At the same time, the metabolites were identified by searching database, and the main databases were the HMDB (http://www.hmdb.ca/), Metlin ( https://metlin.scripps.edu/)
"],"repository":["MetaboLights"],"study_status":["Public"],"ptm_modification":[""],"instrument_platform":["Liquid Chromatography MS - negative - reverse-phase","Liquid Chromatography MS - positive - reverse-phase"],"chromatography_protocol":["The LC-MS/MS analysis of sample was conducted on a Thermo UHPLC-Q Exactive HF-X system equipped with an ACQUITY HSS T3 column (100 mm × 2.1 mm i.d., 1.8 μm; Waters, USA) at Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China). The mobile phases consisted of 0.1% formic acid in water:acetonitrile (95:5, v/v) (solvent A) and 0.1% formic acid in acetonitrile:isopropanol:water (47.5:47.5, v/v) (solvent B). The flow rate was 0.40 mL/min and the column temperature was 40℃. The injection volume was 3 μL.
"],"publication":["Beinaglutide modulates abdominal subcutaneous adipose tissue microenvironment and lipid metabolism in diet-induced obese mice: a multi-omics analysis."],"submitter_name":["Lihua Zhou"],"submitter_affiliation":["Hebei North University"],"organism_part":["adipose tissue"],"technology_type":["mass spectrometry assay"],"disease":[""],"extraction_protocol":["50 mg solid sample was added to a 2 mL centrifuge tube and a 6 mm diameter grinding bead was added. 400 μL of extraction solution (methanol: water = 4:1 (v:v)) containing 0.02 mg/mL of internal standard (L-2-chlorophenylalanine) was used for metabolite extraction. Samples were ground by the Wonbio-96c ( Shanghai wanbo biotechnology co., LTD) frozen tissue grinder for 6 min (-10°C, 50 Hz), followed by low-temperature ultrasonic extraction for 30 min (5°C, 40 kHz). The samples were left at -20°C for 30 min, centrifuged for 15 min (4°C, 13000 g), and the supernatant was transferred to the injection vial for LC-MS/MS analysis.
"],"organism":["Mus musculus"],"full_dataset_link":["https://www.ebi.ac.uk/metabolights/MTBLS15659"],"author":["Lihua Zhou. Hebei North University. 18770364141@163.com."],"data_transformation_protocol":["The pretreatment of LC/MS raw data was performed by Progenesis QI (Waters Corporation, Milford, USA) software, and a three-dimensional data matrix in CSV format was exported. The information in this three-dimensional matrix included: sample information, metabolite name and mass spectral response intensity. Internal standard peaks, as well as any known false positive peaks (including noise, column bleed, and derivatized reagent peaks), were removed from the data matrix, deredundant and peak pooled.
"],"study_factor":["Treatment"],"submitter_email":["18770364141@163.com"],"sample_collection_protocol":["In this study, C57BL/6J mice underwent a high-fat diet (HFD) for 12 weeks to induce obesity, followed by a 7-week treatment with BN. Evaluations of metabolic phenotypes, serum biochemical parameters, adipose tissue morphology, and multi-omics profiles of abdominal subcutaneous adipose tissue were conducted through transcriptomic, proteomic, and untargeted metabolomic analyses.
"],"omics_type":["Metabolomics"],"study_design":["Thermo Scientific Vanquish UHPLC System","Metabolomics","Obesity","Mus musculus","untargeted analysis","inflammation","Thermo Scientific Q Exactive HF-X","adipose tissue","Beinaglutide","Lipid Metabolism","GLP-1 receptor agonist"],"curator_keywords":["Thermo Scientific Vanquish UHPLC System","Metabolomics","Obesity","Mus musculus","untargeted analysis","inflammation","Thermo Scientific Q Exactive HF-X","adipose tissue","Beinaglutide","Lipid Metabolism","GLP-1 receptor agonist"],"mass_spectrometry_protocol":["The mass spectrometric data were collected using a Thermo UHPLC-Q Exactive HF-X Mass Spectrometer equipped with an electrospray ionization (ESI) source operating in positive mode and negative mode. The optimal conditions were set as followed: source temperature at 425℃; sheath gas flow rate at 50 arb; Aux gas flow rate at 13 arb; ion-spray voltage floating (ISVF) at -3500V in negative mode and 3500V in positive mode, respectively; Normalized collision energy , 20-40-60V rolling for MS/MS. Full MS resolution was 60000, and MS/MS resolution was 7500. Data acquisition was performed with the Data Dependent Acquisition (DDA) mode. The detection was carried out over a mass range of 50-1050 m/z.
"],"metabolite_name":["LysoPC(20:3(8Z,11Z,14Z)/0:0)","Isoleucyl-Tyrosine","DL-2-Aminooctanoic acid","Vinylacetylglycine","Riboflavin","DG(22:4(7Z,10Z,13Z,16Z)/22:5(4Z,7Z,10Z,13Z,16Z)/0:0)","Tryptophan 2-C-mannoside","5-Octadecynoic acid","TRIPHENYLPHOSPHINE","Acetaldehyde oxime","PC(P-18:1(9Z)/18:0)","Butyryl trihexyl citrate","(S1)-Methoxy-3-heptanethiol","Aspartame","Guaiacol","Stearoylcarnitine","N-(3-Methylbutyl)acetamide","Pantothenol","Quinoline","Altretamine","Pemirolast","L-Histidine","Telocinobufagin","LysoPC(0:0/18:2(9Z,12Z))","Phenanthrene","Polidocanol","(2R)-2-[[(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid","Coumatetralyl","TRIPHENYL PHOSPHATE","Methylphosphate","Citrulline","PE(18:1(9Z)/18:1(9Z))","L-Proline","Phenol","Antipyrene","Labienoxime","1-Oleoylglycerophosphoserine","Inuline","4-Hydroxybenzaldehyde","DG(14:1(9Z)/18:0/0:0)","LysoPC(O-18:0/0:0)","5-Hydroxyindoleacetic acid","Norecasantalic acid","indol-2-one","Dicyclohexylamine","Cyclohexylamine","Cinnamic acid","Phenylalanyltyrosine","alpha-Tocopherol","Toluene diisocyanate","Duryl aldehyde","Glycine","Ureidopropionic acid","Alanylleucine","Mevalonic acid","Phenylalanylglutamine","Stearoylethanolamide","PC(O-16:0/20:5(5Z,8Z,11Z,14Z,17Z))","3-Hydroxy-11Z-octadecenoylcarnitine","3b,18b-3-Methoxy-11-oxo-12-oleanen-30-oic acid","2,4,12-Octadecatrienoic acid isobutylamide","[7]-Paradol","Leucylleucine","PC(P-16:0/18:2(9Z,12Z))","1-Pyrrolidineethanol","Methyl (¡À)-2-methylpentanoate","D-ononitol","Hexadecylamine","2-Methylglutaric acid","Ginkgolide B","LysoPC(18:0/0:0)","PC(14:1(9Z)/15:0)","gamma-Glutamylphenylalanine","3-Hydroxyisovalerylcarnitine","2-Decenoylcarnitine","Proline betaine","Gossypetin 8-glucuronide 3-glucoside","LysoPE(16:1(9Z)/0:0)","Glutaminylisoleucine","Aspartyl-Tyrosine","Oleamide","Tiglylcarnitine","Methylergonovine","Lidocaine","Pantothenic acid","Tyrosyl-Serine","Allolithocholic acid","Methyl (2E,6Z)-dodecadienoate","Guanosine","2,6-Dimethoxy-4-(1-propenyl)phenol","Glyceraldehyde 3-phosphate","7-Ketocholesterol","Xanthurenic acid","TRIBUTYL PHOSPHATE","Diphenyl phosphate","Bicifadine","Indoleacetaldehyde","Octanoylcarnitine","Succinyladenosine","Phenylalanylalanine","13-Docosenamide","Asparaginylisoleucine","Tetradecanoylcarnitine","3alpha-Tigloyloxytropane N-oxide","Octaethylene glycol","Indole-3-acetylglycine","Brucine","Palmitoleoylethanolamde","Imatinib","Glycylvaline","(2E)-Piperamide-C5:1","Alanylphenylalanine","1,1,1-Trichloroheptane","(3E,5E,8Z)-Deca-3,5,8-trienedioylcarnitine","Clozapine N-oxide","PC(14:1(9Z)/P-16:0)","Alanyltyrosine","DG(2:0/6 keto-PGF1alpha/0:0)","O-Demethylmetoprolol","2-Methylindole","LysoPC(22:0/0:0)","Serylmethionine","Uridine","N-Butyrylglycine","Asparaginyl-Valine","Dutasteride","Ibuproxam","1-Methoxy-4-(2-propenyl)benzene","(S)-2-Propylpiperidine","SM(d18:0/16:1(9Z)(OH))","(10Z)-Pentadec-10-enoylcarnitine","Ornithine","Pindolol","PC(15:0/20:3(5Z,8Z,11Z))","3-hydroxydecanoyl carnitine","2-Hydroxymyristoylcarnitine","Isovalerylcarnitine","Indole","Geranylcitronellol","PS(15:0/18:0)","Benzamide","Cysteinyl-Cysteine","3-Hydroxymethylglutaric acid","Dibutylamine","4-hydroxyhexanoylglycine","6-Acetyl-2,2-dimethyl-2H-1-benzopyran","N-[1-[[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methyl-2-(propanoylamino)pentanamide","Prolyl-Valine","4-Hydroxybutyric acid","L-Carnitine","2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one","Leucyl-Glutamate","Dihydrodioscorine","13-OxoODE","Valylphenylalanine","Adenosine","Adenosine monophosphate","PC(16:0/18:1(9Z))","3-hydroxyhexadecanoyl carnitine","3-Oxo-5beta-cholanoic acid","N-Isobutyloctadeca-trans-2-trans-4-dienamide","2,4-Hexadien-1-ol","PC(15:0/P-18:1(11Z))","Phytal","PA(18:2(9Z,12Z)/24:1(15Z))","Asparaginyl-Tyrosine","Patulin","Epomusenin B","Pro-Ile","LysoPC(0:0/20:4(5Z,8Z,11Z,14Z))","Linoleic acid","N-NITROSO-N-METHYLURETHANE","Isoleucyl-Leucine","DG(14:0/18:2(9Z,12Z)/0:0)","L-Tyrosine","PC(16:0/18:2(9Z,12Z))","Diisopropyl sulfide","(2E,6Z)-2,6-Nonadien-1-Yl acetate","1-Naphthylamine","Isobutyryl-L-carnitine","Homo-L-arginine","Valyltyrosine","2,2'-Bioxirane","5,7,3',4'-Tetrahydroxyflavanone 7-alpha-L-arabinofuranosyl-(1->6)-glucoside","Benzoic acid","Betonicine","LysoPC(18:4(6Z,9Z,12Z,15Z)/0:0)","Thioproline","Felbamate","L-Phenylalanine","Phenylalanylphenylalanine","Stearidonic acid","Valylvaline","Trihexyphenidyl","gamma-Glutamyltyrosine","Alanyltryptophan","Phenformin","Atractylenolide II","PC(14:0/20:2(11Z,14Z))","Spermidine","Sphingosine","5-(10,13-Nonadecadienyl)-1,3-benzenediol","Phenylalanylvaline","Arginylphenylalanine","gamma-Glutamylleucine","Taurocholic acid","N-Formylphenylalanine","3-O-Methyl-a-methyldopa","1,3-Butadiene","7a-Hydroxy-5b-cholanic acid","3-Indolebutyric acid","Propionylcarnitine","Tyrosine methylester","4-Nitrophenyl phosphate","Aspartylphenylalanine","Furanofukinin","N-acetyl-L-2-aminoadipate(2-)","Bakers yeast extract","2-Butyl-1H-benzimidazole","Serylvaline","Phenylacetaldehyde","O-Linoleoylcarnitine","9-Hydroxytridecyl docosanoate","Stigmastane-3,6-dione","4-Formylaminoantipyrine","(3Z,6Z)-3,6-Nonadien-1-ol","(-)-Chimonanthine","LysoPC(16:1(9Z)/0:0)","Indole-3-carboxilic acid-O-sulphate","PC(18:1(11Z)/P-18:1(9Z))","Talbutal","Tetraethylene glycol","Phenylalanylthreonine","N-Lauroyl Leucine","Guanine","Octadecylamine","5'-Methylthioadenosine","Cer(d18:1/16:0)","LysoPE(22:4(7Z,10Z,13Z,16Z)/0:0)","PC(18:0/18:2(9Z,12Z))","m-Cresol","LysoPC(0:0/18:1(9Z))","Dimethyl sulfone","2-Hydroxypyridine","Creatinine","Isoleucyl-Asparagine","(2E,5Z,7E)-Decatrienoylcarnitine","PA(20:4(5Z,8Z,11Z,14Z)/24:1(15Z))","PS(15:0/18:2(9Z,12Z))","(2Z)-6-Hydroxynon-2-enoylcarnitine","Xanthosine","Dothiepin","Pimelic acid","1-O-Hexadecyl-sn-glycero-3-phosphocholine","3,4-Diaminopyridine","TG(14:0/14:0/18:3(6Z,9Z,12Z))","Glycylleucine","Diacetyl","Adenosine 2'-phosphate","MG(i-17:0/0:0/0:0)","DG(2:0/PGF1alpha/0:0)","3-Hydroxyhexanoylcarnitine","Pefloxacin","MG(0:0/a-17:0/0:0)[rac]","2-Phenylacetamide","Cimifugin","Sorbitan oleate","PA(13:0/18:1(12Z)-O(9S,10R))","Docosanamide","LysoPC(20:1(11Z)/0:0)","PC(14:0/P-18:1(11Z))","Hydroxycotinine","Cyclobarbital","Hexaethylene glycol","N-ethylmaleimide","Purpald","Palmitic amide","Glutamylvaline","3-Amino-1-methyl-5H-pyrido[4,3-b]indole","Arachidoyl Ethanolamide","5-[(1-Iminoethyl)amino]-2-aminopentanoic acid","Leucyl-Glutamine","SM(d18:0/24:1(15Z)(OH))","Pipecolic acid","4-(2-Aminoethyl)benzenesulfonyl fluoride","Copalic acid","Phenylalanyltryptophan","gamma-Glutamylvaline","Seryltryptophan","Dazomet","PA(16:1(9Z)/14:1(9Z))","Quifenadine","Betaine","Glycerol phenylbutyrate","4-Aminohippuric acid","Indole-3-carboxaldehyde","QUINUCLIDINE","Cer(d18:1/18:0)","Furanodienone","PA(15:0/PGJ2)","5alpha-Pregnane","Beta-Tyrosine","2,6-Dimethylbenzenethiol","Aacocf3","Aspartyl-Valine","1,3-Dihydro-(2H)-indol-2-one","MG(0:0/15:0/0:0)","N-[4-(Benzylamino)-3-cyanoquinolin-2-yl]-4-methoxybenzamide","LysoPC(17:0/0:0)","Dyphylline","Diethyl L-malate","LysoPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","Bethanidine","gamma-Glutamylalanine","Cucurbic acid","Tryptophol","Isoquinoline","(R)-1,2-dimethyl-5,6-dihydroxy-tetrahydroisoquinoline","L-Lysine","20-COOH-leukotriene E4","Capsiamide","LysoPE(18:0/0:0)","9,10-Epoxyoctadecenoic acid","1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine","2-Aminoadipic acid","Dimethylaniline-N-oxide","Cysteinyl-Proline","Trimethylamine N-oxide","Prostaglandin I2","1-(2-Furanyl)-1-octanone","Lysyl-Phenylalanine","N-Docosahexaenoyl Arginine","desmethylclomipramine","Isoleucyl-Threonine","Sulfanilic acid","6-Hexyltetrahydro-2H-pyran-2-one","Sphinganine","7alpha-Hydroxycholesterol","2,4,6-Trimethylpyridine","Tyrosyl-Leucine","Metoprolol","Chloroform","2-Naphthalenethiol","Thymine","2-Hydroxy-4-trifluoromethyl benzoic acid","Oleoylethanolamide","PC(18:0/18:0)","Tridodecylamine","3-Amino-4-hydroxybenzoic acid","Sarcosine","Maltol","L-beta-aspartyl-L-phenylalanine","Methionyl-Phenylalanine","Pivalic acid","DG(14:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","3,5,5-Trimethyl-2-cyclopenten-1-one","S-(2-Hydroxy-3-buten-1-yl)glutathione","1-Methylhistamine","PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","Valpromide","(3xi,5Z)-1,5-Octadien-3-ol","ID11614","7a-Hydroxy-cholestene-3-one","Dihydrocoriandrin","Arachidic acid","Paullinic acid","DG(18:1(9Z)/18:2(9Z,12Z)/0:0)","Methyl benzoate","Uridine 3'-monophosphate","O-Phosphoethanolamine","5-Dodecenoylcarnitine","Mannose 6-phosphate","Trospium","Cer(d17:1/LTE4)","L-Threonine","4-Hydroxy-2-butenoic acid gamma-lactone","hydroquinidine","Kynurenic acid","beta-Alanine","2-(Methylthio)ethanol","L-Leucine","Trigonelline","(4-Hydroxybenzoyl)choline","Phenylalanylleucine","SM(d18:1/18:1(9Z))","Palmitoylethanolamide","Glycerol","Stearaldehyde","Porphobilinogen","PA(15:0/PGF1alpha)","Ajmalicine","Leucyl-Valine","4,8-Dimethyl-3,7-nonadien-2-one, cis-","AICA-riboside","Chloral hydrate","PA(18:4(6Z,9Z,12Z,15Z)/24:1(15Z))","Styrene","Forskolin","Dichloromethane","3-Methyl-1-butylamine","SM(d18:1/14:1(9Z))","PS(14:0/18:2(9Z,12Z))","4-Hydroxyproline","L-Histidinol","Cryptotanshinone","PC(P-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))","N,N-Didemethyl orphenadrine","2,5-Dimethylpyrazine","Arachidonoylcarnitine","Carnosine","Leucyl-Glycine","Amydricaine","Diisopropylamine","Linoleamide","L-Norleucine","Icosa-8,11,14-trienoylcarnitine","Nicotine glucuronide","DG(14:0/20:2(11Z,14Z)/0:0)","LysoPE(22:5(4Z,7Z,10Z,13Z,16Z)/0:0)","L-Tryptophan","7-Methylhypoxanthine","Methyl L-leucinate","2-Methyl-1-butene","3-Methyl sulfolene","Niacinamide","Bergaptin","Myristoleoylcarnitine","[1-(3,3-Dimethyloxiran-2-yl)-3-[(8S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3-oxo-1,2,5,6,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-17-yl]butyl] acetate","Aspartyl-Leucine","Serotonin","6-Keto-decanoylcarnitine","PC(20:5(5Z,8Z,11Z,14Z,17Z)/P-18:1(11Z))","Succinic acid, sulfo-, 1,4-dioctyl ester","xi-5-Dodecanolide","Sanguinarine","Glycitin","Tetraethylene glycol monododecyl ether","LysoPC(18:1(9Z)/0:0)","Cholesterol","Cholestenone","Pro-leu","Valylmethionine","Pentaporphyrin I","Pentaethylene glycol","MG(0:0/24:6(6Z,9Z,12Z,15Z,18Z,21Z)/0:0)","Hexylamine","Niranthin","L-Valine","Uracil","L-prolinamide","Allyl undecylenate","8-HETE","L-Kynurenine","Creatine","Citranaxanthin","Threonylleucine","DG(14:1(9Z)/22:2(13Z,16Z)/0:0)","Phytosphingosine","Oleoylcarnitine","SM(d18:1/18:0)","Cytosine","Flurothyl","1-Naphthyl isocyanate","2-Acetylthiazole","Cedranoxide","Glycyl-Isoleucine","Asparaginyl-Phenylalanine","Bexarotene","Octinoxate","Abiraterone","2-Methoxy-1,4-benzoquinone","Valylleucine","LysoPC(24:0/0:0)","LysoPA(18:1(9Z)/0:0)","Lup-20(29)-en-3-ol","12-Hydroxy-12-octadecanoylcarnitine","Glutaminylphenylalanine","2,6-Di-tert-butylbenzoquinone","4-Methoxy-1-naphthol","Spermine","Pyridoxine hydrochloride","9-Hexadecenoylcarnitine","LysoPC(18:2(9Z,12Z)/0:0)","Hypoxanthine","(+)-1,2-Epoxyneomenthyl acetate","Isoleucyl-Serine","N-Methyl-a-aminoisobutyric acid","L-Arginine","Desmosterol","LysoPC(0:0/18:0)","Pivagabine","(4S,8R)-8,9-Dihydroxy-p-menth-1(6)-en-2-one","methiothepin","Putrescine","N8-Acetylspermidine","Ergosine","Croscarmellose","cis-3-Hexenyl trans-2-hexenoate","4-Hydroxycyclohexylcarboxylic acid","MG(16:1(9Z)/0:0/0:0)","N6,N6,N6-Trimethyl-L-lysine","PC(14:0/18:0)","Methyl 2-amino-3-(1H-indol-3-yl)propanoate","L-Glutamic acid","p-Octopamine","3-Hydroxy-cis-5-octenoylcarnitine","(S)-5'-Deoxy-5'-(methylsulfinyl)adenosine","Homocitrulline","15(S)-HPETE","1-Octanethiol","Octaethyleneglycol monododecyl ether","Adenine","9,12-Hexadecadienoylcarnitine","Threonic acid","MG(0:0/14:1(9Z)/0:0)","Bis(2-ethylhexyl) phthalate","Nicotinuric acid","LysoPC(16:0/0:0)","(2R)-2-{[(9Z)-Hexadec-9-enoyl]oxy}-3-hydroxypropyl 2-(trimethylazaniumyl)ethyl phosphate","Glycerol tripropanoate","PE(20:1(11Z)/18:2(9Z,12Z))","L-Serine","3-Hydroxybenz[a]anthracene","Lumichrome","Glycyl-Phenylalanine","Serylleucine","PE(20:4(8Z,11Z,14Z,17Z)/P-16:0)","Vanilpyruvic acid","2-Pyrrolidinone","Methylimidazoleacetic acid","Methyl l-phenylalaninate","9-Hydroxy-10-O-D-glucuronoside-12Z-octadecenoate","Allophanic acid","N-gamma-Glutamylcysteine ethyl ester","1-Methylpyrene","Ethyl isothiocyanate","Aminovaleric acid betaine","Vitamin A","PS(15:0/16:0)","Ethylbenzene","beta-Glycerophosphoric acid","Melibiose","20-Hydroxyeicosatetraenoic acid","Anserine","LysoPE(18:1(9Z)/0:0)","3-Amino-2-oxazolidone","12-Hydroxy-13-O-D-glucuronoside-octadec-9Z-enoate","3-Methylhistidine","Caffeine","Xylulose 5-phosphate","cis-3-Hexenyl butyrate","2-Aminopyridine","Hydrogen carbonate","PC(2:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))","Propionic acid","Pentadecadienoic acid","4-Deoxyphysalolactone","Debrisoquine","Heptaethylene glycol","Aconine","Tryptophyl-Isoleucine","5,6-DHET","L-Methionine","Pergolide","Thioridazine","Dihydrouracil","Talipexole","(22E, 24x)-Ergosta-4,6,8,22-tetraen-3-one","N,N-Dimethyldodecylamine","(13R,14R)-7-Labdene-13,14,15-triol","Caffeoylcycloartenol","2-Hydroxylauroylcarnitine","Glycerophosphocholine","PC(14:0/14:0)","PA(19:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))","3-Hydroxy-9-hexadecenoylcarnitine","(¡À)-2-Methylbutanal","Varenicline","Cholesta-4,6-dien-3-one","PE-NMe(16:0/16:0)","Tetrazepam","Glycyltyrosine","MG(0:0/18:2(9Z,12Z)/0:0)","myo-Inositol","2-Aminobenzimidazole","Tridemorph","4-Hepteneoylglycine","Pyroglutamic acid","Dichloromethylene","2-Methylpropyl acetate","Cholyllysine","Ginsenoyne D","Pyridoxamine","Succinylacetone","LysoPE(20:3(11Z,14Z,17Z)/0:0)","Frangulanine","PC(P-18:0/18:1(9Z))","2-Oxoarginine","L-Acetylcarnitine","Tyrosyl-Tyrosine","PA(8:0/22:6(5Z,8E,10Z,13Z,15E,19Z)-2OH(7S, 17S))","4-Chloro-2-nitrobenzylalcohol","Butanal","Androsterone","PS(15:0/20:5(5Z,8Z,11Z,14Z,17Z))","(3E,5Z)-1,3,5-Heptatriene","Decanoylcarnitine","PA(18:1(11Z)/22:2(13Z,16Z))","L-Glutamine","2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol","4-Methylpentanoylcarnitine","Tyrosyl-Threonine","2,3-Dimethyl-5,6-dithia-bicyclo[2.1.1]-hexane-5-oxide","Choline","Indane","N-Acetyl-L-alanine","Acetylcholine","2-Hepteneoylglycine","L-Threo-3-Phenylserine","Leucylphenylalanine","Dibenzylamine","Kyotorphin","Dibutyl phthalate","Dimethylurea","Methionyl-Leucine","Oleyl alcohol","Brassica oleracea Alkaloid","(Z)-1,3-Octadiene","Hydroxy-lacosamide","6-Oxopiperidine-2-carboxylic acid","1,2-Dilauroyl-sn-glycero-3-phosphocholine","Estreptoquinasa","LysoPE(18:2(9Z,12Z)/0:0)","Phytocassane B","Leucylalanine","1-Acetylproline","2-Piperidinone","PC(14:0/16:0)","Gluconic acid","LysoPE(16:0/0:0)","Cocaethylene","PC(15:0/22:5(4Z,7Z,10Z,13Z,16Z))","3,5-Di-tert-butyl-4-hydroxybenzaldehyde","Phosphorylcholine","N1-Methyl-2-pyridone-5-carboxamide","Cyclohexene","Palmitoylcarnitine","Aloxistatin","Losmapimod","Alanyllysine","LysoPC(15:0/0:0)","Histamine","PC(P-16:0/20:3(5Z,8Z,11Z))","LysoPC(20:4(5Z,8Z,11Z,14Z)/0:0)","alpha,alpha-Dimethylanisalacetone","LysoPC(20:0/0:0)","LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)","Chenodeoxycholylarginine","Dimethyl sulfoxide","Isoleucyl-Methionine","Diosgenin","DG(18:1(12Z)-O(9S,10R)/i-19:0/0:0)","Hexanethioic acid S-propyl ester","4'-Methylacetophenone","DG(2:0/0:0/LTE4)","Heptadecanoyl carnitine","3-hydroxyoctanoyl carnitine","Corynoxeine","2,2,6,7-Tetramethylbicyclo[4.3.0]nona-1(9),4-diene-7,8-diol","Methionine sulfoxide","2,5-Dimethyl-4-ethoxy-3(2H)-furanone","Normetanephrine","Phthalic anhydride","3-Hydroxybutyrylcarnitine","Nutriacholic acid","Taurodeoxycholic acid","Cer(d16:1/LTE4)","Threonylphenylalanine","Oxonic Acid","Octadecyl fumarate","PE(16:0/18:1(9Z))","Pyrrolidine","Piperidine","LysoPC(22:5(7Z,10Z,13Z,16Z,19Z)/0:0)","Serylphenylalanine","PA(16:1(9Z)/24:1(15Z))","Monoelaidin","Toluene","Chloromethyl chloroformate","Diisopropanolamine","PC(14:0/14:1(9Z))","Phosphocreatine","4-(4-Nitrobenzyl)pyridine","2-Methylfuran","N-Demethyltramadol","5-Hydroxy-L-tryptophan","LysoPC(18:3(9Z,12Z,15Z)/0:0)","delta-Valerolactone","Mestranol","Aritmina"],"additional_accession":[]},"is_claimable":false,"name":"Beinaglutide modulates abdominal subcutaneous adipose tissue microenvironment and lipid metabolism in diet-induced obese mice: a multi-omics analysis","description":"Beinaglutide (BN), a recombinant human glucagon-like peptide-1 receptor agonist, exhibits beneficial effects on obesity and metabolic disorders; however, its influence on obesity-related adipose tissue alterations and associated molecular changes remains unclear. In this study, C57BL/6J mice underwent a high-fat diet (HFD) for 12 weeks to induce obesity, followed by a 7-week treatment with BN. Evaluations of metabolic phenotypes, serum biochemical parameters, adipose tissue morphology, and multi-omics profiles of abdominal subcutaneous adipose tissue were conducted through transcriptomic, proteomic, and untargeted metabolomic analyses. BN treatment resulted in reduced body weight gain, improved glucose tolerance, partial amelioration of elevated liver enzyme levels, decreased weights of selected adipose depots, and attenuation of HFD-induced adipocyte hypertrophy.","dates":{"publication":"2026-09-23","submission":"2026-09-13"},"accession":"MTBLS15659","cross_references":{"HMDB":["HMDB0242113","HMDB0015180","HMDB0243598","HMDB0000626","HMDB0000634","HMDB0304623","HMDB0035795","HMDB0040305","HMDB0062324","HMDB0257261","HMDB0244840","HMDB0001452","HMDB0259275","HMDB0040552","HMDB0257360","HMDB0253573","HMDB0000491","HMDB0003466","HMDB0247399","HMDB0240507","HMDB0033536","HMDB0245159","HMDB0029532","HMDB0000619","HMDB0036833","HMDB0007853","HMDB0012958","HMDB0062336","HMDB0251013","HMDB0014324","HMDB0256696","HMDB0041307","HMDB0030862","HMDB0000518","HMDB0000172","HMDB0039024","HMDB0259764","HMDB0000506","HMDB0040508","HMDB0038352","HMDB0029990","HMDB0000661","HMDB0000653","HMDB0259897","HMDB0000622","HMDB0037609","HMDB0030180","HMDB0034081","HMDB0062310","HMDB0000746","HMDB0240605","HMDB0000951","HMDB0011518","HMDB0011512","HMDB0000191","HMDB0240600","HMDB0240602","HMDB0249157","HMDB0002639","HMDB0010379","HMDB0258742","HMDB0240604","HMDB0114773","HMDB0061698","HMDB0011525","HMDB0060526","HMDB0242693","HMDB0000156","HMDB0061695","HMDB0010393","HMDB0035480","HMDB0010396","HMDB0010392","HMDB0036303","HMDB0061693","HMDB0240261","HMDB0004948","HMDB0252848","HMDB0003178","HMDB0040008","HMDB0304403","HMDB0240608","HMDB0004953","HMDB0008839","HMDB0008928","HMDB0000700","HMDB0240617","HMDB0010169","HMDB0015687","HMDB0115530","HMDB0008971","HMDB0115528","HMDB0008938","HMDB0115076","HMDB0009060","HMDB0008994","HMDB0004971","HMDB0007870","HMDB0000306","HMDB0012358","HMDB0008979","HMDB0000500","HMDB0009103","HMDB0008946","HMDB0013404","HMDB0009070","HMDB0007935","HMDB0115436","HMDB0009004","HMDB0007874","HMDB0001232","HMDB0007969","HMDB0000564","HMDB0009096","HMDB0012402","HMDB0116750","HMDB0012391","HMDB0250932","HMDB0009111","HMDB0013413","HMDB0009078","HMDB0010163","HMDB0011151","HMDB0009012","HMDB0013426","HMDB0009011","HMDB0007884","HMDB0007975","HMDB0008006","HMDB0012431","HMDB0012362","HMDB0012435","HMDB0012390","HMDB0009441","HMDB0253680","HMDB0010165","HMDB0013407","HMDB0002432","HMDB0007982","HMDB0008141","HMDB0008016","HMDB0008138","HMDB0007983","HMDB0008105","HMDB0012406","HMDB0112671","HMDB0012395","HMDB0009399","HMDB0112584","HMDB0010167","HMDB0010166","HMDB0013409","HMDB0014491","HMDB0012387","HMDB0008147","HMDB0008081","HMDB0008048","HMDB0303539","HMDB0272143","HMDB0115731","HMDB0008023","HMDB0007991","HMDB0008148","HMDB0008115","HMDB0008049","HMDB0012428","HMDB0009790","HMDB0112617","HMDB0008156","HMDB0008123","HMDB0008057","HMDB0008313","HMDB0009845","HMDB0000730","HMDB0000448","HMDB0000174","HMDB0256275","HMDB0000694","HMDB0000956","HMDB0000292","HMDB0059811","HMDB0000161","HMDB0000816","HMDB0246393","HMDB0000226","HMDB0000459","HMDB0000462","HMDB0000678","HMDB0001954","HMDB0244002","HMDB0000190","HMDB0000321","HMDB0004291","HMDB0001024","HMDB0002107","HMDB0000748","HMDB0246532","HMDB0013222","HMDB0000289","HMDB0012289","HMDB0094722","HMDB0094718","HMDB0252849","HMDB0059933","HMDB0059936","HMDB0000511","HMDB0061684","HMDB0000701","HMDB0060015","HMDB0000072","HMDB0000893","HMDB0000812","HMDB0034252","HMDB0246305","HMDB0250108","HMDB0000044","HMDB0254499","HMDB0001015","HMDB0002043","HMDB0029415","HMDB0000714","HMDB0244108","HMDB0001889","HMDB0000755","HMDB0240280","HMDB0000017","HMDB0011657","HMDB0245462","HMDB0059712","HMDB0252378","HMDB0094731","HMDB0249720","HMDB0244269","HMDB0013010","HMDB0000786","HMDB0011635","HMDB0035291","HMDB0000784","HMDB0002203","HMDB0001138","HMDB0062181","HMDB0245001","HMDB0011745","HMDB0004812","HMDB0000094","HMDB0000821","HMDB0032575","HMDB0243978","HMDB0011756","HMDB0259922","HMDB0032901","HMDB0094804","HMDB0062775","HMDB0038631","HMDB0030989","HMDB0000832","HMDB0062473","HMDB0000792","HMDB0038440","HMDB0303331","HMDB0000671","HMDB0000060","HMDB0243955","HMDB0037776","HMDB0006029","HMDB0000764","HMDB0245431","HMDB0000682","HMDB0246026","HMDB0010727","HMDB0000114","HMDB0013279","HMDB0304061","HMDB0000888","HMDB0000387","HMDB0245035","HMDB0001352","HMDB0000350","HMDB0000011","HMDB0245906","HMDB0242762","HMDB0000729","HMDB0245492","HMDB0060026","HMDB0030921","HMDB0014118","HMDB0304326","HMDB0030723","HMDB0000139","HMDB0000933","HMDB0000806","HMDB0245050","HMDB0013267","HMDB0011734","HMDB0000623","HMDB0028920","HMDB0041789","HMDB0060324","HMDB0039102","HMDB0035407","HMDB0013067","HMDB0250690","HMDB0003345","HMDB0003119","HMDB0014862","HMDB0032866","HMDB0000273","HMDB0010730","HMDB0013286","HMDB0000767","HMDB0002327","HMDB0010731","HMDB0002261","HMDB0303726","HMDB0244132","HMDB0035358","HMDB0059661","HMDB0029762","HMDB0037197","HMDB0254614","HMDB0040032","HMDB0029519","HMDB0303804","HMDB0062363","HMDB0000220","HMDB0000444","HMDB0003229","HMDB0013272","HMDB0000872","HMDB0041954","HMDB0242558","HMDB0060917","HMDB0252528","HMDB0028823","HMDB0001530","HMDB0247933","HMDB0061122","HMDB0254305","HMDB0000112","HMDB0000195","HMDB0029051","HMDB0038165","HMDB0041287","HMDB0248258","HMDB0028704","HMDB0030972","HMDB0010733","HMDB0013317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