MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/m_MTBLS15833_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/m_MTBLS15833_LC-MS_negative_hilic_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/m_MTBLS15833_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/a_MTBLS15833_LC-MS_negative_hilic.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/s_MTBLS15833.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/a_MTBLS15833_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/a_MTBLS15833_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO8_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT5_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/QC03_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/QC01_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO4_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO6_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO6_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO2_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO2_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO5_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO7_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO6_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO8_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO9_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT2_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT3_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT2_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT1_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO4_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/QC03_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/QC01_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT5_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO4_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO3_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO2_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO1_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT4_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT6_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/QC02_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT4_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO7_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT6_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO3_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO5_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO1_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO9_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT1_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT6_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO3_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT5_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT3_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT2_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT4_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO5_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/QC03_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/QC02_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/QC01_N.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT3_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO7_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO9_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO8_P.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/KO1_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/WT1_HN.mzMLftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833/FILES/DERIVED_FILES/QC02_HN.mzMLprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15833<p>Metabolites were identified and annotated based on chromatographic retention time and characteristic mass-spectrometric information, including precursor/product ion transitions, by comparison with an in-house metabolite database. Metabolite annotation was further supported, where available, by public metabolite databases including HMDB, KEGG, PubChem and ChEBI. For quantitative analysis, characteristic precursor-to-product ion transitions were monitored using MRM, and chromatographic peak areas were integrated using MultiQuant software.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phaseLiquid Chromatography MS - negative - hilic<p>Chromatographic separation was performed using a SCIEX ExionLC AD UPLC system with two complementary chromatographic methods. For reversed-phase separation in both positive and negative ion modes, a Waters ACQUITY UPLC HSS T3 column (100 × 2.1 mm, 1.8 μm) was used. Mobile phase A consisted of water containing 0.1% formic acid, and mobile phase B consisted of acetonitrile containing 0.1% formic acid. The gradient program was 0.0 min, 5% B; 2.0 min, 20% B; 5.0 min, 60% B; 6.0 min, 99% B; 7.5 min, 99% B; 7.6 min, 5% B; and 10.0 min, 5% B. For HILIC separation in negative ion mode, a Waters ACQUITY UPLC BEH HILIC column (100 × 2.1 mm, 1.7 μm) was used. Mobile phase A consisted of 80% acetonitrile, 10% water, and 10% methanol containing 20 mM ammonium formate, adjusted to pH 10.6 with ammonia, whereas mobile phase B consisted of 40% acetonitrile and 60% water containing 20 mM ammonium formate, adjusted to pH 10.6 with ammonia. The HILIC gradient program was 0.0 min, 5% B; 2.0 min, 20% B; 3.5 min, 70% B; 6.5 min, 95% B; 7.5 min, 95% B; 7.6 min, 5% B; and 10.0 min, 5% B. For both chromatographic methods, the flow rate was 0.4 mL/min and the column temperature was maintained at 40°C. Eluted metabolites were subsequently introduced into the mass spectrometer by electrospray ionization for MS/MS analysis.</p>ZEB1 Maintains Energy Metabolism to Sustain Cardiac Function Through Synergistic Regulation with TEAD1.Taiwei ChenDepartment of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University;heartmass spectrometry assay<p>Frozen heart tissues were homogenized using a tissue grinder at 30 Hz for 20 s. Subsequently, 400 μL of 70% methanol containing internal standards was added for metabolite extraction. Samples were vortexed/shaken at 2500 rpm for 5 min and incubated on ice for 15 min. After centrifugation at 12,000 rpm for 10 min, 300 μL of the supernatant was collected and stored at -20°C for 30 min. Samples were then centrifuged again at 12,000 rpm for 3 min at 4°C. Finally, 200 μL of the resulting supernatant was transferred to autosampler vials for UPLC-MS/MS analysis. Pooled quality-control (QC) samples were prepared and analyzed to monitor analytical stability and reproducibility throughout the metabolomic analysis.</p>Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS15833Taiwei Chen. Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University;. chentaiwei71@163.com.<p>Raw LC-MS/MS data were acquired using Analyst software (version 1.6.3). MRM chromatographic peaks were integrated and processed using MultiQuant software. Peak areas corresponding to individual metabolite-specific MRM transitions were extracted and used for relative metabolite quantification. Quality-control samples were used to monitor analytical stability and reproducibility. The resulting processed data matrix contained metabolite peak-area values for each biological sample and pooled QC sample.</p>Genotypechentaiwei71@163.com<p>Heart tissues were collected from cardiac-specific Zeb1 knockout (Zeb1 cKO) mice (n = 9) and Zeb1 fl/fl littermate controls (n = 6). Following collection, heart tissues were placed in individually labeled sample containers using clean laboratory instruments to minimize cross-contamination between samples. Tissues were rapidly frozen in liquid nitrogen immediately after collection and subsequently stored at -80°C until metabolomic sample preparation. No chemical stabilizers or preservatives were added during tissue storage. Sample identity and genotype were documented throughout collection, storage, and subsequent processing. Samples were maintained under consistent frozen-storage conditions prior to metabolite extraction.</p>MetabolomicsMetabolomicsheart failureMus musculusZEB1SCIEX ExionLC ADuntargeted analysisAB SCIEX QTRAP 6500cardiomyopathyTEAD1heartMetabolomicsheart failureMus musculusZEB1SCIEX ExionLC ADuntargeted analysisAB SCIEX QTRAP 6500cardiomyopathyTEAD1heart<p>Metabolomic analysis was performed using an ABI SCIEX 6500 QTRAP LC-MS/MS system equipped with an electrospray ionization (ESI) source. Metabolites separated by reversed-phase HSS T3 chromatography were analyzed in both positive and negative ion modes, whereas metabolites separated by HILIC chromatography were analyzed in negative ion mode. Targeted metabolite detection and relative quantification were performed using multiple reaction monitoring (MRM). Precursor ions were selected in Q1, subjected to collision-induced dissociation, and characteristic product ions were monitored in Q3. Declustering potential (DP) and collision energy (CE) were optimized individually for metabolite-specific MRM transitions rather than applying uniform values to all metabolites. ESI source parameters, including ion spray voltage, source temperature, curtain gas, ion source gas 1, and ion source gas 2, were optimized separately for positive- and negative-ion acquisition to achieve stable electrospray ionization and reproducible metabolite detection. Data were acquired using Analyst software (version 1.6.3). Metabolite identification was based on chromatographic retention time and characteristic precursor/product ion transitions by comparison with an in-house metabolite database. MRM chromatographic peaks were integrated and processed using MultiQuant software, and integrated peak areas were used for relative metabolite quantification.</p>Ile-ThrAspartylcysteine2-Methyl-d-erythritol 2,4-cyclodiphosphateD-Tartaric acidManghaslinGuanosine-5'-triphosphateXanthosine-5'-monophosphatecis-4,10-13,16-Docosatetraenoic Acid methyl esterDl-3,4-Dihydroxymandelic AcidTilirosideIsobutyl-decanoateLuteoskyrinGamma-CaprolactoneCaffeic Acid2-hydroxyphenylacetic acidAdenophostin aCis-ACCP15(S)-Hydroxyeicosatrienoic acidTetracosanoic acidLys-ValQuercetin 3-sulfateSpongouridine1-Methylxanthine(3S,4S)-4-(Benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydrobenzo[g]chromene-5,10-dione1-beta-D-Galactosylsphingosine2-Amino-5-phosphonopentanoic acidMesaconic acid7-bromo-3,3a,6,8b-tetramethyl-2,3-dihydro-1H-cyclopenta[b]benzofuranNaringenin chalcone[(2R,3S,4S,5R)-3,4,5,6-tetrahydroxytetrahydropyran-2-yl]methyl hydrogen sulfateVanillic AcidPiperidine acidTrans-4-Hydroxy-L-Prolinem-Chlorobenzoic acidGlycinePhthalic AcidVal-Ala2'-O-MethylguanosineN-Acetyl-leu-leu-tyr-amideL-TheanineN-PhenylacetylglycineLamivudineSer-SerUridine 5'-diphosphoglucuronic acidNorlaudanosolineAllopregnanolone3,5-DinitrobenzamideArabinonic acid3-(2-Hydroxyphenyl)propanoic acidIsotretinoin2,4,7,8,9-Pentachloro-3-dibenzofuranoltrans-1,4-Dichloro-2-butenegamma-Glu-GlnL-ArabitolPC(18:2(9Z,12Z)/16:1(9Z))1-StearoylglycerophosphoglycerolAsp-Lys2'-Deoxyguanosine-5'-diphosphatePC(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))CitrateDihydropteroate2,4,5-Trichlorophenoxyacetic acidO-Phospho-L-tyrosine3,3'-Diamino-4,4'-dihydroxydiphenyl SulfonePregnenolone monosulfate3,5-DichlorocatecholPotassium acetateAsp-Ser3-Furoic acidDiethyl-phosphateAmifostineHomocitric acid2-dehydro-D-gluconic acid3-N-Methyl-L-HistidineBeta-Pseudouridinedelta-(L-2-Aminoadipyl)-L-cysteinyl-D-valineUridineUridine 5-MonophosphateRetinalPropylene glycolMalonic acidFumigaclavine CCoM-S-S-CoBN-AcetylthreonineN-hydroxy-L-valine(S)-3,5-Dihydroxyphenylglycinealpha-Kosin11-Cis-RetinolFumonisin b1(+/-)15-HETE6-hydroxyhexanoic AcidGlucuronic AcidAsp-GlyDiethanolamine2,4-Pyridinedicarboxylic acidAcarboseAdenosineDocosapentaenoic acid (22n-6)1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholineFumaric Acid3-deazauridine3-DehydroshikimateFFA(16:1)His-Ile4-hydroxyisophthalic acidL-TyrosineSubericacid3-SulfocholyltaurineEthylnitronatePC(16:0/20:4(5Z,8Z,11Z,14Z))13-methylmyristic acid2-Isopropylmalate5-FormyluracilPhenylpyruvic acidAurapteneAscorbic acidMyristelaidic acidTrp-GlyGlucose(S)-Mevalonic acid-5-pyrophosphateThioguanineDocosahexaenoic acidN6-Acetyl-L-LysineThr-SerErythritolGuanabenzStrictosidineLeu-AlaTaurocholic acid(+)-cis-abscisic aldehyde3-Oxalomalic acidEthyl fumarate3'-DeoxyguanosineDocosadienoate (22:2n6)LPE(18:0/0:0)RibitolHis-SerL-IditolL-Cystathionine(2-Hydroxyethyl)phosphonic acidDiospyrinPotassium bicarbonateDiethyl-Glutarate(2E)-but-2-ene-1,2,3-tricarboxylic acidTrehaloseUridine 5'-Diphosphate2-hydroxyhexadecanoic acidGuanine8,11,14-Eicosatrienoic acid8-OH-Ado6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-oneN-Acetyl-L-TyrosineCreatinine2-Amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoateCreatine phosphateFructose-6-phosphate3-alpha,20-alpha-Dihydroxy-5-beta-pregnane 3-glucuronide(20S)-20-Hydroxypregn-4-en-3-one1,6-di-O-phosphono-D-fructose5-Hydroxyuridine2'-Deoxycytidine-5'-Monophosphate3-Aminopentanedioic acidMetanil yellow4'-ChloroacetoacetanilidePyridoxine 5'-PhosphateTiglic acid8-bromo-cGMPCrispolideItaconic acid2-ChlorooxiraneL-Alanine2'-DeoxyuridineAsn-SerCDP-ethanolamineJasmonic acid3-Methyl-2-Oxobutanoic AcidIle-ValAsn-Lys1,1-DichloroethaneHeneicosanoic acidCinncassiol C1 19-glucosideSodium cyclamateObamegineDehydroascorbic acidLycodine3,3'-Bipyridine-2,2',5,5',6,6'-hexolIndole-3-lactic acidDL-2-hydroxystearic acidSucrose 6'-monophosphatePalmitoyl 3-carbacyclic Phosphatidic Acid5alpha-Androstan-17beta-ol propionateAdenylosuccinic acid1-MethylhistidineUDP-D-galactoseDinitrostilbenedisulfonic acid5'-Chloro-5'-deoxyadenosine2-Aminoethanesulfinic AcidDichlorophenyl-bis-triazolylpropanolArg-IleVal-LeuL-3-sulfolactaldehydegamma-Glu-LysTriptophenolideLeukotriene D4-d5PhosphatidylserineBrowniine1-Palmitoyl-sn-glycero-3-phosphoethanolamineIsosorbide mononitrateN-octanoylsphingosine 1-phosphateD-Glucose 6-PhosphateGlycerol 3-Phosphate2-Octenoic acidD-Ribulose 1,5-bisphosphatealpha-Ketoglutaric Acid (alpha-KG)D-Ribose(1R,2S,5S,6S)-2-(3-carboxypropanoyl)-5-[(1-carboxyvinyl)oxy]-6-hydroxycyclohex-3-ene-1-carboxylic acidSarcosine1-Methyluric AcidLactic acid6,7-Benzocoumarin7-Methyluric AcidElatinTaurinePC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))Embelin2-Benzylsuccinic acidAllantoinDL-2-(2,4-Dinitroanilino)-4-(methylsulphinyl)butyric acidGlucaric acid3-Hydroxy-2,4-dioxopentyl phosphate6-MethylaminopurinePro-Leu2-HydroxyethanesulfonateTetralithium 3-hydroxy-3-methyl-5-{[(phosphonatooxy)phosphinato]oxy}pentanoateCytochalasin PphoL-SaccharopinePhosphoenolpyruvate3-Amino-4-Hydroxybenzoic AcidN-Acetyl-leu-leu-tyrPyridoxal3-Ureidopropionate2'-DeoxyinosineGuanidineacetic Acid(2S)-2-[2-[(5R,6R,7S,9S,11R,16R,18S,19S)-19-acetamido-6-[(3S)-3,4-dicarboxybutanoyl]oxy-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid(E)-GuggulsteroneTyrosolD-erythro-3-methylmalic acidBis(2,5-dimethyl-3-furanyl) disulfideHippomane factor M1Ribonic acidO-Phospho-L-threonined-Myo-inositol 4-monophosphate ammonium salt2'-O-methylinosine10E,12Z-Octadecadienoic acid1-MethylguanosineUreidoacrylic acidD-threo-Isocitric acid3,5-Dichlorosalicylic acid2-Naphthalenesulfonic acidIdebenone1,1-Dimethoxynonane2-(10-Heptadecenyl)-6-hydroxybenzoic acidGlycolic acidZoledronic acid(E)-3-(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoic acidL-Tryptophan4-Methoxyglucobrassicin1-Heptadecanoyl-glycero-3-phosphatePrimidone3-((6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenolLPA(i-20:0/0:0)2-Hydroxy-6-Aminopurine2-Furylmercury chlorideSer-ArgNalpha-Acetyl-L-Arginine3-(Methylthio)propionic acidInosine 5'-triphosphate2-methyl citric acidNalpha-Acetyl-L-glutamineCotinine-N-Oxidecis-3,4-LeucopelargonidinUracilGlu-Glu2,4-Hexadienoic acid[5-(Aminomethyl)-3-furyl]methyl diphosphate3-Indolepropionic Acid1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineUDP-4-dehydro-6-deoxy-D-glucoseAla-IleAsn-PheAlanylcysteineCreatineAlizarin5-Hydroxyindole-3-Acetic AcidChlorzoxazoneIsoallolithocholic acidD-galactaro-1,5-lactoneArg-SertetraHCAGlu-HisVanillyl AlcoholMucic AcidIsopentenyl pyrophosphateCytidine-5'-triphosphateL-Cystine5-hydroxymethyl-2'-deoxycytidineEstra-1,3,5(10)-triene-3,16alpha-diol, dipropionate4,6-Diamino-5-formamidopyrimidineSuccinic AcidSer-Val16-DehydroprogesteroneArabitolHypoxanthine17-O-AcetylnorajmalinePyrroloquinoline QuinoneTungstic acid1-Eicosanoyl-glycero-3-phosphateSelenomethionineRugulosingamma-Glu-AlaThr-IlePrepacifennol epoxideArabinoseAflatoxin-M1L-Cysteine8-Hydroxyeicosa-9,11,14-trienoic acidSalanninThr-HisL-HomocystineBiotin-XX-HydrazideCitraconic AcidD-Glucono-1,5-LactoneAdenosine 5'-Diphosphate(ADP)GuloseAdenine1-(2,6-Dihydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)propan-1-one2-Hydroxy-3,5-dinitrobenzoic acidThreonic acid2-Hydroxy-3-Methyl Butanoic AcidL-Epicatechin1,6-di-O-phosphono-beta-D-fructofuranoseBacteriochlorophyllide b(2R)-2-amino-3-[(Z)-N-hydroxy-C-(1H-indol-3-ylmethyl)carbonimidoyl]sulfanylpropanoic acidArg-ThrInosineL-SerineN-Acetyl-S-(2-hydroxyethyl)-L-cysteine3-Carboxy-1-hydroxypropylthiamine diphosphateLumichromeN-Acetyl-L-phenylalanine3-Hydroxyglutaric acid2-Pyrrolidineacetic acid3-(Methylthio)methylthiopheneThiamine-MonophosphateFirefly luciferinMelibioseEllagic acid(3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acidUreidosuccinic acid3,5-Dihydroxybenzoic acid3-Hydroxy-3-Methyl Butyric AcidAconitic AcidTyraminePyridine-3,4-dicarboxylic acidL-CitrullineD-Mannose 6-phosphateN-(2-Amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamideCarboxymethanesulfinyl-acetic acidThr-AspGlu-Glu-Met(2E,4Z)-2-hydroxymuconic acidUDP-glucoseO-PhosphorylethanolamineDicambaIle-AlaCis-4-Hydroxy-L-Proline4-(2-Hydroxyethyl)-1-piperazine ethanesulfonic acidBovinic acid1-(11Z,14Z-eicosadienoyl)-glycero-3-phosphatePro-valN-AcetylornithineSuccinic acid semialdehydeGanodosterone4-Hydroxy-3-methylbenzoic acidPyroglutamic acidBut-1-ene-1,2,4-tricarboxylic acidS-Glutathionyl-L-cysteineArg-LeuAdenosine 5'-triphosphate(ATP)Hydroxyphenyllactic acidN-methyl-4-aminobutyric acidCoriolic acidDl-ThreitolN-MethylnicotinamideIsomaltoseXanthine[(2R)-2-(10-methylundecanoyloxy)-3-phosphonooxypropyl] 12-methyltridecanoateL-Glutamine10Z,13Z-nonadecadienoic acidHis-Leup-Tolyl SulfateAla-glnPhenyl acetateOroxylin AThymidineDiphenylamine4-Hydroxyphthalic acid3-dehydro-L-gulonic acid 6-phosphateLactitolMalic acid3-Phosphoglyceric acid5-(4-Acetoxybut-1-ynyl)-2,2'-bithiophene2,3-dimethylmaleic-anhydrideMoniliforminN3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamineMaltoseUndecanedioic acidVal-GlyUridine triphosphate(UTP)Gly-Pro2-methyl-4-(sulfooxy)but-2-enoic acidN-Acetylneuraminic Acid(SA)Asn-AspAsn-Asn3,3',4'5-TetrahydroxystilbeneDi-trans,poly-cis-pentaprenyl diphosphateGuanosine-5'-diphosphateOrotic AcidRaffinoseChlorohydroquinone(Aminomethyl)phosphonic acidP-Aminobenzoate2-(Dimethylamino)Guanosine(1R,3R,8R,12S,13R,17R,18Z,20Z,24R,25S,26S)-12-hydroxy-17-[(1R)-1-hydroxyethyl]-5,13,25-trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,18,20-triene-26,2'-oxirane]-11,22-dione3-Hydroxyphenacetin phosphateFluorofelbamategamma-Glu-CysInositol 1-phosphate3-Guanidinopropionic acidCyclo(Tyr-Leu)DethiobiotinSorbifolin5-(2-Azaniumylethyl)-2-hydroxyphenyl sulfateMaltohexanose3-Amino-5-hydroxybenzoic acidalpha-D-glucose-1-phosphateTrp-AspLactose5-Hydroxypyridine-2(1H)-oneAmylotetraoseDeoxycytidine2-Hydroxy-2-Methyl Butyric acid(Rs)-Mevalonic AcidLeu-GlyfalseZEB1 Maintains Energy Metabolism to Sustain Cardiac Function Through Synergistic Regulation with TEAD1Metabolic reprogramming plays a critical role in heart failure (HF), but its regulatory mechanisms remain incompletely understood. Zinc finger E-box binding homeobox 1 (ZEB1), a transcription factor initially identified as a regulator of epithelial-mesenchymal transition, has recently been implicated in metabolic regulation. Here, we show that ZEB1 expression is reduced in failing cardiomyocytes. Cardiomyocyte-specific deletion of Zeb1 leads to progressive HF with impaired glycolysis and fatty acid metabolism. Mechanistically, ZEB1 interacts with TEA domain transcription factor 1 (TEAD1) to activate metabolic genes, including pyruvate kinase muscle isozyme 1 (PKM1) and acetyl-CoA acyltransferase 2 (ACAA2), which regulate glycolysis and fatty acid β-oxidation, respectively. Loss of Acaa2 aggravates cardiac hypertrophy and stress-induced mitochondrial dysfunction. Acetate supplementation restores cardiac function in Zeb1-deficient mice, whereas ZEB1 overexpression improves pressure overload- and doxorubicin-induced HF. These findings identify the ZEB1-TEAD1 axis as a regulator of cardiac metabolic homeostasis and a potential therapeutic target for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