MetaboLights

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ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/m_MTBLS15633_LC-MS_alternating_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/s_MTBLS15633.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/a_MTBLS15633_LC-MS_alternating_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/S4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/G2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/B3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/G4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/S3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/B2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/G6.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/B5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/S6.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/S1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/G1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/S2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/B1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/G5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/S5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/G3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/B4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633/FILES/RAW_FILES/B6.rawprimary200OKftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15633Taxonomic annotation was performed against the Silva database (v138) using q2-feature-classifier.MetaboLightsPublicLiquid Chromatography MS - alternating - hilicUHPLC-MS/MS Conditions: Metabolites were separated on a Vanquish UHPLC system using an ACQUITY UPLC BEH Amide column (Waters) and analyzed on an Orbitrap Exploris 480 mass spectrometer (Thermo Fisher) in positive/negative DDA modes.Prevention of acute graft-versus-host disease via single-dose administration of bioengineered extracellular vesicles.University of Science and Technology of ChinaXinye Zhangfecesmass spectrometry assaySample Preparation & QC: Fecal samples were homogenized and extracted with cold methanol/acetonitrile (1:1, v/v), dried, and reconstituted in acetonitrile/water (1:1, v/v); pooled quality control (QC) samples were injected periodically to assess instrument stability.Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS15633Cheng Linzhao. University of Science and Technology of China. lzcheng@ustc.edu.cn.Xinye Zhang. University of Science and Technology of China. jojozhangxy@gmail.com.Liu Senquan. University of Science and Technology of China. liusenquan1988@ustc.edu.cn.Raw reads were trimmed using Cutadapt, and subsequent quality filtering, denoising, and chimera removal were executed via the DADA2 plugin within QIIME2 (v2020.11) to generate the amplicon sequence variant (ASV) abundance table.Treatmentjojozhangxy@gmail.comSample Collection & Storage: BALB/c mice were divided into BM, BM+T, and BM+T+eEVs groups to establish an aGVHD model. On day 14 post-transplantation, colonic fecal samples (~80 mg) were collected, snap-frozen in liquid nitrogen, and stored at -80°C.MetabolomicsThermo Scientific Vanquish UHPLC SystemEVSOCS3MetabolomicsMus musculusThermo Scientific Orbitrap Exploris 240untargeted analysisfecesgraft versus host diseaseThermo Scientific Vanquish UHPLC SystemEVSOCS3MetabolomicsMus musculusThermo Scientific Orbitrap Exploris 240untargeted analysisfecesgraft versus host diseaseData Processing & Statistics: Raw files were processed using XCMS for peak picking and alignment; differential metabolites were identified based on VIP > 1.0 from OPLS-DA and FDR < 0.05Resveratrol 3-O-D-glucuronideIle-ThrL-Tyrosine tert-butyl esterStaurosporineCholest-5-ene-3b,20,22R-triolN-[(4-Nitrophenyl)methyl]benzamide(Z,E)-Tetradeca-9,12-dienolSer-Thr(2S)-2,6-diaminohexanamideMethyl linolenateMephosfolanD-erythro-N-stearoylsphingosinePhe-IlePopulinN-OxyclozapineStrevertene A(1.beta.,3.beta.,8.xi.,9.xi.,14.xi.)-3-((6-Deoxy-.alpha.-L-mannopyranosyl)oxy)spirosta-5,25(27)-dien-1-yl 6-deoxy-2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-galactopyranosideCycloateAsn-Arg-LysVal-MetPantothenolOxeladinSteganacinNormorphineTimololPanobinostatMontanin DSethoxydimAzepane-1-carboxylic acid (4-chlorophenyl)amideBifenazate(4r)-4-((3r,5s,7r,9s,10s,13r,14s,15r,17r)-3,7,15-trihydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acidDye X-5380-16 Cation3.beta.-Tetrahydrocortisol, 3,21-diacetateN-Hexanoylsphingosine1-(1Z-Octadecenyl)-sn-glycero-3-phosphocholineImazapyrGlu-Thr-ArgThr-Val-Arg0Gly-Gly-Leu4''-trans-HydroxycilostazolD-PsicoseHyocholic acid4-Methoxypyridine-2-carboxamideD-Glucosaminic acidTrp-Gly-Trp9Z,11E,13E-Octadecatrienoic acidAcridine Orange2-Acetamido-3-(4-hydroxy-3-methoxyphenyl)propanoic acid[(2r,3s,4s,5r,6r)-6-[1,7-bis(4-hydroxyphenyl)-5-oxoheptan-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl (e)-3-(3,4-dimethoxyphenyl)prop-2-enoateBenzyldimethyltetradecylammonium cation2-Ethylhexyl diphenyl phosphateKoninginin D6-Bromo-4-(piperazin-1-yl)quinazoline9-Hydroperoxy-10E,12Z,15Z-octadecatrienoic acidTyr-IleSimeconazole(3E)-4-(2,4,6-Trimethyl-3-cyclohexen-1-yl)-3-buten-2-oneN-Benzyl(1-naphthyl)methanamineCimicifugoside H 2.alpha.-Guanidinoglutaric acidPilocarpineN-Cyclohexyl-N'-(1-naphthyl)ureaSelfotel2-(3-Fluorophenyl)benzonitrile12-Ketodeoxycholic acidIle-Met-LysArginineBisphenol A diglycidyl etherEurycomalactoneN-1-Adamantylquinoline-2-carboxamide3-Cyano-N-(2,5-diphenylpyrazol-3-yl)benzamide2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, (2E)-Asn-Ile-ArgRacemoramideTriethyl citrate3-(3-Fluorobenzyl)piperidinePro-GlnAminorexAzocyclotinBeta-alanineLeu-Ala-Arg6-Fluoro-3-(4-piperidinyl)-1H-indoleTetrabenazineRoquefortine aCarbetamide.beta.-Estradiol 3-benzoateN,N-Dimethyl-2,2-diphenylethanamine7-(2-Aminophenyl)heptanoic acidHexylglutathioneN6-MethyladenineDioscinMethylergonovineIle-Trp-Lys1-Pyrrolidineheptanoic acid, 2-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-yn-1-yl]-5-oxo-, (2R)-Pro-Glu3-(4-Hydroxy-2,2-dimethyl-1-oxo-3,3a-dihydroimidazo[1,2-a]indol-4-yl)-2-(4-oxoquinazolin-3-yl)propanoic acidMoxonidineN-(Deshydroxyethyl)dasatinibPantothenic acid3-(6-Amino-9H-purin-9-yl)-1,2-propanediol2-(Cyclohexylamino)benzoic acidN-DesethylsunitinibYohimbineMan1FProstaglandin E2 serinolamide6-Benzylaminopurine(2r,3s,4s,5r,6r)-2-[[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[4-(4-hydroxyphenyl)butan-2-yloxy]oxane-3,4,5-triolGlutamylphenylalanineTetrahydrocortisol 21-acetate(-)-.alpha.-Kainic acidDilinolenin (9c,12c,15c)Echinocystic acid 3-glucosideTaprostene (free acid)Thr-Met17.alpha.-EthynylestradiolPirimicarb-desamidoTropicamide15-Ketoprostaglandin E1FucosterolMetalaxylAzelastine.beta.-Nicotinamide adenine dinucleotideDiflufenzopyrAla-TrpMonoisobutyl phthalateCloquintocet-mexyl1,2-dioleoyl-sn-glycero-3-phosphatidylcholine2-(1,3-Benzothiazol-2-ylthio)acetohydrazide(2-oxo-2,3-dihydro-1h-indol-3-yl)acetic acidRucaparibVal-Asp-LysProstaglandin D1ProlylalanineProstaglandin D3Dienestrol diacetateBenzyl alcoholTetramethylammonium cationRutinoseLinoleoylglycine3-[(2s,3r,4s,5s,6r)-6-[[(2r,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]oxy-2-methylpyran-4-onePyridineAla-AlaDigitoxinHexanoyl-L-carnitine7.alpha.,12.alpha.-Dihydroxycholest-4-en-3-one1-O-((3.beta.,5.Xi.,9.Xi.)-3-((3-O-.beta.-D-Glucopyranosyl-D-glucopyranosyl)oxy)-28-oxoolean-12-en-28-yl)-.beta.-D-glucopyranoseAsp-Leu-ArgChenodeoxycholic acidAzamethiphosEmetamineLeukotriene B4 3-aminopropylamideAuranticin A11.beta.-HydroxyprogesteroneAndrosterone glucuronideIndoleTepraloxydimAdaphostinArg-ProLovastatinMet-Val-LysDextromethorphanLeu-Ile-ArgWithanoside VI1,3,4,6,7,8-Hexahydro-2H-pyrimido[1,2-a]pyrimidineDiazinon[(4S,6R,6aS,9R,10S)-6,10-Diacetyloxy-6a,9-dihydroxy-3-(methoxymethyl)-6,9-dimethyl-2-oxo-5,7,8,10-tetrahydro-4H-benzo[h][1]benzofuran-4-yl] 2-methylprop-2-enoateFumonisin b1Phe-Val-LysIbutilide4-(2-Fluorophenyl)-3,4-dihydro-1(2H)-naphthalenoneL-CarnitineO-t-Butyl-L-threonine methyl ester5-trans-Prostaglandin F2.alpha.1H-Indole-1-pentanoic acid, 3-[(4-methoxy-1-naphthalenyl)carbonyl]-Leu-Asp-ArgN-[5-[(5-tert-Butyloxazol-2-yl)methylthio]thiazol-2-yl]isonipecotamide(3.beta.,8.xi.,9.xi.,14.xi.,17Z)-3-((2-O-(6-Deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl)oxy)-16,22-dioxocholesta-5,17-dien-27-yl .beta.-D-glucopyranosideAminoalbendazole sulfoneCyclopentolate1-Oleoyl-2-palmitoyl-rac-glycerolEstrone sulfateAdenosineN-(4-Methoxyphenyl)-2-(1-piperazinyl)acetamideEtoposideScopolamine .beta.-D-glucuronideCytidine, 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-, 2',3'-diacetate2-HydroxyestradiolPhilanthotoxin 74Pro-IlePterostilbeneRostafuroxinNakijiquinone hNeolinustatinOligomycin BCyclopropylacetic acidOligomycin AMyristoyl ethanolamideLobelanidineBenazeprilMethyl 3,16-dihydroxy-4,4,8,12,16-pentamethyl-15,17-dioxoandrost-11-ene-14-carboxylateN-(3-Chloro-2-methylphenyl)-1-cyclohexyl-5-oxopyrrolidine-3-carboxamidegamma-L-Glutamyl-L-valineL-BunololIsodeoxyelephantopin2-Thiophenecarboxamide, N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-1-O-Hexadecyl-2-O-methyl-sn-glyceryl-3-phosphorylcholine(1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinolin-3-yl)methanolMelatonin2-{2-[2-(Methacryloyloxy)ethoxy]ethoxy}ethyl 2-methylacrylate5-MethylcytosineN-Butyryl-L-homoserine lactonePro-Tyr-LysSisomicinFenpropathrinIsoproterenolN-Acetyl-D-galactosamineClomipramine2-Phenylbenzene-1-sulfonamideOleyloxyethylphosphorylcholineD-tryptophanN-.alpha.-(tert-Butoxycarbonyl)-L-histidine9-Benzyl-9-azabicyclo[3.3.1]nonan-3-one1-Pentyl-3-(4-methoxynaphthoyl)indoleLovatatinSphingosine2-Butenoic acid, 7-(acetyloxy)-3,6,7,8,9,10-hexahydro-6-hydroxy-2-methyl-10-oxo-2H-oxecin-3-yl esterN-Palmitoyl-D-sphingosine2-Furanacetic acid, tetrahydro-5-(2-hydroxybutyl)-.alpha.-methyl-, 1-[[5-(1-carboxyethyl)tetrahydro-2-furanyl]methyl]propyl ester6-(Difluoromethoxy)-3-pyridinamineValerylfentanyl4-Hydroxy-1,5-dimethyl-1,2-dihydropyrimidin-2-oneIle-Ile17,20-Dimethylprostaglandin F1.alpha.1-O-((3.beta.,5.Xi.,9.Xi.,18.Xi.)-3-(.beta.-D-Glucopyranuronosyloxy)-23-hydroxy-28-oxoolean-12-en-28-yl)-.beta.-D-glucopyranose1-Stearoyl-2-hydroxy-sn-glycero-3-phosphoethanolamineNaphtho[2,1-b]furan-4,5-diol, dodecahydro-2-(1-hydroxy-1-methyl-2-propen-1-yl)-3a,6,6,9a-tetramethyl-1-(2-Allylphenoxy)-3-(4-morpholinyl)-2-propanol2-(Diphenylamino)benzoic acid6-(Methylthio)guanineTetrahydroharman-3-carboxylic acid1-O-(1,3,25-Trihydroxy-28-oxo-20,24-epoxy-9,19-cyclolanostan-28-yl)hexopyranosePsychosine9-Oxo-10E,12Z-octadecadienoic acidBuprenorphineLysineAcetaminophen1-Ethyl-N4,N5-dimethyl-1H-imidazole-4,5-dicarboxamideSclareolideHeptaminol5-NitroisophthalamideCabergoline1-Oleoyl-2-myristoyl-sn-glycero-3-phosphocholineHexobarbitalDidecyl hydrogen phosphateOleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-6-(2,3-Dihydroxy-3-methylbutoxy)-4-methoxy-5-methyl-2,3-dihydroisoindol-1-one3-Propyl-1H-pyrazole-5-carboxylic acidGuanineMeperidineSuberoylanilide hydroxamic acidTrihydroxycholestanoic acid(-)-Neplanocin ANigellineN,2-Dimethyl-N-phenylbutanamideChloramphenicol succinate(2Z)-((4R,5S,6S)-6-(.beta.-D-Glucopyranosyloxy)-4,5-dihydroxycyclohex-2-en-1-ylidene)acetonitrileDehydrocostus lactoneFructoselysinePutative analog of trichodinaThr-Leu-ArgN-Acetyl-DL-leucineAmpiroxicamIprovalicarb1-methyladenosineXanthosine(3.beta.,5.Xi.,9.Xi.,18.Xi.,22.beta.)-22-Hydroxy-25-oxoolean-12-en-3-yl 6-deoxy-.alpha.-L-mannopyranosyl-(1->2)-.beta.-D-xylopyranosyl-(1->2)-.beta.-D-glucopyranosiduronic acidN-.alpha.-Acetyl-L-arginineMyriocin2-(Methylamino)-1-(morpholin-4-yl)ethan-1-oneTebufenpyrad7-MethylguanineNorcodeineGln-Thr-LysFenamidoneTris(hydroxymethyl)aminomethaneTerpestacin1-(4-Nitrophenyl)azepaneN-acetylputrescineVeratramine2'-Fucosyllactose7.alpha.,12.alpha.-Dihydroxy-5.beta.-cholestan-3-oneRanolazine1H-Benzimidazole-2-butanoic acid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, ethyl esterN,N-Dimethylhistidine1-O-((2.beta.,3.beta.,5.Xi.,9.Xi.,18.Xi.)-3-(.beta.-D-Glucopyranuronosyloxy)-2,23-dihydroxy-28-oxoolean-12-en-28-yl)-.beta.-D-glucopyranoseLys-ProStrophanthidol(3-Carboxypropyl)trimethylammonium cationAla-Pro1-(Diphenylacetyl)piperazineN,N-Dimethyldodecylamine N-oxidePioglitazoneDL-OrnithineN-.alpha.-(tert-Butoxycarbonyl)-L-prolineAdrenosteroneMet-PheN-Methyl-L-asparagineDL-isoleucineCarnitine9-Allyl-2-phenyl-9H-imidazo[1,2-a]benzimidazolePro-ThrVulgarinCreatine, ethyl esterSebacic acid bis(N-succinimidyl) esterZolpidemL-Valine, N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-, methyl ester4-Bromo-2-{[(1-propyl-1H-benzimidazol-2-yl)amino]methyl}phenol5-(Furan-3-yl)-2a',5'-dihydroxy-8b'-(hydroxymethyl)-7'-methyldodecahydrospiro[furan-3,6'-naphtho[1,8-bc]furan]-2-oneNorethindrone 2,3,4-tri-O-acetyl-.beta.-D-glucuronide methyl ester2,3,16,20,25-Pentahydroxycucurbita-5-ene-11,22-dione-3-O-glucosideTrimethylamine N-oxideBazedoxifeneN2-Acetyl-N-(2-(4-hydroxyphenyl)ethyl)-.alpha.-glutamine5-(Galactosylhydroxy)-L-lysine2-Hydroxy-6-methylpyridine-4-carboxylic acid[9-[(E)-3-Acetyloxy-4-methylhex-4-en-2-yl]-12-hydroxy-3-(2-hydroxypropan-2-yl)-10-methoxy-6a,12b-dimethyl-8,11-dioxo-1,2,3,4a,5,6,12,12a-octahydropyrano[3,2-a]xanthen-1-yl] acetate1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholineD-erythro-Sphingosine-1-phosphateAcetyl coenzyme ABerberine cation3-Allyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol2-[(1-Methyl-1H-tetraazol-5-yl)sulfanyl]-N-(2-phenylethyl)acetamide9-Benzyl-5-[(furan-2-ylmethyl)amino]-7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitriletert-Butyl 4-(2-aminoethyl)-1-piperazinecarboxylateLithocholylglycine(-)-SecoisolariciresinolBiocytinOfloxacinHis-Glu-Arg(24E)-12,15-Dihydroxy-3-(pentopyranosyloxy)-9,19-cyclolanost-24-en-26-oic acidTrifluoroperazineBisoxireno[4,5:8,9]cyclodeca[1,2-b]furan-4(1aH)-one, 2,2a,6,6a,7a,8,9,9a-octahydro-1a,5,7a-trimethyl-Goshonoside F5ArthrobactinTebuconazolErgocristine1H-Indazole-3-carboxamide, N-1-naphthalenyl-1-pentyl-ArchangelicinEpothilone BPimecrolimusCyclo(prolyltyrosyl)Mahanimbine5-Methyl-4-phenyl-o-anisidineZinniol2,2'-(2-Hydroxyethylazanediyl)diacetic acid(5-benzoyloxy-4,6-dihydroxy-3-methoxycyclohexen-1-yl)methyl benzoate6-Amino-1-benzyluracil[4-Anilino-2-(4-fluorophenyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrol-3-yl]acetic acid4-Fluoro-.alpha.-pyrrolidinobutiophenoneGly-Ile-Lys3-(.alpha.-L-Arabinofuranosyloxy)pimara-8(14),15-dien-12-yl 6-deoxy-.beta.-D-galactopyranoside2-Aminophenol16-Phenoxyprostaglandin F2.alpha. ethylamideEprosartanN-Arachidonoyl-L-alanine3-Hydroxymethylmefenamic acidLinearized pseudacyclin aValine conjugated chenodeoxycholic acid4,4'-Oxydibenzene-1,2-diamineVerruculogenPyridoxalTrigonelline7-methyl-3-methylidene-6-(3-oxobutyl)-4,7,8,8a-tetrahydro-3ah-cyclohepta[b]furan-2-one3H-Benzimidazol-5-yl-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amineNCGC00161382-012-Oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine(3E)-10b-(2-Methylbut-3-en-2-yl)-3-((5-(2-methylbut-3-en-2-yl)-1H-imidazol-4-yl)methylidene)-6,10b,11,11a-tetrahydro-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione5-Methoxy-4-methyl-2,4-dihydro-3H-1,2,4-triazol-3-oneBetaine aldehyde cationo-TolidineDanazol1-Acetamidocyclopentane-1-carboxylic acidSchizandrol1-Naphthalenecarboxylic acid, 1,2,4a,5,6,7,8,8a-octahydro-2-(2-hydroxybutyl)-1,3-dimethyl-, [1R-[1.alpha.,2.beta.(R),4a.alpha.,8a.alpha.]]-(-)-AtropineProstaglandin E1 ethanolamideL-Hydroxyarginine7-Methylguanosine28-Hydroxy-28-oxoolean-12-en-3-yl 6-deoxyhexopyranosyl-(1->3)hexopyranosyl-(1->2)hexopyranosiduronic acidMethanone, [1-(5-hydroxypentyl)-1H-indol-3-yl](4-methoxy-1-naphthalenyl)-2-(4-morpholinyl)benzothiazole1,4,10-Trioxa-7,13-diazacyclopentadecane, 7,13-bis[(4-nitrophenyl)methyl]-1-Stearoyl-2-arachidonyl-sn-glycero-3-phosphocholine8-Geranyl-7-hydroxycoumarinBromobutideMethanone, [1-(2-hydroxypentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-Tetradecylphosphonate1-Palmitoyl-2-linoleoyl-rac-glycerolN6-me-daAspidocarpine1-O-octyl-2-O-(N-methylcarbamoyl)-sn-glyceryl-3-phosphorylcholine15-Deoxy-.DELTA.12,14-prostaglandin J2 biotinamide2-Oxiraneoctanoic acid, .eta.-hydroxy-3-octyl-17alpha-hydroxyprogesterone1,3-Propanediol, 2-amino-2-[2-[4-[[6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexyl]oxy]phenyl]ethyl]-Arg-Leu-ArgVal-IleIle-Gly-IleDinor-12-oxophytodienoic acid5-(3-Pyridinyl)-1,3,4-thiadiazole-2-thiolTriethanolamine3,4-Dimethylbenzaldehyde22-(Acetyloxy)-16-hydroxyolean-12-en-3-yl 2-O-hexopyranosylhexopyranosiduronic acidN-DesmethylzolmitriptanTetraethylammonium cation4-Androstene-11.beta.,17.beta.-diol-3-oneWithaferin ANeohesperidosePhenylalanineBohemineSorbitan monopalmitateLycorineLatanoprostNifedipine2-MethoxyestradiolScropolioside dMorpholine5'-Fluoro-2'-hydroxy-4-methylchalconeAlpha-codeimethineSer-ArgTenuazonic acidMethyl L-pyroglutamatePentaethylene glycolMevastatinN-(Dodecanoyl)-1-.beta.-glucosyl-sphing-4-enine3-Phenylazopyridine-2,6-diamineHarringtonineN,N-Bis(2-hydroxyethyl)glycineTrifloxystrobinSarafloxacinAmprenavir1-O-Hexadecyl-2-deoxy-2-thio-R-(heptanoyl)-sn-glyceryl-3-phosphocholine1-Hexadecyl-sn-glycero-3-phosphocholineD-erythro-Sphinganine2-Amino-2-methyl-1-propanolTryptamineCrotonic acidChlorprothixeneGln-Phe-ArgAmisulprideMorphine1-Deoxy-1-(methylamino)-D-galactitolPromazineCreatine2-Hydroxy-4,6-dimethylpyrimidineOxandroloneDiisodecyl phthalate4'-Deoxyprovincialin7-Keto-3.alpha.,12-.alpha.-dihydroxycholanic acidTazettinePro-AlaCytosineThiamine cationDimepiperatePyroGlu-Gln-ArgN-Benzyl-1-methyl-1H-tetraazol-5-amine(3E)-4-(1-Methyl-1H-indol-3-yl)-3-buten-2-oneGuanidinosuccinic acidArachidonoylserinol(3R)-5-(2-Fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-methyl-3H-1,4-benzodiazepin-2-oneMet-ArgTyr-ArgHirsuteineD-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-4-Bromoindole(6E)-Heptadeca-6,16-diene-1,2,4-triolSulfanilate(+) Biotinyl-6-aminohexanoic acidBenzoylnorecgonine.gamma.-Muricholic acid4-Methyl-1H-pyrazoleD-Glucosamine 1-phosphateHypaphorine1-(4-Methoxybenzyl)-4-piperidinylamine5-[4-(Isopentyloxy)phenyl]-5-methyl-2,4-imidazolidinedioneN-Hexanoyl-L-homoserine lactone(.+,-.)-2-Methylarachidonoyl-2'-fluoroethylamideCyclo(proline-leucine)(5-Benzoyloxy-1,2,6-trihydroxycyclohex-3-en-1-yl)methyl benzoate2-Acetyl-3-ethylpyrazine2,8,9-Trimethyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane6-Methyl-5-hepten-2-one3-(5-hydroxy-2,2,7,8-tetramethyl-6-oxo-7,8-dihydropyrano[3,2-g]chromen-10-yl)hexanoic acidCaffeoyl alcoholCilastatinTrp-AlaAla-Ser-LysDi-dihydrocaffeoyl spermidine(3r,7r,9s,10s,12s,13r,14s,17r)-17-((2r)-6,7-dihydroxy-6-methylheptan-2-yl)-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthrene-3,7,12-triol2,4-Dimethylnicotinic acidDi-p-coumaroylputrescineArg-Gln-ArgBenzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-RepaglinideHirsutine4-(Thiophen-2-yl)benzene-1,2-diaminePyridabenSyringolin CTyr-Leu5-Amino-2-(3,4'-dihydroxy-4,4,7,8a-tetramethyl-6'-oxospiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-3,8-dihydrofuro[2,3-e]isoindole]-7'-yl)-5-oxopentanoic acidPro-TrpBimatoprost amideHeptaethylene glycol p-tert-octylphenyl etherGlutamine1,2-Dimethylimidazole(R)-ButyrylcarnitineGly-Pro-Arg-Pro-amidePeramivir2-[4-(Propan-2-yloxy)phenyl]quinoline-4-carboxylic acidN-Cyclohexyl-N'-(1,2,3,4-tetrahydro-1-naphthalenyl)urea1-Hexadecyl lysophosphatidic acid2,5,7-Trimethyl-4(1H)-quinolinone5-Aminosalicylic acid(2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid9Z-Octadecenoic acid, (2S)-3-[(hydroxymercaptophosphinyl)oxy]-2-methoxypropyl esterVitamin C3-DodecyloxypropylamineDesmethylolanzapine12-cytisineacetamideTyramine2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[3-(triazol-2-yl)anilino]pyrimidine-5-carboxamide20-HETEAtenolol-desisopropyl(2E,4E,10Z)-N-(2-Methylpropyl)hexadeca-2,4,10-trienamideL-Citrulline4-acetamidobutanoateRutamarinEthyl 2-(3-chloropyridin-2-yl)-5-oxopyrazolidine-3-carboxylate1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine4-Imidazoleacrylic acid2,4-Diphenylbutanoic acidSer-AlaNalidixic acidIle-Gln-Arg1,5-Hexadien-3-ol[3-Nitro-4-(1-piperidinyl)phenyl](phenyl)methanoneDL-OctopamineFeruloyl putrescine (isomer of 1178)Withanolide B4-ohe1-1-n3adeThr-Lys-LysGlycerophosphocholine[(2r,3r,4s,5s,6r)-3-acetyloxy-2-(acetyloxymethyl)-5-hexanoyloxy-6-[(2s,3r)-2,3,4-trihydroxybutoxy]oxan-4-yl] tetradecanoateSenkirkin1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanoneDL-phenylalanineFluprostenol serinolamide3-Acetyl-7-diethylaminocoumarinFenamiphos sulfoneDesmethylcitalopramN-(2,3-Dimethoxybenzyl)-1,2,3,4-tetrahydro-1-naphthalenamineNG,NG-Dimethyl-L-arginineDeoxypeganineTrilostane2-(Aminomethyl)-4-methylpentanoic acidTyr-Pro1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-.alpha.,.alpha.- dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acidPropanedioic acid, 2-(2-methylpropyl)-, 1,3-dimethyl esterDipivefrineMethyl 4-hydroxy-3,5-dimethoxybenzoate2-([1,1'-Biphenyl]-4-yloxy)ethylamine1-Dodecyl-2-pyrrolidinoneNizatidineCycloxydimeN-(4-Chlorobenzoyl)-3-(4-methoxyphenyl)-.beta.-alanineCinobufotalinProstaglandin D2 ethanolamideDiethylcarbamazine1H-Indole-3-carboxamide, N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-(5-hydroxypentyl)-Arg-LeuBergamotinFlurprimidolBenzamide, N-[2-(dimethylamino)ethyl]-N-methyl-4-[[[[4-[4-(4-morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]amino]carbonyl]amino]-(2S,3S)-3-Hydroxyleucine7-Hydroxy-10-(2-hydroxypropan-2-yl)-2,2a,4,7b,13a-pentamethyl-6-oxo-2a,3,4,6,7,7a,7b,8,9,10,11a,12,13,13a-tetradecahydro-2H-oxeto[2',3':1,5]cyclopenta[1,2-h]pyrano[3,2-a]xanthene-3,8-diyl diacetateMethacholine cation5-Aminovaleric acidGlu-Gly-Arg5-(2-Thienyl)-1,3,4-oxadiazole-2(3H)-thione3,6-Dimethylbenzene-1,2-diamine4-Acetyloxy-8-(3-oxo-2-pent-2-enylcyclopenten-1-yl)octanoic acid6-Ketoprostaglandin E1N-(Phenylacetyl)ureaTyr-Tyr1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineD-Glucosamine7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin8-Hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]-2(1H)-quinolinoneHis-LeuVal-ThrAsn-Gly-Arg(+)-Muscarine cationTrp-ProN-[(1E)-2-(4-Nitrophenyl)-1-azavinyl]-2-(2-naphthylamino)acetamideN-(Methylsulfonyl)-13-(3-pentyloxiranyl)-5Z,8Z,11Z-tridecatrienamideArg-Phe(3,8-Dihydroxy-6,9-dimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-3-yl)methyl acetateTabersonineAldosterone1,2,3,6-TetrahydrobenzylalcoholHomatropine(3aR,4S,6E,9Z,11aS)-4-Hydroxy-6,10-dimethyl-3-methylidene-2,8-dioxo-2,3,3a,4,5,8,11,11a-octahydrocyclodeca[b]furan-11-yl (2Z)-2-methylbut-2-enoateAdenylyl(3'-5')cytidineIndolineAnilineL-Tyrosine, ethyl ester5.beta.-Pregnane-3.alpha.,17-diol-20-oneLeukotriene B4 ethanolamideN-Benzyl(2-methoxyphenyl)methanamineVal-Val-ArgN-(sec-Butyl)-N-(4-(sec-butyl(trifluoroacetyl)amino)phenyl-2,2,2-trifluoroacetamideGelsemineAntibiotic F 1839A3-[8-(2-Hydroxypropan-2-yl)-3-methoxycarbonyl-3,4a,7,10a-tetramethyl-5-methylidene-1,4-dioxo-6,6a,8,9,10,10b-hexahydrobenzo[h]isochromen-7-yl]propanoic acidIvabradineN-Phenylacetyl-L-prolylglycine ethyl esterGlufosinate2-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]ethylaminePalmitoylcarnitineChlormadinone acetateCorydalineScropolioside BPencycuron2-Ethyl-2-phenylmalonamideIndole-3-butyric acidEchimidinePalmitoyl-L-carnitine2,3,14,20,22,25,26-Heptahydroxyergost-7-en-6-one(.+,-.)-N,N-Dimethyl-3,4-methylenedioxyamphetamineProcaineMildronateProtoporphyrin IXHeptadecasphinganine2'-DeoxyadenosineEszopiclone N-oxideAsn-AsnThr-ProThiamet GArg-TrpMeOSuc-Ala-Ala-Pro-Val-AMCNalorphineVitamin k1LeucineOleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester[(4,6-Dimethyl-2-pyrimidinyl)amino]acetic acid3-HydroxybutyrylcarnitineNordazepam5-Methyl-2'-deoxycytidineCitalopram3-Hydroxy-6-[[(E)-3-hydroxy-2,4-dimethylhept-4-enoyl]amino]-2,4-dimethyl-5-oxohexanoic acidAla-Gly-ArgDesferrioxamine d2Val-Gln3,4-Bis(benzyloxy)benzaldehyde3-Fluoro-7-methylimidazo[1,2-a]pyridine-2-carboxylic acid1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole1-(2,2,2-Trifluoroethyl)-4-piperidinylamine3-Amino-2,3-dihydrobenzoic acid1-Palmitoyl-sn-glycero-3-phosphocholineEthoxyquinN-acetylglucosaminePro-ProAtazanavir2-Hydroxy-3-methoxybenzenemethanolPerifosine3-Oxo-4-cholestenoic acidTrp-Arg-ArgGalacto-N-bioseD-erythro-Imidazolylglycerol phosphatep-Coumaric acidArg-Ala-LysN1-Benzyl-N2,N2-diethyl-1,2-ethanediamine5,10-Dihydro-10-phenophosphazinol 10-oxide1H-Indole-3-methanamine, 5-(2-amino-5-pyrimidinyl)-N,N-diethyl-1-octyl-1-Piperidinecarboxamide, N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-16-OxoandrostenediolIrinotecan1,6-Dioxacyclohexadecane-7,16-dione2-Acetamido-2-deoxy-3-O-(.beta.-D-galactopyranosyl)-D-glucopyranose3,11,20-Trihydroxypregn-8-ene-4-carboxylic acidMet-Ala-Lys2-(4-Pyridinyl)-2,3-dihydro-1H-perimidineLevorphanolProstaglandin F2.alpha. serinolamide4-Amino-5-(1H-benzimidazol-1-ylmethyl)-4H-1,2,4-triazole-3-thiol(Methylenecyclopropyl)acetyl-L-carnitineDoxazosin3-Hydroxy-2',4,4',6'-tetramethoxychalconeOlanzapineBenzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-1-O-Octadecyl-sn-glyceryl-3-phosphorylcholineN-((7E,11Z)-6,13,14-Trihydroxy-3-(1H-indol-3-ylmethyl)-4,5,10,12-tetramethyl-1,17-dioxo-2,3,3a,6,6a,9,10,13,14,15,16,17-dodecahydro-1H-cyclotrideca[d]isoindol-15-yl)acetamideSchizandrin ASchizandrin B1H-Indazole-3-carboxamide, N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-pentyl-(E)-4-[4-[(E)-Hept-1-enyl]-2,5-dihydroxy-3-(hydroxymethyl)-7-oxabicyclo[4.1.0]hept-3-en-6-yl]-2-methylbut-2-enoic acidStearoylcarnitineHelicin5-Aminopentanamide(1s,2r,4as,6ar,6br,10s,12ar,14bs)-1,2,6b,9,9,12a-hexamethyl-10-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1h-picene-4a,6a-dicarboxylic acid4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-Ethinyl estradiolHis-His-Arg7-Amino-4-methylquinolin-2-olN-Arachidonoyl-.gamma.-aminobutyric acidDiazepam7.alpha.-Hydroxy-4-cholesten-3-one2'-O-Acetyl-3'-O-(4-hydroxy-2-methoxy-6-methylbenzoyl)uridine13-Hydroxy-6-(1-hydroxyethyl)-12,14-dimethyl-3-methylidene-15-nonyl-9-(propan-2-yl)-1-oxa-4,7,10-triazacyclopentadecane-2,5,8,11-tetroneDimethyl 2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylateLipoxin A4Lys-ValParaoxonPyrrocidine BTropinoneHydromorphoneall-trans-4-Ketoretinoic acid5-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazoleLeu-AsnVincamonePheophorbide aPentobarbitalNeomycinAmlodipineMyclobutanilCholine cationLys-Tyr-ArgDehydropipernonaline4-(4-Chlorophenyl)-2-phenyl-1,3-thiazole[2-(6,7-Dimethoxyquinazolin-4-yl)-5-(2-pyridyl)-1,2,4-triazol-3-yl]amine8-iso-Prostaglandin A2-biotin[6,10a-Dihydroxy-4-(hydroxymethyl)-4,7,11b-trimethyl-9-oxo-1,2,3,4a,5,6,6a,7,11,11a-decahydronaphtho[2,1-f][1]benzofuran-5-yl] acetate6H-2-Benzopyran-6-one, 5-chloro-3-(3,4-dihydroxy-3,5-dimethyl-1-hepten-1-yl)-7,8-dihydro-7,8-dihydroxy-7-methyl-1-(3,4-Dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-oneMethoprotryneN.epsilon.-Methyl-L-lysineKanamycin APyrimidifenDihydrocelastryl diacetate1.alpha.-Methyl-5.alpha.-androstan-3.alpha.,17.beta.-diol glucuronideBenzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-N-[(3s,5s,7s)-Adamantan-1-yl]-1-(4-fluorobenzyl)-1H-indazole-3-carboxamideDinotefuranCannabinol4-NitrosodiphenylamineN-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamidePipradrol2,3-Dihydroxypropyl octadecanoate2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-hydroxyethoxy]phenyl]methyl]-PropafenoneAmetoctradin.alpha.-Pyrrolidinooctanophenone(Diethylamino)(oxo)acetic acidVal-PheAnastrozole1-Hexadecylpyridinium cationL-Phenylalanine, methyl ester4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenolBenalaxylPentazocineBenzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-1-O-Hexadecyl-2-O-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glyceryl-3-phosphorylcholine1,2-Bis(O-octanoyl)-sn-glycerylphophorylcholineKukolineTurkesteronePenbutolol2-(1-Adamantyl)-N-hydroxyacetamideCiprofloxacinCyanazine(2E)-1-(4-Methoxyphenyl)-3-(4-pyridinyl)-2-propen-1-oneN-2-Hydroxyethylpiperazine-N-3-propanesulfonic acid3-HydroxyhexadecanoylcarnitineLys-Ile-Arg.beta.-Muricholic acidN-Methyltryptophan1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-(ethoxymethyl)-.alpha.,.alpha.-dimethyl-Praziquantel(7E)-11,12,13-Trihydroxy-4,5,8-trimethyl-3-(2-methylpropyl)-3,3a,4,6a,9,10,11,12,13,14-decahydro-1H-cycloundeca[d]isoindole-1,15(2H)-dioneGuanosineGriseophenone BNeoandrographolideTrimethoprimCytochalasin E7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecinRabeprazole4-(4-Methylpiperazino)benzoic acidCytochalasin AChlorpromazine5'-S-Methyl-5'-thioadenosineDehydrosalsolidineNeomangiferin3-deoxo-3beta-acetoxydeoxydihydrogeduninN-3-Oxotetradec-7Z-enoyl-L-homoserine lactoneVal-Glu-Lys2,4-Diethyl 5-acetamido-3-methylthiophene-2,4-dicarboxylate5-[Bis(2-chloroethyl)amino]uracil3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-VerruculotoxinN-(2-Amino-4-ethoxyphenyl)acetamide5-Methoxycarbonylamino-N-acetyltryptaminePro-Lys-ArgLys-IleN,N-DimethylsphingosineHydroxybutorphanol.alpha.-Pyrrolidinononanophenonetrans-Zeatin4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)butanoic acid2-{[4-(Dipentylamino)-2-hydroxyphenyl]carbonyl}benzoic acidtrans-Epoxysuccinyl-L-leucylamido(4-guanidino)butaneHC ToxinN-(4-Ethoxyphenyl)-N'-(4-fluorophenyl)urea3.alpha.-Hydroxy-7-oxo-5.beta.-cholanic acidImazamoxD-MannosaminePindolol1-(4-Bromobenzyl)-4-(2-pyridinylmethyl)piperazine2-Amino-4-methoxybutanoic acidHuperzine BAcetyl-DL-carnitine2,4-Diamino-6-nitrotoluene5-(Trifluoromethyl)pyridine-2-carboxylic acid3-Hydroxy-N-(4-methylphenyl)-2-naphthamide4-Androsten-17.beta.-ol-3-one sulfateSer-Ile-LysPuromycinCyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl]2,5-Dimethyl-4-pyrimidinamineN-Cyclohexyl-N'-(tetrahydro-2-furanylmethyl)urea2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1H-Indole-3-carboxylic acid, 1-(cyclohexylmethyl)-Man3 aL-Arginine, methyl esterPhe-Met-ArgPyroquilonTestosterone cypionateThr-Ala5-(2-Phenylethyl)-1H-pyrazole-3-carboxylic acidEmetineAspartic acid3-Benzoylalanine.alpha.-Methyl-L-tyrosineGly-Val-LysSwainsonine(7E)-11,12-Dihydroxy-13-methoxy-4,5,8-trimethyl-3-(2-methylpropyl)-3,3a,4,6a,9,10,11,12,13,14-decahydro-1H-cycloundeca[d]isoindole-1,15(2H)-dione1,2-Dilauroyl-sn-glycero-3-phosphate(4-Benzylpiperidin-1-yl)(4-methylphenyl)methanone1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine(-)-EpinephrineSuberylglycine4-(tert-Butylamino)-6-ethylamino-5H-1,3,5-triazin-2-one[(2R,3R,4S,5S,6R)-2-(Acetyloxymethyl)-5-hexanoyloxy-3-hydroxy-6-[(2S,3R)-2,3,4-trihydroxybutoxy]oxan-4-yl] tetradecanoate1-(1-Phenylethyl)hydrazineHexanamide, N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-N-[4-(4-Ethylpiperazin-1-yl)phenyl]benzo[g]quinolin-4-amineSulfamonomethoxine5.alpha.-Androstan-17.beta.-ol-3-oneN-Benzyl-2-(2-fluorophenoxy)ethanamineArgininosuccinic acidMalaoxon3-Methyl-L-histidine.beta.-HomoprolineMultiflorosideMet-Met-ArgGinsenoside RfN,N-Dimethyl-N-(2-phenoxyethyl)-1-dodecanaminium cationLevofloxacinEtrimfosSucrose9-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione(4r)-4-((5s,7r,9s,10s,13r,14s,17r)-7-hydroxy-10,13-dimethyl-3-oxohexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acidtert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate2'-Deoxyguanosine 5'-monophosphaterac-N'-Nitrosonornicotine 1-N-oxideTrachelanthine17-OxodexamethasoneEchinulinSerpentine cationSafranin1-DeoxynojirimycinMetoclopramide6-methoxybenzoxazolin-2(3h)-oneZanamivir2-(1-Phenylcyclopentyl)acetic acid4-Hydroxy-L-isoleucineDye X-732-100EaOphthalmateCarbobenzyloxyglycyl-L-norleucine methyl ester1-(Tetrahydro-2H-thiopyran-4-yl)piperazine1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-4-hydroxy-.alpha.-(1-methylethyl)-2-oxo-, (.alpha.S)-Trichostatin AN-Acetyl-.beta.-D-mannosamine.gamma.-Glu-.epsilon.-Lys1-(1-Benzylpiperidin-4-yl)-4-(methylsulfonyl)piperazineLeu-AlaTaurocholic acidFingolimodVal-ProLopinavirMecillinamFenoxycarbSpectinomycinDienestrolMethyl 1-piperazinecarboxylateAlbendazole sulfoneLys-Lys-LysDihydro-.beta.-erythroidinePolygodialHydroxygardnutinePerindopril1-Behenoyl-2-hydroxy-sn-glycero-3-phosphocholine2-heptyl-3-hydroxy 4-quinoloneTrihydroxycoprostaneIvacaftorDemecolcineN-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide2-(1-Piperidinyl)ethyl 1-phenylcyclopentanecarboxylateVal-TyrAla-Leu-ArgArg-GluN5-(1-Imino-3-butenyl)-L-ornithineZearalenoneRotundineTetraethylene glycol1,2-Benzenediamine, 4-methyl-N1-(3-phenylpropyl)-Leu-Glu-ArgCumaroylspermidine2-(4-Amino-1-piperidinyl)ethanolCrufomate{[(4-Hydroxyphenyl)acetyl]amino}acetic acid3'-Fluoro-.alpha.-pyrrolidinopropiophenone1,2-Diarachidonoyl-sn-glycero-3-phosphocholine4-CholestenoneRitalinic acidAlprenololMepacrineNonanohydrazideOleandrinIpecosideProsulfocarbCreatinineHis-GluDexpanthenolDexamethasoneOleana-1,9(11)-dien-28-amide, 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-(4S,4aR)-4-(Hydroxymethyl)-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-oneN2-Isobutyryl-2'-deoxyguanosinePyridoxineOrphenadrineL-Arginine ethyl ester2-(2-Amino-4-nitroanilino)ethanolFallacinolGaliellalactonetrans-Ferulic acid4-Amino-2-methyl-5-pyrimidinemethanolOxethazaine(+)-ChlorpheniramineStachydrineNicotinamide riboside cationCarisoprodolCyclostachnine BArachidonoyl ethanolamide1-(1Z-Hexadecenyl)-sn-glycero-3-phosphocholine1-(4-Ethoxyphenyl)urea1-(2-Hydroxyethyl)pyrazoleAcepromazine4-Quinazolinamine, N-[1-(cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-Linoleoyl ethanolamidePhe-Thr-ArgGomisin J4-Imidazoleacetic acidO-t-Butyl-L-serine, methyl esterGomisin DIsoxathionUrobilin16.alpha.-HydroxyestroneBetaine2.alpha.-Mannobiose17-Phenyltrinorprostaglandin E2 serinolamidePhenacetin1-Benzyl 2-(1-ethylhexyl) phthalateJasmonic acidAla-Glu-ArgCholestan-3-one, (5.alpha.)-Asn-LysTerconazoleGamma-tocotrienolPiperettineN-Benzyl-4-tert-butylbenzamideL-beta-homothreonineAtenololCytidinePipernonaline3-(6-Amino-9H-purin-9-yl)propan-1-olLys-Phe-Arg(1,4a-Dimethyl-6-methylidene-5-(2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl)methyl 6-O-(carboxyacetyl)hexopyranosideN1-(4-Nitrophenyl)-1,3-propanediamineN-(4,6-Dimethyl-2-pyridinyl)-4-ethoxybenzamideThalsimine(3Z)-6-Hydroxy-3-(1H-imidazol-5-ylmethylidene)-12-methoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dioneMethyl arachidonyl fluorophosphonateEthylmorphineVal-Gln-ArgImazamethabenz-methyl3-Hydroxy-4,4,6a,9,12b-pentamethyl-3,4,4a,6,6a,12,12a,12b-octahydro-2H,9H-benzo[f]pyrano[2,3-b]chromene-1,11(5H,10H)-dioneAlfentanylGly-Lys1-(3,4-Dihydroxy-5-methoxyphenyl)-7-(3,4-dihydroxyphenyl)heptan-3-oneHydrocortisone7-[(2,6-Dihydroxy-2,5,5,8a-tetramethyldecalin-1-yl)methoxy]coumarin4-(2-Cyclohexylethoxy)anilinePiperonyl sulfoxideProtubonine AN-Heptanoyl-L-homoserine lactone2-(4-Amino-1-piperidinyl)-N-methylacetamideTris(2-butoxyethyl) phosphate7-Methyl-4,5-dihydroindeno[1,7-bc]acridineMethanone, [5-(3-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-8-Quinolinyl 1-piperidinecarboxylate4-Amino-2-methylbenzamide2-HydroxyestronePhosmetN4-acetylsulfadimethoxineGlutathione, oxidizedRactopamineSer-Asn-Lys1-PalmitoylglycerolMyristoyl-L-carnitineCodeineMethanone, (1-naphthalenyl)(9-pentyl-9H-carbazol-3-yl)-Progesterone6.beta.-Hydroxytriamcinolone acetonide5'-(Furan-3-yl)-4a-hydroxy-4,7-dimethylspiro[5,6,7,8a-tetrahydro-1H-naphthalene-8,3'-oxolane]-2,2'-dioneXanthohumolN1-(2-Nitrophenyl)-1,3-propanediamine8,9-Dihydroxy-5Z,11Z,14Z-eicosatrienoic acid7-Hydroxycoumarinyl .gamma.-linolenate2-Amino-4-methylpentanoic acid ethylamide.gamma.-linolenic acid.delta.-Tocotrienol4-Aminopyridine2-{4-[3-(Trifluoromethyl)phenyl]piperazino}-1-ethanamine4-Guanidinobutyric acidMorronisideAtropine1-Benzyl-2-ethyl-1,5,6,7-tetrahydro-4H-indol-4-oneMavorixaforRhynchophylline17-Trifluoromethylphenyltrinorprostaglandin F2.alpha. methyl ester3-Indoleacrylic acidLisinoprilThiamine monophosphateN-(4-Aminobenzoyl)-.beta.-alaninePodofiloxAlloxydimMethyl (19.alpha.,20.alpha.)-11-methoxy-19-methyl-16,17-didehydrooxayohimban-16-carboxylate2-methoxy-4-pentadecylbenzoic acid2'-DeoxyinosineCastanospermine1H-Indazole-3-carboxamide, 1-(5-hydroxypentyl)-N-tricyclo[3.3.1.1(3,7)]dec-1-yl-Muramic acid3-(Dimethylamino)propyl imidothiocarbamate1-Palmitoyl-2-azelaoylphosphatidylcholine(3'S,4S,6R,7R)-7-Hydroxy-3',6,7,14-tetramethyl-8H,17H-spiro[2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-4,2'-oxirane]-3,8,17-trionePentostatinNalbuphineFlindersine4'-O-.beta.-D-Glucosyl-5-O-methylvisamminolN-ArachidonoyltaurinePeruvininetrans-4-(Aminomethyl)cyclohexanecarboxylic acidTafluprost ethylamide2'-DeoxycytidineLys-Gln-ArgN-.alpha.-Acetyl-L-ornithineLinezolid2,6-Di-tert-butyl-4-(4-morpholinylmethyl)phenolN-(4-Bromo-3-methylphenyl)-3-(morpholin-4-yl)propanamideVal-HisL-.beta.-Homoglutamine2,4-Di-tert-butyl-6-[(dimethylamino)methyl]phenolAustalide D(9Z,12Z)-15-Hydroxy-16-methoxyoctadeca-9,12-dienoic acid2-(4,4-Difluorocyclohexyl)ethan-1-amineThr-Val(-)-RiboflavinClerodinLincomycinSpironolactone4-Methoxy-N-(4-nitrophenyl)benzamideIle-ProButanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-Lys-Phe3-[(Cholamidopropyl)dimethylammonio]-1-propanesulfonateMetolazone2-(5-acetyl-2,3-dihydro-1-benzofuran-2-yl)prop-2-enyl 3-methylbutanoate1H-Indazole-3-carboxamide, N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-[(4-fluorophenyl)methyl]-(3R,6S,6aS,10S,12aS,13aR,14S)-1-Ethyl-12a,14-dihydroxy-6-methoxy-3-methyl-8-oxotetradecahydro-7H-3,6a,13-(epiethane[1,1,2]triyl)-7,10-methanooxepino[3',4':4,5]benzo[1,2-b]azocine6-Ketotestosterone enanthateDye X-26647-194PyridateNiacinamideSalsolinolSerotonin4-(3,5-Dimethyl-4H-1,2,4-triazol-4-yl)piperidine(2R)-3-(tert-Butylamino)propane-1,2-diolN-3-Oxohexadec-11Z-enoyl-L-homoserine lactoneN-Tris(hydroxymethyl)methyl-4-aminobutanesulfonic acidNordihydroguaiaretic acidL-HomoarginineN-Methyl-L-isoleucineClidinium cation1,4-D-XylobioseIsovaleryl-L-carnitine3-Quinolinecarboxamide, 1,4-dihydro-8-methoxy-4-oxo-1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-OstholeEstra-1,3,5(10),7-tetraene-3,17.beta.-diolN-(3-Methoxyphenyl)ureaN-(3-Methylbutanoyl)valine2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide13-oxoodeCrotamitonL-Homocitrulline1-O-Hexadecyl-2-O-(2E-butenoyl)-sn-glyceryl-3-phosphocholine1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-all-trans-Retinoic acid methyl esterBenfuresateHexylamineAprepitant .beta.-glucuronide (position of glucuronide on triazolone ring uncertain)4-[3-(Trifluoromethyl)benzyl]piperidine5-Androstene-3.beta.,17.beta.-diolL-leucyl-l-prolineN-(.alpha.-Linolenoyl)tyrosineBudesonideMetaflumizone3'-Methyl[1,1'-biphenyl]-3-carboxylic acidButuron1-(4-Aminobutyl)ureaMyristamine oxideSulfamic acid, N,N-dimethyl-, 4-nitrophenyl ester1,24-Dihydroxyvitamin D3Harmine3-{3-oxo-2H,3H-[1,2,4]Triazolo[4,3-a]pyridin-2-yl}propanoic acidAcetyleugenolAnabasaminePhytosphingosinePro-hypFenpropimorph3,6-Diphenylcyclohexane-1,2-diol3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octaneTyr-Tyr-LysEvoxineRhodamine B cationLewis X trisaccharidePropranololHarpagoside[4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl]piperazinomethanoneTyrosineLeu-Gln-Arg(2E)-3-Cyclohexyl-2-butenoic acidLevamisole2-Pyrrolidinone, 5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-, (5R)-Enniatin a15-Isopropyl-3-isoxazolecarboxylic acid2-(2',3',4'-Trihydroxybutyl)quinoxalineHellebrigenin-3-O-.beta.-glucosideQuinine2S-Amino-4E-pentadecene-1,3R-diolLys-Ala2-{[5,6-Bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}ethanolHydroxychloroquineN-(2'-Cyanobiphenyl-4-ylmethyl)-L-valine methyl ester1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)ethanoneMethyl (2E,8E)-9-[3a-hydroxy-6,7-dimethyl-1-(2-methylpropyl)-3-oxo-2,4,7,7a-tetrahydro-1H-isoindol-4-yl]-4,5-dihydroxy-8-methylnona-2,8-dienoate5-(4-Methylpiperazin-1-yl)-5-oxopentanoic acid5-Chloro-2-(4-propionyl-1-piperazinyl)anilineHypoxanthinePhe-ArgIle-Phe-ArgPalmitoyl ethanolamideLinamarin1,7-Bis(4-hydroxyphenyl)heptan-3-yl 6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranoside15.beta.-Hydroxycyproterone acetateBetaxolol1-Decanoyl-2-hydroxy-sn-glycero-3-phosphocholineLeu-Phe3-(.beta.-D-Galactopyranosyloxy)-2-hydroxypropyl (9Z,12Z)-octadeca-9,12-dienoateAndrostan-3-ol-17-one 3-glucuronide4,6,8-Trimethylquinolin-2-olLevallorphanCyclopropanecarboxamide, N-[(1S)-2-[4-(5-bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-phenyl-, (1R,2R)-SaluaminePhenylethylamineGln-Leu-LysN8-AcetylspermidineN5-(1-Iminobutyl)-L-ornithineAscorbic acid 6-palmitatePro-Met3-HydroxyoleylcarnitineMetolachlor morpholinone1-(3-Bromophenyl)-3,5-dimethylpyrazolePentamethylene bisacetamide(2.beta.,3.alpha.,5.alpha.,16.beta.,17.beta.)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstaneN-(9-(Butan-2-yl)-21-(4-methoxybenzyl)-18,22-dimethyl-5,8,11,16,20,23-hexaoxo-6-(propan-2-yl)icosahydro-5H,16H-dipyrrolo[2,1-f:2',1'-o][1,4,7,10,13,16]oxapentaazacyclononadecin-17-yl)acetamide(.+,-.)-Quinuclidinyl benzilateTrp-Gly-Lys8-(3-Octyl-2-oxiranyl)octanoic acid2-(3-Hexyl-4-methyl-2,5-dioxopyrrol-1-yl)-3-hydroxypropanoic acidPhe-TyrIle-Val-LysDocosan-1-amine(2R)-N-(3-Ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide(2,6-Dihydroxy-4-methoxyphenyl)(4-hydroxy-2-methoxy-6-methylphenyl)methanoneQuinoline-2,8-diolN,N'-Diacetylcystine3-(3,4,5-Trimethoxyphenyl)propanohydrazideAdenine1H-1,2,3-Triazole-1-octanamide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-Gln-Lys3-[N,N-Bis(2-hydroxyethyl)amino]-2-hydroxypropanesulfonic acid2-(4-Fluorophenyl)-N-(2-methoxybenzyl)ethanamine1-Stearoyl-sn-glycerol 3-phosphocholine(LPC(18:0))Hydroxycerivastatin2-(4-tert-Butylbenzoyl)benzoic acid2-(2,3-Dimethylphenyl)-7-methyl-1,2,4-triazaspiro[4.5]decane-3-thione2-(4-tert-Butylphenoxy)ethanamine2-Hydroxyatorvastatin lactoneHydroquinidineEnalaprilatCys-Leu-LysPurine(5E)-4,7,8-Trihydroxy-2-(2-hydroxypentyl)-9,9-dimethyl-3,4,7,8-tetrahydro-2H-oxecin-10-oneIle-Arg13,14-Dihydro-15-ketoprostaglandin D1DL-tyrosine1-Methyl-L-histidinePropargiteMethyl 3-[3,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-2-[[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]methyl]-4-methoxy-5-oxofuran-2-carboxylate2-Naphthalenecarboxamide, N-[(1S)-2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-PrimaquineMedroxyprogesterone 17-acetateSoyasaponin iD-Desthiobiotin2'-Deoxyadenosine 5'-monophosphateCarnosolL-Propionylcarnitine2-methoxy-3,5-dimethyl-6-[(4z)-4-[(e)-2-methyl-3-(4-nitrophenyl)prop-2-enylidene]oxolan-2-yl]pyran-4-oneLNTLys-GlyBenzoylecgonine1,5-PentanediaminePirimicarb2-(1H-Indol-3-yl)-2-(4-methoxyphenyl)ethanamineN-Methyl-L-histidine4-[2-(6,7-dihydroxy-1,2,4a-trimethylspiro[3,4,6,7,8,8a-hexahydro-2h-naphthalene-5,2'-oxirane]-1-yl)ethyl]-2-hydroxy-2h-furan-5-one(4R,10E)-3,11-Dimethyl-4,8,9,12-tetrahydro-4,7-(metheno)furo[3,2-c]oxacycloundecin-6-oneCaffeine10-Nitrooleic acidScrophularoside A8.alpha.-Tocotrienol4-(1H-Inden-1-ylidenemethyl)phenylamine2-(Dipentylamino)-2-(hydroxymethyl)-1,3-propanediol2-Amino-N-cyclopentyl-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamideMethyl 1-(2-Methoxyethyl)-2-oxopyrrolidine-4-carboxylateMaltotrioseEthyl 4-methyl-5-[(propan-2-yl)oxy]-9H-pyrido[3,4-b]indole-3-carboxylate15-Deoxy-.DELTA.12,14-prostaglandin J2 glutathione.beta.-AlanylleucineL-MethionineN-Methyltyramine3-Methyl-1-(4-nitrophenyl)-1H-pyrazol-5-olMethyldopaN-AcetylhistaminePentedrone2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylN-(3-Methoxypropyl)-2-(phenylsulfanyl)acetamide(3.beta.,4.alpha.,16.alpha.)-17-Carboxy-16-hydroxy-23-oxo-28-norolean-12-en-3-yl O-.beta.-D-galactopyranosyl-(1->2)-O-[.beta.-D-xylopyranosyl-(1->3)]-.beta.-D-glucopyranosiduronic acidMethyl (9Z,14Z)-12,13,16-trihydroxyoctadeca-9,14-dienoateNeofusapyrone1-MonolinoleninN.alpha.-Acetyl-L-lysine(1R,4aR,4bS,6aS,9R,10R,10aS)-1-(Carboxymethyl)-10-hydroxy-2-(1-methoxy-2-methyl-1-oxopropan-2-yl)-1,4a,4b,9,10-pentamethyl-3,4,5,6,7,8,9,10a,12,12a-decahydro-2H-chrysene-6a-carboxylic acid5-(2-Hydroxyethyl)-4-methylthiazoleDigoxigenin bisdigitoxosideSuccinic acid N,N-dimethylhydrazideVal-Leu-ArgIle-TrpZectranCyprodimeDinitramine4-Amino-1,2-benzenediolAncymidolDiferuloyl putrescineCys-Pro-ArgGln-Ala-LysN-Methyl-L-threonine2-[(Dibenzylamino)carbonyl]benzoic acidPyridoxamine4,4'-(Propane-2,2-diyl)bis(2-aminophenol)DesferrichromeBenzoic acid, 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]-ErgosterolAsclepin3-Methoxy-4-(1,3-oxazol-5-yl)anilineAmorfrutin A2-Chloro-N-[2-(4-morpholinyl)ethyl]nicotinamideGinsenoside F1S-AdenosylmethionineHis-Asn-ArgProtriptylineIsopropalinNylidrinMefenamic acid1-(5,10-Dioxo-2,3,5a,6,7,8-hexahydro-1H-dipyrrolo[1,2-d:1',2'-f]pyrazin-10a-yl)propan-2-yl carbamateAla-Leu-LysL-Norvaline2-LinoleoylglycerolEthyl [5-(methylcarbamoyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-3-yl]carbamateVal-Lys1-Pentadecanoyl-sn-glycero-3-phosphocholineMethanone, [1-(hexahydro-1-methyl-1H-azepin-3-yl)-1H-indol-3-yl]tricyclo[3.3.1.1(3,7)]dec-1-yl-CamptothecinManoalideThr-Cys-ArgLeu-Glu1-(2,5-Dimethylphenoxy)-3-(4-morpholinyl)-2-propanolMontelukast acyl-.beta.-D-glucuronideLabetalolDesisopropyldisopyramideIsogibberellin A33-((Ethoxy(hydroxy)phosphoryl)oxy)-2-hydroxypropyl (9Z,12Z)-octadeca-9,12-dienoateCostunolideN2,N4-Bis(2-methoxyethyl)-2,4-pyridinedicarboxamideN-[2-(1H-Imidazol-4-yl)ethyl]-N'-(2-phenylethyl)thioureaTramadol(2e,4e)-n-(2-methylpropyl)-6-thiophen-2-ylhexa-2,4-dienamideCamylofinePlatyphyllonolDiethyl L-glutamate(4r)-4-((3s,5s,7s,9s,10s,13r,14s,17r)-3,7-dihydroxy-10,13-dimethyl-12-oxohexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acidProscillaridin A3-(4-Formylaminobutyryl)pyridineN-[1,3-Dimethyl-2-oxo-6-(1-pyrrolidinyl)-2,3-dihydro-1H-benzimidazol-5-yl]-2-methoxybenzamideTramadol n-oxideOleoylserotonin4-Piperidinepropanoic acid, .beta.-oxo-1-[(phenylmethoxy)carbonyl]-, ethyl esterN-Arachidonoyl-L-serineDeoxycorticosterone acetate(4R)-4-Methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-oneErucamide3-rha(1-2)gal(1-2)glua-soyasaponenol b2-Naphthalenol, 1-[2-(2,4-dimethylphenyl)diazenyl]-Imiprothrin(2E)-3-(1H-Indol-2-yl)-2-propenoic acidTetracycline3a,8-Dihydroxy-3,5a,9-trimethyl-4,5,6,7,8,9b-hexahydro-3H-naphtho[6,5-d]furan-2-one21-Amino-3,20-dihydroxydocosan-2-yl hexopyranosideHistamineGln-MetMiltefosineEplerenoneMethyltyrosinatePyroGlu-Gly-Arg2(1H)-PyridinoneInulicinAtglistatinLeu-Leu-Lys14,17,20-Trihydroxy-1-oxowitha-2,5,24-trienolide7-EthoxyresorufinHeptadecasphing-4-enineAcetylcitrullineBenzyloxycarbonylglycinePhe-PheMitragynineN,n,n-trimethyllysineOxycodoneN-(2-Ethyl-6-methylphenyl)hydrazinecarbothioamideL-Leucyl-L-leucine methyl esterSenecionineOleoyl 3-carbacyclic phosphatidic acid(1E)-6-Hydroxy-12-(1H-indol-3-ylmethyl)-7-methoxy-4,13,13a-trimethyl-5,6,7,8,12,12a,13,13a,14a,14b-decahydro-3H-cycloundeca[d]oxireno[f]isoindole-9,10(4H,11H)-dioneL-Carnosine1-acetylimidazolePyrrolidineDihydroevocarpineChrysophanol1-Methoxy-N-(4-methylbenzyl)-2-propanamineSebuthylazine1-(Benzoyloxy)propan-2-yl benzoateNicotinate(6E)-2,10-Dihydroxy-2,6,10-trimethyldodeca-6,11-dien-3-yl .beta.-D-glucopyranosideImazethapyrAla-Glu-LysN-acetylhistidine6-((E)-2-((1R,2S,3R,5S)-3,5-Dihydroxy-2-((Z)-oct-2-enyl)cyclopentyl)vinyl)tetrahydro-2H-pyran-2-one3-Hydroxy-2-((9Z,12Z)-octadeca-9,12-dienoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphateProstaglandin A1-biotinIsatinGlycodeoxycholic acidPhe-AlaNorvaline, 5-phosphono-(3E)-4-Hydroxy-3-[hydroxy-[2-[(1E,3E)-6-hydroxyhepta-1,3-dienyl]-1,3,6-trimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]methylidene]-5-(hydroxymethyl)-1-methylpyrrol-2-one4-[(Isobutylamino)methyl]benzoic acid.beta.-D-Glucopyranosiduronic acid, 5-[3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indol-1-yl]pentylfalsePrevention of acute graft-versus-host disease via single-dose administration of bioengineered extracellular vesiclesAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for various hematological and immunologic diseases, but acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality. We previously discovered in patients and murine models that higher levels of pro-inflammatory signals before stem cell infusion are associated with the severity of aGVHD. Here, we show that extracellular vesicles (EVs) mediate the intracellular delivery of SOCS3 (suppressor of cytokine signaling 3), resulting in reduced inflammatory signaling and macrophage/dendritic cell (DC) activation. Furthermore, single-dose treatment with engineered SOCS3-loaded EVs (eEVs) significantly prevented aGVHD and increased survival in multiple murine models without compromising graft-versus-leukemia activity. Mechanistically, single-cell transcriptomics revealed that eEVs induced transcriptional features associated with an immunoregulatory milieu in recipients before allo-HSCT, and then suppressed excessive immune responses, resulting in aGVHD alleviation. In summary, delivery of SOCS3 via EVs represents a promising avenue for aGVHD prophylaxis, with great potential to improve allo-HSCT outcomes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