Taxonomic annotation was performed against the Silva database (v138) using q2-feature-classifier.
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - alternating - hilic"],"chromatography_protocol":["UHPLC-MS/MS Conditions: Metabolites were separated on a Vanquish UHPLC system using an ACQUITY UPLC BEH Amide column (Waters) and analyzed on an Orbitrap Exploris 480 mass spectrometer (Thermo Fisher) in positive/negative DDA modes.
"],"publication":["Prevention of acute graft-versus-host disease via single-dose administration of bioengineered extracellular vesicles."],"submitter_affiliation":["University of Science and Technology of China"],"submitter_name":["Xinye Zhang"],"organism_part":["feces"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["Sample Preparation & QC: Fecal samples were homogenized and extracted with cold methanol/acetonitrile (1:1, v/v), dried, and reconstituted in acetonitrile/water (1:1, v/v); pooled quality control (QC) samples were injected periodically to assess instrument stability.
"],"organism":["Mus musculus"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS15633"],"author":["Cheng Linzhao. University of Science and Technology of China. lzcheng@ustc.edu.cn.","Xinye Zhang. University of Science and Technology of China. jojozhangxy@gmail.com.","Liu Senquan. University of Science and Technology of China. liusenquan1988@ustc.edu.cn."],"data_transformation_protocol":["Raw reads were trimmed using Cutadapt, and subsequent quality filtering, denoising, and chimera removal were executed via the DADA2 plugin within QIIME2 (v2020.11) to generate the amplicon sequence variant (ASV) abundance table.
"],"study_factor":["Treatment"],"submitter_email":["jojozhangxy@gmail.com"],"sample_collection_protocol":["Sample Collection & Storage: BALB/c mice were divided into BM, BM+T, and BM+T+eEVs groups to establish an aGVHD model. On day 14 post-transplantation, colonic fecal samples (~80 mg) were collected, snap-frozen in liquid nitrogen, and stored at -80°C.
"],"omics_type":["Metabolomics"],"study_design":["Thermo Scientific Vanquish UHPLC System","EV","SOCS3","Metabolomics","Mus musculus","Thermo Scientific Orbitrap Exploris 240","untargeted analysis","feces","graft versus host disease"],"curator_keywords":["Thermo Scientific Vanquish UHPLC System","EV","SOCS3","Metabolomics","Mus musculus","Thermo Scientific Orbitrap Exploris 240","untargeted analysis","feces","graft versus host disease"],"mass_spectrometry_protocol":["Data Processing & Statistics: Raw files were processed using XCMS for peak picking and alignment; differential metabolites were identified based on VIP > 1.0 from OPLS-DA and FDR < 0.05
"],"metabolite_name":["Resveratrol 3-O-D-glucuronide","Ile-Thr","L-Tyrosine tert-butyl ester","Staurosporine","Cholest-5-ene-3b,20,22R-triol","N-[(4-Nitrophenyl)methyl]benzamide","(Z,E)-Tetradeca-9,12-dienol","Ser-Thr","(2S)-2,6-diaminohexanamide","Methyl linolenate","Mephosfolan","D-erythro-N-stearoylsphingosine","Phe-Ile","Populin","N-Oxyclozapine","Strevertene A","(1.beta.,3.beta.,8.xi.,9.xi.,14.xi.)-3-((6-Deoxy-.alpha.-L-mannopyranosyl)oxy)spirosta-5,25(27)-dien-1-yl 6-deoxy-2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-galactopyranoside","Cycloate","Asn-Arg-Lys","Val-Met","Pantothenol","Oxeladin","Steganacin","Normorphine","Timolol","Panobinostat","Montanin D","Sethoxydim","Azepane-1-carboxylic acid (4-chlorophenyl)amide","Bifenazate","(4r)-4-((3r,5s,7r,9s,10s,13r,14s,15r,17r)-3,7,15-trihydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid","Dye X-5380-16 Cation","3.beta.-Tetrahydrocortisol, 3,21-diacetate","N-Hexanoylsphingosine","1-(1Z-Octadecenyl)-sn-glycero-3-phosphocholine","Imazapyr","Glu-Thr-Arg","Thr-Val-Arg","0","Gly-Gly-Leu","4''-trans-Hydroxycilostazol","D-Psicose","Hyocholic acid","4-Methoxypyridine-2-carboxamide","D-Glucosaminic acid","Trp-Gly-Trp","9Z,11E,13E-Octadecatrienoic acid","Acridine Orange","2-Acetamido-3-(4-hydroxy-3-methoxyphenyl)propanoic acid","[(2r,3s,4s,5r,6r)-6-[1,7-bis(4-hydroxyphenyl)-5-oxoheptan-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl (e)-3-(3,4-dimethoxyphenyl)prop-2-enoate","Benzyldimethyltetradecylammonium cation","2-Ethylhexyl diphenyl phosphate","Koninginin D","6-Bromo-4-(piperazin-1-yl)quinazoline","9-Hydroperoxy-10E,12Z,15Z-octadecatrienoic acid","Tyr-Ile","Simeconazole","(3E)-4-(2,4,6-Trimethyl-3-cyclohexen-1-yl)-3-buten-2-one","N-Benzyl(1-naphthyl)methanamine","Cimicifugoside H 2",".alpha.-Guanidinoglutaric acid","Pilocarpine","N-Cyclohexyl-N'-(1-naphthyl)urea","Selfotel","2-(3-Fluorophenyl)benzonitrile","12-Ketodeoxycholic acid","Ile-Met-Lys","Arginine","Bisphenol A diglycidyl ether","Eurycomalactone","N-1-Adamantylquinoline-2-carboxamide","3-Cyano-N-(2,5-diphenylpyrazol-3-yl)benzamide","2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, (2E)-","Asn-Ile-Arg","Racemoramide","Triethyl citrate","3-(3-Fluorobenzyl)piperidine","Pro-Gln","Aminorex","Azocyclotin","Beta-alanine","Leu-Ala-Arg","6-Fluoro-3-(4-piperidinyl)-1H-indole","Tetrabenazine","Roquefortine a","Carbetamide",".beta.-Estradiol 3-benzoate","N,N-Dimethyl-2,2-diphenylethanamine","7-(2-Aminophenyl)heptanoic acid","Hexylglutathione","N6-Methyladenine","Dioscin","Methylergonovine","Ile-Trp-Lys","1-Pyrrolidineheptanoic acid, 2-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-yn-1-yl]-5-oxo-, (2R)-","Pro-Glu","3-(4-Hydroxy-2,2-dimethyl-1-oxo-3,3a-dihydroimidazo[1,2-a]indol-4-yl)-2-(4-oxoquinazolin-3-yl)propanoic acid","Moxonidine","N-(Deshydroxyethyl)dasatinib","Pantothenic acid","3-(6-Amino-9H-purin-9-yl)-1,2-propanediol","2-(Cyclohexylamino)benzoic acid","N-Desethylsunitinib","Yohimbine","Man1F","Prostaglandin E2 serinolamide","6-Benzylaminopurine","(2r,3s,4s,5r,6r)-2-[[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[4-(4-hydroxyphenyl)butan-2-yloxy]oxane-3,4,5-triol","Glutamylphenylalanine","Tetrahydrocortisol 21-acetate","(-)-.alpha.-Kainic acid","Dilinolenin (9c,12c,15c)","Echinocystic acid 3-glucoside","Taprostene (free acid)","Thr-Met","17.alpha.-Ethynylestradiol","Pirimicarb-desamido","Tropicamide","15-Ketoprostaglandin E1","Fucosterol","Metalaxyl","Azelastine",".beta.-Nicotinamide adenine dinucleotide","Diflufenzopyr","Ala-Trp","Monoisobutyl phthalate","Cloquintocet-mexyl","1,2-dioleoyl-sn-glycero-3-phosphatidylcholine","2-(1,3-Benzothiazol-2-ylthio)acetohydrazide","(2-oxo-2,3-dihydro-1h-indol-3-yl)acetic acid","Rucaparib","Val-Asp-Lys","Prostaglandin D1","Prolylalanine","Prostaglandin D3","Dienestrol diacetate","Benzyl alcohol","Tetramethylammonium cation","Rutinose","Linoleoylglycine","3-[(2s,3r,4s,5s,6r)-6-[[(2r,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]oxy-2-methylpyran-4-one","Pyridine","Ala-Ala","Digitoxin","Hexanoyl-L-carnitine","7.alpha.,12.alpha.-Dihydroxycholest-4-en-3-one","1-O-((3.beta.,5.Xi.,9.Xi.)-3-((3-O-.beta.-D-Glucopyranosyl-D-glucopyranosyl)oxy)-28-oxoolean-12-en-28-yl)-.beta.-D-glucopyranose","Asp-Leu-Arg","Chenodeoxycholic acid","Azamethiphos","Emetamine","Leukotriene B4 3-aminopropylamide","Auranticin A","11.beta.-Hydroxyprogesterone","Androsterone glucuronide","Indole","Tepraloxydim","Adaphostin","Arg-Pro","Lovastatin","Met-Val-Lys","Dextromethorphan","Leu-Ile-Arg","Withanoside VI","1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidine","Diazinon","[(4S,6R,6aS,9R,10S)-6,10-Diacetyloxy-6a,9-dihydroxy-3-(methoxymethyl)-6,9-dimethyl-2-oxo-5,7,8,10-tetrahydro-4H-benzo[h][1]benzofuran-4-yl] 2-methylprop-2-enoate","Fumonisin b1","Phe-Val-Lys","Ibutilide","4-(2-Fluorophenyl)-3,4-dihydro-1(2H)-naphthalenone","L-Carnitine","O-t-Butyl-L-threonine methyl ester","5-trans-Prostaglandin F2.alpha.","1H-Indole-1-pentanoic acid, 3-[(4-methoxy-1-naphthalenyl)carbonyl]-","Leu-Asp-Arg","N-[5-[(5-tert-Butyloxazol-2-yl)methylthio]thiazol-2-yl]isonipecotamide","(3.beta.,8.xi.,9.xi.,14.xi.,17Z)-3-((2-O-(6-Deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl)oxy)-16,22-dioxocholesta-5,17-dien-27-yl .beta.-D-glucopyranoside","Aminoalbendazole sulfone","Cyclopentolate","1-Oleoyl-2-palmitoyl-rac-glycerol","Estrone sulfate","Adenosine","N-(4-Methoxyphenyl)-2-(1-piperazinyl)acetamide","Etoposide","Scopolamine .beta.-D-glucuronide","Cytidine, 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-, 2',3'-diacetate","2-Hydroxyestradiol","Philanthotoxin 74","Pro-Ile","Pterostilbene","Rostafuroxin","Nakijiquinone h","Neolinustatin","Oligomycin B","Cyclopropylacetic acid","Oligomycin A","Myristoyl ethanolamide","Lobelanidine","Benazepril","Methyl 3,16-dihydroxy-4,4,8,12,16-pentamethyl-15,17-dioxoandrost-11-ene-14-carboxylate","N-(3-Chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamide","gamma-L-Glutamyl-L-valine","L-Bunolol","Isodeoxyelephantopin","2-Thiophenecarboxamide, N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-","1-O-Hexadecyl-2-O-methyl-sn-glyceryl-3-phosphorylcholine","(1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinolin-3-yl)methanol","Melatonin","2-{2-[2-(Methacryloyloxy)ethoxy]ethoxy}ethyl 2-methylacrylate","5-Methylcytosine","N-Butyryl-L-homoserine lactone","Pro-Tyr-Lys","Sisomicin","Fenpropathrin","Isoproterenol","N-Acetyl-D-galactosamine","Clomipramine","2-Phenylbenzene-1-sulfonamide","Oleyloxyethylphosphorylcholine","D-tryptophan","N-.alpha.-(tert-Butoxycarbonyl)-L-histidine","9-Benzyl-9-azabicyclo[3.3.1]nonan-3-one","1-Pentyl-3-(4-methoxynaphthoyl)indole","Lovatatin","Sphingosine","2-Butenoic acid, 7-(acetyloxy)-3,6,7,8,9,10-hexahydro-6-hydroxy-2-methyl-10-oxo-2H-oxecin-3-yl ester","N-Palmitoyl-D-sphingosine","2-Furanacetic acid, tetrahydro-5-(2-hydroxybutyl)-.alpha.-methyl-, 1-[[5-(1-carboxyethyl)tetrahydro-2-furanyl]methyl]propyl ester","6-(Difluoromethoxy)-3-pyridinamine","Valerylfentanyl","4-Hydroxy-1,5-dimethyl-1,2-dihydropyrimidin-2-one","Ile-Ile","17,20-Dimethylprostaglandin F1.alpha.","1-O-((3.beta.,5.Xi.,9.Xi.,18.Xi.)-3-(.beta.-D-Glucopyranuronosyloxy)-23-hydroxy-28-oxoolean-12-en-28-yl)-.beta.-D-glucopyranose","1-Stearoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine","Naphtho[2,1-b]furan-4,5-diol, dodecahydro-2-(1-hydroxy-1-methyl-2-propen-1-yl)-3a,6,6,9a-tetramethyl-","1-(2-Allylphenoxy)-3-(4-morpholinyl)-2-propanol","2-(Diphenylamino)benzoic acid","6-(Methylthio)guanine","Tetrahydroharman-3-carboxylic acid","1-O-(1,3,25-Trihydroxy-28-oxo-20,24-epoxy-9,19-cyclolanostan-28-yl)hexopyranose","Psychosine","9-Oxo-10E,12Z-octadecadienoic acid","Buprenorphine","Lysine","Acetaminophen","1-Ethyl-N4,N5-dimethyl-1H-imidazole-4,5-dicarboxamide","Sclareolide","Heptaminol","5-Nitroisophthalamide","Cabergoline","1-Oleoyl-2-myristoyl-sn-glycero-3-phosphocholine","Hexobarbital","Didecyl hydrogen phosphate","Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-","6-(2,3-Dihydroxy-3-methylbutoxy)-4-methoxy-5-methyl-2,3-dihydroisoindol-1-one","3-Propyl-1H-pyrazole-5-carboxylic acid","Guanine","Meperidine","Suberoylanilide hydroxamic acid","Trihydroxycholestanoic acid","(-)-Neplanocin A","Nigelline","N,2-Dimethyl-N-phenylbutanamide","Chloramphenicol succinate","(2Z)-((4R,5S,6S)-6-(.beta.-D-Glucopyranosyloxy)-4,5-dihydroxycyclohex-2-en-1-ylidene)acetonitrile","Dehydrocostus lactone","Fructoselysine","Putative analog of trichodina","Thr-Leu-Arg","N-Acetyl-DL-leucine","Ampiroxicam","Iprovalicarb","1-methyladenosine","Xanthosine","(3.beta.,5.Xi.,9.Xi.,18.Xi.,22.beta.)-22-Hydroxy-25-oxoolean-12-en-3-yl 6-deoxy-.alpha.-L-mannopyranosyl-(1->2)-.beta.-D-xylopyranosyl-(1->2)-.beta.-D-glucopyranosiduronic acid","N-.alpha.-Acetyl-L-arginine","Myriocin","2-(Methylamino)-1-(morpholin-4-yl)ethan-1-one","Tebufenpyrad","7-Methylguanine","Norcodeine","Gln-Thr-Lys","Fenamidone","Tris(hydroxymethyl)aminomethane","Terpestacin","1-(4-Nitrophenyl)azepane","N-acetylputrescine","Veratramine","2'-Fucosyllactose","7.alpha.,12.alpha.-Dihydroxy-5.beta.-cholestan-3-one","Ranolazine","1H-Benzimidazole-2-butanoic acid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, ethyl ester","N,N-Dimethylhistidine","1-O-((2.beta.,3.beta.,5.Xi.,9.Xi.,18.Xi.)-3-(.beta.-D-Glucopyranuronosyloxy)-2,23-dihydroxy-28-oxoolean-12-en-28-yl)-.beta.-D-glucopyranose","Lys-Pro","Strophanthidol","(3-Carboxypropyl)trimethylammonium cation","Ala-Pro","1-(Diphenylacetyl)piperazine","N,N-Dimethyldodecylamine N-oxide","Pioglitazone","DL-Ornithine","N-.alpha.-(tert-Butoxycarbonyl)-L-proline","Adrenosterone","Met-Phe","N-Methyl-L-asparagine","DL-isoleucine","Carnitine","9-Allyl-2-phenyl-9H-imidazo[1,2-a]benzimidazole","Pro-Thr","Vulgarin","Creatine, ethyl ester","Sebacic acid bis(N-succinimidyl) ester","Zolpidem","L-Valine, N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-, methyl ester","4-Bromo-2-{[(1-propyl-1H-benzimidazol-2-yl)amino]methyl}phenol","5-(Furan-3-yl)-2a',5'-dihydroxy-8b'-(hydroxymethyl)-7'-methyldodecahydrospiro[furan-3,6'-naphtho[1,8-bc]furan]-2-one","Norethindrone 2,3,4-tri-O-acetyl-.beta.-D-glucuronide methyl ester","2,3,16,20,25-Pentahydroxycucurbita-5-ene-11,22-dione-3-O-glucoside","Trimethylamine N-oxide","Bazedoxifene","N2-Acetyl-N-(2-(4-hydroxyphenyl)ethyl)-.alpha.-glutamine","5-(Galactosylhydroxy)-L-lysine","2-Hydroxy-6-methylpyridine-4-carboxylic acid","[9-[(E)-3-Acetyloxy-4-methylhex-4-en-2-yl]-12-hydroxy-3-(2-hydroxypropan-2-yl)-10-methoxy-6a,12b-dimethyl-8,11-dioxo-1,2,3,4a,5,6,12,12a-octahydropyrano[3,2-a]xanthen-1-yl] acetate","1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine","D-erythro-Sphingosine-1-phosphate","Acetyl coenzyme A","Berberine cation","3-Allyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol","2-[(1-Methyl-1H-tetraazol-5-yl)sulfanyl]-N-(2-phenylethyl)acetamide","9-Benzyl-5-[(furan-2-ylmethyl)amino]-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile","tert-Butyl 4-(2-aminoethyl)-1-piperazinecarboxylate","Lithocholylglycine","(-)-Secoisolariciresinol","Biocytin","Ofloxacin","His-Glu-Arg","(24E)-12,15-Dihydroxy-3-(pentopyranosyloxy)-9,19-cyclolanost-24-en-26-oic acid","Trifluoroperazine","Bisoxireno[4,5:8,9]cyclodeca[1,2-b]furan-4(1aH)-one, 2,2a,6,6a,7a,8,9,9a-octahydro-1a,5,7a-trimethyl-","Goshonoside F5","Arthrobactin","Tebuconazol","Ergocristine","1H-Indazole-3-carboxamide, N-1-naphthalenyl-1-pentyl-","Archangelicin","Epothilone B","Pimecrolimus","Cyclo(prolyltyrosyl)","Mahanimbine","5-Methyl-4-phenyl-o-anisidine","Zinniol","2,2'-(2-Hydroxyethylazanediyl)diacetic acid","(5-benzoyloxy-4,6-dihydroxy-3-methoxycyclohexen-1-yl)methyl benzoate","6-Amino-1-benzyluracil","[4-Anilino-2-(4-fluorophenyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrol-3-yl]acetic acid","4-Fluoro-.alpha.-pyrrolidinobutiophenone","Gly-Ile-Lys","3-(.alpha.-L-Arabinofuranosyloxy)pimara-8(14),15-dien-12-yl 6-deoxy-.beta.-D-galactopyranoside","2-Aminophenol","16-Phenoxyprostaglandin F2.alpha. ethylamide","Eprosartan","N-Arachidonoyl-L-alanine","3-Hydroxymethylmefenamic acid","Linearized pseudacyclin a","Valine conjugated chenodeoxycholic acid","4,4'-Oxydibenzene-1,2-diamine","Verruculogen","Pyridoxal","Trigonelline","7-methyl-3-methylidene-6-(3-oxobutyl)-4,7,8,8a-tetrahydro-3ah-cyclohepta[b]furan-2-one","3H-Benzimidazol-5-yl-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amine","NCGC00161382-01","2-Oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine","(3E)-10b-(2-Methylbut-3-en-2-yl)-3-((5-(2-methylbut-3-en-2-yl)-1H-imidazol-4-yl)methylidene)-6,10b,11,11a-tetrahydro-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione","5-Methoxy-4-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one","Betaine aldehyde cation","o-Tolidine","Danazol","1-Acetamidocyclopentane-1-carboxylic acid","Schizandrol","1-Naphthalenecarboxylic acid, 1,2,4a,5,6,7,8,8a-octahydro-2-(2-hydroxybutyl)-1,3-dimethyl-, [1R-[1.alpha.,2.beta.(R),4a.alpha.,8a.alpha.]]-","(-)-Atropine","Prostaglandin E1 ethanolamide","L-Hydroxyarginine","7-Methylguanosine","28-Hydroxy-28-oxoolean-12-en-3-yl 6-deoxyhexopyranosyl-(1->3)hexopyranosyl-(1->2)hexopyranosiduronic acid","Methanone, [1-(5-hydroxypentyl)-1H-indol-3-yl](4-methoxy-1-naphthalenyl)-","2-(4-morpholinyl)benzothiazole","1,4,10-Trioxa-7,13-diazacyclopentadecane, 7,13-bis[(4-nitrophenyl)methyl]-","1-Stearoyl-2-arachidonyl-sn-glycero-3-phosphocholine","8-Geranyl-7-hydroxycoumarin","Bromobutide","Methanone, [1-(2-hydroxypentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-","Tetradecylphosphonate","1-Palmitoyl-2-linoleoyl-rac-glycerol","N6-me-da","Aspidocarpine","1-O-octyl-2-O-(N-methylcarbamoyl)-sn-glyceryl-3-phosphorylcholine","15-Deoxy-.DELTA.12,14-prostaglandin J2 biotinamide","2-Oxiraneoctanoic acid, .eta.-hydroxy-3-octyl-","17alpha-hydroxyprogesterone","1,3-Propanediol, 2-amino-2-[2-[4-[[6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexyl]oxy]phenyl]ethyl]-","Arg-Leu-Arg","Val-Ile","Ile-Gly-Ile","Dinor-12-oxophytodienoic acid","5-(3-Pyridinyl)-1,3,4-thiadiazole-2-thiol","Triethanolamine","3,4-Dimethylbenzaldehyde","22-(Acetyloxy)-16-hydroxyolean-12-en-3-yl 2-O-hexopyranosylhexopyranosiduronic acid","N-Desmethylzolmitriptan","Tetraethylammonium cation","4-Androstene-11.beta.,17.beta.-diol-3-one","Withaferin A","Neohesperidose","Phenylalanine","Bohemine","Sorbitan monopalmitate","Lycorine","Latanoprost","Nifedipine","2-Methoxyestradiol","Scropolioside d","Morpholine","5'-Fluoro-2'-hydroxy-4-methylchalcone","Alpha-codeimethine","Ser-Arg","Tenuazonic acid","Methyl L-pyroglutamate","Pentaethylene glycol","Mevastatin","N-(Dodecanoyl)-1-.beta.-glucosyl-sphing-4-enine","3-Phenylazopyridine-2,6-diamine","Harringtonine","N,N-Bis(2-hydroxyethyl)glycine","Trifloxystrobin","Sarafloxacin","Amprenavir","1-O-Hexadecyl-2-deoxy-2-thio-R-(heptanoyl)-sn-glyceryl-3-phosphocholine","1-Hexadecyl-sn-glycero-3-phosphocholine","D-erythro-Sphinganine","2-Amino-2-methyl-1-propanol","Tryptamine","Crotonic acid","Chlorprothixene","Gln-Phe-Arg","Amisulpride","Morphine","1-Deoxy-1-(methylamino)-D-galactitol","Promazine","Creatine","2-Hydroxy-4,6-dimethylpyrimidine","Oxandrolone","Diisodecyl phthalate","4'-Deoxyprovincialin","7-Keto-3.alpha.,12-.alpha.-dihydroxycholanic acid","Tazettine","Pro-Ala","Cytosine","Thiamine cation","Dimepiperate","PyroGlu-Gln-Arg","N-Benzyl-1-methyl-1H-tetraazol-5-amine","(3E)-4-(1-Methyl-1H-indol-3-yl)-3-buten-2-one","Guanidinosuccinic acid","Arachidonoylserinol","(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-methyl-3H-1,4-benzodiazepin-2-one","Met-Arg","Tyr-Arg","Hirsuteine","D-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-","4-Bromoindole","(6E)-Heptadeca-6,16-diene-1,2,4-triol","Sulfanilate","(+) Biotinyl-6-aminohexanoic acid","Benzoylnorecgonine",".gamma.-Muricholic acid","4-Methyl-1H-pyrazole","D-Glucosamine 1-phosphate","Hypaphorine","1-(4-Methoxybenzyl)-4-piperidinylamine","5-[4-(Isopentyloxy)phenyl]-5-methyl-2,4-imidazolidinedione","N-Hexanoyl-L-homoserine lactone","(.+,-.)-2-Methylarachidonoyl-2'-fluoroethylamide","Cyclo(proline-leucine)","(5-Benzoyloxy-1,2,6-trihydroxycyclohex-3-en-1-yl)methyl benzoate","2-Acetyl-3-ethylpyrazine","2,8,9-Trimethyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane","6-Methyl-5-hepten-2-one","3-(5-hydroxy-2,2,7,8-tetramethyl-6-oxo-7,8-dihydropyrano[3,2-g]chromen-10-yl)hexanoic acid","Caffeoyl alcohol","Cilastatin","Trp-Ala","Ala-Ser-Lys","Di-dihydrocaffeoyl spermidine","(3r,7r,9s,10s,12s,13r,14s,17r)-17-((2r)-6,7-dihydroxy-6-methylheptan-2-yl)-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthrene-3,7,12-triol","2,4-Dimethylnicotinic acid","Di-p-coumaroylputrescine","Arg-Gln-Arg","Benzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-","Repaglinide","Hirsutine","4-(Thiophen-2-yl)benzene-1,2-diamine","Pyridaben","Syringolin C","Tyr-Leu","5-Amino-2-(3,4'-dihydroxy-4,4,7,8a-tetramethyl-6'-oxospiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-3,8-dihydrofuro[2,3-e]isoindole]-7'-yl)-5-oxopentanoic acid","Pro-Trp","Bimatoprost amide","Heptaethylene glycol p-tert-octylphenyl ether","Glutamine","1,2-Dimethylimidazole","(R)-Butyrylcarnitine","Gly-Pro-Arg-Pro-amide","Peramivir","2-[4-(Propan-2-yloxy)phenyl]quinoline-4-carboxylic acid","N-Cyclohexyl-N'-(1,2,3,4-tetrahydro-1-naphthalenyl)urea","1-Hexadecyl lysophosphatidic acid","2,5,7-Trimethyl-4(1H)-quinolinone","5-Aminosalicylic acid","(2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid","9Z-Octadecenoic acid, (2S)-3-[(hydroxymercaptophosphinyl)oxy]-2-methoxypropyl ester","Vitamin C","3-Dodecyloxypropylamine","Desmethylolanzapine","12-cytisineacetamide","Tyramine","2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[3-(triazol-2-yl)anilino]pyrimidine-5-carboxamide","20-HETE","Atenolol-desisopropyl","(2E,4E,10Z)-N-(2-Methylpropyl)hexadeca-2,4,10-trienamide","L-Citrulline","4-acetamidobutanoate","Rutamarin","Ethyl 2-(3-chloropyridin-2-yl)-5-oxopyrazolidine-3-carboxylate","1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine","4-Imidazoleacrylic acid","2,4-Diphenylbutanoic acid","Ser-Ala","Nalidixic acid","Ile-Gln-Arg","1,5-Hexadien-3-ol","[3-Nitro-4-(1-piperidinyl)phenyl](phenyl)methanone","DL-Octopamine","Feruloyl putrescine (isomer of 1178)","Withanolide B","4-ohe1-1-n3ade","Thr-Lys-Lys","Glycerophosphocholine","[(2r,3r,4s,5s,6r)-3-acetyloxy-2-(acetyloxymethyl)-5-hexanoyloxy-6-[(2s,3r)-2,3,4-trihydroxybutoxy]oxan-4-yl] tetradecanoate","Senkirkin","1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone","DL-phenylalanine","Fluprostenol serinolamide","3-Acetyl-7-diethylaminocoumarin","Fenamiphos sulfone","Desmethylcitalopram","N-(2,3-Dimethoxybenzyl)-1,2,3,4-tetrahydro-1-naphthalenamine","NG,NG-Dimethyl-L-arginine","Deoxypeganine","Trilostane","2-(Aminomethyl)-4-methylpentanoic acid","Tyr-Pro","1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-.alpha.,.alpha.- dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid","Propanedioic acid, 2-(2-methylpropyl)-, 1,3-dimethyl ester","Dipivefrine","Methyl 4-hydroxy-3,5-dimethoxybenzoate","2-([1,1'-Biphenyl]-4-yloxy)ethylamine","1-Dodecyl-2-pyrrolidinone","Nizatidine","Cycloxydime","N-(4-Chlorobenzoyl)-3-(4-methoxyphenyl)-.beta.-alanine","Cinobufotalin","Prostaglandin D2 ethanolamide","Diethylcarbamazine","1H-Indole-3-carboxamide, N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-(5-hydroxypentyl)-","Arg-Leu","Bergamotin","Flurprimidol","Benzamide, N-[2-(dimethylamino)ethyl]-N-methyl-4-[[[[4-[4-(4-morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]amino]carbonyl]amino]-","(2S,3S)-3-Hydroxyleucine","7-Hydroxy-10-(2-hydroxypropan-2-yl)-2,2a,4,7b,13a-pentamethyl-6-oxo-2a,3,4,6,7,7a,7b,8,9,10,11a,12,13,13a-tetradecahydro-2H-oxeto[2',3':1,5]cyclopenta[1,2-h]pyrano[3,2-a]xanthene-3,8-diyl diacetate","Methacholine cation","5-Aminovaleric acid","Glu-Gly-Arg","5-(2-Thienyl)-1,3,4-oxadiazole-2(3H)-thione","3,6-Dimethylbenzene-1,2-diamine","4-Acetyloxy-8-(3-oxo-2-pent-2-enylcyclopenten-1-yl)octanoic acid","6-Ketoprostaglandin E1","N-(Phenylacetyl)urea","Tyr-Tyr","1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine","D-Glucosamine","7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin","8-Hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]-2(1H)-quinolinone","His-Leu","Val-Thr","Asn-Gly-Arg","(+)-Muscarine cation","Trp-Pro","N-[(1E)-2-(4-Nitrophenyl)-1-azavinyl]-2-(2-naphthylamino)acetamide","N-(Methylsulfonyl)-13-(3-pentyloxiranyl)-5Z,8Z,11Z-tridecatrienamide","Arg-Phe","(3,8-Dihydroxy-6,9-dimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-3-yl)methyl acetate","Tabersonine","Aldosterone","1,2,3,6-Tetrahydrobenzylalcohol","Homatropine","(3aR,4S,6E,9Z,11aS)-4-Hydroxy-6,10-dimethyl-3-methylidene-2,8-dioxo-2,3,3a,4,5,8,11,11a-octahydrocyclodeca[b]furan-11-yl (2Z)-2-methylbut-2-enoate","Adenylyl(3'-5')cytidine","Indoline","Aniline","L-Tyrosine, ethyl ester","5.beta.-Pregnane-3.alpha.,17-diol-20-one","Leukotriene B4 ethanolamide","N-Benzyl(2-methoxyphenyl)methanamine","Val-Val-Arg","N-(sec-Butyl)-N-(4-(sec-butyl(trifluoroacetyl)amino)phenyl-2,2,2-trifluoroacetamide","Gelsemine","Antibiotic F 1839A","3-[8-(2-Hydroxypropan-2-yl)-3-methoxycarbonyl-3,4a,7,10a-tetramethyl-5-methylidene-1,4-dioxo-6,6a,8,9,10,10b-hexahydrobenzo[h]isochromen-7-yl]propanoic acid","Ivabradine","N-Phenylacetyl-L-prolylglycine ethyl ester","Glufosinate","2-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]ethylamine","Palmitoylcarnitine","Chlormadinone acetate","Corydaline","Scropolioside B","Pencycuron","2-Ethyl-2-phenylmalonamide","Indole-3-butyric acid","Echimidine","Palmitoyl-L-carnitine","2,3,14,20,22,25,26-Heptahydroxyergost-7-en-6-one","(.+,-.)-N,N-Dimethyl-3,4-methylenedioxyamphetamine","Procaine","Mildronate","Protoporphyrin IX","Heptadecasphinganine","2'-Deoxyadenosine","Eszopiclone N-oxide","Asn-Asn","Thr-Pro","Thiamet G","Arg-Trp","MeOSuc-Ala-Ala-Pro-Val-AMC","Nalorphine","Vitamin k1","Leucine","Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester","[(4,6-Dimethyl-2-pyrimidinyl)amino]acetic acid","3-Hydroxybutyrylcarnitine","Nordazepam","5-Methyl-2'-deoxycytidine","Citalopram","3-Hydroxy-6-[[(E)-3-hydroxy-2,4-dimethylhept-4-enoyl]amino]-2,4-dimethyl-5-oxohexanoic acid","Ala-Gly-Arg","Desferrioxamine d2","Val-Gln","3,4-Bis(benzyloxy)benzaldehyde","3-Fluoro-7-methylimidazo[1,2-a]pyridine-2-carboxylic acid","1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole","1-(2,2,2-Trifluoroethyl)-4-piperidinylamine","3-Amino-2,3-dihydrobenzoic acid","1-Palmitoyl-sn-glycero-3-phosphocholine","Ethoxyquin","N-acetylglucosamine","Pro-Pro","Atazanavir","2-Hydroxy-3-methoxybenzenemethanol","Perifosine","3-Oxo-4-cholestenoic acid","Trp-Arg-Arg","Galacto-N-biose","D-erythro-Imidazolylglycerol phosphate","p-Coumaric acid","Arg-Ala-Lys","N1-Benzyl-N2,N2-diethyl-1,2-ethanediamine","5,10-Dihydro-10-phenophosphazinol 10-oxide","1H-Indole-3-methanamine, 5-(2-amino-5-pyrimidinyl)-N,N-diethyl-1-octyl-","1-Piperidinecarboxamide, N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-","16-Oxoandrostenediol","Irinotecan","1,6-Dioxacyclohexadecane-7,16-dione","2-Acetamido-2-deoxy-3-O-(.beta.-D-galactopyranosyl)-D-glucopyranose","3,11,20-Trihydroxypregn-8-ene-4-carboxylic acid","Met-Ala-Lys","2-(4-Pyridinyl)-2,3-dihydro-1H-perimidine","Levorphanol","Prostaglandin F2.alpha. serinolamide","4-Amino-5-(1H-benzimidazol-1-ylmethyl)-4H-1,2,4-triazole-3-thiol","(Methylenecyclopropyl)acetyl-L-carnitine","Doxazosin","3-Hydroxy-2',4,4',6'-tetramethoxychalcone","Olanzapine","Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-","1-O-Octadecyl-sn-glyceryl-3-phosphorylcholine","N-((7E,11Z)-6,13,14-Trihydroxy-3-(1H-indol-3-ylmethyl)-4,5,10,12-tetramethyl-1,17-dioxo-2,3,3a,6,6a,9,10,13,14,15,16,17-dodecahydro-1H-cyclotrideca[d]isoindol-15-yl)acetamide","Schizandrin A","Schizandrin B","1H-Indazole-3-carboxamide, N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-pentyl-","(E)-4-[4-[(E)-Hept-1-enyl]-2,5-dihydroxy-3-(hydroxymethyl)-7-oxabicyclo[4.1.0]hept-3-en-6-yl]-2-methylbut-2-enoic acid","Stearoylcarnitine","Helicin","5-Aminopentanamide","(1s,2r,4as,6ar,6br,10s,12ar,14bs)-1,2,6b,9,9,12a-hexamethyl-10-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1h-picene-4a,6a-dicarboxylic acid","4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-","Ethinyl estradiol","His-His-Arg","7-Amino-4-methylquinolin-2-ol","N-Arachidonoyl-.gamma.-aminobutyric acid","Diazepam","7.alpha.-Hydroxy-4-cholesten-3-one","2'-O-Acetyl-3'-O-(4-hydroxy-2-methoxy-6-methylbenzoyl)uridine","13-Hydroxy-6-(1-hydroxyethyl)-12,14-dimethyl-3-methylidene-15-nonyl-9-(propan-2-yl)-1-oxa-4,7,10-triazacyclopentadecane-2,5,8,11-tetrone","Dimethyl 2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate","Lipoxin A4","Lys-Val","Paraoxon","Pyrrocidine B","Tropinone","Hydromorphone","all-trans-4-Ketoretinoic acid","5-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole","Leu-Asn","Vincamone","Pheophorbide a","Pentobarbital","Neomycin","Amlodipine","Myclobutanil","Choline cation","Lys-Tyr-Arg","Dehydropipernonaline","4-(4-Chlorophenyl)-2-phenyl-1,3-thiazole","[2-(6,7-Dimethoxyquinazolin-4-yl)-5-(2-pyridyl)-1,2,4-triazol-3-yl]amine","8-iso-Prostaglandin A2-biotin","[6,10a-Dihydroxy-4-(hydroxymethyl)-4,7,11b-trimethyl-9-oxo-1,2,3,4a,5,6,6a,7,11,11a-decahydronaphtho[2,1-f][1]benzofuran-5-yl] acetate","6H-2-Benzopyran-6-one, 5-chloro-3-(3,4-dihydroxy-3,5-dimethyl-1-hepten-1-yl)-7,8-dihydro-7,8-dihydroxy-7-methyl-","1-(3,4-Dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-one","Methoprotryne","N.epsilon.-Methyl-L-lysine","Kanamycin A","Pyrimidifen","Dihydrocelastryl diacetate","1.alpha.-Methyl-5.alpha.-androstan-3.alpha.,17.beta.-diol glucuronide","Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-","N-[(3s,5s,7s)-Adamantan-1-yl]-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide","Dinotefuran","Cannabinol","4-Nitrosodiphenylamine","N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide","Pipradrol","2,3-Dihydroxypropyl octadecanoate","2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-hydroxyethoxy]phenyl]methyl]-","Propafenone","Ametoctradin",".alpha.-Pyrrolidinooctanophenone","(Diethylamino)(oxo)acetic acid","Val-Phe","Anastrozole","1-Hexadecylpyridinium cation","L-Phenylalanine, methyl ester","4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol","Benalaxyl","Pentazocine","Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-","1-O-Hexadecyl-2-O-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glyceryl-3-phosphorylcholine","1,2-Bis(O-octanoyl)-sn-glycerylphophorylcholine","Kukoline","Turkesterone","Penbutolol","2-(1-Adamantyl)-N-hydroxyacetamide","Ciprofloxacin","Cyanazine","(2E)-1-(4-Methoxyphenyl)-3-(4-pyridinyl)-2-propen-1-one","N-2-Hydroxyethylpiperazine-N-3-propanesulfonic acid","3-Hydroxyhexadecanoylcarnitine","Lys-Ile-Arg",".beta.-Muricholic acid","N-Methyltryptophan","1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-(ethoxymethyl)-.alpha.,.alpha.-dimethyl-","Praziquantel","(7E)-11,12,13-Trihydroxy-4,5,8-trimethyl-3-(2-methylpropyl)-3,3a,4,6a,9,10,11,12,13,14-decahydro-1H-cycloundeca[d]isoindole-1,15(2H)-dione","Guanosine","Griseophenone B","Neoandrographolide","Trimethoprim","Cytochalasin E","7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin","Rabeprazole","4-(4-Methylpiperazino)benzoic acid","Cytochalasin A","Chlorpromazine","5'-S-Methyl-5'-thioadenosine","Dehydrosalsolidine","Neomangiferin","3-deoxo-3beta-acetoxydeoxydihydrogedunin","N-3-Oxotetradec-7Z-enoyl-L-homoserine lactone","Val-Glu-Lys","2,4-Diethyl 5-acetamido-3-methylthiophene-2,4-dicarboxylate","5-[Bis(2-chloroethyl)amino]uracil","3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-","Verruculotoxin","N-(2-Amino-4-ethoxyphenyl)acetamide","5-Methoxycarbonylamino-N-acetyltryptamine","Pro-Lys-Arg","Lys-Ile","N,N-Dimethylsphingosine","Hydroxybutorphanol",".alpha.-Pyrrolidinononanophenone","trans-Zeatin","4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)butanoic acid","2-{[4-(Dipentylamino)-2-hydroxyphenyl]carbonyl}benzoic acid","trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane","HC Toxin","N-(4-Ethoxyphenyl)-N'-(4-fluorophenyl)urea","3.alpha.-Hydroxy-7-oxo-5.beta.-cholanic acid","Imazamox","D-Mannosamine","Pindolol","1-(4-Bromobenzyl)-4-(2-pyridinylmethyl)piperazine","2-Amino-4-methoxybutanoic acid","Huperzine B","Acetyl-DL-carnitine","2,4-Diamino-6-nitrotoluene","5-(Trifluoromethyl)pyridine-2-carboxylic acid","3-Hydroxy-N-(4-methylphenyl)-2-naphthamide","4-Androsten-17.beta.-ol-3-one sulfate","Ser-Ile-Lys","Puromycin","Cyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl]","2,5-Dimethyl-4-pyrimidinamine","N-Cyclohexyl-N'-(tetrahydro-2-furanylmethyl)urea","2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-","1H-Indole-3-carboxylic acid, 1-(cyclohexylmethyl)-","Man3 a","L-Arginine, methyl ester","Phe-Met-Arg","Pyroquilon","Testosterone cypionate","Thr-Ala","5-(2-Phenylethyl)-1H-pyrazole-3-carboxylic acid","Emetine","Aspartic acid","3-Benzoylalanine",".alpha.-Methyl-L-tyrosine","Gly-Val-Lys","Swainsonine","(7E)-11,12-Dihydroxy-13-methoxy-4,5,8-trimethyl-3-(2-methylpropyl)-3,3a,4,6a,9,10,11,12,13,14-decahydro-1H-cycloundeca[d]isoindole-1,15(2H)-dione","1,2-Dilauroyl-sn-glycero-3-phosphate","(4-Benzylpiperidin-1-yl)(4-methylphenyl)methanone","1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine","(-)-Epinephrine","Suberylglycine","4-(tert-Butylamino)-6-ethylamino-5H-1,3,5-triazin-2-one","[(2R,3R,4S,5S,6R)-2-(Acetyloxymethyl)-5-hexanoyloxy-3-hydroxy-6-[(2S,3R)-2,3,4-trihydroxybutoxy]oxan-4-yl] tetradecanoate","1-(1-Phenylethyl)hydrazine","Hexanamide, N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-","N-[4-(4-Ethylpiperazin-1-yl)phenyl]benzo[g]quinolin-4-amine","Sulfamonomethoxine","5.alpha.-Androstan-17.beta.-ol-3-one","N-Benzyl-2-(2-fluorophenoxy)ethanamine","Argininosuccinic acid","Malaoxon","3-Methyl-L-histidine",".beta.-Homoproline","Multifloroside","Met-Met-Arg","Ginsenoside Rf","N,N-Dimethyl-N-(2-phenoxyethyl)-1-dodecanaminium cation","Levofloxacin","Etrimfos","Sucrose","9-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione","(4r)-4-((5s,7r,9s,10s,13r,14s,17r)-7-hydroxy-10,13-dimethyl-3-oxohexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid","tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate","2'-Deoxyguanosine 5'-monophosphate","rac-N'-Nitrosonornicotine 1-N-oxide","Trachelanthine","17-Oxodexamethasone","Echinulin","Serpentine cation","Safranin","1-Deoxynojirimycin","Metoclopramide","6-methoxybenzoxazolin-2(3h)-one","Zanamivir","2-(1-Phenylcyclopentyl)acetic acid","4-Hydroxy-L-isoleucine","Dye X-732-100Ea","Ophthalmate","Carbobenzyloxyglycyl-L-norleucine methyl ester","1-(Tetrahydro-2H-thiopyran-4-yl)piperazine","1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-4-hydroxy-.alpha.-(1-methylethyl)-2-oxo-, (.alpha.S)-","Trichostatin A","N-Acetyl-.beta.-D-mannosamine",".gamma.-Glu-.epsilon.-Lys","1-(1-Benzylpiperidin-4-yl)-4-(methylsulfonyl)piperazine","Leu-Ala","Taurocholic acid","Fingolimod","Val-Pro","Lopinavir","Mecillinam","Fenoxycarb","Spectinomycin","Dienestrol","Methyl 1-piperazinecarboxylate","Albendazole sulfone","Lys-Lys-Lys","Dihydro-.beta.-erythroidine","Polygodial","Hydroxygardnutine","Perindopril","1-Behenoyl-2-hydroxy-sn-glycero-3-phosphocholine","2-heptyl-3-hydroxy 4-quinolone","Trihydroxycoprostane","Ivacaftor","Demecolcine","N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide","2-(1-Piperidinyl)ethyl 1-phenylcyclopentanecarboxylate","Val-Tyr","Ala-Leu-Arg","Arg-Glu","N5-(1-Imino-3-butenyl)-L-ornithine","Zearalenone","Rotundine","Tetraethylene glycol","1,2-Benzenediamine, 4-methyl-N1-(3-phenylpropyl)-","Leu-Glu-Arg","Cumaroylspermidine","2-(4-Amino-1-piperidinyl)ethanol","Crufomate","{[(4-Hydroxyphenyl)acetyl]amino}acetic acid","3'-Fluoro-.alpha.-pyrrolidinopropiophenone","1,2-Diarachidonoyl-sn-glycero-3-phosphocholine","4-Cholestenone","Ritalinic acid","Alprenolol","Mepacrine","Nonanohydrazide","Oleandrin","Ipecoside","Prosulfocarb","Creatinine","His-Glu","Dexpanthenol","Dexamethasone","Oleana-1,9(11)-dien-28-amide, 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-","(4S,4aR)-4-(Hydroxymethyl)-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one","N2-Isobutyryl-2'-deoxyguanosine","Pyridoxine","Orphenadrine","L-Arginine ethyl ester","2-(2-Amino-4-nitroanilino)ethanol","Fallacinol","Galiellalactone","trans-Ferulic acid","4-Amino-2-methyl-5-pyrimidinemethanol","Oxethazaine","(+)-Chlorpheniramine","Stachydrine","Nicotinamide riboside cation","Carisoprodol","Cyclostachnine B","Arachidonoyl ethanolamide","1-(1Z-Hexadecenyl)-sn-glycero-3-phosphocholine","1-(4-Ethoxyphenyl)urea","1-(2-Hydroxyethyl)pyrazole","Acepromazine","4-Quinazolinamine, N-[1-(cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-","Linoleoyl ethanolamide","Phe-Thr-Arg","Gomisin J","4-Imidazoleacetic acid","O-t-Butyl-L-serine, methyl ester","Gomisin D","Isoxathion","Urobilin","16.alpha.-Hydroxyestrone","Betaine","2.alpha.-Mannobiose","17-Phenyltrinorprostaglandin E2 serinolamide","Phenacetin","1-Benzyl 2-(1-ethylhexyl) phthalate","Jasmonic acid","Ala-Glu-Arg","Cholestan-3-one, (5.alpha.)-","Asn-Lys","Terconazole","Gamma-tocotrienol","Piperettine","N-Benzyl-4-tert-butylbenzamide","L-beta-homothreonine","Atenolol","Cytidine","Pipernonaline","3-(6-Amino-9H-purin-9-yl)propan-1-ol","Lys-Phe-Arg","(1,4a-Dimethyl-6-methylidene-5-(2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl)methyl 6-O-(carboxyacetyl)hexopyranoside","N1-(4-Nitrophenyl)-1,3-propanediamine","N-(4,6-Dimethyl-2-pyridinyl)-4-ethoxybenzamide","Thalsimine","(3Z)-6-Hydroxy-3-(1H-imidazol-5-ylmethylidene)-12-methoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione","Methyl arachidonyl fluorophosphonate","Ethylmorphine","Val-Gln-Arg","Imazamethabenz-methyl","3-Hydroxy-4,4,6a,9,12b-pentamethyl-3,4,4a,6,6a,12,12a,12b-octahydro-2H,9H-benzo[f]pyrano[2,3-b]chromene-1,11(5H,10H)-dione","Alfentanyl","Gly-Lys","1-(3,4-Dihydroxy-5-methoxyphenyl)-7-(3,4-dihydroxyphenyl)heptan-3-one","Hydrocortisone","7-[(2,6-Dihydroxy-2,5,5,8a-tetramethyldecalin-1-yl)methoxy]coumarin","4-(2-Cyclohexylethoxy)aniline","Piperonyl sulfoxide","Protubonine A","N-Heptanoyl-L-homoserine lactone","2-(4-Amino-1-piperidinyl)-N-methylacetamide","Tris(2-butoxyethyl) phosphate","7-Methyl-4,5-dihydroindeno[1,7-bc]acridine","Methanone, [5-(3-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-","8-Quinolinyl 1-piperidinecarboxylate","4-Amino-2-methylbenzamide","2-Hydroxyestrone","Phosmet","N4-acetylsulfadimethoxine","Glutathione, oxidized","Ractopamine","Ser-Asn-Lys","1-Palmitoylglycerol","Myristoyl-L-carnitine","Codeine","Methanone, (1-naphthalenyl)(9-pentyl-9H-carbazol-3-yl)-","Progesterone","6.beta.-Hydroxytriamcinolone acetonide","5'-(Furan-3-yl)-4a-hydroxy-4,7-dimethylspiro[5,6,7,8a-tetrahydro-1H-naphthalene-8,3'-oxolane]-2,2'-dione","Xanthohumol","N1-(2-Nitrophenyl)-1,3-propanediamine","8,9-Dihydroxy-5Z,11Z,14Z-eicosatrienoic acid","7-Hydroxycoumarinyl .gamma.-linolenate","2-Amino-4-methylpentanoic acid ethylamide",".gamma.-linolenic acid",".delta.-Tocotrienol","4-Aminopyridine","2-{4-[3-(Trifluoromethyl)phenyl]piperazino}-1-ethanamine","4-Guanidinobutyric acid","Morroniside","Atropine","1-Benzyl-2-ethyl-1,5,6,7-tetrahydro-4H-indol-4-one","Mavorixafor","Rhynchophylline","17-Trifluoromethylphenyltrinorprostaglandin F2.alpha. methyl ester","3-Indoleacrylic acid","Lisinopril","Thiamine monophosphate","N-(4-Aminobenzoyl)-.beta.-alanine","Podofilox","Alloxydim","Methyl (19.alpha.,20.alpha.)-11-methoxy-19-methyl-16,17-didehydrooxayohimban-16-carboxylate","2-methoxy-4-pentadecylbenzoic acid","2'-Deoxyinosine","Castanospermine","1H-Indazole-3-carboxamide, 1-(5-hydroxypentyl)-N-tricyclo[3.3.1.1(3,7)]dec-1-yl-","Muramic acid","3-(Dimethylamino)propyl imidothiocarbamate","1-Palmitoyl-2-azelaoylphosphatidylcholine","(3'S,4S,6R,7R)-7-Hydroxy-3',6,7,14-tetramethyl-8H,17H-spiro[2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-4,2'-oxirane]-3,8,17-trione","Pentostatin","Nalbuphine","Flindersine","4'-O-.beta.-D-Glucosyl-5-O-methylvisamminol","N-Arachidonoyltaurine","Peruvinine","trans-4-(Aminomethyl)cyclohexanecarboxylic acid","Tafluprost ethylamide","2'-Deoxycytidine","Lys-Gln-Arg","N-.alpha.-Acetyl-L-ornithine","Linezolid","2,6-Di-tert-butyl-4-(4-morpholinylmethyl)phenol","N-(4-Bromo-3-methylphenyl)-3-(morpholin-4-yl)propanamide","Val-His","L-.beta.-Homoglutamine","2,4-Di-tert-butyl-6-[(dimethylamino)methyl]phenol","Austalide D","(9Z,12Z)-15-Hydroxy-16-methoxyoctadeca-9,12-dienoic acid","2-(4,4-Difluorocyclohexyl)ethan-1-amine","Thr-Val","(-)-Riboflavin","Clerodin","Lincomycin","Spironolactone","4-Methoxy-N-(4-nitrophenyl)benzamide","Ile-Pro","Butanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-","Lys-Phe","3-[(Cholamidopropyl)dimethylammonio]-1-propanesulfonate","Metolazone","2-(5-acetyl-2,3-dihydro-1-benzofuran-2-yl)prop-2-enyl 3-methylbutanoate","1H-Indazole-3-carboxamide, N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-[(4-fluorophenyl)methyl]-","(3R,6S,6aS,10S,12aS,13aR,14S)-1-Ethyl-12a,14-dihydroxy-6-methoxy-3-methyl-8-oxotetradecahydro-7H-3,6a,13-(epiethane[1,1,2]triyl)-7,10-methanooxepino[3',4':4,5]benzo[1,2-b]azocine","6-Ketotestosterone enanthate","Dye X-26647-194","Pyridate","Niacinamide","Salsolinol","Serotonin","4-(3,5-Dimethyl-4H-1,2,4-triazol-4-yl)piperidine","(2R)-3-(tert-Butylamino)propane-1,2-diol","N-3-Oxohexadec-11Z-enoyl-L-homoserine lactone","N-Tris(hydroxymethyl)methyl-4-aminobutanesulfonic acid","Nordihydroguaiaretic acid","L-Homoarginine","N-Methyl-L-isoleucine","Clidinium cation","1,4-D-Xylobiose","Isovaleryl-L-carnitine","3-Quinolinecarboxamide, 1,4-dihydro-8-methoxy-4-oxo-1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-","Osthole","Estra-1,3,5(10),7-tetraene-3,17.beta.-diol","N-(3-Methoxyphenyl)urea","N-(3-Methylbutanoyl)valine","2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide","13-oxoode","Crotamiton","L-Homocitrulline","1-O-Hexadecyl-2-O-(2E-butenoyl)-sn-glyceryl-3-phosphocholine","1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-","all-trans-Retinoic acid methyl ester","Benfuresate","Hexylamine","Aprepitant .beta.-glucuronide (position of glucuronide on triazolone ring uncertain)","4-[3-(Trifluoromethyl)benzyl]piperidine","5-Androstene-3.beta.,17.beta.-diol","L-leucyl-l-proline","N-(.alpha.-Linolenoyl)tyrosine","Budesonide","Metaflumizone","3'-Methyl[1,1'-biphenyl]-3-carboxylic acid","Buturon","1-(4-Aminobutyl)urea","Myristamine oxide","Sulfamic acid, N,N-dimethyl-, 4-nitrophenyl ester","1,24-Dihydroxyvitamin D3","Harmine","3-{3-oxo-2H,3H-[1,2,4]Triazolo[4,3-a]pyridin-2-yl}propanoic acid","Acetyleugenol","Anabasamine","Phytosphingosine","Pro-hyp","Fenpropimorph","3,6-Diphenylcyclohexane-1,2-diol","3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane","Tyr-Tyr-Lys","Evoxine","Rhodamine B cation","Lewis X trisaccharide","Propranolol","Harpagoside","[4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl]piperazinomethanone","Tyrosine","Leu-Gln-Arg","(2E)-3-Cyclohexyl-2-butenoic acid","Levamisole","2-Pyrrolidinone, 5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-, (5R)-","Enniatin a1","5-Isopropyl-3-isoxazolecarboxylic acid","2-(2',3',4'-Trihydroxybutyl)quinoxaline","Hellebrigenin-3-O-.beta.-glucoside","Quinine","2S-Amino-4E-pentadecene-1,3R-diol","Lys-Ala","2-{[5,6-Bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}ethanol","Hydroxychloroquine","N-(2'-Cyanobiphenyl-4-ylmethyl)-L-valine methyl ester","1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)ethanone","Methyl (2E,8E)-9-[3a-hydroxy-6,7-dimethyl-1-(2-methylpropyl)-3-oxo-2,4,7,7a-tetrahydro-1H-isoindol-4-yl]-4,5-dihydroxy-8-methylnona-2,8-dienoate","5-(4-Methylpiperazin-1-yl)-5-oxopentanoic acid","5-Chloro-2-(4-propionyl-1-piperazinyl)aniline","Hypoxanthine","Phe-Arg","Ile-Phe-Arg","Palmitoyl ethanolamide","Linamarin","1,7-Bis(4-hydroxyphenyl)heptan-3-yl 6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranoside","15.beta.-Hydroxycyproterone acetate","Betaxolol","1-Decanoyl-2-hydroxy-sn-glycero-3-phosphocholine","Leu-Phe","3-(.beta.-D-Galactopyranosyloxy)-2-hydroxypropyl (9Z,12Z)-octadeca-9,12-dienoate","Androstan-3-ol-17-one 3-glucuronide","4,6,8-Trimethylquinolin-2-ol","Levallorphan","Cyclopropanecarboxamide, N-[(1S)-2-[4-(5-bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-phenyl-, (1R,2R)-","Saluamine","Phenylethylamine","Gln-Leu-Lys","N8-Acetylspermidine","N5-(1-Iminobutyl)-L-ornithine","Ascorbic acid 6-palmitate","Pro-Met","3-Hydroxyoleylcarnitine","Metolachlor morpholinone","1-(3-Bromophenyl)-3,5-dimethylpyrazole","Pentamethylene bisacetamide","(2.beta.,3.alpha.,5.alpha.,16.beta.,17.beta.)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane","N-(9-(Butan-2-yl)-21-(4-methoxybenzyl)-18,22-dimethyl-5,8,11,16,20,23-hexaoxo-6-(propan-2-yl)icosahydro-5H,16H-dipyrrolo[2,1-f:2',1'-o][1,4,7,10,13,16]oxapentaazacyclononadecin-17-yl)acetamide","(.+,-.)-Quinuclidinyl benzilate","Trp-Gly-Lys","8-(3-Octyl-2-oxiranyl)octanoic acid","2-(3-Hexyl-4-methyl-2,5-dioxopyrrol-1-yl)-3-hydroxypropanoic acid","Phe-Tyr","Ile-Val-Lys","Docosan-1-amine","(2R)-N-(3-Ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide","(2,6-Dihydroxy-4-methoxyphenyl)(4-hydroxy-2-methoxy-6-methylphenyl)methanone","Quinoline-2,8-diol","N,N'-Diacetylcystine","3-(3,4,5-Trimethoxyphenyl)propanohydrazide","Adenine","1H-1,2,3-Triazole-1-octanamide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-","Gln-Lys","3-[N,N-Bis(2-hydroxyethyl)amino]-2-hydroxypropanesulfonic acid","2-(4-Fluorophenyl)-N-(2-methoxybenzyl)ethanamine","1-Stearoyl-sn-glycerol 3-phosphocholine(LPC(18:0))","Hydroxycerivastatin","2-(4-tert-Butylbenzoyl)benzoic acid","2-(2,3-Dimethylphenyl)-7-methyl-1,2,4-triazaspiro[4.5]decane-3-thione","2-(4-tert-Butylphenoxy)ethanamine","2-Hydroxyatorvastatin lactone","Hydroquinidine","Enalaprilat","Cys-Leu-Lys","Purine","(5E)-4,7,8-Trihydroxy-2-(2-hydroxypentyl)-9,9-dimethyl-3,4,7,8-tetrahydro-2H-oxecin-10-one","Ile-Arg","13,14-Dihydro-15-ketoprostaglandin D1","DL-tyrosine","1-Methyl-L-histidine","Propargite","Methyl 3-[3,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-2-[[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]methyl]-4-methoxy-5-oxofuran-2-carboxylate","2-Naphthalenecarboxamide, N-[(1S)-2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-","Primaquine","Medroxyprogesterone 17-acetate","Soyasaponin i","D-Desthiobiotin","2'-Deoxyadenosine 5'-monophosphate","Carnosol","L-Propionylcarnitine","2-methoxy-3,5-dimethyl-6-[(4z)-4-[(e)-2-methyl-3-(4-nitrophenyl)prop-2-enylidene]oxolan-2-yl]pyran-4-one","LNT","Lys-Gly","Benzoylecgonine","1,5-Pentanediamine","Pirimicarb","2-(1H-Indol-3-yl)-2-(4-methoxyphenyl)ethanamine","N-Methyl-L-histidine","4-[2-(6,7-dihydroxy-1,2,4a-trimethylspiro[3,4,6,7,8,8a-hexahydro-2h-naphthalene-5,2'-oxirane]-1-yl)ethyl]-2-hydroxy-2h-furan-5-one","(4R,10E)-3,11-Dimethyl-4,8,9,12-tetrahydro-4,7-(metheno)furo[3,2-c]oxacycloundecin-6-one","Caffeine","10-Nitrooleic acid","Scrophularoside A8",".alpha.-Tocotrienol","4-(1H-Inden-1-ylidenemethyl)phenylamine","2-(Dipentylamino)-2-(hydroxymethyl)-1,3-propanediol","2-Amino-N-cyclopentyl-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide","Methyl 1-(2-Methoxyethyl)-2-oxopyrrolidine-4-carboxylate","Maltotriose","Ethyl 4-methyl-5-[(propan-2-yl)oxy]-9H-pyrido[3,4-b]indole-3-carboxylate","15-Deoxy-.DELTA.12,14-prostaglandin J2 glutathione",".beta.-Alanylleucine","L-Methionine","N-Methyltyramine","3-Methyl-1-(4-nitrophenyl)-1H-pyrazol-5-ol","Methyldopa","N-Acetylhistamine","Pentedrone","2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl","N-(3-Methoxypropyl)-2-(phenylsulfanyl)acetamide","(3.beta.,4.alpha.,16.alpha.)-17-Carboxy-16-hydroxy-23-oxo-28-norolean-12-en-3-yl O-.beta.-D-galactopyranosyl-(1->2)-O-[.beta.-D-xylopyranosyl-(1->3)]-.beta.-D-glucopyranosiduronic acid","Methyl (9Z,14Z)-12,13,16-trihydroxyoctadeca-9,14-dienoate","Neofusapyrone","1-Monolinolenin","N.alpha.-Acetyl-L-lysine","(1R,4aR,4bS,6aS,9R,10R,10aS)-1-(Carboxymethyl)-10-hydroxy-2-(1-methoxy-2-methyl-1-oxopropan-2-yl)-1,4a,4b,9,10-pentamethyl-3,4,5,6,7,8,9,10a,12,12a-decahydro-2H-chrysene-6a-carboxylic acid","5-(2-Hydroxyethyl)-4-methylthiazole","Digoxigenin bisdigitoxoside","Succinic acid N,N-dimethylhydrazide","Val-Leu-Arg","Ile-Trp","Zectran","Cyprodime","Dinitramine","4-Amino-1,2-benzenediol","Ancymidol","Diferuloyl putrescine","Cys-Pro-Arg","Gln-Ala-Lys","N-Methyl-L-threonine","2-[(Dibenzylamino)carbonyl]benzoic acid","Pyridoxamine","4,4'-(Propane-2,2-diyl)bis(2-aminophenol)","Desferrichrome","Benzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]-","Ergosterol","Asclepin","3-Methoxy-4-(1,3-oxazol-5-yl)aniline","Amorfrutin A","2-Chloro-N-[2-(4-morpholinyl)ethyl]nicotinamide","Ginsenoside F1","S-Adenosylmethionine","His-Asn-Arg","Protriptyline","Isopropalin","Nylidrin","Mefenamic acid","1-(5,10-Dioxo-2,3,5a,6,7,8-hexahydro-1H-dipyrrolo[1,2-d:1',2'-f]pyrazin-10a-yl)propan-2-yl carbamate","Ala-Leu-Lys","L-Norvaline","2-Linoleoylglycerol","Ethyl [5-(methylcarbamoyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-3-yl]carbamate","Val-Lys","1-Pentadecanoyl-sn-glycero-3-phosphocholine","Methanone, [1-(hexahydro-1-methyl-1H-azepin-3-yl)-1H-indol-3-yl]tricyclo[3.3.1.1(3,7)]dec-1-yl-","Camptothecin","Manoalide","Thr-Cys-Arg","Leu-Glu","1-(2,5-Dimethylphenoxy)-3-(4-morpholinyl)-2-propanol","Montelukast acyl-.beta.-D-glucuronide","Labetalol","Desisopropyldisopyramide","Isogibberellin A3","3-((Ethoxy(hydroxy)phosphoryl)oxy)-2-hydroxypropyl (9Z,12Z)-octadeca-9,12-dienoate","Costunolide","N2,N4-Bis(2-methoxyethyl)-2,4-pyridinedicarboxamide","N-[2-(1H-Imidazol-4-yl)ethyl]-N'-(2-phenylethyl)thiourea","Tramadol","(2e,4e)-n-(2-methylpropyl)-6-thiophen-2-ylhexa-2,4-dienamide","Camylofine","Platyphyllonol","Diethyl L-glutamate","(4r)-4-((3s,5s,7s,9s,10s,13r,14s,17r)-3,7-dihydroxy-10,13-dimethyl-12-oxohexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid","Proscillaridin A","3-(4-Formylaminobutyryl)pyridine","N-[1,3-Dimethyl-2-oxo-6-(1-pyrrolidinyl)-2,3-dihydro-1H-benzimidazol-5-yl]-2-methoxybenzamide","Tramadol n-oxide","Oleoylserotonin","4-Piperidinepropanoic acid, .beta.-oxo-1-[(phenylmethoxy)carbonyl]-, ethyl ester","N-Arachidonoyl-L-serine","Deoxycorticosterone acetate","(4R)-4-Methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one","Erucamide","3-rha(1-2)gal(1-2)glua-soyasaponenol b","2-Naphthalenol, 1-[2-(2,4-dimethylphenyl)diazenyl]-","Imiprothrin","(2E)-3-(1H-Indol-2-yl)-2-propenoic acid","Tetracycline","3a,8-Dihydroxy-3,5a,9-trimethyl-4,5,6,7,8,9b-hexahydro-3H-naphtho[6,5-d]furan-2-one","21-Amino-3,20-dihydroxydocosan-2-yl hexopyranoside","Histamine","Gln-Met","Miltefosine","Eplerenone","Methyltyrosinate","PyroGlu-Gly-Arg","2(1H)-Pyridinone","Inulicin","Atglistatin","Leu-Leu-Lys","14,17,20-Trihydroxy-1-oxowitha-2,5,24-trienolide","7-Ethoxyresorufin","Heptadecasphing-4-enine","Acetylcitrulline","Benzyloxycarbonylglycine","Phe-Phe","Mitragynine","N,n,n-trimethyllysine","Oxycodone","N-(2-Ethyl-6-methylphenyl)hydrazinecarbothioamide","L-Leucyl-L-leucine methyl ester","Senecionine","Oleoyl 3-carbacyclic phosphatidic acid","(1E)-6-Hydroxy-12-(1H-indol-3-ylmethyl)-7-methoxy-4,13,13a-trimethyl-5,6,7,8,12,12a,13,13a,14a,14b-decahydro-3H-cycloundeca[d]oxireno[f]isoindole-9,10(4H,11H)-dione","L-Carnosine","1-acetylimidazole","Pyrrolidine","Dihydroevocarpine","Chrysophanol","1-Methoxy-N-(4-methylbenzyl)-2-propanamine","Sebuthylazine","1-(Benzoyloxy)propan-2-yl benzoate","Nicotinate","(6E)-2,10-Dihydroxy-2,6,10-trimethyldodeca-6,11-dien-3-yl .beta.-D-glucopyranoside","Imazethapyr","Ala-Glu-Lys","N-acetylhistidine","6-((E)-2-((1R,2S,3R,5S)-3,5-Dihydroxy-2-((Z)-oct-2-enyl)cyclopentyl)vinyl)tetrahydro-2H-pyran-2-one","3-Hydroxy-2-((9Z,12Z)-octadeca-9,12-dienoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate","Prostaglandin A1-biotin","Isatin","Glycodeoxycholic acid","Phe-Ala","Norvaline, 5-phosphono-","(3E)-4-Hydroxy-3-[hydroxy-[2-[(1E,3E)-6-hydroxyhepta-1,3-dienyl]-1,3,6-trimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]methylidene]-5-(hydroxymethyl)-1-methylpyrrol-2-one","4-[(Isobutylamino)methyl]benzoic acid",".beta.-D-Glucopyranosiduronic acid, 5-[3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl]pentyl"],"additional_accession":[]},"is_claimable":false,"name":"Prevention of acute graft-versus-host disease via single-dose administration of bioengineered extracellular vesicles","description":"Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for various hematological and immunologic diseases, but acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality. We previously discovered in patients and murine models that higher levels of pro-inflammatory signals before stem cell infusion are associated with the severity of aGVHD. Here, we show that extracellular vesicles (EVs) mediate the intracellular delivery of SOCS3 (suppressor of cytokine signaling 3), resulting in reduced inflammatory signaling and macrophage/dendritic cell (DC) activation. Furthermore, single-dose treatment with engineered SOCS3-loaded EVs (eEVs) significantly prevented aGVHD and increased survival in multiple murine models without compromising graft-versus-leukemia activity. Mechanistically, single-cell transcriptomics revealed that eEVs induced transcriptional features associated with an immunoregulatory milieu in recipients before allo-HSCT, and then suppressed excessive immune responses, resulting in aGVHD alleviation. In summary, delivery of SOCS3 via EVs represents a promising avenue for aGVHD prophylaxis, with great potential to improve allo-HSCT outcomes.","dates":{"publication":"2026-09-11","submission":"2026-09-11"},"accession":"MTBLS15633","cross_references":{"HMDB":["HMDB0001944","HMDB0029936","HMDB0001431","HMDB0014568","HMDB0000068","HMDB0000244","HMDB0013692","HMDB0094657","HMDB0000734","HMDB0001161","HMDB0033406","HMDB0002180","HMDB0029541","HMDB0002013","HMDB0014903","HMDB0006327","HMDB0000415","HMDB0000902","HMDB0030008","HMDB0003869","HMDB0000760","HMDB0003073","HMDB0008443","HMDB0062690","HMDB0029894","HMDB0002322","HMDB0010407","HMDB0011262","HMDB0013122","HMDB0033458","HMDB0014783","HMDB0032565","HMDB0040412","HMDB0010398","HMDB0003752","HMDB0035359","HMDB0062325","HMDB0000001","HMDB0039528","HMDB0011149","HMDB0008097","HMDB0007991","HMDB0007973","HMDB0010382","HMDB0010381","HMDB0011130","HMDB0010384","HMDB0003331","HMDB0062737","HMDB0004031","HMDB0000328","HMDB0004668","HMDB0001320","HMDB0000322","HMDB0000335","HMDB0001926","HMDB0000374","HMDB0000101","HMDB0000905","HMDB0000014","HMDB0001044","HMDB0000071","HMDB0002098","HMDB0013751","HMDB0060362","HMDB0015245","HMDB0011716","HMDB0029410","HMDB0000338","HMDB0000343","HMDB0011538","HMDB0000405","HMDB0007972","HMDB0001934","HMDB0005998","HMDB0014390","HMDB0062735","HMDB0000479","HMDB0015506","HMDB0061058","HMDB0000467","HMDB0002833","HMDB0060339","HMDB0000921","HMDB0003464","HMDB0002024","HMDB0000301","HMDB0015344","HMDB0060666","HMDB0003681","HMDB0001173","HMDB0032985","HMDB0000600","HMDB0012176","HMDB0014389","HMDB0003355","HMDB0003818","HMDB0002224","HMDB0002894","HMDB0014929","HMDB0001139","HMDB0002961","HMDB0039238","HMDB0004241","HMDB0035915","HMDB0036582","HMDB0060661","HMDB0060499","HMDB0000391","HMDB0000897","HMDB0001107","HMDB0030162","HMDB0001993","HMDB0002311","HMDB0061650","HMDB0004669","HMDB0015552","HMDB0001859","HMDB0001206","HMDB0000856","HMDB0034122","HMDB0000034","HMDB0000050","HMDB0006772","HMDB0000303","HMDB0060561","HMDB0000037","HMDB0014940","HMDB0015004","HMDB0005018","HMDB0014839","HMDB0015348","HMDB0004484","HMDB0002829","HMDB0003012","HMDB0004080","HMDB0013650","HMDB0030845","HMDB0000517","HMDB0000052","HMDB0039883","HMDB0000191","HMDB0015205","HMDB0001924","HMDB0014712","HMDB0031140","HMDB0015107","HMDB0014682","HMDB0041836","HMDB0003119","HMDB0003409","HMDB0033782","HMDB0000056","HMDB0000043","HMDB0001252","HMDB0014341","HMDB0003134","HMDB0032737","HMDB0015353","HMDB0015057","HMDB0014393","HMDB0001847","HMDB0141765","HMDB0014539","HMDB0002121","HMDB0000518","HMDB0014620","HMDB0015369","HMDB0000871","HMDB0000097","HMDB0030670","HMDB0015535","HMDB0014677","HMDB0005038","HMDB0014909","HMDB0015372","HMDB0004995","HMDB0036688","HMDB0000064","HMDB0000562","HMDB0014410","HMDB0010720","HMDB0015114","HMDB0000089","HMDB0000630","HMDB0003581","HMDB0001514","HMDB0001109","HMDB0012208","HMDB0000252","HMDB0000269","HMDB0000277","HMDB0013609","HMDB0004825","HMDB0033923","HMDB0000159","HMDB0000158","HMDB0002835","HMDB0040811","HMDB0061024","HMDB0060576","HMDB0060959","HMDB0015364","HMDB0004231","HMDB0001920","HMDB0033466","HMDB0014967","HMDB0032943","HMDB0015027","HMDB0014849","HMDB0015468","HMDB0032090","HMDB0014592","HMDB0014728","HMDB0015323","HMDB0041886","HMDB0014838","HMDB0015014","HMDB0000878","HMDB0001425","HMDB0039531","HMDB0015509","HMDB0014911","HMDB0031783","HMDB0037270","HMDB0139638","HMDB0034879","HMDB0030021","HMDB0034702","HMDB0012958","HMDB0039555","HMDB0034745","HMDB0028802","HMDB0028803","HMDB0000641","HMDB0003337","HMDB0000086","HMDB0000631","HMDB0038541","HMDB0003157","HMDB0000132","HMDB0000133","HMDB0030311","HMDB0000756","HMDB0015444","HMDB0032323","HMDB0001296","HMDB0060263","HMDB0000063","HMDB0014472","HMDB0015549","HMDB0061115","HMDB0000157","HMDB0014453","HMDB0034913","HMDB0000738","HMDB0002096","HMDB0014900","HMDB0061933","HMDB0015197","HMDB0000688","HMDB0015705","HMDB0032797","HMDB0015303","HMDB0015341","HMDB0000062","HMDB0000033","HMDB0000904","HMDB0000670","HMDB0000679","HMDB0004224","HMDB0000696","HMDB0013716","HMDB0062514","HMDB0011175","HMDB0006566","HMDB0014736","HMDB0014792","HMDB0013243","HMDB0000687","HMDB0002304","HMDB0014647","HMDB0014986","HMDB0001929","HMDB0014992","HMDB0006568","HMDB0033699","HMDB0015564","HMDB0014739","HMDB0012252","HMDB0004385","HMDB0000698","HMDB0015539","HMDB0014372","HMDB0003405","HMDB0030318","HMDB0060627","HMDB0001262","HMDB0015294","HMDB0014922","HMDB0001389","HMDB0014597","HMDB0031802","HMDB0015654","HMDB0002085","HMDB0011754","HMDB0014497","HMDB0029217","HMDB0015363","HMDB0014665","HMDB0041933","HMDB0002056","HMDB0014440","HMDB0031581","HMDB0041938","HMDB0003254","HMDB0005066","HMDB0011727","HMDB0013645","HMDB0001325","HMDB0060757","HMDB0004969","HMDB0015253","HMDB0004620","HMDB0003357","HMDB0001129","HMDB0000212","HMDB0011756","HMDB0013253","HMDB0015299","HMDB0003633","HMDB0060900","HMDB0004949","HMDB0000215","HMDB0014748","HMDB0060268","HMDB0000446","HMDB0002038","HMDB0002099","HMDB0060288","HMDB0013409","HMDB0001539","HMDB0014982","HMDB0014917","HMDB0029523","HMDB0038482","HMDB0015129","HMDB0001406","HMDB0000855","HMDB0001488","HMDB0015247","HMDB0014723","HMDB0060657","HMDB0060538","HMDB0014325","HMDB0041959","HMDB0015296","HMDB0005012","HMDB0005765","HMDB0015304","HMDB0014759","HMDB0014640","HMDB0002100","HMDB0000222","HMDB0013035","HMDB0014790","HMDB0014457","HMDB0014692","HMDB0014928","HMDB0028998","HMDB0013302","HMDB0060276","HMDB0004610","HMDB0015095","HMDB0015264","HMDB0030185","HMDB0030339","HMDB0015310","HMDB0031344","HMDB0015191","HMDB0015219","HMDB0006695","HMDB0014859","HMDB0001830","HMDB0029010","HMDB0014564","HMDB0015313","HMDB0001849","HMDB0005102","HMDB0013629","HMDB0003034","HMDB0000241","HMDB0014488","HMDB0000648","HMDB0130987","HMDB0001366","HMDB0000926","HMDB0001545","HMDB0000239","HMDB0037113","HMDB0031641","HMDB0014611","HMDB0005026","HMDB0014388","HMDB0015048","HMDB0041782","HMDB0031786","HMDB0037115","HMDB0030666","HMDB0001185","HMDB0042012","HMDB0060761","HMDB0039526","HMDB0035293","HMDB0000259","HMDB0029887","HMDB0034649","HMDB0015055","HMDB0014565","HMDB0004827","HMDB0000848","HMDB0015568","HMDB0000953","HMDB0000258","HMDB0000036","HMDB0036074","HMDB0014396","HMDB0015592","HMDB0014897","HMDB0094708","HMDB0037942","HMDB0000235","HMDB0002666","HMDB0014517","HMDB0035030","HMDB0014339","HMDB0032538","HMDB0034263","HMDB0014969","HMDB0000875","HMDB0000601","HMDB0001457","HMDB0015240","HMDB0014583","HMDB0000925","HMDB0240288","HMDB0014947","HMDB0005768","HMDB0000306","HMDB0000044","HMDB0003555","HMDB0036130","HMDB0030020","HMDB0037479","HMDB0000299","HMDB0015464","HMDB0014698","HMDB0031752","HMDB0005023","HMDB0006285","HMDB0002035","HMDB0014447","HMDB0000954","HMDB0012204","HMDB0000735"]}}