_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_CON6_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_CON7_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_FDM14_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_CON6_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_FDM16_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_FDM11_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_CON7_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_CON7_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_CON8_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_FDM13_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_CON8_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_CON5_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_CON8_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_FDM6_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_FDM12_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_CON8_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_FDM6_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_FDM16_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_CON5_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_CON5_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_CON4_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_FDM6_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_FDM13_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_FDM6_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_CON4_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_CON5_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_CON9_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_FDM11_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_FDM12_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_CON4_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_FDM16_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_FDM13_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_CON4_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_CON9_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_FDM12_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_FDM14_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_FDM11_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_CON7_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_FDM13_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_CON9_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_CON6_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_FDM14_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_NEG_FDM11_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_NEG_FDM16_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_FDM12_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_CON6_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/Amide_POS_CON9_BL.mzXMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109/FILES/C18_POS_FDM14_BL.mzXMLprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15109<p>Raw data was processed with an in-house program. which was developed using R and based on XCMS, for feature detection, extraction, alignment, and integration. The R package and the BiotreeDB(V4.0) were applied in metabolite identification.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - hilicLiquid Chromatography MS - positive - reverse-phaseLiquid Chromatography MS - negative - hilic<p>For polar metabolites, LC-MS/MS analyses were performed using an UHPLC system (Vanquish, Thermo Fisher Scientific) with a Waters ACQUITY UPLC BEH Amide (2.1 mm × 50 mm, 1.7 μm) coupled to Orbitrap Exploris 120 mass spectrometer (Orbitrap MS, Thermo). The mobile phase consisted of 25 mmol/L ammonium acetate and 25 ammonia hydroxide in water (pH = 9.75) (A) and acetonitrile (B). The auto-sampler temperature was 4 ℃, and the injection volume was 2 μL.&nbsp;</p>Integrative Ophthalmology of Traditional Chinese and Western Medicine.Zefeng KangChina Academy of Chinese Medical Sciences Eye HospitalSerummass spectrometry assay<p>The animal tissue samples (25 mg±1 mg) were taken, mixed with beads and 500 μL of extraction solution (MeOH:ACN:H2O, 2:2:1 (v/v)). The extraction solution contain deuterated, internal standards. The mixed solution were vortexed for 30 s. Then the mixed samples were homogenized (35 Hz,4 min) and sonicated for 5 min in 4 ℃ water bath, the step repeat for three times. The samples were incubated for 1 h at -40 ℃ to precipitate proteins. Then the samples ware centrifuged at 12000 rpm (RCF=13800(×g),R= 8.6cm) for 15 min at 4 ℃. The supernatant was transferred to a fresh glass vial for analysis. The quality control (QC) sample was prepared by mixing an equal aliquot of the supernatant of samples.</p>Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS15109Zefeng Kang. China Academy of Chinese Medical Sciences Eye Hospital. kangzf7717@126.com.<p>The raw data were converted to the mzXML format using ProteoWizard and processed with an in-house program.</p>Genotypekangzf7717@126.com<p>Samples were extracted for metabolites by using the Starlid™workstation. The 50 ul sample was mixed with 200 ul of extraction solution(methanol:acetonitrile=1:1 (v/v), including internal standards), shaken at 750 rpm for 5 min and settled down for 5 min, then filtered through a protein precipitation plate and the filtrate was collected. The quality control (QC) sample was prepared by mixing an equal aliquot of the filtered liquid of samples.</p>MetabolomicsThermo Scientific Vanquish UHPLC SystemProteoWizard msconvertMetabolomicsMus musculusuntargeted analysisThermo Scientific Orbitrap Exploris 120myopiaSerumexperimental blankThermo Scientific Vanquish UHPLC SystemProteoWizard msconvertMetabolomicsMus musculusuntargeted analysisThermo Scientific Orbitrap Exploris 120myopiaSerumexperimental blank<p>The Orbitrap Exploris 120 mass spectrometer was used for its ability to acquire MS/MS spectra on information-dependent acquisition (IDA) mode in the control of the acquisition software (Xcalibur, Thermo). In this mode, the acquisition software continuously evaluates the full scan MS spectrum. The ESI source conditions were set as following: sheath gas flow rate as 50 Arb, Aux gas flow rate as 15 Arb, capillary temperature 320 ℃, full MS resolution as 60000, MS/MS resolution as 15000, collision energy: SNCE 20/30/40, spray voltage as 3.8 kV (positive) or -3.4 kV (negative), respectively.</p>N-Isopropylterephthalamic acidIsopropyl hexanoateVinylacetylglycine2,5-Di-tert-butylhydroquinoneTetranor 12-HETEIndican2'-O-Methyluridineall-trans-5,6-Epoxyretinoic acidPyrocatechol4-Hydroxy-5-(dihydroxyphenyl)-valeric acid-O-sulphatePteridinesFolic acid8-Oxononanoic acid1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoserineDeoxyinosineOctyl 2-furoateAllothreonine, L-2-Ketocaproic acid2-Carboxy-arabinitolIndole-3-methyl acetateN-AcetylvalineOleic acid, butyl esterKetoleucine(Z)-7-Hexadecenoic acidKukoamine AEthyl stearateCaplaminGPEtn(16:0p/22:6(4Z,7Z,10Z,13Z,16Z,19Z))(10e,15z)-9,12,13-Trihydroxyoctadeca-10,15-dienoic acidEthyl Myristate2,4-DimethylphenolNipecotic acid2',6'-Dihydroxy-4'-methoxydihydrochalconeGlycolateHeptyl acetateMedica 16alpha-Muricholic acidPaxillineCapric acidTropolonePhenolOctadecanedioic acidLauryl acetateSyringic acidMesaconic acidN6-Benzyladeninealpha-Tocopherol (Vitamin E)(-)-Bilobalide4-HydroxybenzaldehydeDL-AsparagineN2-AcetylornithineSquaric acidTriethylene glycol monomethyl etherN-Acetyl-5-Aminosalicylic Acid7-Hydroxy-3-oxo-cholest-4-en-26-oic acidGlycinealpha-Terpinyl butyrate3-Hydroxyisobutyric acidMethanesulfonic AcidOleic acidGlutaric acidSecobarbitalEmivirineResacetophenone4-Hydroxyglutamic acidN-Acetylglutamic acidHistidylcysteineGamma-GlutamyltyrosineTetrahydrocorticosteronePiperonylic acidPseudouridine8-iso-PGA12-Methyl-6-(2-(4-(4-methylsulfonylamino)benzoylpiperidin-1-yl)ethyl)pyridine2-(4-Methoxyphenyl)propan-2-ol2-Hydroxyeicosanoic acid1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineD-ArginineCynarineIsoetharine3-Hydroxytetradec-4-enedioylcarnitine4-Acetamidobenzoic acid3-(2-Hydroxyphenyl)propanoic acid3-Hydroxy-4-methoxybenzenepropanoic acidSuccinyldisalicylic acidPantothenic acid(S)-3,4-Dihydroxybutyric acid (lithium hydrate)10-Undecenoic acid4-Oxo-2-propylpentanoic acidTyrosylalanine2-(2,3-Dihydroxypropoxy)-6-(hydroxymethyl)oxane-3,4,5-triolIsovaleric acidRibothymidineOkanin-4'-O-glucosideSalicylaldehydeGlyceraldehydePristanic acid3-Hydroxydecanoic acid2'-HydroxyacetophenoneErucic acidMethyl 2-MethoxybenzoateKaempferol 3,7,4'-trimethyl ether1,3-Benzodioxole3-Oxocholic acid2-Hydroxydecanoic acidIsoamyl Laurate3-Indolyl-beta-D-glucuronideAcetylglycineFenarimolVanillic acidCaffeic Acid Phenethyl EsterN-Docosahexaenoyl Serine2-Aminooctanoic acidNorethindrone enanthate1,5-IsoquinolinediolEthyl vanillin isobutyrateHexadecanedioic acid10-Methylundecanoic acid3,4-Dihydroxybenzoic acid (Protocatechuic acid)10-Ethyl-2-propyl-6,14-dioxatricyclo[10.3.0.04,8]pentadeca-1(12),4(8)-diene-5,7,13,15-tetronePgamHomoveratric acid1-hydroxyoct-2-enoylglycine1,2-Dihydroxynaphthalene2-Aminoisobutyric acidChicoric acid2,4-Di-tert-butylphenolMaleic Hydrazide2-MethylindoleDocosapentaenoic acid (DPA)N-Butyrylglycine3-Methyluric acid1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-1-hepten-3-onep-Anisic acid9-Methyluric acid4-Ethylbenzoic AcidGlutamic acid diethyl esterN-Palmitoyl Taurine4-Acetamidobutyric acid(3R,4R)-3,4-dihydroxyoxolan-2-one3-Hydroxybenzoic acid4-HydroxyphenylacetaldehydeMalonic acidSerine2',3'-Dihydroxyacetophenonecis-11.14-Eicosadienoic acidLeucanthoside4-(Methylamino)butanoic acidDihydroxyoctadecanoic acidAndrosterone SulfateN-Methyl-L-valineLactamide3,7-Dimethyluric acidPhenylsulfateIsocitric acidGlutamylasparagineGln-AspTridecanoic acidCitronellol glucosideDurohydroquinone(R)-2-hydroxy-4-methylpentanoic acid12-Hydroxydodecanoic Acid4'-Hydroxy-3'-methylacetophenonePyrimidin-5-ol5-Hydroxy-2,4-decadienoic acid delta-lactoneGalactitolProstaglandin F2alpha (PGF2a)Isovalerylglutamic acidalpha-Methylbenzyl alcoholEthylene carbonate2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridineUric aciddelta-TETRADECALACTONE2,2-Dimethylglutaric acid2-Hydroxycinnamic acid2,4-Dihydroxybutanoic acidDL-NorvalineIsodillapioleLinoleic acidPA(16:0/18:2(9Z,12Z))Isovanillic AcidButabarbital3-Hydroxytetradecanedioic acidFumaric acid2-Hydroxydecanedioic acidIsoamyl salicylate1,1-Bis(4-hydroxyphenyl)-2,2-dichloroethylene1,2-Dihydroxyheptadec-16-en-4-yl acetateN-LactoylvalineSalsolinol-1-carboxylic acid6-Methyl-3-hepten-2-one, (3E)-3-Hydroxybutyric acidPhenylpyruvic acidUlifloxacinBenzoic acid6-Oxotetradecanoic acidC14 SphingomyelinPropentofyllineSucroseD-Alpha-aminobutyric acidStearidonic acidSuccinaldehydeBis-gamma-glutamylcystineTetradecanedioic acidTraumatic acidDodecyl gallateGlycolithocholic acid 3-sulfateLPE(16:0)Leonuriside AS1P(d16:1)O-Acetylserine2-Methyl-5-(6-methylhept-5-en-2-yl)cyclohex-3-ene-1,2-diolBiochanin a 7-sulfateCerP(d18:0/16:0)1-(2-Pyridylazo)-2-naphthol2-[3-(Sulfooxy)phenyl]acetic acidIsokobusone3-[6-[(E)-4,6-dimethyloct-2-en-2-yl]-5-methyloxan-2-yl]-4-hydroxy-5-(4-hydroxyphenyl)-1-methylpyridin-2-one2-Methyl-2-phenylsuccinimide3,5-Dimethylbenzoic acid2-(1-methyl-1H-indol-3-yl)acetic acidHexylresorcinolTaurocholic acidSultiameEthyl SulfateTerephthalic acid1-Aminopropenal acetic acid2-Ketobutyric acidIsodeoxycholic acidPE(18:0/20:3(5Z,8Z,11Z))N-Undecanoylglycine2'',6''-Di-O-acetylononinValeric acidEthyl ButylacetylaminopropionateNitrofurazoneDodecylbenzenesulphonic acidLysineButyl laurateGalabiosylceramide (d18:1/18:0)FagomineN-Octanoyl-homoserine lactoneButyllactateRaltegravir1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine4-NitroanilineMargariteneSuccinic anhydride2-MethylbutyrylglycineSuberic acid3,3'-DiaminobenzidineCeftriaxoneL-Tartaric acidgamma-CEHC (gamma-Carboxyethyl hydrochroman)5-NonadecylresorcinolProstaglandin I2 (PGI2)Hydroxyacetone5-HydroxysebacateN-Acetylserine2,6-Dihydroxybenzoic acid2-Hexyl-4-pentynoic AcidMethyl SalicylateSphalleroside AN-Acetylphenylalanine2,3-DiaminophenazineDiisopropyl adipate(5Z,8Z,11E,14Z,16E,18S)-18-hydroxyicosa-5,8,11,14,16-pentaenoic acid2-Hydroxyoctanoic acidcis-4-Octenedioic acidXanthosinePimelic acid(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-5-Hydroxy-6-(hydroxymethyl)-2-[[(1S,2S,7S,10R,11S,14S,15R,16S,17S,20S,23S)-10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracos-4-en-7-yl]oxy]-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triolDesaminotyrosineCitric acidLys-Arg2-Oxopentanoic acidPE(18:0/22:5(4Z,7Z,10Z,13Z,16Z))cis-9-Palmitoleic acid5-Aminopentanoic acidMonomethyl phthalate10-Hydroperoxy-12-[6-[pent-2-en-1-yl]-2,3-dioxabicyclo[2.2.1]heptan-5-yl]dodeca-4,7,11-trienoylcarnitineKetoprofen glucuronideDaidzein 4'-sulfateHydroxyisocaproic acidGlutathione disulfide5-Hydroxy-1-(4-Hydroxy-3-Methoxyphenyl)Decan-3-OneLinalyl butyratemethacrylamideRoseOx5-Oxotetrahydrofuran-2-carboxylic acid3-Methoxy-4-hydroxyphenylglycol sulfateGlycocholic acidMethylparabenPhe-ValItaconic acidLeu-Leu3,5-Dimethoxybenzaldehyde2,3-Dihydro-2,2-dimethyl-7-benzofuranolGlycerophosphoric acidGlucose 6-phosphate3',4'-DihydroxyacetophenoneCitronellyl Acetate2'-DeoxyuridineIndole-3-carboxaldehydeStearic acid2,3-Dimethylsuccinic acidCyclopentanoneEthyl 4-hydroxybenzoate4',5,6-Trimethylscutellarein 7-glucosideIsosakuranetin-7-neohesperidoside10-Hydroxydecanoic Acid3beta-hydroxycholest-5-en-7-one-26-oate12(S)-HHTrEDibutyl adipateBisphenol SGinsenoside Rh2Isobutyl butyrate2-Hydroxy-3-methylbutyric acidGlutamateZosteric acidN-palmitoyl-phosphoethanolamineHydroquinone2,5-DimethylphenolPE(P-16:0/20:4(5Z,8Z,11Z,14Z))5-(1-Hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3-methylpenta-2,4-dienoic acid7-[2-(1,2-Dihydroxy-3-oxooctyl)-3,5-dihydroxycyclopentyl]hept-5-enoic acidEthyl 3,4,5-trimethoxybenzoatealpha-C-MannosyltryptophanMonobutyl phthalateEthyl 4-methylpentanoate5,7-Dihydroxy-3-[4-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyphenyl]chromen-4-oneRisedronate2-Aminoadipic acidLPE(14:0)Ethyl propionatePhosphatidylserines2-Methylheptanoic acid3-Hydroxyisovaleric acidHexyl propionateDodecanoic acidGlyoxylic acidp-Dodecylbenzenesulfonic acid(S)-Mandelic acidIsopropyl isobutyrate5-Methyl-2-pyrazinecarboxylic acidLPE(0:0/16:0)Methyl OctanoatePhenylethyl primeverosidePE(P-18:1(11Z)/18:1(9Z))Apiole (parsley)N-Methylalaninecis-Aconitic acid2-Propenal, 3-(4-hydroxy-3,5-dimethoxyphenyl)-GlycerophosphoethanolaminePE(18:1(11Z)/20:4(5Z,8Z,11Z,14Z))ThymineGlycochenodeoxycholic acidDocosanedioic acid2,4-Diaminopyrimidine3-Cresol2-Hydroxyglutaric acidPelargonic acid4-Methylbenzyl alcohol2H-Pyran-2-one4-Hydroxypyridine-3-carboxamideDipalmitoylphosphatidylglycerol3-PhenylpropionylglycineN-Acetylglucosamine 1-phosphate17-Methylstearic acidCholylcysteinePantoic Acid2-MorpholinoethanolCortisol sulfateSarcosine4-Hydroxyphenylacetic acidButyl valerateN-[(4-Hydroxybenzoyl)acetyl]glycine4-Hydroxyphenylglycolic acid4-Ethoxy-3-methoxybenzaldehydeN-AcetylalaninePivalic acidDichlorpropPinolenic acidAmyl propionateDifenacoum16-Hydroxypalmitic acidTaurine3,5-Dimethylphenol8-HydroxycarbostyrilMonomethyl glutaric acidAllantoinEthyl heptanoate1,5-Anhydroglucitol3-Buten-1-olPaullinic acidLPG(18:1(9Z))Phosphatidylinositols,soya2-Methylvaleric acidFormylanthranilic acidJalapinolic acidAcetopropyl alcoholMaclurino-Toluic AcidD-ribofuranose5-Hydroxyvalproic acid5-HydroxytryptophanDiethyl glutarateTridecanedioic acidFurfuryl octanoatebeta-Alanine3-Butene-1,2-diol2,3-Dihydroxy-2-methylbutanoic acidMyristoleic acidSuccinate5,6-Dihydro-ara-uridine5-Hydroxyindole-3-acetic acidPropyl isovaleratealpha-Ketoisovaleric acidCholic acid 7-sulfateTetranorprostanedioic acidVanillin propylene glycol acetal3,4-Dihydroxyphenylacetone9-Oxooctadecanoic acidDL-Histidinetrans-Vaccenic acidomega-Aminoenantic acid1-Dodecanesulfonic acid, 1-hydroxy-3-oxo-cis-11-Eicosenoic acid5-ethenyl-1-oxo-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-6-yl hexopyranoside2-Hydroxyundecanoic acid3,4-Dihydroisocoumarin4-HydroxyprolineCholesteryl sulfateUndecanoic acidTuranose, d-2',3-Dihydroxy-4,4',6'-trimethoxychalconetrans-Aconitic acid2-(4-Methoxyphenyl)-3-methyloxiraneVanillin 4-sulfate2-(Hydroxymethyl)benzoic acid9,12-Octadecadiynoic acidFructose 1-phosphateButoxyacetic acid3-Hydroxyvaleric acidD-GlutamineN-Formylglycine3,4-Dihydro-6-methoxy-2,2-dimethyl-2H-1-benzopyran-4-ol2-Aminobutyric acidMabuterolP-Toluic AcidGentisic acidgamma-Glu-epsilon-Lys dizwitterionDiethylene glycol dimethacrylatePhosphate3-Methylcrotonylglycine4-methyl-proline5-Nonyltetrahydro-2-oxo-3-furancarboxylic acid3-Methyladipic acidAcetyltaurinePentadecanoic acidMethoxyphenylacetic acid4-Acetoxy-2-hexyltetrahydrofuran3-Chlorobenzoic Acid1-heneicosanoyl-glycero-3-phosphateN-Lauroyl Glutamine(R)-3-hydroxytetradecanoic acidtert-Butyl carbamateEthyl 3-hydroxybutyrate glucosideArecoline HydrobromideFast Violet BEicosapentaenoic acidUracil13,14-dihydro-15-keto-PGF2alpha5-Methoxyindole5-Hydroxytryptophol (5HTOL)Succinanilic acid16-Methylheptadecanoic AcidN-Acetylaminooctanoic acid2-Ethylbutyl acetate2-indolecarboxylic-acid(S)-2-methylbutanoic acidMethyl Decanoate5-Aminolevulinic acidLexipafantCaprylic acidalpha-CEHC (alpha-Carboxyethyl hydrochroman)4-Ethyloctanoic acidbeta-Phenylethanol beta-D-rutinosidebeta-Muricholic acid4-Nitrophenyl hexanoateOctyl gallate4-Ethylphenyl sulfate11beta-Hydroxyandrosterone1-Oleoyl-sn-glycerol 3-phosphate(s)-2-Amino-3-methoxypropanoic acid3-(3-Hydroxyphenyl)propanoic acid3-Nitropyrazole12-Ketolithocholic acid6-Hydroxy-5a-methyl-3,9-dimethylidenedecahydronaphtho[1,2-b]furan-2(3h)-one12-Methyltridecanoic acid11-Keto-beta-boswellic acidBenserazideCerasidin8-(4-hydroxy-3-methoxyphenyl)-6,7-bis(hydroxymethyl)-3-methoxy-5,6,7,8-tetrahydronaphthalen-2-ol3-Hydroxylauric acid5-Oxooctanoic acidMyristic acidArabitolGallic AcidAcetohydroxamic AcidPyrroloquinoline QuinoneAdipic acidAdrenic acidHomoserinegamma-Linolenic acidTyrosine O-sulfate5Z,8Z,11Z-Eicosatrienoic acid2-Oxooctanoic acid2-Phenoxyethyl isobutyrateTripelargoninPE(18:0/20:4(5Z,8Z,11Z,14Z))alpha-Linolenic acid5-Oxohexanoic acid1-PalmitoyllysophosphatidateLPE(18:1(9Z)/0:0)S1P(d18:1)3-Methoxybenzaldehydebeta-Guanidinopropionic acidEthyl 2-methylpentanoateC22 Sulfatide2-Hydroxybutyric acidOxazepam glucuronide5-Methoxy-7-(4-hydroxyphenyl)-1-phenyl-3-heptanonecis-8,11,14-Eicosatrienoic acid2-Methyl-3-hydroxybutyric acidVernolic acidGallacetophenonePE(P-18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))2-Ethyl-2-hydroxybutyric acidGlycerol 2-phosphateBenzyl methyl etherD-SerineMethyl heptanoateArachidonic acid (AA)Phenyl glucuronide2-Methylhippuric acidPentadecanedioic AcidPyruvate1,2,3-Tri-O-galloyl-beta-D-glucoseThreonic acidFructose2,2'-Iminodiacetic acidS1P(d18:0)Isobutyric acidVeratraldehydeHeptadecanoic acidCitraconic acid2-Ethylhexanoic acidPurineFA 24:6N-acetyl-3-mercapto-DL-valineMOPSPhenylacetic acidDihydroxyacetoneCaproic acidButyl butyrateN5-acetylornithine2,2-Dimethylbutyric acid3,4-Dimethylbenzoic acidKuromanin3-Hydroxyglutaric acidPalmitic acid3-(3-sulfooxyphenyl)propanoic acidsn-Glycerol 3-phosphatep-Cresol glucuronideN-AcetylmethionineAla-GlyPropyl levulinateCuprizone2-Amino-3-({hydroxy[2-(icosanoyloxy)-3-[octadec-11-enoyloxy]propoxy]phosphoryl}oxy)propanoic acid4-Hydroxycinnamic acidEthylmalonic acidGuaiacyl acetate4-Hydroxydodecanoic acidAcetylleucineGlucosidesPropionylglycine12-Ketochenodeoxycholic acid2,5-Dimethyl-2-ethylhexanoic acid[6]-ShogaolQuinaprilat2H-1,4-benzoxazin-3(4H)-oneN-Benzoyl-DL-alanine2-Methylhexanoic AcidAllocholic acidNervonic acid4-tert-Octylphenol4-Hydroxybenzoic acidArbutinGly-ValValproic acidCadabicilone1-Phenylethyl AcetateSebacic acidDocosahexaenoic acid (DHA)3-Methoxyphenylacetic acid(2E,4E)-dodeca-2,4-dienoic acid10-Nonadecenoic acid2-Hydroxystearic acid1,4-Butylenediphosphonic Acid2-(4-Allyl-2-methoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)-1-propanolCis-4-Hydroxy-L-Proline13(S)-HpOTrEHomovanillic acid sulfate3,5-DihydroxyacetophenonePropyl hexanoateMethyl anisateIsonipecotic AcidMethyl phenylacetate3-Methylglutaric acid7-Ketodeoxycholic acidEllagic AcidPE(18:0/18:2)N-Eicosapentaenoyl Arginine2-Butynedioic acidL-Gulonic acid, gamma-lactoneEthyl 2-hydroxy-4-methylvalerateSkatole1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, 5,5-dioxide, (3aS,4S,6aR)-10,16-Dihydroxyhexadecanoic acid2,3-Dihydroxybenzoic acid (Pyrocatechuic acid)2-MethylphenolMannitolPyroglutamic acid(8S)-8-amino-7-oxononanoic acidN-Methylglutamic acidPE(P-18:1(11Z)/16:1(9Z))NoreugeninHydroxyphenyllactic acidDerenofyllineSalicylic acidN-LactoylphenylalanineAllyl IsothiocyanateAmorfrutin ADodecanedioic acidPinoquercetinPG(18:1/18:1(9Z))Xanthine4-Hydroxybenzyl cyanide5-Methoxysalicylic acid5-Hydroxy-1-methylhydantoinDodecyl isobutyrateFructose 6-phosphate2,6-Di-tert-butyl-4-methylphenol19,20-DiHDPASenecialdehydeQuinic acidPhloroglucinaldehyde1-Stearoylglycerophosphoserine2,4-Dihydroxybenzoic acid4-Oxobutanoic acid3-Cresotinic acidLeucylphenylalanineMethyl phenylglyoxalate2-(3,4-Dihydroxy-5-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-5,7-dihydroxy-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-onePG(16:0/18:1)3-(Cyclohexylamino)-2-hydroxy-1-propanesulfonic acidDihydrocaffeic acid 3-sulfateThymidine2-Hydroxyhexanoic acid14-MethylhexadecanoicacidUrsodeoxycholic acidPhenylethyl AlcoholIsocaproic acidOrotic acidD-Alanine3-Hydroxypyruvic acidClavulanic AcidIsoursodeoxycholic acid3-Oxododecanoic acidDocebenoneEthyl DodecanoateGluconic acid1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoserineIndoxyl sulfate3-Amino-4-methylpentanoic acidAdipoylglycineTheanineIndole-3-pyruvic acidUndecanedioic acidN-Acetyltyrosine2-Hydroxy-2-methylbutyric acid3,5-Dihydroxydecanoic acid[4-(1,2-Dihydroxyethyl)-2-methoxyphenyl]oxidanesulfonic acidNonadecanoic acidOxypurinol3,4-Dihydrocoumarin1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphate1-Methoxy-4-MethylbenzeneZinterolDiglycineThr-ProIsovalerylglycineValproic acid glucuronideMethionine sulfoxideButanoic acid4-Hydroxy-2,5,6-trichloroisophthalonitrile3-Methylvaleric acid(-)-Methyl jasmonatealpha-amino-1H-pyrazole-1-propanoic acidAzelaic acidIsobutyl isovalerateCholyltyrosine2-[4-[3-[3,4-Dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-7-hydroxy-2,3-dihydrochromen-4-oneN-Cinnamoylglycine1-O-Hexadecyl-lyso-sn-glycero-3-phosphocholine2-Hydroxyhexanedioic acidPropylphosphonic acid2-Hydroxymyristic acidD-AsparagineLactic Acid, L-Salicyluric acid3,4-DihydroxyphenylglycolN-arachidonoyl-phenylalanineAnisyl acetateEthyl 3-oxohexanoate2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamineAdibendanLaprafyllineDeoxycholic acidCyclohexanecarboxylic acid7-Amino-4-methylcoumarinDeoxycytidine6,7,4'-TrihydroxyisoflavoneIsatinPE(P-18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))2-Hydroxyphenylacetic acidNorbuprenorphineIsoamyl isobutyrateMestranolDinoseb1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamineNuclomedonefalseIntegrative Ophthalmology of Traditional Chinese and Western MedicineResearch directions include prevention and control of myopia, intervention against age-related macular degeneration, ophthalmic optical research, and research on ophthalmology-oriented artificial intelligence technologies.2026-07-212026-07-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