{"database":"MetaboLights","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Tabular":["ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/m_MTBLS15312_LC-MS_positive_reverse-phase_v2_maf.tsv","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/m_MTBLS15312_LC-MS_negative_reverse-phase_v2_maf.tsv"],"Txt":["ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/i_Investigation.txt","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/a_MTBLS15312_LC-MS_negative_reverse-phase.txt","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/a_MTBLS15312_LC-MS_positive_reverse-phase.txt","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/s_MTBLS15312.txt"],"Mzxml":["ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/P04.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/T02.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/C01.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/P01.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/P02.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/C04.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/QC03.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/T02.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/QC01.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/P01.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/P04.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/C04.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/QC03.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/C02.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/T01.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/P03.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/T04.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/P03.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/C03.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/QC02.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/QC01.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/C02.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/T03.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/T04.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/P02.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/C03.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/C01.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/T01.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/NEG/T03.mzXML","ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312/FILES/DERIVED_FILES/POS/QC02.mzXML"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"ftp_download_link":["ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15312"],"metabolite_identification_protocol":["<p>The R package and the BiotreeDB-V3.0 were applied in metabolite</p><p>identification.</p>"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["<p>For the separation of polar metabolites, chromatographic analysis was performed on a Vanquish ultra high performance liquid chromatography (UHPLC) system (Thermo Fisher Scientific, USA) equipped with a Waters ACQUITY UPLC BEH Amide column (2.1 mm × 50 mm, 1.7 μm). The mobile phase consisted of phase A (aqueous phase containing 25 mmol/L ammonium acetate and 25 mmol/L ammonium hydroxide) and phase B (acetonitrile). The autosampler temperature was maintained at 4 °C, and the injection volume was 2 μL.</p>"],"publication":["Photosynthetic bioenergetic-redox restoration rejuvenates the aged muscle regenerative niche."],"submitter_name":["Qi Cao"],"submitter_affiliation":["Second Military Medical University"],"organism_part":["muscle"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["<p>Approximately 25 mg of each sample was accurately weighed at low temperature and transferred into an Eppendorf tube containing two homogenization beads. Then, 500 μL of extraction solution (methanol : acetonitrile : water = 2 : 2 : 1, v/v/v) containing isotope-labeled internal standards was added. The mixture was vortexed for 30 s, followed by homogenization using a homogenizer at 35 Hz for 4 min, and then subjected to ultrasonic treatment in an ice-water bath for 5 min. This homogenization-ultrasonication cycle was repeated three times. The samples were then incubated at −40 °C for 1 h, and centrifuged at 12,000 rpm (13,800 ×g, rotor radius 8.6 cm) for 15 min at 4 °C. The resulting supernatants were transferred into autosampler vials for LC MS/MS analysis. Additionally, an equal volume of supernatant from each sample was pooled to prepare quality control (QC) samples, which were analyzed under the same conditions.</p>"],"organism":["Mus musculus"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS15312"],"author":["Qi Cao. Second Military Medical University. caoq@smmu.edu.cn."],"data_transformation_protocol":["<p>The raw data were converted to the mzXML format using ProteoWizard</p><p>and processed with an in-house program. which was developed using R and</p><p>based on XCMS, for feature detection, extraction, alignment, and integration.</p>"],"study_factor":["Treatment"],"submitter_email":["caoq@smmu.edu.cn"],"sample_collection_protocol":["<p>Mice were anesthetized via intraperitoneal injection and subsequently euthanized by cervical dislocation. The gastrocnemius muscles were then carefully dissected and harvested for further experimental analysis.</p>"],"omics_type":["Metabolomics"],"study_design":["Thermo Scientific Vanquish UHPLC System","Metabolomics","Mus musculus","untargeted analysis","Thermo Scientific Orbitrap Exploris 120","muscle","Aging","skeletal muscle regeneration","experimental blank","CM-NTU-Ce"],"curator_keywords":["Thermo Scientific Vanquish UHPLC System","Metabolomics","Mus musculus","untargeted analysis","Thermo Scientific Orbitrap Exploris 120","muscle","Aging","skeletal muscle regeneration","experimental blank","CM-NTU-Ce"],"mass_spectrometry_protocol":["<p>Mass spectrometry detection was carried out on an Orbitrap Exploris 120 mass spectrometer controlled by Xcalibur software (version 4.4, Thermo Fisher Scientific), enabling both full scan MS and data dependent MS/MS acquisition. The detailed parameters were set as follows: sheath gas flow rate, 50 Arb; auxiliary gas flow rate, 15 Arb; capillary temperature, 320 °C; full MS resolution, 60,000; MS/MS resolution, 15,000; stepped normalized collision energy (NCE), 20/30/40; and spray voltage, 3.8 kV (positive ion mode) or -3.4 kV (negative ion mode).</p>"],"metabolite_name":["(2-{[2-[hexadec-9-enoyloxy]-3-(tetradecanoyloxy)propyl phosphonato]oxy}ethyl)trimethylazanium","Acamprosate (calcium)","Taurine","N-Acetyl-2-carboxybenzenesulfonamide","Allantoin","Embelin","1,5-Anhydroglucitol","2-Aminonicotinic acid","3,3-Dimethylglutaric acid","8-Oxononanoic acid","Deoxyinosine","(2S,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid","Trifluoroacetic acid","5-Hydroxyvalproic acid","2-Ketocaproic acid","Pantothenol","Succinic_acid_semialdehyde","Thiolutin","L-Erythrulose","beta-Alanine","Ketoleucine","Hexanoylglycine",".beta.-Tocotrienol","Carbamoyl_phosphate","Caplamin","Isosakuranin","Succinate","2,2',4,4'-Tetrahydroxybenzophenone","Carboxytolbutamide","alpha-Ketoisovaleric acid","(2-aminoethoxy)[3-[hexadec-1-en-1-yloxy]-2-[icosa-5.8.11.14-tetraenoyloxy]propoxy]phosphinic acid","Glycolate","4,4'-Sulfonylbisphenol","1,2-dihydroxyheptadec-16-en-4-yl acetate","Capric acid","coniferin","9-Oxooctadecanoic acid","Isomalt","Thymidine_3,5-cyclic_monophosphate","Octadecanedioic acid","trans-Vaccenic acid","1-Hydroxy-2-naphthoic acid","Gln-Ser","CARMINIC_ACID","N-Acetylaspartic acid","Mesaconic acid","cis-11-Eicosenoic acid","4-Hydroxybenzaldehyde","4-Hydroxyproline","Cholesteryl sulfate","N2-Acetylornithine","Undecanoic acid","alpha-Chaconine","Carnosine","Arabinono-1,4-lactone","Fructose 1-phosphate","3-Hydroxyvaleric acid","3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione","N-Formylglycine","gamma-Glutamylglutamic acid","lactitol","2-Aminobutyric acid","Lariciresinol","Vigabatrin","Oleic acid","Phosphate","Glutaric acid","3-(Methylsulfinyl)propylglucosinolate","PI(18:1/18:1)","Methyl-4-hydroxy-3-methoxybenzoate","Myristoleate","Pentadecanoic acid","Secoisolariciresinol","4-Hydroxyglutamic acid","3-[[4-(4-Chlorophenyl)piperazino]methyl]-1H-pyrrolo[2,3-b]pyridine","Hydroferulic acid","Phenylacetylglycine","UDP-galactose","Ser-Ser","Piperonylic acid","Pseudouridine","Gallic_acid","Terephthalic-Acid","17-ODYA","2-Methylglutaric acid","(2-aminoethoxy)[2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-[octadeca-1.9-dien-1-yloxy]propoxy]phosphinic acid","Xanthoxylin","2-keto_valeric_acid","Uracil","Eicosapentaenoic acid","N-Acetylneuraminic acid","Glu-Glu","Pantothenic acid","(2-{[3-(hexadecanoyloxy)-2-[octadeca-9.12-dienoyloxy]propyl phosphono]oxy}ethyl)trimethylazanium","5,6-Dihydroxyindole","Ribulose 5-phosphate","Isovaleric acid","Pristanic acid","3-Hydroxydecanoic acid","Leu-Val","Maltotetraose","Taurohyodeoxycholic acid","Xanthotoxol","5-Aminolevulinic acid","3-Oxocholic acid","Met-Gly","Caprylic acid","Glu-Ala","Acetylglycine","HEPTANOIC ACID","2-Oleoyl-1-stearoyl-sn-glycero-3-phosphoserine","2,3-Pentanedione","Asp-Asp","beta-Muricholic acid","Phthalic acid","2-amino-3-({[3-(hexadecanoyloxy)-2-(octadecanoyloxy)propoxy](hydroxy)phosphoryl}oxy)propanoic acid","Homoveratric acid","3-Ureidopropionic acid","2-Aminoisobutyric acid","2-Arachidonoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine","12-Methyltridecanoic acid","Lys-Ala","2-Phenyllactic acid","3-Hydroxylauric acid","Oxalic acid","Docosapentaenoic acid (DPA)","Myristic acid","Pyrophosphate","5-Carboxyfluorescein","PS(18:1/18:1)","Adipic acid","2-amino-3-({hydroxy[2-(icosanoyloxy)-3-[octadec-11-enoyloxy]propoxy]phosphoryl}oxy)propanoic acid","gamma-Linolenic acid","2'-Deoxyguanosine 5'-diphosphate (dGDP)","3-Methylthiopropionic acid","Malonic acid","Hippuric acid","alpha-Linolenic acid","cis-11.14-Eicosadienoic acid","3-[4,5-dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one","Saluamine","Uridine 5'-monophosphate (UMP)","1-Palmitoyllysophosphatidate","N-Acetylaspartylglutamate (NAAG)","2-amino-3-({hydroxy[2-[icosa-5.8.11-trienoyloxy]-3-(octadecanoyloxy)propoxy]phosphoryl}oxy)propanoic acid","beta-Guanidinopropionic acid","risedronate","Isopentenyladenine","O-Desmethylastemizole","Pyridine, 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]-","Phenylsulfate","Isocitric acid","Epicatechin gallate","Gln-Thr","Plumbagin","Homocarnosine","Gly-Ala","UDP-N-acetylglucosamine","Tetradecyl sulfate (sodium)","2-Hydroxybutyric acid","N-Lauroylglycine","2-Methyl-3-hydroxybutyric acid","Xanthone","Glucuronic acid","1,3-Dihydroxyacetone dimer","2-Ethyl-2-hydroxybutyric acid","PC(18:1(9E)/18:1(9E))","Allopurinol","Arachidonic acid (AA)","2-Methylhippuric acid","Pyruvate","Uric acid","2,4-Dihydroxybutanoic acid","2,2'-Iminodiacetic acid","Linoleic acid","Fumaric acid","Heptadecanoic acid","Citraconic acid","Sissotrin","Sulfoacetic acid","Adenosine 3',5'-diphosphate (PAP)","Thelephoric acid","2-Arachidonoyl-1-stearoyl-sn-glycero-3-phosphoethanolamine","N-3,4-Tridhydroxybenzamide","3-Hydroxybutyric acid","Benzoic acid","12(13)-Epoxy-9Z-octadecenoic acid","(2-aminoethoxy)[2-[icosa-5.8.11.14-tetraenoyloxy]-3-[octadec-1-en-1-yloxy]propoxy]phosphinic acid","Caproic acid","1,6-Anhydro-.beta.-D-glucose","Dihydroxyacetone phosphate","Methylenediphosphonic acid","Methylsuccinic acid","Mannose","Adenosine 5'-diphosphate (ADP)","Palmitic acid","Dodecyl gallate","Glycolithocholic acid 3-sulfate","Thr-Ser","1,2-Dilinolenoyl-sn-glycero-3-phosphoethanolamine","O-Acetylserine","Ala-Gly","p-Cresol glucuronide","N-Acetylmethionine","Histidine","Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-","3-Methylbut-2-enoic acid","Phe-Met-Arg-Phe-amide","6-Formylpterin","Taurocholic acid","Esculin","Propionic acid","Allocholic acid","Lonicerin","Benzamide, 2-chloro-5-nitro-N-phenyl-","Isodeoxycholic acid","Gly-Val","Valproic acid","Valeric acid","N5-acetyl-l-ornithine","Nitrofurazone","Lawsone","2-Hydroxystearic acid","Isobutyric_acid",".alpha.,.alpha.,.alpha.-Trifluorothymidine","13(S)-HpOTrE","N-Glycolylneuraminic acid","Dihydroquercetin","3-Methylglutaric acid","alpha-Ketoglutaric acid (alpha-KG)","7-Ketodeoxycholic acid","Suberic acid","FA 18:3+2O","Nicotinamide adenine dinucleotide (NAD)","Dronedarone","Aminomalonic acid","Thr-Leu","Hydroxyacetone","myo-Inositol","2-Methylphenol","Pyroglutamic acid","Mannitol","3-Hydroxyoctanoic acid","cis-_9,_10-_Epoxystearic acid","Hydroxyphenyllactic acid","Acetic acid, 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-","N-Lactoylphenylalanine","2',3'-Cyclic AMP","Levulinic acid","2-Hydroxyoctanoic acid","Isomaltose","2-Docosahexaenoyl-1-stearoyl-sn-glycero-3-phosphoethanolamine","2,2-Dimethylsuccinic acid","Xanthine","3-Methyl-2-oxovaleric acid","Desaminotyrosine","Mannose 1-phosphate","Citric acid","Fructose 6-phosphate","ADP-ribose","cis-9-Palmitoleic acid","5-Aminopentanoic acid","Quinic acid","Denticetic-acid","Asparagine","Cystine-glutathione","8-iso-15-keto-PGE2","2-Anilinopropanoic acid","Tauro-beta-muricholic acid","Hydroxyisocaproic acid","Glutathione disulfide","Lactate","N-Lauroylsarcosine",".beta.-Hydroxyphenylalanine","PG(16:0/18:1)","Tauroursodeoxycholic acid","Thymidine","9-Oxo-10(E),12(E)-octadecadienoic acid","2-Hydroxyhexanoic acid","Inosine 5'-monophosphate (IMP)","3,19,23-Trihydroxyurs-12-en-28-oic acid","Glu-Asp","Ursodeoxycholic acid","Isocaproic acid","Itaconic acid","Pantetheine","sclareol","Leu-Leu","Methylmalonic acid","Ethanesulfonic acid","2,4-dinitrotoluene","Glucose 6-phosphate","3-Hydroxypyruvic acid","Maleic acid","2'-Deoxyuridine","Malic acid","(2-aminoethoxy)[2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-[hexadec-1-en-1-yloxy]propoxy]phosphinic acid","Stearic acid","Docebenone","[2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-(octadecanoyloxy)propoxy]({[2.3.4.5.6-pentahydroxycyclohexyl]oxy})phosphinic acid","1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-myo-inositol)","Gluconic acid","Azomycin","Ethyl 4-hydroxybenzoate","myricetin-3-O-hexosyl(1-2)deoxyhexoside","Warfarin","Hydroxytyrosol acetate","Indapamide","Nitrilotriacetic acid","3-Amino-4-methylpentanoic acid","1,2-Di(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine","2-Hydroxy-3-methylbutyric acid","Cidofovir","trifolirhizin","Theanine","Glutamate","Succinic_anhydride","Glu-Ser","2-Hydroxy-2-methylbutyric acid","(2-aminoethoxy)[2-[hexadec-9-enoyloxy]-3-[octadeca-1.11-dien-1-yloxy]propoxy]phosphinic acid","MES","Oxypurinol","DL-Isocitric acid lactone","Nonadecanoic acid","Resolvin_D2","Pyruvaldehyde","N-Palmitoyltaurine","12-Hydroxystearic acid","Diglycine","Gly-Asp","Isovalerylglycine","3-Hydroxyisovaleric acid","Alanylalanine (Ala-Ala)","1-Methylhistidine","2-Methyltetrahydrofuran-3-one","Dodecanoic acid","Taurodeoxycholic acid","Azelaic acid","Fludioxonil","Lorazepam glucuronide","(2R)-2,4-Dihydroxy-3,3-dimethylbutanoic acid","(2-aminoethoxy)[2-[octadec-9-enoyloxy]-3-[octadeca-1.11-dien-1-yloxy]propoxy]phosphinic acid","cis-Aconitic acid","Glycerophosphoethanolamine","Glyoxylate","2-Hydroxyethanesulfonic acid","Thymine","Dethiobiotin","2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine","3-Cresol","2-(2-oxo-8,9-dihydrofuro[2,3-h]chromen-8-yl)propan-2-yl acetate","2-Hydroxyglutaric acid","Pelargonic acid","13(S)-HODE","Deoxycholic acid","Hyodeoxycholic acid","Quercetin_3-beta-D-glucoside","2-Docosahexaenoyl-1-stearoyl-sn-glycero-3-phosphoserine","Butylated hydroxytoluene","4-HYDROXYCYCLOHEXANECARBOXYLIC ACID","Pentachlorophenol","N-Acetylalanine","Galactose","2'-Deoxyguanosine 5'-monophosphate (dGMP)"],"additional_accession":[]},"is_claimable":false,"name":"Photosynthetic bioenergetic-redox restoration rejuvenates the aged muscle regenerative niche","description":"<p>Aging impairs muscle regeneration, but the key constraint remains unclear. Aged injured muscle fails to restore mitochondrial respiration, membrane potential, ATP/NADPH balance and redox control, forming a bioenergetic-redox bottleneck. To target this, we engineered CM-NTU-Ce, a C2C12 membrane-coated nanothylakoid–ceria system coupling ATP/NADPH generation with redox buffering. In aged mice, CM-NTU-Ce improved mitochondrial fitness, restored ATP/ADP and NADPH/NADP ratios, enhanced myogenesis and functional recovery. Mechanistically, CM-NTU-Ce remodeled macrophages; depletion reduced regeneration, while CM-NTU-Ce-conditioned macrophages supported myoblast differentiation. Metabolomics confirmed restoration of mitochondrial and redox pathways. These findings identify a recoverable constraint limiting aged muscle repair.</p>","dates":{"publication":"2026-08-13","submission":"2026-08-13"},"accession":"MTBLS15312","cross_references":{"HMDB":["HMDB0000086","HMDB0000641","HMDB0000965","HMDB0000875","HMDB0028922","HMDB0000296","HMDB0000112","HMDB0000162","HMDB0000163","HMDB0000123","HMDB0000062","HMDB0000161","HMDB0002024","HMDB0000158","HMDB0033453","HMDB0246950","HMDB0000172","HMDB0000133","HMDB0011179","HMDB0000089","HMDB0028988","HMDB0028911","HMDB0028932","HMDB0000479","HMDB0004620","HMDB0004437","HMDB0000883","HMDB0033951","HMDB0002366","HMDB0000195","HMDB0029133","HMDB0029130","HMDB0000252","HMDB0000975","HMDB0002141","HMDB0240650","HMDB0000716","HMDB0000159","HMDB0000897","HMDB0032538","HMDB0001173","HMDB0004949","HMDB0039531","HMDB0000301","HMDB0028702","HMDB0000194","HMDB0000552","HMDB0003464","HMDB0000064","HMDB0013127","HMDB0000824","HMDB0000043","HMDB0004827","HMDB0030396","HMDB0006038","HMDB0242132","HMDB0000050","HMDB0000593","HMDB0004950","HMDB0000271","HMDB0062203","HMDB0304396","HMDB0001325","HMDB0000224","HMDB0002820","HMDB0002013","HMDB0001522","HMDB0029134","HMDB0061712","HMDB0062559","HMDB0000157","HMDB0007982","HMDB0004193","HMDB0004948","HMDB0000736","HMDB0004194","HMDB0000052","HMDB0001586","HMDB0028813","HMDB0011178","HMDB0012881","HMDB0000092","HMDB0060741","HMDB0003584","HMDB0240288","HMDB0013128","HMDB0000982","HMDB0029140","HMDB0000562","HMDB0000660","HMDB0000688","HMDB0002038","HMDB0000095","HMDB0001413","HMDB0000719","HMDB0029010","HMDB0031641","HMDB0251473","HMDB0029007","HMDB0000269","HMDB0001934","HMDB0061822","HMDB0001406","HMDB0059873","HMDB0032150","HMDB0030540","HMDB0032148","HMDB0251526","HMDB0001565","HMDB0003540","HMDB0000045","HMDB0061694","HMDB0000756","HMDB0240609","HMDB0256256","HMDB0004971","HMDB0094708","HMDB0244507","HMDB0000258","HMDB0000167","HMDB0001185","HMDB0000904","HMDB0000201","HMDB0011506","HMDB0012108","HMDB0041922","HMDB0013243","HMDB0246162","HMDB0000564","HMDB0001563","HMDB0001262","HMDB0000939","HMDB0010390","HMDB0010407","HMDB0000323","HMDB0001538","HMDB0000048","HMDB0000182","HMDB0028881","HMDB0000097","HMDB0000791","HMDB0000244","HMDB0007972","HMDB0000187","HMDB0094696","HMDB0000214","HMDB0249241","HMDB0006455","HMDB0000222","HMDB0015101","HMDB0001257","HMDB0240585","HMDB0000651","HMDB0013337","HMDB0000895","HMDB0002250","HMDB0005066","HMDB0005862","HMDB0000699","HMDB0010386","HMDB0007866","HMDB0007869","HMDB0062769","HMDB0001539","HMDB0250707","HMDB0000517","HMDB0000235","HMDB0000898","HMDB0028716","HMDB0008097","HMDB0000630","HMDB0000855","HMDB0059712","HMDB0000039","HMDB0001861","HMDB0003243","HMDB0245025","HMDB0000870","HMDB0010382","HMDB0008031","HMDB0008994","HMDB0259112","HMDB0003282","HMDB0301753","HMDB0003269","HMDB0244070","HMDB0000197","HMDB0032055","HMDB0010384","HMDB0008034","HMDB0007970","HMDB0000819","HMDB0001097","HMDB0253025","HMDB0014984","HMDB0004350","HMDB0006050","HMDB0255618","HMDB0000034","HMDB0254682","HMDB0015504","HMDB0029412","HMDB0030372","HMDB0012101","HMDB0006469","HMDB0011262","HMDB0011253","HMDB0014789","HMDB0015334","HMDB0248007","HMDB0007881","HMDB0012265","HMDB0245026","HMDB0029874","HMDB0029426","HMDB0304810","HMDB0029322","HMDB0029004","HMDB0028995","HMDB0244929","HMDB0029005","HMDB0242151","HMDB0007965","HMDB0254880","HMDB0008206","HMDB0256963","HMDB0243891","HMDB0245006","HMDB0039528","HMDB0246417","HMDB0245482","HMDB0041253","HMDB0304156","HMDB0242212","HMDB0252111","HMDB0034301","HMDB0062295","HMDB0029586","HMDB0002815","HMDB0011152","HMDB0032358","HMDB0241377","HMDB0013329","HMDB0006317","HMDB0011206","HMDB0254922","HMDB0033247","HMDB0028878","HMDB0011174","HMDB0009399","HMDB0040030","HMDB0253663","HMDB0008002","HMDB0259297","HMDB0009093","HMDB0008748","HMDB0253644","HMDB0012296","HMDB0040646","HMDB0011730","HMDB0032698","HMDB0094680","HMDB0240664","HMDB0240261","HMDB0240606","HMDB0013288","HMDB0011352","HMDB0240766","HMDB0240750","HMDB0007921","HMDB0029416","HMDB0028950","HMDB0028705","HMDB0028718","HMDB0028719","HMDB0028722","HMDB0010398","HMDB0010405","HMDB0012107","HMDB0258887","HMDB0243828","HMDB0008923","HMDB0008443","HMDB0244804","HMDB0032137","HMDB0037167","HMDB0040356","HMDB0041326","HMDB0040439","HMDB0029795","HMDB0029217","HMDB0032323","HMDB0013238","HMDB0241768","HMDB0241313","HMDB0007890","HMDB0032231","HMDB0341191","HMDB0060840","HMDB0062376","HMDB0002095","HMDB0254305","HMDB0257158","HMDB0002065","HMDB0013336","HMDB0031710","HMDB0014494","HMDB0013409","HMDB0014944","HMDB0042061","HMDB0034198","HMDB0241562","HMDB0013161","HMDB0001564","HMDB0028888","HMDB0011180","HMDB0038321","HMDB0035143","HMDB0038279","HMDB0029569","HMDB0061690","HMDB0242112","HMDB0245731","HMDB0028884","HMDB0028790","HMDB0248974","HMDB0010720","HMDB0014878","HMDB0252014","HMDB0015554","HMDB0014382","HMDB0030180","HMDB0033691","HMDB0037104","HMDB0011523","HMDB0241447","HMDB0241367","HMDB0028692","HMDB0028709","HMDB0028946","HMDB0034927","HMDB0029888","HMDB0015573","HMDB0245506","HMDB0252929","HMDB0062375","HMDB0041363","HMDB0029030"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