MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/m_MTBLS15525_LC-MS_negative_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/m_MTBLS15525_LC-MS_positive_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/a_MTBLS15525_LC-MS_negative_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/s_MTBLS15525.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/a_MTBLS15525_LC-MS_positive_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PGB_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto6B_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/QC04.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto3B_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/QC03.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PGB_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto100B_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PGB_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PG14B_5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto3B_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto6B_5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto100B_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PGB_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/QC02.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto6B_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PGB_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PG14B_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PGB_5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PG14B_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PGB_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/QC01.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto3B_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto100B_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto6B_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto3B_5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PG14B_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PGB_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto3B_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto6B_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PGB_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PG14B_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto6B_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto100B_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto3B_5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PG14B_5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PG14B_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto6B_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto6B_5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto3B_1.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto100B_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/QC01.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto6B_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto100B_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto3B_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PG14B_2.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/PGB_5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PG14B_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto100B_5.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/QC02.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto6B_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto3B_3.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto100B_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/PG14B_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/QC03.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/QC04.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto3B_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/POS/Eto100B_4.zipftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525/FILES/NEG/Eto100B_5.zipprimary200OKftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15525<p>which was developed using R and based on XCMS, for feature detection, extraction, alignment, and integration. The R package and the BiotreeDB(V3.0) were applied in metabolite identification.</p>MetaboLightsPublicLiquid Chromatography MS - positive - hilicLiquid Chromatography MS - negative - hilic<p>For polar metabolites, LC-MS/MS analyses were performed using an UHPLC system (Vanquish, Thermo Fisher Scientific) with a Waters ACQUITY UPLC BEH Amide (2.1 mm × 50 mm, 1.7 μm) coupled to Orbitrap Exploris 120 mass spectrometer (Orbitrap MS, Thermo). The mobile phase consisted of (A) water containing 25 mmol/L ammonium acetate and 25 mmol/L ammonium hydroxide (pH 9.75) and (B) acetonitrile. The auto-sampler temperature was 4 ℃, and the injection volume was 2 μL.</p>Mechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration.gaolin zhengHainan Medical UniversityCerebral tissuemass spectrometry assay<p>Brain and liver tissues were processed identically. Briefly, 25 mg tissue was extracted with 500 μL methanol:acetonitrile:water (2:2:1, v/v/v) containing isotope-labeled internal standards, vortexed for 30 s, homogenized at 35 Hz for 4 min, sonicated in an ice-water bath for 5 min × 3, and incubated at −40 °C for 1 h before filtration.</p>Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS15525gaolin zheng. Hainan Medical University. zhenggaolin0602@gmail.com.<p>The raw data were converted to the mzXML format using ProteoWizard and processed with an in-house program.</p>Groupzhenggaolin0602@gmail.com<p>Cerebral tissue (after removal of the cerebellum and olfactory bulbs) and right hepatic lobe tissue were collected from five experimental groups, with five biological replicates per group for each tissue type (25 cerebral-tissue samples and 25 right-hepatic-lobe samples). Samples were immediately snap-frozen in liquid nitrogen and stored at −80 °C until metabolomic analysis.</p>MetabolomicsThermo Scientific Vanquish UHPLC Systempooled quality control sampleMetabolomicsProteoWizard msconvertMus musculusCerebral tissueuntargeted analysisThermo Scientific Orbitrap Exploris 120Etomidate AddictionNeuro-Hepatic Toxicityexperimental sampleuntargeted metabolite profilingThermo Scientific Vanquish UHPLC Systempooled quality control sampleMetabolomicsProteoWizard msconvertMus musculusCerebral tissueuntargeted analysisThermo Scientific Orbitrap Exploris 120Etomidate AddictionNeuro-Hepatic Toxicityexperimental sampleuntargeted metabolite profiling<p>The Orbitrap Exploris 120 mass spectrometer was used for its ability to acquire MS/MS spectra on information-dependent acquisition (IDA) mode in the control of the acquisition software (Xcalibur, Thermo). In this mode, the acquisition software continuously evaluates the full scan MS spectrum. The ESI source conditions were set as following:sheath gas flow rate as 50 Arb, Aux gas flow rate as 15 Arb, capillary temperature 320 ℃, full MS resolution as 60000, MS/MS resolution as 15000, collision energy: SNCE 20/30/40, spray voltage as 3.8 kV (positive) or -3.4 kV (negative), respectively.</p>HydroxyebastineTrapidilDambonitolGentamicin3,7,3',4',5'-PentamethoxyflavoneMalonyl-L-carnitinePhe-IleEdpetilineCiprofibrateTetradecadienoylcarnitine (Car(14:2))EctoineGoralatide (acetate)PantothenolErgonovine1,4-Dibutyl benzene-1,4-dicarboxylate(2E,4E,6E)-11-(1,3-Benzodioxol-5-yl)-N-(2-methylpropyl)undeca-2,4,6-trienamideTimololNipecotic acidLutein1-Methyl-3-isobutylxanthineCitrulline1-(1Z-Octadecenyl)-sn-glycero-3-phosphocholine7-Chloro-5-methyl-2H-1,4-benzothiazin-3(4H)-oneOxotetradecenoylcarnitine (Car(14:2-O))(2-Bromoethyl)(triphenyl)phosphonium cationPC(33:1)LysoPC(24:1(15Z))1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(3-chlorophenyl)-1-methyl-Diuron-desdimethyl2-[[5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylamino]-4-methylsulfanylbutanoic acidCyclopropanecarboxamide, N-[3-(2-methoxyethyl)-4,5-dimethyl-2(3H)-thiazolylidene]-2,2,3,3-tetramethyl-, [N(Z)]-2,4,6-TrimethoxypyrimidineN-(4-Nitrophenyl)-2-phenoxyacetamideNorgestimate5Z,8Z,11Z,14Z-Eicosatetraenoic acid, 3-theinylmethyl ester5-Bromo-5'-hexyl-2,2'-bithiopheneGamma-glutamyl-GlutamineArginineIsorhamnetin_3-O-[b-D-xylopyranosyl-(1->6)-b-D-glucopyranoside]5-(2-methoxyethylamino)-3H-1,3,4-thiadiazole-2-thioneGlutathione2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-olLysoPC(18:4(6Z,9Z,12Z,15Z))Threoninyl-HydroxyprolineN-Formyl-L-glutamatePC(16:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))6,7-Dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamineOxopalmitoylcarnitine (Car(16:1-O))ClauseninIsodesmosine2-Hydroxy-4-(octyloxyl)benzophenone4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanonePiperolein_BOleamideMethylergonovinePro-GluKainic acidN-Methyl-L-prolineMoxonidineN-(Deshydroxyethyl)dasatinibNicotinamide riboside (NR)Hygric acidCervonyl_carnitine7H-Benzo[de]anthracen-7-one2',7-Dihydroxy-4'-methoxy-8-prenylflavan1-O-Hexadecyl-sn-glycero-3-phosphocholine (LPC(O-16:0/0:0))Trigofoenoside_ADrostanolone propionateXanthurenic acidN-(2-Propynyl)cyclohexanamineEtomidate1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineSuccinyladenosine2-Oleoyl-1-stearoyl-sn-glycero-3-phosphoserineCyclocytidineOctaethylene glycol1-Hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineTorvoside_AHexadecadienoylcarnitine (Car(16:2))L-Glycine ether ester4(5H)-Thiazolone, 5-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-, (5Z)-N-Methylpropionamide12'-Apo-b-carotene-3,12'-diolMethylguanidine2-Docosahexaenoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine2-(5-Oxovaleryl)phosphatidylcholine4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)1H-imidazol-2-yl]benzamideBiotin-XX hydrazideOrnithine1-PhenylpyrrolidineAllocryptopineMLS000859943-01!PS(20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))[3,4,5-trihydroxy-6-(3,4,5-trihydroxybenzoyl)oxyoxan-2-yl]methyl 3,4,5-trihydroxybenzoateLPE(P-16:0)PE(19:1)7-Hydroxy-6-methoxy-3-methyl-5-(propan-2-ylidene)furo[2,3,4-de]chromen-2(5H)-oneSarcosine ethyl esterPromethazine sulfoxidePhe-Thr2-Chloro-3-chloromethyl-6-fluoroquinolineAsp-GluO-t-Butyl-L-threonine methyl esterEthyl ethoxyacetate3-methylolphenol2-Phenyl-N-(4-sulfamoylbenzyl)acetamideAdenosinePC(16:0/18:1(9Z))1,7-Dioxa-4,10-diazacyclododecane3,4-Dichloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide3,6,9,12-Tetraoxatetracosan-1-olPE(14:1(9Z)/14:0)ArborinineNeolinustatin7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-ylamineOligomycin APC(31:1)Arg-AspPC(18:0/18:1(9Z))5-Taurinomethyl-2-thiouridineCyclopassifloic_acid_CBetonicinePeimineHercynine [M]dTDP-4-acetamido-4,6-dideoxy-D-galactoseNeoacrimarine_EPseudoginsenoside RT5Fragransin_B26-Benzyl-3-butan-2-yl-9-(7-hydroxy-6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N,N-dimethyl2-Methyl-5-phenyl-1,3-thiazol-4-olPC(16:0/16:0)SphingosineGamma-glutamyl-AspartateCytidine monophosphate N-acetylneuraminic acidPG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Threonine4-Imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-2-Amino-6-(methylsulfanyl)-3,5-pyridinedicarbonitrile2,6-Diamino-4-(4-nitrophenyl)-4H-thiopyran-3,5-dicarbonitrileLys-LeuN-Acetyl-arginineTelmisartanPhenol, 2-[4-[(3,5-dichlorophenyl)amino]-6-methyl-2-pyrimidinyl]-1-Ethyl-N4,N5-dimethyl-1H-imidazole-4,5-dicarboxamideLysine5-DehydroavenasterolSM(d18:1/17:0)Linoleoylcarnitine (Car(18:2))Goyasaponin_IIICurine4-Amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acidThymol blue1-[4-(Trifluoromethoxy)benzyl]piperazine1-Lignoceroyl-2-hydroxy-sn-glycero-3-phosphocholineOxopalmitoleylcarnitine (Car(16:2-O))Lys-AspFenoxaprop-P-ethylcis-4-DecenoylcarnitineGuanineProstaglandin I2 (PGI2)1-MethylnicotinamideN-Acetyl-S-geranylgeranyl-L-cysteine4-Chloropyridine-2,6-dicarbohydrazidePC(38:7)4',5,7-Trihydroxy 3,3',6,8-tetramethoxyflavonePC(18:1(9Z)/18:0)Cytidine 5'-monophosphate (CMP)2-Docosahexaenoyl-1-stearoyl-sn-glycero-3-phosphoethanolamineGlycerol_1-(9Z-octadecenoate)_2-tetradecanoate_3-phosphateMyriocin1-Butylimidazole7-Methylguanine2-[(1E)-2-(4-Methoxyphenyl)ethenyl]-4(3H)-quinazolinonePhenol, 2-[[[2-(4-bromo-2,5-dimethoxyphenyl)ethyl]amino]methyl]-3-Ureidoisobutyric acidPE(22:5(4Z,7Z,10Z,13Z,16Z)/20:4(5Z,8Z,11Z,14Z))Pirimiphos-methyl-N-desethylN-(3-Chlorophenyl)-N'-(2-pyridinyl)thioureaArtemisetinAspartylhydroxyproline.beta.-Glutamic acidDecenedioylcarnitine (Car(10:1-O2))Arachidonic sulfonic acidLysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z))NadololLeucyl-GlutamineTyr-PhePipecolic acidPhe-ValGlucose 6-phosphate2-Amino-3-methoxybenzoic acid3'-Keto-3'-deoxy-AMPPC(38:5)5-Acetoacetamido-2-benzimidazoloneProstaglandin F2.alpha. dimethylamineHeptanedioic acid, 1-(2-cyclopentylidenehydrazide)Alisol B acetateCarnitine1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-oneMESLPC(16:0)butoconazole3-acetyl-NADH(22E,24R)-Stigmasta-4,22-diene-3,6-dione3alpha-Acetomethoxy-11alpha-oxo-12-ursen-24-oic_acidGenistein6-(2-Pyridinyl)-1,3,5-triazine-2,4-diamine6-Methoxy-3-nitro-2-pyridinamineMuscimolLanceolatin B2-(3,4'-Dihydroxy-4,4,7,8a-tetramethyl-6'-oxospiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-3,8-dihydrofuro[2,3-e]isoindole]-7'-yl)-3-methylbutanoic acid2-Amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid(R)-AminocarnitinePC(16:1(9Z)/14:0)Isobutyrylcarnitine (Car(4:0))N6,N6,N6-TrimethyllysineN-cis-Octadec-9-enoyl-L-homoserine lactonePS(18:3(9Z,12Z,15Z)/20:3(8Z,11Z,14Z))Ethyl_beta-D-glucopyranoside1-MethyladenosineTOBRAMYCIN7-Hydroxy-2-acetylaminofluorene4-HydroxyisoleucineMaleic hydrazide1,2-Dilinolenoyl-sn-glycero-3-phospho-(1'-rac-glycerol)1-MethylhistamineMethyl 2-chloro-6-(trifluoromethyl)pyridine-3-carboxylate.alpha.-ChaconineLPG(18:1(9Z))Car(18:1)Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylate2-Aminonicotinic acidO-PhosphoethanolamineM551T257Pro-LeuAmidosulfuron4-(4-Hydroxy-2-quinazolinyl)benzenesulfonamideN-Arachidonoyl-L-alanineLPC(15:0)TicagrelorlysoPC(26:1(5Z))PC(37:4)Isorhamnetin_3-O-[a-L-rhamnopyranosyl-(1->3)-a-L-rhamnopyranosyl-(1->6)-b-D-glucopyranoside]TrigonellineDiclofensine6-Chloro-7-fluoroisatinGanoderic acid HFonsecinN-(2,6-Dimethylphenyl)-N'-phenylthioureaDocosahexaenoylglycinePC(18:1(11Z)/15:0)SalicinN-.alpha.-(tert-Butoxycarbonyl)-L-lysine4-Chloro-2,3-difluoroanilineIsoleucylvalineBakers_yeast_extract1-MethylguanosinePiericidin C1Dulxanthone_EPC(18:1(9Z)/P-16:0)1-Butyl-3-methyl-1H-imidazol-3-ium cation4-(4-Amino-3-nitrophenyl)-1(2H)-phthalazinonePI(18:1(11Z)/16:1(9Z))Fenfluramine3,5-Dimethoxy-N-4-pyridinylbenzamideMeclizineazosemide2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-Pro-ArgN-Isobutyl-3-methylbutanamide4-Piperidinamine, 1-(9H-purin-6-yl)-Tetraethylammonium cationCAPSAICINHexenedioylcarnitinePhenylalanineSph(d18:2)Glucoliquiritin apiosideErythromycylamine4-(Pentafluorosulfanyl)anilinePsoralidinSer-Arg1-Cyclobutyl-4-piperidinaminePentaethylene glycolpibutidinePersicachrome(E)-2-Cyano-1-(tert-pentyl)guanidineQuercetin-3-O-galactosideN-(9-Oxodecyl)acetamideTetradecenedioylcarnitine (Car(14:1-O2))(1-Oxo-2(1H)-phthalazinyl)acetic acid3,6-Dichloro-N-(pyridin-2-ylmethyl)pyridazine-4-carboxamide5-Methylisoxazol-3-amine2-MethylpropanamineCreatineM356T2542-Hydroxy-4,6-dimethylpyrimidineDebenzoylzucchini_factor_BPS(16:0/15:0)(4OH,8Z,t18:1)_sphingosineFenthion sulfoxideguanfacinePC(22:0/16:1(9Z))Palmitoleylcarnitine (Car(16:1))Cytosine6-Aminonicotinic acid2-Amino-4,6-dinitrotoluene2-AcetylthiazoleLaurocapram3-{2-[(E)-2-(Phenylamino)ethenyl]-4,5-dihydro-1,3-thiazol-3-ium-3-yl}propane-1-sulfonateN6-Methyladenosine1-BenzylpiperazineN2,N2-Dimethylguanosine12-Hydroxy-12-octadecanoylcarnitineN-Cyclohexylbenzenecarbothioamide(24E)-3-Oxodammara-1,12,24-trien-26-oic acidN1,N2-DiisobutylethanediamideN,N-Dimethylarginine (ADMA)NAE(18:1)LoracarbefPS(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))PehanormArachidyl_carnitinePE(P-36:4)3-HydroxysintaxanthinPimonidazoleStatineHis-AlaS1P(d18:1)3-Bromoquinolin-4-amineVal-ValPC(35:4)LPC(18:0/0:0)7.alpha.-Thiospironolactone2-Chloro-4-(dimethylamino)-5-fluoropyrimidineHomocarnosinePS(20:0/15:0)[4-Amino-2-(ethylamino)-1,3-thiazol-5-yl](4-chlorophenyl)methanoneEthephonGlycohyodeoxycholic acidIsoleucineThiomorpholine 3-carboxylateLysoPC(18:3(6Z,9Z,12Z))Mantabegron5-[[17-(5,6-dihydroxy-6-methylheptan-2-yl)-3,12-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-2-yl]oxy]-3-hydroxy-3-methyl-5-oxopentanoic acid4-Chloro-N-(4-methyl-1,3-thiazol-2-yl)benzenesulfonamideLPC(O-18:1)(5E)-2-Heptyl-3,4,7-trihydroxy-2,3,4,7,8,9-hexahydrooxecin-10-oneTrehalose_6-phosphateAmobarbital15-formyl-16-hydroxy-1,2,14,17,17-pentamethyl-8-(prop-1-en-2-yl)pentacyclo[11.7.0.0,.0,.0,]icosane-5-carboxylic acidArg-ThrM502T118Cytidine 5'-diphosphocholine (CDP-choline)PC(35:5)1,2-DimethylimidazoleMOPS1-Isobutyl-1H-pyrazol-5-ylamine1-Methyl-4-piperidinecarboxylic acid5-(2-Fluorophenyl)-2-furaldehydeDimethylethanolamineThiamine pyrophosphate (TPP)L-Menthone_1,2-glycerol_ketal2-(3-Bromophenyl)-1H-benzimidazole1,3-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ureacis-5-TetradecenoylcarnitineMethyl 5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylateN-(4-Methylphenyl)-1-piperidinesulfonamide3-Dodecyloxypropylamine2-(Naphthalen-1-yl)-1H-1,3-benzodiazoleStearamideN-[2-(3,4-Dimethoxyphenyl)ethyl]-2-thiophenecarboxamidePalmitoylcarnitine (Car(16:0))N-(4-Methyl-1,3-thiazol-2-yl)-N-(1-naphthyl)amine2-{2-[(4-Chlorophenyl)acetyl]hydrazino}-N-isopropyl-2-oxoacetamide1-alpha-Acevaltrate4,6'-AnhydrooxysporidinonePropionylcarnitine (Car(3:0))N-(2-Naphthyl)-4-nitrobenzamide2,2,6,6-Tetramethyl-4-piperidinyl 2-methylacrylateDeoxyadenosineOctanoylcarnitine (Car(8:0))PC(35:3)PA(20:5(5Z,8Z,11Z,14Z,17Z)/18:1(9Z))Erythraddison II2-Hydroxylauroylcarnitine4-Isothiocyanatopiazthiole3-Deazaneplanocin A3(2H)-Pyridazinone, 4-chloro-5-(4-morpholinyl)-Koeniginequinone_AGlycerophosphocholineAzetidine-2-carboxylic acidApo-12'-violaxanthalFlavin mononucleotide (FMN)Biphenyl-4-yl-p-tolylmethanoneTripropylamine(3-Ethyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)acetic acidChlorophyll_bN2-Benzyl-1,3,5-triazine-2,4-diamine2,3-Diphenyl-1H-indole-7-carboxylic acidPS(20:4(5Z,8Z,11Z,14Z)/15:0)4-Amino-N-(2,4-difluorophenyl)benzenesulfonamide1-Dodecyl-2-pyrrolidinoneIsovaleramide3-Pyridylacetic acidN-Methylglutamic acidAcadesine (Drug)2-MethylguanosinePipecolamideN-Acetylhistidinegamma-GlutamylglutamineTryptophanCordycepinFructose 6-phosphateCholineBoldenone sulfateLPS(22:6)FluorometholoneDocosahexaenoylserotonin(Arginyl)adenylate2,3,4-Pentanetrione, 3-[(4-nitrophenyl)hydrazone]Methanone, 1,1'-[2-(phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]-PE(20:4(5Z,8Z,11Z,14Z)/0:0)Cryptomeridiol_11-rhamnoside4-(2-Methyl-2H-tetraazol-5-yl)anilineAdenosine monophosphate (AMP)PC(20:4(8Z,11Z,14Z,17Z)/20:1(11Z))Ala-Lyso-Tyrosine2-AminopurinePiscidic Acid3-{[4-(Trifluoromethyl)phenyl]amino}cyclohex-2-en-1-onePhosphorylcholine1H-Pyrrole-2,5-dione, 1-[6-[[(17.beta.)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-S-Adenosylhomocysteine8-Oxo-dGMPM532T131PE(20:4(5Z,8Z,11Z,14Z)/16:0)Pro-AspAflatoxin_B1exo-8,9-epoxide-GSHErgoloid_MesylateHexanoylcarnitine (Car(6:0))Protoporphyrin IXHeptadecanoyl carnitine1H-Indazole-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-PE(P-38:6)Carbamic acid, N-10-undecyn-1-yl-, 3'-(aminocarbonyl)[1,1'-biphenyl]-3-yl esterHeneicosanoic_acid_(21:0)3-Hydroxystigmast-5-en-7-oneGDP-mannoseHis-TyrNifurtimox4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium cation2-(2-Naphthyl)-1,3-benzoxazol-5-amineLeucineLysoPC(22:1(13Z))5-phospho-alpha-ribose-1-preQ02-Chloro-6-fluoroquinoline-3-carbonitrile3-(2-Amino-4-methyl-6-oxo-1,6-dihydro-5-pyrimidinyl)propanoic acidHis-Aspgamma-ChaconinePiperidineN-(3-((3-((3-Hydroxy-6-methylheptanoyl)oxy)-6-methylheptanoyl)oxy)-8-methylnonanoyl)serinePro-ProArg-AlaTuberonic acid2-Stearyl_citrateAtazanavirPerifosine1,8-dihydroxy-3-methylanthra-9,10-quinoneCyclohexyl(phenyl)[3-(piperidin-1-yl)propyl]silanol2-Chloro-3-(piperidin-1-yl)quinoxalineLPI(18:0)PC(20:1(11Z)/15:0)3-Hydroxy-cis-5-tetradecenoylcarnitineHexadecatetraenoylcarnitine (Car(16:4))LysoPC(20:2(11Z,14Z))7-(Ethylamino)-6-methyl-4-(trifluoromethyl)-2H-chromen-2-onePA(18:3(9Z,12Z,15Z)/16:1(9Z))NorbuprenorphineN,N-Dimethyl-L-valine8-[(2-Hydroxyethyl)amino]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dioneN-((7E,11Z)-6,13,14-Trihydroxy-3-(1H-indol-3-ylmethyl)-4,5,10,12-tetramethyl-1,17-dioxo-2,3,3a,6,6a,9,10,13,14,15,16,17-dodecahydro-1H-cyclotrideca[d]isoindol-15-yl)acetamideArachidonyl_carnitineRiboflavin2-Pyrimidinylacetic acidMeAIBPC(42:7)SM(d18:1/14:0)4-[(3,5-Dinitrobenzoyl)amino]benzoic acid4-Chloro-5,6,7,8-tetrahydroquinazolin-2-amine1H-Pyrazole, 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-(S,S)-(+)-Tetrandrine6-Azauracil3,3-Dimethylpyrrolidin-2-one(2R)-2-(2,5-Difluorophenyl)pyrrolidineLys-ValAminocyclopyrachlorParaoxonN-(Furan-2-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine1-[2,6-Dinitro-4-(trifluoromethyl)phenyl]hydrazine1-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acidHydroxyvarenicline, N-trifluoroacetyl-4-AminobutanamidePE(P-18:1(9Z)/20:5(5Z,8Z,11Z,14Z,17Z))Glucosylgalactosyl_hydroxylysineD-erythro-Sphingosine C-20r-Aminobutyryl-lysine5-Nitro-N-(3-pyridinylmethyl)-2-furamidePC(16:1(9Z)/0:0)[U]Ricinoleic acid methyl esterLauric diethanolamideGlycine1,4,7,10,13,16-HexaoxacyclooctadecanePC(20:3(5Z,8Z,11Z)/14:0)AnhydrocinnzeylanolGlu-ArgN,N,1,2-Tetramethylcyclopropane-1-carboxamideCystathionine1-Oxa-4,7,10-triazacyclododecanePC(32:1)N-Phenyl-N'-(3-pyridinylcarbonyl)thioureaHexahydro-6,7-dihydroxy-5-(hydroxymethyl)-3-(2-hydroxyphenyl)-2H-pyrano[2,3-d]oxazol-2-oneAdenylsuccinic acidGinkgolide CMelaminePropanoic acid, 2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methyl-M258T481-Hexadecylpyridinium cationButyrylcarnitine (Car(4:0))MLS001077323-01!51333-22-3(-)-PodophyllotoxinPC(P-34:0)1-O-Hexadecyl-2-O-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glyceryl-3-phosphorylcholine3-DeacetylsalanninUndecenedioylcarnitine (Car(11:1-O2))(3S)-1-Azabicyclo[2.2.2]octan-3-amineCyanazinePC(16:0/P-16:0)3-Hydroxyhexadecanoylcarnitine(3-Methylbutyl)(6-methylheptan-2-yl)amineTelon Yellow 4R2-(4-Pyridinyl)malonaldehydeGuanosine7-Keto-8-aminopelargonic acid1-acyl-PAFPC(15:0/20:1(11Z))1-(3-Chlorophenyl)-3-[1-(3,4-dichlorobenzyl)-1H-pyrazol-3-yl]ureaPC(40:9)7-Amino-4-methyl-2H-1-benzopyran-2-one arachidonoyl amideLysoPC(18:1(11Z))Isoleucyl-PhenylalanineMesotrione3-Amino-2,5-dichlorobenzoic acidLPC(19:0)1-Tetrahydro-3-furanyl-4-piperidinaminePolyporusterone A6,7-Diethoxy-4-methylcoumarin17-HydroxycalactinSpisulosineHymexazolePolysorbate_60Oxododecanoylcarnitine (Car(12:1-O))4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)butanoic acidPalmitoyl sphingomyelinbeta1-ChaconineEpiafzelechin_3-O-gallatePC(10:0/10:0)trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane1-MethylguanineCer(d18:0/14:0)UridinePutative Phenylalanine conjugated chenodeoxycholic acid3-[4-(4-Hydroxy-2-quinazolinyl)benzyl]-2,4-imidazolidinedione5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid2-Chloro-3-fluoro-4-formylpyridine2-HydroxymyristoylcarnitineProlinePC(18:2(9Z,12Z)/15:0)Asticolorin_BPC(40:7)Decanoylcarnitine (Car(10:0))BeclomethasoneN-[2-(5,6-Dimethyl-1H-benzimidazol-2-yl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamideGlutarylcarnitine1-Palmitoyl-2-thiopalmitoyl phosphatidylcholineThiamine3-HydroxylinoleoylcarnitineProbenecid1H-Indazole-3-carboxamide, 1-(5-fluoropentyl)-N-8-quinolinyl-Ile-Ser5-Bromo-2-chloroisonicotinic acid3-Hydroxyicos-13-enoylcarnitineNeoeriocitrinN-MethylvalineSulfamerazine2-(4-Pyridinyl)ethanolCyclic adenosine diphosphate-ribose (cADPR)Argininosuccinic acid8-(2,3-dihydroxy-3-methylbutyl)-7-methoxychromen-2-one.beta.-Homoproline3-Oxo-2-[3-(trifluoromethyl)phenyl]-2,3-dihydro-1H-isoindole-4-carboxylic acid3-(Allylsulfanyl)-6-methyl-1,2,4-triazin-5-olN,N-Dimethyl-N-(2-phenoxyethyl)-1-dodecanaminium cationEthyl 2-amino-5-ethyl-3-thiophenecarboxylate(2R)-3-HydroxyisovaleroylcarnitineEtrimfosDaltogenEthyl 5-(2-chloroacetyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate1,3,4,6,7,8-Hexahydro-1-methyl-2H-pyrimido[1,2-a]pyrimidine2-(3,4,5-Trimethoxyphenyl)-1H-benzimidazoleSpermidinebetulin8-IsobutanoylneosolaniolIcosa-5,8,10,12,14-pentaenoylcarnitine[1-hydroxy-1-(4-methoxyphenyl)propan-2-yl] 4-methoxybenzoate3'-O-MethyladenosinePhenol, 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-Pentadecanoylcarnitine (Car(15:0))Aspulvinone_HPE(18:3(9Z,12Z,15Z)/20:3(5Z,8Z,11Z))AlnustoneUrocanic acid5-Norbornene-2,3-dicarboximide, N-(2-ethylhexyl)-1-Behenoyl-2-hydroxy-sn-glycero-3-phosphocholinePC(20:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))TolmetinStigmastane-3,6-dioneArg-Gly5-Methylcytidine4-Chloro-6-(1H-imidazol-1-yl)pyrimidineTetraethylene glycolArg-GlnLPS(18:1)DEHPN-Oleoyl-D-erythro-sphingosylphosphorylcholine1-(4-Bromophenylsulfonyl)-4-butylpiperazineCreatinineHis-Glu1,3-DimethylpyrazoleAspartateGuanosine 5'-diphosphate (GDP)N-(1-Deoxy-b-D-fructopyranosyl)_(R)C(S)S-alliinM516T105Adenosine 2',3'-cyclic phosphate2-(2-{4-[2-(1,3-Benzoxazol-2-yl)ethenyl]phenyl}ethenyl)-1,3-benzoxazoleLPS(18:0)N-Desmethyldiltiazem4-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]morpholineValineTiglylcarnitine (Car(5:1))Benz[a]anthracen-1-ol, 8-methoxy-3-methyl-Hexaethylene glycolAstaxanthin4-MethoxybutyrylfentanylDecamethylcyclopentasiloxaneTris(2,4-di-tert-butylphenyl)phosphate5-MethyldeoxycytidinesclareolArgininic_acidBetaineL-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-Tyrosine phenylthiohydantoin1,6-Bis(acetyloxy)-4,4,9,11b-tetramethyl-8-oxotetradecahydro-9,11a-methanocyclohepta[a]naphthalen-5-yl benzoate(4-Oxo-1,2,3-benzotriazin-3(4H)-yl)acetic acid1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine5-Pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-Cytidine5-[(2-Phenylethyl)amino]-1,3,4-thiadiazole-2(3H)-thioneEthyl nitroacetateSuccinamide3,4,5-trimethoxycinnamic acidPS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))5-Methyl DL-glutamateHeptadecenoylcarnitine (Car(17:1))Palmitoyleicosapentaenoyl phosphatidylcholineH-Val-Ala-OH3-[(3-Nitroanilino)carbonyl]-2-naphthyl dihydrogen phosphate1-Hexadecylamine1-Methylhistidine6-(1-Naphthyl)-5-nitro-2-piperidinonePC(18:1(9Z)/18:1(9Z))Dodecenoylcarnitine (Car(12:1))SphinganineLPC(17:0/0:0)3,8-Dihydroxy-1-methylanthraquinone-2-carboxylic_acidGlycerophosphoethanolamineTriphenylphosphine oxide4-Bromophenyl 1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl ether5-(2H-Chromen-3-ylmethylene)-2,4,6(1H,3H,5H)-pyrimidinetrione3-Methylcatecholn-OctadecylamineFluocinolone acetonideconhydrinoneOxybutyninPentylenetetrazolePhe-His6.beta.-Hydroxytriamcinolone acetonidePC(18:1(6Z)/18:1(6Z))(5Z)-5-(2,5-Dimethoxybenzylidene)-3-(furan-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-onePC(22:5(7Z,10Z,13Z,16Z,19Z)/20:5(5Z,8Z,11Z,14Z,17Z))GallocatechinBistrisPC(14:1(9Z)/20:5(5Z,8Z,11Z,14Z,17Z))6a_MethylprednisoloneSM(d18:1/20:0)4'-Hydroxyflurbiprofen7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine, N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-PC(20:4(5Z,8Z,11Z,14Z)/14:0)2-(9,10-Dioxo-9,10-dihydro-1-anthracenyl)-1H-isoindole-1,3(2H)-dione.delta.-TocotrienolTetramethylthioureaTandutinib2-(1-Piperidyl)propan-2-olN2-Acetyllysinen-amylamineFlumetsulam4-Guanidinobutyric acidGly-Gly-GlyAdenosine 3'-monophosphateNicotinamide mononucleotide (NMN)Phe-TrpPC(P-18:1(9Z)/0:0)(3E)-4-Hydroxy-3-[hydroxy-[2-[(1E,3E)-6-hydroxyhepta-1,3-dienyl]-1,3,6-trimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]methylidene]-5-(hydroxymethyl)-1H-pyrrol-2-oneMethionine1-Palmitoyl-2-azelaoylphosphatidylcholineN-Pentyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amineGlabroneLauroylcarnitine5a-Hydroxy-4-(4-oxoquinazolin-3(4H)-yl)-2-(propan-2-yl)-4,5,5a,9c-tetrahydro-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dioneLysoPC(20:4(5Z,8Z,11Z,14Z))PC(44:10)[1,2,4]Triazolo[3,4-b][1,3]benzothiazole-3(2H)-thione3,4-ThiophenedicarbonitrileIsovalerylcarnitine (Car(5:0))4,5-Di-O-caffeoylquinic acidPS(16:0/16:0)4,4,6-Trimethyl-1-(4-methylphenyl)-1,4-dihydro-2-pyrimidinethiolGossypetin_8-glucuronide_3-glucoside3-Methoxytyramine6-(Chloromethyl)-N2-(2-naphthyl)-1,3,5-triazine-2,4-diamineDemoxepamSpironolactoneNonanoylcarnitine (Car(9:0))DesaminosulfamethazineGLYCEROL 2-PHOSPHATEM268T1595-Aminopentanal7-Bromo-4H,5H-pyrrolo[1,2-a]quinoxalin-4-one2-Chloro-4-(4,5-dihydro-1H-imidazol-2-yl)pyridineN-3-Oxohexadec-11Z-enoyl-L-homoserine lactoneGlutamine-glutamateIsoleucyl-AlanineHeptanoylcarnitine (Car(7:0))Sanguinarine3-methylcytidineGuanosine 5'-monophosphate (GMP)Eicoseneoylcarnitine (Car(20:1))3-(5-Chloro-1,3-benzothiazol-2-yl)propanoic acid1-O-Hexadecyl-2-O-(2E-butenoyl)-sn-glyceryl-3-phosphocholineFlurandrenolideN-Acetylmannosamine4-(Piperazin-1-yl)benzene-1-sulfonamidePipericine4-Hydroxybenzoyl-adenylatePhenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-NorleucineTrimethylaminoacetone3-(Difluoromethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amineMesoporphyrin IX1-(Cyclohexylmethyl)prolineKanzonol_FArachidonoylcarnitine (Car(20:4))Lys-TrpPentadecylamineAviprin1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholineLPE(22:4)Tyrosine3-HydroxyarachidonoylcarnitineIle-LeuCinidon-ethylAcetylcarnitine (Car(2:0))ResmethrinLauramine oxideDye X-12948-139DAustalide_KLys-AlaEthyl 2-amino-4-phenylthiophene-3-carboxylate5-(4-Methylpiperazin-1-yl)-5-oxopentanoic acidHypoxanthineLurasidoneTriadimefon1,5-Diphenoxy-9,10-dihydroanthracene-9,10-dioneglutathione sulfinate3,7,8-Trihydroxy-3-methyl-1,4-dihydropyrano[4,3-b]chromen-10-one4,6-Dichloro-2-cyclopropyl-5-methylpyrimidineLysoPC(0:0/18:0)PE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/20:3(8Z,11Z,14Z))Uridine 5'-monophosphate (UMP)Putrescine7-[(6-hydroxy-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl)methoxy]chromen-2-one3-Pyridinylboronic acid3-Hydroxyoleylcarnitine7H-[1,2,4]Triazolo[4,3-b][1,2,4]triazole-3,7-diamine26,27-Dinorcholest-5-en-24-yne-3,20-diol, (3.beta.)-5,6-Difluoro-1H-indole-3-acetic acid7-Hydroxycoumarin-3-carboxylic acidPC(20:3(5Z,8Z,11Z)/18:0)17-Phenyltrinor-13,14-dihydroprostaglandin A2SongorinePC(18:4(6Z,9Z,12Z,15Z)/20:3(8Z,11Z,14Z))LPI(20:4)PE(20:5(5Z,8Z,11Z,14Z,17Z)/20:2(11Z,14Z))3-Bromo-2-tert-butylimidazo[1,2-a]pyrimidineAlloimperatorinInosineirigenin4-Chloro-5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidineMethyl_3,4,6-tri-O-galloyl-beta-D-glucopyranoside[2-Amino-1-(2-chlorophenyl)ethyl]dimethylamineMethylimidazoleacetic acid2-(2,6-Dimethylmorpholin-4-yl)ethanol6-Hydroxyeurycomalactone2-Oxo-S-phenyl-2-(piperidin-1-yl)ethane-1-sulfonamidoSpeciosideOuabainLeu-Ile5,6,7,8-Tetrahydrothieno[2,3-b]quinolin-4-amineLPC(18:2/0:0)Serine-Cholic AcidLansioside_CN-(4-Phenoxyphenyl)-2-pyrazinecarboxamidePC(P-16:0/0:0)PirimicarbAla-GluAnserine(3b,4b,11b,14b)-11-Ethoxy-3,4-epoxy-14-hydroxy-12-cyathen-15-al_14-xylosideLys-Gln3-MethylhistidineSM(d16:1/24:1(15Z))5-Phosphonooxy-L-lysineGentian violet cationMetharbitalPC(42:10)Myristoylcarnitine2-Aminopyridine(2S,4S)-4-Cyclohexylpyrrolidine-2-carboxylic acid2-(Dipentylamino)-2-(hydroxymethyl)-1,3-propanediol4-(4-tert-Butylphenyl)-1,3-thiazol-2-ylamineCDP-EthanolamineD-erythro-D-galacto-octitolTheaflavinMethyl 4-(trifluoromethyl)benzoylacetate1-(2,4,5-Trimethoxyphenyl)-1,2-propanedionePC(14:0/14:0)Testosterone decanoateN-n-Butylpropionamide3beta-Ergosta-5,23-dien-3-ol4-Methyl-2-phenyl-1,3-thiazole-5-carboxylic acid1-Hydroxy Vitamin D2Arg-Gly-Asp1,2-Dilinoleoyl-sn-glycero-3-phosphoethanolamineHalofantrine2-(S-Glutathionyl)acetyl_chloridePE(18:0/18:2)DodemorphIle-Trp2-(2-Methoxyethoxy)ethanamine3',5'-Cyclic Inosine monophosphate4-Amino-9-methoxypsoralenGlucose 1-phosphateUridine 5'-diphosphate (UDP)1-Myristoyl-sn-glycero-3-phosphocholine (LPC(14:0/0:0))Cefpimizole_sodiumNodakenitinalpha-Santalyl_phenylacetate2-Amino-3-bromonaphthoquinoneCincassiol_BPro-ValMethyl 6-chloro-4-oxo-4H-chromene-2-carboxylateStreptomycin AADP-riboseIsopropalin2-Pentenoic acid, 5-(4-chlorophenyl)-3-phenyl-, (2Z)-AcetylcholineOctenoyl-carnitineBenoxacorValerylcarnitinePC(22:2)1-(2,5-Dimethylphenoxy)-3-(4-morpholinyl)-2-propanolSph(t18:0)N-Arachidonoyldopamine2-[(2-Methylpropyl)amino]acetic acid2-Amino-3-[5-tert-butyl-3-(phosphonomethoxy)isoxazol-4-yl]propionic acidCucurbitacin_B3-MethylglutarylcarnitinePI(16:0/16:1(9Z))Furmecyclox3-Methyl-1H-pyrazole-4-carbaldehydeDexamethasone acetatePS(20:3(8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-PC(14:0/16:0)Docos-13-enoylcarnitineErucamideProlyl-HistidineHistamineFurcelleranTriciribine1-[(3-Fluorophenyl)sulfonyl]piperazine5'-Deoxyadenosine3-hydroxyoctanoyl carnitineGlycerophospho-N-palmitoylethanolaminePC(42:9)GalactosylglycerolMitragynineNormetanephrinePyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-5-methyl-6-(1-methylethyl)-7-oxo-Arnamiol4-Aminobutyric acid (GABA)1-Phenyl-3-(trifluoromethyl)-1H-pyrazol-5-ol1,3-DimethyluracilAspochalasin DPyrrolidineDocosatetraenoylcarnitine4-(4-Chlorophenyl)-6-(difluoromethyl)-2-(ethylsulfonyl)pyrimidineL-N5-(1-Imino-3-pentenyl)ornithine2-(4-Methyl-5-thiazolyl)ethyl_isobutyrateL-?Leucyl-?L-?alanine4-[(6-Aminopyrimidin-4-yl)amino]benzenesulfonamideEtonogestrelPhe-Ala(3E)-4-Hydroxy-3-[hydroxy-[2-[(1E,3E)-6-hydroxyhepta-1,3-dienyl]-1,3,6-trimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]methylidene]-5-(hydroxymethyl)-1-methylpyrrol-2-onefalseMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics IntegrationEtomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tissue was performed using data-independent acquisition (DIA) liquid chromatography–tandem mass spectrometry and quadrupole time-of-flight mass spectrometry, respectively; integrated multi-omics candidates were verified by parallel reaction monitoring (PRM). Both low- and high-dose etomidate significantly increased CPP scores, indicating robust rewarding properties. Neuronal and hepatic lesions increased with dose, with the prefrontal cortex and ventral tegmental area showing the greatest brain vulnerability. Integrated proteomic and metabolomic analyses indicated shared biotransformation- and stress-response features across brain and liver, with brain changes mainly involving xenobiotic metabolism, oxidative stress-related detoxification, and synaptic signaling and cAMP–RAS signaling, and liver changes mainly involving cytochrome P450-mediated biotransformation, lipid and fatty-acid metabolism, and lethal-stage catabolic remodeling. Metabolomics showed dose-stratified pathway disruption: low-dose exposure affected aminoacyl-tRNA and amino acid biosynthesis, high-dose exposure perturbed amino acid and carbon metabolism, and lethal doses altered purine metabolism and glutamatergic pathways. The main innovation of this study lies in establishing a dose-stratified mouse model that integrates CPP behavior, brain and liver pathological injury, and cross-organ proteomic–metabolomic profiling, thereby extending existing evidence of etomidate-related reward and toxicity and delineating a combined molecular profile of etomidate-induced reward-related behavior and organ toxicity.2026-09-022026-09-02MTBLS15525