MetaboLights

application/xml

ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/m_MTBLS15659_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/m_MTBLS15659_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/s_MTBLS15659.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/a_MTBLS15659_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/a_MTBLS15659_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_N178.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_N184.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_T162.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_N179.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_N182.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_C60.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_N180.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_T156.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_T151.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_N185.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_N177.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_T159.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_F1926.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_C56.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_N176.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_F1926.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_T155.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_N181.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_N176.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_T156.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_C60.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_N182.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_T159.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_F1971.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_N185.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_N177.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_N180.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_C56.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_T162.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_F1971.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_N179.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_T155.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_N181.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/pos/Pos_N184.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_T151.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659/FILES/RAW_FILES/neg/Neg_N178.rawprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15659At the same time, the metabolites were identified by searching database, and the main databases were the HMDB (http://www.hmdb.ca/), Metlin ( https://metlin.scripps.edu/)MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase The LC-MS/MS analysis of sample was conducted on a Thermo UHPLC-Q Exactive HF-X system equipped with an ACQUITY HSS T3 column (100 mm × 2.1 mm i.d., 1.8 μm; Waters, USA) at Majorbio Bio-Pharm Technology Co. Ltd. (Shanghai, China). The mobile phases consisted of 0.1% formic acid in water:acetonitrile (95:5, v/v) (solvent A) and 0.1% formic acid in acetonitrile:isopropanol:water (47.5:47.5, v/v) (solvent B). The flow rate was 0.40 mL/min and the column temperature was 40℃. The injection volume was 3 μL.Beinaglutide modulates abdominal subcutaneous adipose tissue microenvironment and lipid metabolism in diet-induced obese mice: a multi-omics analysis.Lihua ZhouHebei North Universityadipose tissuemass spectrometry assay 50 mg solid sample was added to a 2 mL centrifuge tube and a 6 mm diameter grinding bead was added. 400 μL of extraction solution (methanol: water = 4:1 (v:v)) containing 0.02 mg/mL of internal standard (L-2-chlorophenylalanine) was used for metabolite extraction. Samples were ground by the Wonbio-96c ( Shanghai wanbo biotechnology co., LTD) frozen tissue grinder for 6 min (-10°C, 50 Hz), followed by low-temperature ultrasonic extraction for 30 min (5°C, 40 kHz). The samples were left at -20°C for 30 min, centrifuged for 15 min (4°C, 13000 g), and the supernatant was transferred to the injection vial for LC-MS/MS analysis.Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS15659Lihua Zhou. Hebei North University. 18770364141@163.com.The pretreatment of LC/MS raw data was performed by Progenesis QI (Waters Corporation, Milford, USA) software, and a three-dimensional data matrix in CSV format was exported. The information in this three-dimensional matrix included: sample information, metabolite name and mass spectral response intensity. Internal standard peaks, as well as any known false positive peaks (including noise, column bleed, and derivatized reagent peaks), were removed from the data matrix, deredundant and peak pooled.Treatment18770364141@163.comIn this study, C57BL/6J mice underwent a high-fat diet (HFD) for 12 weeks to induce obesity, followed by a 7-week treatment with BN. Evaluations of metabolic phenotypes, serum biochemical parameters, adipose tissue morphology, and multi-omics profiles of abdominal subcutaneous adipose tissue were conducted through transcriptomic, proteomic, and untargeted metabolomic analyses. MetabolomicsThermo Scientific Vanquish UHPLC SystemMetabolomicsObesityMus musculusuntargeted analysisinflammationThermo Scientific Q Exactive HF-Xadipose tissueBeinaglutideLipid MetabolismGLP-1 receptor agonistThermo Scientific Vanquish UHPLC SystemMetabolomicsObesityMus musculusuntargeted analysisinflammationThermo Scientific Q Exactive HF-Xadipose tissueBeinaglutideLipid MetabolismGLP-1 receptor agonistThe mass spectrometric data were collected using a Thermo UHPLC-Q Exactive HF-X Mass Spectrometer equipped with an electrospray ionization (ESI) source operating in positive mode and negative mode. The optimal conditions were set as followed: source temperature at 425℃; sheath gas flow rate at 50 arb; Aux gas flow rate at 13 arb; ion-spray voltage floating (ISVF) at -3500V in negative mode and 3500V in positive mode, respectively; Normalized collision energy , 20-40-60V rolling for MS/MS. Full MS resolution was 60000, and MS/MS resolution was 7500. Data acquisition was performed with the Data Dependent Acquisition (DDA) mode. The detection was carried out over a mass range of 50-1050 m/z.LysoPC(20:3(8Z,11Z,14Z)/0:0)Isoleucyl-TyrosineDL-2-Aminooctanoic acidVinylacetylglycineRiboflavinDG(22:4(7Z,10Z,13Z,16Z)/22:5(4Z,7Z,10Z,13Z,16Z)/0:0)Tryptophan 2-C-mannoside5-Octadecynoic acidTRIPHENYLPHOSPHINEAcetaldehyde oximePC(P-18:1(9Z)/18:0)Butyryl trihexyl citrate(S1)-Methoxy-3-heptanethiolAspartameGuaiacolStearoylcarnitineN-(3-Methylbutyl)acetamidePantothenolQuinolineAltretaminePemirolastL-HistidineTelocinobufaginLysoPC(0:0/18:2(9Z,12Z))PhenanthrenePolidocanol(2R)-2-[[(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acidCoumatetralylTRIPHENYL PHOSPHATEMethylphosphateCitrullinePE(18:1(9Z)/18:1(9Z))L-ProlinePhenolAntipyreneLabienoxime1-OleoylglycerophosphoserineInuline4-HydroxybenzaldehydeDG(14:1(9Z)/18:0/0:0)LysoPC(O-18:0/0:0)5-Hydroxyindoleacetic acidNorecasantalic acidindol-2-oneDicyclohexylamineCyclohexylamineCinnamic acidPhenylalanyltyrosinealpha-TocopherolToluene diisocyanateDuryl aldehydeGlycineUreidopropionic acidAlanylleucineMevalonic acidPhenylalanylglutamineStearoylethanolamidePC(O-16:0/20:5(5Z,8Z,11Z,14Z,17Z))3-Hydroxy-11Z-octadecenoylcarnitine3b,18b-3-Methoxy-11-oxo-12-oleanen-30-oic acid2,4,12-Octadecatrienoic acid isobutylamide[7]-ParadolLeucylleucinePC(P-16:0/18:2(9Z,12Z))1-PyrrolidineethanolMethyl (¡À)-2-methylpentanoateD-ononitolHexadecylamine2-Methylglutaric acidGinkgolide BLysoPC(18:0/0:0)PC(14:1(9Z)/15:0)gamma-Glutamylphenylalanine3-Hydroxyisovalerylcarnitine2-DecenoylcarnitineProline betaineGossypetin 8-glucuronide 3-glucosideLysoPE(16:1(9Z)/0:0)GlutaminylisoleucineAspartyl-TyrosineOleamideTiglylcarnitineMethylergonovineLidocainePantothenic acidTyrosyl-SerineAllolithocholic acidMethyl (2E,6Z)-dodecadienoateGuanosine2,6-Dimethoxy-4-(1-propenyl)phenolGlyceraldehyde 3-phosphate7-KetocholesterolXanthurenic acidTRIBUTYL PHOSPHATEDiphenyl phosphateBicifadineIndoleacetaldehydeOctanoylcarnitineSuccinyladenosinePhenylalanylalanine13-DocosenamideAsparaginylisoleucineTetradecanoylcarnitine3alpha-Tigloyloxytropane N-oxideOctaethylene glycolIndole-3-acetylglycineBrucinePalmitoleoylethanolamdeImatinibGlycylvaline(2E)-Piperamide-C5:1Alanylphenylalanine1,1,1-Trichloroheptane(3E,5E,8Z)-Deca-3,5,8-trienedioylcarnitineClozapine N-oxidePC(14:1(9Z)/P-16:0)AlanyltyrosineDG(2:0/6 keto-PGF1alpha/0:0)O-Demethylmetoprolol2-MethylindoleLysoPC(22:0/0:0)SerylmethionineUridineN-ButyrylglycineAsparaginyl-ValineDutasterideIbuproxam1-Methoxy-4-(2-propenyl)benzene(S)-2-PropylpiperidineSM(d18:0/16:1(9Z)(OH))(10Z)-Pentadec-10-enoylcarnitineOrnithinePindololPC(15:0/20:3(5Z,8Z,11Z))3-hydroxydecanoyl carnitine2-HydroxymyristoylcarnitineIsovalerylcarnitineIndoleGeranylcitronellolPS(15:0/18:0)BenzamideCysteinyl-Cysteine3-Hydroxymethylglutaric acidDibutylamine4-hydroxyhexanoylglycine6-Acetyl-2,2-dimethyl-2H-1-benzopyranN-[1-[[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methyl-2-(propanoylamino)pentanamideProlyl-Valine4-Hydroxybutyric acidL-Carnitine2-Hydroxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-oneLeucyl-GlutamateDihydrodioscorine13-OxoODEValylphenylalanineAdenosineAdenosine monophosphatePC(16:0/18:1(9Z))3-hydroxyhexadecanoyl carnitine3-Oxo-5beta-cholanoic acidN-Isobutyloctadeca-trans-2-trans-4-dienamide2,4-Hexadien-1-olPC(15:0/P-18:1(11Z))PhytalPA(18:2(9Z,12Z)/24:1(15Z))Asparaginyl-TyrosinePatulinEpomusenin BPro-IleLysoPC(0:0/20:4(5Z,8Z,11Z,14Z))Linoleic acidN-NITROSO-N-METHYLURETHANEIsoleucyl-LeucineDG(14:0/18:2(9Z,12Z)/0:0)L-TyrosinePC(16:0/18:2(9Z,12Z))Diisopropyl sulfide(2E,6Z)-2,6-Nonadien-1-Yl acetate1-NaphthylamineIsobutyryl-L-carnitineHomo-L-arginineValyltyrosine2,2'-Bioxirane5,7,3',4'-Tetrahydroxyflavanone 7-alpha-L-arabinofuranosyl-(1->6)-glucosideBenzoic acidBetonicineLysoPC(18:4(6Z,9Z,12Z,15Z)/0:0)ThioprolineFelbamateL-PhenylalaninePhenylalanylphenylalanineStearidonic acidValylvalineTrihexyphenidylgamma-GlutamyltyrosineAlanyltryptophanPhenforminAtractylenolide IIPC(14:0/20:2(11Z,14Z))SpermidineSphingosine5-(10,13-Nonadecadienyl)-1,3-benzenediolPhenylalanylvalineArginylphenylalaninegamma-GlutamylleucineTaurocholic acidN-Formylphenylalanine3-O-Methyl-a-methyldopa1,3-Butadiene7a-Hydroxy-5b-cholanic acid3-Indolebutyric acidPropionylcarnitineTyrosine methylester4-Nitrophenyl phosphateAspartylphenylalanineFuranofukininN-acetyl-L-2-aminoadipate(2-)Bakers yeast extract2-Butyl-1H-benzimidazoleSerylvalinePhenylacetaldehydeO-Linoleoylcarnitine9-Hydroxytridecyl docosanoateStigmastane-3,6-dione4-Formylaminoantipyrine(3Z,6Z)-3,6-Nonadien-1-ol(-)-ChimonanthineLysoPC(16:1(9Z)/0:0)Indole-3-carboxilic acid-O-sulphatePC(18:1(11Z)/P-18:1(9Z))TalbutalTetraethylene glycolPhenylalanylthreonineN-Lauroyl LeucineGuanineOctadecylamine5'-MethylthioadenosineCer(d18:1/16:0)LysoPE(22:4(7Z,10Z,13Z,16Z)/0:0)PC(18:0/18:2(9Z,12Z))m-CresolLysoPC(0:0/18:1(9Z))Dimethyl sulfone2-HydroxypyridineCreatinineIsoleucyl-Asparagine(2E,5Z,7E)-DecatrienoylcarnitinePA(20:4(5Z,8Z,11Z,14Z)/24:1(15Z))PS(15:0/18:2(9Z,12Z))(2Z)-6-Hydroxynon-2-enoylcarnitineXanthosineDothiepinPimelic acid1-O-Hexadecyl-sn-glycero-3-phosphocholine3,4-DiaminopyridineTG(14:0/14:0/18:3(6Z,9Z,12Z))GlycylleucineDiacetylAdenosine 2'-phosphateMG(i-17:0/0:0/0:0)DG(2:0/PGF1alpha/0:0)3-HydroxyhexanoylcarnitinePefloxacinMG(0:0/a-17:0/0:0)[rac]2-PhenylacetamideCimifuginSorbitan oleatePA(13:0/18:1(12Z)-O(9S,10R))DocosanamideLysoPC(20:1(11Z)/0:0)PC(14:0/P-18:1(11Z))HydroxycotinineCyclobarbitalHexaethylene glycolN-ethylmaleimidePurpaldPalmitic amideGlutamylvaline3-Amino-1-methyl-5H-pyrido[4,3-b]indoleArachidoyl Ethanolamide5-[(1-Iminoethyl)amino]-2-aminopentanoic acidLeucyl-GlutamineSM(d18:0/24:1(15Z)(OH))Pipecolic acid4-(2-Aminoethyl)benzenesulfonyl fluorideCopalic acidPhenylalanyltryptophangamma-GlutamylvalineSeryltryptophanDazometPA(16:1(9Z)/14:1(9Z))QuifenadineBetaineGlycerol phenylbutyrate4-Aminohippuric acidIndole-3-carboxaldehydeQUINUCLIDINECer(d18:1/18:0)FuranodienonePA(15:0/PGJ2)5alpha-PregnaneBeta-Tyrosine2,6-DimethylbenzenethiolAacocf3Aspartyl-Valine1,3-Dihydro-(2H)-indol-2-oneMG(0:0/15:0/0:0)N-[4-(Benzylamino)-3-cyanoquinolin-2-yl]-4-methoxybenzamideLysoPC(17:0/0:0)DyphyllineDiethyl L-malateLysoPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)Bethanidinegamma-GlutamylalanineCucurbic acidTryptopholIsoquinoline(R)-1,2-dimethyl-5,6-dihydroxy-tetrahydroisoquinolineL-Lysine20-COOH-leukotriene E4CapsiamideLysoPE(18:0/0:0)9,10-Epoxyoctadecenoic acid1-Methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine2-Aminoadipic acidDimethylaniline-N-oxideCysteinyl-ProlineTrimethylamine N-oxideProstaglandin I21-(2-Furanyl)-1-octanoneLysyl-PhenylalanineN-Docosahexaenoyl ArgininedesmethylclomipramineIsoleucyl-ThreonineSulfanilic acid6-Hexyltetrahydro-2H-pyran-2-oneSphinganine7alpha-Hydroxycholesterol2,4,6-TrimethylpyridineTyrosyl-LeucineMetoprololChloroform2-NaphthalenethiolThymine2-Hydroxy-4-trifluoromethyl benzoic acidOleoylethanolamidePC(18:0/18:0)Tridodecylamine3-Amino-4-hydroxybenzoic acidSarcosineMaltolL-beta-aspartyl-L-phenylalanineMethionyl-PhenylalaninePivalic acidDG(14:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)3,5,5-Trimethyl-2-cyclopenten-1-oneS-(2-Hydroxy-3-buten-1-yl)glutathione1-MethylhistaminePC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))Valpromide(3xi,5Z)-1,5-Octadien-3-olID116147a-Hydroxy-cholestene-3-oneDihydrocoriandrinArachidic acidPaullinic acidDG(18:1(9Z)/18:2(9Z,12Z)/0:0)Methyl benzoateUridine 3'-monophosphateO-Phosphoethanolamine5-DodecenoylcarnitineMannose 6-phosphateTrospiumCer(d17:1/LTE4)L-Threonine4-Hydroxy-2-butenoic acid gamma-lactonehydroquinidineKynurenic acidbeta-Alanine2-(Methylthio)ethanolL-LeucineTrigonelline(4-Hydroxybenzoyl)cholinePhenylalanylleucineSM(d18:1/18:1(9Z))PalmitoylethanolamideGlycerolStearaldehydePorphobilinogenPA(15:0/PGF1alpha)AjmalicineLeucyl-Valine4,8-Dimethyl-3,7-nonadien-2-one, cis-AICA-ribosideChloral hydratePA(18:4(6Z,9Z,12Z,15Z)/24:1(15Z))StyreneForskolinDichloromethane3-Methyl-1-butylamineSM(d18:1/14:1(9Z))PS(14:0/18:2(9Z,12Z))4-HydroxyprolineL-HistidinolCryptotanshinonePC(P-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))N,N-Didemethyl orphenadrine2,5-DimethylpyrazineArachidonoylcarnitineCarnosineLeucyl-GlycineAmydricaineDiisopropylamineLinoleamideL-NorleucineIcosa-8,11,14-trienoylcarnitineNicotine glucuronideDG(14:0/20:2(11Z,14Z)/0:0)LysoPE(22:5(4Z,7Z,10Z,13Z,16Z)/0:0)L-Tryptophan7-MethylhypoxanthineMethyl L-leucinate2-Methyl-1-butene3-Methyl sulfoleneNiacinamideBergaptinMyristoleoylcarnitine[1-(3,3-Dimethyloxiran-2-yl)-3-[(8S,10S,11S,14R)-11-hydroxy-4,4,8,10,14-pentamethyl-3-oxo-1,2,5,6,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-17-yl]butyl] acetateAspartyl-LeucineSerotonin6-Keto-decanoylcarnitinePC(20:5(5Z,8Z,11Z,14Z,17Z)/P-18:1(11Z))Succinic acid, sulfo-, 1,4-dioctyl esterxi-5-DodecanolideSanguinarineGlycitinTetraethylene glycol monododecyl etherLysoPC(18:1(9Z)/0:0)CholesterolCholestenonePro-leuValylmethioninePentaporphyrin IPentaethylene glycolMG(0:0/24:6(6Z,9Z,12Z,15Z,18Z,21Z)/0:0)HexylamineNiranthinL-ValineUracilL-prolinamideAllyl undecylenate8-HETEL-KynurenineCreatineCitranaxanthinThreonylleucineDG(14:1(9Z)/22:2(13Z,16Z)/0:0)PhytosphingosineOleoylcarnitineSM(d18:1/18:0)CytosineFlurothyl1-Naphthyl isocyanate2-AcetylthiazoleCedranoxideGlycyl-IsoleucineAsparaginyl-PhenylalanineBexaroteneOctinoxateAbiraterone2-Methoxy-1,4-benzoquinoneValylleucineLysoPC(24:0/0:0)LysoPA(18:1(9Z)/0:0)Lup-20(29)-en-3-ol12-Hydroxy-12-octadecanoylcarnitineGlutaminylphenylalanine2,6-Di-tert-butylbenzoquinone4-Methoxy-1-naphtholSperminePyridoxine hydrochloride9-HexadecenoylcarnitineLysoPC(18:2(9Z,12Z)/0:0)Hypoxanthine(+)-1,2-Epoxyneomenthyl acetateIsoleucyl-SerineN-Methyl-a-aminoisobutyric acidL-ArginineDesmosterolLysoPC(0:0/18:0)Pivagabine(4S,8R)-8,9-Dihydroxy-p-menth-1(6)-en-2-onemethiothepinPutrescineN8-AcetylspermidineErgosineCroscarmellosecis-3-Hexenyl trans-2-hexenoate4-Hydroxycyclohexylcarboxylic acidMG(16:1(9Z)/0:0/0:0)N6,N6,N6-Trimethyl-L-lysinePC(14:0/18:0)Methyl 2-amino-3-(1H-indol-3-yl)propanoateL-Glutamic acidp-Octopamine3-Hydroxy-cis-5-octenoylcarnitine(S)-5'-Deoxy-5'-(methylsulfinyl)adenosineHomocitrulline15(S)-HPETE1-OctanethiolOctaethyleneglycol monododecyl etherAdenine9,12-HexadecadienoylcarnitineThreonic acidMG(0:0/14:1(9Z)/0:0)Bis(2-ethylhexyl) phthalateNicotinuric acidLysoPC(16:0/0:0)(2R)-2-{[(9Z)-Hexadec-9-enoyl]oxy}-3-hydroxypropyl 2-(trimethylazaniumyl)ethyl phosphateGlycerol tripropanoatePE(20:1(11Z)/18:2(9Z,12Z))L-Serine3-Hydroxybenz[a]anthraceneLumichromeGlycyl-PhenylalanineSerylleucinePE(20:4(8Z,11Z,14Z,17Z)/P-16:0)Vanilpyruvic acid2-PyrrolidinoneMethylimidazoleacetic acidMethyl l-phenylalaninate9-Hydroxy-10-O-D-glucuronoside-12Z-octadecenoateAllophanic acidN-gamma-Glutamylcysteine ethyl ester1-MethylpyreneEthyl isothiocyanateAminovaleric acid betaineVitamin APS(15:0/16:0)Ethylbenzenebeta-Glycerophosphoric acidMelibiose20-Hydroxyeicosatetraenoic acidAnserineLysoPE(18:1(9Z)/0:0)3-Amino-2-oxazolidone12-Hydroxy-13-O-D-glucuronoside-octadec-9Z-enoate3-MethylhistidineCaffeineXylulose 5-phosphatecis-3-Hexenyl butyrate2-AminopyridineHydrogen carbonatePC(2:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))Propionic acidPentadecadienoic acid4-DeoxyphysalolactoneDebrisoquineHeptaethylene glycolAconineTryptophyl-Isoleucine5,6-DHETL-MethioninePergolideThioridazineDihydrouracilTalipexole(22E, 24x)-Ergosta-4,6,8,22-tetraen-3-oneN,N-Dimethyldodecylamine(13R,14R)-7-Labdene-13,14,15-triolCaffeoylcycloartenol2-HydroxylauroylcarnitineGlycerophosphocholinePC(14:0/14:0)PA(19:0/22:6(5Z,7Z,10Z,13Z,16Z,19Z)-OH(4))3-Hydroxy-9-hexadecenoylcarnitine(¡À)-2-MethylbutanalVareniclineCholesta-4,6-dien-3-onePE-NMe(16:0/16:0)TetrazepamGlycyltyrosineMG(0:0/18:2(9Z,12Z)/0:0)myo-Inositol2-AminobenzimidazoleTridemorph4-HepteneoylglycinePyroglutamic acidDichloromethylene2-Methylpropyl acetateCholyllysineGinsenoyne DPyridoxamineSuccinylacetoneLysoPE(20:3(11Z,14Z,17Z)/0:0)FrangulaninePC(P-18:0/18:1(9Z))2-OxoarginineL-AcetylcarnitineTyrosyl-TyrosinePA(8:0/22:6(5Z,8E,10Z,13Z,15E,19Z)-2OH(7S, 17S))4-Chloro-2-nitrobenzylalcoholButanalAndrosteronePS(15:0/20:5(5Z,8Z,11Z,14Z,17Z))(3E,5Z)-1,3,5-HeptatrieneDecanoylcarnitinePA(18:1(11Z)/22:2(13Z,16Z))L-Glutamine2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol4-MethylpentanoylcarnitineTyrosyl-Threonine2,3-Dimethyl-5,6-dithia-bicyclo[2.1.1]-hexane-5-oxideCholineIndaneN-Acetyl-L-alanineAcetylcholine2-HepteneoylglycineL-Threo-3-PhenylserineLeucylphenylalanineDibenzylamineKyotorphinDibutyl phthalateDimethylureaMethionyl-LeucineOleyl alcoholBrassica oleracea Alkaloid(Z)-1,3-OctadieneHydroxy-lacosamide6-Oxopiperidine-2-carboxylic acid1,2-Dilauroyl-sn-glycero-3-phosphocholineEstreptoquinasaLysoPE(18:2(9Z,12Z)/0:0)Phytocassane BLeucylalanine1-Acetylproline2-PiperidinonePC(14:0/16:0)Gluconic acidLysoPE(16:0/0:0)CocaethylenePC(15:0/22:5(4Z,7Z,10Z,13Z,16Z))3,5-Di-tert-butyl-4-hydroxybenzaldehydePhosphorylcholineN1-Methyl-2-pyridone-5-carboxamideCyclohexenePalmitoylcarnitineAloxistatinLosmapimodAlanyllysineLysoPC(15:0/0:0)HistaminePC(P-16:0/20:3(5Z,8Z,11Z))LysoPC(20:4(5Z,8Z,11Z,14Z)/0:0)alpha,alpha-DimethylanisalacetoneLysoPC(20:0/0:0)LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)ChenodeoxycholylarginineDimethyl sulfoxideIsoleucyl-MethionineDiosgeninDG(18:1(12Z)-O(9S,10R)/i-19:0/0:0)Hexanethioic acid S-propyl ester4'-MethylacetophenoneDG(2:0/0:0/LTE4)Heptadecanoyl carnitine3-hydroxyoctanoyl carnitineCorynoxeine2,2,6,7-Tetramethylbicyclo[4.3.0]nona-1(9),4-diene-7,8-diolMethionine sulfoxide2,5-Dimethyl-4-ethoxy-3(2H)-furanoneNormetanephrinePhthalic anhydride3-HydroxybutyrylcarnitineNutriacholic acidTaurodeoxycholic acidCer(d16:1/LTE4)ThreonylphenylalanineOxonic AcidOctadecyl fumaratePE(16:0/18:1(9Z))PyrrolidinePiperidineLysoPC(22:5(7Z,10Z,13Z,16Z,19Z)/0:0)SerylphenylalaninePA(16:1(9Z)/24:1(15Z))MonoelaidinTolueneChloromethyl chloroformateDiisopropanolaminePC(14:0/14:1(9Z))Phosphocreatine4-(4-Nitrobenzyl)pyridine2-MethylfuranN-Demethyltramadol5-Hydroxy-L-tryptophanLysoPC(18:3(9Z,12Z,15Z)/0:0)delta-ValerolactoneMestranolAritminafalseBeinaglutide modulates abdominal subcutaneous adipose tissue microenvironment and lipid metabolism in diet-induced obese mice: a multi-omics analysisBeinaglutide (BN), a recombinant human glucagon-like peptide-1 receptor agonist, exhibits beneficial effects on obesity and metabolic disorders; however, its influence on obesity-related adipose tissue alterations and associated molecular changes remains unclear. In this study, C57BL/6J mice underwent a high-fat diet (HFD) for 12 weeks to induce obesity, followed by a 7-week treatment with BN. Evaluations of metabolic phenotypes, serum biochemical parameters, adipose tissue morphology, and multi-omics profiles of abdominal subcutaneous adipose tissue were conducted through transcriptomic, proteomic, and untargeted metabolomic analyses. BN treatment resulted in reduced body weight gain, improved glucose tolerance, partial amelioration of elevated liver enzyme levels, decreased weights of selected adipose depots, and attenuation of HFD-induced adipocyte 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