Metabolite annotation and identification were performed using MS-DIAL (version 4.9.221218). Detected features were matched against the Personalbio Next-Generation Metabolomics Database (PSNGM), which integrates an in-house authentic standard library, mzCloud, LIPID MAPS, the Human Metabolome Database (HMDB), MassBank of North America (MoNA), NIST 2020 MS/MS spectral libraries, and an AI-predicted MS/MS spectral library. Identification parameters included an MS1 tolerance of 0.01, an MS2 tolerance of 0.05, smoothing level of 3, minimum peak height of 10,000, minimum peak width of 5, mass slice width of 0.05, and an identification score cut-off of 70. Metabolite annotations included compound name, molecular formula, m/z, retention time, InChIKey, matching score, HMDB identifier, KEGG identifier, compound classification, and reference ion information where available.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["Chromatographic separation was performed using a Thermo Scientific Vanquish Flex ultra-high-performance liquid chromatography (UHPLC) system equipped with a Waters ACQUITY UPLC HSS T3 column (100 Å, 1.8 μm, 2.1 mm × 100 mm). The column temperature was maintained at 40 °C and the autosampler temperature was maintained at 8 °C. The flow rate was 0.4 mL/min and the injection volume was 2 μL. Mobile phase A consisted of water containing 0.1% formic acid, and mobile phase B consisted of acetonitrile containing 0.1% formic acid. The gradient was as follows: 0–1.0 min, 5% B; 1.0–4.7 min, increased to 95% B; 4.7–6.0 min, maintained at 95% B; 6.0–6.1 min, decreased to 5% B; and 6.1–8.5 min, maintained at 5% B.
"],"publication":["Gut-Muscle Axis Regulates Meat Quality in Lambs: Rumen Microbiota-Differentiated L-Arginine and Serotonin Signaling Mediates Muscle Lipid Remodeling."],"submitter_name":["Wei Huang"],"submitter_affiliation":["Gansu Agricultural University"],"organism_part":["blood serum"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["For metabolite extraction, 50 μL of each serum sample was transferred into a 2 mL centrifuge tube and mixed with 200 μL of pre-cooled methanol/acetonitrile (1:1, v/v). The mixture was vortexed for 30 s and incubated at -20 °C for 30 min. Samples were then centrifuged at 12,000 rpm for 10 min at 4 °C. A 200 μL aliquot of the supernatant was collected and evaporated to dryness under vacuum. For quality control (QC), 10–20 μL of the filtered extract from each biological sample was pooled to generate a representative pooled QC sample.
"],"organism":["Ovis aries"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS15419"],"author":["Wei Huang. Gansu Agricultural University. 18294737108@163.com."],"data_transformation_protocol":["Raw mass spectrometry data in Thermo Scientific .raw format were processed using MS-DIAL (version 4.9.221218). Data processing included peak detection and extraction, retention-time alignment, peak filtering, missing-value processing, and normalization. Features with more than 50% missing values within all experimental groups were filtered out. Missing values for retained features were imputed, followed by normalization to generate the processed feature abundance matrix used for subsequent quantitative and statistical analyses.
"],"study_factor":["Treatment"],"submitter_email":["18294737108@163.com"],"sample_collection_protocol":["Serum samples were obtained from 12 Tan sheep (Ovis aries), comprising six 3-month-old animals (T3 group) and six 6-month-old animals (T6 group). Serum samples were collected for untargeted LC-MS metabolomic profiling to investigate age-associated metabolic differences between the two groups.
"],"omics_type":["Metabolomics"],"study_design":["pooled quality control sample","Metabolomics","untargeted metabolomics","Ovis aries","untargeted analysis","liquid chromatography-mass spectrometry","Thermo Scientific Vanquish Flex UHPLC System","Thermo Scientific Q Exactive HF-X","blood serum","Lipidomics","experimental sample"],"curator_keywords":["pooled quality control sample","Metabolomics","untargeted metabolomics","Ovis aries","untargeted analysis","liquid chromatography-mass spectrometry","Thermo Scientific Vanquish Flex UHPLC System","Thermo Scientific Q Exactive HF-X","blood serum","Lipidomics","experimental sample"],"mass_spectrometry_protocol":["Mass spectrometric analysis was performed using a Thermo Scientific Q Exactive HF-X high-resolution mass spectrometer controlled by Xcalibur software (version 4.7, Thermo Scientific). Data were acquired in data-dependent acquisition (DDA) mode using both positive and negative ionization modes with a heated electrospray ionization (HESI) source. The spray voltage was 3.5 kV, sheath gas was set to 40 arbitrary units, auxiliary gas was set to 10 arbitrary units, the capillary temperature was 320 °C, and the auxiliary gas heater temperature was 300 °C. Full MS scans were acquired over an m/z range of 70–1000 at a resolution of 60,000, with AGC Target set to Standard and a maximum injection time of 100 ms. The 10 most intense precursor ions were selected for MS/MS fragmentation. Dynamic exclusion was set to 4 s. MS/MS spectra were acquired at a resolution of 15,000 using higher-energy collisional dissociation (HCD) with a normalized collision energy of 30%, AGC Target set to Standard, and maximum injection time set to Auto. Before analysis of biological samples, 2–4 pooled QC injections were used for system equilibration, and one QC sample was injected every 6–12 biological samples during acquisition.
"],"metabolite_name":["cytarabine","LysoPC(20:3(8Z,11Z,14Z)/0:0)","Caprolactam","N6-METHYLLYSINE","2-(Ethoxymethyl)-1h-Imidazo[4,5-C]quinolin-4-Amine","N-lauroylethanolamine","PC(P-15:0/0:0)","L-Histidine","Prolinamide","Eugenol,98% (stabilized with TBC)","1-[(3,5-dimethylisoxazol-4-yl)sulfonyl]piperidine","(9S,10E,12Z,15Z)-9-Hydroperoxy-10,12,15-octadecatrienoic acid","PC(14:0/20:4(5Z,7E,11Z,14Z)-OH(9))","PC(16:0/0:0)","Flumecinol","ESTRADIOL-17ALPHA","(3alpha)-Lup-20(29)-ene-3,28-diol","Cyclopentylamine","5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid","Proline-hydroxyproline","Hydroxyprolyl-Isoleucine","12-Ketodeoxycholic acid","17-Deoxyestradiol","1-stearoyl-lysophosphatidylcholine","14-methyl-5Z,9Z-pentadecadienoic acid","Glutathione","L-Theanine","N2_N2-Dimethylguanosine","N-benzyl-N-isopropyl-N'-[4-(trifluoromethoxy)phenyl]urea","Oxohongdenafil","2,3,4,5,6-Pentafluorobenzamide","(5beta,8alpha,9beta,10alpha,13alpha)-18-Methoxy-18-oxokauran-17-oic acid","cis-Tephrostachin","LysoPC(14:0/0:0)","(1S,3R,4S,5R)-4-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,3,5-trihydroxycyclohexane-1-carboxylic acid","N,N-Dimethyl-2,2-diphenylethanamine","LysoPE(0:0/18:2(9Z,12Z))","2-Decenoylcarnitine","((R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)glycine","Oleamide","isocitric acid","14(S)-HDHA","1,9-Pyrazoloanthrone","Myristamidopropyl dimethylamine","Colfosceril palmitate","Eicosapentanoic acid","(3beta,16beta,17alpha)-Androst-5-ene-3,16,17-triol","Lecanindole B","Glutamylphenylalanine","2,6-di-tert-butyl-4-(morpholin-4-ylmethyl)phenol","Stearoyl-L-carnitine","9a,11a-dimethyl-1-(5-methylhex-3-en-2-yl)-1h,2h,3h,3ah,6h,7h,8h,9h,11h-cyclopenta[a]phenanthren-7-ol","Acetylfentanyl","Fructosylvaline","LAUROYLCARNITINE","Octaethylene glycol","(2-Oxo-4-morpholinyl)acetic acid","4-oxododecanedioic acid","Metoprolol acid","OAG","(12Z)-9,10,11-trihydroxyoctadec-12-enoic acid","methyl (2S,4R,9R,10S,13R,15S)-4,15-diethoxy-17-methoxy-9-methyl-6-oxo-5,16-dioxapentacyclo[12.3.3.01,13.02,10.04,8]icos-7-ene-14-carboxylate","TRIS(3-CHLOROPROPYL)PHOSPHATE","(-)-(4S,5S,10R,20R)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde 18,20-ethyl acetal","4,4'-dimethoxy[1,1'-biphenyl]-2-carbonitrile","11.beta.-Hydroxyprogesterone","LUMICHROME","N-[(15Z)-tetracosenoyl]sphing-4-enine-1-phosphocholine","4-chloro-N~1~-(4-pyridinyl)-1,2-benzenediamine","Ulimorelin","(4R)-4-((3R,5S,7S,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid","GLYCOCHENODEOXYCHOLATE","11-hydroxy-12-chloro-octadecanoic acid","N-(2-AMINOETHYL)-1-NAPHTHYLACETAMIDE","7-trans,9-cis-octadecadienoic acid","Leupeptin","(-)-threo-sphingosine","1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid","XANTHINE","3-Deoxyestrone","Monoethyl phthalate","2-Hydroxypurine","Linoleic acid","4-{[5-(7-hydroxy-5,5,8a-trimethyl-2-methylidene-decahydronaphthalen-1-yl)-3-methylpentyl]oxy}-4-oxobutanoic acid","methyl 1-methylpiperidine-3-carboxylate","Myoseverin","PC(P-16:0/20:5(5Z,8Z,10E,14Z,17Z)-OH(12))","[3-[2-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-5-oxo-2H-furan-2-yl] tert-butyl carbonate","DL-3-Me-Phe-OH","LysoPC(20:2(11Z,14Z)/0:0)","Dodecanamide","(6S)-6-[(1S,2R)-1,2-dihydroxypentyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one","N1-isopropyl-2-(phenylthio)benzamide","(2E)-Undec-2-enoylcarnitine","4-Methylumbelliferyl acetate","Docosahexaenoic acid","(4-chloro-1-ethyl-1H-pyrazol-3-yl)methylamine","N-(1,3-benzodioxol-5-ylmethyl)benzenesulfonamide","(1R,2R,4aR,8aS)-1-[2-(3-Furyl)ethyl]-2,4a,5-trimethyl-1,2,3,4,4a,7,8,8a-octahydro-1-naphthalenecarboxylic acid","Palmitoleyl homoserine lactone","INDOLE","L-Acetopine","DOA","14-hydroxy-3-isopropyl-6,14-dimethyl-13-oxatetracyclo[7.4.1.01,7.07,11]tetradec-2-en-12-one","Mesaconine","1-(5-hydroxy-5-methylhex-3-en-2-yl)-9a,11a-dimethyl-1h,2h,3h,3ah,3bh,4h,5h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-one","Zizyberanalic acid","gamma-Glutamylleucine","Epitestosterone glucuronide","Virosecurinin","Pleuromutilin","hexamethylcyclotrisiloxane","(2R,3R,4S,5S,6R)-2-[(E)-5-[(1R,4aS,5S,6R,8aS)-6-hydroxy-5,8a-dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]-3-methylpent-2-enoxy]-6-(hydroxymethyl)oxane-3,4,5-triol","(+)-Lepadin D","Abietic acid","2-Dodecenoylcarnitine","2-[(1-ethyl-1H-1,2,3,4-tetraazol-5-yl)sulfanyl]-1-(4-phenylpiperazino)-1-ethanone","trimethylglycine","Phenylacetaldehyde","(1r,3s,4s,7s,8r,10r)-8-ethyl-3-(prop-2-en-1-yl)-10-propyl-11-azatricyclo[5.3.1.04,11]undecane","Stearolic acid","benzyl alcohol","(-)-O-Desmethyl Tramadol","1-AMINOCYCLOPROPANE-1-CARBOXYLATE","Guanine","Furoeremophilone 1","Chlorin E6","Fructoselysine","3-Oxooctanoylcarnitine","KYNURENINE","Petroselinic acid","3-[11-ethyl-16-(hydroxymethyl)-12,17,21,26-tetramethyl-4-oxo-7,23,24,25-tetraazahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1(23),2(6),5(26),8,10,12,14,16,18(24),19-decaen-22-yl]propanoic acid","DL-Norleucine","isosteviol","(15Z)-9,12,13-Trihydroxy-15-octadecenoic acid","Myriocin","4-Phenyl-4-piperidinocyclohexanol","L-Hexanoylcarnitine","14:4(2E,4E,8E,10E)(4Me,6Me[S],12Me[S])","Desogestrel","Dibutyl (alpha-hydroxybenzyl)phosphonate","Glutamylvaline","(R)-palmitic monoisopropanolamide","b-Dihydrotetrabenazine","Pentadecanoic Acid","bis-desmethoxycurcumin","14-(2,3-dihydroxy-4-methyloxan-2-yl)-28-hydroxy-35-(hydroxymethyl)-5,7,9,19,29-pentamethyl-13,17,38,39,40,41,42,43-octaoxaoctacyclo[31.4.1.11,35.12,5.120,24.124,27.129,32.012,16]tritetraconta-8,10-diene-18,31-dione","Catharanthine","DEOXYCYTIDINE","Mirtazapine","Stearic acid","N-[6-Azanyl-1-Butyl-2,4-Bis(Oxidanylidene)pyrimidin-5-Yl]-N-Methyl-Benzamide","7,9-bis(acetyloxy)-4,5-dihydroxy-4,8,12,17-tetramethyl-16-oxo-15,18-dioxatetracyclo[12.4.0.01,17.03,8]octadec-12-en-2-yl acetate","Leucyltryptophan","13-cis Retinol","N-Methyl-L-asparagine","Terbinafine","N-(m-Methoxybenzyl)hexadecanamide","PC(15:0/20:5(5Z,8Z,11Z,14Z,17Z))","taurolithocholic acid","N,N-DIMETHYL-ARGININE","1-Linoleoyl glycerol","2-Iminothiolane","Dodecyltrimethylammonium","Taurochenodeoxycholic acid","L-Glutamate","ent-kaur-16-en-19-oic acid","Ecgonine methyl ester","Tyr-gly-gly","Ile-val","[9-[(E)-3-Acetyloxy-4-methylhex-4-en-2-yl]-12-hydroxy-3-(2-hydroxypropan-2-yl)-10-methoxy-6a,12b-dimethyl-8,11-dioxo-1,2,3,4a,5,6,12,12a-octahydropyrano[3,2-a]xanthen-1-yl] acetate","Isobutyryl-carnitine","7-Hexadecenoylcarnitine","Rumenic acid","PC(18:0/18:1(12Z))","SEROTONIN","Plakotenin","Methyl linoleate","O-Glutarylcarnitine","Oleoyl-carnitine","Kirenol","Tamsulosin","Mesalazine","4-(1-adamantyl)-2-methyl-1,3-thiazole","6-HYDROXYNICOTINATE","15-Deoxy-.DELTA.12,14-prostaglandin D2","Pinolenic acid","2-Ethoxy-2'-ethyloxanilide","Epothilone C","PC(14:0/20:3(5Z,8Z,11Z))","12-epi Leukotriene B4","Florbenazine","BETAINE","METHYL OLEATE","5-(4-carboxy-3-methylbutyl)-5,6,8a-trimethyl-3-oxo-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid","PC(P-17:0/0:0)","N-Acetylsphingosine","(4E,8E,10E-d18:3)sphingosine","Pirbuterol","asn-val-arg","4,6-CHOLESTADIEN-3-ONE","hexadecanoyl-l-homoserine lactone","1-stearoyl-2-linoleoyl-sn-glycerol","Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate","Docosatrienoic acid","methyl 9,10-Epoxy-11,13-docosadiynoate","N-(1-Deoxy-1-fructosyl)isoleucine","N-(6-{4-[3-(trifluoromethyl)pyridin-2-yl]piperazino}pyridin-3-yl)thiophene-2-carboxamide","Aspergillitine","PC(O-15:0/0:0)","1,1,3,3-Tetraethoxypropane","LysoPC(20:4(8Z,11Z,14Z,17Z)/0:0)","fencibutirol","n-[(2e)-3-(2-imino-1,3-dihydroimidazol-4-yl)prop-2-en-1-yl]-1h-pyrrole-2-carboxamide","N2,N5-Diacetylornithine","Methyl L-serinate","Butenylcarnitine","2-Hydroxyisovalerylcarnitine","N,N-Didemethyl orphenadrine","7-{[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]oxy}chromen-2-one","ACARBOSE","Arachidonoylcarnitine","2,4-di-tert-butyl-6-[(dimethylamino)methyl]phenol","LysoPC(20:5(5Z,8Z,11Z,14Z,17Z)/0:0)","(12S,13R)-5,10-Dimethyl-8,14,16-trioxatetracyclo[10.2.2.0~1,13~.0~7,11~]hexadeca-4,7(11),9-trien-15-one","7-Methylhypoxanthine","4-Hexenoylcarnitine","14-pentadecenoic acid","CYCLOPENTANONE","4,4'-Diisocyanatodicyclohexylmethane","Myristoyl-carnitine","N-Methyldioctylamine","Cholesterol","8-Methyldecanoylcarnitine","L-CARNITINE","L-alpha-Amino-1H-pyrrole-1-hexanoic acid","Pentaethylene glycol","Reichstein's Substance V","(all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid","4'-O-Methylequol","1,1-Dibutyl-3-(3-chloro-2-methylphenyl)urea","(3beta,16alpha,17alpha)-Androst-5-ene-3,16,17-triol","2-Phenyl-1H-indol-1-ol","CRYPTOSTROBIN(P)","Victoria Pure Blue BO","LysoPE(0:0/18:3(9Z,12Z,15Z))","(R)-14-Methyloxacyclotetradecan-2-one","Phloroglucinol","Glucuronolactone","L-Kynurenine","alpha-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol","5-Chloromethyl-1H-tetrazole","Minoxidil","N,N-Bis(2-hydroxyethyl)dodecanamide","1-stearoyl-sn-glycero-3-phosphoethanolamine","6-Hydroxy-1H-indole-3-acetamide","Heptadecanoyl Ethanolamide","LysoPC(P-18:0)","Diaveridine","Diisodecyl phthalate","PC(P-18:0/20:5(5Z,8Z,11Z,14Z,16E)-OH(18))","(1R,4aS,5R,8aS)-5-(5-hydroxy-3-methylpentyl)-1,4a-dimethyl-6-methylidene-decahydronaphthalene-1-carboxylic acid","PC(P-18:1(9Z)/18:2(10E,12Z)+=O(9))","16-Heptadecyne-1,2,4-triol","Cyclohexanamine","Clopenthixol decanoate","CORTISOL","Octinoxate","1-Methylimidazole","4,2',3',4'-Tetrahydroxychalcone","2-oxo-nonadecanoic acid","1-octadecanoyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine","Guanidinoacetic acid","Trp-Phe","7-Amino-4-hydroxy-2-naphthalenesulfonic acid","(2E)-4-Hydroxytetradec-2-enoylcarnitine","Enterolactone","21-Deoxycortisol","R-Palmitoyl-(2-methyl) ethanolamide","(2E,4Z)-Decadienoylcarnitine","methyl (2S,4R,9R,10S,13R)-4,15-dihydroxy-17-methoxy-9-methyl-6-oxo-5,16-dioxapentacyclo[12.3.3.01,13.02,10.04,8]icos-7-ene-14-carboxylate","o6-Benzyl-8-oxoguanine","4-Fluoro PV8 piperidine analog","DECANOYLCARNITINE","Myristamide","URSODEOXYCHOLATE","C3-Carnitine","PC(15:0/18:3(6Z,9Z,12Z))","2-piperidino-5-(trifluoromethyl)aniline","Agonandric acid","5-[3-(ethoxycarbonyl)-4-piperidinoanilino]-3,3-dimethyl-5-oxopentanoic acid","L-(+)-Citrulline","1-Acetamidocyclopentanecarboxylic acid","PC(O-20:0/17:2(9Z,12Z))","(1R,10S)-10-Hydroxy-1,6,6-Trimethyl-10-(2-Oxopropyl)-1,2,6,7,8,9-Hexahydrophenanthro[1,2-B]Furan-11(10H)-One","13Z-Hexadecen-11-yn-1-ol","cis-5-Tetradecenoylcarnitine","Mycosporine Serinol","3-METHYLBENZYLSUCCINIC ACID","B-Raf inhibitor","Pachyclavulariolide M","19-Norandrosterone glucuronide","dihydralazine","3-Hydroxyoctadecanoylcarnitine","Stearamide","Resolvin D2","1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine","Methylcholate","Nitroguanidine","N,N-dimethyl-Safingol","(2,4-Dimethylcyclohexyl)methyl acetate","Valtrate","(10Z)-Heptadec-10-enoylcarnitine","15-Hexadecynoic acid","N-Benzyl-L-isoleucine methyl ester","Ergothioneine","LATIFOLICININ C ACID","MONOLINOLENIN","Hemigossypol","Sesamol","Echinocystic acid","Sitosterol","(2E)-4-Hydroxy-4-{4-hydroxy-2-[(1E)-6-hydroxy-1-hepten-1-yl]cyclopentyl}-2-butenoic acid","1-pentadecanoyl-sn-glycero-3-phosphocholine","1-Dodecyl-2-pyrrolidinone","Metanilanilide","Glaucarubin","PC(P-16:0/20:4(5Z,7E,11Z,14Z)-OH(9))","gamma-Glutamylglutamine","Carteolol","Glycine anhydride","Vinflunine","1H-Indole-2,3-dione","(5'-(but-3-en-1-yn-1-yl)-[2,2'-bithiophen]-5-yl)methyl acetate","6-Bromo-3-formylindole","1-icosanoyl-sn-glycero-3-phosphocholine","7-methylpyrimido[4,5-d]pyrimidin-4-amine","L-Glutamine","2-Chloro-6-methylbenzoic acid","(15Z)-N-(2-Hydroxyethyl)-15-tetracosenamide","PC(P-18:0/18:2(10E,12Z)+=O(9))","8-[(2R,3S)-3-(8-Hydroxyoctyl)oxiran-2-yl]octanoylcarnitine","trans-4-Aminocyclohexanecarboxylic acid","Homatropine","L-Isoleucine","CYTIDINE","ATHPINACA isomer 1","7-Hydroxyabieta-8,11,13-trien-18-oic acid","Crucigasterin 277","Adenosine monophosphate (AMP)","N-Oxo-3-pyridinecarboxamide","N(alpha)-methyl-L-lysine","Daurisoline","Hydrocodone","Phosphorylcholine","Exemestane","3-hydroxydodecanoyl carnitine","emetine","2,2,6,6-Tetramethylpiperidin-1-ol","2-Mercaptobenzothiazole","LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","ETHYL PALMITOLEATE","ODYA","Tetranor-PGDM","2-Hydroxy-5-octenoylcarnitine","(3S,4E,15Z)-Docosa-4,15-Dien-1-Yn-3-Ol","9-oxo-7E-hexadecenoic acid","2-((4R)-4-((3R,5S,7R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonic acid","Lauryldimethylamine oxide","5-O-Methylvisamminol","Baccatin","(S,S)-formoterol","1-[(9Z)-octadecenoyl]-2-tetradecanoyl-sn-glycero-3-phosphocholine","Adenylthiomethylpentose","LysoPC(22:5(7Z,10Z,13Z,16Z,19Z)/0:0)","D-Ornithine","Di-deacetyl adrogolide","DNP-DL-Methionine","Monoelaidin","(2S,3R)-3-Methyloxiran-2-ylphosphonic acid","(2E,4E)-Tetradecadienoylcarnitine","DL-N-Acetyltryptophan","Phosphocholine","Oxalicine B","5-(hydroxymethyl)-4-methoxy-2,5-dihydrofuran-2-one","2-Cyclotetradecen-1-one","1-Hydroxypyrene","LysoPC(18:3(9Z,12Z,15Z)/0:0)","Juniperic acid","4-hydroxy-6,9-dimethyl-3-methylidene-2H,3H,3aH,4H,5H,6H,6aH,7H,8H,9bH-azuleno[4,5-b]furan-2,8-dione","24S-Hydroxy-cholesterol","Taurodeoxycholic Acid","1-METHYLADENOSINE","CORTEXOLONE","DEOXYCARNITINE","DEOXYCHOLATE","Penaresidin B","Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-(phenylmethylene)-","Ribociclib","Tributyl phosphate","Oxyresveratrol","4-Hydroxy-5-(5-hydroxypentan-2-yl)-6-methyl-3-methylidene-3a,4,7,7a-tetrahydro-1-benzofuran-2-one","3-[4-(3-Trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one","t17:0 phytosphingosine","4-Cyclopropyl-1H-imidazol-2-amine","Quinoline","N-Acetylvaline","6-dehydrotestosterone","Cediranib","LysoPC(P-18:1(9Z)/0:0)","trans-Vaccenic acid methyl ester","I-SAP","Musanolone D","Ethyl 1-aminocyclopentanecarboxylate","PC(O-12:0/2:0)","N2-Methylguanosine","L-Proline","PIPECOLIC ACID","16-heptadecenoic acid","20 beta-Dihydrocortisol","5-beta-Dihydrotestosterone","(Z)-14-Methyl-6-pentadecenoic acid","Phakellistatin-5","Adipoyl-L-carnitine","2,3-Dinor-11beta-prostaglandin F2alpha","Polyveoline","2,2,6,6-Tetramethyl-4-piperidinol","3-Oxo-5beta-chola-7,11-dien-24-oic Acid","N-ACETYL-DL-LEUCINE","PC(O-16:0/3:0)","2-Hydroxyquinoline","Stearoylethanolamide","Fluocinolone Acetonide","saxitoxin","Tresperimus","Azadiradione","(6Z)-Pentadec-6-enoylcarnitine","Linoleyl carnitine","N-Methylproline","N-(4-Fluorophenyl)-4,5-dimethyl-6-[(1S)-1-methyl-3,4-dihydro-1H-isoquinolin-2-YL]pyrimidin-2-amine","benzotript","Tridecanoylcarnitine","Posaconazole","7Z,11Z,14Z-Hexadecatrienoic acid","Octyl hydrogen phthalate","deltaline","Palmitylethanolamide","(2R,3R,4S,5S,6R)-2-{[(2E)-4-ethenyl-2,5-dimethylhexa-2,5-dien-1-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol","1-(2-Hydroxyethyl)-2,2,6,6-tetramethyl-4-piperidinol","(2S)-2-Hydroxyhexadecanoylcarnitine","phe-ile","9-Nitrooleate","4'-N-desmethylolanzapine","4-Methyloctanoylcarnitine","1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholine","Bis-A-tda","Biliverdin","12-Methyl-8-oxapentacyclo[14.2.1.0~1,13~.0~4,12~.0~5,9~]nonadeca-5(9),6-dien-17-one","N,N-Dimethylsphingosine","2-hydroxy-9Z,12Z-Octadecadienoic acid","3-(dimethylamino)-1-(5-methyl-3-phenyl-4-isoxazolyl)-2-propen-1-one","5-Carboxy-cytosine","Palmitoyl sphingomyelin","N-Me-Leu-OH","4-[5-(Trifluoromethyl)-1H-pyrazol-3-yl]pyridine","Dimethylguanidino valeric acid","Sumarotene","D-Erythro-sphingosine 1-phosphate","5b-Androstan-3b,17b-diol","3-hydroxydecanoyl carnitine","2-Amino-4-chloro-3,5-dimethylphenol","(R)-lamenallenic acid","(1s,2s,3r,5r,8s,9z,13s,14s,15s,17s,19r)-15-(acetyloxy)-2-hydroxy-5,10,14,19-tetramethyl-6-oxo-4,7,18-trioxapentacyclo[12.5.0.03,5.03,8.017,19]nonadec-9-en-13-yl propanoate","Delmopinol","Huperzine A","Schisanhenol","8,11-Heptadecadienal","2,5-Dimethyl-4-pyrimidinamine","Homovanillyl alcohol","6Z-Heptadecen-2-one","URSOCHOLIC ACID","linoleoyl glycine","3-Methylglutaconic acid","LysoPC(0:0/20:4(5Z,8Z,11Z,14Z))","3-[18-(2-Carboxyethyl)-8,13-diethyl-3,7,12,17-tetramethyl-21,22,23,24-tetrahydroporphyrin-2-yl]propanoic acid","L-Tyrosine","(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(propan-2-yloxy)oxane-3,4,5-triol","Dihomo-gamma-linolenic acid ethyl ester","Octyl acetate","Fomepizole","Urapidil","LysoPC(18:4(6Z,9Z,12Z,15Z)/0:0)","methyl 5-({[3-(tert-butyl)-1-(4-fluorobenzyl)-1H-pyrazol-5-yl]carbonyl}amino)-2-morpholinobenzoate","GLYCOCHOLATE","Phenylalanylphenylalanine","5-Acetamido-4-oxohexanoic acid","Docosahexaenoic acid ethyl ester","(R)-3-hydroxybutyrylcarnitine","Benzonatate","gamma-Glutamyltyrosine","methyl 3,4,5-trihydroxycyclohex-1-ene-1-carboxylate","PC(P-14:0/0:0)","Cryptophycin 176","LysoPE(20:4(5Z,8Z,11Z,14Z)/0:0)","4(1H)-Pyridinone, 2-ethyl-3-hydroxy-1-(2-hydroxyethyl)-","4-pyridin-2-ylpyrimidin-2-amine","L-METHIONINE","OCTANOYLCARNITINE","carglumic acid","(7Z,10Z)-Hexadecadienoylcarnitine","PANTOLACTONE","3,4-Methylenedioxycinnamaldehyde","Cannabinodiol","4-Aminobenzoic acid","Methyl (4S,5R,9R,13R)-5,9-dimethyl-10,14-dioxotricyclo[11.2.1.0~4,9~]hexadec-1(15)-ene-5-carboxylate","(1r,9r,10s)-9-butyl-6-imino-10-methyl-5,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),7-dien-9-ol","methacholine","3-Formylindole","Carboxybupranolol, 4-chloro-3-[3-(1,1-dimethylethylamino)-2-hydroxy-propyloxy]benzoic acid","1,2-Dioleoyl-sn-glycerol","PC(17:1(10Z)/0:0)","Hydroxyproline","LysoPC(16:1(9Z)/0:0)","2-(4,6-Dimethyl-2-pyrimidinyl)-1-(4-methoxyphenyl)guanidine","PC(15:0/18:2(9Z,12Z))","Piperine","ADENOSINE-MONOPHOSPHATE","21,25,28-trihydroxy-9-methyl-11-oxa-22,27-diazahexacyclo[24.2.1.05,17.07,15.08,13.010,12]nonacosa-1(28),3,19,21-tetraene-2,29-dione","Encecalin","Amifloxacin","Creatinine","(5r,8s)-5-isopropyl-1-methoxy-3,8-dimethyl-5,6,7,8-tetrahydronaphthalene","PHENETHYLAMINE","3alpha,6beta,7beta,12alpha-Tetrahydroxy-5beta-cholan-24-oic Acid","Tridec-7-enoylcarnitine","6-Hydroxy-1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-yl benzoate","Hexaethylene glycol","tetranor-12(R)-HETE","Heliotridine","PALGLY","11,13-Dihydroxy-4-methyl-4,5,6,7,8,9-hexahydro-2H-3-benzoxacyclododecine-2,10(1H)-dione","Stiripentol","1,3-dimethyl-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-4-ol","Triethyl phosphate","5-CHLORO-AB-PINACA","5-[(1-Iminoethyl)amino]-2-aminopentanoic acid","Decamethylcyclopentasiloxane","falcarindiol","CREATINE","4-hydroxy-6-[2-(2-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)ethyl]oxan-2-one","Pivaloylcarnitine","PC(O-18:1(10E)/2:0)","1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.02,6.06,22.07,12.014,22.016,21]pentacosa-7,9,11,16,18,20-hexaen-3-yl]hexa-2,4-dien-1-one","1-(hept-3-en-2-yl)-9a,11a-dimethyl-1h,2h,3h,3ah,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-ol","2,5-Dimethyl-1,3-thiazole-4-carboxylic acid","1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine","5-Aminovaleric acid betaine","PC(18:3(10,12,15)-OH(9)/15:0)","Diethyl 1-methyl-1H-imidazole-4,5-dicarboxylate","CHOLATE","Arginylasparagine","N-Benzyl-3-[(2S,5aS,8aR)-6-(1H-imidazol-2-ylmethyl)-1-methyl-5-oxodecahydropyrrolo[3,2-E][1,4]diazepin-2-yl]propanamide","Isoquinoline","L-Lysine","(+/-)-Gingerol","C17 Sphingosine","Montiporyne C","2-[(Z)-[(4Z)-4-(Diaminomethylidenehydrazinylidene)hexan-3-ylidene]amino]guanidine","2-(METHYLTHIO)ACETOPHENONE","Deoxyspergualin","Palmitamide","5-hydroxy-4-[3-(2-hydroxypropan-2-yl)oxiran-2-yl]-1-methyl-7-oxabicyclo[4.1.0]hept-3-en-2-one","5-Amino-3,4-dihydro-1(2H)-isoquinolinone","4-Oxo-4-[(3-oxo-2-decanyl)amino]butanoic acid","Hexadeca-7,10,13-trienoic acid","(3beta,6alpha,9xi,12beta,20Z)-3,12-Dihydroxydammara-20(22),24-dien-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside","9,10-Epoxy-18-hydroxy-octadecanoic acid","AB-CHMINACA metabolite M6","AB-CHMINACA metabolite M4","Triphenylphosphine oxide","allopregnane-3,20-diol","SMPC","3-Decenoylcarnitine","N-(3,12-Dihydroxy-24-oxocholan-24-yl)glycine","Trans-petroselinic acid ethanolamide","Oleoyl Ethyl Amide","Thiazine","Tryptophyl-Glutamate","17beta-Trenbolone","APM","(5S)-5-hydroxy-1,7-diphenylheptan-3-one","6-hydroxysphingosine","Prolylleucine","Raddeanin A","4'-Hydroxyflurbiprofen","N-Ethyl-N-methylcathinone","5alpha-cholest-7-en-3beta-ol","PC(18:2(2E,4E)/0:0)","Phe-Trp","1-Methylpyrrolidine","gly-gly-phe","Muscone","2,2,4-Trimethyl-1,3-pentadienol diisobutyrate","Palmitoyl-carnitine","LysoPC(22:4(7Z,10Z,13Z,16Z)/0:0)","4-oxo-4-(5,6,7,8-tetrahydronaphthalen-1-ylamino)but-2-enoic acid","(2alpha,3alpha,5xi,9xi,18xi)-2,3,19-Trihydroxyurs-12-en-28-oic acid","doxercalciferol","PC(18:0/16:2(2E,4E))","C-8 Ceramide-1-phosphate","[2R-(2alpha,4aalpha,5alpha,8abeta)]-5-Bromodecahydro-a,a,4a-trimethyl-8-methylene-2-naphthalenemethanol","(E,E)-5-Hydroxy-1,7-Diphenyl-4,6-Heptadien-3-One","Ricinoleic acid","Citrinin","Hederagenin","(2R,3R,4S,5S,6R)-3-(acetyloxy)-2-[(acetyloxy)methyl]-5-(hexanoyloxy)-6-[(2S,3R)-2,3,4-trihydroxybutoxy]oxan-4-yl tetradecanoate","(1r,2s,10s,12s,13s,14s)-12-hydroxy-7,14,18-trimethoxy-6,17,21-trimethyl-5,8,16,19-tetraoxo-11,21-diazapentacyclo[11.7.1.02,11.04,9.015,20]henicosa-4(9),6,15(20),17-tetraen-10-yl (2z)-2-methylbut-2-enoate","peiminine","Linoleamide","Methyl deoxycholate","1-Carboxy-6-Hydroxy-3,4-Dihydro-Beta-Carboline","Niacinamide","N,N-Diethyldodecanamide","3S,7Z-hydroxytetradecenoylcarnitine","CORTICOSTERONE","Phenylacetylglycine","12,14-bis(acetyloxy)-3,16-dihydroxy-4,9,13,17-tetramethyl-5-oxo-6-oxatricyclo[11.4.0.03,7]heptadec-8-en-2-yl acetate","GUANOSINE","17-ODYA","(1R,2S,5aR,5bR,7aS,10R,12bR)-2-Hydroxy-10-isopropenyl-3,3,5a,5b,12b-pentamethyloctadecahydrodicyclopenta[a,i]phenanthrene-1,7a(1H)-dicarboxylic acid","1-O-Hexadecyl-2-O-(2E-butenoyl)-sn-glyceryl-3-phosphocholine","1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine","Methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate","15-methyl-phytosphingosine","N-[3-(Dimethylamino)propyl]propanamide","(24S)-7alpha,24-dihydroxycholest-4-en-3-one","protionamide","Neosolaniol","taurocholic acid","mollamide E","sarmentogenin","Erythrodiol","Phytosphingosine","PC(15:0/18:1(11Z))","Isoleucylhydroxyproline","(11E,15Z)-9,10,13-Trihydroxy-11,15-octadecadienoic acid","(1S,2R,9R,11R,12R,15R)-11-Hydroxy-2,6,9,15-tetramethyl-13-oxatetracyclo[10.2.1.0~2,10~.0~5,9~]pentadeca-4,6-diene-3,8,14-trione","[1-(5-Fluoropentyl)-2-methyl-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone","1-Naphthyl isocyanate","Octyl phenylacetate","Gibberellin A52","4'-Hydroxy-5,5'-diisopropyl-2,2'-dimethyl-3,4-biphenylquinone","Mephenytoin","LysoPC(18:2(9Z,12Z)/0:0)","Hypoxanthine","Bis(2-ethylhexyl) amine","1-palmitoyl-2-myristoyl-sn-glycero-3-phosphocholine","L-Arginine","1-Pyrenecarboxaldehyde","15-OxoEDE","PC(16:0/18:3(9Z,12Z,15Z))","Meptin","(3E,5S,8R,11E,13S,16R)-5,13-dihydroxy-8,16-dimethyl-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione","7-Ethyl-3,11-dimethyl-1,3Z,6E,10E-tridecatetraene","dextilidine","N6,N6,N6-Trimethyl-L-lysine","Methyl palmitate","L-alpha-Glycerylphosphorylcholine","beta-D-glucosaminyl-(1->4)-D-glucosamine","(-)-Folicanthine","8-heptadecynoic acid","Arachidonyl alcohol","19-Oxoandrostendione","1-Oleoyl-sn-glycero-3-phosphocholine","Cortisone","Kanzonol I","(E)-3,10-Dihydroxy-4,9-dimethyldodec-6-enedioic acid","Isohyodeoxycholic acid","Gallocatechin gallate","Ouabain","1-Methylpyrene","3,7,12-Trihydroxycholan-24-oic acid","12-Methyltetradecanoylcarnitine","Caffeine","4-Hydroxybenzoylcholine","12-Acetoxypimara-7,15-dien-18-oic acid","Quinaldine","2-Methyl-1-propylamine","5-METHYLCYTOSINE","4-Hydroxybenzoic acid","Heptaethylene glycol","PC(16:0/18:2(2E,4E))","Laurixamine","s-Triazine, 2-amino-4-((4-methyl-1-piperazinyl)methyl)-6-piperidino-","N-(icosanoyl)ethanolamine","asperlactone","Theophylline","2-[(2R,4aS,7R)-7-Hydroxy-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid","4-Tetradecanamidobenzylphosphonic acid","3-Oxononanoylcarnitine","Leucyl-leucine","5H-Indazole-5,5-dicarboxylicacid, 1,2,3,4,6,7-hexahydro-3-oxo-","PON-PC","Oleoyl ethanolamide","Benzoylhypaconine","Ethyldiethanolamine","Tridemorph","flexilarin J","Thyroxine","Pyroglutamic acid","4-Ethoxycoumarin","(-)-Stolondiol","{[(5s)-5-hydroxy-5-(hydroxymethyl)-2-methoxy-3-(methylimino)cyclohex-1-en-1-yl]amino}acetic acid","4-methyl-5-oxo-2-pentyl-2,5-dihydrofuran-3-carboxylic acid","(9Z)-9-octadecenoic acid","(Z)-(1S)-cis-tefluthrin","8-MethylHexadecanoylcarnitine","Tubipolide B","9-Oxo-ODE","Asp-Ile","AB-PINACA","L-Acetylcarnitine","Pemoline","Tauroursocholic acid","C8 ceramide","N-Phenyl-2-[4-(2-pyridinyl)-1-piperazinyl]acetamide","(10z)-5-ethyl-1-oxa-4-azacyclopentadec-10-en-15-one","Thalirugidine","5-OxoETE","Octenoyl-carnitine","2-Methyl-4-isothiazolin-3-one","Dibutyl phthalate","Danofloxacin","9-N-methyl-8-methoxy-manzamine A","(4-chloropyridin-3-yl)methanamine","1-Palmitoyl-2-hydroxy-sn-glycero-3-PE","tauroursodeoxycholic acid","2-Hydroxyundec-5-enoylcarnitine","PC(O-16:0/3:1(2E))","fenfluramine","13,14-dihydro-15-keto-tetranor Prostaglandin D2","Tanshinone I","Foeniculoside VIII","PC(22:5(4Z,7Z,10Z,13Z,16Z)/18:0)","Alfacalcidiol","Erucamide","3,5-Di-tert-butyl-4-hydroxybenzaldehyde","Cidofovir","Lyso-PAF-C16","Citroflex 2","1-Oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine","2-Tiglylcarnitine","Atglistatin","Triciribine","flonicamid","3-hydroxyoctanoyl carnitine","Dihydropyrimidine","(3br,5ar,6s,9ar,9bs)-3b,6,9a-trimethyl-1-oxo-3h,4h,5h,5ah,7h,8h,9h,9bh,10h,11h-phenanthro[1,2-c]furan-6-carboxylic acid","Methionine sulfoxide","Chamazulene Carboxylic Acid","4-Methylhexanoylcarnitine","Ethyl 3-amino-4-fluoro-1-benzothiophene-2-carboxylate","Albocyclin","Nutriacholic acid","Trans-2, 3, 4-Trimethoxycinnamate","(+)-.gamma.-Amino-.beta.-hydroxybutyric acid","PC(P-16:0/2:0)","Incensole","Miltirone","1-heptadecanoyl-sn-glycero-3-phosphocholine","1-METHYL-L-HISTIDINE","Palmitic Acid","Pyrrolidine","4-(4-Isopropylphenyl)-5-methyl-1,3-thiazol-2-amine","(2S,2'S)-3,3'-disulfanediylbis(2-aminopropanoic acid)","17-epi-nandrolone","1,2-Dihexanoyl-sn-glycerol","(R)-4-((3S,5R,6S,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid","3-(3,3-dimethyloxiran-2-yl)-1,7-dimethyl-4-methylidene-1,2,3,3a,5,6,7,8,9,9a-decahydrophenalen-2-yl acetate","p-toluamide","2-(8-Hydroxy-4a,8-dimethyldecahydro-2-naphthalenyl)acrylic acid","Ceramide (d18:1/16:0)","2'-Deoxyguanosine","N-Methyl-2-pyrrolidone","Diphenylphosphate","(1S,4aS,5R)-5-[2-(3-Furyl)ethyl]-1,4a-dimethyl-6-methylenedecahydro-1-naphthalenecarboxylic acid","3-Hydroxyadipic acid 3,6-lactone"],"additional_accession":[]},"is_claimable":false,"name":"Gut-Muscle Axis Regulates Meat Quality in Lambs: Rumen Microbiota-Differentiated L-Arginine and Serotonin Signaling Mediates Muscle Lipid Remodeling","description":"This study investigated age-associated changes in the gut-muscle axis and their potential contribution to meat quality in Tan sheep (Ovis aries). Twelve Tan sheep were divided into two age groups, including six 3-month-old animals (T3) and six 6-month-old animals (T6). Untargeted LC-MS metabolomics was performed to characterize serum metabolic profiles, and untargeted lipidomics was used to investigate lipid remodeling in longissimus dorsi muscle. In parallel, rumen microbial community profiles were analyzed to explore potential associations between microbiota-derived metabolites, host metabolism, and muscle lipid composition. Particular attention was paid to L-arginine- and serotonin-related metabolic signaling and their associations with muscle lipid remodeling and meat quality. The dataset provides mass spectrometry-based metabolomic and lipidomic profiles for investigating age-related metabolic regulation and gut-muscle interactions in Tan sheep.
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