MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/m_MTBLS15360_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/m_MTBLS15360_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/a_MTBLS15360_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/a_MTBLS15360_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/s_MTBLS15360.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/A-2_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/B-3_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/A-3_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/B-2_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/B-1_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/A-1_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/A-2_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/A-1_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/A-3_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/B-3_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/B-1_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360/FILES/DERIVED_FILES/B-2_P.mzMLprimary200OKftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15360<p>Metabolite identification was carried out relying on the self-built Metware Database (MWDB) via secondary mass spectrum data. Isotope signals, redundant signals containing K+, Na+ and NH4+ adduct ions, as well as fragment ion signals originating from higher-molecular-weight compounds were eliminated during analysis.</p><p><br></p><p>Metabolite quantification was completed under the multiple reaction monitoring (MRM) mode of triple quadrupole mass spectrometry. Under MRM mode, the quadrupole firstly screens precursor ions of target substances to preliminarily exclude ions of other molecular weights. After collision-induced dissociation in the collision cell, the precursor ions break into numerous fragment ions. A characteristic fragment ion is then selected through triple quadrupole filtration to eliminate interference from non-target ions, achieving higher accuracy and reproducibility for quantification.</p><p><br></p><p>After acquiring mass spectrometry data of metabolites from all samples, chromatographic peak area integration was conducted for all substances, and integration calibration was performed on peaks of the identical metabolite detected across different samples (Fraga et al., 2010).</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p _msttexthash='6575188555' _msthash='654'>Chromatographic separation was performed on an Agilent SB-C18 column (1.8 μm particle size, 2.1 mm × 100 mm). The mobile phase consisted of solvent A (ultrapure water containing 0.1% formic acid) and solvent B (acetonitrile containing 0.1% formic acid). The linear elution gradient was set as follows: 5% solvent B at 0.00 min, increased linearly to 95% solvent B within 9.00 min and held constant for 1 min; from 10.00 min to 11.10 min, the proportion of solvent B was decreased to 5%, and the system was equilibrated at 5% solvent B until 14 min. The flow rate was 0.35 mL/min, the column temperature was maintained at 40 °C, and the injection volume was 2 μL.</p>Metabolic Remodeling of Soil Ecosystems by the medicinal fungus Wolfiporia cocos: Bidirectional Feedback and Functional Consequences.Huazhong Agricultural UniversityLongfei Xueinner partsurface layermass spectrometry assay<p _msttexthash='3217362603' _msthash='582'>The biological samples were vacuum freeze-dried in a Scientz-100F lyophilizer for 63 hours. The dried samples were ground into fine powder using a Retsch MM 400 grinder at 30 Hz for 1.5 minutes. Subsequently, 30 mg of sample powder was accurately weighed using an MS105DM electronic balance and extracted with 1500 μL of pre-cooled (−20 °C) 70% methanol aqueous solution containing internal standard. For samples weighing less than 30 mg, the extraction solution was added proportionally at 1500 μL per 30 mg sample. The internal standard solution was prepared by dissolving 1 mg of standard substance in 1 mL of 70% methanol water to prepare a 1000 μg/mL stock solution, which was further diluted with 70% methanol water to obtain a 250 μg/mL working internal standard solution. The mixture was vortexed for 30 seconds every 30 minutes, repeated six times in total. After centrifugation at 12000 rpm for 3 minutes, the supernatant was collected and filtered through a 0.22 μm microporous membrane. The filtrate was transferred into injection vials for subsequent UPLC-MS/MS metabolomic analysis.</p>Wolfiporia cocoshttps://www.ebi.ac.uk/metabolights/MTBLS15360Longfei Xue. Huazhong Agricultural University. 2971294521@qq.com.<p>Raw MS spectral data were acquired using Analyst 1.6.3 software. Metabolite peak identification, peak alignment, baseline correction, and peak area integration were performed using MultiQuant software. Missing values were filled with one-fifth of the minimum value of each metabolite. Quality control (QC) filtering was conducted by retaining metabolites with CV values less than 0.5. Subsequent statistical analyses, including principal component analysis (PCA), orthogonal partial least squares discriminant analysis (OPLS-DA), differential metabolite screening, clustering analysis and functional enrichment analysis, were implemented using R programming language.</p>Organism part2971294521@qq.com<p _msttexthash='3217362603' _msthash='525'><strong>Wolfiporia cocos</strong> sclerotium samples were collected from three independent cultivation sites in Huanggang City, Hubei Province, China, including Jiuzihe Town (30°35′ N, 115°06′ E) and Muzidian Town (31°13′ N, 115°24′ E) of Macheng City. The field cultivation experiment was carried out from mid-May to mid-November 2024, and the three sampling sites exhibited distinct topographical conditions. For each harvested sclerotium, two typical tissue parts were manually separated for widely targeted metabolomic analysis: the surface layer (Scl.sl, <strong>Wolfiporia cocos</strong> peel) and the inner part (Scl.ip, inner <strong>Wolfiporia cocos</strong> tissue). All tissue samples were freshly collected, cleaned to remove surface impurities, and immediately frozen in liquid nitrogen, followed by freeze-drying and low-temperature preservation for subsequent metabolite extraction and UPLC-MS/MS detection.</p>Metabolomicsinner partultra-performance liquid chromatography-mass spectrometryExionLC™ AD UHPLC system (SCIEX)MetabolomicsnormalProteoWizard msconverttargeted analysissurface layerSCIEX QTRAP triple quadrupole mass spectrometerUPLC tandem mass spectrometryWolfiporia cocosexperimental sampleinner partultra-performance liquid chromatography-mass spectrometryExionLC™ AD UHPLC system (SCIEX)MetabolomicsnormalProteoWizard msconverttargeted analysissurface layerSCIEX QTRAP triple quadrupole mass spectrometerUPLC tandem mass spectrometryWolfiporia cocosexperimental sample<p _msttexthash='32273813' _msthash='731'>The electrospray ionization (ESI) source temperature was set to 500 °C. The ion spray voltage (IS) was 5500 V for positive ion mode and −4500 V for negative ion mode. The ion source gas I (GSI), gas II (GSII), and curtain gas (CUR) were set at 50 psi, 60 psi, and 25 psi, respectively, with high collision-induced dissociation parameters. Triple quadrupole (QQQ) scanning was performed in multiple reaction monitoring (MRM) mode, and nitrogen was used as the collision gas at a medium level. The declustering potential (DP) and collision energy (CE) were optimized for each MRM ion pair. Characteristic MRM ion pairs were monitored dynamically according to the elution characteristics of metabolites at different chromatographic stages.</p>Vincamine*(2E,4S,5R)-5-hydroxy-4-methylhept-2-enoic acid(2S,5S)-trans-CarboxymethylprolineOroxin A2',4'-Dihydroxyacetophenone*Phe-IleLys-Asp*CoumestrolProlylproline2,4,4'-trihydroxychalcone*(E)-endo-beta-bergamotenoic acid4,7,22,24-Tetrahydroxy-3,4-Seco-11,13(18)-Oleanadien-3-Oic AcidPantothenolL-HistidineQuercetin-3-O-neohesperidoside*3,4-Dehydro-DL-proline3-Hydroxy-1-methoxy-9,10-anthraquinone2,2,4-trimethyl-5-oxocyclohex-3-ene-1-carboxylic acid*LPC(18:1/0:0)linoleoyl ethanolamine15-Hydroxy-3-Oxolanosta-7,9(11),24-Trien-26-alLysoPC 18:1*Poricoic acid CM*3-Oxopomolic acid*2,3-Dihydroxy-23-Oxo-12-Ursen-28-Oic AcidIsomeranzinIsothankunic acidN-Methylisoleucine7-Deazainosine(2-Oxo-5-methoxyindoline-1-yl)carbamic acid methyl ester1-Oleoyl-Sn-GlycerolLysoPE 17:1(2n isomer)*3'-Methoxydaidzein*Isoguanine(6-amino-3-oxohexan-2-yl)prolineNG,NG-Dimethyl-L-arginine*5-O-Methylvisammiosidep-coumaroyl l-arabinose*TetrahydrofolateIlexolide A1,3-Dihydroxyurs-12-en-28-oic acid (Kaneric acid)N6-Acetyl-L-lysineHordenine4-Methylene-L-glutamineAspergilol C*5-Hydroxymethyl-2-furaldehydeMethylillicinone F*ÎÛ-Glu-LeuGanoderenic Acid AM1Gly-Ala-HisBis(2-ethylhexyl)phthalate*3,4,9-TrihydroxypterocarpanLupane-20(29)-en-3-on-28-oic acid2-amino-5-[(C-hydroxycarbonimidoyl)amino]pentanimidic acid2-Aminotetradecane-1,5,13-triol15-Hydroxy-3-oxolanosta-7,9(11),24-trien-26-oic acid (Ganoderic Acid TR)5alpha-Oleana-11,13(18)-dien-3-oneHemileptaglinAla-Lys-Leu3-Pyrrolidine carboxylic acid*L-Valyl-L-Leucine(3r,3ar,5ar,5br,7as,11as,13as,13br)-3-isopropyl-3a,5a,8,8,11a,13a-hexamethyl-1h,2h,3h,4h,5h,5bh,6h,7h,7ah,9h,10h,11h,13bh-cyclopenta[a]chrysen-13-one2-HydroxymethylanthraquinoneOxyphyllol A*N5-(4-Methoxybenzyl)glutamineLidocaineCelastrol; Tripterine*2-AminoicoSane-1,5,19-triol3-amino-4-methyloxetan-2-one*3,16-Dihydroxy-24-methylenelanosta-7,9(11)-dien-21-oic acid*o-PhosphohomoserineHydroxythreonine xylosideL-OrnithineLysoPC 16:2*Adenosine N1-oxide*(6S)-2-methyl-6-(4-methylcyclohexa-2,5-dien-1-yl)hept-2-en-4-oneSuccinyladenosine1,3(15),10-Bisabolatrien-12-al2-FormaminobenzoylacetateIsoshonanin*LysoPE 17:1*Gallocatechin 3'-O-gallate*LysoPC 19:115Ï«-Hydroxydehydrotumulosic acidcis-MoschamineOctadec-8-enamide*Indole-4-Carboxaldehyde*Pterohoonoid CNorarjunolic acidPerenniporiol*Methylguanidine2,6-diamino-7-methyl-5-oxooctanoic acidEnt-14,15-Dinor-3-Cleroden-3-one*(3R)-3-[(2R)-1,2-dihydroxypropan-2-yl]-6,10-dimethylspiro[4.5]deca-6,9-dien-8-oneSenkyunolide C*1-Octadecanoyl-sn-glycero-3-phosphoethanolamine5-Aminonicotinic acidtrans-2-Butene-1,4-dicarboxylic AcidRocagloic acidp-Methoxycinnamaldehyde2-aminodocoSane-1,6,19,20,21-pentaol4-(1,2-Dihydroxypropan-2-yl)cyclohex-1-ene-1-carboxylic acidOctadeca-11E,13E,15Z-trienoic acidBenzamide11-Hydroxy-5,15-Rosadien-7-OneAsp-GluHyperin*1-(hydroxymethyl)-1,4,7-trimethyl-2,5,6,7,7a,7b-hexahydro-1aH-cyclopropa[e]azulen-3-oneL-Azetidine 2-carboxylic acid*L-CarnitineSubernon2-Aminotetradecane-1,11,13-triolMet-ThrArnebinolAminoimidazole ribotideTubiferic Acid*1,5-Anhydro-D-fructoseN-Acetyl-D-mannosamineQuercetin-5-O-ÉÇ-D-glucoside*ÉÇ-Mangostin(2-aminoethoxy)[2-hydroxy-3-(octadeca-9,12,15-trienoyloxy)propoxy]phosphinic acid*D-2-AminobutyrateLysoPC 20:2(2n isomer)serrat-14-ene-3,21,24,29-tetrolAlertenoneGuanine*Gly-Arg-Met5-Oxo-D-proline13(S)-Hydroxyoctadeca-9(Z),11(E)-dienoic acid (13-HODE)Stagonolide FIsomasticadienolalic acid*Rutin*L-Leucyl-L-Leucine3-Methylsubericacid6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8H-purin-2-one*Sorbinol B*L-PhenylalanineAcetryptine5-MethylcytosineDataset-S1.246(8beta)-Fern-9(11)-en-7-oneHumula-3(12),7(13),9(E)-triene-2,6-diol3-(Acetyloxy)-16-hydroxy-24-methylenelanosta-7,9(11)-dien-21-oic acid (Dehydropachymic acid)N-Acetyl-D-galactosamine28-Hydroxy-20(29)-Lupene-3,7-dione3-Hydroxy-16-O-Acetyl-dehydrotrametenolic acid*isovalineSphingosineCelastrol*Buddledin C*3-p-Coumaroyloxy-2-hydroxyurs-12,18-dien-28-oic acid (Guajavanoic acid)LysoPC 17:1Ganoderenic Acid A24,25-Epoxydammar-20-En-3-olLysoPC 17:2S-Methyl-methionine*Gibberellin A5Thr-Lys2,3-Dihydroxy-12,20(30)-Ursadien-28-Oic Acid*Acetyl Resveratroldelta-Guanidinovaleric acidL-Cystathionine2-Aminohexadecane-1,5,15-triol2,7-dihydroxy-8-methylphenanthrene-4-carbaldehyde2-Aminotetradecan-1-ol*iso-Iridotectoral A(S)-2-Phenyloxirane*2-Norbornaneacetic acidCeriopsin B24-HydroxyecdysoneSuccinic anhydride12,15-dioxo-selina-4,11-dineLys-Asn3-Hydroxyolean-12-en-29-oic acid (Epikatonic acid)Ganolucidic Acid DFuranoeremophilane*N(omega)-Methyl-L-arginine*LupenoneLysoPC 15:13,22-Dihydroxy-12-Pachanen-28,14-olideHumantenine*Estrane-3,17-diol(3Ar,6R,9E,12Ar)-3A,6,10-Trimethyl-1-Propan-2-Ylidene-3,5,6,7,8,11,12,12A-Octahydro-2H-Cyclopenta[11]Annulen-4-oneD-Threose3,7,15-Trihydroxy-11,23-dioxolanost-8-en-26-oic acid (Ganoderic Acid C2)Gelliusterol DLysoPC 16:1*Ala-Ala-ValN-(ÎÛ-Glutamyl)ethanolamine4,5-Dehydro-L-leucine*(1S,2R)-4-(hydroxymethyl)-3,5,5-trimethylcyclohex-3-ene-1,2-diolGanoderic Acid Sigma2'-Hydroxygenistein*Norophthalamic acid7-Oxodehydroabietic acidN-Isobutyl Decanamide4,7a-dimethyl-2-methylidene-2a,3,3a,5,6,7,8,8a-octahydro-1H-cyclobuta[g]naphthalene-1,4-diolGelsemamidePoricoic acid BM14,15-Dehydrocrepenynic acid(4aR,6aR,6bS,8aS,14aR,14bS)-8a-(hydroxymethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-hexadecahydropicen-3(2H)-one5-guanidino-2-(2-hydroxyethyl)pentanoic acidIndole-3-carboxaldehyde3-Acetoxy-15-hydroxylanosta-7,9(11),24-trien-26-oic acid (Ganoderic Acid Mf)*5-Aminopentanoate4,5,5-Trimethyl-2-Oxo-3-Cyclohexene-1-Carboxylic Acid*2-benzoyl-4-[(2r)-1-hydroxy-7-methyl-3-methylideneoct-6-en-1-yl]benzene-1,3,5-triolPoricoic acid AMGanoderic Acid XiÎÛ-Glu-Phe*Octadeca-9,12,15-trienoic acid*Dehydroeburicoic acidCinnamoylglycinePG(16:1(9Z)/0:0)Ursolic acid*neonootkatolPhosphatidylcholine lyso 18:1*Diisobutyl phthalate*(2-{[(2S)-2,3-dihydroxypropyl phosphonato]oxy}ethyl)trimethylazaniumLysoPE 17:0Lys-TyrLysoPE 15:0*L-Glutamate1-Aminopropan-2-ol*CafestolGenistein5-MethoxyindoleacetatePseudoindorinGly-Val-AlaProtochiisanogeninalisol U2-(hydroxymethyl)-5-{4-imino-3h-furo[3,2-d]pyrimidin-7-yl}oxolane-3,4-diolMenatetrenone (Vitamin K2)Isorauhimbine*LysoPE 18:1(2n isomer)*L-Isoleucine*2-Amino-4,5-dihydro-1H-imidazole-4-acetic acidLysoPE 18:2(2n isomer)9-Arabinosyladenine*N-Heptanoyl nornicotine1-cyclohex-2-en-1-yl-1-phenylethanol5,7,3',4',5'-pentahydroxyflavan glucosidePyrrolidin2-isopropyl-3,4,8,9-tetramethyl-5-methylenecyclodeca-3,8-dien-1-ol*3-Hydroxy-L-phenylalanine*3ÉÇ,21ÉÇ,24-trihydroxy-16-oxoserrat-14-en-29-methyl ester3,5-Dimethyl-2,3-dihydrobenzofuran3',7-dihydroxy-4'-methoxyflavone*Claussequinone1,3,8-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione*3,16-Dihydroxylanosta-7,24-dien-21-oic acid Gamma-lactone (Kulolactone)4-AminobutanoateC16 phytosphingosineN(6),N(6)-Dimethyl-L-lysineBelamcandal9-Oxo-10,12-Octadecadienoic AcidAlisol IAlisol F3,22-Diacetyloxy-lanosta-7,9(11),24-trien-26-oic acid (Ganoderic Acid R)3',4',7-TrihydroxyflavoneGlochidolFurfuryl acetate4-Amino-6-hydroxypyrazolo[3,4-d]pyrimidine*Methyl 4,5-dihydroxy-6-(2-hydroxyethyl)-8-methoxy-9-oxoxanthene-1-carboxylatenaphthisoxazol A*Cinnamoyltyraminecis-10-Nonadecenoic acid3-Hydroxyurs-12,19-dien-28-oic acid (Sanguisorbigenin)19-Hydroxy-2-(hydroxymethyl)-A(1)-norursa-2,12-dien-28-oic acid (Coleonolic acid)3-Hydroxy-urs-11-en-28,13-lactoneEmericolin C*N5-Ethyl-L-glutamineGly-Pro-GlyGln-GlyRetronecineAgmatineLys-Tyr-GlyBaimantuoluoside C2-aminodocoSane-1,5,7,21-tetraol3,25-Epoxy-3-hydroxyurs-12-en-28-oic acid (Lantic acid)PyridoxalDehydroisoactinidic Acid22,23-DihydronimonolN-Acetyl-D-glucosamineEnt-15,16,18-Trihydroxy-7-Pimaren-3-oneLysoPC 19:2(2n isomer)Butyl isobutyl phthalate*2-PyrimidinemethanamineZarzissine2-[(1-methyl-1H-indol-4-yl)formamido]propanoic acid3-Oxolanosta-7,9(11),24-trien-26-oic acid (Ganoderic Acid S)Prolylglutamic acid1-Hydroxy-3-oxoolean-12-en-30-oic acid4-Fumarylacetoacetic acid4-(2-aminoethenyl)phenol*AICA ribonucleotide4-Hydroxy-L-IsoleucineSpathulenol*Abiesatrine H2-methyloxolane-2,3,4-triolLysoPE 20:4*20-Taraxastene-3,12,16-Triol1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,8a,10a-octahydrophenanthrene-1-carbaldehyde*Mudanpinoic acid AResokaempherol3ÉÇ,14Ï«,15Ï«,21ÉÇ-tetrahydroxyserratane-24-oic acidOctadec-2-enamide*(3r)-4,5-dihydro-3h-pyrrole-2,3-diol*9alpha-hydroxy-androst-4-ene-3,17-dione4',5,7-Trihydroxy-3',6-dimethoxyflavone (Jaceosidin)*DopamineTamarixetinPicfeltarraegenin IIIGly-Glu-Asp(2E,4E)-9-hydroxy-N-(2-methylpropyl)nona-2,4-dienamide10,14-Cyclo-3-Hydroxy-ÉÇ-Santal-11(13)-En-12-alCholesterolGlycyl-phenylalaninePantothenate3ÉÇ,11-Dihydroxy-4,14-oxideenantiocudesmaneSer-ArgTricin-7-O-(6''-O-acetyl)glucosideLeukotriene B4Oleanolic aldehyde(2R,6R)-piperidine-2,6-dicarboxylic acidTatarineDibutyl sebacateTyr-Ala(2Z,5R,6E,10R)-3-(hydroxymethyl)-7,11-dimethyldodeca-2,6,11-triene-1,5,10-triolL-ValineVidarabine27,28-Dicarboxyl ursolic acid(2S,4R)-1,4-dimethylpyrrolidine-2-carboxylic acid*ʽ-hydroxyquinoline*N5-(1-Iminoethyl)-L-ornithineMethyl OrsellinateTryptamineLeu-Ala-GlnUNPD60671,3-dihydroxy-2,3,3a,4-tetrahydropyrrolo[2,1-b]quinazolin-9(1H)-oneNootkatone*15-Acetyloxy-3-hydroxylanosta-7,9(11),24-trien-26-oic acid (Ganoderic Acid X)3-ChloroanilineTumulosic acidTricinDL-isoleucyl-DL-isoleucyl-DL-isoleucineVersisponic Acid D*Fumotoshidin A16-oxo-11-anhydroalisol ACytosineAphagraone ALaurocapram3-Hydroxylup-20(29)-en-28-al (Betulinaldehyde)16R-Sitsirikine*3-O-Glucoside-3-hydroxy-y-butyrolactone3-Hydroxyolean-12-ene-27,28-dioic acid (Cincholic acid)Barbituratecis-3-Hydroxy-L-proline*3-MethyleneindolenineLysoPE 18:3(2n isomer)4,4,6A,6B,8A,11,12,14B-Octamethyl-5,14-Dioxo-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,14,14A,14B-Icosahydropicen-3-Yl AcetateEuphoroyleans H2-amino-7-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one*3-[4-(2-Hydroxypropan-2-Yl)Phenyl]-2-OxopropanalDehydrotumulosic Acid*3,15-Dihydroxylanostane-7,9(11),24-trien-26-oic acid (Ganoderic Acid Jb)2,3-Dihydrobenzofuran*Pro-Asn-MetBis(2-ethyl-hexyl)-phthalateApigenin-7-O-glucuronide*IsoglutamineIndole-3-acetateLuteolin-7-O-rutinoside*Met-Asn2-Acetyl-3-ethylpyrazine(-)-EpicatechindibutylamineHydroxycarvoneL-HomocystineIsomacedonic AcidEthyl 3-hydroxybutyrateSer-Asp-SerAvicennol*(R)-3-ethyl-7-hydroxy-6-methoxyphthalide15-Methoxy-8(17)-Labden-19-Oic Acid4-Hydroxy-l-tryptophan(1R,7S)-1,12,13-trihydroxybisabola-3,10-dieneLysoPE 16:0(2n isomer)4-[(1S,4aR,5R,8aR)-5-hydroxy-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]-2-methylidenebutanalL-Proline*dAMPSenkyunolide Q*Myricatomentogenin21,23:24,25-Diepoxylanost-7-ene-3,21-diol 3-acetate (Melianol)3-(1H-imidazol-5-yl)-2-(trimethylammonio)propanoateDiisooctyl phthalate*Tyr-Leu3-O-Acetyl-16-hydroxy-dehydrotrametenolic acid3-hydroxylup-12(13),20(29)-dieneLysoPC 20:4N-Acetyl-L-phenylalanineLysoPC 20:2JasminodiolAzoxystrobin acidN-Benzylformamide*Abbeokutone(5S,6R)-5-methyl-6-(3-oxobutyl)cyclohept-2-en-1-one2-Aminohexadecane-1,4-diolGanoderic Acid GammaHexadecylsphingosine3,4',5,6,7-PentamethoxyflavoneL-Citrulline3-(3',5'-Dimethoxy-4'-hydroxy-benzylidene')-2-indolinoneKaempferol-3-O-neohesperidoside*5,6-DHETPro-Val-TyrH-Asp(Leu-OH)-OHHis-Cys-Asp5,8-dimethoxy-3-methylnaphthalen-1-ol3-Hydroxylup-12(13),20(29)-diene-28-oic acidLys-Thr-Thr1-Aminocyclopropane-1-carboxylateSchisanlactone E3,7,11-trimethyl-2-oxa-6,10,13-triazatricyclo[7.3.1.05,13]tridecane8-(5-Hydroxy-2,6,6-Trimethylcyclohex-2-En-1-Yl)-6-Methyloct-5-En-2-one1-MonomyristinAdenosine*Fern 9(11)-en-12-oneLeu-Val-Lys(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 2,4,6-trihydroxybenzoateLysoPC 17:0(2n isomer)*Agallochol CScutebarbolide C*Methyl acetoxy-[6]-gingerol2-Aminohexadecanoic acidQuercetin-3-O-(2''-O-rhamnosyl)galactoside3',5',5,7-Tetrahydroxy-4'-methoxyflavanone-3'-O-glucoside4-methoxybenzamide3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid (Pachymic acid)*Tricin-4'-O-glycerolApigenin 7-O-[beta-D-apiosyl-(1->2)-beta-D-glucoside]gamma-Glutamylglutamine3,23-Dihydroxy-7,11,15-Trioxolanosta-8,24-Dien-26-Oic AcidGossypetin-3-O-glucoside*O-AcetylcarnitineKaempferol-3-O-glucoside-7-O-rhamnoside*3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid methyl ester (Pachymic acid methyl ester)9-Oxooctadeca-10,12-Dienoic AcidL-GlutamineD-GlucosamineCholineLysoPC 18:1(2n isomer)*N-Octanoyl-nornicotine2-Amino-7-methyltridecan-1-ol*Xylariterpenoid GHomoprolineAsn-Cys(3-(carboxyamino)-2-methylpropanoyl)phenylalanine*5-Methoxy-1,7-diphenyl-3-heptanone2-hydroxymethyl-D-ribono-ÎÛ-lactonep-Coumaroyl-arabinofuranose*3,25-Epoxy-3-hydroxyolean-12-en-28-oic acid (Lantanolic acid)Homomethionine*N-(3-hydroxy-4-methoxyphenethyl)-4-hydroxybutanamide24-Nor-3,12-Ursadien-11-one11,12-epoxy-13-hydroxy-3-Oxooleanane-28-oic acid gamma-lactone (Liquidambaric Lactone)(3E)-3-hexadecylidene-4,5-dihydroxy-5-methyloxolan-2-oneGymnasterone C7-phenylhept-2-en-1-ol2,3,14,20,22-Pentahydroxycholesta-7,9(11)-diene-6-one (Dacryhainansterone)Asn-ArgIndoline5-(2-aminoethyl)-8-hydroxyquinolin-2(1H)-oneVitetrifolin H2-Hydroxymethyl-A(1)-nor-19,24-dihydroxyurs-2,12-dien-28-oic acid (Rosamultic acid)*isoincensole3,29-Dihydroxyolean-12-en-28-oic acid (Mesembryanthemoidigenic acid)*N,N-Dimethylglycine*Tupichinin A3-(triazan-2-yl)propyl L-prolinate5-hydroxy-1-(3,4-Dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-3-heptanoneCholine phosphate13,28-Epoxyolean-11-en-3-oneBetulin3,11-Dioxo-19-hydroxyurs-12-en-28-oic acid*2-Aminopurine(+)-(1S,2S)-PseudoephedrineHyp-SerL-IsoserineHolstinone CIMP5-Hydroxy-3,7-dimethoxy-1,4-phenanthrenequinoneGlu-SerRiboflavolPro-AsnPro-AspMethyldopa anhydrousN6,N6-DimethyladenosineCaffeoyl 1-deoxy-2-pentulose(2Z)-6-hydroxy-2-(3-methoxybenzylidene)-1-benzofuran-3(2H)-one2,6,6-trimethyl-4-oxo-2-cyclohexen-1-carbaldehydeLys-Thr-PheL-Homocysteine2-aminotetracoSane-1,5,23-triolLysoPC 16:1(2n isomer)*3,23-Dioxolanosta-7,24-Dien-26-Oic AcidCDP-cholinegnetupendin A1-(2-(pyridin-3-yl)-2,3-dihydro-1H-pyrrol-1-yl)propan-1-one4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acidPhe-Hyp6-Deoxyfagomine2,3-Dihydroxylup-20(29)-en-28-oic acid2-(3,4-dihydroxyphenyl)-2H-chromene-3,5,7-triol2-(2-Ethynyl-2,4-cyclopentadien-1-ylidene)ethenolGanoderenic acid DPiperidine2',4'-DimethylacetophenoneGanoderenic acid F2-methyl-1-nitronaphthalene3,5,3',4',5'-penta-hydroxyflavan-7-gallate*Asn-Cys-AlaSandaracopimarinalIsocytosine2-Aminododecane-1,4-diolOctadeca-2,9,12,15-tetraen-1-olMonopalmitin*omega-AminoarginineN-Methyl-Trans-4-Hydroxy-L-Prolineent-Labda-8(20),12Z,14-triene-2alpha,3beta-diol3-Hydroxy-11-oxours-12-en-28-oic acid (11-Keto-ursolic acid)*(3E,7E)-4-Methyl-2,5,6,9-Tetrahydrooxecin-10-oneLysoPE 18:0(2n isomer)L-Isoleucyl-L-AspartateL-Alanyl-L-Phenylalaninepreisocalamenediol*Rubitic Acid(2R,5S)-2,5-Diaminohexanoate3'-Hydroxy-3,4,5-trimethoxybibenzylL-Aspartyl-L-Phenylalanine4(18),15-Erythroxyladien-3-one*Betaine*Riboflavin7-Ethenyl-1-(Hydroxymethyl)-1,4a,7-Trimethyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-Dodecahydrophenanthren-2-one(R)-2-hydroperoxy-alpha-linolenic acid2-Methylpyrrolidine-2-carboxylic acid*N-FeruloylserotoninMaytensifolone2-acetamido-3-(1H-imidazol-4-yl)propanoic acidQuinolineBenzylacetone4-GuanidinobutanoateLysoPC 15:0(2n isomer)*Mesendanin ONicotinate D-ribonucleosideMyricetin-3-O-galactoside*3Ï«,21ÉÇ,29-trihydroxy-serrat-14-en-16-oneTetradecasphinganineVal-TrpserratenediolFlavoneO-Acetyl-L-serineSpongouridineGMP8-pdc-benzoyldeoxyaconinetrichobisabolin c1-(hydroxymethyl)-1,4a-dimethyl-7-propan-2-ylidene-2,3,4,4b,5,6,10,10a-octahydrophenanthren-9-onemethyl piperidine-2-carboxylate*2-Phenylacetamide*GuvacolineLeu-AspHercynine2-AminodocoSane-1,5,21-triol24-Hydroxy-3-oxooleana-11,13(18)-dien-28-oic acid11-Hydroxycubebol*Phenylethyl alcoholTributyl citrate2-Ethynyl-5-methoxybenzo-1,4-quinoneEpigoitrin5-Hydroxy-2-pyrrolidinoneAsp-Asn-Ile4,5,6-Trihydroxy-2-cyclohexen-1-ylideneacetonitrile(2R)-2-azaniumyl-3-(4-chlorophenyl)propanoateGorlic acid*L-Asparagine2-benzoyl-4-[(2r)-2-hydroxy-7-methyl-3-methylideneoct-6-en-1-yl]benzene-1,3,5-triol3-epi-fagominePeganineAfricanone*9,10-Cyclo-P-Menth-1-En-4-olInoterpene F(1S,3R,3a1S,8R,10S,11aS)-1,5,10-trihydroxy-3,3a1,8,11a-tetramethyl-2,11-dioxohexadecahydrodibenzo[de,g]chromen-4-yl acetate*4-Hydroxy-ÉÇ-bulnesene2-Feruloyl-sn-glycerol2-Amino-2-methylpropanoate1,7-bis(4-hydroxypheny)hept-1-ene-3,5-diolN-Acetylcadaverine6,7-Dehydroporicoic acid H3-O-Methyl-a-methyldopa*Poricoic acid E2-[[3-Mercapto-2-(alpha-glutamylamino)-1-oxopropyl]amino]acetic acidPoricoic acid CCamellisin B2-amino-2-(1-methyl-1H-pyrazol-4-yl)acetic acid11-(Hydroxymethyl)-4,4A,6A,6B,8A,11,14A-Heptamethyl-2,4,5,6,6A,7,8,9,10,12,12A,13,14,14B-Tetradecahydro-1H-Picen-3-oneL-Norleucine*Cyclohexanondientriterpenic acid2-Oxo-3,4-dihydro-1H-quinoline-3-carboxylic acid1-MethyltryptophanLys-Met-AlaRobinetin3-Hydroxyolean-12-ene-28,29-dioic acid (Serratagenic Acid)*Alismol2-Aminotetradecane-1,4-diolLingzhine C16Ï«-Hydroxydehydrotrametenolic acid2-Aminohexadecane-1,16,16-triolPterocarpol*Ï«-kamlolenic acid3-Oxolanosta-8,22,24-Trien-26-alEuscaphic acid8-(Benzyloxy)-1-NaphtholPro-Asn-Gly16-Hydroxytrametenolic acid*6-Aminohexanoate8-Hydroxy-3,4-dihydro-2H-1-benzopyran-2-oneTributyl acetylcitrateN-methyl cis-4-hydroxymethyl-L-prolineLysoPC 17:0*3Ï«,20ÉÇ,21ÉÇ-trihydroxy-16-oxo-serrat-14-en-24-oic acidcis-Aconitate3-hydroxy-2-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}propyl hexadeca-7,10,13-trienoateNicosesquiterpene A1S,2R,5aR,7aS,7bR,13aS,14R)-14-hydroxy-1,2,5a,7a,7b,10,10,13a-octamethyl-2,3,6,7,7a,7b,8,9,9a,10,12,13,13a,13b,14,15b-hexadecahydrochryseno[2,1-b]oxepine-4,11(1H,5aH)-dione*3-O-Acetyl-16,26-dihydroxytrametenolic acid4-(1-Aminoethyl)phenol12-Hydroxyhydromethylabietate2-Aminohexadecane-1,5,6-triolUridine3-Oxo-12-Ursen-30-Oic Acid*LysoPC 16:2(2n isomer)*Glu-Phe3-Hydroxyurs-12-en-24-oic acid (ÉÇ-Boswellic acid)Krukovine ETomentodione F14-Amino-15-hydroxy-11-methylpentadecanoic acid2-(Dimethylamino)guanosine2-Aminooctadecane-1,5,17-triolRicogeninLeu Val Asp*L-Threonine*4-Hydroxy-4'-methoxydihydrochalcone3-Hydrocinnamyl-6-CinnamylGlucosePhenethylamineL-Homoserine*Ganoderic Acid B8GlutaminylcysteineHirtinoneMet-Met-Asp3,7,15,20-Tetrahydroxy-11,23-dioxolanost-8-en-26-oic acid (Ganoderic acid L)3-IndoleacetonitrileLysoPC 18:4LysoPC 18:3N6-Succinyladenosine3,4-DihydroxybenzaldehydeDiethanolamine4-amino-2-methylbutanoic acid*LysoPC 18:0LysoPC 18:2P-Menth-2-Ene-1,7-diol6-[(8R,9R,10R,14S,17S)-3-Hydroxy-4,4,8,10,14-Pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-Dodecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl]-2-Methylhept-6-Ene-2,3-diolserrat-14-en-3ÉÇ,21ÉÇ,29-triolVal-Ile-Asp*Hyp-ValIndanoneQuercetin-7-O-rutinoside*TetradecyldiethanolamineSulphuretinEpikatonic acidD-Allo-Isoleucine*3-(Pyrazol-1-yl)-L-alanine2'-Deoxyinosine 5'-phosphate1,3,7,11-Cembratetraen-13-olAglaiabbreviatin DArundinol BAglaiabbreviatin E12-Hydroxy-3,15-Friedelanedione*3-Oxo-1,12-Oleanadien-30-Oic AcidN-Acetylindole-3-carboxaldehyde*Xylarinorditerpene RTyramine*LysoPE 16:33,4-Dihydroxy-L-phenylalanine21ÉÇ-Hydroxy-27-nor-C(14a)-homogammacera-14(15)-ene-3,16-dione3-O-Acetyl-16-hydroxytrametenolic acid*3,8-Dihydroxy-1-methoxy-9,10-anthraquinone(1S,2S,4S,5'R,7S,8R,12S,13S,16S,18S)-16-hydroxy-5',7,13-trimethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-10-oneIsoguanosineL-Lysine*N,N'-Dimethylarginine;SDMA*6-Hydroxy-lupane-20(29)-en-3-one-28-oic acid*SpermidineTrehalosamineTriethylamine6-Demethoxycapillarisin4-(1,2,4a-trimethyl-5-methylidene-1,2,3,4,4a,5,8,8a-octahydronaphthalen-1-yl)butan-2-oneGanoderone AScolymoside*FeruloylspermidinePorilactone AN-Methyl-L-proline*Isovanillin*LysoPC 16:01-Linoleoylglycerol*methyl N-acetyl-N-hydroxycarbamateIle Val PheCMPPorilactone B5-Aminolevulinate2-Hexylphosphoric Acid*3,4-MethylenedioxycinnamaldehydeSenkyunolide M7,7A-DiepicoprinastatinThr-Thr3-O-Acetyl-16Ï«-hydroxydehydrotrametenolic acidEpigallocatechin-3-O-(3-O-methyl)gallateFagomineL-Cyclopentylglycine2-(4-hydroxyphenyl)-2H-chromene-3,5,7-triolLeu-Ala-Ile12-Hydroxy-Ï«-CadinolArg-Gly1,4,4a,5,8,8a-hexahydronaphthalene-4a,8a-diolGanoderic acid X*1-Methyl-2-[(Z)-6-undecyl]-4(1H)-quinoloneArgenteanol C*3-MethoxyanthranilateLysoPC 18:0(2n isomer)1,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-3-carboxylic acid5'-Methylthioadenosine1(10),4(15)-Germacradiene-2,5,6-Triol1,20(30)-Taraxastadien-3-one4-NitrophenolOctadecanamideDammara-20,23-Diene-3,25-diolAcetophenoneLysoPE 20:2(2n isomer)Hexyl dihydrogen phosphate*Lupeol Derivative 323S-Hydroxy-11,15-Dioxo-Ganoderic Acid DMO-Decanoyl-L-carnitineEnt-16Ï«,17-Dihydroxykauran-2-onePyridoxine7,2',6'-Trihydroxy-5-methoxyflavanone6-(6-aminohexanoylamino)hexanoate4(16),7,10-Dolabellatrien-3-olCordycepin*StachydrineSer-Leu-Leu10-Hydroxy-2,4A,6A,6B,9,9,12A-Heptamethyl-8-Oxo-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B-Octadecahydropicene-2-Carboxylic AcidGlycyl-leucine1-(4-Hydroxy-3-methoxyphenyl)-7-phenylheptane-3,5-diolN-Ethylglycine*Methyl 3-aminopropanoate2-(Dodecylamino)-3-phenyl-1-propanol6,8-Diprenyleriodictyol3,4-Secodammara-4(28),20,24-trien-3,26-dioic acidHypoglauterpenic Acid3'-Methoxy-[6]-Gingerdiol 3,5-diacetate(2-aminoethoxy)({3-hydroxy-2-[(9E)-octadec-9-enoyloxy]propoxy})phosphinic acidHydroxy-o-tolyl-acetic acidMG(24:1(15Z)/0:0/0:0)Trimethylamine N-Oxide*3,16-Dihydroxy-7,9(11)-Fernadien-12-oneTricin-7-O-neohesperidosidePectolinarigenin 7-rhamnosideEuphatexol D3-Oxooleana-11,13(18)-dien-28-oic acid6-ChloropurineLiangshanin AL-Glycyl-L-proline29-Hydroxypolyporenic acid CFouquieroneÉÇ-AtlantoneIsoshinanolone3,19,23-Trihydroxyurs-12-en-28-oic acid (Barbinervic acid)Gallocatechin gallate*N-(3-Indolylacetyl)-L-alanineLysoPC 14:0Virgatic acidfuro[2,3-h]quinolineEpinootkatol2-Amino-1-phenylethanol*L-Methionine S-oxideCytidineSer-Val-LeuDes-O-Methyllasiodiplodin*Isoquinoline4-Hydroxy-2,4A,6A,6B,9,9,12A-Heptamethyl-10,13-Dioxo-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Icosahydropicene-2-Carboxylic AcidMalonylapiinPro-Asp-Glu13,16-Docosadienamide2-Palmitoylglycerol*Pyran[3,4-b]indole-2-ketoneKadcoccinic acid DIle-Val-IleN-Monocinnamoylputrescine1,1,4a-trimethyl-7-propan-2-yl-4,4b,5,6,10,10a-hexahydro-3H-phenanthren-2-oneThr-Ile-IleLeu-Leu-AspDeoxyadenosine*Withafastuosin BSphinganine1-aminobenzocyclobuteneLysoPC 18:3(2n isomer)cis-4-Hydroxy-D-proline*2,3,19-Trihydroxy-24-oxo-olean-12-en-28-oic acidAsp-Pro-Phe2-{4-amino-1H-imidazo[4,5-d]pyridazin-1-yl}-5-(hydroxymethyl)oxolane-3,4-diolCadaverine3-(hydroxymethyl)-3,7a-dimethyl-4-methylidene-1,2,3a,3b,5,6,6a,7-octahydrocyclopenta[a]pentalen-5-olBetuloneHydroxyanthraquinoneCitreoanthrasteroide BLysoPC 15:0*3,4,5-Trimethoxybenzoic acid methyl ester3,3'-Oxydipropyl dibenzoatePunicic acidSaikogenin QFarnesyl acetoneLysoPE 16:1(E,6R)-6-[(1S,3S,6R,11S,12S,15R,16R)-6-hydroxy-7,7,12,16-tetramethyl-15-pentacyclo[9.7.0.01,3.03,8.012,16]octadec-8-enyl]-2-methylhept-2-enoic acidLysoPE 16:0N2-Acetyl-L-lysineL-2-AminoadipateIsonicotinic acid{[5-(6-amino-7H-purin-7-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid*10-Methoxyheptadec-1-En-4,6-Diyne-3,9-Diol3'-Deoxy-4-O-methylsappanolIle-AsnPro-Asn-Ala(5R)-5-(methylaminomethyl)oxolan-2-one*4-EthoxyphenolLL-2,6-Diaminoheptanedioate3,6,23-Trihydroxy-12-Ursen-28-Oic Acid2-[4,10-dihydroxy-3-[1-hydroxy-10-methyl-6-methylideneundeca-2,4,9-trien-2-yl]-6-(3-hydroxypropyl)-10-methylspiro[4.5]decan-7-ylidene]propanal*Germacrone5-HydroxytryptophanMyricetin-3-O-ÉÇ-D-glucoside*Isoliquiritigenin*2,3,19-Trihydroxyurs-12-en-28-oic acid (Hydroxypomolic Acid)Methionine2-propyl-1,3,2-dioxazolidineLysoPC 18:2(2n isomer)(4r)-5-amino-4-hydroxy-2-oxopentanoic acid*5,7,4'-TrihydroxyflavoneTuliposide D7(14),9-Chamigradien-2-one*(5e,10r)-10-methyl-7,8,9,10-tetrahydro-3h-oxecine-2,4-dione(+)-Gallocatechin2,2-dimethylchromene-6-carboxylic acid*3-epi-akebonic acidVignafuranDendronobilin IEutypeterpene BLuteolin*3-Epialphitolic acid*Quercetin-3-O-glucoside-7-O-rhamnoside*3-Methoxytyrosine*Nonaethylene glycolMethylthioadenosine sulfoxideL-Histidinol8-{4-Hydroxy-3,3-Dimethylbicyclo[4.1.0]Heptan-2-Yl}-6-Methyloct-5-En-2-oneGly-Pro-SerPhosphatidylcholine lyso 16:18-Methyltheophylline*Isoscopoletin-ÉÇ-D-glucosideCuscohygrine2,5-diaminohexanoic acid*Imidazole-4-acetate3-(Acetyloxy)-16-hydroxy-24-methylenelanosta-7,9(11)-dien-21-oic acid4-(3-Hydroxy-2-methylpropyl)phenolLauryldiethanolamineInonotsutriol C2-Aminooctadecane-1,16,18,18-tetraolN-Benzyloxycarbonyl-L-asparaginebeta-RotunolKoshikalideTaraxerolCnicothamnal24,25-Dinor-1,3,5(10)-Lupatriene1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine15-Acetyloxy-7-hydroxy-3-oxolanosta-8,24-dien-26-oic acid (Ganoderic Acid V)2-Oxo-2H-indole-3-acetic acidGly-Ile-GlnGarciosaterpene E*11alpha-Hydroxyandrosta-1,4-diene-3,17-dione3-Hydroxy-29(or30)-al-olean-12-en-28-oic acid*(+)-CatechinGuaianediolLevalide AL-HomocitrullineHeterodendrin4,9,10,14,17,20,20-heptamethyl-24-oxahexacyclo[14.6.2.01,14.04,13.05,10.017,22]tetracosane-8,23-dioneArginine methyl ester*8-HydroxyquinolineN-AcetylserotoninL-Leucyl-L-phenylalanineMyristamine oxidePhytosphingosine3ÉÇ,21ÉÇ,24,29-tetrahydroxy-16-oxoserrat-14-en3-O-Acetyl-9,11-Dehydro-ÉÇ-Boswellic Acid*21,24-Epoxy-23,25-Dihydroxycycloartan-3-one*Ilexgenin A11-hydroxy-3-(hydroxymethyl)-4,6a,10,10,13a,15b-hexamethyl-9-oxo-2,3,4,4a,5,6,6a,7,9,9a,10,11,12,13,13a,13b,14,15,15a,15b-icosahydro-1H-cyclohepta[1,2-a:5,4-a']dinaphthalene-4-carboxylic acidCornusalterin DBicyclo[4.2.0]octa-1,3,5-trien-7-amine, (R)-Hydroxyproline*Glycidyl Linoleate*Isocyperol*FisetinLauramideGlaucescic AcidHomoarginine1-[4-(3,3-Dimethyloxiran-2-Yl)-4-Hydroxybutan-2-Yl]-3A,3B,6,6,9A-Pentamethyl-7-Oxo-2H,3H,3Ah,3Bh,4H,5H,5Ah,6H,7H,8H,9H,9Ah,9Bh,10H,11H-Cyclopenta[A]Phenanthren-10-Yl Acetate*m-Aminophenylacetylene2-Linoleoylglycerol*5-hydroxymaltol9-Oxo-12Z-Octadecenoic acidN-(hexahydro-1H-benzo[de]anthracene-5-formyl)nornicotineLauramine oxideHispanoloneOctadecadienamide1,5-Bis(4-hydroxyphenyl)-2-(methoxymethyl)-4-penten-1-olLys-AlaSpermineQuercetin 3,4'-dimethyl ether*9-(acetoxymethylene)-2a,5a,8,8-tetramethyltetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-3-yl)-2-methylhept-2-enoic acidPhosphatidylcholine lyso 18:3HypoxanthinePieristoxin RPhyllnirurin*L-ArginineCitrullonolCarveolCyclo(Ala-Gly)6-Deoxy-6-sulfo-D-glucono-1,5-lactone18Ï«-Hydroxyglycyrrhetic Acid*Norephedrin 3-O-(2''-Phenylpropanyl)GlucosideN-methylphenylalanineGanoderic Acid 24CytarabineMoracin YN6,N6,N6-Trimethyl-L-lysinePhe-arg3,8-Dihydroxy-9-methoxypterocarpan8-hydroxy-5,9-dimethyl-14-methylidene-15-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acidS-Methyl GSHDysolenticin B8,9-Dihydroxy-P-Menth-1(6)-En-2-one1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-Dihydroxyphenyl)heptane-3,5-diolAflatrem12,13-DehydrogeranylgeraniolPhe-Tyr3,16-Dihydroxy-8-Fernene-7,11-dioneEremofukinone(S)-5'-Deoxy-5'-(methylsulfinyl)adenosineSpirost-5-en-3,17,24-triol (24-Hydroxypennogenin)AdenineMethyl-[8]-gingerol2,3,23-Trihydroxy-11,13(18)-Oleanadien-28-Oic Acid*2-AminoicoSane-1,5,7,19-tetraolHydroxystyrene*4-Ethynylbenzaldehyde5-[(2R,4S)-4-[(2R)-3,3-Dimethyloxiran-2-Yl]-4-Hydroxybutan-2-Yl]-9-Hydroxy-1,2,11,15,15-Pentamethyl-6-Oxapentacyclo[8.8.0.02,7.05,7.011,16]Octadecan-14-one3-acetylursolic acid9alpha-hydroxyandrosta-1,4-diene-3,17-dioneN6-ThreonylcarbamoyladenosineInosineL-SerineIsoleuconin CAristomollin D4,4'-dihydroxy-2,6-dimethoxydihydrochalcone(23S)-11Beta,23-Dihydroxy-8Alpha,9Beta,14Beta-Dammar-13(17)-Ene-3,24-dione7-Hydroxy-3,11,15-trioxolanosta-8,24-diene-26-oic acid (Ganoderic Acid GS-1)*LumichromeN-Hydroxypipecolic acid2-Hydroxy-22-(2-Hydroxypropan-2-Yl)-3,8,8,17,19-Pentamethyl-23,24-Dioxaheptacyclo[19.2.1.01,18.03,17.04,14.07,12.012,14]Tetracos-10-Ene-9,16-dione*Pentanoate6-methoxy-7-(3,7,11-trimethyldodeca-2,6,10-trienoxy)chromen-2-one3,23-Epoxy-olean-12-en-28-oic acid (Cyclocaric acid A)4-Methylazetidine-2-Carboxylic acid3Ï«,21Ï«-dihydroxy-16-oxoserrat-14-en-24-ylp-coumarate2-Aminooctadecane-1,4-diol16-oxolycoclavanol2-aminotetracoSane-1,6,7,23-tetraol*Lys-GlyIle-PheCladosporacid EPseudotropineLys-GluAMP*8-Hydroxycoumarin2-Ï«-Linolenoyl-glycerol-1-O-glucosideCaffeine4-(1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl)butan-2-oneAlliinDihydrokaempferide4-Ethyl-L-glutamic acid3Ï«,21Ï«-dihydroxyserrat-14-en-24-oic acid3-oxolanost-7-en-26-oic acid*1,3-Dihydroxypropan-2-yl 12-methyl-6-(6-methylheptyl)tridec-12-enoateQuercetin-3-O-alloside; Isohyperoside*Calycosin*2-aminotetradecane-1,3,4-triol9-Hydroxy-3,10(14),11-Germacratrien-15-alLignans Machilin F*Ala-Gln-LeuNicotinamide(2R,3R,4S)-2-(6-aminopurin-9-yl)-4-(hydroxymethyl)oxolan-3-ol*L-Valyl-L-PhenylalanineLysoPE 18:3*Met-Gly-PheRutin TrihydrateCoumarin-3-carboxylic Acid12-Ursen-25,3-olideValerine2-Amino-1,3-eicosanediol3-Oxolanosta-9(11),24-dien-26-oic acid (Coccinic Acid)LysoPC 16:0(2n isomer)3,16-Diacetyloxy-24-methylenelanost-8-en-21-oic acid (O-Acetylpachymic acid)alismanol ALys-Thr5-(2-Hydroxyethyl)-4-methylthiazolealismanol EDimethyl phthalateS-Methyl-L-cysteinePhomolactone BTuranosealismanol C4',7-dihydroxy-5-methoxy-8-methylflavanonealismanol BN7-Methylguanosinesn-Glycero-3-phosphocholinealismanol Qtetrahydrochromone MBaicalin*L-Lysine-Butanoic AcidN-Acetyl-L-hydroxyproline3-({4,8-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl}oxy)-2,4,5,6-tetrahydroxyhexanalN-hexanoylsphinganineLysoPE 20:4(2n isomer)*4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-1,2,3,5,6,7,8,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-9-ylium-3-ol6-Aminonicotinamide(+)-Aristolone(9R,13R)-10,11-dihydro-12-oxo-15-phytoenoic acid(-)-EpigallocatechinHexadecyl ethanolamine3-Oxo-12-Oleanen-27-Oic Acid*LysoPE 18:1*1-Amino-1-cyclobutane-carboxylic-acid*7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-oneDehydrochamaecynenolGuanosine*3-Hydroxy-23-oxoolean-12-en-28-oic acid (Gypsogenin)LysoPE 15:0(2n isomer)*3-Hydroxylup-20(29)-en-24-oic acid2,5-O-Di-CinnamylSorbitolMethyl serinateDextropimaric acid(Oxiran-2-yl)methyl octadeca-9,12-dienoate*Sofalcone1-MethoxyphaseollinCostunolide16-Hydroxy-3-oxolanosta-7,24-diene-21-oic acid Gamma-lactone (Kulactone)11-Hydroperoxy-1,9-Bisaboladien-3-ol3beta,23-dihydroxy-12-ene-28-ursolic acidChiloscyphone*3,16-Dihydroxylanosta-7,9(11),24-trien-21-oic acidN2-(2-Hydroxysuccinoyl)arginine(7S)-bicyclo[4.2.0]octa-1,3,5-trien-7-amineisoshyobunone2-Hydroxy-2-(Hydroxymethyl)-6,6-Dimethylbicyclo[3.1.1]Heptan-3-onecyclo-(Gly-Phe)N-(12-methyltetradecyl)propionamideAlanylproline2,5,8-trimethyldeca-2,4,7-triene-1,10-diolIsoscutellarein*1-AminocyclopentanecarboxylateMethyl jasmonate16,23:16:24-Diepoxycycloart-7-Ene-3,12,15,25-Tetrol(4E)-13-(cyclopent-2-en-1-yl)-7-[1-(4-hydroxyphenyl)cyclohexyl]tridec-4-enoic acidHistamineKojibiose1,11-Dihydroxy-18-Oleanen-3-one*15-Acetyl-3,15-Dihydroxy-24-Methylenelanosta-7,9(11)-Dien-21-Oic Acid9-Alpha-Ribofuranosyladenine*L-Tyrosine*5'-DeoxyadenosineLiquidambronovic acidHerniarin3,5,7,4'-Tetrahydroxy-CoumaronochromoneAsp-Lys*Guanosine-5'-diphosphate(10S)-xylariterpenoid AHexadecanamideL-4-Hydroxyglutamate semialdehyde*LeucocyanidinGanoderic Acid BEffusanin A4-Hydroxy-3-methoxyphenethyl AcetateO-Acetyl-L-homoserineGanoderic Acid J3-MethylcytidineVanillin acetateLysoPE 20:5L-Leucine*LysoPE 20:23-Hydroxyurs-5(6),12,18(19)-trien-28-oic acid (Uncargenin B)6,7-dimethyl-4-(2,3,4,5-tetrahydroxypentyl)-1H-quinoxaline-2,3-dioneNicotinate7-Methoxy-coumarin-8-yl-acetaldehyde5-Hydroxy-7,8,4'-TrimethoxyflavanoneSynephrineN(pi)-Methyl-L-histidine6-Hydroxy-3-oxooleana-11,13(18)-dien-28-oic acid2-aminotetracoSane-1,5,21,23-tetraol*Phe-AlaKaempferol-3-O-rutinoside*falseMetabolic Remodeling of Soil Ecosystems by the medicinal fungus Wolfiporia cocos: Bidirectional Feedback and Functional ConsequencesWidely targeted metabolomics based on UPLC-MS/MS was performed to explore metabolic differences between two tissues of Wolfiporia cocos sclerotium. Samples include inner white tissue (Fuling Bai) and outer layer (Fuling Pi) of sclerotium, with 3 biological replicates for each group. A total of 1565 metabolites were identified to reveal tissue-specific metabolic characteristics of medicinal fungus W. cocos.2027-08-102026-08-10MTBLS15360