MetaboLights

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LC-MS data were processed using Progenesis QI v3.0 for baseline filtering, peak detection, integration, retention-time correction, and peak alignment. Metabolite features were putatively annotated by matching MS and MS/MS information against the Human Metabolome Database (HMDB), METLIN, and the Majorbio self-compiled database. A mass tolerance of <10 ppm was used for MS matching, together with MS/MS spectral information. Metabolite assignments were regarded as putative annotations unless confirmed using authentic standards.MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseChromatographic separation was performed using an ACQUITY UPLC system equipped with an ACQUITY UPLC HSS T3 column (100 mm × 2.1 mm, 1.8 μm; Waters, USA). Mobile phase A consisted of water/acetonitrile (95:5, v/v) containing 0.1% formic acid, and mobile phase B consisted of acetonitrile/isopropanol/water (47.5:47.5:5, v/v/v) containing 0.1% formic acid. The flow rate was 0.40 mL/min, the column temperature was maintained at 45 °C, and the injection volume was 10 μL.Untargeted cecal metabolomic profiling in MC903-induced atopic dermatitis-like mice orally administered live or heat-killed Ligilactobacillus salivarius Ls.0403.Duo KeaiPeking Universitycecal contentmass spectrometry assayApproximately 20 ± 5 mg of cecal content was weighed into a 2 mL centrifuge tube containing a 6 mm grinding bead. Metabolites were extracted with 400 μL methanol/water (4:1, v/v) containing internal standards, including L-2-chlorophenylalanine at 0.02 mg/mL. Samples were homogenized for 6 min at -10 °C and 50 Hz, sonicated for 30 min at 5 °C and 40 kHz, incubated at -20 °C for 30 min, and centrifuged at 13,000 × g for 15 min at 4 °C. The supernatant was transferred to LC-MS sample vials. Equal aliquots of the sample extracts were pooled to prepare quality-control samples.Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS15541Xinxin Wang. Guizhou Medical University. wxx_999w@163.com.Guzhen Cui. Guiyang Medical University. cuiguzhen@gmc.edu.cn.Raw SCIEX WIFF data were imported into Progenesis QI v3.0 (Waters Corporation, Milford, USA) for subsequent data processing.Groupkeaiduoduo998@126.comCecal contents were collected from mice at the experimental endpoint and stored at -80 °C until metabolomic analysis. Samples were obtained from the Blank, Model, live Ls.0403, and heat-killed Ls.0403 groups, with six biological replicates per group.MetabolomicsMetabolomicsheat-killed bacteriaMus musculusuntargeted metabolomicsCecal contentcecal metabolomicsuntargeted analysisatopic dermatitisWaters ACQUITY UPLC systemgut-skin axisAB SCIEX TripleTOF 6600Ligilactobacillus salivariusMetabolomicsheat-killed bacteriaMus musculusuntargeted metabolomicsCecal contentcecal metabolomicsuntargeted analysisatopic dermatitisWaters ACQUITY UPLC systemgut-skin axisAB SCIEX TripleTOF 6600Ligilactobacillus salivariusMass spectrometric detection was performed using an AB SCIEX TripleTOF 6600 mass spectrometer equipped with an electrospray ionization source. Data were acquired separately in positive and negative ionization modes over an m/z range of 50-1200. Ion Source Gas 1 and Ion Source Gas 2 were each set to 50 psi, curtain gas was set to 35 psi, and the source temperature was 500 °C. The ion-spray voltage was 5500 V in positive mode and -4500 V in negative mode. The declustering potential was 80 V, and the collision energy was 40 ± 20 eV for MS/MS acquisition.1,7-OctadieneThr-PheIle-ThrBolandiolLeu-ProSaikosaponin DIsopropanolamineArgininosuccinic AcidIle-Lys2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic AcidIndole-3-CarbinolApigenin 7-[Rhamnosyl-(1->2)-Galacturonide]N1,N10-DicoumaroylspermidineSchidigeragenin CAspartame3Beta-Hydroxy-5-Cholenoic AcidHistidylvaline2-Anthraquinonesulfonic AcidN(Tele)-MethylhistaminiumN6,N6,N6-Trimethyl-L-LysineL-HistidineHistidylprolineVal-TrpOctanoyl-L-Homoserine LactoneAnisperimus25,26-Dihydroxyvitamin DL-ProlineKukoamine DHydromorphoneMethyl Pyropheophorbide-ALeu-AspPe(Pgd2/P-18:0)6-ThioguanosineApstatinCasuarine 6-Alpha-D-GlucosideDipropylamine3Beta-Hydroxy-4Beta-Methyl-5Alpha-Cholest-7-Ene-4Alpha-Carboxylate4,6-Diamino-5-Formamidopyrimidine4-HydroxybenzaldehydeN2-AcetylornithineTyr-Ile9,10,13-Trihome8-Aminooctanoic AcidSecalciferolPg(Lte4/I-22:0)Estradiol2-S-Glutathionyl Caftaric AcidFiribastatN-AcetylsphinganineOctapropylene GlycolUndeca-4,9-Dienoic AcidArg-ValAmoxicilloylLiensinineMilbemycin Alpha10Octadecenedioic Acid6-(Alpha-D-Glucosaminyl)-1-Phosphatidyl-1D-Myo-InositolSoyasaponin BbDihydroguaiaretic AcidDocetaxolAla-PheFlavin MononucleotideSarmentosinTresperimus3,7-Dihydroxy-12-Oxocholanoic AcidMiglitolD-(+)-MaltoseButaprostHistidyllysineSoyasaponin BgTetrabenazineAdenosine Monophosphate23S,25,26-Trihydroxyvitamin D3N-AcetylcadaverineIsoetharinegamma-Glu-GluOleamide4-O-Methyl-A-D-Glucosyl-(1->2)-B-D-Xylosyl-(1->4)-D-XyloseAlgestone4-Pentenoic AcidDg(18:1/18:2)1-[Ethyl-(6-Hydrazinylpyridazin-3-Yl)Amino]Propan-2-OlLeukotriene B4 DimethylamideBis(2-Ethylhexyl) AdipateDehydrosoyasaponin IVindoline3,11,12-Trihydroxy-1(10)-Spirovetiven-2-OneN-Eicosapentaenoyl GlycineGuanosine2-Buten-1-OlLeu-ValMethyl Linoleate3,5-Di-Tert-Butyl-4-Hydroxybenzyl Alcohol8-HydroxydaidzeinCevadineCytochalasin BNeomangiferinAzukisapogenolGlyceryl PalmitoleateDi-N-Octyl PhthalatePhe-GlyCaffeic Acid Phenethyl EsterTetradecanoylcarnitineRavtansineTyr-ThrAcrasinPongamolHesperetin 7-NeohesperidosideBiliverdinLys-Ile(3A,5B,7A)-23-Carboxy-7-Hydroxy-24-Norcholan-3-Yl-B-D-Glucopyranosiduronic AcidGentamicin CGlyceryl MonolinoleateEriojaposide BAlpha,Gamma-OnoceradienedioneAnnomuricatin BBoldenone Undecylenate(3Beta,5Alpha,6Beta,9Alpha,22E,24R)-23-Methylergosta-7,22-Diene-3,5,6,9-TetrolAnnomuricatin ANeamineUridineN-Acetylhexosamine12-Ketodeoxycholic AcidSmilageninHydroxylated Lecithin27-Hydroxyisomangiferolic AcidN-Nervonoyl CysteineTyr-GlnArg-ProIsovaleronitrileVomifoliol 9-[Glucosyl-(1->4)-Xylosyl-(1->6)-Glucoside]Draflazine(6E,9E)-Tetradeca-6,9-DienedioylcarnitineProstaglandin A2RutaecarpinePhe-SerAlpha,Beta-TrehaloseEpsilon-CaprolactamPhe-ThrTyr-GluIle-GluStigmasterolAsp-GluBeta-1,4-Mannosyl-N-AcetylglucosaminePhthalic AnhydrideGlycodeoxycholate SulfateNummularine BTauro-Beta-Muricholic AcidNummularine AMethylimidazoleacetic AcidL-CarnitineDiethanolamineCeruleninPalmitoleamideThiamineIle-Gly8Z,11Z-Eicosadienoic AcidAcetyl Tributyl Citrate4-Hydroxy-4-(3-Pyridyl)-Butanoic AcidIsobutylideneDiisononyl PhthalateDodecanoylcarnitinePro-IleHis-IleBis(2-Ethylhexyl) PhthalateGlycoursodeoxycholic AcidTacrolimusL-TyrosineGlu-TrpOleanolic Acid6-Hydroxydodeca-8,10-Dienoic AcidPinolenic AcidTalatisaminePhe-Pro2'-Deoxymugineic AcidL-PhenylalanineArgatrobanDihydrosinapic AcidTetrahcaClomipramineDg(Lte4/A-17:0/0:0)Dg(6 Keto-Pgf1Alpha/2:0/0:0)EtimicinCis-4-Hydroxy-D-ProlineGanoderenic Acid EIsovitexin 2''-O-(6'''-Feruloyl)Glucoside6-HydroxysandoricinCratoxyloneMerodesmosineEcgonineProstaleneSpermidineSphingosinePectenotoxin 71(2H)-Isoquinolinone(2Z)-5-Hydroxydec-2-Enedioic AcidPelubiprofen2-Hydroxycinnamic Acid5B-Cyprinol SulfateDiisobutyl PhthalatePevonedistatVal-ProThr-LysMomordicininD-(+)-TrehaloseSer-IleIle-Hisgamma-Glu-Phe2-(5,8-Tetradecadienyl)CyclobutanoneHebevinoside IxGinsenoside RoUrocanic Acid(5E)-7-[3,5-Dihydroxy-2-(3-Hydroxyoctyl)Cyclopentyl]Hept-5-Enoylcarnitine7-Oxoprostaglandin I2Soyasaponin Beta-ACabergolineL-ProlinamideVinaginsenoside R6Semilepidinoside ANicoboxil(23S)-23,25-Dihdroxy-24-Oxovitamine D3 23-(Beta-Glucuronide)Umbelliferone1H-Pyrazolo[3,4-D]Pyrimidin-4-AmineZearalenoneTrans-3-Indoleacrylic AcidBufotalinGinsenoside Rg3Guanine1-Monolinoleoyl-Rac-GlycerolSabinyl AcetateOctadecanamideDiisooctyl PhthalateMalabaricone B3-Hydroxytetradeca-8,10,12-TrienoylcarnitineZoniporideN-Oleoyl AsparagineMg(18:1(9Z)/0:0/0:0)11-Dehydro-Thromboxane B2Beta-Elemolic Acid1-EthylaziridinePrednisoloneCreatinine4-Amino-1-[(2R,5R)-5-(Aminomethyl)-3,4-Dihydroxyoxolan-2-Yl]Pyrimidin-2-OneIndole-3-CarboxaldehydeBetulinic AcidHydroxyrubicin(5Z)-(15S)-11Alpha-Hydroxy-9,15-Dioxoprostanoate(-)-Jasmonic AcidXanthosineTrans-Vaccenic Acid7Alpha-Hydroxy-3-Oxochol-4-En-24-Oic AcidSchisandrin BDelta-Dodecalactone7-MethylguanineTrimethylamineGln-ValDg(18:2/20:4)Stearidonic AcidPgf2A Ethanolamide1H-Indole-3-Carboxylic AcidTanacetol BHeliotridineApocarotenalHyodeoxycholic Acid7,8-Dihydrovomifoliol 9-[Rhamnosyl-(1->6)-Glucoside]N-Palmitoyl-D-Sphingosine(13R,14R)-7-Labdene-13,14,15-Triol3-KetosphinganineCortisolTyr-PhePhe-ValVal-ArgUrobilinHygromycin BL-AlanineLys-ProAla-ProTyr-Hyp(2S)-3-Hydroxy-1-[(2S)-Pyrrolidine-2-Carbonyl]Pyrrolidine-2-Carboxylic AcidPipecolic Acid9,10-Dihydrojasmonic AcidDynorphin B (6-9)N-Lauroyl LysineGinsenoside Rh34-Tert-Butylcyclohexyl AcetateAlpha-Tocopheryl AcetateCytidine3-Oxo-4,6-Choladienoic Acid17-AminogeldanamycinIpragliflozinCorymbosideGuanosine 3',5'-Cyclic Monophosphate1,3-OctadieneApramycinBenzofuran3-(3,4-Dihydroxyphenyl)-2-Hydroxypropanoic AcidLysope(15:0/0:0)MesobilirubinogenGanoderol APyridostigmineL-LysineTauroursodeoxycholic Acid6Beta-HydroxytestosteroneMilbemycin Beta1Glabrin DGalactosylhydroxylysine(+/-)-2-Methylthiazolidine3,10-DihydroxydodecanoylcarnitineCis-4-Hydroxyequol2,4,12-Octadecatrienoic Acid Isobutylamidebeta-Asp-Leu(2E)-4-HydroxyhexadecenoylcarnitineEmmolic AcidOctylamine5Beta-Cholestane-3Alpha,7Alpha,24,26-TetrolPhenylpyruvic AcidDeoxyspergualinArg-IleSphinganine(10E)-8-Hydroxydodec-10-EnoylcarnitineLeu-ArgN,N-Diallyl-Tyrosyl-Aminoisobutyryl-Aminoisobutyryl-Phenylalanyl-LeucineHis-gamma-GluThymine17-Dimethylaminogeldanamycin(3Beta,5Alpha,6Beta,7Alpha,22E,24R)-Ergosta-8,22-Diene-3,5,6,7-TetrolStercobilinRockogeninVerdamicinApcN-(6-Cyano-3-Hydroxy-2,2-Dimethyl-3,4-Dihydrochromen-4-Yl)-N-MethylethanesulfonamideSoyasaponin Gamma-A2',7-Dihydroxy-4'-Methoxy-8-PrenylflavanOxazineCrassostrea SecocarotenoidEpothilone B20-Hydroxy-Leukotriene E4Acetylshikonin(+/-)-2,2,6-TrimethylcyclohexanoneXanthohumolJanthitrem E1-Linoleoyl-Sn-Glycero-3-PhosphorylcholineNaltrexoneAdluponeDibutyl SebacatePro-LeuGly-Pro-GluDibutyl Phthalate5B-Cholestane-3A,7A,12A,23R,25-PentolDemethylphylloquinolL-SaccharopineDidemethylcitalopramAndrographolide(4Z)-Dec-4-EnedioylcarnitinePhe-TrpNetilmicinL-LeucinePhloionolic AcidCalcifediol LactoneThiamine Monophosphate[8]-GingerolAncistrocladinePrednisoneZanthodiolineGuanidinopropionic AcidN6-Succinyl AdenosineForskolinWilforlide ADocosatrienoic AcidLucidenolactoneDihydroceramide5'-N-Methylcarboxamidoadenosinegamma-Glu-Leu5-HydroxyfluvastatinSirolimusStearoyl EthanolamideArachidonoylcarnitine5-Nonadecyl-1,3-BenzenediolPseudobaptigeninThr-ValTridecanedioic AcidTyr-TrpL-Threonic Acid-1,4-LactonePe(Pge1/P-18:0)LincomycinLinoleamideLeukotriene C5Phosphate7-MethylthioheptyldesulfoglucosinolateObtusifolinPro-Arg(3R,4R,5R)-3-Fluoro-5-(Hydroxymethyl)Oxolane-2,3,4-TriolNeuromedin N4-Trimethylammoniobutanoate17-HydroxyprogesteroneCanesceinTenuazonic AcidDopaminePregn-4-En-20-Yn-3-One, 17-Hydroxy-2-(Hydroxymethyl)-, (2Alpha,17Alpha)-3-Hydroxyheptadecanoylcarnitine3,8-DihydroxydodecanoylcarnitinePisumsaponin IN-OleoylethanolamineDomoic AcidAb-MecaFlavin Adenine DinucleotideN1,N8-DiacetylspermidineMeteneprostIsopyridoxal(Z)-Resveratrol 4'-Glucoside2-Hydroxy-6-AminopurineSoyasapogenol BSoyasapogenol CErythrono-1,4-LactoneBacoside AN-Alpha-Benzoyl-L-ArginineN-Linoleoyl GabaL-ValineUracilCedrolPipericineTetracosahexaenoic AcidPicolinic AcidEpanololAllo-3Alpha-Tetrahydrocortisol3A,7A,12A,19-Tetrahydroxy-5B-Cholanoic Acid3-Benzyl-5-(6-Carboxyhexyl)-1-(2-Cyclohexyl-2-Hydroxyethylamino)HydantoinPe(Pgd1/P-18:0)CreatineRac-5,6-Epoxy-Retinoyl-Beta-D-GlucuronideMethyl ProtodioscinDl-Allylglycine(3Beta,5Alpha)-4,4-Dimethylcholesta-8,14,24-Trien-3-OlPhytosphingosine17-N,N-Diethylcarbamoyl-4-Methyl-4-Azaandrostane-3-OneCervonoyl Ethanolamide13-Nor-6-Eremophilene-8,11-DionePro-AlaCytosine(4Z,7Z,10Z,13Z,16Z)-19,20-Dihydroxydocosa-4,7,10,13,16-PentaenoylcarnitineN-Acetyl-Neuraminic AcidMacrolactin-ALinalool (8-Hydroxydihydro-)12-Hydroxyicosanoic AcidDihydrotestosterone Diglucuronide1-Hydroxy-2,12,15-Heneicosatrien-4-OneIle-LeuMulberrofuran EDihydro-4,6-Dimethyl-2-(1-Methylethyl)-4H-1,3,5-DithiazineCoumarinCeanothine EN-Stearoyl GabaTyr-Arg3-Amino-3-(4-Hydroxyphenyl)PropanoatePhe-ArgHypoxanthineStrophanthidinHomoserine3'-KetolactoseLeu-PheGly-Ser-Pro-Met-Phegamma-Glu-Ala2-ArachidonoylglycerolPristimerinTriphenyl PhosphatePeperinic AcidThr-Ile1-Aminocyclopentanecarboxylic AcidMelagatran2,6-DihydroxypurineGalactosylsphingosineCytarabineSec-O-GlucosylhamaudolNonadecylresorcinol Glucuronide2-Piperidinecarboxamide, 1-Butyl-N-(4-Hydroxy-2,6-Dimethylphenyl)-11Alpha-HydroxyprogesteroneCis-And Trans-Ethyl 2,4-Dimethyl-1,3-Dioxolane-2-AcetateSer-Pro1-Phenylethanol2-Amino-3-Methylbenzoic AcidLys-Ala-ArgCynarasaponin FCavipetin CTriethyl PhosphateHexaethylene GlycolN-Acetyl-N-Formyl-5-MethoxykynurenamineEthambutolDodecylbenzene7-OxocholesterolIle-ArgSulfolithocholylglycineTyr-LeuPhysapruin AAminocaproic Acid11-{3,4-Dimethyl-5-[(1E)-Pent-1-En-1-Yl]Furan-2-Yl}Undecanoyl-CoaAsp-Leu2-Hydroxystearic AcidNedocromil2,4,6-Phenanthrenetriol 2-O-B-D-GlucosideCalphostin CCamellianin ACalcitroic AcidDimethylethanolamineTris(2-Chloropropyl) PhosphateN-Stearoyl Serine3-Aminoadipic AcidTrp-LeuLys-GlyVitamin EAla-GluCystinylglycineCamelledionolEugenyl GlucosideAlpha-Tocopherol AcetateLpe(18:1)PantethineMicronomicinPropionaldehydePentamethylchromanolDeoxycholylglutamic AcidCrenolanib7A,12A-Dihydroxy-3-Oxo-4-Cholenoic AcidLysopc(16:0/0:0)Arg-Pro-ProPyroglutamic AcidLys-Asp-Glu-Leu(R)-1-O-[B-D-Apiofuranosyl-(1->2)-B-D-Glucopyranoside]-1,3-OctanediolCucurbitacin IElocalcitolL-(+)-Arginine14-HdoheMaltotriose2,2,4-Trimethyl-1,3-Pentanediol DiisobutyratePc(32:1)24,24-DfhvL-MethionineXi-2,3-Dihydro-2-Oxo-1H-Indole-3-Acetic AcidMyricanol 5-Beta-SophorosideSoyasaponin V4-(4'-O-Acetyl-Alpha-L-Rhamnosyloxy)Benzaldehyde2-(4-Nitrobenzylidene)MalononitrileAntcin KIle-AlaN-Myristoyl ArgininePalmitoyl Ethanolamide27-NorcholestanehexolAmafoloneMethyl (R)-9-Hydroxy-10-Undecene-5,7-Diynoate GlucosideUrothiongamma-Glu-ValOridonin4Alpha-Carboxy-4Beta-Methyl-5Alpha-Cholesta-8-En-3Beta-OlTrilostaneDeoxycholylprolineTyr-ProPenitrem DIle-TrpMenthyl Ethylene Glycol CarbonateCholine GlycerophosphateMethyl LinolenateEchinocystic AcidN-Myristoyl Threonine5,7-Dihydroxyflavone1-PyrrolineScopolamineLumisterol 3Deoxyadenosine MonophosphateIle-MetN-AcetylputrescineGinsenoside F3Ginsenoside F1Pro-ValS-Adenosylmethionine4-Androstenediol7-Ketodeoxycholic AcidGamma-Glutamyl-Se-MethylselenocysteineMaslinic AcidCedazuridineSalicyluric Beta-D-GlucuronideCholineBenzyl ButyrateVal-ThrEnkephalinamide-Leu, Ala(2)-Tauroursocholic AcidAcetylcholineLpe(18:2)L-Threo-3-Phenylserine2,3-DihydrobenzofuranLeu-GlnPe(14:0/16:0)5-(10,13-Nonadecadienyl)-1,3-BenzenediolDigitoxigenin5-(4'-Hydroxyphenyl)-Gamma-Valerolactone 4'-SulfateCyclosquamosin GDifluprednateN-OctadecylamineHexadecenalGlu-Thr16-B1-Phytoprostane2-Hydroxy-2,6,6-Trimethylcyclohexanone1,2-AnhydridoniveusinIndoline2-(Methylenebutyl)-CyclopropanePalmitoyl Ara-CMomordin ISoyasaponin A3Pg(Lte4/I-19:0)N,N-Dimethylarginine1-ArachidonoylglycerolVal-Gluo-TyrosineAla-LysO-Acetyl-L-Serine7Alpha,12Alpha-Dihydroxycholest-4-En-3-OneAcacetin(+/-)-2-(2-Methylpropyl)ThiazolidinePalmitoylcarnitineN-L-Gamma-Glutamyl-L-LeucineMomordin BMeta-O-Dealkylated Flecainide3A,6B,7B,12B-Tetrahydroxy-5B-Cholanoic AcidPro-AspLacto-N-Biose IFluphenazineMisoprostol AcidDesacetylcefotaximeDiosgenin4-Cholesten-7Alpha,12Alpha,24-Triol-3-One2'-DeoxyadenosineSarsasapogenin9-OctadecenamideGln-PhePhe-PheTyr-Val(R)-EquolHis-Tyr1,3-Dicyclohexylurea4-Chlorobenzaldehyde3-HydroxybutyrylcarnitineLpc(18:1)Auda3-Beta-Hydroxy-4-Beta-Methyl-5-Alpha-Cholest-7-Ene-4-Alpha-CarboxylateGly-TyrLinoleoyl EthanolamideMacelignanDiisobutyl AdipateN-((Hexahydro-1-Azepinyl)Carbonyl)-Leucyl(1-Methyl)-Tryptophyl-TryptophanPyrrolidineAsn-LeuBaicalin3A,6B,7B,12A-Tetrahydroxy-5B-Cholanoic Acid1-Acetoxy-2-Hydroxy-16-Heptadecyn-4-OnePro-ProN2-Succinyl-L-OrnithineMonoelaidin(R)-Sulcatol9-ArabinofuranosyladenineMarinobufagenin12-Hydroxyjasmonic Acid Glucoside3'-AmpArmillaramideDg(Pgf1Alpha/0:0/A-21:0)5-HydroxyhexadecanoylcarnitinePentaethylene Glycol13,16-Docosadienoic Acid2-Hydroxy-6-Pentadecylbenzoic AcidSonchuionoside C1-1-Leu-Pro-ProLeu-GlyN-Docosahexaenoyl MethionineTobramycinDaidzeinMestranolGlucosylsphingosineHistidylleucineTaurodeoxycholic Acid5-Pentyl-2-Furanoctanoic AcidfalseUntargeted cecal metabolomic profiling in MC903-induced atopic dermatitis-like mice orally administered live or heat-killed Ligilactobacillus salivarius Ls.0403This project characterizes cecal metabolic profiles in an MC903-induced atopic dermatitis-like mouse model following oral administration of live or heat-killed Ligilactobacillus salivarius Ls.0403. Cecal content samples were collected from four experimental groups, including Blank, Model, live Ls.0403, and heat-killed Ls.0403 groups, with six biological replicates per group. Untargeted liquid chromatography-mass spectrometry was performed in both positive and negative ionization modes to characterize treatment-associated changes in cecal metabolic profiles.2026-09-032026-09-03MTBLS15541HMDB0002179HMDB0062193HMDB0257416HMDB0034267HMDB0255635HMDB0254358HMDB0259169HMDB0257975HMDB0000167HMDB0252766HMDB0032293HMDB0011649HMDB0000148HMDB0001151HMDB0006833HMDB0029935HMDB0000833HMDB0003459HMDB0260392HMDB0250357HMDB0000169HMDB0000215HMDB0029944HMDB0011738HMDB0253042HMDB0029123HMDB0304294HMDB0034266HMDB0028815HMDB0039110HMDB0039721HMDB0061133HMDB0248933HMDB0062708HMDB0001124HMDB0001068HMDB0001401HMDB0001000HMDB0254505HMDB0252849HMDB0000868HMDB0247893HMDB0060545HMDB0060453HMDB0001090HMDB0000286HMDB0006591HMDB0000574HMDB0028934HMDB0302563HMDB0000288HMDB0000489HMDB0003553HMDB0254834HMDB0247051HMDB0028683HMDB0000767HMDB0028818HMDB0040137HMDB0042005HMDB0060468HMDB0000060HMDB0246049HMDB0247628HMDB0000812HMDB0000289HMDB0030564HMDB0034774HMDB0001182HMDB0035036HMDB0000131HMDB0000202HMDB0257989HMDB0247415HMDB0001314HMDB0062599HMDB0012289HMDB0028966HMDB0002706HMDB0341073HMDB0012247HMDB0041337HMDB0006766HMDB0060493HMDB0000195HMDB0304219HMDB0006344HMDB0000017HMDB0028922HMDB0000071HMDB0304930HMDB0028979HMDB0258911HMDB0038357HMDB0010317HMDB0030317HMDB0028876HMDB0062223HMDB0036047HMDB0251757HMDB0031897HMDB0041217HMDB0001385HMDB0028832HMDB0255007HMDB0032880HMDB0000072HMDB0028986HMDB0252536HMDB0125148HMDB0012204HMDB0259044HMDB0257574HMDB0061881HMDB0011174HMDB0036296HMDB0028920HMDB0011719HMDB0247529HMDB0014887HMDB0028848HMDB0028725HMDB0028919HMDB0014356HMDB0003447HMDB0013609HMDB0041446HMDB0029156HMDB0259943HMDB0033592HMDB0301822HMDB0265891HMDB0246202HMDB0029131HMDB0274814HMDB0304912HMDB0005771HMDB0031857HMDB0000755HMDB0254218HMDB0259056HMDB0252124HMDB0029335HMDB0303757HMDB0247071HMDB0013059HMDB0250367HMDB0059763HMDB0001863HMDB0038728HMDB0003426HMDB0000118HMDB0028822HMDB0028976HMDB0060336HMDB0029134HMDB0059933HMDB0249397HMDB0012496HMDB0244237HMDB0039564HMDB0000423HMDB0259877HMDB0011170HMDB0252432HMDB0060818HMDB0029645HMDB0000706HMDB0030521HMDB0029581HMDB0000893HMDB0031535HMDB0010314HMDB0250945HMDB0015212HMDB0256234HMDB0283285HMDB0030401HMDB0028998HMDB0033375HMDB0010337HMDB0002085HMDB0034327HMDB0275335HMDB0037562HMDB0254445HMDB0037452HMDB0015459HMDB0004186HMDB0240503HMDB0029388HMDB0253833HMDB0033356HMDB0246890HMDB0253872HMDB0250486HMDB0252339HMDB0253033HMDB0253040HMDB0000763HMDB0028914HMDB0251473HMDB0040684HMDB0259993HMDB0247652HMDB0029181HMDB0240563HMDB0304567HMDB0041201HMDB0266616HMDB0033230HMDB0240687HMDB0038361HMDB0301976HMDB0242178HMDB0030868HMDB0060828HMDB0031172HMDB0037577HMDB0031656HMDB0033142HMDB0003072HMDB0340675HMDB0010410HMDB0251322HMDB0262591HMDB0040048HMDB0244495HMDB0031367HMDB0029306HMDB0000375HMDB0032573HMDB0041737HMDB0034927HMDB0000954HMDB0250244HMDB0015078HMDB0040778HMDB0302539HMDB0248838HMDB0013713HMDB0240499HMDB0246226HMDB0256384HMDB0029094HMDB0030525HMDB0240539HMDB0015321HMDB0033990HMDB0303454HMDB0062482HMDB0256643HMDB0240698HMDB0036856HMDB0035191HMDB0251162HMDB0243505HMDB0006285HMDB0301779HMDB0033207HMDB0000847HMDB0302135HMDB0002670HMDB0303040HMDB0004611HMDB0254199HMDB0241715HMDB0040441HMDB0003252HMDB0252709HMDB0006868HMDB0259626HMDB0112083HMDB0002121HMDB0248452HMDB0030667HMDB0041965HMDB0246020HMDB0304821HMDB0001938HMDB0004825HMDB0242008HMDB0031715HMDB0030567HMDB0248069HMDB0253688HMDB0034265HMDB0247405HMDB0253250HMDB0256138HMDB0012452HMDB0033976HMDB0015129HMDB0035140HMDB0002059HMDB0032018HMDB0015152HMDB0002982HMDB0031786HMDB0030611HMDB0040568HMDB0061643HMDB0038472HMDB0032609HMDB0258509HMDB0255425HMDB0033986HMDB0250029HMDB0041583HMDB0005781HMDB0033481HMDB0247290HMDB0340800HMDB0032829HMDB0253144HMDB0000399HMDB0247954HMDB0254173HMDB0029338HMDB0029892HMDB0252456HMDB0289252HMDB0278512HMDB0032797HMDB0060745HMDB0037926HMDB0276784HMDB0030524HMDB0255621HMDB0032719HMDB0000792HMDB0301851HMDB0041997HMDB0252731HMDB0036804HMDB0029676HMDB0250242HMDB0253219HMDB0269432HMDB0253156HMDB0257690HMDB0252352HMDB0258525HMDB0259834HMDB0060710HMDB0254886HMDB0240708HMDB0015468HMDB0296946HMDB0002513HMDB0031884HMDB0302107HMDB0034535HMDB0000933HMDB0011134HMDB0258477HMDB0035865HMDB0301912HMDB0006001HMDB0000903HMDB0249584HMDB0341327HMDB0000623HMDB0038883HMDB0302397HMDB0014900HMDB0249535HMDB0002656HMDB0005998HMDB0032022HMDB0038542HMDB0060819HMDB0000570HMDB0275647HMDB0269626HMDB0062207HMDB0241492HMDB0304628HMDB0015418HMDB0040654HMDB0279689HMDB0256971HMDB0034547HMDB0036656HMDB0039436HMDB0002496HMDB0302216HMDB0000872HMDB0243538HMDB0033728HMDB0251803HMDB0289010HMDB0304803HMDB0003871HMDB0036304HMDB0000686HMDB0277304HMDB0035287HMDB0038388HMDB0013157HMDB0029767HMDB0035142HMDB0030608HMDB0034693HMDB0304284HMDB0247617HMDB0062742HMDB0266114HMDB0061047HMDB0010397HMDB0301791HMDB0028953HMDB0266684HMDB0034086HMDB0010387HMDB0000626HMDB0010379HMDB0249587HMDB0004670HMDB0030053HMDB0029429HMDB0257197HMDB0011474HMDB0242435HMDB0260875HMDB0011487HMDB0010386HMDB0251084HMDB0242415HMDB0036440HMDB0250454HMDB0010393HMDB0000478HMDB0244296HMDB0012458HMDB0060526HMDB0061706HMDB0039883HMDB0003533HMDB0252992HMDB0010395HMDB0012515HMDB0062385HMDB0247018HMDB0012516HMDB0258186HMDB0002384HMDB0282074HMDB0340931HMDB0002183HMDB0257308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