MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/m_MTBLS15553_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/m_MTBLS15553_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/a_MTBLS15553_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/a_MTBLS15553_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/s_MTBLS15553.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH2-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH4-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con1-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH1-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH5-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH3-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con2-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH2-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con1-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con3-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH3-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con4-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH1-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con5-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con6-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con5-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/QC1-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con6-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con4-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con3-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/Con2-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/QC4-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/QC1-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH4-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH6-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH5-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/QC3-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/QC2-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/QC4-neg.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/CrH6-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/QC2-pos.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553/FILES/RAW_FILES/QC3-neg.rawprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15553Metabolites were annotated by matching accurate mass, retention time, and MS/MS fragmentation information against mzCloud, mzVault, and MassList databases. Positive and negative ion mode datasets were processed separately.MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseChromatographic separation was performed using a Vanquish UHPLC system equipped with a Hypersil GOLD C18 column (100 x 2.1 mm, 1.9 um; Thermo Fisher Scientific). The column temperature was maintained at 40 degrees C and the flow rate was 0.2 mL/min. For positive ion mode, mobile phase A was 0.1% formic acid in water and mobile phase B was methanol. For negative ion mode, mobile phase A was 5 mmol/L ammonium acetate in water adjusted to pH 9.0 and mobile phase B was methanol.Rumen-fluid metabolomic profiling of periparturient dairy cows supplemented with high-dose chromium propionate before calving.North West Agriculture and Forestry Universityyuzhen Suirumen fluidmass spectrometry assayApproximately 100 mg of thawed and well-mixed rumen-fluid sample was extracted with 500 uL of pre-chilled 80% methanol. Samples were homogenized on ice, vortexed thoroughly, incubated on ice for 5 min, and centrifuged at 15,000 x g for 20 min at 4 degrees C. The supernatant was diluted with LC-MS-grade water to a final methanol concentration of 53%, centrifuged again under the same conditions, and used for LC-MS/MS analysis. Quality control samples were prepared by pooling equal aliquots of all sample extracts.Bos taurushttps://www.ebi.ac.uk/metabolights/MTBLS15553yuzhen Sui. North West Agriculture and Forestry University. sui1632020@163.com.Raw LC-MS/MS data were processed using Compound Discoverer software version 3.3. Data processing included retention time correction, peak detection, peak alignment, peak area integration, and relative quantification. Peak intensities were normalized using the total peak area method. Metabolic features with a coefficient of variation greater than 30% in quality control samples were excluded from downstream analysis.Treatmentsui1632020@163.comRumen-fluid samples were collected from Holstein dairy cows on the day of calving using an oral stomach tube. The initial portion of rumen fluid was discarded to minimize saliva contamination, and representative rumen-fluid samples were transferred into sterile tubes. Samples were immediately frozen in liquid nitrogen and stored at -80 degrees C until untargeted LC-MS/MS metabolomic analysis. The analyzed samples were obtained from cows in the control and high-dose chromium propionate supplementation groups.MetabolomicsOrbitrap Exploris 120 mass spectrometer, Thermo Fisher ScientificMetabolomicsLC-MS/MSuntargeted metabolomicsuntargeted analysisVanquish UHPLC system, Thermo Fisher Scientificrumen fluidBos tauruspooled sampleOrbitrap Exploris 120 mass spectrometer, Thermo Fisher ScientificMetabolomicsLC-MS/MSuntargeted metabolomicsuntargeted analysisVanquish UHPLC system, Thermo Fisher Scientificrumen fluidBos tauruspooled sampleMass spectrometric detection was performed using an Orbitrap Exploris 120 high-resolution mass spectrometer equipped with an electrospray ionization source. Samples were analyzed separately in positive and negative ion modes. The spray voltage was set to 3.5 kV, and full-scan MS data were acquired over an m/z range of 100-1,500. MS/MS spectra were acquired in data-dependent acquisition mode for metabolite structural annotation.Corticosterone6-methyl-2-(4-methylphenyl)pyrimidin-4-yl 4-methylbenzene-1-sulfonate2,4-dichlorobenzaldehyde 1-methyl-1-(6-methylpyridazin-3-yl)hydrazoneDL-PanthenolMonolaurin2-(benzylamino)-6-methyl-5-(2-methyl-1,3-thiazol-4-yl)nicotinonitrile13(S)-HOTrEN-AcetyldopamineU-47700-d6Imidazolelactic acidWLHLysopa 16:02-[(3S)-1-(2-Thienylmethyl)-3-pyrrolidinyl]-1,3-benzoxazole8-Aminooctanoic acidMethyl nicotinateWLK1-(3,4-dimethoxyphenyl)ethan-1-one oximeIsobutyryl carnitineLPC 16:0-SN12-Arachidonoyl glycerol1-[(3,5-dimethylisoxazol-4-yl)sulfonyl]piperidine4-[4-(1-phenyl-1H-1,2,4-triazol-5-yl)-1,3-thiazol-2-yl]pyridine3-(cyclopropylmethyl)-2-mercaptoquinazolin-4(3H)-oneL-TyrosinemethylesterMonensinD-SphingosineApocynin2,3-Dinor-TXB24-methylphenyl 1-ethyl-3-methyl-1H-pyrazole-5-carbothioateAlloxanN-[1-(4-methoxy-2-oxo-2H-pyran-6-yl)-2-methylbutyl]acetamideMethyl indole-3-acetate6-Methoxy-2-naphthoic acidN-MethylisoleucineNeopterin5-(benzyloxy)-2-(hydroxymethyl)-1,4-dihydropyridin-4-one4-HydroxybenzaldehydeHPK7-(2-aminophenyl)heptanoic acidL-lysinePilocarpineN6-Me-dAJasmone20-Carboxy-Leukotriene B4N6-Acetyl-L-lysine2'-O-Methylguanosine3-(propan-2-yl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dione2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acidGlutathione2-oxa-4-azatetracyclo[6.3.1.1~6,10~.0~1,5~]tridecan-3-oneFMH6-MethylquinolineD-(+)-Maltose(+/-)12(13)-DiHOMEMaltopentaoseFexofenadine6,8-dihydroxy-3-(10-hydroxyundecyl)-3,4-dihydro-1H-2-benzopyran-1-one1-(4-hydroxyphenyl)propane-1,2-diolLoxoprofenPI-Cer 36:3;3OIsophorone4-Methyl-5-thiazoleethanolOleamideN6-Methyladenine1,4-Dihydro-1-Methyl-4-Oxo-3-PyridinecarboxamideLidocaine N-oxidePantothenic acid10-Undecenoic acidVindolinePE 14:0_14:0PE 14:0_14:14-(cyclohexylmethyl)-6-(2-thienyl)-2,3-dihydropyridazin-3-one hydrateViramune3-hydroxy-2-octylpentanedioic acidXanthurenic acidIrganox 259L-OrnithineD-Glucosamine 6-phosphate5,6-dimethyl-4-oxo-4H-pyran-2-carboxylic acid5-chloro-6-(trifluoromethyl)-1,3-dihydro-2H-benzimidazole-2-thioneN-Formylkynurenine2-[1-(5-chlorobenzo[b]furan-2-yl)ethylidene]hydrazine-1-carbothioamideOxaceprolDKK(2S)-2-(2-hydroxypropan-2-yl)-2H,3H,7H-furo[3,2-g]chromen-7-one4-oxododecanedioic acid2-{[4-(tert-butyl)-4H-1,2,4-triazol-3-yl]thio}-3-nitropyridine3-(3,4,5-trimethoxyphenyl)propanoic acid4-Methoxybenzaldehyde1-Phenyl-3-methyl-5-pyrazolone(12Z)-9,10,11-trihydroxyoctadec-12-enoic acidUMP3-hydroxy-3-(2-pyridylmethyl)indolin-2-oneRetrorsine2-Phenylglycine1-allyl-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one16,16-Dimethyl prostaglandin A13-(2-Naphthyl)-D-AlanineDLKHomogentisic AcidPE 15:0_15:0IndoleN-(5-Aminopentyl)acetamideNorsufentanilDL-Arginine10-Nitrolinoleate4-(2,3-dihydro-1,4-benzodioxin-6-yl)butanoic acidL-CarnitineFQHo-CresolAdenosine18-β-Glycyrrhetinic acidGly-Tyr-AlaPyridoxine O-Glucoside1-Methyl-2-[(3S)-1-(2-methylbenzyl)-3-pyrrolidinyl]-1H-benzimidazole1,3,5-Trimethylpyrazole2-Hydroxycinnamic acidDL-Norvaline4-morpholinobenzoic acidAla-trp2-(14,15-Epoxyeicosatrienoyl) glycerolD-Erythrose 4-phosphate2-[5-(2-hydroxypropyl)oxolan-2-yl]propanoic acidCitral4-Hydroxyretinoic AcidL-PhenylalaninePE 16:0_16:05-MethylcytosinePE 16:0_16:1Ala-LeuPropionyl-L-carnitineIsoproterenolOleanolic acidEcgonine(+)-EvodiaminePC 16:0_17:2Thromoboxane B1gamma-Glutamylleucinegamma-GlutamylmethioninePI-Cer 37:3;3OMethyl EudesMate2-ethyl-2-(3-methoxyphenyl)cyclohexanone oxime7-Aminoclonazepam-d41,1-Dimethyl-2-oxopropyl N-[2-(2-pyridyl)ethyl]carbamate4-[(4-phenethyl-1,4-diazepan-1-yl)sulfonyl]-2,1,3-benzoxadiazole11-dehydro Thromboxane B25-acetyl-2,6-dimethyl-1,2,3,4-tetrahydropyridin-4-one3-(2-naphthyl)-5-(trifluoromethyl)-1H-pyrazoleDPKDL-Tryptophancis-7-Hexadecenoic AcidDebromohymenialdisineMGDG O-8:0_22:4Guanine2-NaphtholNAOrn 14:0/16:0L-Threonic acid-1,4-lactoneDGDG O-8:0_2:0Epinastine4-Methoxycinnamic Acid3-benzyl-4-hydroxy-5-(4-hydroxyphenyl)-2,5-dihydrofuran-2-oneethyl 3-oxo-3-(1H-pyrazol-5-ylamino)propanoateLysopg 18:11,4-dihydroxyheptadec-16-en-2-yl acetate7-Methylguanine6-Pentyl-2H-pyran-2-one6-(3-hydroxybutan-2-yl)-5-(hydroxymethyl)-4-methoxy-2H-pyran-2-one1-MethyladenineLevalbuterol(3beta,9xi)-3-(beta-D-Glucopyranosyloxy)-14-hydroxycard-20(22)-enolide3-(4-hydroxy-3-methoxyphenyl)propanoic acid9-AminoacridineProstaglandin K21-(7-methoxy-2-oxo-2H-chromen-8-yl)-3-methyl-2-oxobutyl acetateAdenosine 3'5'-cyclic monophosphatePipecolic acidSPKIndole-3-acrylic acid4-(4-methoxyphenyl)-2-(2-thienyl)pyrimidineMethyl cinnamate5,5-dimethyl-3-morpholinocyclohex-2-en-1-one15-epi Prostaglandin A12-morpholinophenyl 2-thiophenecarboxylateAdrenosterone4-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylamino)-4-oxobutanoic acid1-Palmitoyl-Sn-Glycero-3-PhosphocholineSQHAsp-PheBisphenol M2-methyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-4-oneHydroquinone(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(2-phenylethoxy)oxane-3,4,5-triol1-adamantyl(1,4-thiazinan-4-yl)methanone5(S)-HpEPE2-{[(4,5-dimethoxy-2-nitrophenethyl)imino]methyl}phenolN-P-Coumaroyl SpermidineMonobutyl phthalateL-Glutamate2'-Deoxyadenosine-5'-monophosphateEcgonine methyl esterGuanosine-3',5'-cyclic monophosphateN3,N4-Dimethyl-L-argininePE 17:0_17:1J1471H-indene-3-carboxamide1,4-dihydroxy-1,4-dimethyl-7-(propan-2-ylidene)-decahydroazulen-6-oneQNKLPC 22:6-SN1L-AdrenalineN-(2-morpholinophenyl)-2-furamidecis-Aconitic acid3-[4-methyl-1-(2-methylpropanoyl)-3-oxocyclohexyl]butanoic acid3-(dimethylamino)-1-[4-(phenylsulfonyl)phenyl]prop-2-en-1-oneThymine16α-HydroxydehydroepiandrosteronePhysostigmine4-styrylpyridine1-Methyladenosine(4E)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one4-HydroxyisoleucineMaltolSinomenine3,4,10,11-tetramethoxy-7,8,12b,13-tetrahydro-5H-6-azatetraphene3-(2-methylpropyl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dioneethyl 1-(3-nitro-2-thienyl)piperidine-4-carboxylateCoenzyme Q2Gamma-Glu-Leu4-[4-(aminocarbonyl)piperidino]-4-oxobut-2-enoic acid3-Hydroxy-3-methylbutanoic acidN-Acetylsphingosineo-Toluic AcidL-ThreoninePC 17:0_17:1Testosterone undecanoateNervonic ceramideAndrographolide3-(5-phenyl-1,3-oxazol-2-yl)-4-(trifluoromethyl)pyridineLSD-d3alpha-Ketoglutaric acid5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-oneTrigonelline5,8-dihydroxy-10-methyl-5,8,9,10-tetrahydro-2H-oxecin-2-one5-Hydroxyindole-3-acetic acid(1E)-5-hydroxy-1,7-diphenylhept-1-en-3-oneN6-Succinyl Adenosinediethyl 2-[(4-benzhydrylpiperidino)methylidene]malonateL-5-Hydroxytryptophan3-MethoxyflavoneR-1 Methanandamide phosphate6β-Oxycodol N-oxideCryptotanshinoneStearoyl Ethanolamide2,3-dihydroxypropyl 12-methyltridecanoate1-(3-ethyl-2,4-dihydroxy-6-methoxyphenyl)butan-1-oneDGDG O-8:0_22:1CystineIp7GOctopamine6-methoxy-4-(trifluoromethyl)nicotinamideN-(2-hydroxyphenyl)acetamide2-(3,4-dihydroxyphenyl)acetamideDopamineThymidine 3,5-cyclic monophosphateN-Methyldioctylamine3-Hydroxylidocaine2-Methylpentanedioic acidPsoralidinDibutyl sebacateethyl 3-amino-4-(methylamino)benzoate6-methyl-4-(morpholinomethyl)-2H-chromen-2-oneUracilEicosapentaenoic acid2-{2-[(1-methyl-1H-pyrazol-5-yl)amino]-2-oxoethoxy}acetic acidTryptamineCuminaldehyde(2,6-dimethylmorpholino)(1-methyl-5-nitro-1H-pyrazol-4-yl)methanoneL-KynurenineCreatineN-Acetylcytidine3-ethoxy-5-(trifluoromethyl)pyridine-2-carboximidamide4-oxo-5-phenylpentanoic acidOctopine16-Heptadecyne-1,2,4-triolCytosine2-{[methyl(2,3,4,5,6-pentahydroxyhexyl)amino]methylidene}malononitrile3-SuccinoylpyridineCer 18:1;3O/24:0;(2OH)Prostaglandin E2-1-glyceryl esterN-acetyl-L-ornithinemethyl 2-[(2-acetyl-3-oxo-1-butenyl)amino]acetate4-methyl-6-phenyl-5,6-dihydro-2H-pyran-2-oneN1-piperidinocarbonyl-4-methylbenzene-1-sulfonamideethyl 4-(6-bromo-2-methyl-4-oxo-3,4-dihydroquinazolin-3-yl)benzoate3-ethyl-4-hydroxy-1-methyl-1,2-dihydroquinolin-2-one3-Hydroxypicolinic acid2,6-Dihydroxypurine2-cyano-2-(2,3-dihydro-1H-inden-1-yliden)acetamideHomovanillic acidTriptolideNicotinuric AcidSL 11:1;O/16:1;O2-(acetyloxy)-3-amino-1-[1,2-di(acetyloxy)ethyl]-3-oxopropyl acetateL-Glutamic acidCatechinTG 18:2_18:2_18:24-fluoro-N-[4-(4-methylpiperazino)phenyl]benzenesulfonamideKKKPE 31:1Ginsenoside Rb14-oxo-4-[(1-phenylethyl)amino]but-2-enoic acidD-(-)-Salicincis-ResveratrolErgosta-5,7,9(11),22-Tetraen-3-beta-Ol2-methoxy-5-(1H-1,2,4-triazol-5-yl)-4-(trifluoromethyl)pyridineα-Linolenoyl ethanolamide(11E,15Z)-9,10,13-trihydroxyoctadeca-11,15-dienoic acidTG 18:1_18:2_18:2L-(+)-CitrullineDesthiobiotin1-(4-bromophenyl)-2-phenylethan-1-oneD-PanthenolL-beta-Imidazolelactic acidVitamin AHistidineSodium cholateDelta-TridecalactoneTyramineCYM-5442(6E)-7-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)hept-6-en-1-oneKMHSphingosine (d18:1)NAOrn 16:0/16:0SedanolideGly-Val5,6-dimethoxy-2-(2-methoxyphenyl)-4H-chromen-4-one(3-Methoxy-4-hydroxyphenyl)ethylene glycol sulfateN-(9-oxodecyl)acetamideLPE 17:03-(3-Methoxyphenyl)propionic acidAzetidine-2-carboxylic acidCyclohexylsulfamateEthylmalonatePC 34:2KNK7-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-2H-chromen-2-oneThr-Leu25-hydroxycholecalciferolGlycerol-3-phosphate5-[(10Z)-14-(3,5-dihydroxyphenyl)tetradec-10-en-1-yl]benzene-1,3-diolCholine GlycerophosphateLPC O-19:0LuteolinCystamine4-(tert-butyl)phenyl 3,5-dimethylisoxazole-4-carboxylateAll-Trans-13,14-Dihydroretinolgamma-Glutamylglutamine5-Aminovaleric acidXanthineDiflorasoneD-GlucosamineCholineTG 16:0_16:0_18:2PE 17:1_17:1KPHN-ButylbenzenesulfonamideN,N-dimethyl-9H-purin-6-amine(5E)-7-methylidene-10-oxo-4-(propan-2-yl)undec-5-enoic acidL-HydroxyprolineNicotinic acidILKL-Alanyl-L-proline2-Amino-6-methylmercaptopurine4-[(4-chlorophenyl)thio]-1-methyl-1H-pyrazolo[3,4-d]pyrimidine3,4-dihydro-2H,6H-[1,3]thiazino[2,3-b]quinazolin-6-one3'-O-MethyluridineSPB 19:0;2OCarvone7-MethylxanthineKQHIMH2-hexyl-5-(4-nonylphenyl)pyrimidine3-MethylindoleIndole-3-pyruvic acid2-Amino-1,3-octadecanediolGlycyl-L-leucineOxymatrineABL 1272,3-Dinor-11β-prostaglandin F2α2'-DeoxyadenosineLipoic acidMethyl alpha-D-glucopyranosideINKThromboxane B24-oxo-4,5,6,7-tetrahydrobenzo[b]furan-3-carboxylic acid3-Oxo-7alpha,12alpha-hydroxy-5beta-cholanoic acid5-Methyl-2'-deoxycytidineDihydrothymineKanosamine2'-O-MethylcytidineH-Gly-Pro-OH2-(2-hydroxy-3-methylbutanamido)-4-methylpentanoic acidD-(+)-Proline5-Methoxyindole-3-Carbaldehyde3-Acetoxyurs-12-en-23-oic acid4-(3,4-dimethoxyphenyl)-3-methyl-1H-pyrazol-5-amine5-Methyl-dl-tryptophan5-(hydroxymethyl)-4-methoxy-2,5-dihydrofuran-2-oneacetoacetateo-VeratraldehydeD-2-Aminoadipic acidEstroneIsoeugenyl acetate5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one(+/-)-Equol1-morpholino-3-(4-nitrophenoxy)propan-2-olPE 15:0_16:1GLKRiboflavin1,3-bis(4-methoxybenzyl)-2-phenylhexahydropyrimidineL-(-)-alpha-Amino-epsilon-Caprolactam2-Methoxyresorcinol8-Isoprostaglandin F1αEicosapentaenoic acid ethyl esterFolic acidCDP4-(anilinomethylidene)-3-methyl-4,5-dihydroisoxazol-5-oneLysope 14:0N-DesmethyltramadolD-(+)-CamphorFeruloyl PutrescineGMK3-amino-4-(propylamino)cyclobut-3-ene-1,2-dione(+)-ar-TurmeroneAll trans-RetinalFlunitrazepam-d32-ethyl-1H-perimidinePE O-16:1_18:26-methoxy-2,3,4,9-tetrahydro-1H-beta-carbolin-1-oneUrsolic acidTributyl citrateN4-phenethylmorpholine-4-carbothioamide2-phenyl-4H-furo[2,3-h]chromen-4-one2-deoxyglucose-6-phosphateL-AsparagineParacetamolN-{5-[(dimethylamino)sulfonyl]-2-methylphenyl}cyclohexanecarboxamideVLHGuanosine monophosphateVLK2-[(3S)-1-(2-Chlorobenzyl)-3-pyrrolidinyl]-5-methyl-1,3,4-oxadiazoleEstriol2'-O-Methyladenosine2-[(3S)-1-Benzyl-3-pyrrolidinyl]-1,3-benzothiazoleN'-[4-(tert-butyl)phenyl]-N-cyclohexyl-N-methylureaH-Trp-NH2Cytidine 5'-monophosphate (hydrate)5-HydroxytryptopholGlyciteingamma-Nonanolactone11-OxoetiocholanoloneIsoferulic acidN-benzyl-2-(6-methoxy-2-naphthyl)propanamideO-74603-methyl-4-nitrobenzene-1-carbohydrazide5-amino-2-(dimethylamino)benzoic acidOctyl hydrogen phthalate2,4-dihydroxyheptadec-16-en-1-yl acetateELK13,14-dihydro-15-keto Prostaglandin A24-Acetamidobutyric AcidN1-(2-pyridyl)-2-(3,5-difluorophenyl)acetamideDL-LysineLysope 16:01,7-bis(4-hydroxyphenyl)-5-methoxyheptan-3-one违-L-Glutamyl-L-glutamic acid7-(3,4-dihydroxyphenyl)-5-hydroxy-1-(4-hydroxyphenyl)heptan-3-oneTriacanthine3-phenyl-2-(3-pyridyl)-1,3-thiazolan-4-oneBoc-beta-cyano-L-alanineDG O-22:4_14:03,4-dihydroxy-4-(4-methoxyphenyl)-1,2,3,4-tetrahydroquinolin-2-oneLPC 20:4-SN1AlanyltyrosinePalmitoyl sphingomyelinFenvalerateFumonisin B1Fumonisin B2TKK1-Methylguanine2-hydroxy-3,6-diphenylcyclohexyl acetate2,4-dichloro-N-{2-[(2-furylmethyl)amino]-1-methyl-2-oxoethyl}benzamide1-{4-[2-nitro-4-(trifluoromethyl)phenyl]piperazino}ethan-1-one5-Aminosalicylic AcidHydroxyprogesterone caproate7-(1-pyrrolidinyl)pyrimido[4,5-d]pyrimidin-4-amineProlineN1-(5-methylisoxazol-3-yl)-2-morpholinoacetamide1-(3-phenylpropanoyl)-4-piperidinecarboxylic acid2-{[5-(trifluoromethyl)-2-pyridyl]thio}acetic acid(2E)-6-hydroxy-2-methyl-6-(4-methylphenyl)hept-2-enoic acid1,2-dihydroxyheptadec-16-yn-4-yl acetateLPC 18:0-SN1Glycoursodeoxycholic acidIndole-3-acetic acid3-methyl-5-oxo-5-(4-toluidino)pentanoic acid2-(2,6-dimethoxyphenyl)-5,6-dimethoxy-4H-chromen-4-one2-[(3S)-1-(4-Fluorobenzyl)-3-pyrrolidinyl]-5-methyl-1H-benzimidazoleL-Methionine Methyl EsterN1-isopropyl-2-(1H-2-pyrrolylcarbonyl)-1-hydrazinecarboxamideL-Tyrosine(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(propan-2-yloxy)oxane-3,4,5-triolAflatoxin B1AdipamideEPHEPK3-hydroxy-3-methylpentanedioic acid4-methoxy-6-(prop-2-en-1-yl)-2H-1,3-benzodioxoleSitagliptin5-Phenylvaleric Acidgamma-GlutamyltyrosinePC 17:1_17:14-hydroxy-3-(3-methylbut-2-en-1-yl)benzoic acidN-(5-acetamidopentyl)acetamide2-Arachidonyl Glycerol ethermethyl 3,4,5-trihydroxycyclohex-1-ene-1-carboxylateSpermidineEQHFolinic acidAflatoxin M14-phenoxyphenyl 4-hydroxypiperidine-1-carboxylateTG 16:0_18:2_18:2Avocadyne 1-acetateUrocanic acidAlbendazole sulfoneN1-(2-piperidinophenyl)-3,4,5-trimethoxybenzamidePhenyl[(3S)-3-(5-propyl-1,3,4-oxadiazol-2-yl)-1-pyrrolidinyl]methanoneMethylhippuric acidp-Mentha-1,3,8-trieneMetanephrine3-amino-2-phenyl-2H-pyrazolo[4,3-c]pyridine-4,6-diolObscurolide A1PE 16:0_17:1PE 16:0_17:2Pyridoxal 5'-phosphate5-(tert-butyl)-2-methyl-N-(4-nitrophenyl)-3-furamidePiperine3,5-di(2-furylmethylidene)tetrahydro-2H-pyran-4-one2-acetamido-3-(4-methoxyphenyl)propanoic acidAcetophenoneRitalinic aciddimethyl 2-(3-nitro-2-pyridyl)malonateDocosahexaenoic AcidCreatinineAcetyl-L-carnitineCer 17:0;2O/16:0PyridoxineRMH3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-oneRMKSulforidazinetrans-3-Indoleacrylic acidGlycolithocholic acid2-Amino-1,3,4-octadecanetrioltetranor-12(R)-HETELinoleoyl ethanolamideTiglic acid9-Oxo-10(E),12(E)-octadecadienoic acidRNHBetaineN-MethylhydantoinAL 8810 Methyl ester6-Acetylmorphine4-{3-[(3,4-dihydroxyphenyl)methyl]-2-methylbutyl}benzene-1,2-diolL-Leucyl-L-AlanineEnrofloxacinCytidinePC 18:1_18:1Indole-3-lactic acidClinafloxacinIsoquinoline2-(4-aminophenoxy)isophthalonitrileoctadec-9-ynoic acidP-Aminohippuric AcidANHANKProstaglandin F2α-1-glyceryl esterDithranolCer 18:0;2O/16:07-methyl-3-nitroimidazo[1,2-a]pyridineRPKPLHPLK10-Hydroxydecanoic acidN-[4-(aminosulfonyl)phenyl]-2-chloro-6-fluorobenzamide4-Methylvaleric AcidDeoxycorticosterone 21-glucoside3-hydroxy-1,5-diphenylpentan-1-one2-Thio-acetyl MAGECadaverine1-(3-methoxy-2-nitrostyryl)pyrrolidine4-acetyl-4-(ethoxycarbonyl)heptanedioic acid7-Ketolithocholic acidDL-2-(acetylamino)-3-phenylpropanoic acidCer 18:1;3O/23:0;(2OH)RQH5'-Deoxy-5'-(Methylthio)AdenosineVitamin E Acetate2-[(3S)-1-Cyclobutyl-3-pyrrolidinyl]-5-fluoro-1H-benzimidazole6-(4-phenylpiperazino)hexanoic acid hydrochloride1-(4-methoxyphenyl)propane-1,2-dioldUMPAPK3-(3,4-dihydroxyphenyl)propanoic acidProlylleucineProthionamide5-(6-hydroxy-6-methyloctyl)-2,5-dihydrofuran-2-one4-(3-methoxy-5,6-dihydrobenzo[c]acridin-7-yl)morpholineethyl 5-methoxy-2-methyl-1-phenyl-1H-indole-3-carboxylate4-Guanidinobutyric acid5-HydroxytryptophanKynurenic acid3-Indoleacrylic acidMethylmalonateMethyl 3-indolyacetateMethionineNKKIsopropyl myristate2'-DeoxycytidineStyrene4-oxo-4-(5,6,7,8-tetrahydronaphthalen-1-ylamino)but-2-enoic acidCarbadox2,6-Di-tert-butyl-1,4-benzoquinonePPK11-Deoxy prostaglandin F1α5-[(1-benzothiophen-3-ylmethyl)sulfanyl]-1-methyl-4-nitro-1H-imidazoleL-Glutathione oxidized3-MethoxytyramineL-Norleucine1-StearoylglycerolNAOrn 15:0/16:03-Methylcrotonylglycine4-ButylresorcinolDihydromethysticinN-allyl-2-(2-methyl-1-benzofuran-3-yl)acetamideSalsolinolNitrofurantoinSerotoninDihydrozeatinKojic acidN-Stearoyl taurinetrans-4-Phenyl-4-piperidinocyclohexanolDL-m-TyrosineFerulic acid2-(Formylamino)Benzoic Acid3-{[(3S)-3-(1,3-Benzothiazol-2-yl)-1-pyrrolidinyl]methyl}benzonitrileLeucylprolineAKB48 N-(4-fluorobenzyl) analogethyl 2,3-dioxo-1,2,3,4-tetrahydroquinoline-4-carboxylateKinetin 9-ribosideGamma-Aminobutyric acid2-Hydroxyacetophenone8-HydroxyquinolinedUTPMaltotetraoseNNK2-(cyclopropylcarbonyl)-3-(methylthio)-3-morpholinoacrylonitrileHarminePhytosphingosineArachidonoyl amide2-Hydroxyphenylalanine6-amino-1-(2-methylphenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dioneCortodoxone2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methyl-4H-chromen-4-oneFisetinLysoPC 10:0HomoarginineErgocalciferolCoumarin7-(2-hydroxypropan-2-yl)-1,4a-dimethyl-decahydronaphthalen-1-olSpermineStanozololHypoxanthine1-(2-furyl)pentane-1,4-dione2'-O-Methyl-5-methylcytidinePalmitoyl ethanolamide2-Phenylpropionic acidCer 18:0;3O/24:0;(2OH)D-glutamine4-[2-(2-oxo-1-imidazolidinyl)ethyl]-1lambda~6~,4-thiazinane-1,1-dione3-Acetyl-11-keto-β-boswellic acidN-Acetyl-DL-phenylalanine15-OxoEDEN-[2-(1,5-dimethyl-4-nitro-1H-pyrazol-3-yl)vinyl]-N,N-dimethylamine2-[(3S)-1-(2-Methylbenzyl)-3-pyrrolidinyl]-1,3-benzothiazoleN8-AcetylspermidineN1-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamideN6,N6,N6-Trimethyl-L-lysine4-(3-methoxyphenyl)-4-methyl-2,6-dioxopiperidine-3,5-dicarbonitrile5-HydroxyindoleN1,N1-diethyl-4-[2-(4-bromophenyl)diaz-1-enyl]anilinePalmitoleic AcidAdenine(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acidO-Arachidonoyl ethanolamineD-Ala-D-AlaGlu-Val-PheGly-Phe3-(2-chlorophenyl)-3-(2,4-difluoroanilino)acrylonitrileD-ProlineN1-(1H-indol-4-yl)cyclohexane-1-carboxamideInosinePurineDl-3-HydroxynorvalineMethylimidazoleacetic acidLNHTetranor-12(S)-HETEArachidonic acidKuromaninisoleucine1,7-bis(4-hydroxyphenyl)heptan-3-oneN-AcetylmethioninePhenylpropiolic acid(2R)-2-[(2R,5S)-5-[(2S)-2-hydroxybutyl]oxolan-2-yl]propanoic acidCaffeine3,3,5-trimethyl-3H,11H-pyrano[3,2-a]carbazole2-(cyclopropylcarbonyl)-3-(4-fluoroanilino)acrylonitrile2-(3,5-dimethyl-1H-pyrazol-4-yl)-5-methoxybenzoic acid4-methoxy-9-(2-methylbut-3-en-2-yl)-7H-furo[3,2-g]chromen-7-one4-Hydroxybenzoic acid5-trans prostaglandin F2βMaltotrioseValproic acidAbametapir2-piperidinobenzoic acid4-Phenyl-3-buten-2-one3-Methoxy prostaglandin F1α3-methoxy-2-phenyl-4H-furo[2,3-h]chromen-4-oneMethyldopaN-AcetylhistamineNicotinamide2,4-DimethylbenzaldehydeMethyl dihydrojasmonate3-Methyl-2-oxobutanoic acid13-HPODEMaslinic acid4-Methyl-2-Oxopentanoic AcidN-[2-(4-methoxyphenoxy)ethyl]-2-furamide6-HydroxymelatoninN-(4-butyl-2-methylphenyl)-N'-[4-(4-methylpiperazino)phenyl]ureaOleoyl ethanolamideApigenin6,6-dimethyl-4-piperidino-5,6-dihydro-2H-thiine-2-thionePyroglutamic acid4-methyl-5-oxo-2-pentyl-2,5-dihydrofuran-3-carboxylic acidPyridoxamineL-Pyroglutamic acidBiochanin AN-METHYL (-)EPHEDRINE2-phenylthiomorpholin-3-oneN1-(3-pyridyl)-4-[(dipropylamino)sulfonyl]benzamide3-[(4-hydroxyphenyl)methyl]-octahydropyrrolo[1,2-a]pyrazine-1,4-dioneAcetylcholine5-OxoETECholine bitartrate2-(3,4-dimethoxyphenyl)ethanamineLPC 18:2-SN1Diphenylamine4-(2-methoxyphenyl)-1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperidineD-Fructose 6-phosphateDiosmetin4-(benzoylamino)-3-hydroxybutanoic acid8-(1,2-dihydroxy-3-methylbut-3-en-1-yl)-7-methoxy-2H-chromen-2-oneα-LapachoneTryptophanolNicotinamide N-oxideN,N-DimethylarginineNe-(1-Carboxymethyl)-L-lysine[4-(1H-1,2,4-triazol-1-yl)phenyl]methanolHKKlipoamideDL-StachydrineLinolelaidic Acid (C18:2N6T)(+/-)5(6)-EET EthanolamideT-2 Triol3'-Adenosine monophosphate (3'-AMP)Histamine4-(methylthio)-6-phenyl-2-(3-pyridyl)pyrimidine-5-carbonitrile2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acidcis-gondoic acid(5-L-Glutamyl)-L-Amino AcidPhe-PheMethionine sulfoxideN-α-L-Acetyl-arginineGly-TyrSenecioninePhosphoethanolaminep-Hydroxybenzaldehyde1,3-Dimethyluracil1-(4-benzylpiperazino)-2-(pyridin-2-ylamino)propan-1-one16(R)-HETEEpinephrine(1R,2R)-trans-N-Boc-1,2-cyclohexanediamineN-Acetyl-L-leucine15-Deoxy-δ12,14-prostaglandin J2-2-glycerol esterPC 18:2_18:2NAOrn 16:0/17:02,5-Furandicarboxylic acidN1-AcetylsperminePsoralen2'-DeoxyguanosineDeoxycytidineValylprolineWKKPE O-15:1_16:0N'-{6-[(5-chloro-3-pyridyl)oxy]-3-pyridyl}-N,N-dimethyliminoformamideDaidzeinLPE 16:07α-HydroxytestosteronefalseRumen-fluid metabolomic profiling of periparturient dairy cows supplemented with high-dose chromium propionate before calvingThis study contains untargeted LC-MS/MS metabolomic profiles of rumen-fluid samples collected on the day of calving from Holstein dairy cows in the control and high-dose chromium propionate supplementation groups. Cows received either a basal total mixed ration without supplemental chromium propionate or the same ration supplemented with 20 g chromium propionate per cow per day, providing 8 mg Cr(III) per cow per day, from 21 days before expected calving until parturition. Rumen-fluid samples were collected at calving and analyzed to characterize ruminal metabolic responses associated with prepartum chromium propionate supplementation during the periparturient 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