The online KEGG, HMDB database was used to annotate the metabolites by matching the exact molecular mass data (m/z) of samples with those from database. If a mass difference between observed and the database value was less than 10 ppm, the metabolite would be annotated and the molecular formula of metabolites would further be identified and validated by the isotopic distribution measurements. We also used a in-house fragment spectrum library of metabolites to validate the metabolite identidification.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["An ACQUITY UPLC HSS T3 column (100 mm×2.1 mm, 1.8 µm, Waters) was used for separation. The mobile phase consists of phase A (5 mmol/L ammonium acetate + 5 mmol/L acetic acid + water) and phase B (acetonitrile). Gradient elution conditions were set as follows: 0~0.8 min , 2% ~ 70%B; 0.8~2.8 min , 70% ~ 90% B; 2.8~5.3 min, 90% ~ 99% B; 5.3~5.9 min, 99% B; 5.9~7.5 min , 99% ~ 2%B;7.5~7.6 min , 2% B;7.6~10.0 min, 2% B; The flow rate is 0.35 mL/min. The injection volume for each sample was 4 µL. The column oven was maintained at 40℃.
"],"publication":["Multi-omics Analysis of ACAD11-mediated Lipid Metabolic Reprogramming in the Prognosis of Clear Cell Renal Cell."],"submitter_name":["Heng Zhao"],"submitter_affiliation":["The First Affiliated Hospital, Zhejiang University School of Medicine"],"organism_part":["kidney"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Weigh 50 mg (±5 mg) of the sample and add 500 μL of 80 % icy methanol solution. Put a small amount of steel balls and grind them with a grinder, and incubated for 30 min at-20℃ to precipitate proteins, and centrifuged at 20000 g for 10 min at 4℃, supernatant centrifuged for 5 min again. The supernatant was transferred to a fresh vial for UPLC-HRMS analysis. The quality control (QC) sample was prepared by mixing an equal aliquot of the supernatant of samples.
"],"organism":["Homo sapiens"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS15414"],"author":["Heng Zhao. The First Affiliated Hospital, Zhejiang University School of Medicine. zhaoh001121@163.com.","Mengqin Wang.","Xiaoli Sun.","Ling Du.","Shengyi Feng.","Xing Huang.","Lisong Teng.","Chao He.","Zhanyi Shou.","Lei Wang. The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. wloncologist@126.com.","Yuting Li."],"data_transformation_protocol":["The acquired MS data pretreatments including peak picking, peak grouping, retention time correction, second peak grouping, and annotation of isotopes and adducts was performed using XCMS software. LC−MS raw data files were converted into mzXML format and then processed by the XCMS, CAMERA and metaX toolbox implemented with the R software. Each ion was identified by combining retention time (RT) and m/z data. Intensities of each peaks were recorded and a three dimensional matrix containing arbitrarily assigned peak indices (retention time-m/z pairs), sample names (observations) and ion intensity information (variables) was generated.
"],"study_factor":["Sample type"],"submitter_email":["zhaoh001121@163.com"],"sample_collection_protocol":["Eleven paired ccRCC and adjacent normal tissues were obtained from patients undergoing surgical resection at the First Affiliated Hospital of Zhejiang University School of Medicine between November 2024 and May 2025. Patients were included if they had pathologically confirmed ccRCC without prior systemic therapy or concurrent malignancies.
"],"omics_type":["Metabolomics"],"study_design":["Metabolomics","QC","untargeted analysis","Q-Exactive","Thermo Scientific Vanquish Flex UHPLC System","XCMS","Homo sapiens","Tumor","Q Exactive Plus","Normal","Kidney","Renal cell carcinoma of kidney except renal pelvis"],"curator_keywords":["Metabolomics","QC","untargeted analysis","Q-Exactive","Thermo Scientific Vanquish Flex UHPLC System","XCMS","Homo sapiens","Tumor","Q Exactive Plus","Normal","Kidney","Renal cell carcinoma of kidney except renal pelvis"],"mass_spectrometry_protocol":["A high-resolution tandem mass spectrometer Q-Exactive Plus (Thermo Fisher Scientific) was used to detect metabolites eluted form the column. Each sample was operated in both positive and negative electrospray ionization mode. ESI temperature is 350℃. The voltage is +3800 volts in positive ion mode and-3400 volts in negative ion mode. The sweep gas pressure of the ion source is 0 Arb, Gas 1 (Auxiliary gas) pressures set to 15 Arb, Gas 2 (Sheath gas) pressures set to 50 Arb. The mass spectrometric data were obtained with full scan and data-dependent acquisition (DDA) modes. In one acquisition cycle, the full scan acquisition range is 70-1050 Da, and the resolution is 70k, AGC target is set to 3E6, maximum injection time is set to 100 ms. Then, the top 5 signal ions with a signal accumulation intensity of more than 100000 were selected from the full scan for DDA scanning, the DDA resolution is 17.5k, Maximum IT is set to 50 ms. Dynamic exclusion is set to 6 s.
"],"metabolite_name":["PS(18:0/18:0)","PC(16:1(9Z)/18:1(9Z))","Salmeterol","Phenylacetylglutamine","Durandro","gamma-Aminobutyric acid","Guaiacol","Drometrizole","(2R,3S,4R,5R,8R,10R,11R,13S,14R)-11-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one","Methyl nicotinate","Ergonovine","Tropane","Flufenacet","PC(18:1(9Z)/16:0)","Polidocanol","1,3,5-Trinitrobenzene","(2S,3R,4R)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid","2,6-Dimethoxyphenol","Flavin mononucleotide","Phenylalanylproline","2-[4-[4-(4-Carbamimidoylphenyl)piperazin-1-yl]piperidin-1-yl]acetic acid","Cervonyl carnitine","Hexanoylcarnitine","Zidebactam","Eniluracil","N5-Acetylornithine","Desipramine","Dihexyl phthalate","2-Ethyl-2-oxazoline","Iohexol","2,3-Butanedione monoxime","N6-Acetyl-L-lysine","Molindone","Brequinar","3-Hydroxy-11Z-octadecenoylcarnitine","Pracinostat","L-Theanine","Leucylleucine","PC(P-16:0/18:2(9Z,12Z))","Fexofenadine","LysoPC(14:0/0:0)","gamma-Glutamylphenylalanine","4-Methylstyrene","Proline betaine","Nitro (2S)-2-amino-5-(diaminomethylideneamino)pentanoate","Lidocaine","N-Methyl-L-proline","Thiazolidine-4-carboxylic acid","Pantothenic acid","Phenylalanine betaine","6-Benzylaminopurine","Diphenyl sulfone","Triethylenemelamine","Buclizine","Azelastine","Procyclidine","13-Docosenamide","Carmustine","Olpadronic acid","Aminoadipic acid","4-Methoxybenzaldehyde","Metoprolol acid","LysoPC(16:1/0:0)","(1S,2S,6R,15S,16R)-5-(Cyclopropylmethyl)-16-(2-hydroxy-3,3-dimethylbutan-2-yl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol","4-Hydroxyquinoline","Basimglurant","3-Methyl-3-buten-2-one","Ornithine","Platydesminium","Isovalerylcarnitine","Indole","PC(18:2(9Z,12Z)/18:2(9Z,12Z))","N-Arachidonoylglycine","DL-Arginine","2-Octenoylcarnitine","Dibutylamine","Phenylalanylglycine","L-Carnitine","Palmitoleamide","2,4,6-Triethyl-1,3,5-trioxane","Adenosine triphosphate","Adenosine","PC(16:0/18:1(9Z))","Adenosine monophosphate","Gabexate","Allopurinol","Chelidonine","Dilinoleoylphosphatidylcholine","Guanidoacetic acid","Pro-Ile","Oxyphenonium","2,3-Dihydro-4-methylfuran","Sitamaquine","Butabarbital","Proxyl nitroxide","PC(16:0/18:2(9Z,12Z))","Homo-L-arginine","PC(15:0/15:0)","PC(18:0/18:1(9Z))","2,2'-Bioxirane","LysoPC(20:2(11Z,14Z)/0:0)","Donepezil metabolite M4","Sebacoyl-L-carnitine","Docosa-4,7,10,13,16-pentaenoyl carnitine","Riboprine","Alanyltryptophan","PC(20:4(5Z,8Z,11Z,14Z)/P-16:0)","1-Piperidinepropanol, alpha-cyclohexyl-4-(3-hydroxyphenyl)-3,4-dimethyl-","O-Acetylserine","Mefenacet","2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide","Sphingosine","3-Dehydrosphinganine","gamma-Glutamylleucine","Botryodiplodin","O-Anisidine","Methyl L-argininate","Tyrosine methylester","Tiglic aldehyde","Lysine","Cyclobenzaprine","1,4-Dichloro-2-nitrobenzene","Butethal","Hexadecanedioic acid mono-L-carnitine ester","Trehalose","PC(18:1(11Z)/P-18:1(9Z))","1,2-Dipalmitoylphosphatidylcholine","Guanine","Quinmerac","1-Methylnicotinamide","Chloramphenicol succinate","24-Epibrassinolide","Epinastine","Tetrahydrozoline","1,3-Diaminopropane","(2E,5Z,7E)-Decatrienoylcarnitine","(1R)-4-[18-[(4R)-4-Hydroxy-2,6,6-trimethylcyclohexen-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethylcyclohex-3-en-1-ol","3,4-Diaminopyridine","Glycylleucine","Bamifylline","7-Methoxy-6-methyl-2H-1-benzopyran-2-one","7-Methylguanine","Monopropionylcadaverine","2,4-Dimethyloxazole","xi-2,3-Dihydro-3-methylfuran","Nicotine imine","Nicotredole","Ethylene glycol diglycidyl ether","Zolmitriptan","Succinonitrile","Pipecolic acid","N-Acetylimidazole","N-[(5-Hydroxy-2-pyridinyl)methyl]adenosine","Mirtazapine","Indole-3-carboxaldehyde","Zymonic acid","Stachyose","Sakuranetin","PC(38:5)","Carbamazepine-O-quinone","2-Amino-3,4-dimethylimidazo[4,5-f]quinoline","Nitrilotriacetic acid","Carbetapentane","(2S)-6-Oxa-1-azabicyclo[3.1.0]hexane-2-carboxylic acid","Olvanil","N-Methylsuccinimide","LysoPC(17:0/0:0)","Anandamide","N-Methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-pyrrolidone","Phenyl-Alanine","PC(38:6)","Apatinib","Erythrogran","Trimethylamine N-oxide","4-(3-Tert-Butylamino-2-hydroxypropoxy)benzimidazol-2-one","Porphyrinogen","Roxithromycin","Azimexon","Tiagabine","Ramipril Diketopiperazine","(3R)-Palonosetron","1-Phenylpiperazine","PC(38:3)","Colforsin daropate","Aceneuramic acid","3-Ketosphingosine","2-Ethyl-5-methyloxazole","Vinyl carbamate","Nivacortol","1-Methyladenosine","3-Methylhistamine","Sarcosine","Heptanoylcarnitine","PC(16:0/20:5(5Z,8Z,11Z,14Z,17Z))","PC(38:4)","1-Methylhistamine","N-Acetylgalactosamine","Isoleucylproline","O-Phosphoethanolamine","2-Hydroxybenzaldehyde","5-Dodecenoylcarnitine","(¡À)-Tryptophan","L-Threonine","alpha-Hydroxymetoprolol","Proscillaridin","Naftopidil","Trigonelline","SM(d18:1/18:1(9Z))","Prunitrin","Edetic Acid","2-Methyl-N-(5-methyl-3-isoxazolyl)-1,1,4-trioxo-3H-1$l^{6},2-benzothiazine-3-carboxamide","N-Acetyl-D-glucosamine","Trifolirhizin","Prometon","Monoethylglycinexylidide","Trimesic acid","(Z)-p-Methoxycinnamic acid","7-Methylguanosine","Ubiquinone-1","1,2,3,4,Tetrahydro-1,5,7-trimethylnapthalene","Imiquimod","Pyrrole-2-carboxylic acid","Histidinyl-Leucine","p-Anisidine","Methyl methylthio selenide","LysoPC(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)","Quinaldic acid","Ibandronate","Sulforaphane","L-Tryptophan","Methyl L-leucinate","1,3-Dimethoxymethyl-5,5-diphenylbarbituric acid","Methacrylamide","PC(P-16:0/22:5(4Z,7Z,10Z,13Z,16Z))","2-Lysophosphatidylcholine","Rimiterol","3-(Dimethylaminomethyl)indole","3-Hydroxylidocaine","4-Amino-o-cresol","Testosterone","Morpholine","Vernolate","Pentaethylene glycol","(¡À)-erythro-Isoleucine","Leukotriene B5","Niranthin","L-Valine","Vidarabine","Emedastine","Cuminaldehyde","Sunepitron","Azithromycin","Ropivacaine","Creatine","Chlorzoxazone","Diaveridine","Tetradecenoylcarnitine","2-amino-5-(amino-dimethylamino-methylidene)amino-pentanoic acid","Octopine","O-(2-Aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenoate","Koeniginequinone A","Laurocapram","Retapamulin","N6-Methyl-2'-deoxyadenosine","trans-2-Dodecenoylcarnitine","Bexarotene","L-Cystine","PC(16:0/P-18:1(9Z))","N6-Methyladenosine","Heptabarbital","N2,N2-Dimethylguanosine","1-Benzylpiperazine","Alpinetin Methyl Ether","12-Hydroxy-12-octadecanoylcarnitine","N-Hydroxy-2-acetamidofluorene","Erythromycin","Guanidinosuccinic acid","PS(18:1(9Z)/18:0)","4-Aminoantipyrine","LysoPC(18:1/0:0)","Acetohydroxamic Acid","2-(4-Nitrobenzylidene)malononitrile","PC(18:0/20:4(5Z,8Z,11Z,14Z))","Nicotine","5-Aminoimidazole","3,4',5-Biphenyltriol","PC(18:2(9Z,12Z)/P-18:1(9Z))","1,1-Dimethylbiguanide","2-Methoxybenzaldehyde","Olmesartan","Tiaprofenic acid","Indinavir","Isoleucine","Phensuximide","Hyoscyamine","Lys-Ala-Arg","PC(14:0/P-18:0)","2-Hydroxyphenethylamine","A-Ketoglutaric acid oxime","Methyl 1-pentyl-1H-indole-3-carboxylic acid","trans-Hexadec-2-enoyl carnitine","1,2-Dihexanoyl-sn-glycero-3-phosphoethanolamine","alpha-Tocotrienol","PC(14:0/P-18:1(9Z))","Dodecylbenzene","2-Propionylpyrrole","Tulathromycin A","Glutamine","Vinyl ether","5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-","1,2-Dimethylimidazole","1-Methylinosine","Methyl l-phenylalaninate","Butadiene monoxide","(S)-Norfenfluramine","Lacosamide","Piperidine, 4-(1a,10b-dihydro-6H-dibenzo(3,4:6,7)cyclohept(1,2-b)oxiren-6-ylidene)-","[3-[2-Aminoethoxy(hydroxy)phosphoryl]oxy-2-hydroxypropyl] hexadecanoate","D-Maltose","Guanazole","PC(O-36:5)","Histidine","cis-5-Tetradecenoylcarnitine","3-Amino-2-oxazolidone","Saccharopine","Norendoxifen","Pentadecanoylcarnitine","1,10-Phenanthroline","Crenolanib","D-Kynurenine","PC(20:3(5Z,8Z,11Z)/P-18:1(11Z))","3, 5-Tetradecadiencarnitine","2-Pentenal","2,5-Dihydro-2,4-dimethyloxazole","N4-Acetylcytidine","Articaine","Glycerophosphocholine","Methylhistidine","Dienogest","Ergothioneine","Phenylphosphonic acid","Dicarbine","1-Aminocyclopropanecarboxylic acid","Sulpiride","Prostacyclin (not favourable)","Indoleacetic acid","Benzanthrone","N-Lactoylphenylalanine","Salicylic acid","2-Methylguanosine","Manidipine","Decanoylcarnitine","Dimethylnitramine","Ketamine","Choline","(2S)-5-(Diaminomethylideneamino)-4-methyl-2-(methylamino)pentanoic acid","Leucylphenylalanine","D-Tyrosine","2-Hexenoylcarnitine","Rhusflavanone","Ramosetron","Homatropine","Endralazine","Octenoyl-L-carnitine","Desloratadine","4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide","Indoline","Norelgestromin","Palmitoyl Ara-C","Diethylenetriamine","Aniline","Asymmetric dimethylarginine","PC(16:0/P-18:1(11Z))","(2S)-2-Amino-3-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]oxypropanoic acid","Phthalide","Menadione","Daurisoline","(2S)-5-[Carbamimidoyl(methyl)amino]-2-(methylamino)pentanoic acid","2-Furoic acid","Palmitoylcarnitine","Phosphorylcholine","N-desalkyludenafil","S-Adenosylhomocysteine","PC(P-16:0/20:3(5Z,8Z,11Z))","3-hydroxydodecanoyl carnitine","Irbesartan","D-Lysine","LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","Visnagin","(1S,10S,21R)-7-Ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone","2-[(4-Phenoxyphenyl)sulfonylmethyl]thiirane","Isonicotinamide","PC(20:3(5Z,8Z,11Z)/P-18:1(9Z))","Heptadecanoyl carnitine","LysoPC(22:5(4Z,7Z,10Z,13Z,16Z)/0:0)","9-Octadecenamide","Acridine","Bz-Pro-Phe-Arg-pNA","Leucine","Soybean lecithin","3-Hydroxybutyrylcarnitine","(E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid","1-Methyladenosin","LysoPC(P-18:0/0:0)","PC(18:1(9Z)/14:0)","N,N-Dimethyl-4-nitrosoaniline","Piperidine","Vapiprost","Monoelaidin","Conhydrinone","1,4-Naphthoquinone","Cimetidine","Aldosine","5-Ethyl-2-methyloxazole","3-Hydroxy-cis-5-tetradecenoylcarnitine","7-Amino-4-methylcoumarin","Licoagroside B","[(2R,3R,4R,5S)-3,4-Diacetyloxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate","alpha-Methyltryptamine","Methohexital","Simeton","3,4-Dichloronitrobenzene","Palustrine","Riboflavin","6,7-Dihydro-2,3-dimethyl-5H-cyclopentapyrazine","Ramipril","N(4)-Oleylcytosine arabinoside","Isoguvacine","Peramine","Octadecenoylcarnitine","isomaltulose","Batyl alcohol","Quinoline","N-Phenyl-1-naphthylamine","pyrrolidin-1-amine","LysoPC(P-18:1(9Z)/0:0)","1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine","Stearidonyl carnitine","Biotin","Anileridine","N-desmethylmirtazapine","2-Methoxy-4-vinylphenol","2-Methylbutyroylcarnitine","Amlodipine","N1-Acetylspermidine","3-Hydroxyanthranilic acid","3-ureido-isobutyrate","Methylphenidate","7-[(1R,2R,3R)-3-Hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]-5-heptenoic acid","5-Hydroxyindoleacetic acid","Cladosporin","(E)-Raphanusanin","Nevanimibe","Butyrylcarnitine","(2-Hydroxy-3-phosphonooxypropyl) octadec-9-enoate","Thiobencarb","LysoPC(P-16:0/0:0)","PC(32:1)","1-Amino-2-methylanthraquinone","Cloranolol","DL-Acetylcarnitine","2,3-Epoxyphylloquinone","N-Methylaniline","1-Penten-3-one","Fluoxetine","Anastrozole","Isoproturon","Glycitein","Ginkgolide A","LysoPC(18:0/0:0)","PC(18:0/14:0)","1-(9Z-Eicosenoyl)-sn-glycero-3-phosphocholine","9-Decenoylcarnitine","3-Hydroxyisovalerylcarnitine","1,4-Pentanediamine, N4-(5-(hexyloxy)-6-methoxy-4-methyl-8-quinolinyl)-","Pyrazine","PC(18:3(6Z,9Z,12Z)/P-18:1(11Z))","Tiglylcarnitine","Ciprofloxacin","PC(16:0/P-16:0)","Octocrylene","3-Hydroxyhexadecanoylcarnitine","Zomepirac","4-Amino-1-[(2R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one","1-Palmitoylphosphatidylcholine","Pipequaline","DL-Proline","1-(7Z-Hexadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine","Octanoylcarnitine","4'-N-desmethylolanzapine","Buspirone","Tetradecanoylcarnitine","Lucerastat","4'-Methoxyacetophenone","Palmitoleoylethanolamde","Biliverdin","PC(16:1(9Z)/17:0)","2,6 Dimethylheptanoyl carnitine","2-Phosphoglyceric acid","Hexadecenoylcarnitine","Memantine","Levomedetomidine","Oxazolidine","1-Methylguanine","O-Demethyltramadol","Garbanzol","PC(32:0)","3-hydroxydecanoyl carnitine","3,5-Dimethylpyrazole","2-Hydroxymyristoylcarnitine","2'-C-Methylcytidine","Tetrahydrofurfuryl acetate","Fentanyl","Proline","Deferiprone","DL-Cysteine","Avizafone","Marimastat","Pizotifen","Thiamine","Glycoursodeoxycholic acid","4,4'-Bipyridine","N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate","N-Acetyltryptophan","Tomatidine","Dodecanoylcarnitine","Pimelylcarnitine","L-Tyrosine","Isobutyryl-L-carnitine","Midazolam","3-Pyridinemethanol, 6-amino-alpha-(((1-methyl-4-phenylbutyl)amino)methyl)-","Levofloxacin","LysoPC(18:4(6Z,9Z,12Z,15Z)/0:0)","Thioproline","Felbamate","6,7-Dihydro-2,6-dimethyl-5H-cyclopentapyrazine","Phenylalanylphenylalanine","Alverine","2'-Deoxyguanosine 5'-monophosphate","PC(30:0)","Trachelanthine","PC(40:5)","myo-Inositol 6-phosphate","(R)-3-hydroxybutyrylcarnitine","Piclamilast","PC(20:4(8Z,11Z,14Z,17Z)/P-16:0)","Linden ether","10-Hydroxycamptothecin","Dropropizine","LysoPC(18:1(11Z)/0:0)","PC(40:6)","Butyl methacrylate","3-[[(2S)-2,4-Dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid","(S)-2-Azetidinecarboxylic acid","Norfloxacin","Pyrovalerone","1,3-Di-o-tolylguanidine","LysoPC(20:3/0:0)","Propionylcarnitine","N-Didesmethyl-tamoxifen","Prizidilol","2-Ethenyl-1-oxidopyridin-1-ium","Aspartylphenylalanine","(1S-Endo)-5-(4-Chloro-3-methylphenyl)-1-((4-methylphenyl)methyl)-N-(1,3,3-trimethylbicyclo(2.2.1)hept-2-yl)-1H-pyrazole-3-carboxamide","OR-1855","Ivacaftor","Valsartan","Tetraethylene glycol","Dinitolmide","5'-Methylthioadenosine","Pafenolol","Piperine","PC(18:0/18:2(9Z,12Z))","Vicriviroc","PC(16:1(9Z)/P-18:1(9Z))","PC(18:3(6Z,9Z,12Z)/P-18:1(9Z))","gamma-Aminobutyric acid cetyl ester","Creatinine","3,17,20-Trihydroxypregnane","1-O-Hexadecyl-sn-glycero-3-phosphocholine","Diacetyl","PC(14:1(9Z)/P-18:0)","N,N-Dimethylacrylamide","3-Hydroxyhexanoylcarnitine","Arachidyl carnitine","N-Acetoxy-phip","Pyridazine","LysoPC(20:1(11Z)/0:0)","Carisoprodol","Mogrol","Gallamonum","N-a-Acetyl-L-arginine","Hexaethylene glycol","4'-Methoxychalcone","Dictamnine","Remifentanil Acid","Sacubitrilat","Acepromazine","4-Nitrophenyl sulfate","Bilirubin","1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamide","Cinobufagin","Betaine","Tetraglyme","L-Alanine","Luminol","4-Aminohippuric acid","Cyclopentanone","Hesperetin","Quinazolin-4-ylamine","Triphenylmethane","Symmetric dimethylarginine","Vecuronium","Alfuzosin","1-Methylhistidine","Alpha-hydroxymidazolam","Trofosfamide","2,2'-Methylenebis(4-methyl-6-tert-butylphenol)","Sphinganine","Trioxsalen","D-Glutamic acid","3',4'-Di-O-methylquercetin","Citiolone","Motolimod","1-Pyrrolidinecarboxaldehyde","Thymolphthalein","Metoprolol","Phenoxazine","Oleoylethanolamide","PC(18:1(9Z)/18:2(6Z,9Z))","PS(18:0/18:1(9Z))","Clupanodonyl carnitine","Nudifloramide","PC(P-16:0/22:4(7Z,10Z,13Z,16Z))","2-Methylimidazole","7,8-Dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione","Beta-Aminopropionitrile","(R)-Higenamine","Dictyoquinazol A","Tesmilifene","Ephedrine","Quinoline-3-carboxamide","PC(16:1(9Z)/16:1(9Z))","(R)-Apiumetin","2-Methylpyrrolidine","Tetrahydropapaverine","Metallibure","Tandutinib","beta-noroxycodol","1-Phenylbiguanide","Suprofen","(2Z)-2-Morpholin-4-yliminoacetonitrile","2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine","Kynurenic acid","4-Ethyl-2-methyloxazole","1-Methylpyrrolidine","Palmitoylethanolamide","Methionine","Castanospermine","LysoPC(22:4(7Z,10Z,13Z,16Z)/0:0)","Biguanide","Carbinoxamine","Linezolid","3-Hydroxyhexadecadienoylcarnitine","4-Hydroxyproline","L-Histidinol","Nb-Methyltetrahydroharmol","Phosphocreatinine","Clemastine","Prilocaine","2-Amino-p-cresol","D-Glutamine","N-Desmethylaminopyrine","1',2'-Dihydro-1,1'-dimethyl-2'-oxo-4,4'-bipyridinium(1+)","N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide","PC(36:5)","Niacinamide","N'-[(6-Oxo-5-prop-2-enyl-1-cyclohexa-2,4-dienylidene)methyl]-2-[4-(phenylmethyl)-1-piperazinyl]acetohydrazide","Bakuchiol","(+)-2,3-Dihydro-3-methyl-1H-pyrrole","6-Keto-decanoylcarnitine","1-(2-(1-Adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea","Lumacaftor","tert-Butyl isocyanide","Ferulic acid","Tenax GC","Pyrroline","Crotamiton","Leucylproline","Ilepcimide","Racemethionine","D-Valine","15(R)-hydroperoxy-EPE","3-(Carboxymethylamino)propanoic acid","PC(18:1(11Z)/P-18:1(11Z))","1-Methoxy-1H-indole-3-carboxaldehyde","8-Epiloganic acid","2-Hydroxyacetophenone","LysoPC(18:3(6Z,9Z,12Z)/0:0)","N-Acetylserotonin","Virginiamycin M1","Propoxate","Atraton","PC(36:3)","Phytosphingosine","Spergualin","LysoPC(18:2/0:0)","Tetrahydro-2-methyl-3-furanol","Indoleacrylic acid","Busulfan","1-Naphthyl isocyanate","N-Linoleoyl Glycine","Propranolol","5-amino valeric acid betaine","2,4-Pentadienal","Lenticin","4-Methylimidazole","9-Hexadecenoylcarnitine","1-[3-(Trifluoromethyl)phenyl]piperazine","Buformin","Crotonic acid betaine","PC(36:4)","L-Arginine","N-Acetyl-DL-phenylalanine","Rocuronium","(-)-alpha-Tocopherol","Septacidin","N8-Acetylspermidine","1'-Hydroxymidazolam beta-D-glucuronide","(-)-Morphine","Tizanidine","N-Phenylacetyl pyroglutamic acid","PC(36:1)","N6,N6,N6-Trimethyl-L-lysine","PC(14:0/18:0)","Pronetalol","Tropine","Methyl (methylthio)methyl disulfide","5-Butyloxazole","FAD","Shanzhiside","(+)-Hyoscyamine","Choline sulfate","LysoPC(16:0/0:0)","Cortisone","Dimaprit","PC(36:2)","D-Proline","Paracetamol cysteine","Apabetalone","LysoPC(20:4/0:0)","LysoPE(20:0/0:0)","D-Phenylalanine","2-Pyrrolidinone","(9Z)-3-Hydroxydodecenoylcarnitine","1-[(5-Methoxy-3-indolylidene)methylamino]-2-pentylguanidine","D-Histidine","Phosphoguanidinoacetate","Tyrphostin AG 126","Temanogrel","Saterinone","PC(18:1(9Z)/18:1(11Z))","Pirimicarb","Cellobiose","3-Hydroxy-5,8-tetradecadienoylcarnitine","4-Cyano-N-(3-(cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta(b)pyran-3-yl)methyl)phenyl)benzenesulfonamide","Oleoyl glycine","Alizapride","Caffeine","1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine","Myristoylcarnitine","4-(2-Amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol","Debrisoquine","Maltotriose","Sarpogrelate","Carbamazepine","D-Threonine","(¡À)-4-Methylene-2-pyrrolidinecarboxylic acid","N-Acetylhistamine","8-Methylquinoline","Theophylline","2-Acetyl-3-ethylidene-3,4,5,6-tetrahydropyridine","Testosterone decanoate","3-Hydroxy-9-hexadecenoylcarnitine","4-Pentenal","alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol","Nicotyrine","PC(34:3)","Piperazine","Pyridoxamine","Glucosamine 6-phosphate","Perazine","Epoxyoxophorone","5-Amino-2-methoxyphenol","Acridine carboxamide","Biochanin A","L-Acetylcarnitine","S-Adenosylmethionine","PC(34:4)","Nylidrin","Allixin","4-(2,6,6-Trimethyl-1,3-cyclohexadien-1-yl)-2-butanone","Octylguanidine","Etoperidone","(S)-Laudanosine","N-Lauroylsarcosine","6-Ketoestriol","1,4-Butanediol diglycidyl ether","Nonoxynol-9","3-Methylglutarylcarnitine","PC(34:1)","3-Phosphoglyceric acid","Cotinine","2-Piperidinone","(2R,3R)-2-Aminooctadecane-1,3-diol","Aloxistatin","Ethanol, 2-(pentyl(5-(1-piperidinyl)(1,2,4)triazolo(1,5-a)pyrimidin-7-yl)amino)-","Histamine","1-Pyrroline-5-carboxylic acid","LysoPC(20:0/0:0)","PC(34:2)","Eplerenone","Aminophenazone","5'-Deoxyadenosine","N,N'-Dibenzhydrylethane-1,2-diamine","Genkwanin","1-Pyrimidinylpiperazine","Herniarin","3-hydroxyoctanoyl carnitine","Erianin","Gamma-linolenyl carnitine","Tripdiolide","Pyrrolidine","4,5-Dimethyloxazole","2-(2-Nitroimidazol-1-yl)-n-(3,3,3-trifluoropropyl)acetamide","Acebutolol","Tasquinimod","9-beta-d-Arabinofuranosylguanine","7alpha,8alpha-Dihydroxycalonectrin","1,4-Pentadien-3-one","2-Methylfuran","2-trans,4-cis-Decadienoylcarnitine","Norvaline","Gliclazide","delta-Valerolactone","Daidzein","3-(1-Pyrrolidinyl)-2-butanone"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omics Analysis of ACAD11-mediated Lipid Metabolic Reprogramming in the Prognosis of Clear Cell Renal Cell","description":"Clear cell renal cell carcinoma (ccRCC) is pathologically characterized by profound intracellular lipid droplet accumulation. To explore the dysregulated lipid metabolic network and identify crucial drivers, an integrated transcriptomic and untargeted metabolomic analysis was conducted. In this study, metabolism-related differentially expressed genes (mDEGs) were screened from the TCGA-KIRC dataset and validated in an independent cohort of 11 paired clinical ccRCC specimens using single-sample gene set enrichment analysis (ssGSEA), confirming the widespread suppression of lipid metabolic pathways. Weighted gene co-expression network analysis (WGCNA) integrated with transcriptomic profiling identified ACAD11 as a core metabolic hub gene. Downregulation of ACAD11 at both transcript and protein levels was validated across clinical stages, WHO/ISUP grades, and tissue microarrays via immunohistochemistry (IHC). Liquid chromatography-mass spectrometry (LC-MS)-based untargeted metabolomics was performed on clinical ccRCC tissues and matched adjacent non-tumor controls to capture the ACAD11-associated metabolic landscape. Multi-omics integration demonstrated that ACAD11 deficiency blocks fatty acid $\\beta$-oxidation, leading to the pathological accumulation of multiple acylcarnitines. This dataset provides liquid chromatography-mass spectrometry (LC-MS) raw data for ccRCC metabolic profiling.","dates":{"publication":"2026-08-31","submission":"2026-08-21"},"accession":"MTBLS15414","cross_references":{"HMDB":["HMDB0341202","HMDB0258416","HMDB0242322","HMDB0242304","HMDB0247185","HMDB0247881","HMDB0260137","HMDB0258119","HMDB0258158","HMDB0260140","HMDB0258086","HMDB0260132","HMDB0031963","HMDB0245605","HMDB0251558","HMDB0257831","HMDB0253747","HMDB0031180","HMDB0030276","HMDB0260205","HMDB0002166","HMDB0030197","HMDB0030377","HMDB0033747","HMDB0034666","HMDB0037115","HMDB0034491","HMDB0244035","HMDB0244033","HMDB0002327","HMDB0255793","HMDB0037113","HMDB0244070","HMDB0244089","HMDB0257271","HMDB0032037","HMDB0244167","HMDB0061918","HMDB0244170","HMDB0244204","HMDB0251779","HMDB0244228","HMDB0011103","HMDB0002026","HMDB0031771","HMDB0257189","HMDB0243848","HMDB0243849","HMDB0254934","HMDB0243898","HMDB0257856","HMDB0001563","HMDB0003099","HMDB0243964","HMDB0253220","HMDB0243979","HMDB0032960","HMDB0244000","HMDB0244003","HMDB0246131","HMDB0013622","HMDB0004684","HMDB0247613","HMDB0004693","HMDB0002231","HMDB0010199","HMDB0004031","HMDB0013623","HMDB0004705","HMDB0010201","HMDB0004702","HMDB0013633","HMDB0012535","HMDB0004685","HMDB0060042","HMDB0004667","HMDB0010203","HMDB0244510","HMDB0010204","HMDB0002265","HMDB0005045","HMDB0010208","HMDB0003876","HMDB0010210","HMDB0061709","HMDB0006294","HMDB0010213","HMDB0010359","HMDB0244873","HMDB0255423","HMDB0249030","HMDB0245347","HMDB0245380","HMDB0032148","HMDB0245405","HMDB0245484","HMDB0000360","HMDB0032230","HMDB0245456","HMDB0245492","HMDB0030540","HMDB0245505","HMDB0029673","HMDB0032150","HMDB0038832","HMDB0032425","HMDB0032916","HMDB0037142","HMDB0033127","HMDB0031861","HMDB0035281","HMDB0244980","HMDB0060711","HMDB0302754","HMDB0245008","HMDB0001906","HMDB0245025","HMDB0029884","HMDB0031335","HMDB0245060","HMDB0245084","HMDB0033958","HMDB0033373","HMDB0000439","HMDB0038336","HMDB0245154","HMDB0245155","HMDB0000402","HMDB0000005","HMDB0032390","HMDB0000422","HMDB0245229","HMDB0011723","HMDB0040203","HMDB0245718","HMDB0341419","HMDB0000341","HMDB0004225","HMDB0003391","HMDB0041346","HMDB0134105","HMDB0245564","HMDB0029661","HMDB0032151","HMDB0246049","HMDB0258446","HMDB0247745","HMDB0032429","HMDB0037296","HMDB0033131","HMDB0061112","HMDB0032335","HMDB0060741","HMDB0061120","HMDB0248998","HMDB0000011","HMDB0002203","HMDB0000387","HMDB0006116","HMDB0000754","HMDB0240652","HMDB0002096","HMDB0245912","HMDB0032352","HMDB0000491","HMDB0001566","HMDB0033172","HMDB0245299","HMDB0252906","HMDB0094710","HMDB0061643","HMDB0341257","HMDB0060382","HMDB0061126","HMDB0246621","HMDB0246620","HMDB0013825","HMDB0260013","HMDB0246294","HMDB0003681","HMDB0246991","HMDB0032887","HMDB0246373","HMDB0040933","HMDB0034577","HMDB0255806","HMDB0062551","HMDB0039650","HMDB0038462","HMDB0032330","HMDB0011718","HMDB0029757","HMDB0014018","HMDB0246465","HMDB0037288","HMDB0240459","HMDB0246550","HMDB0000017","HMDB0062775","HMDB0059982","HMDB0140929","HMDB0001253","HMDB0244545","HMDB0033098","HMDB0249714","HMDB0030991","HMDB0257536","HMDB0251018","HMDB0003355","HMDB0011134","HMDB0000472","HMDB0059805","HMDB0033002","HMDB0247852","HMDB0258664","HMDB0000521","HMDB0246942","HMDB0000473","HMDB0060550","HMDB0002886","HMDB0001316","HMDB0060791","HMDB0001412","HMDB0247297","HMDB0247234","HMDB0000477","HMDB0002232","HMDB0247424","HMDB0060052","HMDB0004710","HMDB0004704","HMDB0004701","HMDB0247617","HMDB0004708","HMDB0242602","HMDB0247599","HMDB0001973","HMDB0059716","HMDB0247706","HMDB0246854","HMDB0247749","HMDB0033585","HMDB0247933","HMDB0038165","HMDB0248003","HMDB0000034","HMDB0000448","HMDB0002226","HMDB0030819","HMDB0015495","HMDB0028691","HMDB0248129","HMDB0000481","HMDB0015104","HMDB0000186","HMDB0013624","HMDB0014631","HMDB0248327","HMDB0245804","HMDB0015496","HMDB0248396","HMDB0002759","HMDB0002124","HMDB0015498","HMDB0002212","HMDB0001043","HMDB0248699","HMDB0060671","HMDB0248736","HMDB0000784","HMDB0014327","HMDB0000944","HMDB0004461","HMDB0248986","HMDB0249016","HMDB0001870","HMDB0249037","HMDB0030637","HMDB0013679","HMDB0034250","HMDB0003134","HMDB0014948","HMDB0249243","HMDB0249248","HMDB0041188","HMDB0014442","HMDB0249450","HMDB0040202","HMDB0014934","HMDB0003033","HMDB0000511","HMDB0000033","HMDB0015267","HMDB0002884","HMDB0000637","HMDB0250123","HMDB0014994","HMDB0000653","HMDB0000619","HMDB0030299","HMDB0015147","HMDB0030282","HMDB0002177","HMDB0000094","HMDB0035365","HMDB0040938","HMDB0030975","HMDB0250478","HMDB0038122","HMDB0030290","HMDB0251212","HMDB0031340","HMDB0001310","HMDB0006483","HMDB0246552","HMDB0031518","HMDB0013609","HMDB0001187","HMDB0000609","HMDB0060475","HMDB0251526","HMDB0000181","HMDB0240698","HMDB0250913","HMDB0001264","HMDB0001032","HMDB0246857","HMDB0000071","HMDB0000012","HMDB0015320","HMDB0015364","HMDB0251173","HMDB0031151","HMDB0251213","HMDB0251226","HMDB0251283","HMDB0002925","HMDB0031253","HMDB0030791","HMDB0001473","HMDB0251360","HMDB0251373","HMDB0251377","HMDB0029580","HMDB0251386","HMDB0004983","HMDB0002001","HMDB0251413",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