MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/m_MTBLS15292_LC-MS_negative_hilic-1_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/m_MTBLS15292_LC-MS_positive_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/a_MTBLS15292_LC-MS_negative_hilic-1.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/s_MTBLS15292.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/a_MTBLS15292_LC-MS_positive_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/LPS4.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/XCD4.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/Con4.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/LPS3.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/XCD1.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/Con1.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/XCD4.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/LPS1.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/LPS6.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/LPS1.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/LPS4.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/LPS5.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/XCD5.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/LPS2.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/Con4.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/Con1.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/Con6.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/Con3.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/Con6.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/LPS5.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/Con3.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/Con2.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/XCD6.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/LPS2.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/XCD3.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/XCD2.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/XCD6.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/Con5.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/XCD3.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/Con2.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/LPS3.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/Con5.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/LPS6.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/XCD5.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/NEG/XCD1.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292/FILES/DERIVED_FILES/POS/XCD2.mzMLprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15292<p>Raw mass-spectrometry files were converted to mzML with ProteoWizard before peak detection, alignment, and retention-time correction in XCMS. Features absent from more than 50% of all samples were excluded. Missing observations in the remaining data were addressed using KNN together with one-fifth-minimum imputation: values with a missing proportion above 50% were assigned one fifth of the minimum, whereas values with a missing proportion below 50% were estimated by KNN. Support vector regression (SVR) was subsequently applied to normalize peak areas.</p><p>For annotation, the normalized and filtered features were queried against an internal laboratory library, integrated public resources, and prediction databases. Assignments were retained only when the overall identification score exceeded 0.5 and the coefficient of variation (CV) in quality-control (QC) samples was below 0.3. Positive- and negative-ion records were consolidated by retaining the entry with the highest identification confidence and lowest CV, thereby generating the final metabolite matrix.</p><p><br></p>MetaboLightsPublicLiquid Chromatography MS - positive - hilicLiquid Chromatography MS - negative - hilic<p>Chromatographic column: Waters ACQUITY Premier HSS T3 Column, 1.8 µm, 2.1 mm × 100 mm; Mobile phase A: 0.1% formic acid/water; Mobile phase B: 0.1% formic acid/acetonitrile; Instrument column temperature: 40 °C; Flow rate: 0.4 mL/min; Injection volume: 4 μL</p>Integrated transcriptomic and metabolomic analyses identify key metabolites and genes in sepsis-associated acute lung injury.The Second Affiliated Hospital of Liaoning University of Traditional Chinese MedicineHe Huangblood serummass spectrometry assay<p>Remove the sample from a-80 °C freezer and place it on ice to thaw until no ice crystals remain in the sample (all subsequent operations shall be performed on ice); After thawing the sample, vortex for 10 s to mix thoroughly, then transfer 50 μL of the sample to a corresponding numbered centrifuge tube; Add 300 μL of a 20 % acetonitrile–methanol internal standard extraction solution, vortex for 3 min, and centrifuge at 12,000 rpm for 10 min at 4 °C;Following centrifugation, transfer 200 μL of the supernatant to another corresponding numbered centrifuge tube, and let it stand at-20 °C for 30 min; Centrifuge again at 12,000 rpm for 3 min at 4 °C, then transfer 180 μL of the supernatant to the liner tube of the corresponding injection vial for instrument analysis.</p>Rattus norvegicushttps://www.ebi.ac.uk/metabolights/MTBLS15292He Huang. The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine. hhe_2yuan@163.com.<p>The raw mass spectrometry data were first converted from mzXML format to mzML format using ProteoWizard; peak extraction was then performed using the XCMS software, followed by alignment and retention time correction. Peaks with a missing rate&gt;50% in each sample group were filtered out; blank values were imputed using the KNN method combined with the 1/5 minimum value (for blank values&gt;50%, imputation was performed using the 1/5 minimum value; for blank values &lt;50%, imputation was performed using the KNN method); finally, the peak areas were corrected using the Support Vector Regression (SVR) method. The filtered peaks were subsequently used for metabolite identification by searching against the laboratory's proprietary database, integrating public databases, and utilizing predictive databases. Ultimately, compounds with an integrated identification score ≥0.5 and a Quality Control (QC) sample coefficient of variation (CV) value &lt;0.3 were selected, after which positive and negative mode data were merged—retaining the compounds with the highest qualitative confidence level and the smallest CV value.</p>Treatmenthhe_2yuan@163.com<p>Euthanasia was performed by injecting propofol emulsion&nbsp;(60mg/kg)&nbsp;via the tail vein, after which blood was collected from the abdominal aorta. After centrifugation, collect the serum in a sterile, enzyme-free EP tube using a laminar flow hood; seal the tube with a sealing film, flash-freeze it in liquid nitrogen, and store it at –80 °C.</p>MetabolomicsThermo Scientific Vanquish UHPLC SystemMetabolomicsProteoWizard msconvertuntargeted analysisThermo Scientific Q Exactive HF-XRattus norvegicusblood serumThermo Fisher Scientific (United States)experimental blankacute lung injuryuntargeted metabolite profilingThermo Scientific Vanquish UHPLC SystemMetabolomicsProteoWizard msconvertuntargeted analysisThermo Scientific Q Exactive HF-XRattus norvegicusblood serumThermo Fisher Scientific (United States)experimental blankacute lung injuryuntargeted metabolite profiling<p>Data acquisition alternated full-scan MS with data-dependent MS/MS under dynamic-exclusion conditions. Electrospray ionization was operated in positive and negative modes across m/z 75-1000 at a resolving power of 35,000. The remaining parameters were set as follows: spray voltage, 3.5 kV in positive mode and 3.2 kV in negative mode; sheath gas, 30 Arb; auxiliary gas, 5; ion-transfer-tube temperature, 320 °C; vaporizer temperature, 300 °C; collision energies, 30, 40, and 50 V; signal-intensity threshold, 1.00E+06 cps; Top N/Top speed, 10; and exclusion duration, 3 s.</p>cis-11-Methyl-2-dodecenoic acid4,6-Dinitro-O-cresol[(2R)-1-[(Z)-octadec-11-enoyl]oxy-3-phosphonooxypropan-2-yl] tetracosanoatecis-3-Hexenyl pyruvatePyrocatecholCysteylalanineDG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/16:1(9Z)/0:0)Verrucarin A2-Butyne-1,4-diolPropyl 1-(propylsulfinyl)propyl disulfide5,8,11,14-Eicosatetraenoic acid, (1R)-1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxooctadecyl)oxy]ethyl ester, (5Z,8Z,11Z,14Z)-Ketoleucine3-Methylcrotonyl GlycineCis-8,11,14,17-Eicosatetraenoic acidGPEtn(16:0p/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-Octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)Trichloroethanol glucuronide10-HDoHEFFA(18:1)Erythrinasinate A1-KestoseCarboprost1,2-Dioctadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)4-Hydroxyphenyl-2-propionic acidN-Acetyl-D-tryptophan4-HydroxybenzaldehydePE-NMe2(16:1(9Z)/16:1(9Z))Mevinphos1-(9Z-octadecenoyl)-2-(11Z-eicosenoyl)-sn-glycerolIsoelemicin1-Stearoyl-2-palmitoyl-sn-glycero-3-phosphocholinePE-NMe(18:1(9Z)/15:0)(6R,8Z)-6-Hydroxy-3-oxotetradecenoic acidTerpinyl isobutyratethromboxane B2alpha-Fluoro-beta-alanineN-PhenylacetylglycinePE-NMe(14:1(9Z)/14:1(9Z))(9E,11E)-Octadecadienoic acidEthylene brassylateD-Alanyl-alanyl-poly(glycerolphosphate)Myxalamid S1-O-trans-Cinnamoyl-beta-D-glucopyranose4-(1,1,3,3-Tetramethylbutyl)-phenol3-Oxoadipic acidPS(20:5(5Z,8Z,11Z,14Z,17Z)/22:5(7Z,10Z,13Z,16Z,19Z))Pantothenic acidPE-NMe2(18:0/22:4(7Z,10Z,13Z,16Z))D-Pyroglutamic acidD-Lyxosedihydromonacolin L acidGlyceraldehydeGlycochenodeoxycholic acid 7-sulfateUrsocholic acid2-(Methylthio)pyrazineXanthurenic acidIndoleacetaldehydeChlorimuronDimethisteroneAcetylglycinePS(20:4(5Z,8Z,11Z,14Z)/22:5(7Z,10Z,13Z,16Z,19Z))1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineMaleimide3-Furoic acid3-tert-Butyl-4-hydroxyanisoleProstaglandin D3Mosinone A4-HydroxyquinolineRhamnose1,3-BenzenediolAmyl propyl ketoneN-Palmitoyl TaurineNorambreinolide(1R,8S,9S)-3,4-dihydroxy-8-methoxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadeca-2,4,6-trien-15-one3-Hydroxybenzoic acidIbotenic acidFusidic acidContignasterolFFA(16:0)2,2'-Dipyridylamine2-HydroxyibuprofenIsocitric acidMonomethyl fumarate8-GeranylumbelliferoneSulfoglycolithocholic acidLPE(0:0/18:2)Dihydroferulic acidTagatose9'-Carboxy-alpha-chromanolTri-trans,poly-cis-undecaprenyl diphosphateUric acid(2S)-6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydroinden-1-oneFFA(16:1)EupatilinDigalacturonateTriamcinolone1-Eicosanoyl-2-docosanoyl-glycero-3-phosphoserine3-Hydroxybutyric acidL-Phenylalanine(R)-DihydromaleimideUnii-yxj027jnd6D-Quinovose3,4-Dihydroxybenzeneacetic acidTetradecanedioic acidTraumatic acidDocosahexaenoic acidErythritolChloroacetaldehyde1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine2-(Acetamidomethylidene)succinic acid(R)-2-Oxo-3-methylpentanoateCerberin2-Ketobutyric acidN-Undecanoylglycine[(2R)-1-pentadecanoyloxy-3-phosphonooxypropan-2-yl] (Z)-tetracos-15-enoatePS(20:0/22:5(7Z,10Z,13Z,16Z,19Z))AcetaminophenPhenylethylmalonamide2-MethylcyclododecanoneArsenic acid(+)-trans-Chrysanthemic acidTyrosylleucine(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acidSuccinic anhydride2-Methyl-1-propenethiol5-BromopyrimidineStramonin B1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineApigenin 7,4'-dimethyl etherThiourea1,2-Diacylglycerol-LD-PI-poolLPC(16:0/0:0)PE-NMe2(20:3(8Z,11Z,14Z)/18:2(9Z,12Z))Spinoside ALPA(18:2(9Z,12Z)/0:0)Petroselinic acidGlu-ValXanthosine(20S)-20-Hydroxypregn-4-en-3-oneCitric acidTyrphostin A25Bilastine3-Hydroxy-3-methyloxindole¦Á-Ketoglutaric Acid (¦Á-KG)Maleamic acidFFA(14:0)Benzeneacetonitrile5-O-phosphono-alpha-D-ribofuranoseTauroursodeoxycholic acidGlycocholic acidZingeroneN-Acetylimidazole2'-Deoxyuridine2,7-Dihydroxy-5-methyl-1-naphthoic acid8-Hydroxy-7-methoxycoumarinIndole-3-carboxaldehydeStearic acid1-(9Z,12Z-octadecadienoyl)-2-pentadecanoyl-glycero-3-phosphocholineD-CysteinePS(20:4(8Z,11Z,14Z,17Z)/22:5(7Z,10Z,13Z,16Z,19Z))Cinnamoylglycine1,1-DichloroethanePolymannoseHydroquinoneLycodine1,2-dilinoleoyl-sn-glycero-3-phospho-1D-myo-inositolMonobutyl phthalate(R)-3,7-Dimethyl-1,6-octadien-3-olTaurochenodeoxycholic acidPE-NMe(18:1(9Z)/18:1(9Z))PractololAgroclavineAlpha-Ketooctanoic acid12-Oxo-2,3-dinor-10,15-phytodienoic acidPropylthiouracil1,3-Dimethyl-8-isoquinolinolDehydrochorismic acidtrans-2-Hexenyl acetateChlorpropamidePhosphatidylserine4-Carboxypyrazole8-DesoxygartaninHSO3-ChloroformGramine13,16,19-Docosatrienoic acidPhenol glucuronide3-Oxopentanoic acidN-Feruloylaspartic acid(alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform A (protein)Pelargonic acidDL-LeucinePS(22:4(7Z,10Z,13Z,16Z)/22:5(7Z,10Z,13Z,16Z,19Z))LPE(0:0/16:1)MaltolSarcosine1-Octenylsuccinic anhydrideKikkanol ASorbitolTaurine6-[4-(1-carboxyethyl)phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acidHydrocinnamic acid3-Fluoro-D-alaninep-Cresol sulfate4-Fluoro-2-(trifluoromethyl)anilineTalinolol2-Hydroxybenzaldehyde3-(7-hydroxy-5-methoxy-2,2-dimethyl-2H-chromen-6-yl)-1-phenylprop-2-en-1-oneL-ThreonineNelfinavirPE-NMe2(18:1(9Z)/22:4(7Z,10Z,13Z,16Z))3-Methyl-1-(2,4,6-trihydroxyphenyl)-1-butanone8-Amino-7-oxononanoic acidCyclododecanoneHydroxyvalerenic AcidDapsone hydroxylamineMyristoleic acidL-LeucineBenzenesulfonic acid, undecyl-Yuzu-LactoneN-Acetyl-D-glucosamineIriomoteolide 1a3-Azaniumyl-4-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)amino]-4-oxobutanoate3,4-Dimethyl-1,2-cyclopentanedionetrans-Vaccenic acid12-PAHSA9-Methylxanthine4-ChlorophenolSarcostin3-Hydroxydodecanoic acidSuccinimide9(S)-HpODE9-FluorenoneImiquimodPyrrole-2-carboxylic acid9,10-EpOMESaran1,1-Dimethoxynonanecis,cis-Muconic acidAmmelide3-(N-Nitrosomethylamino)propionitrileL-TryptophanLPC(15:0/0:0)2,3,6-Trichlorobenzoic acidIsopropylcyclohexane4-Hydroxycrotonic acidTamarixetinLPA(i-20:0/0:0)Epiandrosterone3,4-Dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl) 1H-2-benzopyran-1-oneBitocholic acidFFA(22:5)8,15-DiheteEicosadienoic acidHydroxychlorEicosapentaenoic acidUracilTryptamineLPA(20:2(11Z,14Z)/0:0)8,9-Epoxyeicosatrienoic acid1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine3-Methylbenzaldehyde1-Palmitoyl-2-(1-enyl-stearoyl)-sn-glycero-3-phosphocholineSphingosine 1-phosphate(2S)-2-phenyl-2-[(2S,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyacetonitrile9-Oxo-nonanoic acidGlucosereductoneBehenic acidCaracurine V6-({5,13-dihydroxy-9-oxo-8,17-dioxatetracyclo[8.7.0.0(2),.0(1)(1),(1)]heptadeca-1(10),2(7),3,5,11,13,15-heptaen-14-yl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acidPubescenol2-Mercaptoethanesulfonic acid1,3-Dinitropyrene5-Methylthiazole4-Hydroxymandelonitrile12-Ketolithocholic acid2-Hydroxy-2,6,6-trimethylcyclohexanone1-Oleoyl-2-palmitoleoyl-sn-glycerol13-Methyloxacyclotetradecan-2-oneHydroxyquinoline3-carboxy-2,3-dihydroxypropanoateChloroacetyl chlorideParaxanthine(3S,5R,6R,7E)-3,5,6-Trihydroxy-7-megastigmen-9-one(¡À)5-HETE6-UndecanoneAcetic acidAdipic acid(17alpha,23S)-Epoxy-28,29-dihydroxy-27-norlanost-8-ene-3,24-dioneAdrenic acidN-Methyl-a-aminoisobutyric acid2-Methoxyhydroquinone(-)-9,10-Dihydrojasmonic acid2-PyridinemethanethiolHalofenozidePS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:4(7Z,10Z,13Z,16Z))LPC(18:0/0:0)PA(18:4(6Z,9Z,12Z,15Z)/18:4(6Z,9Z,12Z,15Z))2-Methyl-3-hexanoneMethylgingerolL-Glutamic acid2-Methyl-3-hydroxybutyric acidL-HomocystineCanrenone3,4-Methyleneadipic acid11-Dodecenoic acid2-Octanamidoacetic acidPE-NMe(20:3(5Z,8Z,11Z)/15:0)Fructoseprostaglandin B2PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/18:1(11Z))12-HOMEHeptadecanoic acid1,3-Dihydroimidazol-2-oneDimethylglycineTerpendole E12-Oxo-phytodienoic acidN-Acetyl-L-phenylalanineFFA(10:0)Alginic acidMollicellin I2-HeptenalMonoethyl malonic acidPteridine14,15-Leukotriene C4(ExC4)3-Hydroxyglutaric acidHistidine16-Hydroxyhexadecanoic acidPrehumulinic acid1-Eicosanoyl-glycero-3-phospho-(1'-myo-inositol)3,5-Dihydroxybenzoic acid4-Hydroxycinnamic acidTrichloroacetic acid3-Oxodecanoic acidGlycerol TributyrateD-KynurenineNervonic acid3,4,5-trihydroxy-6-{[7-methoxy-4-oxo-2-phenyl-8-(3,4,5-trihydroxyoxan-2-yl)-4H-chromen-5-yl]oxy}oxane-2-carboxylic acid1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine12-Hydroxydodecanoic acid5,6-DHETNalidixic acidMelezitoseL-Gulonolactone1-Chloro-2-methylpropeneCysteinylglycine1-stearoyl-sn-glycero-3-phospho-1D-myo-inositol3-Methylglutaric acidPE-NMe(16:0/16:0)Ethionamide(2S)-2-amino-3-[hydroxy-[(2R)-2-[(Z)-icos-11-enoyl]oxy-3-[(Z)-octadec-11-enoyl]oxypropoxy]phosphoryl]oxypropanoic acid12S-HHTSuccinic acid semialdehyde8-Chlorotheophylline9-Decenoic acid14,15-Epoxyeicosa-5z-enoic acid4-Hydroxy-3-methylbenzoic acid3-Hydroxyoctanoic acidN-methyl-4-aminobutyric acidHydroxyphenyllactic acidN,N¡ä-dicyclohexylcarbodiimide2-MethylguanosineLevulinic acidN-Lactoylisoleucine{[4-(4-hydroxy-3-methoxyphenyl)-2-oxobut-3-en-1-yl]oxy}sulfonic acidMarmesinPS(22:0/20:3(8Z,11Z,14Z))2-n-Propyl-4-oxopentanoic acid1-StearoylglycerophosphoserineDichlorprop-PBromomethaneCaryoptinTyrphostin 23L-Isoleucine1,3,5-Trichloro-2-methoxybenzeneFFA(19:1)2-Hydroxy-3-isopropylsuccinic acidLPE(0:0/20:3)2-hydroxyacrylic Acid(+)-phytocassane E1-Methyl-3-(2-methyl-2-propenyl)-cyclopentane7-MethylxanthineIndoxyl sulfate13-Tetradecanolide3-(Methylthio)thiopheneUndecanedioic acidMethylselenocysteine Se-oxidePhenobarbital2-Mercaptobenzothiazole2-Hydroxy-2-methylbutyric acidL-Aspartic acidSedoheptulose2,3-DihydrothiopheneCarvacrol3,4-Dihydroxyhydrocinnamic acidPentadec-3-enalL-3-Phenyllactic acid4-Hydroxyphenylpyruvic acidp-Cresol2-Hydroxymyristic acidIndolmycinHexadecenoic acidDL-GlutamineGlycolaldehydeHomodihydrojasmone10-Hydroxy-8-nor-2-fenchanone glucosideIndole-3-carboxylic acidXylitolCyclohexanecarboxylic acidNeogrifolin1,5-Diphenylcarbazide1-Heptadecanoyl-sn-glycero-3-phosphocholine1-oleoyl-2-arachidonoyl-sn-glycero-3-phospho-1D-myo-inositolprostaglandin J22,3-Dimercaptosuccinic acidMethylmalonic Acid1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamineN-IsovaleroylglycineD-Tartaric acidIsoguvacine2-Methyl-5-(8,11-pentadecadienyl)-1,3-benzenediol2-Acetamido-3-methylbutanoic acidPS(22:5(7Z,10Z,13Z,16Z,19Z)/22:5(4Z,7Z,10Z,13Z,16Z))Glu-Leu11-Oxohexadecanoic acidHexanoylglycine2-Methylbenzoic acidPS(20:4(8Z,11Z,14Z,17Z)/22:5(4Z,7Z,10Z,13Z,16Z))HydroxyflutamideHarmanFucoxanthinMedica 163-Hydroxy-6,8-dimethoxy-7(11)-eremophilen-12,8-olide1,2-Didecanoyl-sn-glycero-3-phosphocholine1-MethylxanthinePhenol1-beta-D-GalactosylsphingosinePE-NMe(20:0/24:1(15Z))PS(22:5(7Z,10Z,13Z,16Z,19Z)/22:5(7Z,10Z,13Z,16Z,19Z))LPA(20:4(8Z,11Z,14Z,17Z)/0:0)[2-hydroxy-3-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphateGlutaric acidSclareol2-HydroxycineolGeraniolexo,exo-1,8-Epoxy-p-menthane-2,6-diolMonoethyl carbonate2-Ethyl-2-Hydroxybutyric acidLPE(18:1/0:0)[(2R)-1-decanoyloxy-3-phosphonooxypropan-2-yl] 10-methyldodecanoateMethylthiouracilIsovaleric acid3-Hydroxydecanoic acid2'-HydroxyacetophenoneDL-ProlineMyricetin3,4,5-trihydroxy-6-[2-methoxy-5-(3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-2-yl)phenoxy]oxane-2-carboxylic acid4-Methoxycinnamic acidOleoyltaurinePE-NMe2(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/24:0)3-MethylxanthineGentioflavineKeto-Deoxy-Nonulonic acidGlyceric acid1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholinePE-NMe2(20:2(11Z,14Z)/14:1(9Z))Hexadecanedioic acidHelenalinValeraldehyde dibutyl acetalD6-Ambrettolide2-Indolecarboxylic acidtrans-trans-Muconic acidUridineLPE(20:4/0:0)StreptozocinImidazole-4-acetaldehyde1-Acetyl-2-methylcyclopentene[(1S,4aS,7S,7aR)-4-(acetyloxymethyl)-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-1-yl] 3-methylbutanoate3-Hydroxymethylglutaric acid2-AcetamidophenolLiquiritin1,2-DichloroethaneN-Methyltryptamine1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine2-Hydroxy-3-(sulfooxy)benzoic acidGlycoursodeoxycholic acidPhosphoroselenoic acid2,4-Dihydroxyhept-2-enedioic acidTetracosahexaenoic acid, n-32-Fluorobenzoic acidHomogentisic acidDihydro-2(3H)-thiophenoneL-TyrosinePE-NMe2(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/14:0)Dihydroconiferyl alcoholHypotaurineProstratinPC(16:0/20:4(5Z,8Z,11Z,14Z))4-Oxo-4-(pyridin-3-yl)butanoic acid2,4,6-Trinitrotoluene2-Methyl-1,3-cyclohexadienePhosfolan2-Oleoyl-sn-glycero-3-phosphocholinelipid XPterin-6-carboxylic acid4-Trimethylammoniobutanoic acidTriclofos10,11-Epoxy-3-geranylgeranylindole2-Pyrocatechuic acidCortexolone2-Acetylpyridine2,5-DihydroxybenzaldehydeIndole-5,6-quinone1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholineLPC(0:0/16:0)Taurocholic acidAsulam2-Dodecylbenzenesulfonic acid4-CyanopyridineHydroxyclomipramine glucuronide1,3-Dimethyluric acidPS(20:3(8Z,11Z,14Z)/20:4(8Z,11Z,14Z,17Z))LPE(18:0/0:0)PE-NMe2(18:0/18:2(9Z,12Z))LPS(18:2)4-ene-Valproic acidPotassium bicarbonatePsicoseMethyloxirane2,4-Dichlorobenzoic acidPS(22:4(7Z,10Z,13Z,16Z)/18:3(9Z,12Z,15Z))Suberic acid5-HydroxyindoleacetaldehydeAcetylsalicylic acid1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-N,N-dimethylethanolaminetrans,octacis-decaprenylphospho-beta-D-ribofuranoseAstemizole4-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-[5-[(2R,3S)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-hydroxy-3-methoxyphenyl]-6-methoxyphenolIcaceinePrunasinPE-NMe2(16:0/18:3(9Z,12Z,15Z))CreatininePS(18:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))PE-NMe2(18:2(9Z,12Z)/20:3(5Z,8Z,11Z))Farnesyl phosphate1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)(S)-3,7-Dimethyl-1,6-octadienePimelic acidcis-7-Hexadecenoic acid3-(3,4,5-Trimethoxyphenyl)propanoic acidPE-NMe2(16:0/16:1(9Z))Lpa(0:0/18:2(9Z,12Z))1-(9Z-hexadecenoyl)-2-tetradecanoyl-glycero-3-phosphateGlycolithocholic acidN-Acetylleucinebeta-Tocotrienol1,4-Cineole12-(9Z-hexadecenoyloxy)-octadecanoic acidGamma-Mercholic Acid3,8-Dihydroxy-1-methylanthraquinone-2-carboxylic acid14,19-DihydroaspidospermatineTiglic acid1-pentadecanoyl-2-(11Z,14Z-eicosadienoyl)-glycero-3-phosphate2-(2-Aminoethyl)pyridine3-Methoxy-4-hydroxyphenylglycol sulfate2-ethyl-2-hydroxy-3-oxobutanoateHydroprene2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acidItaconic acid4-Formyl-2-methoxyphenyl acetateL-AlanineN-MethylhydantoinJasmonic acidNorethindrone acetateN-Phenyl-2-naphthylamine2-PropylthiopheneAll-trans-heptaprenyl diphosphatePC(18:0/18:2)1-Stearoyl-2-myristoyl-sn-glycero-3-phosphocholine1-Stearoyl-2-oleoyl-sn-glycero-3-phosphocholine13(S)-Hydroperoxylinolenic acid1-(4-Hydroxy-3-methoxyphenyl)-3-decanoneAtorvastatinL-Lysine[(2R)-1-octanoyloxy-3-phosphonooxypropan-2-yl] tetradecanoateS-(2-aminoethyl)cysteineSuxibuzoneprostaglandin G2 2-glyceryl ester3-Hydroxyisovaleric acidHydrocortisoneDodecanoic acid1-Nonene10-Hydroxydecanoic acidGrifolinTris(2-butoxyethyl) phosphatePhytolaccasaponin G4-Methylvaleric Acid5beta-Cholanic acid5-Oxo-4,5-dihydro-2-furylacetic acidCadusafos[2-(Dimethoxymethyl)-1-heptenyl]benzenePiperalolThreoninyl-Cysteine2-Carboxy-5,7-dimethyl-4-octanolideD-Ribulose 1,5-bisphosphateHyodeoxycholic acidCyanophosButylated hydroxytolueneRosiglitazoneLactic acid(2S)-2-amino-3-[hydroxy-[(2R)-2-tetracosanoyloxy-3-tetradecanoyloxypropoxy]phosphoryl]oxypropanoic acid3-Chloro-2-methylpropeneDichlorprop1,4-CyclohexanedioneD-Fructose9S-HOTrEEmbelinAllantoinPE-NMe(15:0/20:1(11Z))3-hydroxy-3-(3-hydroxyphenyl)propanoic acid-O-sulphateFormylanthranilic acid(9Z,12S,13R)-12,13-Dihydroxy-9-octadecenoic acid3-Mercapto-2-butanolPE-NMe2(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/20:0)9(S)-HPODE1,11-Undecanedicarboxylic acidCys-TyrLPC(O-16:0/2:0)3-Indoleacrylic acidDivinyl sulfiderac-4-Hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinyl acetate2,8-QuinolinediolPicrotinHydroxystilbamidineMethioninealpha-Ketoisovaleric acid2,2,2-Trifluoroethanol3-Hydroxynonyl acetateTyrosolGemfibrozil[8]-DehydrogingerdioneRosmarinic acid[(2R)-1-octanoyloxy-3-phosphonooxypropan-2-yl] 12-methyltetradecanoate4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanolxi-3-Hydroxy-2-oxobutanoic acidCys-Cys1,1-Bis(p-chlorophenyl)-2-chloroethane3-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acidL-NorleucineGlycolic acidPentadecanoic acidSotalolPsilocinLPS(18:1/0:0)1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineSerotoninp-CoumaraldehydeKojic acid1-docosanoyl-2-(11Z,14Z-eicosadienoyl)-glycero-3-phosphoserine3-[4-Methyl-1-(2-methylpropanoyl)-3-oxocyclohexyl]butanoic acidSciadonic acid1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineIndole-3-propionic acidFerimzone3-Methyl-2-butenyl beta-D-glucopyranoside5-(3-Hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene1,2,3,4-BenzenetetrolDipalmitoyl phosphatidylinositolXanthotoxolBisnorcholic acidValerenic acid1-Stearoyl-2-(1-enyl-palmitoyl)-sn-glycero-3-phosphocholine2-[(2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione2'-Deoxyuridine 5'-monophosphate3-Hydroxytetradecanoic acidLovastatin acidIsodonal5-(2-Methylpropyl)tetrahydro-2-oxo-3-furancarboxylic acidalpha-Hydroxyisobutyric acid(1alpha,4alpha,5beta,6alpha,11betaH)-1,4-Epoxy-5-hydroxy-10(14)-germacren-12,6-olide(1(10)E,4a,5E)-1(10),5-Germacradiene-12-acetoxy-4,11-diol3,5-Dinitrocatechol(¡À)12-HEPEPA(18:2(9Z,12Z)/18:2(9Z,12Z))MephenytoinSuccinic acidm-Chlorohippuric acid16-Methylheptadecanoic acid2,4-DinitrophenolPsilocybineMethimazole1,2-Dioleoyl-sn-Glycero-3-PhosphocholineNevirapineHippuric acidPE(18:0/20:4(5Z,8Z,11Z,14Z))Notoginsenoside R1Arabinose1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateCibulinsVernolic acidBenzene oxidePhenobenzuron2-Chloro-1,1,1-trifluoroethaneAdenineAustidiolOxoadipic acidIsobutyric acidD-Proline4-MethylcyclohexanoneIsoxazolin-5-oneL-SerinePurine(6E,8R,10Z)-8-hydroxy-3-oxohexadecadienoic acid6-Hydroxy-3,4-dihydro-2(1H)-quinolinoneDioleoyl phosphatidylserineCholic acid glucuronidePanthenolCholic acidArachidonic acidPE-NMe2(18:2(9Z,12Z)/18:3(6Z,9Z,12Z))LPE(16:0/0:0)1-Phenyl-1,3-hexadecanedioneFirefly luciferinErythorbic acid1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamineValylcysteineMethyl 3-methyl-2-oxopentanoateCaffeine3'-Fucosyllactose3-HydroxybenzaldehydeAllocholic acid6-Aminopenicillanic acidMoschamineValproic acidMenadiol disulfate(S)-14-Methylhexadecanoic acidDodecanal dimethyl acetal4-Hydroxy-1H-indole-3-carboxylic acidPyronaridineMeconic acid(¡À)12-HETESphinganine 1-phosphateThreitolDioxindoleTheophylline5-[(E)-2-(2,4-dihydroxyphenyl)ethenyl]-4-methoxy-2-(3-methylbut-2-en-1-yl)benzene-1,3-diolPS(18:2(9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z))Atractylenolide III1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine7-Ketodeoxycholic acidAcetylenedicarboxylic acidPA(22:5(7Z,10Z,13Z,16Z,19Z)/18:4(6Z,9Z,12Z,15Z))Avocadene 4-acetatebis(3-methylbut-2-en-1-yl)benzene-1,2,3,5-tetrol(8Z,11Z,13E)-15-hydroxyicosa-8,11,13-trienoic acidPyroglutamic acidThyroxine1,3,5-Trihydroxybenzene3alpha-Hydroxy-5beta-pregnane-20-one sulfate(¡À)-2,2,6-TrimethylcyclohexanonePhysagulin FBotrydialDodecanedioic acid(Z,Z)-2-Methyl-5-(8,11,14-pentadecatrienyl)-1,3-benzenediol4-ImidazoloneEthoxyacetic acidL-glyceraldehyde3-Hydroxyhexadecanoic acidGingerol13alphaH-dellta8(14)-Dihydroabietic acidAllixin7,8-Dehydro-beta-micropteroxanthin1-arachidonoyl-sn-glycero-3-phospho-1D-myo-inositol2-Hydroxy-6-pentadecylbenzoic acidL-ThymidinePE-NMe2(14:1(9Z)/20:2(11Z,14Z))PA(16:0/18:4(6Z,9Z,12Z,15Z))Apigenin 7-O-(2''-O-acetylglucoside)Tauro-beta-muricholic acid2-Ketohexanoic acid2'-Hydroxy-4,4',6'-trimethoxychalcone1-eicosanoyl-2-(13Z,16Z-docosadienoyl)-glycero-3-phosphoserineFFA(18:4)3-Palmitoyl-sn-glycerol5-Acetylamino-6-formylamino-3-methyluracilOrotic acidD-AlanineFurmecycloxGluconic AcidAbscisic acidMalic acidAndrosterone sulfateDimethyl carbonateMandelic acid(3beta,5alpha,6beta,7alpha,22E,24R)-Ergosta-8,22-diene-3,5,6,7-tetrolalphaS-Amino-2-[[4S-amino-4-carboxybutyl]amino]-4H-imidazo[4,5-b]pyridine-4-hexanoic acidPE-NMe2(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))TraumatinPyruvic AcidPhenyl hydrogen sulfatePE-NMe2(20:3(5Z,8Z,11Z)/18:2(9Z,12Z))12-Hydroxystearic acidLPC(14:0/0:0)Di-trans,poly-cis-pentaprenyl diphosphateElaidic acidDinoprostoneGinkgolic acidPS(22:5(4Z,7Z,10Z,13Z,16Z)/22:4(7Z,10Z,13Z,16Z))FFA(18:2)Azelaic acidPartheninPaucin2-Azaniumylheptanoate3-(3-Methoxyphenyl)Propionic AcidL-2-Hydroxyglutaric acidPS(18:3(6Z,9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z))EpinephrineKurarinolPE-NMe2(22:2(13Z,16Z)/22:2(13Z,16Z))alpha-Dimorphecolic acid4-Chloro-L-phenylalanine3-Sulfocatechol12-Hydroxyjasmonic acidBergapten(5-Oxo-2-sulfo-2,5-dihydrofuran-2-yl)acetic acid2,5-DichlorohydroquinonePE-NMe(15:0/20:3(5Z,8Z,11Z))FAA(18:1)ProtoverinePS(20:4(5Z,8Z,11Z,14Z)/22:5(4Z,7Z,10Z,13Z,16Z))ErythruloseD-Citramalic acidDaidzeinDinosebfalseMetabolomic analyses in sepsis-associated acute lung injury rats<p>Sepsis-associated acute lung injury (SALI) is a life-threatening pulmonary complication triggered by sepsis, which carries a notably high mortality rate. We constructed a rat model of SALI and administered Xuanbai Chengqi Decoction (XCD) as treatment, after which untargeted serum metabolomics analysis was carried out to screen metabolites that respond to the intervention.Methods: Untargeted serum profiling was performed by liquid chromatography-tandem mass spectrometry&nbsp;(LC-MS/MS) for the control, LPS (ALI model), and XCD groups. Differentially accumulated metabolites between groups were identified and the related metabolic pathways of these differential metabolites were further enriched and annotated to explore the potential mechanism of XCD in treating SALI.&nbsp;</p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