MetaboLights

application/xml

ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/m_MTBLS15414_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/m_MTBLS15414_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/a_MTBLS15414_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/a_MTBLS15414_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/s_MTBLS15414.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RK1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RB2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RH1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RF2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RB1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RK2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RG1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RC2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_QC4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RM1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_QC1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RB2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RC1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RG2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RM2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RL2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RH2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RH1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RC2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_QC3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RB1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RM1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RM2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RI1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RH2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_QC4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RA2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_QC2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RC1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RG2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RF1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_QC1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_QC3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RI2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RL2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RA1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RG1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RF2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_QC2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RA2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RI1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RL1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RF1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RA1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RI2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RE2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RE1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RK1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RK2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/pos_RE1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RL1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414/FILES/RAW_FILES/neg_RE2.rawprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15414The online KEGG, HMDB database was used to annotate the metabolites by matching the exact molecular mass data (m/z) of samples with those from database. If a mass difference between observed and the database value was less than 10 ppm, the metabolite would be annotated and the molecular formula of metabolites would further be identified and validated by the isotopic distribution measurements. We also used a in-house fragment spectrum library of metabolites to validate the metabolite identidification.MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseAn ACQUITY UPLC HSS T3 column (100 mm×2.1 mm, 1.8 µm, Waters) was used for separation. The mobile phase consists of phase A (5 mmol/L ammonium acetate + 5 mmol/L acetic acid + water) and phase B (acetonitrile). Gradient elution conditions were set as follows: 0~0.8 min , 2% ~ 70%B; 0.8~2.8 min , 70% ~ 90% B; 2.8~5.3 min, 90% ~ 99% B; 5.3~5.9 min, 99% B; 5.9~7.5 min , 99% ~ 2%B;7.5~7.6 min , 2% B;7.6~10.0 min, 2% B; The flow rate is 0.35 mL/min. The injection volume for each sample was 4 µL. The column oven was maintained at 40℃.Multi-omics Analysis of ACAD11-mediated Lipid Metabolic Reprogramming in the Prognosis of Clear Cell Renal Cell.Heng ZhaoThe First Affiliated Hospital, Zhejiang University School of Medicinekidneymass spectrometry assayWeigh 50 mg (±5 mg) of the sample and add 500 μL of 80 % icy methanol solution. Put a small amount of steel balls and grind them with a grinder, and incubated for 30 min at-20℃ to precipitate proteins, and centrifuged at 20000 g for 10 min at 4℃, supernatant centrifuged for 5 min again. The supernatant was transferred to a fresh vial for UPLC-HRMS analysis. The quality control (QC) sample was prepared by mixing an equal aliquot of the supernatant of samples.Homo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS15414Heng Zhao. The First Affiliated Hospital, Zhejiang University School of Medicine. zhaoh001121@163.com.Mengqin Wang.Xiaoli Sun.Ling Du.Shengyi Feng.Xing Huang.Lisong Teng.Chao He.Zhanyi Shou.Lei Wang. The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. wloncologist@126.com.Yuting Li.The acquired MS data pretreatments including peak picking, peak grouping, retention time correction, second peak grouping, and annotation of isotopes and adducts was performed using XCMS software. LC−MS raw data files were converted into mzXML format and then processed by the XCMS, CAMERA and metaX toolbox implemented with the R software. Each ion was identified by combining retention time (RT) and m/z data. Intensities of each peaks were recorded and a three dimensional matrix containing arbitrarily assigned peak indices (retention time-m/z pairs), sample names (observations) and ion intensity information (variables) was generated.Sample typezhaoh001121@163.comEleven paired ccRCC and adjacent normal tissues were obtained from patients undergoing surgical resection at the First Affiliated Hospital of Zhejiang University School of Medicine between November 2024 and May 2025. Patients were included if they had pathologically confirmed ccRCC without prior systemic therapy or concurrent malignancies. MetabolomicsMetabolomicsQCuntargeted analysisQ-ExactiveThermo Scientific Vanquish Flex UHPLC SystemXCMSHomo sapiensTumorQ Exactive PlusNormalKidneyRenal cell carcinoma of kidney except renal pelvisMetabolomicsQCuntargeted analysisQ-ExactiveThermo Scientific Vanquish Flex UHPLC SystemXCMSHomo sapiensTumorQ Exactive PlusNormalKidneyRenal cell carcinoma of kidney except renal pelvisA high-resolution tandem mass spectrometer Q-Exactive Plus (Thermo Fisher Scientific) was used to detect metabolites eluted form the column. Each sample was operated in both positive and negative electrospray ionization mode. ESI temperature is 350℃. The voltage is +3800 volts in positive ion mode and-3400 volts in negative ion mode. The sweep gas pressure of the ion source is 0 Arb, Gas 1 (Auxiliary gas) pressures set to 15 Arb, Gas 2 (Sheath gas) pressures set to 50 Arb. The mass spectrometric data were obtained with full scan and data-dependent acquisition (DDA) modes. In one acquisition cycle, the full scan acquisition range is 70-1050 Da, and the resolution is 70k, AGC target is set to 3E6, maximum injection time is set to 100 ms. Then, the top 5 signal ions with a signal accumulation intensity of more than 100000 were selected from the full scan for DDA scanning, the DDA resolution is 17.5k, Maximum IT is set to 50 ms. Dynamic exclusion is set to 6 s.PS(18:0/18:0)PC(16:1(9Z)/18:1(9Z))SalmeterolPhenylacetylglutamineDurandrogamma-Aminobutyric acidGuaiacolDrometrizole(2R,3S,4R,5R,8R,10R,11R,13S,14R)-11-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-oneMethyl nicotinateErgonovineTropaneFlufenacetPC(18:1(9Z)/16:0)Polidocanol1,3,5-Trinitrobenzene(2S,3R,4R)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid2,6-DimethoxyphenolFlavin mononucleotidePhenylalanylproline2-[4-[4-(4-Carbamimidoylphenyl)piperazin-1-yl]piperidin-1-yl]acetic acidCervonyl carnitineHexanoylcarnitineZidebactamEniluracilN5-AcetylornithineDesipramineDihexyl phthalate2-Ethyl-2-oxazolineIohexol2,3-Butanedione monoximeN6-Acetyl-L-lysineMolindoneBrequinar3-Hydroxy-11Z-octadecenoylcarnitinePracinostatL-TheanineLeucylleucinePC(P-16:0/18:2(9Z,12Z))FexofenadineLysoPC(14:0/0:0)gamma-Glutamylphenylalanine4-MethylstyreneProline betaineNitro (2S)-2-amino-5-(diaminomethylideneamino)pentanoateLidocaineN-Methyl-L-prolineThiazolidine-4-carboxylic acidPantothenic acidPhenylalanine betaine6-BenzylaminopurineDiphenyl sulfoneTriethylenemelamineBuclizineAzelastineProcyclidine13-DocosenamideCarmustineOlpadronic acidAminoadipic acid4-MethoxybenzaldehydeMetoprolol acidLysoPC(16:1/0:0)(1S,2S,6R,15S,16R)-5-(Cyclopropylmethyl)-16-(2-hydroxy-3,3-dimethylbutan-2-yl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol4-HydroxyquinolineBasimglurant3-Methyl-3-buten-2-oneOrnithinePlatydesminiumIsovalerylcarnitineIndolePC(18:2(9Z,12Z)/18:2(9Z,12Z))N-ArachidonoylglycineDL-Arginine2-OctenoylcarnitineDibutylaminePhenylalanylglycineL-CarnitinePalmitoleamide2,4,6-Triethyl-1,3,5-trioxaneAdenosine triphosphateAdenosinePC(16:0/18:1(9Z))Adenosine monophosphateGabexateAllopurinolChelidonineDilinoleoylphosphatidylcholineGuanidoacetic acidPro-IleOxyphenonium2,3-Dihydro-4-methylfuranSitamaquineButabarbitalProxyl nitroxidePC(16:0/18:2(9Z,12Z))Homo-L-argininePC(15:0/15:0)PC(18:0/18:1(9Z))2,2'-BioxiraneLysoPC(20:2(11Z,14Z)/0:0)Donepezil metabolite M4Sebacoyl-L-carnitineDocosa-4,7,10,13,16-pentaenoyl carnitineRiboprineAlanyltryptophanPC(20:4(5Z,8Z,11Z,14Z)/P-16:0)1-Piperidinepropanol, alpha-cyclohexyl-4-(3-hydroxyphenyl)-3,4-dimethyl-O-AcetylserineMefenacet2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamideSphingosine3-Dehydrosphinganinegamma-GlutamylleucineBotryodiplodinO-AnisidineMethyl L-argininateTyrosine methylesterTiglic aldehydeLysineCyclobenzaprine1,4-Dichloro-2-nitrobenzeneButethalHexadecanedioic acid mono-L-carnitine esterTrehalosePC(18:1(11Z)/P-18:1(9Z))1,2-DipalmitoylphosphatidylcholineGuanineQuinmerac1-MethylnicotinamideChloramphenicol succinate24-EpibrassinolideEpinastineTetrahydrozoline1,3-Diaminopropane(2E,5Z,7E)-Decatrienoylcarnitine(1R)-4-[18-[(4R)-4-Hydroxy-2,6,6-trimethylcyclohexen-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethylcyclohex-3-en-1-ol3,4-DiaminopyridineGlycylleucineBamifylline7-Methoxy-6-methyl-2H-1-benzopyran-2-one7-MethylguanineMonopropionylcadaverine2,4-Dimethyloxazolexi-2,3-Dihydro-3-methylfuranNicotine imineNicotredoleEthylene glycol diglycidyl etherZolmitriptanSuccinonitrilePipecolic acidN-AcetylimidazoleN-[(5-Hydroxy-2-pyridinyl)methyl]adenosineMirtazapineIndole-3-carboxaldehydeZymonic acidStachyoseSakuranetinPC(38:5)Carbamazepine-O-quinone2-Amino-3,4-dimethylimidazo[4,5-f]quinolineNitrilotriacetic acidCarbetapentane(2S)-6-Oxa-1-azabicyclo[3.1.0]hexane-2-carboxylic acidOlvanilN-MethylsuccinimideLysoPC(17:0/0:0)AnandamideN-Methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-pyrrolidonePhenyl-AlaninePC(38:6)ApatinibErythrogranTrimethylamine N-oxide4-(3-Tert-Butylamino-2-hydroxypropoxy)benzimidazol-2-onePorphyrinogenRoxithromycinAzimexonTiagabineRamipril Diketopiperazine(3R)-Palonosetron1-PhenylpiperazinePC(38:3)Colforsin daropateAceneuramic acid3-Ketosphingosine2-Ethyl-5-methyloxazoleVinyl carbamateNivacortol1-Methyladenosine3-MethylhistamineSarcosineHeptanoylcarnitinePC(16:0/20:5(5Z,8Z,11Z,14Z,17Z))PC(38:4)1-MethylhistamineN-AcetylgalactosamineIsoleucylprolineO-Phosphoethanolamine2-Hydroxybenzaldehyde5-Dodecenoylcarnitine(¡À)-TryptophanL-Threoninealpha-HydroxymetoprololProscillaridinNaftopidilTrigonellineSM(d18:1/18:1(9Z))PrunitrinEdetic Acid2-Methyl-N-(5-methyl-3-isoxazolyl)-1,1,4-trioxo-3H-1$l^{6},2-benzothiazine-3-carboxamideN-Acetyl-D-glucosamineTrifolirhizinPrometonMonoethylglycinexylidideTrimesic acid(Z)-p-Methoxycinnamic acid7-MethylguanosineUbiquinone-11,2,3,4,Tetrahydro-1,5,7-trimethylnapthaleneImiquimodPyrrole-2-carboxylic acidHistidinyl-Leucinep-AnisidineMethyl methylthio selenideLysoPC(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)Quinaldic acidIbandronateSulforaphaneL-TryptophanMethyl L-leucinate1,3-Dimethoxymethyl-5,5-diphenylbarbituric acidMethacrylamidePC(P-16:0/22:5(4Z,7Z,10Z,13Z,16Z))2-LysophosphatidylcholineRimiterol3-(Dimethylaminomethyl)indole3-Hydroxylidocaine4-Amino-o-cresolTestosteroneMorpholineVernolatePentaethylene glycol(¡À)-erythro-IsoleucineLeukotriene B5NiranthinL-ValineVidarabineEmedastineCuminaldehydeSunepitronAzithromycinRopivacaineCreatineChlorzoxazoneDiaveridineTetradecenoylcarnitine2-amino-5-(amino-dimethylamino-methylidene)amino-pentanoic acidOctopineO-(2-Aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenoateKoeniginequinone ALaurocapramRetapamulinN6-Methyl-2'-deoxyadenosinetrans-2-DodecenoylcarnitineBexaroteneL-CystinePC(16:0/P-18:1(9Z))N6-MethyladenosineHeptabarbitalN2,N2-Dimethylguanosine1-BenzylpiperazineAlpinetin Methyl Ether12-Hydroxy-12-octadecanoylcarnitineN-Hydroxy-2-acetamidofluoreneErythromycinGuanidinosuccinic acidPS(18:1(9Z)/18:0)4-AminoantipyrineLysoPC(18:1/0:0)Acetohydroxamic Acid2-(4-Nitrobenzylidene)malononitrilePC(18:0/20:4(5Z,8Z,11Z,14Z))Nicotine5-Aminoimidazole3,4',5-BiphenyltriolPC(18:2(9Z,12Z)/P-18:1(9Z))1,1-Dimethylbiguanide2-MethoxybenzaldehydeOlmesartanTiaprofenic acidIndinavirIsoleucinePhensuximideHyoscyamineLys-Ala-ArgPC(14:0/P-18:0)2-HydroxyphenethylamineA-Ketoglutaric acid oximeMethyl 1-pentyl-1H-indole-3-carboxylic acidtrans-Hexadec-2-enoyl carnitine1,2-Dihexanoyl-sn-glycero-3-phosphoethanolaminealpha-TocotrienolPC(14:0/P-18:1(9Z))Dodecylbenzene2-PropionylpyrroleTulathromycin AGlutamineVinyl ether5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-1,2-Dimethylimidazole1-MethylinosineMethyl l-phenylalaninateButadiene monoxide(S)-NorfenfluramineLacosamidePiperidine, 4-(1a,10b-dihydro-6H-dibenzo(3,4:6,7)cyclohept(1,2-b)oxiren-6-ylidene)-[3-[2-Aminoethoxy(hydroxy)phosphoryl]oxy-2-hydroxypropyl] hexadecanoateD-MaltoseGuanazolePC(O-36:5)Histidinecis-5-Tetradecenoylcarnitine3-Amino-2-oxazolidoneSaccharopineNorendoxifenPentadecanoylcarnitine1,10-PhenanthrolineCrenolanibD-KynureninePC(20:3(5Z,8Z,11Z)/P-18:1(11Z))3, 5-Tetradecadiencarnitine2-Pentenal2,5-Dihydro-2,4-dimethyloxazoleN4-AcetylcytidineArticaineGlycerophosphocholineMethylhistidineDienogestErgothioneinePhenylphosphonic acidDicarbine1-Aminocyclopropanecarboxylic acidSulpirideProstacyclin (not favourable)Indoleacetic acidBenzanthroneN-LactoylphenylalanineSalicylic acid2-MethylguanosineManidipineDecanoylcarnitineDimethylnitramineKetamineCholine(2S)-5-(Diaminomethylideneamino)-4-methyl-2-(methylamino)pentanoic acidLeucylphenylalanineD-Tyrosine2-HexenoylcarnitineRhusflavanoneRamosetronHomatropineEndralazineOctenoyl-L-carnitineDesloratadine4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamideIndolineNorelgestrominPalmitoyl Ara-CDiethylenetriamineAnilineAsymmetric dimethylargininePC(16:0/P-18:1(11Z))(2S)-2-Amino-3-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]oxypropanoic acidPhthalideMenadioneDaurisoline(2S)-5-[Carbamimidoyl(methyl)amino]-2-(methylamino)pentanoic acid2-Furoic acidPalmitoylcarnitinePhosphorylcholineN-desalkyludenafilS-AdenosylhomocysteinePC(P-16:0/20:3(5Z,8Z,11Z))3-hydroxydodecanoyl carnitineIrbesartanD-LysineLysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)Visnagin(1S,10S,21R)-7-Ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone2-[(4-Phenoxyphenyl)sulfonylmethyl]thiiraneIsonicotinamidePC(20:3(5Z,8Z,11Z)/P-18:1(9Z))Heptadecanoyl carnitineLysoPC(22:5(4Z,7Z,10Z,13Z,16Z)/0:0)9-OctadecenamideAcridineBz-Pro-Phe-Arg-pNALeucineSoybean lecithin3-Hydroxybutyrylcarnitine(E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid1-MethyladenosinLysoPC(P-18:0/0:0)PC(18:1(9Z)/14:0)N,N-Dimethyl-4-nitrosoanilinePiperidineVapiprostMonoelaidinConhydrinone1,4-NaphthoquinoneCimetidineAldosine5-Ethyl-2-methyloxazole3-Hydroxy-cis-5-tetradecenoylcarnitine7-Amino-4-methylcoumarinLicoagroside B[(2R,3R,4R,5S)-3,4-Diacetyloxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetatealpha-MethyltryptamineMethohexitalSimeton3,4-DichloronitrobenzenePalustrineRiboflavin6,7-Dihydro-2,3-dimethyl-5H-cyclopentapyrazineRamiprilN(4)-Oleylcytosine arabinosideIsoguvacinePeramineOctadecenoylcarnitineisomaltuloseBatyl alcoholQuinolineN-Phenyl-1-naphthylaminepyrrolidin-1-amineLysoPC(P-18:1(9Z)/0:0)1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholineStearidonyl carnitineBiotinAnileridineN-desmethylmirtazapine2-Methoxy-4-vinylphenol2-MethylbutyroylcarnitineAmlodipineN1-Acetylspermidine3-Hydroxyanthranilic acid3-ureido-isobutyrateMethylphenidate7-[(1R,2R,3R)-3-Hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]-5-heptenoic acid5-Hydroxyindoleacetic acidCladosporin(E)-RaphanusaninNevanimibeButyrylcarnitine(2-Hydroxy-3-phosphonooxypropyl) octadec-9-enoateThiobencarbLysoPC(P-16:0/0:0)PC(32:1)1-Amino-2-methylanthraquinoneCloranololDL-Acetylcarnitine2,3-EpoxyphylloquinoneN-Methylaniline1-Penten-3-oneFluoxetineAnastrozoleIsoproturonGlyciteinGinkgolide ALysoPC(18:0/0:0)PC(18:0/14:0)1-(9Z-Eicosenoyl)-sn-glycero-3-phosphocholine9-Decenoylcarnitine3-Hydroxyisovalerylcarnitine1,4-Pentanediamine, N4-(5-(hexyloxy)-6-methoxy-4-methyl-8-quinolinyl)-PyrazinePC(18:3(6Z,9Z,12Z)/P-18:1(11Z))TiglylcarnitineCiprofloxacinPC(16:0/P-16:0)Octocrylene3-HydroxyhexadecanoylcarnitineZomepirac4-Amino-1-[(2R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one1-PalmitoylphosphatidylcholinePipequalineDL-Proline1-(7Z-Hexadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineOctanoylcarnitine4'-N-desmethylolanzapineBuspironeTetradecanoylcarnitineLucerastat4'-MethoxyacetophenonePalmitoleoylethanolamdeBiliverdinPC(16:1(9Z)/17:0)2,6 Dimethylheptanoyl carnitine2-Phosphoglyceric acidHexadecenoylcarnitineMemantineLevomedetomidineOxazolidine1-MethylguanineO-DemethyltramadolGarbanzolPC(32:0)3-hydroxydecanoyl carnitine3,5-Dimethylpyrazole2-Hydroxymyristoylcarnitine2'-C-MethylcytidineTetrahydrofurfuryl acetateFentanylProlineDeferiproneDL-CysteineAvizafoneMarimastatPizotifenThiamineGlycoursodeoxycholic acid4,4'-BipyridineN-Tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonateN-AcetyltryptophanTomatidineDodecanoylcarnitinePimelylcarnitineL-TyrosineIsobutyryl-L-carnitineMidazolam3-Pyridinemethanol, 6-amino-alpha-(((1-methyl-4-phenylbutyl)amino)methyl)-LevofloxacinLysoPC(18:4(6Z,9Z,12Z,15Z)/0:0)ThioprolineFelbamate6,7-Dihydro-2,6-dimethyl-5H-cyclopentapyrazinePhenylalanylphenylalanineAlverine2'-Deoxyguanosine 5'-monophosphatePC(30:0)TrachelanthinePC(40:5)myo-Inositol 6-phosphate(R)-3-hydroxybutyrylcarnitinePiclamilastPC(20:4(8Z,11Z,14Z,17Z)/P-16:0)Linden ether10-HydroxycamptothecinDropropizineLysoPC(18:1(11Z)/0:0)PC(40:6)Butyl methacrylate3-[[(2S)-2,4-Dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid(S)-2-Azetidinecarboxylic acidNorfloxacinPyrovalerone1,3-Di-o-tolylguanidineLysoPC(20:3/0:0)PropionylcarnitineN-Didesmethyl-tamoxifenPrizidilol2-Ethenyl-1-oxidopyridin-1-iumAspartylphenylalanine(1S-Endo)-5-(4-Chloro-3-methylphenyl)-1-((4-methylphenyl)methyl)-N-(1,3,3-trimethylbicyclo(2.2.1)hept-2-yl)-1H-pyrazole-3-carboxamideOR-1855IvacaftorValsartanTetraethylene glycolDinitolmide5'-MethylthioadenosinePafenololPiperinePC(18:0/18:2(9Z,12Z))VicrivirocPC(16:1(9Z)/P-18:1(9Z))PC(18:3(6Z,9Z,12Z)/P-18:1(9Z))gamma-Aminobutyric acid cetyl esterCreatinine3,17,20-Trihydroxypregnane1-O-Hexadecyl-sn-glycero-3-phosphocholineDiacetylPC(14:1(9Z)/P-18:0)N,N-Dimethylacrylamide3-HydroxyhexanoylcarnitineArachidyl carnitineN-Acetoxy-phipPyridazineLysoPC(20:1(11Z)/0:0)CarisoprodolMogrolGallamonumN-a-Acetyl-L-arginineHexaethylene glycol4'-MethoxychalconeDictamnineRemifentanil AcidSacubitrilatAcepromazine4-Nitrophenyl sulfateBilirubin1-(beta-D-Ribofuranosyl)-1,4-dihydronicotinamideCinobufaginBetaineTetraglymeL-AlanineLuminol4-Aminohippuric acidCyclopentanoneHesperetinQuinazolin-4-ylamineTriphenylmethaneSymmetric dimethylarginineVecuroniumAlfuzosin1-MethylhistidineAlpha-hydroxymidazolamTrofosfamide2,2'-Methylenebis(4-methyl-6-tert-butylphenol)SphinganineTrioxsalenD-Glutamic acid3',4'-Di-O-methylquercetinCitioloneMotolimod1-PyrrolidinecarboxaldehydeThymolphthaleinMetoprololPhenoxazineOleoylethanolamidePC(18:1(9Z)/18:2(6Z,9Z))PS(18:0/18:1(9Z))Clupanodonyl carnitineNudifloramidePC(P-16:0/22:4(7Z,10Z,13Z,16Z))2-Methylimidazole7,8-Dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dioneBeta-Aminopropionitrile(R)-HigenamineDictyoquinazol ATesmilifeneEphedrineQuinoline-3-carboxamidePC(16:1(9Z)/16:1(9Z))(R)-Apiumetin2-MethylpyrrolidineTetrahydropapaverineMetallibureTandutinibbeta-noroxycodol1-PhenylbiguanideSuprofen(2Z)-2-Morpholin-4-yliminoacetonitrile2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamineKynurenic acid4-Ethyl-2-methyloxazole1-MethylpyrrolidinePalmitoylethanolamideMethionineCastanospermineLysoPC(22:4(7Z,10Z,13Z,16Z)/0:0)BiguanideCarbinoxamineLinezolid3-Hydroxyhexadecadienoylcarnitine4-HydroxyprolineL-HistidinolNb-MethyltetrahydroharmolPhosphocreatinineClemastinePrilocaine2-Amino-p-cresolD-GlutamineN-Desmethylaminopyrine1',2'-Dihydro-1,1'-dimethyl-2'-oxo-4,4'-bipyridinium(1+)N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl AmidePC(36:5)NiacinamideN'-[(6-Oxo-5-prop-2-enyl-1-cyclohexa-2,4-dienylidene)methyl]-2-[4-(phenylmethyl)-1-piperazinyl]acetohydrazideBakuchiol(+)-2,3-Dihydro-3-methyl-1H-pyrrole6-Keto-decanoylcarnitine1-(2-(1-Adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)ureaLumacaftortert-Butyl isocyanideFerulic acidTenax GCPyrrolineCrotamitonLeucylprolineIlepcimideRacemethionineD-Valine15(R)-hydroperoxy-EPE3-(Carboxymethylamino)propanoic acidPC(18:1(11Z)/P-18:1(11Z))1-Methoxy-1H-indole-3-carboxaldehyde8-Epiloganic acid2-HydroxyacetophenoneLysoPC(18:3(6Z,9Z,12Z)/0:0)N-AcetylserotoninVirginiamycin M1PropoxateAtratonPC(36:3)PhytosphingosineSpergualinLysoPC(18:2/0:0)Tetrahydro-2-methyl-3-furanolIndoleacrylic acidBusulfan1-Naphthyl isocyanateN-Linoleoyl GlycinePropranolol5-amino valeric acid betaine2,4-PentadienalLenticin4-Methylimidazole9-Hexadecenoylcarnitine1-[3-(Trifluoromethyl)phenyl]piperazineBuforminCrotonic acid betainePC(36:4)L-ArginineN-Acetyl-DL-phenylalanineRocuronium(-)-alpha-TocopherolSeptacidinN8-Acetylspermidine1'-Hydroxymidazolam beta-D-glucuronide(-)-MorphineTizanidineN-Phenylacetyl pyroglutamic acidPC(36:1)N6,N6,N6-Trimethyl-L-lysinePC(14:0/18:0)PronetalolTropineMethyl (methylthio)methyl disulfide5-ButyloxazoleFADShanzhiside(+)-HyoscyamineCholine sulfateLysoPC(16:0/0:0)CortisoneDimapritPC(36:2)D-ProlineParacetamol cysteineApabetaloneLysoPC(20:4/0:0)LysoPE(20:0/0:0)D-Phenylalanine2-Pyrrolidinone(9Z)-3-Hydroxydodecenoylcarnitine1-[(5-Methoxy-3-indolylidene)methylamino]-2-pentylguanidineD-HistidinePhosphoguanidinoacetateTyrphostin AG 126TemanogrelSaterinonePC(18:1(9Z)/18:1(11Z))PirimicarbCellobiose3-Hydroxy-5,8-tetradecadienoylcarnitine4-Cyano-N-(3-(cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta(b)pyran-3-yl)methyl)phenyl)benzenesulfonamideOleoyl glycineAlizaprideCaffeine1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholineMyristoylcarnitine4-(2-Amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenolDebrisoquineMaltotrioseSarpogrelateCarbamazepineD-Threonine(¡À)-4-Methylene-2-pyrrolidinecarboxylic acidN-Acetylhistamine8-MethylquinolineTheophylline2-Acetyl-3-ethylidene-3,4,5,6-tetrahydropyridineTestosterone decanoate3-Hydroxy-9-hexadecenoylcarnitine4-Pentenalalpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanolNicotyrinePC(34:3)PiperazinePyridoxamineGlucosamine 6-phosphatePerazineEpoxyoxophorone5-Amino-2-methoxyphenolAcridine carboxamideBiochanin AL-AcetylcarnitineS-AdenosylmethioninePC(34:4)NylidrinAllixin4-(2,6,6-Trimethyl-1,3-cyclohexadien-1-yl)-2-butanoneOctylguanidineEtoperidone(S)-LaudanosineN-Lauroylsarcosine6-Ketoestriol1,4-Butanediol diglycidyl etherNonoxynol-93-MethylglutarylcarnitinePC(34:1)3-Phosphoglyceric acidCotinine2-Piperidinone(2R,3R)-2-Aminooctadecane-1,3-diolAloxistatinEthanol, 2-(pentyl(5-(1-piperidinyl)(1,2,4)triazolo(1,5-a)pyrimidin-7-yl)amino)-Histamine1-Pyrroline-5-carboxylic acidLysoPC(20:0/0:0)PC(34:2)EplerenoneAminophenazone5'-DeoxyadenosineN,N'-Dibenzhydrylethane-1,2-diamineGenkwanin1-PyrimidinylpiperazineHerniarin3-hydroxyoctanoyl carnitineErianinGamma-linolenyl carnitineTripdiolidePyrrolidine4,5-Dimethyloxazole2-(2-Nitroimidazol-1-yl)-n-(3,3,3-trifluoropropyl)acetamideAcebutololTasquinimod9-beta-d-Arabinofuranosylguanine7alpha,8alpha-Dihydroxycalonectrin1,4-Pentadien-3-one2-Methylfuran2-trans,4-cis-DecadienoylcarnitineNorvalineGliclazidedelta-ValerolactoneDaidzein3-(1-Pyrrolidinyl)-2-butanonefalseMulti-omics Analysis of ACAD11-mediated Lipid Metabolic Reprogramming in the Prognosis of Clear Cell Renal CellClear cell renal cell carcinoma (ccRCC) is pathologically characterized by profound intracellular lipid droplet accumulation. To explore the dysregulated lipid metabolic network and identify crucial drivers, an integrated transcriptomic and untargeted metabolomic analysis was conducted. In this study, metabolism-related differentially expressed genes (mDEGs) were screened from the TCGA-KIRC dataset and validated in an independent cohort of 11 paired clinical ccRCC specimens using single-sample gene set enrichment analysis (ssGSEA), confirming the widespread suppression of lipid metabolic pathways. Weighted gene co-expression network analysis (WGCNA) integrated with transcriptomic profiling identified ACAD11 as a core metabolic hub gene. Downregulation of ACAD11 at both transcript and protein levels was validated across clinical stages, WHO/ISUP grades, and tissue microarrays via immunohistochemistry (IHC). Liquid chromatography-mass spectrometry (LC-MS)-based untargeted metabolomics was performed on clinical ccRCC tissues and matched adjacent non-tumor controls to capture the ACAD11-associated metabolic landscape. Multi-omics integration demonstrated that ACAD11 deficiency blocks fatty acid $\beta$-oxidation, leading to the pathological accumulation of multiple acylcarnitines. This dataset provides liquid chromatography-mass spectrometry (LC-MS) raw data for ccRCC metabolic profiling.2026-08-312026-08-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