MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/m_MTBLS15538_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/m_MTBLS15538_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/a_MTBLS15538_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/s_MTBLS15538.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/a_MTBLS15538_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con5-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con4-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con3-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con5-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH5-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con4-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH6-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con6-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH6-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con6-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH5-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH4-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC1-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH3-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH4-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH2-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH1-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH2-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH1-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC2-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC4-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC1-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/CrH3-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC5-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC2-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC3-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC3-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC7-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con2-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC4-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC6-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con3-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC5-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con2-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC6-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/QC7-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con1-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538/FILES/RAW_FILES/Con1-neg.rawprimary200OKftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15538<p>Metabolites were annotated by matching accurate mass, retention time, and MS/MS fragmentation information against mzCloud, mzVault, and MassList databases. Positive and negative ion mode datasets were processed separately.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>Chromatographic separation was performed using a Vanquish UHPLC system equipped with a Hypersil GOLD C18 column (100 × 2.1 mm, 1.9 μm; Thermo Fisher Scientific). The column temperature was maintained at 40°C, and the flow rate was 0.2 mL/min. For positive ion mode, mobile phase A consisted of 0.1% formic acid in water, and mobile phase B was methanol. For negative ion mode, mobile phase A consisted of 5 mmol/L ammonium acetate in water, adjusted to pH 9.0, and mobile phase B was methanol. The gradient elution program was as follows: 0–1.5 min, 2% B; 1.5–4.5 min, 2%–100% B; 4.5–10.0 min, 100% B; 10.0–10.1 min, 100%–2% B; and 10.1–12.0 min, 2% B.</p>Maternal plasma metabolomic profiling of periparturient dairy cows supplemented with high-dose chromium propionate before calving.yuzhen SuiNorth West Agriculture and Forestry Universityplasmamass spectrometry assay<p>Chromatographic separation was performed using a Vanquish UHPLC system equipped with a Hypersil GOLD C18 column (100 × 2.1 mm, 1.9 μm; Thermo Fisher Scientific). The column temperature was maintained at 40°C and the flow rate was 0.2 mL/min. For positive ion mode, mobile phase A consisted of 0.1% formic acid in water and mobile phase B was methanol. For negative ion mode, mobile phase A consisted of 5 mmol/L ammonium acetate in water, adjusted to pH 9.0, and mobile phase B was methanol. The gradient elution program was as follows: 0–1.5 min, 2% B; 1.5–4.5 min, 2%–100% B; 4.5–10.0 min, 100% B; 10.0–10.1 min, 100%–2% B; and 10.1–12.0 min, 2% B.</p>Bos taurushttps://www.ebi.ac.uk/metabolights/MTBLS15538yuzhen Sui. North West Agriculture and Forestry University. sui1632020@163.com.<p>Raw LC-MS/MS data were processed using Compound Discoverer software version 3.3. Data processing included retention time correction, peak detection, peak alignment, peak area integration, and relative quantification. Peak intensities were normalized using the total peak area method. Metabolic features with a coefficient of variation greater than 30% in quality control samples were excluded from downstream analysis.</p>Treatmentsui1632020@163.com<p>Maternal plasma samples were obtained from Holstein dairy cows enrolled in a prepartum chromium propionate supplementation experiment. Cows in the control group received a basal total mixed ration without supplemental chromium propionate, whereas cows in the high-dose chromium propionate group received the same ration supplemented with 20 g chromium propionate per cow per day, providing 8 mg Cr(III) per cow per day, from 21 days before expected calving until parturition. On the day of calving, blood samples were collected from the coccygeal vein into 10 mL lithium heparin vacuum tubes. Plasma was separated by centrifugation at 2,000 × g for 10 min at 4°C, aliquoted into sterile tubes, and stored at −80°C until untargeted metabolomic analysis.</p>MetabolomicsOrbitrap Exploris 120 mass spectrometer, Thermo Fisher ScientificMetabolomicsuntargeted analysisVanquish UHPLC system, Thermo Fisher Scientificperiparturient periodBos taurusplasmaLC_MS_MSpooled sampleOrbitrap Exploris 120 mass spectrometer, Thermo Fisher ScientificMetabolomicsuntargeted analysisVanquish UHPLC system, Thermo Fisher Scientificperiparturient periodBos taurusplasmaLC_MS_MSpooled sample<p>Mass spectrometric detection was performed using an Orbitrap Exploris 120 high-resolution mass spectrometer equipped with an electrospray ionization source. Samples were analyzed separately in positive and negative ion modes. The spray voltage was set to 3.5 kV, and full-scan MS data were acquired over an m/z range of 100–1,500. MS/MS spectra were acquired in data-dependent acquisition mode for metabolite structural annotation.</p>2-{1-[2-(4-benzhydrylpiperazino)-2-oxoethyl]cyclopentyl}acetic acid2-morpholino-1-phenyl-1-ethanolCorticosteroneProstaglandin G2DL-Panthenol2-[(3S)-1-(2-Methylbenzyl)-3-pyrrolidinyl]-1,3-benzoxazole8-Aminooctanoic acidMethyl nicotinatePC O-32:1PC O-32:31-(3,4-dimethoxyphenyl)ethan-1-one oximePC O-32:2L-HistidinePC O-32:4LPC 16:0-SN1PC O-32:72-Arachidonoyl glycerolPC O-32:6SM 8:1;2O/28:71-[(3,5-dimethylisoxazol-4-yl)sulfonyl]piperidineL-Tyrosinemethylester4-methylphenyl 1-ethyl-3-methyl-1H-pyrazole-5-carbothioateN-[1-(4-methoxy-2-oxo-2H-pyran-6-yl)-2-methylbutyl]acetamideMethyl indole-3-acetate6-Methoxy-2-naphthoic acid6-fluoro-3,4-dihydro-2H-pyrano[2,3-b]quinolin-5-amine3-(5,7-dimethoxy-4-oxo-4H-chromen-2-yl)propanoic acidHexanoylcarnitineHPKFLKDl-Indole-3-lactic acidL-lysineBis(3,5,5-trimethylhexyl) phthalateProline-hydroxyprolineEstradiolPC 15:0_16:2SM 8:1;2O/26:1LPC 24:1-SN1Pyridoxamine 5-phosphate3-(propan-2-yl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dione2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acidNor-9-carboxy-δ9-THCSM 8:1;2O/26:2Methyltestosterone6-MethylquinolinePC 42:5FMKOxohongdenafilD-(+)-MaltosePC 42:95-HydroxylysineFexofenadinePC 42:8LPC 30:36,8-dihydroxy-3-(10-hydroxyundecyl)-3,4-dihydro-1H-2-benzopyran-1-oneOleamideSM 8:1;2O/15:1N-Acetylneuraminic acidHRHPantothenic acid10-Undecenoic acidSL 12:2;O/16:2;OVindoline3-hydroxy-2-octylpentanedioic acid5-fluoro AB-PINACA N-(4-hydroxypentyl) metabolite7-KetocholesterolL-OrnithineWPH(±)15-HETEPC 14:0_15:1N-FormylkynureninePC 14:0_15:0PC O-30:3PC O-30:4LPE 22:64-[1-(dimethylamino)ethylidene]-2-phenyl-1,3-oxazol-5(4H)-oneCAR 18:2CAR 18:1CAR 18:0PC 34:4_36:10(2S)-2-(2-hydroxypropan-2-yl)-2H,3H,7H-furo[3,2-g]chromen-7-onePC O-30:14-oxododecanedioic acidPE 18:2_18:24-Methoxybenzaldehyde16,16-Dimethyl prostaglandin A21-Phenyl-3-methyl-5-pyrazolone4-Hydroxyquinoline(12Z)-9,10,11-trihydroxyoctadec-12-enoic acid5-Henicosyl-1,3-benzenediolAndrostenedione16,16-Dimethyl prostaglandin A13-(2-Naphthyl)-D-AlanineFPKIndolePC 17:1_18:5LPC 24:0-SN1DL-ArginineFIBF-d710-Nitrolinoleate4-(2,3-dihydro-1,4-benzodioxin-6-yl)butanoic acidL-Carnitineo-CresolSM 8:1;2O/28:0PC 40:8PC 40:5PC 40:6PE O-14:1_20:4DL-Norvaline1,3,5-Trimethylpyrazole2-Hydroxycinnamic acid4-morpholinobenzoic acidNoroxycodone-d32-(14,15-Epoxyeicosatrienoyl) glycerolFRHHydrocortisone acetateMelatonin4-Hydroxyretinoic AcidDaidzinL-Phenylalanine5-MethylcytosinePropionyl-L-carnitine2,5-bis(4-hydroxy-3-methoxyphenyl)-3,4-dimethyloxolan-3-olOleanolic acidPC O-36:5PC O-36:4PC O-36:9EcgoninePC(16:0/16:0)L-(-)-MethioninePC O-36:1PC 16:0_17:1Tetrahydrocortisonegamma-Glutamylmethionine12-oxo Phytodienoic AcidCAR 16:1ThreonineSM 36:1;2OLPC O-21:13-(2-naphthyl)-5-(trifluoromethyl)-1H-pyrazole1-(2'-fluoro[1,1'-biphenyl]-4-yl)propan-1-oneDL-TryptophanLPC 22:5-SN1cis-7-Hexadecenoic Acid6-benzyl-4-oxo-1,4-dihydropyridine-3-carboxamideDGDG O-8:0_2:0PC O-14:04-Methoxycinnamic AcidAcetanilideethyl 3-oxo-3-(1H-pyrazol-5-ylamino)propanoate1,4-dihydroxyheptadec-16-en-2-yl acetateN'-[(2,4-dihydroxyphenyl)methylene]-4-methylbenzenesulfonohydrazidePC 18:1_19:26-(3-hydroxybutan-2-yl)-5-(hydroxymethyl)-4-methoxy-2H-pyran-2-oneDocosanamide2-Thiocytidine4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-methyl-1,3-thiazoleSM 8:1;2O/19:0Prostaglandin K2Tauroursodeoxycholic acidPipecolic acidPerillartineIndole-3-acrylic acidPC O-34:7PC O-34:6PC O-34:9PC O-34:8LPC 42:12-SN2PC O-34:1Indole-3-carboxaldehydePC O-34:3PC O-34:411-Ketoetiocholanolone4-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylamino)-4-oxobutanoic acidAsp-Phe2-methyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-4-oneBisphenol APC 19:1_19:1Ingenol-3-angelateL-GlutamateCafestolPE 17:0_17:11H-indene-3-carboxamide2-(2-methyl-1H-indol-3-yl)acetonitrileQNK3,6-dibenzyl-1,2-dihydro-1,2,4,5-tetraazineLPC 22:6-SN2LPC 22:6-SN1L-AdrenalineSM 32:2;2OPC O-12:03-[4-methyl-1-(2-methylpropanoyl)-3-oxocyclohexyl]butanoic acid(2E,4E)-N-[2-(4-hydroxyphenyl)ethyl]dodeca-2,4-dienamideProstaglandin J2CholecalciferolThymine16α-Hydroxydehydroepiandrosterone15-Deoxy-Δ12,14-prostaglandin A11-Methyluric acidStercobilinDiethyl maleateOleoyl-L-alpha-lysophosphatidic acid1-Methyladenosine4-Hydroxyisoleucine2-[3-methyl-2-(methylimino)-4-oxo-1,3-thiazolan-5-yl]acetic acidTaurodeoxycholic Acid (sodium salt)Coenzyme Q21-(4-methyl-2-morpholino-1,3-thiazol-5-yl)ethan-1-oneGuanidineacetic acid3-Hydroxy-3-methylbutanoic acidSPB 18:1;2OPC 20:5_22:6OxolamineLSD-d35,8-dihydroxy-10-methyl-5,8,9,10-tetrahydro-2H-oxecin-2-one5-Hydroxyindole-3-acetic acidCAR 12:1PC O-29:1PC O-29:0N6-Succinyl AdenosineSM 8:1;2O/31:07-MethylguanosineR-1 Methanandamide phosphate6β-Oxycodol N-oxidePE O-14:1_18:1Stearoyl Ethanolamide2,3-dihydroxypropyl 12-methyltridecanoatePC 38:0PC 38:6Dibenzoyl ThiaminePC 38:4PC 38:5AlternariolPC O-18:0LPC 20:2-SN1PC O-18:1PC O-18:2cis,cis-Muconic acidPC O-18:3Octanedioic acidLPC 38:6Cer 8:0;3O/15:1;(2OH)5-hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-oneLPC O-15:02-OxindoleN1-(1-benzyl-4-piperidyl)-4-chlorobenzene-1-sulfonamideN-TetradecanamideSM 8:0;2O/25:0LPC 22:3-SN1N-MethyldioctylaminePyrogallol8,15-DiheteTestosteroneLevothyroxineDibutyl sebacateN1-[4-hydroxy-6-(methoxymethyl)pyrimidin-2-yl]acetamide4-Aminobutyric acidIsohomovanillic acidCuminaldehyde(2,6-dimethylmorpholino)(1-methyl-5-nitro-1H-pyrazol-4-yl)methanoneL-KynureninePC 18:4_18:4Creatine4-(4-nitrophenylazo)anilinePC O-38:44-oxo-5-phenylpentanoic acidPC O-38:7PC O-38:6PC O-38:9PC O-38:8Cytosine16-Heptadecyne-1,2,4-triolPC 19:2_18:5(S)-Leucic acidPC 19:2_18:3PC 19:2_18:4SM 30:1;2ON2,N2-DimethylguanosineCAR 10:1N-acetyl-L-ornithineethyl 3-[(4-chlorophenethyl)amino]-2-cyanoacrylate2-[(3S)-1-Benzyl-3-pyrrolidinyl]-1-methyl-1H-benzimidazolePC 36:2PC 34:3_36:10SM 9:1;2O/28:7α-Hydroxyhippuric acidSM 8:1;2O/20:0Nicotinuric Acid2-(4-methoxyphenyl)-3-(1H-pyrazol-4-yl)acrylonitrileLPC O-13:1PC O-16:0LPC 20:3-SN1PC O-16:13-(methylsulfonyl)-2H-chromen-2-oneLPC 23:0-SN1KKKErgosta-5,7,9(11),22-Tetraen-3-beta-Ol(11E,15Z)-9,10,13-trihydroxyoctadeca-11,15-dienoic acidLPC 22:4-SN1L-(+)-CitrullineD-PanthenolL-beta-Imidazolelactic acidVitamin ASodium cholateDelta-TridecalactoneStearamideSphingosine (d18:1)Asp-Phe methyl esterPC O-40:6N4-AcetylcytidinePC O-40:4PC O-40:9SM 8:1;2O/35:0Luteolin-3',7-DiglucosidePC O-40:7PC O-40:8SM 8:0;2O/18:0CE 18:2Quinoline-4-carboxylic acid7-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-2H-chromen-2-one25-hydroxycholecalciferolSkatoleSM 8:1;2O/22:05-[(10Z)-14-(3,5-dihydroxyphenyl)tetradec-10-en-1-yl]benzene-1,3-diol2-phenyl-2,4,6,7-tetrahydrothiino[4,3-c]pyrazol-3-olPC 18:0_18:1Choline GlycerophosphateSM 8:1;2O/22:2All-Trans-13,14-DihydroretinolLPC 34:33,4-dihydro-4-oxo-2H-1,3-benzoxazine-2-spiro-4'-(1'-ethylpiperidine)DiflorasoneDi(2-ethylhexyl) phthalateDecanoylcarnitineCholinebeta-Estradiol 17-AcetateL-Methionine sulfone2-methyl-6-{[(5-phenyl-2-thienyl)carbonyl]amino}benzoic acidSDMA(5E)-7-methylidene-10-oxo-4-(propan-2-yl)undec-5-enoic acidOctadecanamineL-Hydroxyproline3,4-MethylenedioxyethamphetaminePC 42:9_44:12PC 15:1_15:1L-IsoleucineBicyclo Prostaglandin E2PC 19:0_19:1SM 33:1;2OSM 8:1;2O/26:6PC 18:2_19:2PE O-13:1_20:4PalmitoylcarnitineIndole-3-pyruvic acidUndecanedioic acidGlycyl-L-leucineN1-[3,5-di(trifluoromethyl)phenyl]-3-(3-thienyl)acrylamide2-{(3S)-1-[4-(Trifluoromethyl)benzyl]-3-pyrrolidinyl}-1H-benzimidazoleSM 9:1;2O/24:6Diosgenin2,3-Dinor-11β-prostaglandin F2αPC O-42:10PC O-42:11SM 43:1;2OINKL-ArgininosuccinateBitertanol3-(3-morpholinopropyl)-2-(2-pyridinyl)-2,3-dihydro-4(1H)-quinazolinoneSM 8:1;2O/24:3SM 8:1;2O/24:25,7-dimethyl-4-oxo-4H-chromene-3-carbonitrileSM 8:1;2O/24:1LPC O-17:2SM 8:1;2O/24:0H-Gly-Pro-OHLPC O-17:0Furanyl fentanyl 3-furancarboxamide isomer-d5D-(+)-ProlineSM 8:0;2O/27:0DL-Glutamineindoline-2-carboxylic acidPhosphocholinepentane-1,2,3,4,5-pentol5-Methyl-dl-tryptophan5-(hydroxymethyl)-4-methoxy-2,5-dihydrofuran-2-oneEstroneSM 8:1;2O/13:1ethyl 3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboxylateSM 8:1;2O/13:0LPC 20:1-SN12-Methoxyestradiol (2-MeOE2)LPC 40:8LPC 40:75,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-oneLPC 42:10Leu-ProPC O-20:0L-(-)-alpha-Amino-epsilon-CaprolactamLimoninSM 9:1;2O/30:6SM 9:1;2O/30:7SM 9:1;2O/30:8QuinolineFeruloyl PutrescineSM 39:1;2OAll trans-Retinal2-Anisic acidBiotinD-RaffinoseLPC 20:5-SN13-Hydroxyanthranilic acidTributyl citrate2-phenyl-4H-furo[2,3-h]chromen-4-one9-HOTrEPC 16:1_16:2PC 14:0_14:0(+/-)11(12)-DiHETOleic acidPC O-33:2PC O-33:1PC O-33:3H-Trp-NH2Lysopc 20:4PC 17:2_17:24-MethylaminoantipyrineLysopc 20:0gamma-Nonanolactone11-OxoetiocholanolonePC O-40:11PI 38:4PC O-40:10PI 38:3LPC 18:1-SN1PC O-22:44-Pyridoxic acidPC O-22:5LPC 22:0-SN1Azaspiracid-1Octyl hydrogen phthalate5-[4-(phenylsulfonyl)phenyl]-1H-pyrazole2,4-dihydroxyheptadec-16-en-1-yl acetateLPC 42:9N-Acetyl-L-methionine13,14-dihydro-15-keto Prostaglandin A25'-S-Methyl-5'-thioadenosineDL-Lysine17alpha-HydroxyprogesteronePC 42:6_44:121,7-bis(4-hydroxyphenyl)-5-methoxyheptan-3-onePC 34:6_34:7SM 8:1;2O/29:0SM 9:1;2O/32:1GQHBiliverdinPC 41:52-(4,4-diphenyl-1-piperidinobuta-1,3-dienyl)phenyl acetateLPC 20:4-SN1Palmitoyl sphingomyelinPC O-42:9TKK1-Methylguanine2-hydroxy-3,6-diphenylcyclohexyl acetatePC O-42:8SM 8:1;2O/18:0ENHSPB 16:1;2OHydroxyprogesterone caproate7-(1-pyrrolidinyl)pyrimido[4,5-d]pyrimidin-4-amineProlineethyl 3-cyano-2-hydroxy-6-phenylisonicotinateU-44069AcipimoxLPC 20:0TLH1-Caffeoylquinic AcidPC O-31:2(2E)-6-hydroxy-2-methyl-6-(4-methylphenyl)hept-2-enoic acidPC O-31:1PC O-31:3PC O-31:6PC 16:2_16:21,2-dihydroxyheptadec-16-yn-4-yl acetateLPC 18:0-SN1CAR 17:0Indole-3-acetic acid3-methyl-5-oxo-5-(4-toluidino)pentanoic acidPC O-31:0L-Methionine Methyl EsterN1-(2-amino-2-oxoethyl)-2-(isopropylthio)acetamide(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(propan-2-yloxy)oxane-3,4,5-triolPC O-20:4PC O-20:3PI 36:2prop-2-ynyl 3-({[amino(imino)methyl]thio}methyl)benzoate hydrochloridePC O-20:5PI 36:1LPC 19:0-SN14-(1H-pyrazol-1-yl)-N,N-bis(2-pyridinylmethyl)benzenesulfonamidePC 17:1_17:2gamma-GlutamyltyrosineN-(5-acetamidopentyl)acetamide2-Arachidonyl Glycerol etherPhlorizinmethyl 3,4,5-trihydroxycyclohex-1-ene-1-carboxylateLPC 26:0-SN1PC 18:2_20:3Taurocholic acidFolinic acidErgosterol peroxideNorfentanyl8,8-dimethyl-2-phenyl-4H,8H-pyrano[2,3-h]chromen-4-oneAvocadyne 1-acetatePropionylcarnitine4-decyl-3-hydroxy-5-oxooxolane-2,3-dicarboxylic acidp-Mentha-1,3,8-triene3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6-diolPI 34:1Obscurolide A15-MethylcytidinePC O-37:5PC O-37:7benzaldehyde 1-(2,4-dinitrophenyl)hydrazoneβ-CortoloneDehydroepiandrosterone (DHEA)(±)13-HpODEN-Acetyl-aspartic acidCreatinineAKKAcetyl-L-carnitineCAR 15:1CAR 15:0PC 19:1_18:2LPC O-22:0Glycolithocholic acidValine2-Amino-1,3,4-octadecanetriolSM 32:1;2ON-[2-chloro-6-(trifluoromethoxy)phenyl]-2,2-dimethylpropanamideCapsaicinLinoleoyl ethanolamideLysoPE 18:2CortisolBilirubinSM 8:0;2O/30:0mesityl(piperidin-4-yl)methanone hydrochloridePE O-15:1_20:4PE O-15:1_20:5PC 15:0_15:0BetaineN-Methylhydantoin7-hydroxy-5-methoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-onePruninAL 8810 Methyl ester2-(methylsulfanyl)-4-quinazolinamine4-{3-[(3,4-dihydroxyphenyl)methyl]-2-methylbutyl}benzene-1,2-diolL-Leucyl-L-AlanineCytidinePC 18:1_18:1PC 18:1_18:2Isoquinolineoctadec-9-ynoic acidP-Aminohippuric AcidN-Benzylformamide7-methyl-3-nitroimidazo[1,2-a]pyridine1-Methylhistidine3-[3,5-bis(trifluoromethyl)phenyl]-N'-hydroxyprop-2-enimidamideCAR 24:0PC 16:0_18:5PC O-35:5DL-5-MethoxytryptophanPC O-35:2PC O-35:42-Thio-acetyl MAGE4-acetyl-4-(ethoxycarbonyl)heptanedioic acidDL-2-(acetylamino)-3-phenylpropanoic acid1-PalmitoylglycerolCAR 13:0Testosterone glucuronideMonooleinPC 20:3_20:3dUMPN-(6-methoxypyridin-3-yl)thiophene-2-carboxamideProgesteroneAPK3-(3,4-dihydroxyphenyl)propanoic acidProlylleucineGenistinPC 39:5DL-DipalmitoylphosphatidylcholineL-argininePC 39:45-(6-hydroxy-6-methyloctyl)-2,5-dihydrofuran-2-onePC O-17:15-HydroxytryptophanKynurenic acidLPC O-14:0PC O-17:03-Indoleacrylic acidMethyl 3-indolyacetate1-Aminocyclohexanecarboxylic acidMusconePalmitoylethanolamideTaurochenodeoxycholic Acid (sodium salt)MethionineN-lactoyl-phenylalanineLPC 19:2-SN1MAG (18:3)NKKN-[(dimethylamino)methylene]-4-methylbenzenesulfonamideDL-α-Aminocaprylic acid2'-DeoxycytidineStyreneRosmarinic acid2,6-Di-tert-butyl-1,4-benzoquinoneCAR 22:0LPC 17:1-SN111-Deoxy prostaglandin F1αSM 42:1;2O1-StearoylglycerolNAOrn 15:0/16:06-Deoxy-D-glucose3-Methylcrotonylglycine3-Methyladipic acidPC 17:0_18:4(1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-1,4,6-trien-3-onePC 17:0_18:2Glu-GlnPC 19:0_20:5SalsolinolSerotoninKojic acid2-(2-acetyl-3,5-dihydroxyphenyl)acetic acidFerulic acidLeucylprolineL-HomocitrullineLPC 15:0-SN15α-Dihydrotestosterone glucuronide(S)-Nicotine8-HydroxyquinolinePC 20:2_21:2α-AspartylphenylalanineCannabidivarinPC 37:2Dehydrocholic acidPC 37:5LPC 19:1-SN1PC 16:3_18:52-HydroxyphenylalanineLPC 18:4-SN1MethanandamidePC O-15:0(S)-AL 8810PC O-15:1Fisetin2-[(butylamino)(imino)methyl]-1-oxohydrazinium-1-olateLysoPC 10:0DL-Carnitine1-[2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-nitrophenyl]-1H-imidazoleHomoarginine3-Ureidopropionic acidSM 8:0;2O/22:0L-aspartic AcidDehydroepiandrosterone1,2-Dipalmitoylphosphatidylglycerol1-(4-Methoxyphenyl)-2-propanoneLPC 17:0-SN1Hypoxanthine1-(2-furyl)pentane-1,4-dioneSM 14:3;2O/22:6Palmitoyl ethanolamideD-glutamine4-[2-(2-oxo-1-imidazolidinyl)ethyl]-1lambda~6~,4-thiazinane-1,1-dioneHeptadecanoic AcidN-(cyclopropylmethyl)-N'-phenylurea2-{4-[(4-methylphenyl)sulfonyl]piperazino}-1-morpholino-1-ethanoneLLKPC O-39:8N6,N6,N6-Trimethyl-L-lysineMethyl palmitate2-Hydroxybutyric acid5-MethyluridinePC 18:5_18:511β-HydroxyandrosteronePalmitoleic Acid(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acidO1-(2,6-dichlorobenzyl)-4-methoxybenzene-1-carbohydroximamideD-Ala-D-AlaCortisoneGly-PhePC O-28:1PC O-28:3D-ProlineSM 8:1;2O/32:0SM 8:1;2O/32:3D-PhenylalanineMethylimidazoleacetic acidLPC 15:1-SN1LPC 18:3-SN1OuabainLNHTetranor-12(S)-HETEPanthenolisoleucinePregnenolone1,7-bis(4-hydroxyphenyl)heptan-3-oneSM 9:1;2O/34:1SM 8:1;2O/23:0PC 13:0_13:0LPC O-18:3LPC O-18:0TrifolinLPC O-18:12-(cyclopropylcarbonyl)-3-(4-fluoroanilino)acrylonitrileSM 8:0;2O/28:05-trans prostaglandin F2βLysine ButyrateAbametapirSebacic acidLPC 16:2-SN13-Methoxy prostaglandin F1αN-PhenylacetylglutamineMethyldopaLinustatinNicotinamide11(Z),14(Z),17(Z)-Eicosatrienoic acidPC 21:2_20:3Ohmefentanyl15-Deoxy-Δ12,14-prostaglandin J2-2-glycerol esterLPC 22:0N-AcetylornithineOleoyl ethanolamideN-(4-butyl-2-methylphenyl)-N'-[4-(4-methylpiperazino)phenyl]ureaPyridoxamineL-Pyroglutamic acid9-Oxo-ODEBiochanin A11β-Prostaglandin F2αAndrosteroneDeoxyguanosineSM 38:1;2OSM 8:1;2O/34:7PE O-15:1_18:2AcetylcholineSM 8:1;2O/34:8PE O-15:1_18:35-OxoETEN-LauroylsarcosineLPC 18:2-SN1Thymidine(±)8-HEPEPC O-19:0D-Fructose 6-phosphatePC O-19:13-phenyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-olα-LapachoneLPC O-16:1Proscillaridin A1-[3-nitro-4-(2-pyridylthio)phenyl]ethan-1-one1-[5-(2-phenyleth-1-ynyl)-2-thienyl]ethan-1-one oximeN-Arachidonoyl-L-serineHKKPC 20:4_20:5N-MethyllysineDL-StachydrineLinolelaidic Acid (C18:2N6T)(+/-)5(6)-EET Ethanolamide3'-Adenosine monophosphate (3'-AMP)2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acidEthyl oleatecis-gondoic acid13,14-dihydro-15-keto-tetranor Prostaglandin E2SM 33:2;2OPhe-Phe5-ethoxy-2-[(2,3,4,5,6-pentafluorobenzyl)thio]-1H-benzo[d]imidazoleMag (18:1)Methionine sulfoxideSenecioninep-HydroxybenzaldehydeLPC 17:2-SN11,3-DimethyluracilPalmitic Acid1-(4-benzylpiperazino)-2-(pyridin-2-ylamino)propan-1-oneLPC 14:1-SN116(R)-HETEPC 18:2_18:24-AminobiphenylDeoxycytidineWKKLPE 16:0SM 8:1;2O/36:1falseMaternal plasma metabolomic profiling of periparturient dairy cows supplemented with high-dose chromium propionate before calvingThis study contains untargeted LC-MS/MS metabolomic profiles of maternal plasma collected on the day of calving from Holstein dairy cows in the control and high-dose chromium propionate supplementation groups. Cows received either a basal total mixed ration without supplemental chromium propionate or the same ration supplemented with high-dose chromium propionate from 21 days before expected calving until parturition. Plasma samples were collected at calving and analyzed to characterize maternal metabolic responses associated with prepartum chromium propionate supplementation during the periparturient period.2026-09-262026-09-03MTBLS15538Com_12_negCom_15_negCom_16_negCom_73_negCom_85_negCom_86_negCom_139_negCom_143_negCom_156_negCom_231_negCom_281_negCom_306_negCom_316_negCom_322_negCom_350_negCom_532_negCom_536_negCom_565_negCom_595_negCom_650_negCom_756_negCom_1214_negCom_1217_negCom_1260_negCom_1401_negCom_1423_negCom_1446_negCom_1872_negCom_2892_negCom_4158_negCom_4232_negCom_6268_negCom_8713_negCom_8819_negCom_20_negCom_2808_negCom_8_negCom_33_negCom_26_negCom_56_negCom_168_negCom_874_negCom_240_negCom_7_negCom_908_negCom_485_negCom_1973_negCom_1481_negCom_10_negCom_1960_negCom_753_negCom_83_negCom_6454_negCom_77_negCom_3_negCom_5_negCom_6_negCom_13_negCom_29_negCom_48_negCom_51_negCom_57_negCom_61_negCom_72_negCom_76_negCom_80_negCom_104_negCom_113_negCom_114_negCom_116_negCom_123_negCom_140_negCom_152_negCom_161_negCom_180_negCom_185_negCom_221_negCom_230_negCom_235_negCom_242_negCom_250_negCom_269_negCom_297_negCom_313_negCom_336_negCom_337_negCom_340_negCom_378_negCom_389_negCom_444_negCom_448_negCom_465_negCom_482_negCom_505_negCom_506_negCom_517_negCom_539_negCom_547_negCom_573_negCom_580_negCom_593_negCom_596_negCom_601_negCom_605_negCom_607_negCom_615_negCom_633_negCom_641_negCom_668_negCom_676_negCom_682_negCom_706_negCom_725_negCom_736_negCom_760_negCom_780_negCom_816_negCom_822_negCom_826_negCom_827_negCom_841_negCom_846_negCom_868_negCom_886_negCom_904_negCom_923_negCom_973_negCom_984_negCom_986_negCom_1004_negCom_1059_negCom_1122_negCom_1132_negCom_1142_negCom_1151_negCom_1170_negCom_1172_negCom_1178_negCom_1188_negCom_1190_negCom_1231_negCom_1250_negCom_1299_negCom_1345_negCom_1348_negCom_1372_negCom_1385_negCom_1398_negCom_1415_negCom_1439_negCom_1452_negCom_1458_negCom_1465_negCom_1476_negCom_1520_negCom_1542_negCom_1589_negCom_1593_negCom_1618_negCom_1641_negCom_1666_negCom_1690_negCom_1702_negCom_1725_negCom_1744_negCom_1748_negCom_1780_negCom_1788_negCom_1790_negCom_1794_negCom_1821_negCom_1833_negCom_1838_negCom_1867_negCom_1874_negCom_1905_negCom_1912_negCom_1977_negCom_1985_negCom_2014_negCom_2036_negCom_2051_negCom_2083_negCom_2124_negCom_2127_negCom_2160_negCom_2185_negCom_2202_negCom_2268_negCom_2306_negCom_2317_negCom_2324_negCom_2342_negCom_2380_negCom_2398_negCom_2504_negCom_2522_negCom_2529_negCom_2642_negCom_2716_negCom_2734_negCom_2796_negCom_2801_negCom_2826_negCom_2901_negCom_2930_negCom_2937_negCom_2951_negCom_2970_negCom_2977_negCom_3031_negCom_3044_negCom_3061_negCom_3064_negCom_3069_negCom_3073_negCom_3076_negCom_3099_negCom_3128_negCom_3150_negCom_3253_negCom_3260_negCom_3307_negCom_3418_negCom_3453_negCom_3469_negCom_3483_negCom_3549_negCom_3554_negCom_3565_negCom_3566_negCom_3574_negCom_3607_negCom_3621_negCom_3628_negCom_3641_negCom_3677_negCom_3696_negCom_3708_negCom_3806_negCom_3821_negCom_3854_negCom_3855_negCom_3875_negCom_3882_negCom_3997_negCom_4028_negCom_4055_negCom_4083_negCom_4145_negCom_4279_negCom_4292_negCom_4323_negCom_4370_negCom_4463_negCom_4536_negCom_4629_negCom_4632_negCom_4679_negCom_4726_negCom_4798_negCom_4805_negCom_4819_negCom_4854_negCom_4871_negCom_4879_negCom_5051_negCom_5119_negCom_5210_negCom_5224_negCom_5268_negCom_5299_negCom_5306_negCom_5350_negCom_5355_negCom_5370_negCom_5478_negCom_5506_negCom_5524_negCom_5585_negCom_5643_negCom_5660_negCom_5702_negCom_5712_negCom_5737_negCom_5760_negCom_5818_negCom_5824_negCom_5874_negCom_5964_negCom_5965_negCom_5990_negCom_6030_negCom_6042_negCom_6047_negCom_6059_negCom_6066_negCom_6147_negCom_6153_negCom_6160_negCom_6195_negCom_6250_negCom_6269_negCom_6302_negCom_6326_negCom_6341_negCom_6444_negCom_6491_negCom_6514_negCom_6691_negCom_6725_negCom_6732_negCom_6820_negCom_6899_negCom_6903_negCom_6987_negCom_6993_negCom_7026_negCom_7093_negCom_7166_negCom_7224_negCom_7393_negCom_7417_negCom_7459_negCom_7513_negCom_7527_negCom_7540_negCom_7576_negCom_7599_negCom_7614_negCom_7644_negCom_7657_negCom_7737_negCom_7764_negCom_7988_negCom_8023_negCom_8085_negCom_8141_negCom_8221_negCom_8255_negCom_8306_negCom_8360_negCom_8502_negCom_8504_negCom_8557_negCom_8592_negCom_8616_negCom_8734_negCom_8766_negCom_8876_negCom_8879_negCom_8938_negCom_8985_negCom_9068_negCom_9091_negCom_9119_negCom_9171_negCom_9234_negCom_9274_negCom_9353_negCom_9406_negCom_9474_negCom_9479_negCom_9505_negCom_9541_negCom_9759_negCom_9794_negCom_9806_negCom_9821_negCom_10152_negCom_10166_negCom_10235_negCom_10281_negCom_10304_negCom_10309_negCom_10336_negCom_10390_negCom_10469_negCom_10502_negCom_10531_negCom_10540_negCom_10548_negCom_10593_negCom_10654_negCom_10745_negCom_10747_negCom_10817_negCom_10879_negCom_10889_negCom_10942_negCom_10943_negCom_11045_negCom_11052_negCom_11053_negCom_11236_negCom_11355_negCom_11364_negCom_11374_negCom_11520_negCom_11576_negCom_11578_negCom_11620_negCom_11639_negCom_11696_negCom_11753_negCom_11773_negCom_11949_negCom_12032_negCom_12134_negCom_12220_negCom_12239_negCom_12357_negCom_12366_negCom_12385_negCom_12415_negCom_12419_negCom_12465_negCom_12479_negCom_12508_negCom_12515_negCom_12559_negCom_12897_negCom_12901_negCom_12930_negCom_12977_negCom_13010_negCom_13133_negCom_13210_negCom_13300_negCom_13308_negCom_13321_negCom_13402_negCom_13409_negCom_13437_negCom_13498_negCom_13507_negCom_13513_negCom_13566_negCom_13664_negCom_13690_negCom_13790_negCom_13800_negCom_13809_negCom_13879_negCom_13907_negCom_13937_negCom_13946_negCom_13975_negCom_14061_negCom_14133_negCom_14274_negCom_14282_negCom_14360_negCom_14592_negCom_14659_negCom_14709_negCom_14855_negCom_14909_negCom_15056_negCom_15163_negCom_15183_negCom_15241_negCom_15289_negCom_15301_negCom_15369_negCom_15410_negCom_15413_negCom_15499_negCom_15595_negCom_15758_negCom_15777_negCom_15805_negCom_15815_negCom_15971_negCom_15993_negCom_16089_negCom_16162_negCom_16177_negCom_16184_negCom_16273_negCom_16327_negCom_16382_negCom_16414_negCom_16436_negCom_16437_negCom_16467_negCom_16554_negCom_16646_negCom_16685_negCom_16758_negCom_16778_negCom_16848_negCom_16874_negCom_16890_negCom_16891_negCom_16951_negCom_16973_negCom_17016_negCom_17031_negCom_17058_negCom_17077_negCom_17134_negCom_32_negCom_35_negCom_112_negCom_127_negCom_94_negCom_28_negCom_34_negCom_18_negCom_410_negCom_956_negCom_3298_negCom_23_negCom_321_negCom_1959_negCom_39_negCom_155_negCom_2105_negCom_688_negCom_456_negCom_266_negCom_10290_negCom_597_negCom_14604_negCom_333_negCom_1213_negCom_788_negCom_809_negCom_14943_negCom_141_negCom_5672_negCom_4345_negCom_963_negCom_5789_negCom_84_negCom_1897_negCom_1085_negCom_2296_negCom_2078_negCom_4501_negCom_4944_negCom_1634_negCom_223_negCom_2253_negCom_1267_negCom_1853_negCom_1431_negCom_695_negCom_4560_negCom_437_negCom_6658_negCom_1556_negCom_535_negCom_4542_negCom_446_negCom_2926_negCom_194_negCom_4458_negCom_3183_negCom_192_negCom_118_negCom_1717_negCom_40_negCom_120_negCom_52_negCom_24_negCom_1464_negCom_106_negCom_62_negCom_866_negCom_4414_negCom_11025_negCom_3958_negCom_983_negCom_6107_negCom_5499_negCom_11606_negCom_6202_negCom_1860_negCom_4710_negCom_4840_negCom_11386_negCom_13219_negCom_629_negCom_301_negCom_4317_negCom_2412_negCom_5348_negCom_8295_negCom_1277_negCom_19_negCom_2540_negCom_14_posCom_17_posCom_26_posCom_41_posCom_58_posCom_80_posCom_94_posCom_122_posCom_216_posCom_248_posCom_270_posCom_280_posCom_344_posCom_348_posCom_375_posCom_402_posCom_416_posCom_457_posCom_664_posCom_855_posCom_897_posCom_983_posCom_1001_posCom_1249_posCom_1279_posCom_1414_posCom_1420_posCom_1705_posCom_1824_posCom_2048_posCom_2416_posCom_2559_posCom_2954_posCom_3661_posCom_3670_posCom_4730_posCom_5117_posCom_6104_posCom_6360_posCom_8138_posCom_2_posCom_7_posCom_10_posCom_85_posCom_88_posCom_104_posCom_145_posCom_147_posCom_173_posCom_185_posCom_481_posCom_533_posCom_1232_posCom_3556_posCom_3811_posCom_5485_posCom_7246_posCom_9_posCom_47_posCom_53_posCom_61_posCom_64_posCom_65_posCom_69_posCom_71_posCom_77_posCom_83_posCom_108_posCom_114_posCom_128_posCom_132_posCom_146_posCom_152_posCom_186_posCom_192_posCom_222_posCom_242_posCom_257_posCom_268_posCom_274_posCom_276_posCom_291_posCom_295_posCom_308_posCom_332_posCom_333_posCom_335_posCom_364_posCom_399_posCom_406_posCom_408_posCom_410_posCom_424_posCom_428_posCom_429_posCom_441_posCom_443_posCom_454_posCom_455_posCom_469_posCom_513_posCom_550_posCom_572_posCom_578_posCom_586_posCom_595_posCom_597_posCom_626_posCom_627_posCom_634_posCom_656_posCom_687_posCom_700_posCom_702_posCom_733_posCom_735_posCom_741_posCom_765_posCom_794_posCom_821_posCom_854_posCom_867_posCom_883_posCom_898_posCom_916_posCom_940_posCom_941_posCom_942_posCom_956_posCom_959_posCom_960_posCom_967_posCom_991_posCom_1015_posCom_1047_posCom_1062_posCom_1065_posCom_1067_posCom_1083_posCom_1100_posCom_1116_posCom_1132_posCom_1139_posCom_1183_posCom_1189_posCom_1208_posCom_1220_posCom_1221_posCom_1234_posCom_1236_posCom_1251_posCom_1300_posCom_1313_posCom_1322_posCom_1340_posCom_1349_posCom_1359_posCom_1382_posCom_1408_posCom_1422_posCom_1428_posCom_1435_posCom_1459_posCom_1486_posCom_1487_posCom_1540_posCom_1550_posCom_1559_posCom_1585_posCom_1593_posCom_1610_posCom_1618_posCom_1646_posCom_1687_posCom_1688_posCom_1717_posCom_1724_posCom_1770_posCom_1790_posCom_1799_posCom_1814_posCom_1825_posCom_1827_posCom_1852_posCom_1878_posCom_1930_posCom_1945_posCom_1961_posCom_1972_posCom_1982_posCom_2018_posCom_2032_posCom_2033_posCom_2051_posCom_2056_posCom_2060_posCom_2101_posCom_2152_posCom_2169_posCom_2173_posCom_2184_posCom_2188_posCom_2204_posCom_2214_posCom_2233_posCom_2242_posCom_2255_posCom_2271_posCom_2312_posCom_2315_posCom_2324_posCom_2351_posCom_2390_posCom_2451_posCom_2478_posCom_2500_posCom_2514_posCom_2535_posCom_2570_posCom_2588_posCom_2609_posCom_2674_posCom_2691_posCom_2693_posCom_2709_posCom_2745_posCom_2747_posCom_2802_posCom_2803_posCom_2809_posCom_2823_posCom_2848_posCom_2871_posCom_2873_posCom_2912_posCom_2925_posCom_2937_posCom_2964_posCom_2972_posCom_2987_posCom_2994_posCom_3020_posCom_3031_posCom_3041_posCom_3072_posCom_3086_posCom_3107_posCom_3116_posCom_3138_posCom_3150_posCom_3178_posCom_3213_posCom_3231_posCom_3232_posCom_3234_posCom_3259_posCom_3267_posCom_3287_posCom_3291_posCom_3298_posCom_3304_posCom_3323_posCom_3449_posCom_3459_posCom_3480_posCom_3520_posCom_3523_posCom_3524_posCom_3525_posCom_3533_posCom_3534_posCom_3585_posCom_3592_posCom_3607_posCom_3619_posCom_3620_posCom_3668_posCom_3681_posCom_3700_posCom_3703_posCom_3721_posCom_3737_posCom_3748_posCom_3758_posCom_3771_posCom_3826_posCom_3832_posCom_3889_posCom_3891_posCom_3901_posCom_3908_posCom_3929_posCom_3953_posCom_3993_posCom_4010_posCom_4020_posCom_4059_posCom_4066_posCom_4113_posCom_4180_posCom_4248_posCom_4274_posCom_4334_posCom_4402_posCom_4419_posCom_4420_posCom_4494_posCom_4497_posCom_4549_posCom_4563_posCom_4578_posCom_4601_posCom_4603_posCom_4614_posCom_4688_posCom_4737_posCom_4780_posCom_4800_posCom_4802_posCom_4873_posCom_4878_posCom_4880_posCom_4891_posCom_4897_posCom_4900_posCom_4930_posCom_4941_posCom_4963_posCom_4986_posCom_4989_posCom_4999_posCom_5035_posCom_5138_posCom_5176_posCom_5213_posCom_5221_posCom_5230_posCom_5232_posCom_5264_posCom_5267_posCom_5295_posCom_5298_posCom_5357_posCom_5412_posCom_5479_posCom_5518_posCom_5550_posCom_5562_posCom_5604_posCom_5630_posCom_5635_posCom_5653_posCom_5689_posCom_5730_posCom_5766_posCom_5773_posCom_5803_posCom_5814_posCom_5821_posCom_5859_posCom_5861_posCom_5876_posCom_5919_posCom_5936_posCom_5952_posCom_5973_posCom_5979_posCom_5986_posCom_6007_posCom_6039_posCom_6085_posCom_6119_posCom_6138_posCom_6165_posCom_6248_posCom_6264_posCom_6289_posCom_6323_posCom_6369_posCom_6456_posCom_6474_posCom_6475_posCom_6495_posCom_6496_posCom_6524_posCom_6536_posCom_6567_posCom_6596_posCom_6724_posCom_6728_posCom_6735_posCom_6754_posCom_6778_posCom_6816_posCom_6889_posCom_6894_posCom_6895_posCom_6921_posCom_6929_posCom_6980_posCom_7052_posCom_7056_posCom_7073_posCom_7138_posCom_7215_posCom_7237_posCom_7293_posCom_7305_posCom_7314_posCom_7319_posCom_7354_posCom_7368_posCom_7375_posCom_7438_posCom_7446_posCom_7490_posCom_7518_posCom_7660_posCom_7681_posCom_7723_posCom_7729_posCom_7825_posCom_7835_posCom_7864_posCom_7934_posCom_7949_posCom_7950_posCom_8075_posCom_8093_posCom_8161_posCom_8202_posCom_8220_posCom_8254_posCom_8264_posCom_8272_posCom_8279_posCom_8280_posCom_8286_posCom_8308_posCom_8321_posCom_8333_posCom_8356_posCom_8423_posCom_8487_posCom_8509_posCom_8552_posCom_8586_posCom_8599_posCom_8637_posCom_8670_posCom_8727_posCom_8764_posCom_8778_posCom_8892_posCom_8915_posCom_8924_posCom_8928_posCom_8979_posCom_8998_posCom_9002_posCom_9026_posCom_9055_posCom_9070_posCom_9076_posCom_9111_posCom_9134_posCom_9139_posCom_9251_posCom_9293_posCom_9314_posCom_9319_posCom_9325_posCom_9387_posCom_9422_posCom_9432_posCom_9436_posCom_9479_posCom_9482_posCom_9514_posCom_9516_posCom_9531_posCom_9542_posCom_9700_posCom_9720_posCom_9730_posCom_9741_posCom_9746_posCom_9750_posCom_9755_posCom_9757_posCom_9764_posCom_9774_posCom_9805_posCom_9814_posCom_9827_posCom_9840_posCom_9872_posCom_9926_posCom_9933_posCom_9943_posCom_9948_posCom_9961_posCom_9974_posCom_9986_posCom_10122_posCom_10143_posCom_10218_posCom_10258_posCom_10261_posCom_10310_posCom_10357_posCom_10468_posCom_10524_posCom_10529_posCom_10555_posCom_10602_posCom_10610_posCom_10666_posCom_10732_posCom_10734_posCom_10736_posCom_10821_posCom_10853_posCom_10910_posCom_10928_posCom_10939_posCom_10970_posCom_10989_posCom_11029_posCom_11060_posCom_11147_posCom_11157_posCom_11165_posCom_11167_posCom_11172_posCom_11174_posCom_11190_posCom_11197_posCom_11253_posCom_11307_posCom_11327_posCom_11365_posCom_11485_posCom_11499_posCom_11596_posCom_11612_posCom_11620_posCom_11658_posCom_11674_posCom_11686_posCom_11690_posCom_11731_posCom_11787_posCom_11823_posCom_11971_posCom_12024_posCom_12026_posCom_12083_posCom_12090_posCom_12129_posCom_12159_posCom_12187_posCom_12192_posCom_12217_posCom_12317_posCom_12338_posCom_12378_posCom_12555_posCom_12605_posCom_12616_posCom_12657_posCom_12683_posCom_12685_posCom_12686_posCom_12711_posCom_12742_posCom_12748_posCom_12773_posCom_12776_posCom_12833_posCom_12837_posCom_12839_posCom_12903_posCom_12946_posCom_13061_posCom_13112_posCom_13116_posCom_13144_posCom_13187_posCom_13219_posCom_13355_posCom_13381_posCom_13393_posCom_13405_posCom_13587_posCom_13609_posCom_13624_posCom_13659_posCom_13736_posCom_13809_posCom_13907_posCom_13935_posCom_13991_posCom_14082_posCom_14084_posCom_14163_posCom_14230_posCom_14248_posCom_14396_posCom_14402_posCom_14406_posCom_14553_posCom_14676_posCom_14678_posCom_14743_posCom_14886_posCom_15018_posCom_15023_posCom_15024_posCom_15040_posCom_15077_posCom_15081_posCom_15088_posCom_15105_posCom_15120_posCom_15185_posCom_15382_posCom_15395_posCom_15402_posCom_15501_posCom_15509_posCom_15551_posCom_15692_posCom_15761_posCom_15777_posCom_15789_posCom_15828_posCom_15846_posCom_15916_posCom_15942_posCom_15945_posCom_16002_posCom_16028_posCom_16067_posCom_16207_posCom_16253_posCom_16302_posCom_16316_posCom_16322_posCom_16370_posCom_16544_posCom_16616_posCom_16623_posCom_16653_posCom_16692_posCom_16825_posCom_16855_posCom_16920_posCom_17055_posCom_17160_posCom_17161_posCom_17185_posCom_17234_posCom_17285_posCom_17337_posCom_17593_posCom_17731_posCom_17736_posCom_17917_posCom_17937_posCom_17942_posCom_17945_posCom_18030_posCom_18177_posCom_18276_posCom_18441_posCom_18479_posCom_18543_posCom_18587_posCom_18981_posCom_19046_posCom_19205_posCom_19231_posCom_19333_posCom_19338_posCom_19573_posCom_19733_posCom_19780_posCom_19896_posCom_20011_posCom_20065_posCom_20119_posCom_20289_posCom_20373_posCom_20416_posCom_20443_posCom_20583_posCom_20625_posCom_20842_posCom_21019_posCom_21032_posCom_21052_posCom_21099_posCom_21118_posCom_21134_posCom_30_posCom_148_posCom_159_posCom_320_posCom_322_posCom_385_posCom_444_posCom_492_posCom_525_posCom_527_posCom_801_posCom_818_posCom_871_posCom_900_posCom_923_posCom_1005_posCom_1086_posCom_1101_posCom_1235_posCom_1492_posCom_1539_posCom_1692_posCom_1694_posCom_1760_posCom_1940_posCom_1977_posCom_2007_posCom_2066_posCom_2096_posCom_2106_posCom_2109_posCom_2220_posCom_2239_posCom_2289_posCom_2719_posCom_2825_posCom_2835_posCom_2852_posCom_3136_posCom_3548_posCom_3552_posCom_3805_posCom_3840_posCom_3903_posCom_3977_posCom_4032_posCom_4050_posCom_4097_posCom_4177_posCom_4356_posCom_4555_posCom_4617_posCom_4887_posCom_4933_posCom_5784_posCom_5807_posCom_5884_posCom_6832_posCom_7621_posCom_7861_posCom_8226_posCom_8357_posCom_8771_posCom_9099_posCom_9172_posCom_9357_posCom_9917_posCom_10098_posCom_10461_posCom_11932_posCom_12116_posCom_12382_posCom_12510_posCom_13687_posCom_14156_posCom_14567_posCom_15011_posCom_15116_posCom_15446_posCom_18455_posCom_20417_posCom_20809_posCom_20825_posCom_20855_posCom_21005_pos