MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/m_MTBLS15900_LC-MS_positive_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/m_MTBLS15900_LC-MS_negative_reverse-phase_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/s_MTBLS15900.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/a_MTBLS15900_LC-MS_positive_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/a_MTBLS15900_LC-MS_negative_reverse-phase.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100596.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/Blank2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC_pos_70-300.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100603.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/Blank1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100600.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100604.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100597.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC_neg_70-300.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100605.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC_pos_590-1050.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/RTQC_20260529085640.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100601.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/Blank4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100598.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC_neg_290-600.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/Blank3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100606.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100595.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC_neg_590-1050.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC_neg_70-1050.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100599.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/WK-2026060100602.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC_pos_70-1050.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900/FILES/RAW_FILES/QC_pos_290-600.rawprimary200OKftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS15900<p>Peak extraction was performed using XCMS software, adduct ion annotation using CAMERA, and primary identification using metaX software. Metabolites were annotated by combining retention time (RT) and m/z data, matching against the online KEGG and HMDB databases as well as an in-house standard MS/MS spectral library. A metabolite was annotated if the mass difference between the observed and database values was less than 10 ppm. The MS/MS identification parameters were as follows: MS1 mass tolerance 0.01 Da, MS2 mass tolerance 0.05 Da, and identification score cutoff 75%. Databases used included in-house, Massbank, HMDB, and Lipidblast.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse-phaseLiquid Chromatography MS - positive - reverse-phase<p>Separation was performed on a Waters ACQUITY UPLC system equipped with an ACQUITY UPLC T3 column (100 mm × 2.1 mm, 1.8 μm, Waters, UK). The column oven was maintained at 40°C, and the flow rate was 0.3 mL/min. Mobile phase A consisted of water with 5 mmol/L ammonium acetate and 5 mmol/L acetic acid, and mobile phase B was acetonitrile. The gradient elution program was as follows: 0–0.8 min, 2% B; 0.8–2.8 min, 2%–70% B; 2.8–5.6 min, 70%–90% B; 5.6–6.4 min, 90%–100% B; 6.4–8.0 min, 100% B; 8.0–8.1 min, 100%–2% B; 8.1–10 min, 2% B. The injection volume was 4 μL.</p>Medicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis.Jiangxi University of Chinese Medicinekaimeng huangGastric cancer cell line AGS/HGC-27mass spectrometry assay<p>To the cell pellet, 1000 μL of pre-chilled methanol/acetonitrile/water (MeOH/ACN/H2O, 2:2:1, v/v/v) was added. The mixture was vortexed for 30 s and sonicated at 4°C for 10 min. This was followed by flash-freezing in liquid nitrogen for 1 min and sonication at 4°C for 10 min, repeated three times. The samples were then incubated at -20°C for 1 h to precipitate proteins. After centrifugation at 13,000 rpm and 4°C for 15 min, 720 μL of supernatant was collected and vacuum-dried at 4°C. The dried extract was reconstituted in 100 μL of acetonitrile/water (ACN:H2O, 1:1, v/v), vortexed for 30 s, and sonicated at 4°C for 10 min. Following centrifugation at 13,000 rpm and 4°C for 15 min, the supernatant was transferred for UPLC-HRMS analysis. Quality control (QC) samples were prepared by pooling equal aliquots from each sample, and blank controls were also prepared for quality assurance.</p>Homo sapienshttps://www.ebi.ac.uk/metabolights/MTBLS15900kaimeng huang. Jiangxi University of Chinese Medicine. kaimeng_huang@163.com.Fangfang Tou. Jiangxi Provincial People's Hospital. tou_fangfang@163.com.<p>Raw LC-MS data files were converted to mzXML format using MSConvert software from Proteowizard.</p>Groupkaimeng_huang@163.com<p>Logarithmic-phase human gastric cancer cell lines AGS and HGC-27, as well as normal gastric mucosal epithelial cells GES-1, were collected. Cells were cultured in RPMI-1640 or DMEM medium supplemented with 10% fetal bovine serum and 1% penicillin-streptomycin at 37°C in a 5% CO2 incubator. After treatment with Medicarpin (Med) (Treated group) or an equal volume of vehicle solvent (Control group), the medium was discarded, cells were washed with PBS, and cell pellets were collected and stored at -80°C until analysis. A total of 12 samples were analyzed (6 in the Control group and 6 in the Treated group).</p>MetabolomicsMetabolomicsuntargeted analysisMevalonate pathwayMedicarpinHomo sapiensCultured cellsWaters ACQUITY UPLC systemGastric cancer cell line AGS/HGC-27Cholesterol synthesisMetabolic reprogrammingGastric cancerQ ExactiveMetabolomicsuntargeted analysisMevalonate pathwayMedicarpinHomo sapiensCultured cellsWaters ACQUITY UPLC systemGastric cancer cell line AGS/HGC-27Cholesterol synthesisMetabolic reprogrammingGastric cancerQ Exactive<p>A Q-Exactive high-resolution mass spectrometer (Thermo Fisher Scientific, Bremen, Germany) equipped with an electrospray ionization (ESI) source was used, with data acquired in both positive and negative ion modes. For full-scan MS, the scan range was 70–1050 m/z at a resolution of 70,000 (@ m/z 200), with an AGC target of 3e6 and a maximum injection time of 100 ms. For MS/MS, data-dependent acquisition (DDA) was employed at a resolution of 17,500 (@ m/z 200) with a maximum injection time of 50 ms. A QC sample was injected after every 10 samples to calibrate the systematic error of the entire batch based on mass differences among QC samples.</p>2-GalloylglucoseLysoPC(20:3(8Z,11Z,14Z)/0:0)Panaxacoldocosa-4,7,10,13,16-pentaenoateProstaglandin G22,5-Di-tert-butylhydroquinoneRiboflavinLinalyl hexanoatePyrocatecholEicosapentaenoic ethyl esterDhv-PGE2Methyl linolenate13,14-dihydro-prostaglandin F2alphaLinalyl isobutyrateFolic acidDeoxyinosine4-Cresol sulfate8-hydroxyhexadecanoyl-CoA1-(11Z-eicosenoyl)-glycero-3-phosphateNonane-4,6-dione1-Heneicosanoyl-glycero-3-phosphoserineGinkgoic acid2-Ketocaproic acidPrecursor ZKetoleucine3-Methylbutyl 3-oxobutanoateent-17-Acetoxy-16b-kauran-19-alN-arachidonoyl-methionineLysoPC(0:0/18:2(9Z,12Z))Caplamin6-hydroxy-FADAuxin bIcosanoic acid2S-Hydroxytetradecanoic acid2',6'-Dihydroxy-4'-methoxydihydrochalcone1-18:0-2-18:1-phosphatidylserineDimethylcarbamic acidTyrosyl-GlutamateIsophthalatericinoleoyl-CoACapric acidPhenolOctadecanedioic acidNicotinamide adenine dinucleotide phosphate (NADP)N-Acetylaspartic acidMalyl-CoAMethyl-alpha-aminoisobutyric acidN-Arachidonoyl CysteineS-Succinylglutathione1-palmitoleoyl-sn-glycero-3-phosphocholineNordihydrocapsiateCetirizine (Drug)4-Hydroxybenzaldehyde2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, phenyl esterN-arachidonoyl-valineDeoxythymidine 5'-diphosphate (dTDP)Glyceryl 5-hydroxydecanoateAdenosine 5'-triphosphate (ATP)Glycinebutyl benzoate5'-S-Methyl-5'-thioinosineReduced nicotinamide adenine dinucleotide (NADH)Cetoleic acidGuanosine 5'-triphosphate (GTP)CystathionineGlutaric acidPC(O-16:0/20:5(5Z,8Z,11Z,14Z,17Z))GlutathioneGlycerol 1-dodecanoate 2-tetradecanoate 3-octanoateAdenylsuccinic acidN-Lauroyl MethionineGlutamylisoleucine2-Tetracosenoic acidProstaglandin D2 (PGD2)[7]-ParadolDeoxyguanosine triphosphate (dGTP)2-Methylglutaric acidgamma-GlutamylphenylalanineEthyl (E,Z)-decadienoateGentisaldehyde1-acyl-sn-glycero-3-phosphoglycerol (n-C18:0)4-Acetamidobenzoic acid16-Oxopalmitate2-Hydroxypalmitic acid3-hydroxynonanoyl carnitine1-16:0-2-18:2-phosphatidylinositolN-Acetylneuraminic acidPantothenic acid10-Undecenoic acidPE(16:0/20:4(5Z,8Z,11Z,14Z))Allolithocholic acid1,2-Bis(4-hydroxy-3-methoxyphenyl)ethyleneN-Eicosapentaenoyl GlycineGuanosineIsovaleric acidRibothymidine3-Hydroxydecanoic acidm-Methylbenzoate3-hydroxynonanoate2,6-Dimethoxy-4-(1-propenyl)phenolErucic acidguanosine 2'-monophosphateTyrosyl-AspartateAlprostadil20a,20b-Dihomo-9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acidApo-8'-carotenoic AcidDihydroxyoctadecenoic acid3-Oxocholic acid2-Methoxy-5Z-hexadecenoic acid2-Hydroxydecanoic acidSuccinyladenosinePhenyllactatePhe-GlyN-Eicosapentaenoyl Asparagine2-Amino-5-[[1-[carboxymethyl(2-hydroxypropanoyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acidMono(2-ethylhexyl) phthalateHexadecanedioic acidtrans-2-Octenoic acid2-Aminoisobutyric acidPI(18:1(9Z)/20:4(5Z,8Z,11Z,14Z))2,4-Di-tert-butylphenolN-Stearoyl ThreonineDeoxycholyl-dopaMono(1-ethylhexyl) phthalateN-Docosahexaenoyl GABALysoPS(16:0/0:0)Docosapentaenoic acid (DPA)1-(9Z-hexadecenoyl)-glycero-3-phosphate1-18:0-2-18:1-phosphatidylcholineUridine1-(9Z-Nonadecenoyl)-glycero-3-phosphoethanolamine1-18:2-2-18:2-phosphatidylethanolamineLysoPC(20:3(5Z,8Z,11Z)/0:0)Chenodeoxycholic acidGlutamic acid diethyl ester1-Octadecanoyl-sn-glycero-3-phosphoethanolamine3-Hydroxybenzoic acid4-HydroxyphenylacetaldehydeCysteineReduced nicotinamide adenine dinucleotide phosphate (NADPH)Cervonoyl ethanolamidegamma-Glu-IleHydroxyprogesterone caproate12,13-Epoxy-11-hydroxy-9,15-octadecadienoic acid7-hydroxyhexadecanoyl-CoASerineSterculic acid3-Hydroxymyristic acid1-18:0-2-18:2-phosphatidylethanolamineProline4-(Methylamino)butanoic acidDihydroxyoctadecanoic acidProstaglandin A24-Glucosyl gallate16-B1-phytoprostaneNelarabinePhenylsulfateIsocitric acid12-Oxo-10,11-dihydrophyto-15-enoateButyl levulinate1-oleoyl-2-palmitoyl-phosphatidylglycerolN-LauroylglycineS-PyruvylglutathioneFructose 2-phosphateAdenosineLauroyl-CoAPinostrobin chalconeAllopurinolProstaglandin F2alpha (PGF2a)Monooctyl phthalateMethyl [6]-paradolent-16b,19-Kauranediol 19-acetateTetracosahexaenoic acid, n-3LysoPC(0:0/20:4(5Z,8Z,11Z,14Z))2-Hydroxycinnamic acid12,13-DiHOME6,8-TetracosanedionePIP2(16:0/16:1(9Z))Myristoyl-CoA18-Nitrooctadec-9-enoic acidFumaric acidTryptophyl-ProlineN-Lactoylvaline2,3-Dinor-8-iso prostaglandin F2alphaMethyleugenolAdenosine 3',5'-diphosphate (PAP)Glucose-6-phosphate lactate3-Decenoic acid4,4'-Diaponeurosporen-4-alBenzoic acid6-Oxotetradecanoic acid7-[3-Hydroxy-2-[3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-2-enoic acidPhe-ProTrp-GluDocosahexaenoic acid ethyl ester11-Hydroxy-9-tridecenoic acid3,4-Dimethyl-5-pentyl-2-furanundecanoic acidTetradecanedioic acidTraumatic acidDocosahexaenoic acidLPE(16:0)gamma-GlutamyltyrosineTetracosahexaenic acidGlyzarin3alpha,7beta-dihydroxy-5beta-cholest-24-en-26-oic Acid3'-O-MethylguanosineProstalenePC(P-16:0/20:4(5Z,8Z,11Z,14Z))17beta-Hydroxy-17-methylandrost-4-ene-3,11-dioneEpoxydocosapentaenoic acidADPribose 2'-phosphategamma-GlutamylleucineFolinic acidLysoPE(20:4(5Z,8Z,11Z,14Z)/0:0)ADP-ribose 2'-phosphateNonadeca-2,4-dienoic acidHexacosahexaenoic acid9,12,13-TriHOMETerephthalic acid3-hydroxyundecanoyl carnitineIsodeoxycholic acid7,9-TetracosanedioneN-Undecanoylglycine10,12-TetracosanedioneFAHFA(18:1(9Z)/9-O-18:0)10-Deoxygeniposidic acidValeric acid1-acyl-sn-glycero-3-phosphoglycerol (n-C16:0)Lysinetrans-Cinnamic acidButyllactatephosphatidylglycerol (1-palmitoyl, 2-cis-vaccenoyl)Sweroside6-MethylgingediolGeranylgeranylcysteineOctadecatetraenoyl-CoAPI(16:0/20:4(5Z,8Z,11Z,14Z))Ethyl 3-phenylpropanoate3-Methylbutyl 2-furanbutanoateSuberic acidPIP2(16:1(9Z)/16:0)Nicotinamide adenine dinucleotide (NAD)DihydrocapsiatePinocembrin chalconeN-oleoyl-glutamate8-Hydroxyoctanoic acidNitro-oleic acidPC(18:1(9Z)/20:4(5Z,8Z,11Z,14Z))tetracosatetraenoateLPS(18:1)1-Hydroxy-1-phenyl-3-octadecanone5'-Methylthioadenosine4-NitrophenolHydroxyacetonePE(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-sn-glycerolPalmitoylglycerone phosphate3-NitrophenolN-Acetylphenylalanine1,3-Butyleneglycol dimethacrylateChenodeoxycholyl-dopaCytidine 5'-monophosphate (CMP)Octadecatrienoic acidCoenzyme A (CoA)1,2-didecanoyl-sn-glycero-3-phosphocholinecis-4-Octenedioic acid2-Hydroxyoctanoic acidProstaglandin E2 (PGE2)XanthosineAspartateGuanosine 5'-diphosphate (GDP)2,4-Dihydroxy-6-(8-pentadecenyl)benzoic acid3-Methyl-2-oxovaleric acidDesaminotyrosineN-palmitoyl-phenylalanineAdenosine 2',3'-cyclic phosphatePentadec-2-enoylcarnitineMannose 1-phosphateCitric acid1-O-GalloylfructoseLipoyl-GMP5-Aminopentanoic acidValine1-18:2-2-18:2-phosphatidylinositol7',8'-Dihydro-8'-hydroxycitraniaxanthinpGp4-Hydroxyglutamate semialdehyde6-O-galloylglucosealpha-Licanic acid1-O-Myristoyl-2-acetyl-glycerolTetracosapentaenoic acid (24:5n-6)Cytidine 5'-diphosphate (CDP)3,4-Dimethyl-5-propyl-2-furantridecanoic acidMethyl-[10]-shogaolHydroxyisocaproic acidGlutathione disulfideFAHFA(18:1(9Z)/10-O-18:0)Succinyl-CoA3-Oxovalproic acidGlutamylvalineLinalyl butyratedADPTetracosenoic acidDeoxycholyltyrosineLiothyronine9-Oxo-10(E),12(E)-octadecadienoic acidOctadecanoic acid9beta,11beta-Epoxy-17beta-hydroxy-17-methylandrost-4-en-3-one4-Octylphenol6,8-DocosanedioneLithocholate 3-O-glucuronideTyrosyl-Lysine10-OPDAGlucose 6-phosphateIndole-3-carboxaldehyde15-Deoxyprostaglandin J28HPETE2,3-Dimethylsuccinic acid9-Oxononanoic acid3-Hydroxy-1-phenyl-1-octadecanone1-Phenyl-1,3-octadecanedioneUndec-6-enoylcarnitine2,4-dihydroxybutanoateN-palmitoyl-threonineUrethane2'-Deoxyadenosine 5'-monophosphate (dAMP)Asp-Phe2-Methylpropyl benzoateGlutamate2-Hydroxy-3-methylpentanoic acidProstanoic acidHydroquinoneToluate8HETrEPE(P-16:0/20:4(5Z,8Z,11Z,14Z))2',4',6'-Trihydroxy-3'-formyldihydrochalconeDeoxythymidine 5'-phosphate (dTMP)12,15-Epoxy-13,14-dimethyleicosa-10,12,14-trienoic acidalpha-C-MannosyltryptophanMonobutyl phthalate16-hydroxypalmitoyl-CoAThreonylcarbamoyladenylate5-[4-Hydroxy-2-[3-hydroxyoct-1-enyl]oxan-3-yl]pent-3-enoic acid2-Aminoadipic acid2',4',6'-Trihydroxydihydrochalcone 4'-glucosidePI(16:0/18:0)1-Palmitoyl-2-(5-keto-6-octenedioyl)-sn-glycero-3-phosphocholineProstaglandin I211'-Carboxy-gamma-tocotrienol2-{[Hexadec-9-enoyl]oxy}-3-hydroxypropyl 2-(trimethylazaniumyl)ethyl phosphateChalconosakuranetintetradecenoyl-CoAGibberellin A12 aldehydeLanceolatin CDodecanoic acid2-Oxooctadecanoic acid3,4-Dimethyl-5-propyl-2-furannonanoic acidLysoPE(P-18:0/0:0)5-Nitroxystearic acidEthyl aconitateAnnoglabasin FO-Acetyl-serine12-Oxophyto-10,15-dienoate1-linoleoyl-sn-glycero-3-phospho-(1'-sn-glycerol)5beta-Cholanic acidDeoxythymidine triphosphate (dTTP)Tryptophyl-CysteinePI(16:0/18:1)Methyl linoleateLimaprost13,16,19-Docosatrienoic acidFAHFA(18:1(9Z)/8-O-18:0)N-Myristoyl Cysteine1-18:1-2-18:1-phosphatidylethanolamine2-Hydroxyglutaric acidPelargonic acid13(S)-HODE3-AminopentanedioateMono-(2-ethyl-5-hydroxyhexyl) phthalateTetracosapentenoic acid11-Hydroperoxyoctadeca-9,12-dienoic acidMethyl ethyl ketoneSarcosine13-Oxo-9,11-tridecadienoic acidMethylmalonyl-CoAS-(2-Hydroxy-3-buten-1-yl)glutathione16-Hydroxypalmitic acidTaurineLicochalcone B2-methylcitrateGlutamyltyrosinePhosphatidylinositols,soya2-Methylvaleric acidMannose 6-phosphate3-hydroxyhexadecanoateLithocholic acidxi-7-Hydroxyhexadecanedioic acidTridecanoylglycine10-Hydroxy-3-oxooctadecatrienoic acidGlycerol 1,3-didodecanoate 2-decanoatePE(P-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Docosahexaenoicacid(DHA)Oleoyl-CoA5-Hydroxyvalproic acid5-HydroxytryptophanTridecanedioic acidFurfuryl octanoatebeta-AlanineF4-Neuroprostane (4-series)Geranyl acetoacetateN-Formylmethionine3-Hydroxyhexadecanoyl-CoAMyristoleic acidPsicofuranine17beta-(Hydroxymethyl)androst-4-en-3-one acetateDocosatrienoic acidMethionine1,2-dioctanoylglycerolGuanosine 3'-phosphateTetranorprostanedioic acid9-Oxooctadecanoic acidAsebogenin4-Methylbenzenesulfonic acidGlycerol 1-(5-hydroxydodecanoate)N-Oleoyl Isoleucine1,2-Epoxy-1,2,7,7',8,8',11,12-octahydro-psi,psi-caroteneN-palmitoyl-leucine4-HydroxyprolineHydrangeic acid5-oxo-prolyl-valine3-Glucogallic acidUndecanoic acidFAHFA(18:1(9Z)/11-O-18:0)Ethyl icosapentatetetradec-4-enoyl-CoAPenicillin GOryzarolOleoylcarnitine (C18:1)Retinol acetateProstaglandin H2 (PGH2)2-Aminobutyric acidGlycerylmonooleateLeukotriene C41-Heptadecanoylglycerophosphoethanolamine6-Paradol4'-Apo-beta,psi-caroten-4'-alall-trans-8'-Apo-beta-carotenal15-Docosenoic acidProstaglandin F1alphaPhenylalanine4-Oxononanal1-Linoleoylglycerophosphocholine [M]DeoxycholylphenylalaninePhenylacetylglycineFADH2Prolylhydroxyprolinetetracosa-9,12,15,18,21-pentenoateGuanosine 5'-monophosphate (GMP)3-Phenylpropanoic acid2-(Butanoylamino)-5-[[2-(carboxymethylamino)-2-oxo-1-(sulfanylmethyl)ethyl]amino]-5-oxo-pentanoic acidDecadienedioic acid[6]-Gingerol7-Hydroxydodecanoate2,4,6-TrimethoxybenzophenoneUracil1-arachidonoyl-sn-glycero-3-phosphocholinepinolenateIndolelactic acidN-(3-Oxooctanoyl)homoserine lactone2-Dehydro-glucono-1,5-lactoneNorleucine2,4-NonanedioneCreatineN-palmitoyl-glutamate5-Aminolevulinic acid2-MethylserineCaprylic acidBoc-cysteine1-18:0-2-18:2-phosphatidylserine8-Oxo-dGDPIsosteviolCiprosteneTyrosine1-Oleoyl-sn-glycerol 3-phosphate3-SuccinoylpyridineN-Eicosapentaenoyl TyrosineGrevillol9-Hydroxyoctadecanoic acid3-Methoxy-2-(4-methylbenzoyl)-4H-1-benzopyran-4-oneN2,N2-Dimethylguanosine3-Ureidopropionic acidEthyl acetate1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide3-Amino-3-(4-hydroxyphenyl)propanoic acid2HOTN-methyl-valineN-(4-aminobenzoyl)-glutamateN-palmitoyl-lysineLysoPI(0:0/18:0)3-Hydroxylauric acidOxalic acid3-Methyl-5-pentyl-2-furanpropanoic acidHypoxanthine2,4,6,8,10,12-Docosahexaenoic acid, ethyl esterAdipic acidProlyl-TryptophanHomoserine2'-Deoxyguanosine 5'-diphosphate (dGDP)5Z,8Z,11Z-Eicosatrienoic acidHippuric aciddocosapenta-2,4,6,8,10-enoatePivagabineUridine 5'-monophosphate (UMP)3-hydroxybenzaldehyde1-PalmitoyllysophosphatidateLPE(18:1(9Z)/0:0)Dihydroxyoctadeca-9,12,15-trienoic acidbeta-Guanidinopropionic acidN-lactoyl-TyrosineF4-Neuroprostane (7-series)4-Phenylbutanoic acidN-Stearoyl GABAImazamethabenzN-Myristoyl Methionine16-Hydroxy-9,12,14-octadecatrienoic acid3-Hydroxy-palmitic acid methyl ester1,2-Dioleoyl-sn-glycero-3-phosphoglycerolUDP-N-acetylglucosamineMethyl palmitateGly-Ala2-Hydroxybutyric acidApigenin 7-glucuronidethreo-3-MethylaspartateIsoleucine2-Methyl-3-hydroxybutyric acidCrepenynate5-Hydroxypentanoate1-oleoyl-2-linoleoyl-phosphatidylcholineArachidonic acid (AA)3beta,7alpha-Dihydroxy-5-cholestenoatePhenyl glucuronideAdenineAcetoinAcetyl-CoAhematoxylene10-Oxo-8-decenoic acid4,4'-Diaponeurosporenic acid2,2'-Iminodiacetic acidPovpc3'-N-Acetyl-4'-O-(10,12-octadecadienoyl)fusarochromanoneN-Palmitoyl Cysteine5Z,13Z-Docosadienoic acidPC(18:0/20:4)InosineCytidine 5'-diphosphocholine (CDP-choline)1-Hydroxy-2,12,15-heneicosatrien-4-onexi-5-Hydroxydodecanoic acidLumichromeN,N-DiethylglycineDimethylglycineLysoPE(20:0/0:0)Asp-LeuN-Hydroxy-tryptophanGlutamine2-Pyrrolidinone18-Hydroxyeicosapentaenoic acid9,10,18-Trihydroxystearate5,10-methylene-THFPhenylacetic acid12,15-Epoxy-13,14-dimethyleicosa-12,14,16-trienoic acidCaproic acidPC(15:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))Octadec-11-en-9-ynoic acidFAHFA(18:1(9Z)/12-O-18:0)3,4-Dimethyl-5-pentyl-2-furanheptanoic acidAdenosine 5'-diphosphate (ADP)2-Ethylicosa-2,4,6,8,10-pentaenoic acidMyristoylglycineNaringin chalconeUridine 5'-triphosphate (UTP)N-AcetylmethionineAla-Gly2-hydroxy-palmitoyl-CoAHistidineAla-Glu3,4-Methylenesebacic acid2-O-Glutaroyl-1-O-palmitoyl-sn-glycero-3-phosphocholineEthylmalonic acidN-oleoyl-leucine10-nitrooctadecenoic AcidAcetylleucineMono-benzyl phthalate9-nitrooctadecenoic AcidPropionic acid4-Hydroxybenzoic acid15-HETE9-Octadecenoic acid , (2-hydroxy-2-oxido-1,2-oxaphospholan-4-yl)methyl ester2-acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)12-Hydroxydodecanoic acidValproic acid1-Methyl-2-oxopropyl butyrateSebacic acid5,6-DHET15-OxoETEapo-8'-lycopenalCorchorifatty acid AMaackiainCysteinylglycineNicotinamidePalmitoylcarnitine (C16:0)Corchorifatty acid DN-arachidonoyl-threonineN-Docosahexaenoyl CysteineTheophylline13(S)-HpOTrEtetracosa-6,9,12,15,18,21-hexaenoate1-stearoyl-sn-glycero-3-phosphoinositolN-LactoylleucineFlavin mononucleotide (FMN)2,3-Dinor-8-iso prostaglandin F1alpha7-Ketodeoxycholic acid3-Methylglutaric acid1-(11Z,14Z-eicosadienoyl)-glycero-3-phosphatePhthalateAcetyl-maltose1-myristoyl-sn-glycero-3-phosphocholine11-Tetradecenoyl-CoA7,9-DocosanedioneAnnosquamosin ADiisobutyl phthalatemyo-Inositol10,16-Dihydroxyhexadecanoic acidThyroxineCosahexaenoic acidMethyl n-acetylanthranilatePyroglutamic acid5-Methyldihydrofolic acidKynurenine3-Hydroxyoctanoic acidLinoleoyl-CoAUridine 5'-diphosphate (UDP)2-Nitrophenol6-Hydroxypentadecanedioic acidHydroxyphenyllactic acidAdenosine 3',5'-cyclic phosphate (cAMP)Prostaglandin B2 (PGB2)5-Hydroxy-1-(3-hydroxy-4-methoxyphenyl)decan-3-oneN-LactoylphenylalanineSalicylic acidAlanine2-MethylguanosineLevulinic acidDodecanedioic acidTryptophanXanthineFructose 6-phosphateDeoxyguanosineoctadeca-8,10,12-trienoate4'-Methoxybenzophenone-2-carboxylic acid1-StearoylglycerophosphoserineAsparagine10-Formyltetrahydropteroyldiglutamateisoleucyl-glutamate2-Hydroxyisobutyric acid5-OxoETEsn-glycero-3-phospho-N-(arachidonoyl)ethanolamineN-DecanoylglycineLactate(4Z,9a)-9-Angeloyloxy-4,10(14)-oplopadien-3-oneHeptyl p-hydroxybenzoateDibutyl phthalate6-Keto-prostaglandin F1alpha2-Hydroxyhexanoic acid5,7-TetracosanedioneIsocaproic acid17-methyloctadecanoylcarnitinePantetheineent-15-Oxo-16-kauren-19-oic acid2-acyl-sn-glycero-3-phosphoglycerol (n-C18:0)leucyl-glutamateMethylmalonic acidAdenosine monophosphate (AMP)11-MethoxyyangoninMaleic acidMalic acidFlavin adenine dinucleotide (FAD)13,14-dihydro-prostaglandin E1GlutamylleucineDihomo-gamma-linolenateGluconic acid1-CarboxyethyltyrosineGarcimangosone D3-oxo-myristate3-Amino-4-methylpentanoic acidIndole-3-acetaldehydeIMPUndecanedioic acidS-AdenosylhomocysteineO-(17-Carboxyheptadecanoyl)carnitineCysteinyl-Tryptophan3-Hydorxy-3-methylglutaric acid1-icosanoyl-sn-glycerol 3-phosphate2-Hydroxy-2-methylbutyric acidDocosadienoic acidPyruvaldehydeHeptadecanoyl carnitine12-Hydroxystearic acidN-Palmitoyl IsoleucineDiglycineButyl 3-hydroxy-2-methylidenebutanoatePC(16:1(9Z)/20:0)Butanoic acidIsolithocholic acidChenodeoxycholyltyrosineLeucine18-Hydroxyoleoyl-CoATaurodeoxycholic acidKelatorphanDihydrobisanhydrobacterioruberinHydnocarpic acid4-Aminobutyric acid (GABA)Azelaic acidN-arachidonoyl-glutamateCholyltyrosine3'-N-Acetyl-4'-O-(9-octadecenoyl)fusarochromanone1-heptadecanoyl-sn-glycero-3-phosphocholineBaicalinUridine 5'-diphosphoglucuronic acid (UDP-glucuronate)4-O-Methylpinosylvic acidglycine methyl ester3,4,5-Trihydroxy-6-(5-methyl-2-propan-2-ylphenoxy)oxane-2-carboxylic acid2',4',6'-Trihydroxydihydrochalcone 2'-glucosidemalonyl-CoA methyl ester16,16-Dimethylprostaglandin E2Phenylalanine glutamateDeoxycholic acidPE(P-18:0/20:4(5Z,8Z,11Z,14Z))S-LactoylglutathioneHelichysetin2-Methylpropyl 3-hydroxy-2-methylidenebutanoateLysoPS(18:2(9Z,12Z)/0:0)IsatinPE(P-18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))trans-Tetradec-2-enoyl-CoA9-Hydroxyoctadecenoyl-CoA2-MethylpropanoateChenodeoxycholylphenylalanine2'-Deoxyguanosine 5'-monophosphate (dGMP)3-hydroxy-octadecenoyl-CoA1,7-DimethylxanthinefalseMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesisBackground: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic mechanisms remain unclear. Methods: The effects of Med on cell viability, proliferation, colony formation, and migration were evaluated in AGS and HGC-27 GC cells. Its antitumor efficacy and preliminary tolerability were assessed in nude-mouse xenograft models. Untargeted metabolomics and quantitative proteomics were integrated to identify Med-associated metabolic alterations and targets. Western blotting, cholesterol measurement, Filipin staining, and exogenous cholesterol rescue assays were performed to validate the mechanism. Results: Med significantly inhibited the viability, proliferation, clonogenicity, and migration of AGS and HGC-27 cells in a concentration- and time-dependent manner, while showing minimal cytotoxicity in normal gastric mucosal GES-1 cells. In xenograft models, Med reduced tumor volume and weight without body-weight loss or histopathological injury to major organs. Multi-omics analyses revealed extensive metabolic remodeling, with marked suppression of lipid, steroid, and primary bile acid biosynthesis. Proteomic analysis and Western blotting showed that Med downregulated the key mevalonate pathway enzymes MVK, HMGCS1, and LSS, thereby reducing intracellular cholesterol levels. Exogenous cholesterol supplementation substantially reversed Med-induced inhibition of GC cell viability, proliferation, and colony formation. Conclusion: Med suppresses GC progression by downregulating MVK, HMGCS1, and LSS, thereby inhibiting mevalonate pathway-mediated cholesterol biosynthesis. These findings support Med as a promising natural candidate for targeting lipid metabolic reprogramming in 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