Venous blood samples from the participants were collected in EDTA tubes after an overnight fast and plasma was separated and stored in -80 °C until shipment to the service provider for measurement.
"],"omics_type":["Metabolomics"],"study_design":["ultra-performance liquid chromatography-mass spectrometry","metabolon","tandem mass spectrometry","untargeted metabolites","biomarker","human gut microbiome"],"curator_keywords":["ultra-performance liquid chromatography-mass spectrometry","metabolon","tandem mass spectrometry","untargeted metabolites","biomarker","human gut microbiome"],"mass_spectrometry_protocol":["A Thermo Scientific Q-Exactive high resolution/accurate mass spectrometer interfaced with a heated electrospray ionization (HESI-II) source and Orbitrap mass analyzer operated at 35,000 mass resolution was used. The MS analysis alternates between MS and data-dependent MSn scans using dynamic exclusion."],"metabolite_name":["hydroxycotinine","2'-O-methylcytidine","salicylate","4-hydroxyphenylpyruvate","N-acetylthreonine","glycerophosphoethanolamine","1-palmitoyl-GPI (16:0)","5alpha-androstan-3beta,17alpha-diol disulfate","1-methylxanthine","ribonate","2-hydroxyglutarate","N-palmitoylglycine","losartan","glutamate","lanthionine","cytidine","ibuprofen","N-acetyltyrosine","cortisol","1-oleoyl-2-docosahexaenoyl-GPC (18:1/22:6)*","pioglitazone","2-oxoarginine*","N-formylphenylalanine","1-oleoyl-GPI (18:1)","guaiacol sulfate","benzoate","N-oleoyltaurine","hydantoin-5-propionate","3beta,7alpha-dihydroxy-5-cholestenoate","sulfate*","diazepam","alpha-ketoglutarate","tauroursodeoxycholate","3-hydroxydecanoate","tryptophan betaine","asparagine","beta-citrylglutamate","N2,N2-dimethylguanosine","lyxonate","tyramine O-sulfate","ornithine","creatinine","venlafaxine","desmethylnaproxen","4-hydroxyhippurate","2,6-dihydroxybenzoic acid","5-hydroxyhexanoate","2-acetamidophenol sulfate","allopurinol","6-hydroxyindole sulfate","norfluoxetine","4-hydroxycoumarin","gamma-glutamyl-2-aminobutyrate","2-hydroxypalmitate","N1-methyladenosine","glucose","citrate","lamotrigine","phenylpyruvate","S-methylcysteine sulfoxide","metformin","taurocholate","prolylglycine","21-hydroxypregnenolone disulfate","sphingomyelin (d18:2/18:1)*","N6-succinyladenosine","urate","taurochenodeoxycholate","glycodeoxycholate","pro-hydroxy-pro","guanidinoacetate","1-(1-enyl-palmitoyl)-2-linoleoyl-GPE (P-16:0/18:2)*","3-phosphoglycerate","N-formylmethionine","N6-carboxymethyllysine","xanthosine","lactate","corticosterone","3-hydroxyoleoylcarnitine","cysteine","2-hydroxysebacate","pipecolate","N-acetyl sulfapyridine","2-hydroxy-4-(methylthio)butanoic acid","sphingosine","3-methyladipate","cetirizine","arginine","cystathionine","glipizide","ribitol","etiocholanolone glucuronide","didesmethylcitalopram*","picolinoylglycine","vanillactate","leucine","clomipramine","N-acetyl-isoputreanine","ethyl beta-glucopyranoside","taurolithocholate 3-sulfate","S-methylcysteine","hydroquinone sulfate","picolinate","gamma-glutamyltyrosine","oxypurinol","sitagliptin","N-acetylmethionine","methionine","metronidazole","1,7-dimethylurate","malonylcarnitine","4-vinylphenol sulfate","4-ethylphenylsulfate","2-ketocaprylate","thyroxine","solifenacin","hydroxyasparagine**","1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4)*","2-methylserine","maleate","1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1)*","caffeine","gamma-glutamylisoleucine*","N4-acetylcytidine","thymol sulfate","3-ureidopropionate","imidazole propionate","4-cholesten-3-one","arabitol/xylitol","mannitol/sorbitol","4-hydroxy-2-oxoglutaric acid","2-hydroxycarbamazepine","5-hydroxylysine","quinate","12,13-DiHOME","1-palmitoyl-GPE (16:0)","androsterone glucuronide","3-hydroxyhexanoate","ritalinic acid","N-acetylleucine","metoprolol","carnitine","betaine","N-desmethyl tramadol","C-glycosyltryptophan","gluconate","eugenol sulfate","inosine","sarcosine","indole-3-carboxylate","piperine","N-alpha-acetylornithine","(R)-3-hydroxybutyrylcarnitine","3-methoxytyrosine","hippurate","hypoxanthine","3-methoxytyramine sulfate","glycine","phenylacetylglutamine","1-methylhistidine","gamma-carboxyglutamate","1-hydroxy-2-naphthalenecarboxylate","pregnenolone sulfate","sertraline","glycolithocholate","theophylline","4-hydroxyphenylacetate","glycerol 3-phosphate","cystine","gamma-glutamylalanine","1,3,7-trimethylurate","methylsuccinate","1,3-dimethylurate","4-hydroxyphenylacetylglutamine","sulfamethoxazole","alpha-hydroxymetoprolol","taurohyocholate*","2-stearoyl-GPE (18:0)*","3-hydroxycotinine glucuronide","1-palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6)*","retinal","3-(cystein-S-yl)acetaminophen*","morphine-3-glucuronide","N6,N6-dimethyllysine","N-acetyl-3-methylhistidine*","3-hydroxyhippurate","trans-4-hydroxyproline","2,3-dihydroxypyridine","desmethylnaproxen sulfate","2-methoxyacetaminophen sulfate*","N-desalkylquetiapine*","carboxyethyl-GABA","1-palmitoyl-2-stearoyl-GPC (16:0/18:0)","N-(2-furoyl)glycine","N,N-dimethylalanine","3-hydroxydecanoylcarnitine","valsartan","16a-hydroxy DHEA 3-sulfate","morphine-6-glucuronide","pantothenate","4-ethyl-2-methoxyphenol sulfate","tryptophan","isovalerylglycine","2-hydroxybutyrate/2-hydroxyisobutyrate","citramalate","3-hydroxyisobutyrate","1-(1-enyl-stearoyl)-2-linoleoyl-GPE (P-18:0/18:2)*","trimethylamine N-oxide","arabonate/xylonate","1-(1-enyl-stearoyl)-GPE (P-18:0)*","6-oxopiperidine-2-carboxylate","ibuprofen acyl glucuronide","hydroxyurea","orotidine","trizma acetate","linoleoyl ethanolamide","histidine","galactonate","cortisone","serine","N-acetylglutamine","N-acetylputrescine","doxylamine","N-stearoylserine*","5alpha-pregnan-3beta,20alpha-diol disulfate","cysteinylglycine","nicotinamide","rivaroxaban","2-aminoadipate","3-hydroxyadipate","propionylglycine","isobutyrylglycine","norcotinine","bendroflumethiazide","propyl 4-hydroxybenzoate sulfate","1-methylurate","arachidonoylcholine","3-methyl-2-oxovalerate","1-methyl-4-imidazoleacetate","N-acetylcarnosine","montelukast","beta-hydroxyisovalerate","desmethylcitalopram*","sphingosine 1-phosphate","aspartate","N-acetylglucosamine/N-acetylgalactosamine","spermidine","temazepam","beta-sitosterol","alliin","verapamil","5,6-dihydrothymine","taurine","taurocholenate sulfate*","acesulfame","4-hydroxychlorothalonil","gamma-glutamylleucine","warfarin","N-palmitoylserine","ascorbic acid 3-sulfate*","3-methylxanthine","proline","beta-cryptoxanthin","valproate","4-acetamidophenol","malate","hypotaurine","gamma-glutamylglutamine","4-guanidinobutanoate","palmitoyl sphingomyelin (d18:1/16:0)","campesterol","beta-hydroxyisovaleroylcarnitine","hexanoylglycine","stachydrine","2'-O-methyluridine","2-piperidinone","1-palmitoyl-2-oleoyl-GPC (16:0/18:1)","lidocaine","pantoprazole","uridine","promethazine","hydroxybupropion","atenolol","1-lignoceroyl-GPC (24:0)","N2,N5-diacetylornithine","methyl-4-hydroxybenzoate sulfate","2-methoxyresorcinol sulfate","mannose","tartarate","pseudouridine","glycohyocholate","7-methylguanine","cholic acid glucuronide","threonine","9,10-DiHOME","stearidonate (18:4n3)","thioproline","gamma-glutamylvaline","bilirubin (Z,Z)","oleoyl ethanolamide","1-stearoyl-2-arachidonoyl-GPE (18:0/20:4)","saccharin","4-hydroxy duloxetine glucuronide*","5-acetylamino-6-amino-3-methyluracil","oxazepam","pyridoxate","erythronate*","phosphoethanolamine","3-indoxyl sulfate","kynurenine","guanidinosuccinate","deoxycarnitine","doxycycline","4-acetylphenol sulfate","methyl indole-3-acetate","leucylglycine","serotonin","N-acetylarginine","4-oxo-retinoic acid","8-methoxykynurenate","N-methylhydroxyproline**","furosemide","cholesterol","4-imidazoleacetate","carboxyibuprofen","tamoxifen","1-linolenoyl-GPC (18:3)*","N6-carbamoylthreonyladenosine","ranitidine","2-ethylphenylsulfate","orotate","1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6)*","N6-methyllysine","3-hydroxypyridine sulfate","glucuronate","deoxycholate","salicyluric glucuronide*","methionine sulfoxide","chiro-inositol","isoursodeoxycholate","zolpidem","trimethoprim","creatine","xylose","behenoyl sphingomyelin (d18:1/22:0)*","N4-acetylsulfamethoxazole*","dihydroferulate","1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6)","phenylacetate","oleoylcholine","1-palmitoyl-2-linoleoyl-GPE (16:0/18:2)","1-oleoyl-2-linoleoyl-GPE (18:1/18:2)*","1-palmitoyl-2-linoleoyl-GPC (16:0/18:2)","celecoxib","2-butenoylglycine","gamma-glutamylglutamate","fexofenadine","5-oxoproline","1-linoleoyl-GPE (18:2)*","arabinose","dimethylglycine","morphine","tigloylglycine","valproic acid glucuronide","1-myristoyl-2-palmitoyl-GPC (14:0/16:0)","cytosine","p-cresol glucuronide*","glycocholenate sulfate*","quinolinate","alanine","L-urobilin","2-aminophenol sulfate","3beta-hydroxy-5-cholestenoate","N1-methylinosine","7-hydroxywarfarin","cys-gly, oxidized","1-(1-enyl-palmitoyl)-GPE (P-16:0)*","indolelactate","trans-urocanate","2-naphthol sulfate","1-palmitoyl-GPC (16:0)","3-hydroxy-3-methylglutarate","S-1-pyrroline-5-carboxylate","nicotinamide riboside","3-methylcytidine","N-acetylneuraminate","5,6-dihydrouridine","prednisolone","paroxetine","3-(3-amino-3-carboxypropyl)uridine*","xanthine","1-stearoyl-2-oleoyl-GPC (18:0/18:1)","indolepropionate","4-chlorobenzoic acid","dopamine 3-O-sulfate","phenol sulfate","9-hydroxystearate","o-cresol sulfate","fumarate","1-stearoyl-2-oleoyl-GPE (18:0/18:1)","methionine sulfone","3-hydroxystearate","N-acetylalanine","ursodeoxycholate","ergothioneine","alpha-tocopherol","quetiapine","succinimide","candesartan","O-sulfo-L-tyrosine","epiandrosterone sulfate","homocitrulline","2-hydroxyacetaminophen sulfate*","palmitoyl ethanolamide","N-stearoyltaurine","ascorbic acid 2-sulfate","pyrraline","N-methyltaurine","6-bromotryptophan","fructosyllysine","5alpha-androstan-3alpha,17beta-diol disulfate","cholate","threonate","enalapril","chenodeoxycholate","argininate*","N-acetylvaline","glycerol","3-methylhistidine","lysine","hyocholate","allantoin","gentisate","N6-methyladenosine","gamma-glutamyltryptophan","tyrosine","gamma-glutamylphenylalanine","1-linoleoyl-GPC (18:2)","2-aminobutyrate","alpha-hydroxyisovalerate","N-acetylalliin","vanillic alcohol sulfate","choline phosphate","deoxycholic acid glucuronide","1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)*","gulonate*","ginkgolic acid C15:1","maltose","succinate","3-hydroxystachydrine*","N-acetyltryptophan","N-delta-acetylornithine","sphinganine","3-amino-2-piperidone","N-acetylglucosaminylasparagine","mirtazapine","N6-acetyllysine","2-hydroxyoctanoate","phenylalanine","p-cresol sulfate","phosphate","fructose","N-acetyl-1-methylhistidine*","pyruvate","alpha-CEHC glucuronide*","fluconazole","3-(4-hydroxyphenyl)lactate","1-arachidonoyl-GPI (20:4)*","cysteine-glutathione disulfide","uracil","alpha-hydroxyisocaproate","2-hydroxyibuprofen","thymine","ethylmalonate","O-acetylhomoserine","cinnamoylglycine","5alpha-androstan-3beta,17beta-diol disulfate","1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0)*","theobromine","4-acetaminophen sulfate","sphinganine-1-phosphate","mannonate*","O-desmethyltramadol","catechol sulfate","isoleucine","myo-inositol","ranitidine N-oxide*","homostachydrine*","2-hydroxystearate","acisoga","gamma-glutamylthreonine","3-formylindole","N-acetylglycine","4-acetamidobutanoate","glycocholate","tramadol","1-(1-enyl-palmitoyl)-2-palmitoleoyl-GPC (P-16:0/16:1)*","N-acetylserine","imidazole lactate","carbamazepine","pregnanediol-3-glucuronide","N,O-didesmethylvenlafaxine glucuronide","N-acetylglutamate","homoarginine","N-ethylglycinexylidide","cotinine N-oxide","hydrochlorothiazide","3-methyl-2-oxobutyrate","diclofenac","dimethyl sulfone","umbelliferone sulfate","formiminoglutamate","glycochenodeoxycholate","3-hydroxyquinine","17alpha-hydroxypregnenolone 3-sulfate","3-aminoisobutyrate","gamma-glutamylmethionine","chlorzoxazone","glycochenodeoxycholate 3-sulfate","3,7-dimethylurate","glutamine","indomethacin","naproxen","choline","paraxanthine","fluoxetine","4-allylphenol sulfate","4-hydroxyglutamate","1-linoleoyl-GPI (18:2)*","3-(3-hydroxyphenyl)propionate","citraconate/glutaconate","1-stearoyl-2-linoleoyl-GPC (18:0/18:2)*","alpha-ketoglutaramate*","gamma-glutamylhistidine","ethyl glucuronide","kynurenate","2,3-dihydroxyisovalerate","3-hydroxysebacate","heme","EDTA","O-desmethylvenlafaxine","2-hydroxyphenylacetate","ferulic acid 4-sulfate","beta-alanine","N-acetyltaurine","gabapentin","indoleacetylglutamine","1-methylnicotinamide","duloxetine","aripiprazole","pregabalin","lithocholic acid sulfate (2)","glycerate","lamivudine","indoleacetate","2-aminoheptanoate","1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)*","citalopram N-oxide*","dihydroorotate","linoleoylcholine*","3-hydroxymyristate","O-desmethyltramadol glucuronide","3-hydroxy-2-ethylpropionate","2-hydroxylaurate","indolin-2-one","1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2)*","isoeugenol sulfate","4-vinylguaiacol sulfate","topiramate","N-acetylcitrulline","2-methoxyacetaminophen glucuronide*","N-formylanthranilic acid","1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6)","taurodeoxycholate","caffeic acid sulfate","N-acetylphenylalanine","N1-Methyl-2-pyridone-5-carboxamide","xanthurenate","pantoate","3-hydroxyoctanoate","3-(N-acetyl-L-cystein-S-yl) acetaminophen","quinine","4-methyl-2-oxopentanoate","3-hydroxydodecanedioate*","theanine","biliverdin","2-aminooctanoate","citrulline","glycoursodeoxycholate","gamma-CEHC","omeprazole","phenol glucuronide","androsterone sulfate","cysteine s-sulfate","3-hydroxylaurate","cotinine","riboflavin (Vitamin B2)","5-(galactosylhydroxy)-L-lysine","carbamazepine 10,11-epoxide*","7-methylxanthine","cholesterol sulfate","N-acetylasparagine","urea","2'-deoxyuridine","S-allylcysteine","palmitoyl dihydrosphingomyelin (d18:0/16:0)*","2-hydroxy-3-methylvalerate","solanidine","3b-hydroxy-5-cholenoic acid","1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4)*","isoleucylglycine","16-hydroxypalmitate","5-acetylamino-6-formylamino-3-methyluracil","glycolithocholate sulfate*","N-oleoylserine","N-acetylhistidine","acetoacetate","carnosine","N-methylproline","palmitoylcholine","1-stearoyl-2-arachidonoyl-GPC (18:0/20:4)","valine","ectoine","alpha-ketobutyrate","glycyrrhetinate","2-hydroxydecanoate","docosadienoate (22:2n6)","erythritol","N-acetyl-beta-alanine"],"pubmed_abstract":["Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas ( https://gutsyatlas.serve.scilifelab.se/ ). We exemplify the potential of this resource by presenting novel associations between dietary factors and oral medication with the gut microbiome, and microbial species strongly associated with the uremic toxin p-cresol sulfate. This resource can be used as the basis for targeted studies of perturbation of specific metabolites and for identification of candidate plasma biomarkers of gut microbiota composition."],"pubmed_title":["An online atlas of human plasma metabolite signatures of gut microbiome composition."],"pubmed_authors":["Dekkers Koen F KF, Sayols-Baixeras Sergi S, Baldanzi Gabriel G, Nowak Christoph C, Hammar Ulf U, Nguyen Diem D, Varotsis Georgios G, Brunkwall Louise L, Nielsen Nynne N, Eklund Aron C AC, Bak Holm Jacob J, Nielsen H Bjørn HB, Ottosson Filip F, Lin Yi-Ting YT, Ahmad Shafqat S, Lind Lars L, Sundström Johan J, Engström Gunnar G, Smith J Gustav JG, Ärnlöv Johan J, Orho-Melander Marju M, Fall Tove T"],"description_synonyms":["sodium salt, Biological Markers, Viral Marker, Bowel, BamF, Surrogate Endpoints, BamC, AP-2, Laboratory, para-cresol, Blood, alpha-Spe, Biochemical, Endpoint, Profiles, neutral molecular compounds, Serum, CG31654, alpha-Spc, Xrel2, School-Age, Readability, l(3)04276, Laboratory Markers, primary metabolites, 4-cresol, C-Rel, Biological, Associations, GRP1, Grp1, High Performance Liquid Chromatography, alpha-adaptin, Analysis, DmelCG10422, molecule, alpha-spec, molecula, Metabolic Profiles, imprinted and ancient gene protein, Mass Spectrum Analysis, average, Fresh Frozen Plasmas, Fresh Frozen, molecules, [SO4](2-), CG4260, Analyses, Moods, SULFATE ION, C1, PTPSTEP, Microbial Community Structure, alimentary tract, Molekuel, v-rel, ird, alpha-spectrin, HPLC, Immune, g, High-Performance, Markers, l(2)k08110, Viral Markers, Chromatography, Microbial Community Structures, High-Performance Liquid, asd, High Speed Liquid, adult alimentary canal, alimentary system, rel-A, REL, plasma, Inorganic, GPH, sulfate, Frozen Plasma, Sulfate dianion, Viral, l(3)neo36, Surrogate Endpoint, Liquid Chromatography, ham, Biochemical Markers, Normalcy, rel, Microbial, Plasmas, Biologic Marker, Spectrum Analysis, ada, Spectroscopy, Inorganic Sulfates, alphaSpec, D-Ada, tetraoxosulfate(2-), Marker, School Age, RENBP, 3.1.3.48, cg4260, dAP-2a, Sulfate anion(2-), Individual, spectrin, Microbial Communities, l(2)06694, MENE (2L)-A, Populations, AI747421, human gut microbiota, End Points, Microbial Community Compositions, Step, CG11628, Sulfates, Spectrometry, Striatum-enriched protein-tyrosine phosphatase, RELI, alpha, Immunologic, AP-2alpha, Laboratory Marker, DmelCG4260, AGE, Atlases, Composition, Health, STEP, gastrointestinal system, Biochemical Marker, metabolites, Liquid, School-Age Population, E430016J11Rik, Human Microbiomes, Community, Fresh, Microbial Community Composition, digestive canal, alpha-Ada, anon-EST:fe2E2, GRP1/cytohesin 1, l(3)alpha-Spec, ird4, Fresh Frozen Plasma, NF-kappaB, Clinical Markers, Clinical Marker, relish, alpha-Spect, aluminum salt, secondary metabolites, Spectrum Analyses, xrel, Ximpact, Normalcies, l(2)SH2 0460, SO4(2-), Human, fs(3)neo61, Surrogate End Points, CG11633, cytohesin/GRP1, CG10422, Surrogate Markers, Gus, alpha-ada, Gur, potassium salt, Gut, klo, Mass, Mood, alpha-Sp, tetraoxosulfate(VI), CG1977, Metabolic Profile, Mass Spectroscopy, CG11992, Normalities, study, School-Age Populations, Biomarker, Blood Plasma, gut, Clinical, Metabolomes, Profile, Biological Marker, l(2)SH2 0323, dre3, Population, Alpha-Adaptin, High-Performance Liquid Chromatographies, Immunologic Markers, Neural-specific protein-tyrosine phosphatase, Blood Plasmas, Ultra Performance Liquid Chromatography, UPLC, species, School Age Population, Immunologic Marker, intestines, Biologic, Human Microbiome, l(3)dre3, High-Performance Liquid Chromatography, Individual Health, Microbiome., Community Composition, alpha-Spectrin, c-Rel, 4-methylphenol, 3A9, RnBP, DmelCG1977, Affects, Serum Markers, GlcNAc 2-epimerase, End Point, stepk, p-cresol, sulphate, Rel-p110, impact-a, Immune Marker, Frozen Plasmas, Sulfate(2-), gut tube, N-acetyl-D-glucosamine 2-epimerase, MS, c-rel, Surrogate End Point, imprinted and ancient gene protein homolog, IMPACT, MENE(2L)-A, alphaSp, l(2)SH0323, Mass Spectrum Analyses, NFkappaB, Microbiome, Biologic Markers, CYH1, Plasma, Mass Spectrum, Serum Marker, Microbiomes, D-alphaAda, DmelCG11992, tetraoxidosulfate(2-), mating_type_alpha, Metabolic, Normality, Microbial Community, Surrogate, Endpoints, Community Structure, Gus-u, 2-D projection, FCP-B, Gus-t, metabolite, Gus-s, portion of plasma, Gus-r, Understanding, School Age Populations, Sulfuric acid ion(2-), Surrogate Marker, DmelCG11628, AP2, High Pressure, cross-sectional, l(3)62Bd, Bam-C, BAM, Bam, alpha mating type (yeast), l(2)SH0460, renin-binding protein, Microbiotas, alfa-Spec, High Performance Liquid, Rel/NF-kappaB, Sulfate, RWDD5, Spec, sulphate ion, Immune Markers"],"pubmed_title_synonyms":["Plasma, Fresh, Fresh Frozen Plasmas, Fresh Frozen, digestive canal, Blood Plasma, AI747421, Frozen Plasma, human being, Bowel, gut, Man (Taxonomy), Fresh Frozen Plasma, C1, Blood, Modern, Gus-u, alimentary tract, secondary metabolites, metabolite, Gus-t, portion of plasma, Gus-s, Gus-r, Plasmas, human, Atlases, Human, Frozen Plasmas, gut tube, Gus, primary metabolites, Gur, Gut, g, Homo sapiens, gastrointestinal system, intestines., Modern Man, Blood Plasmas, metabolites, asd, adult alimentary canal, alimentary system, Man, plasma"],"pubmed_abstract_synonyms":["sodium salt, Biological Markers, Viral Marker, Bowel, BamF, Surrogate Endpoints, BamC, AP-2, Laboratory, para-cresol, Blood, alpha-Spe, Biochemical, Endpoint, Profiles, neutral molecular compounds, Serum, CG31654, alpha-Spc, School-Age, Readability, l(3)04276, Laboratory Markers, primary metabolites, 4-cresol, Biological, Associations, GRP1, Grp1, High Performance Liquid Chromatography, alpha-adaptin, Analysis, DmelCG10422, molecule, alpha-spec, molecula, Metabolic Profiles, imprinted and ancient gene protein, Mass Spectrum Analysis, average, Fresh Frozen Plasmas, Fresh Frozen, molecules, [SO4](2-), CG4260, Analyses, Moods, SULFATE ION, C1, PTPSTEP, Microbial Community Structure, alimentary tract, Molekuel, alpha-spectrin, HPLC, Immune, g, High-Performance, Markers, l(2)k08110, Viral Markers, Chromatography, Microbial Community Structures, High-Performance Liquid, asd, High Speed Liquid, adult alimentary canal, alimentary system, plasma, Inorganic, GPH, sulfate, Frozen Plasma, Sulfate dianion, Viral, Surrogate Endpoint, Liquid Chromatography, ham, Biochemical Markers, Normalcy, Microbial, Plasmas, Biologic Marker, Spectrum Analysis, ada, Spectroscopy, Inorganic Sulfates, alphaSpec, D-Ada, tetraoxosulfate(2-), Marker, School Age, RENBP, 3.1.3.48, cg4260, dAP-2a, Sulfate anion(2-), Individual, spectrin, Microbial Communities, l(2)06694, MENE (2L)-A, Populations, AI747421, human gut microbiota, End Points, Microbial Community Compositions, Step, CG11628, Sulfates, Spectrometry, Striatum-enriched protein-tyrosine phosphatase, alpha, Immunologic, AP-2alpha, Laboratory Marker, DmelCG4260, AGE, Atlases, Composition, Health, STEP, gastrointestinal system, Biochemical Marker, metabolites, Liquid, School-Age Population, E430016J11Rik, Human Microbiomes, Community, Fresh, Microbial Community Composition, digestive canal, alpha-Ada, anon-EST:fe2E2, GRP1/cytohesin 1, l(3)alpha-Spec, Fresh Frozen Plasma, Clinical Markers, Clinical Marker, alpha-Spect, aluminum salt, secondary metabolites, Spectrum Analyses, Ximpact, Normalcies, l(2)SH2 0460, SO4(2-), Human, fs(3)neo61, Surrogate End Points, CG11633, cytohesin/GRP1, CG10422, Surrogate Markers, Gus, alpha-ada, Gur, potassium salt, Gut, klo, Mass, Mood, alpha-Sp, tetraoxosulfate(VI), CG1977, Metabolic Profile, Mass Spectroscopy, Normalities, study, School-Age Populations, Biomarker, Blood Plasma, gut, Clinical, Metabolomes, Profile, Biological Marker, l(2)SH2 0323, dre3, Population, Alpha-Adaptin, High-Performance Liquid Chromatographies, Immunologic Markers, Neural-specific protein-tyrosine phosphatase, Blood Plasmas, Ultra Performance Liquid Chromatography, UPLC, species, School Age Population, Immunologic Marker, intestines, Biologic, Human Microbiome, l(3)dre3, High-Performance Liquid Chromatography, Individual Health, Microbiome., Community Composition, alpha-Spectrin, 4-methylphenol, 3A9, RnBP, DmelCG1977, Affects, Serum Markers, GlcNAc 2-epimerase, End Point, stepk, p-cresol, sulphate, impact-a, Immune Marker, Frozen Plasmas, Sulfate(2-), gut tube, N-acetyl-D-glucosamine 2-epimerase, MS, Surrogate End Point, imprinted and ancient gene protein homolog, IMPACT, MENE(2L)-A, alphaSp, l(2)SH0323, Mass Spectrum Analyses, Microbiome, Biologic Markers, CYH1, Plasma, Mass Spectrum, Serum Marker, Microbiomes, D-alphaAda, tetraoxidosulfate(2-), mating_type_alpha, Metabolic, Normality, Microbial Community, Surrogate, Endpoints, Community Structure, Gus-u, 2-D projection, FCP-B, Gus-t, metabolite, Gus-s, portion of plasma, Gus-r, Understanding, School Age Populations, Sulfuric acid ion(2-), Surrogate Marker, DmelCG11628, AP2, High Pressure, cross-sectional, l(3)62Bd, Bam-C, BAM, Bam, alpha mating type (yeast), l(2)SH0460, renin-binding protein, Microbiotas, alfa-Spec, High Performance Liquid, Sulfate, RWDD5, Spec, sulphate ion, Immune Markers"],"name_synonyms":["Plasma, Fresh, Fresh Frozen Plasmas, Fresh Frozen, digestive canal, Blood Plasma, AI747421, Frozen Plasma, human being, Bowel, gut, Man (Taxonomy), Fresh Frozen Plasma, C1, Blood, Modern, Gus-u, alimentary tract, secondary metabolites, metabolite, Gus-t, portion of plasma, Gus-s, Gus-r, Plasmas, human, Atlases, Human, Frozen Plasmas, gut tube, Gus, primary metabolites, Gur, Gut, g, Homo sapiens, gastrointestinal system, intestines., Modern Man, Blood Plasmas, metabolites, asd, adult alimentary canal, alimentary system, Man, plasma"],"additional_accession":[]},"is_claimable":false,"name":"An online atlas of human plasma metabolite signatures of gut microbiome composition","description":"Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas (https://gutsyatlas.serve.scilifelab.se/). We exemplify the potential of this resource by presenting novel associations between dietary factors and oral medication with the gut microbiome, and microbial species strongly associated with the uremic toxin p-cresol sulfate. This resource can be used as the basis for targeted studies of perturbation of specific metabolites and for identification of candidate plasma biomarkers of gut microbiota composition.
","dates":{"publication":"2022-05-19","submission":"2019-01-11"},"accession":"MTBLS407","cross_references":{"MetaboLights":["MTBLC371","MTBLC16610","MTBLC16797","MTBLC72665","MTBLC30915","MTBLC18344","MTBLC18064","MTBLC16831","MTBLC17050","MTBLC16359","MTBLC18101","MTBLC27468","MTBLC17368","MTBLC72663","MTBLC16675","MTBLC17768","MTBLC16552","MTBLC21891","MTBLC29016","MTBLC22660","MTBLC28478","MTBLC17385","MTBLC26008","MTBLC16958","MTBLC15727","MTBLC17033","MTBLC26806","MTBLC16113","MTBLC18132","MTBLC16827","MTBLC16962","MTBLC16737","MTBLC4047","MTBLC17376","MTBLC16393","MTBLC28834","MTBLC17755","MTBLC16566","MTBLC18012","MTBLC73705","MTBLC24266","MTBLC15428","MTBLC17687","MTBLC16344","MTBLC27570","MTBLC17650","MTBLC16668","MTBLC17596","MTBLC17268","MTBLC24898","MTBLC37024","MTBLC18211","MTBLC25017","MTBLC25094","MTBLC6650","MTBLC16811","MTBLC17154","MTBLC18257","MTBLC16742","MTBLC28044","MTBLC26078","MTBLC26271","MTBLC78320","MTBLC17015","MTBLC16914","MTBLC17822","MTBLC28790","MTBLC15891","MTBLC16199","MTBLC16704","MTBLC16450","MTBLC30817","MTBLC18237","MTBLC28300","MTBLC26986","MTBLC27897","MTBLC27266","MTBLC17234","MTBLC30831","MTBLC17750","MTBLC15356","MTBLC37684","MTBLC17724","MTBLC16449","MTBLC18186","MTBLC17802","MTBLC32816","MTBLC17568","MTBLC18222","MTBLC17562","MTBLC22599","MTBLC68641","MTBLC27732","MTBLC28757","MTBLC16040","MTBLC17821","MTBLC17306","MTBLC22653","MTBLC30865","MTBLC18095","MTBLC15676","MTBLC15318","MTBLC16010","MTBLC28747","MTBLC15611","MTBLC7916","MTBLC17964","MTBLC36711","MTBLC33508","MTBLC18261","MTBLC166830","MTBLC21557","MTBLC169985","MTBLC16990","MTBLC30660","MTBLC82969","MTBLC72782","MTBLC22470","MTBLC40992","MTBLC17645","MTBLC27389","MTBLC16755","MTBLC30769","MTBLC35621","MTBLC17775","MTBLC9907","MTBLC71466","MTBLC73707","MTBLC15999","MTBLC73018","MTBLC17012","MTBLC17261","MTBLC15344","MTBLC16919","MTBLC133046","MTBLC133032","MTBLC19660","MTBLC16020","MTBLC17754","MTBLC15354","MTBLC30754","MTBLC68433","MTBLC172453","MTBLC5118","MTBLC46195","MTBLC7476","MTBLC37084","MTBLC5855","MTBLC71464","MTBLC73002","MTBLC73001","MTBLC36274","MTBLC16525","MTBLC28865","MTBLC9410","MTBLC6904","MTBLC133435","MTBLC32635","MTBLC91315","MTBLC741548","MTBLC17126","MTBLC30746","MTBLC30745","MTBLC132966","MTBLC10072","MTBLC35932","MTBLC49033","MTBLC70959","MTBLC60175","MTBLC44185","MTBLC15728","MTBLC24298","MTBLC15978","MTBLC27487","MTBLC28683","MTBLC17533","MTBLC16543","MTBLC48929","MTBLC18107","MTBLC15963","MTBLC27471","MTBLC28177","MTBLC17521","MTBLC28946","MTBLC17189","MTBLC25858","MTBLC24813","MTBLC43355","MTBLC82966","MTBLC48430","MTBLC83481","MTBLC37550","MTBLC75062","MTBLC59783","MTBLC18300","MTBLC133226","MTBLC86543","MTBLC37098","MTBLC39867","MTBLC58128","MTBLC27891","MTBLC17113","MTBLC66869","MTBLC131454","MTBLC32111","MTBLC85148","MTBLC17303","MTBLC16530","MTBLC27747","MTBLC58148","MTBLC7823","MTBLC132983","MTBLC15584","MTBLC42191","MTBLC40410","MTBLC33527","MTBLC26984","MTBLC24149","MTBLC27693","MTBLC16411","MTBLC70958","MTBLC37998","MTBLC83037","MTBLC43580","MTBLC82912","MTBLC68561","MTBLC68447","MTBLC62205","MTBLC36206","MTBLC132948","MTBLC68848","MTBLC7671","MTBLC89182","MTBLC131434","MTBLC89836","MTBLC89963","MTBLC133733","MTBLC82956","MTBLC145970","MTBLC16974","MTBLC1606","MTBLC17072","MTBLC32389","MTBLC73685","MTBLC70976","MTBLC21626","MTBLC138368","MTBLC72998","MTBLC40521","MTBLC28821","MTBLC28623","MTBLC45826","MTBLC81244","MTBLC83040","MTBLC86910","MTBLC133028","MTBLC35280","MTBLC60645","MTBLC166487","MTBLC15927","MTBLC82965","MTBLC82968","MTBLC82914","MTBLC37654","MTBLC133026","MTBLC165873","MTBLC30413","MTBLC28733","MTBLC48991","MTBLC691622","MTBLC68531","MTBLC68449","MTBLC68441","MTBLC32643","MTBLC80473","MTBLC68443","MTBLC19065","MTBLC19289","MTBLC70989","MTBLC21440","MTBLC25722","MTBLC8087","MTBLC71018","MTBLC23774","MTBLC19928","MTBLC143243","MTBLC70984","MTBLC145961","MTBLC2274","MTBLC20129","MTBLC27410","MTBLC68434","MTBLC133092","MTBLC27905","MTBLC73028","MTBLC64390","MTBLC6456","MTBLC222828","MTBLC89228","MTBLC5757","MTBLC73004","MTBLC83058","MTBLC49006","MTBLC65101","MTBLC24462","MTBLC70979","MTBLC73027","MTBLC71062","MTBLC68505","MTBLC81015","MTBLC36314","MTBLC1427","MTBLC27592","MTBLC83053","MTBLC73218","MTBLC9347","MTBLC17864","MTBLC16244","MTBLC183825","MTBLC7735","MTBLC176458","MTBLC17752","MTBLC17924","MTBLC5832","MTBLC82931","MTBLC82932","MTBLC82911","MTBLC68503","MTBLC604731","MTBLC53014","MTBLC82753","MTBLC133077","MTBLC133474","MTBLC133459","MTBLC82942","MTBLC82944","MTBLC133005","MTBLC133066","MTBLC133089","MTBLC178081","MTBLC50621","MTBLC45441","MTBLC75038","MTBLC23098","MTBLC133096","MTBLC74965","MTBLC73008","MTBLC16893","MTBLC3387","MTBLC3655","MTBLC90344","MTBLC10362","MTBLC133115","MTBLC133119","MTBLC166730","MTBLC166739","MTBLC133698","MTBLC133101","MTBLC133112","MTBLC40070","MTBLC17084","MTBLC89379","MTBLC16682","MTBLC78646","MTBLC70824","MTBLC87774","MTBLC89454","MTBLC35420","MTBLC4828","MTBLC24809","MTBLC133183","MTBLC16175","MTBLC68616","MTBLC3388","MTBLC36108","MTBLC30882","MTBLC6801","MTBLC88735","MTBLC17685","MTBLC15689","MTBLC37564","MTBLC43419","MTBLC28315","MTBLC7274","MTBLC28297","MTBLC26836","MTBLC30923","MTBLC32812","MTBLC29023","MTBLC18697","MTBLC61936","MTBLC89406","MTBLC71182","MTBLC89087","MTBLC7772","MTBLC2904","MTBLC5778","MTBLC8776","MTBLC45658","MTBLC28832","MTBLC28374","MTBLC28116","MTBLC9123","MTBLC41423","MTBLC42797","MTBLC9943","MTBLC7915","MTBLC8707","MTBLC80656","MTBLC87248","MTBLC30853","MTBLC86260","MTBLC89929","MTBLC80774","MTBLC137271","MTBLC55328","MTBLC15854","MTBLC133139","MTBLC133141","MTBLC50845","MTBLC188432","MTBLC146206","MTBLC74066","MTBLC74534","MTBLC132479","MTBLC138529","MTBLC77065","MTBLC15724","MTBLC64349","MTBLC86612","MTBLC73087","MTBLC47780","MTBLC7936","MTBLC36796","MTBLC51137","MTBLC6950","MTBLC88765","MTBLC2596","MTBLC61695","MTBLC39540","MTBLC21054","MTBLC9307","MTBLC180876","MTBLC25013","MTBLC133144","MTBLC84842","MTBLC51380","MTBLC101278","MTBLC5050","MTBLC9948","MTBLC67249","MTBLC176462","MTBLC133176","MTBLC52022","MTBLC15035","MTBLC133172","MTBLC133197","MTBLC133199","MTBLC83527","MTBLC10125","MTBLC10033","MTBLC89234","MTBLC133460","MTBLC75145","MTBLC47426","MTBLC9349","MTBLC5551","MTBLC77761","MTBLC133181","MTBLC31697","MTBLC133186","MTBLC89205","MTBLC133206","MTBLC87998","MTBLC74077","MTBLC40279","MTBLC44673","MTBLC133185","MTBLC133223","MTBLC36575","MTBLC133217","MTBLC133708","MTBLC132188","MTBLC133456","MTBLC133430","MTBLC24109","MTBLC46215","MTBLC133512","MTBLC133504","MTBLC84415","MTBLC136638","MTBLC149475","MTBLC133534","MTBLC133542","MTBLC133594","MTBLC133530","MTBLC133559","MTBLC48093","MTBLC133532","MTBLC133583","MTBLC133544","MTBLC88526","MTBLC133570","MTBLC133548","MTBLC3347","MTBLC133562","MTBLC87986","MTBLC83501","MTBLC165191","MTBLC9927","MTBLC133568","MTBLC133706","MTBLC133565","MTBLC74532","MTBLC37946","MTBLC37035","MTBLC81014","MTBLC165856","MTBLC9648","MTBLC165221","MTBLC169437","MTBLC172338","MTBLC165230","MTBLC17151","MTBLC28037","MTBLC36462","MTBLC72733","MTBLC64681","MTBLC64032","MTBLC75034","MTBLC74963","MTBLC84829","MTBLC73000","MTBLC50129","MTBLC50578","MTBLC36211","MTBLC31236","MTBLC64356","MTBLC4784","MTBLC68579","MTBLC78647","MTBLC47381","MTBLC40237","MTBLC135530","MTBLC78268","MTBLC84822","MTBLC74000","MTBLC73009","MTBLC78261","MTBLC78266","MTBLC84527","MTBLC84557","MTBLC77292","MTBLC3561","MTBLC84532","MTBLC74977","MTBLC84814","MTBLC84562","MTBLC133672","MTBLC90483","MTBLC64564","MTBLC133677","MTBLC134206","MTBLC8378","MTBLC2869","MTBLC133693","MTBLC133694","MTBLC90242","MTBLC6367","MTBLC28036","MTBLC19228","MTBLC19227","MTBLC165558","MTBLC136614","MTBLC166485","MTBLC8461","MTBLC140887","MTBLC3745","MTBLC46081","MTBLC80596","MTBLC80631","MTBLC80581","MTBLC165848","MTBLC73076","MTBLC165572","MTBLC145755","MTBLC1556","MTBLC165864","MTBLC134543","MTBLC28238","MTBLC168243","MTBLC2323","MTBLC76341","MTBLC77042","MTBLC168338","MTBLC89312","MTBLC176456","MTBLC47276","MTBLC43997","MTBLC176478","MTBLC167215","MTBLC137056","MTBLC133684","MTBLC80603","MTBLC80604","MTBLC80602","MTBLC169567","MTBLC4786","MTBLC188278","MTBLC83498","MTBLC180534","MTBLC173668","MTBLC68465","MTBLC5384","MTBLC50730","MTBLC6741","MTBLC6541","MTBLC41774","MTBLC73051","MTBLC89884","MTBLC5354","MTBLC137228","MTBLC180725","MTBLC30747","MTBLC27690","MTBLC49575","MTBLC9435","MTBLC49662","MTBLC63631","MTBLC44423","MTBLC8228","MTBLC41321","MTBLC3013","MTBLC84563","MTBLC9332","MTBLC6909","MTBLC31169","MTBLC45924","MTBLC63577"],"pubmed":["36151114"],"ChEBI":["CHEBI:371","CHEBI:16610","CHEBI:16797","CHEBI:72665","CHEBI:30915","CHEBI:18344","CHEBI:18064","CHEBI:16831","CHEBI:17050","CHEBI:16359","CHEBI:18101","CHEBI:27468","CHEBI:17368","CHEBI:72663","CHEBI:16675","CHEBI:17768","CHEBI:16552","CHEBI:21891","CHEBI:29016","CHEBI:22660","CHEBI:28478","CHEBI:17385","CHEBI:26008","CHEBI:16958","CHEBI:15727","CHEBI:17033","CHEBI:26806","CHEBI:16113","CHEBI:18132","CHEBI:16827","CHEBI:16962","CHEBI:16737","CHEBI:4047","CHEBI:17376","CHEBI:16393","CHEBI:28834","CHEBI:17755","CHEBI:16566","CHEBI:18012","CHEBI:73705","CHEBI:24266","CHEBI:15428","CHEBI:17687","CHEBI:16344","CHEBI:27570","CHEBI:17650","CHEBI:16668","CHEBI:17596","CHEBI:17268","CHEBI:24898","CHEBI:37024","CHEBI:18211","CHEBI:25017","CHEBI:25094","CHEBI:6650","CHEBI:16811","CHEBI:17154","CHEBI:18257","CHEBI:16742","CHEBI:28044","CHEBI:26078","CHEBI:26271","CHEBI:78320","CHEBI:17015","CHEBI:16914","CHEBI:17822","CHEBI:28790","CHEBI:15891","CHEBI:16199","CHEBI:16704","CHEBI:16450","CHEBI:30817","CHEBI:18237","CHEBI:28300","CHEBI:26986","CHEBI:27897","CHEBI:27266","CHEBI:17234","CHEBI:30831","CHEBI:17750","CHEBI:15356","CHEBI:37684","CHEBI:17724","CHEBI:16449","CHEBI:18186","CHEBI:17802","CHEBI:32816","CHEBI:17568","CHEBI:18222","CHEBI:17562","CHEBI:22599","CHEBI:68641","CHEBI:27732","CHEBI:28757","CHEBI:16040","CHEBI:17821","CHEBI:17306","CHEBI:22653","CHEBI:30865","CHEBI:18095","CHEBI:15676","CHEBI:15318","CHEBI:16010","CHEBI:28747","CHEBI:15611","CHEBI:7916","CHEBI:17964","CHEBI:36711","CHEBI:33508","CHEBI:18261","CHEBI:166830","CHEBI:21557","CHEBI:169985","CHEBI:16990","CHEBI:30660","CHEBI:82969","CHEBI:72782","CHEBI:22470","CHEBI:40992","CHEBI:17645","CHEBI:27389","CHEBI:16755","CHEBI:30769","CHEBI:35621","CHEBI:17775","CHEBI:9907","CHEBI:71466","CHEBI:73707","CHEBI:15999","CHEBI:73018","CHEBI:17012","CHEBI:17261","CHEBI:15344","CHEBI:16919","CHEBI:133046","CHEBI:133032","CHEBI:19660","CHEBI:16020","CHEBI:17754","CHEBI:15354","CHEBI:30754","CHEBI:68433","CHEBI:172453","CHEBI:5118","CHEBI:46195","CHEBI:7476","CHEBI:37084","CHEBI:5855","CHEBI:71464","CHEBI:73002","CHEBI:73001","CHEBI:36274","CHEBI:16525","CHEBI:28865","CHEBI:9410","CHEBI:6904","CHEBI:133435","CHEBI:32635","CHEBI:91315","CHEBI:741548","CHEBI:17126","CHEBI:30746","CHEBI:30745","CHEBI:132966","CHEBI:10072","CHEBI:35932","CHEBI:49033","CHEBI:70959","CHEBI:60175","CHEBI:44185","CHEBI:15728","CHEBI:24298","CHEBI:15978","CHEBI:27487","CHEBI:28683","CHEBI:17533","CHEBI:16543","CHEBI:48929","CHEBI:18107","CHEBI:15963","CHEBI:27471","CHEBI:28177","CHEBI:17521","CHEBI:28946","CHEBI:17189","CHEBI:25858","CHEBI:24813","CHEBI:43355","CHEBI:82966","CHEBI:48430","CHEBI:83481","CHEBI:37550","CHEBI:75062","CHEBI:59783","CHEBI:18300","CHEBI:133226","CHEBI:86543","CHEBI:37098","CHEBI:39867","CHEBI:58128","CHEBI:27891","CHEBI:17113","CHEBI:66869","CHEBI:131454","CHEBI:32111","CHEBI:85148","CHEBI:17303","CHEBI:16530","CHEBI:27747","CHEBI:58148","CHEBI:7823","CHEBI:132983","CHEBI:15584","CHEBI:42191","CHEBI:40410","CHEBI:33527","CHEBI:26984","CHEBI:24149","CHEBI:27693","CHEBI:16411","CHEBI:70958","CHEBI:37998","CHEBI:83037","CHEBI:43580","CHEBI:82912","CHEBI:68561","CHEBI:68447","CHEBI:62205","CHEBI:36206","CHEBI:132948","CHEBI:68848","CHEBI:7671","CHEBI:89182","CHEBI:131434","CHEBI:89836","CHEBI:89963","CHEBI:133733","CHEBI:82956","CHEBI:145970","CHEBI:16974","CHEBI:1606","CHEBI:17072","CHEBI:32389","CHEBI:73685","CHEBI:70976","CHEBI:21626","CHEBI:138368","CHEBI:72998","CHEBI:40521","CHEBI:28821","CHEBI:28623","CHEBI:45826","CHEBI:81244","CHEBI:83040","CHEBI:86910","CHEBI:133028","CHEBI:35280","CHEBI:60645","CHEBI:166487","CHEBI:15927","CHEBI:82965","CHEBI:82968","CHEBI:82914","CHEBI:37654","CHEBI:133026","CHEBI:165873","CHEBI:30413","CHEBI:28733","CHEBI:48991","CHEBI:691622","CHEBI:68531","CHEBI:68449","CHEBI:68441","CHEBI:32643","CHEBI:80473","CHEBI:68443","CHEBI:19065","CHEBI:19289","CHEBI:70989","CHEBI:21440","CHEBI:25722","CHEBI:8087","CHEBI:71018","CHEBI:23774","CHEBI:19928","CHEBI:143243","CHEBI:70984","CHEBI:145961","CHEBI:2274","CHEBI:20129","CHEBI:27410","CHEBI:68434","CHEBI:133092","CHEBI:27905","CHEBI:73028","CHEBI:64390","CHEBI:6456","CHEBI:222828","CHEBI:89228","CHEBI:5757","CHEBI:73004","CHEBI:83058","CHEBI:49006","CHEBI:65101","CHEBI:24462","CHEBI:70979","CHEBI:73027","CHEBI:71062","CHEBI:68505","CHEBI:81015","CHEBI:36314","CHEBI:1427","CHEBI:27592","CHEBI:83053","CHEBI:73218","CHEBI:9347","CHEBI:17864","CHEBI:16244","CHEBI:183825","CHEBI:7735","CHEBI:176458","CHEBI:17752","CHEBI:17924","CHEBI:5832","CHEBI:82931","CHEBI:82932","CHEBI:82911","CHEBI:68503","CHEBI:604731","CHEBI:53014","CHEBI:82753","CHEBI:133077","CHEBI:133474","CHEBI:133459","CHEBI:82942","CHEBI:82944","CHEBI:133005","CHEBI:133066","CHEBI:133089","CHEBI:178081","CHEBI:50621","CHEBI:45441","CHEBI:75038","CHEBI:23098","CHEBI:133096","CHEBI:74965","CHEBI:73008","CHEBI:16893","CHEBI:3387","CHEBI:3655","CHEBI:90344","CHEBI:10362","CHEBI:133115","CHEBI:133119","CHEBI:166730","CHEBI:166739","CHEBI:133698","CHEBI:133101","CHEBI:133112","CHEBI:40070","CHEBI:17084","CHEBI:89379","CHEBI:16682","CHEBI:78646","CHEBI:70824","CHEBI:87774","CHEBI:89454","CHEBI:35420","CHEBI:4828","CHEBI:24809","CHEBI:133183","CHEBI:16175","CHEBI:68616","CHEBI:3388","CHEBI:36108","CHEBI:30882","CHEBI:6801","CHEBI:88735","CHEBI:17685","CHEBI:15689","CHEBI:37564","CHEBI:43419","CHEBI:28315","CHEBI:7274","CHEBI:28297","CHEBI:26836","CHEBI:30923","CHEBI:32812","CHEBI:29023","CHEBI:18697","CHEBI:61936","CHEBI:89406","CHEBI:71182","CHEBI:89087","CHEBI:7772","CHEBI:2904","CHEBI:5778","CHEBI:8776","CHEBI:45658","CHEBI:28832","CHEBI:28374","CHEBI:28116","CHEBI:9123","CHEBI:41423","CHEBI:42797","CHEBI:9943","CHEBI:7915","CHEBI:8707","CHEBI:80656","CHEBI:87248","CHEBI:30853","CHEBI:86260","CHEBI:89929","CHEBI:80774","CHEBI:137271","CHEBI:55328","CHEBI:15854","CHEBI:133139","CHEBI:133141","CHEBI:50845","CHEBI:188432","CHEBI:146206","CHEBI:74066","CHEBI:74534","CHEBI:132479","CHEBI:138529","CHEBI:77065","CHEBI:15724","CHEBI:64349","CHEBI:86612","CHEBI:73087","CHEBI:47780","CHEBI:7936","CHEBI:36796","CHEBI:51137","CHEBI:6950","CHEBI:88765","CHEBI:2596","CHEBI:61695","CHEBI:39540","CHEBI:21054","CHEBI:9307","CHEBI:180876","CHEBI:25013","CHEBI:133144","CHEBI:84842","CHEBI:51380","CHEBI:101278","CHEBI:5050","CHEBI:9948","CHEBI:67249","CHEBI:176462","CHEBI:133176","CHEBI:52022","CHEBI:15035","CHEBI:133172","CHEBI:133197","CHEBI:133199","CHEBI:83527","CHEBI:10125","CHEBI:10033","CHEBI:89234","CHEBI:133460","CHEBI:75145","CHEBI:47426","CHEBI:9349","CHEBI:5551","CHEBI:77761","CHEBI:133181","CHEBI:31697","CHEBI:133186","CHEBI:89205","CHEBI:133206","CHEBI:87998","CHEBI:74077","CHEBI:40279","CHEBI:44673","CHEBI:133185","CHEBI:133223","CHEBI:36575","CHEBI:133217","CHEBI:133708","CHEBI:132188","CHEBI:133456","CHEBI:133430","CHEBI:24109","CHEBI:46215","CHEBI:133512","CHEBI:133504","CHEBI:84415","CHEBI:136638","CHEBI:149475","CHEBI:133534","CHEBI:133542","CHEBI:133594","CHEBI:133530","CHEBI:133559","CHEBI:48093","CHEBI:133532","CHEBI:133583","CHEBI:133544","CHEBI:88526","CHEBI:133570","CHEBI:133548","CHEBI:3347","CHEBI:133562","CHEBI:87986","CHEBI:83501","CHEBI:165191","CHEBI:9927","CHEBI:133568","CHEBI:133706","CHEBI:133565","CHEBI:74532","CHEBI:37946","CHEBI:37035","CHEBI:81014","CHEBI:165856","CHEBI:9648","CHEBI:165221","CHEBI:169437","CHEBI:172338","CHEBI:165230","CHEBI:17151","CHEBI:28037","CHEBI:36462","CHEBI:72733","CHEBI:64681","CHEBI:64032","CHEBI:75034","CHEBI:74963","CHEBI:84829","CHEBI:73000","CHEBI:50129","CHEBI:50578","CHEBI:36211","CHEBI:31236","CHEBI:64356","CHEBI:4784","CHEBI:68579","CHEBI:78647","CHEBI:47381","CHEBI:40237","CHEBI:135530","CHEBI:78268","CHEBI:84822","CHEBI:74000","CHEBI:73009","CHEBI:78261","CHEBI:78266","CHEBI:84527","CHEBI:84557","CHEBI:77292","CHEBI:3561","CHEBI:84532","CHEBI:74977","CHEBI:84814","CHEBI:84562","CHEBI:133672","CHEBI:90483","CHEBI:64564","CHEBI:133677","CHEBI:134206","CHEBI:8378","CHEBI:2869","CHEBI:133693","CHEBI:133694","CHEBI:90242","CHEBI:6367","CHEBI:28036","CHEBI:19228","CHEBI:19227","CHEBI:165558","CHEBI:136614","CHEBI:166485","CHEBI:8461","CHEBI:140887","CHEBI:3745","CHEBI:46081","CHEBI:80596","CHEBI:80631","CHEBI:80581","CHEBI:165848","CHEBI:73076","CHEBI:165572","CHEBI:145755","CHEBI:1556","CHEBI:165864","CHEBI:134543","CHEBI:28238","CHEBI:168243","CHEBI:2323","CHEBI:76341","CHEBI:77042","CHEBI:168338","CHEBI:89312","CHEBI:176456","CHEBI:47276","CHEBI:43997","CHEBI:176478","CHEBI:167215","CHEBI:137056","CHEBI:133684","CHEBI:80603","CHEBI:80604","CHEBI:80602","CHEBI:169567","CHEBI:4786","CHEBI:188278","CHEBI:83498","CHEBI:180534","CHEBI:173668","CHEBI:68465","CHEBI:5384","CHEBI:50730","CHEBI:6741","CHEBI:6541","CHEBI:41774","CHEBI:73051","CHEBI:89884","CHEBI:5354","CHEBI:137228","CHEBI:180725","CHEBI:30747","CHEBI:27690","CHEBI:49575","CHEBI:9435","CHEBI:49662","CHEBI:63631","CHEBI:44423","CHEBI:8228","CHEBI:41321","CHEBI:3013","CHEBI:84563","CHEBI:9332","CHEBI:6909","CHEBI:31169","CHEBI:45924","CHEBI:63577"]}}