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S_D1.wiff.scanftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS4270/FILES/POS_A3.wiffprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS4270<p>Metabolites were identified using Progenesis QI (Waters Corporation, Milford, USA) data processing software, based on public databases such as http://www.hmdb.ca, http://www.lipidmaps.org and self-built databases.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse phaseLiquid Chromatography MS - positive - reverse phase<p>The analysis instrument of metabolic profiling was the AB Exion LC system (AB SCIEX, Framingham, MA) coupled with an AB SCIEX Triple TOF 6600 System (AB SCIEX, Framingham, MA). An ACQUITY UPLC BEH C18 column (1.7 μm, 2.1 x 100 mm) were employed in both positive and negative modes.</p>Dietary ε-polylysine effects on gut microbiota and plasma metabolites profiling in mice.Zhang XueleiInstitute of Bast Fiber Crops,Chinese Academy of Agricultural Sciencesblood plasmamass spectrometry<p>Plasma samples (100 μL) were added into 10 μL internal standard (2-chloro-l-phenylalanine in methanol, 0.3 mg/mL) dissolved in methanol, and vortexed for 10 s. Then, the mixtures were vortexed for 1 min with 300 μL mixture of methanol and acetonitrile (2/1, v/v). All samples were ultrasonicated at 25-28 °C for 10 min and stored at -20 °C for 30 min. The extract was centrifuged at 13,000 rpm at 4 °C for 15 min. The supernatant (300 mL) was dried in a freeze-concentration centrifugal dryer. A mixture of 400 μL methanol and water (1/4, v/v) was added to each sample, then vortexed for 30 s, and placed at 4 °C for 2 min. Samples were centrifuged at 13,000 rpm at 4 °C for 5 min. The supernatant (150 μL) from each tube was collected using crystal syringes, filtered through 0.22 μm microfilters and transferred to LC vials.</p>Mus musculushttps://www.ebi.ac.uk/metabolights/MTBLS4270Duanqin Wu.Xuelei Zhang. zhangxuelei1020@126.com.<p>The acquired LC-MS raw data were analyzed using Progenesis QI software (Waters Corporation, Milford, USA). </p>Treatmentbiological replicatezhangxuelei1020@126.com<p>Plasma from male adult C57 mice, stored -80 °C until analysis</p><p>Mice in each group (n=20) were fed the same diet (AIN-76A) supplemented with 0 (group A), 300 (group B), 600 (group C) and 1200 (group D) mg/kg ε-polylysine.</p>Metabolomicsultra-performance liquid chromatography-mass spectrometryPolylysineC57BL/6Jultra-performance liquid chromatography-mass spectrometryPolylysineC57BL/6J<p>The analysis instrument of metabolic profiling was the AB Exion LC system (AB SCIEX, Framingham, MA) coupled with an AB SCIEX Triple TOF 6600 System (AB SCIEX, Framingham, MA). An ACQUITY UPLC BEH C18 column (1.7 μm, 2.1 x 100 mm) were employed in both positive and negative modes.</p>falseDietary ε-polylysine effects plasma metabolites profiling in mice<p>Dietary ε-polylysine effects on gut microbiota and plasma metabolites profiling in mice. Owing to the effect of ε-polylysine on microorganisms and phospholipid metabolism, we aimed to establish a comprehensive overview of microbial colonization affecting plasma glycerophospholipid metabolism in C57 mice. In this study, we performed 16S rDNA analysis and metabolome analysis to systematically investigate the influence of the food additive ε-polylysine on the intestinal microflora and glycerophospholipid metabolism in C57 mice. We aimed to provide important data for the development and application of food additives to improve the safety of human food products.</p><p><br></p><p><strong>Plasma metabolomics</strong> is reported in the current study <a href='https://www.ebi.ac.uk/metabolights/MTBLS4270' rel='noopener noreferrer' target='_blank'><strong>MTBLS4270</strong></a>.</p><p><strong>Liver metabolomics</strong> is reported in <a href='https://www.ebi.ac.uk/metabolights/MTBLS4273' rel='noopener noreferrer' target='_blank'><strong>MTBLS4273</strong></a>.</p>2025-04-142022-02-08MTBLS4270