MetaboLightsapplication/xmlftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/m_MTBLS9769_LC-MS_negative_reverse-phase_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/m_MTBLS9769_LC-MS_positive_reverse-phase_metabolite_profiling_v2_maf.tsvftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/Table S3.xlsxftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/a_MTBLS9769_LC-MS_positive_reverse-phase_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/i_Investigation.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/s_MTBLS9769.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/a_MTBLS9769_LC-MS_negative_reverse-phase_metabolite_profiling.txtftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_QC01.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_WHM5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_WHM4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_WHM1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_UHW4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_UHW4.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_UHW1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_WHM3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_QC02.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_QC01.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_WHM1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_WHM6.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_UHW5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_WHM2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_WHM2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_UHW5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_QC02.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_WHM6.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_UHW2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_UHW6.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_UHW1.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_UHW6.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_WHM3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_QC03.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_QC03.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_WHM5.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_UHW3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_UHW2.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/POS/POS_Fl14WJ_UHW3.rawftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769/FILES/RAW_FILES/NEG/NEG_Fl14WJ_WHM4.rawprimaryOK200ftp://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS9769<p>The metabolites were identified by searching database, and the main databases were the HMDB (http://www.hmdb.ca/), Metlin (https://metlin.scripps.edu/) and Majorbio Database.</p>MetaboLightsPublicLiquid Chromatography MS - negative - reverse phaseLiquid Chromatography MS - positive - reverse phase<p>The LC-MS/MS analysis of sample was conducted on a Thermo UHPLC-Q Exactive HF-X system equipped with an ACQUITY HSS T3 column (100 mm x 2.1 mm i.d., 1.8 μm; Waters, USA) at Majorbio Bio-Pharm Technology Co. Ltd (Shanghai, China). The mobile phases consisted of 0.1% formic acid in water:acetonitrile (95:5, v/v) (solvent A) and 0.1% formic acid in acetonitrile:isopropanol:water (47.5:47.5, v/v) (solvent B). The flow rate was 0.40 mL/min.</p>Metabolomics analysis of the algU mutant strain under hyperosmotic stress.Keai DuoJiangsu UniversityWhole Organismmass spectrometry<p>Briefly, 50 mg solid sample was added to a 2 mL centrifuge tube and a 6 mm diameter grinding bead was added. In total 400 μL of extraction solution (methanol:water, 4:1, v:v) containing 0.02 mg/mL of internal standard (L-2-chlorophenylalanine) was used for metabolite extraction. Samples were ground by the Wonbio-96c (Shanghai wanbo biotechnology co., LTD) frozen tissue grinder for 6 min (-10 °C, 50 Hz), followed by low-temperature ultrasonic extraction for 30 min (5 °C, 40 kHz). The samples were left at -20 °C for 30 min, centrifuged for 15 min (4 °C, 13,000 x g), and the supernatant was transferred to the injection vial for LC-MS/MS analysis.</p>Pseudomonas protegens<p>The pretreatment of LC-MS raw data was performed by Progenesis QI (Waters Corporation, Milford, USA) software, and a 3D data matrix in CSV format was exported. The information in this 3D matrix included: sample information, metabolite name and mass spectral response intensity. Internal standard peaks, as well as any known false positive peaks (including noise, column bleed and derivatized reagent peaks), were removed from the data matrix, deredundant and peak pooled. At the same time, the metabolites were identified by searching database, and the main databases were the HMDB (http://www.hmdb.ca/), Metlin (https://metlin.scripps.edu/) and Majorbio Database.</p>Hyperosmotic stressmichelle_dai99@126.comhttps://www.ebi.ac.uk/metabolights/MTBLS9769<p>Strains were grown to early logarithmic phase in NB medium added with 400 mM NaCl at 30. Cells of 6 biological replicates were collected and washed twice by isosmotic NaCl solution.</p>MetabolomicsMetabolomicshyperosmotic stressalgUMetabolomicshyperosmotic stressalgU<p>The mass spectrometric data were collected using a Thermo UHPLC-Q Exactive HF-X Mass Spectrometer equipped with an electrospray ionization (ESI) source operating in positive mode and negative mode. The optimal conditions were set as followed: source temperature at 425 °C; sheath gas flow rate at 50 arb; Aux gas flow rate at 13 arb; ion-spray voltage floating (ISVF) at -3500 V in negative mode and 3500 V in positive mode, respectively; Normalized collision energy, 20-40-60 V rolling for MS/MS. Full MS resolution was 60000, and MS/MS resolution was 7500. Data acquisition was performed with the Data Dependent Acquisition (DDA) mode. The detection was carried out over a mass range of 70-1050 m/z.</p>G-Glu-Val4-HydroxynonenalPhenylacetylglutamineRiboflavinL-RhamnuloseMetyrapolDimethylethylamine-N-oxide3H-DopamineSitosterol 3-O-(6'-O-stearyl-beta-D-glucoside)Lablaboside CDeoxyinosineMorpholine-4-carboxamideProlylproline2-Butyne-1,4-diolSemidehydroascorbic acidL-Histidine1-NonanolTyrosylhydroxyprolineCitrullinePC(16:0/0:0)PS(15:0/20:4(5Z,8Z,11Z,14Z)-OH(19S))PE(18:1(11Z)/14:0)L-ProlinePaxillinePhenol(5Z,8Z,11Z,13E,15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoylcarnitinePolyoxyethylene 40 monostearatePheophorbide a18-Carboxy-dinor-LTE42-FuranmethanolImidazolineNeomycin(+/-)-(Z)-2-(5-Tetradecenyl)cyclobutanonePteroyltriglutamic acid5-Hydroxyindoleacetic acidBis(N-pantothenylamidoethyl) disulfideFurfural(E)-4-[[(1R)-2-[[(2R)-2-(2-Adamantyloxycarbonylamino)-3-(1H-indol-3-yl)-2-methylpropanoyl]amino]-1-phenylethyl]amino]-4-oxobut-2-enoic acidCinnamic acid5-(3-Methyl-1-triazeno)imidazole-4-carboxamidePE(20:1(11Z)/14:1(9Z))1,2,3-TrihydroxybenzeneIndole-3-acetylglutamic acidN2-Succinyl-L-ornithinePhthalic AcidSclareolLacto-N-biose I4-Propylphenol17-Ethynyl-16-fluoroestradiol(2S,3S,5R)-5-(6-Aminopurin-9-yl)-2-(2H-oxet-2-yl)oxolan-3-olSarmentosinN-MethylanilineGlyciteinEthyl-4-hydroxymethyl-3(2H)-FuranoneL-phenylalanyl-L-prolineSolutol HS 152-[(2-Fluorophenyl)methyl]-3-(2-fluorospiro[6,7-dihydrothieno[3,2-c]pyran-4,4'-piperidine]-1'-yl)butanamideDG(PGE2/0:0/18:0)LinatineLysoPE(16:1(9Z)/0:0)Phloretin-2'-O-(2''-O-xylosylglucoside)OleamideN,N-Dimethyldodecylamine-N-oxideCis-QuinceoxepaneBay 41-2272DemeclocyclineIsocitric AcidZomepirac1-(5-Hydroxy-2-oxo-2,3-dihydroimidazol-4-yl)ureaPE(16:1(9Z)/16:1(9Z))(+/-)-3-(4-Hydroxyphenyl)-1,2-propanediol 4'-O-glucosideTriethylenemelamineErucic acid1-PalmitoylphosphatidylcholineTebupirimfosN-hydroxy-L-tryptophan5-Hydroxyferulic acidADPMercaptoacetic acidPE(18:1/0:0)S-(2-Carboxyethyl)-L-cysteineTaxineMorphSalbutamolBipindogulomethylosideGlyceric acidFormetanate5-(4-Hydroxybenzyl)thiazolidine-2,4-dioneZilascorb1,4-Benzenediol, 2,5-bis(1-pyrazolyl)-4-hydroxy-5-methyl-2-propyl-3(2H)-furanoneCoproporphyrin IGentamicin CL-3-CyanoalanineDG(16:0/18:0/0:0)Fenvalerate2-MethylindoleEstramustine phosphateEpsilon-(Hexanoyl)lysineHomogentisic AcidPE(18:0/14:1(9Z))PE(17:1(9Z)/0:0)Indole3'-Adenylic AcidMethylprednisolone acetate6-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydroimidazo[1,2-c]pyrimidin-5-oneBOX AFluoroacetamideIsoketocamphoric acidIsoxanthopterinIsopentenyladenineLeu Pro Asn5-Methyl-2-furaldehydeL-CarnitineVenlafaxineGlutaminylarginine(+/-)-trans-and cis-2-Hexenal propylene glycol acetalAdenosine4-Trimethylammoniobutanoic AcidL-Glutamic gamma-semialdehydeLysoSM(d18:0)N-Acetyl-D-mannosamineAniracetam5-Acetamidovalerate2-Hydroxycinnamic acidS-(3-Oxo-3-carboxy-n-propyl)cysteineCis-DihydrocarvoneGlycylprolylhydroxyprolineIsopimpinellin2,6-diamino-4-hydroxy-5-formamidopyrimidineP-HydroxyubenimexKinetensin 1-3Pro Val GluSucroseStearidonic acidPA(PGE1/10:0)SagopiloneArginylphenylalaninamide21-Deoxycortisone(-)-trans-3,4-Dihydro-4,8-dihydroxy-3-methyl-1H-2-benzopyran-1-one1-DeoxynojirimycinN-Acetyl-D-galactosamineStrictosidine(R)-1-O-[b-D-Apiofuranosyl-(1->2)-b-D-glucopyranoside]-1,3-octanediolBeta-Glycerophosphoric acidSpermidineCGMPPelubiprofenQUISQUALIC ACIDPA(18:1(9Z)/15:0)MG(20:3(6,8,11)-OH(5)/0:0/0:0)(2R)-2-Methylpyrrolidine-1-carboxylic acid3-[[(2S)-2,4-Dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acidM-XyleneIsodeoxycholic acidN-Undecanoylglycine(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-olZeatin2-Amino-2,3,6,7-tetrahydro-1H-pteridin-4-one4-ene-Valproic acid1-Hydroxy-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid methyl esterProstavasinPentaerythritol mononitrateN(6)-Methyllysine6-Carboxy-5,6,7,8-tetrahydropterin5'-Deoxy-5'-fluorouridineN1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazoleConvallosideDelta-ValerolactoneMeperidineGuanine5'-MethylthioadenosineDL-GlutamateNADH4-MethylumbelliferoneGlu Asp LysAcetophenone2-HydroxypyridineIbuprofen glucuronideDecyl alcoholSclareol oxide1-O-Isopentyl-3-O-octadec-2-enoyl glycerolDioctyl sebacate2,3-DihydroxycarbamazepineValnemulinPermetin A3-ketosphingosineProxyphyllinePro Asn LeuGly Pro ValUridine 5'-monophosphate1,2-Dihydronaphthalene-1,2-diol7-Methylguanine2-Methylpyridine5-Hydroxypentanoic acid5-Aminopentanoic acidGlycyl-leucineClindamycin phosphateNAD+PS(16:1(9Z)/6 keto-PGF1alpha)Pro Gly LeuFAPy-adenine3-Phenyl-1H-pyrazole-4-carbaldehyde4-Amino-4-deoxyarabinoseCinobufaginDG(20:1(11Z)/16:1(9Z)/0:0)5-FluorouridineBetaineDG(16:1(9Z)/16:1(9Z)/0:0)N-Methyl-L-ProlineN-methylsphingosinePipecolic AcidN-Epsilon-Acetyl-L-LysineGly Val GluC-2 CeramideFloionolic acidPyochelin2-Cyclopentene-1,4-dioneGeniposide(R)-(+)-2-Pyrrolidone-5-carboxylic acidCucurbic acidPsilostachyinVal ValGalactosylhydroxylysineKBT 1585 hydrochlorideEthenodeoxyadenosineDG(16:1(9Z)/16:0/0:0)12-Oxo-2,3-dinor-10,15-phytodienoic acidLysoPA(i-19:0/0:0)4-Amino-1-butanol4-Ethyl-2,5-dimethyloxazole10-Hydroxydecanoic acidAllysinePhenethyl rutinosideSphinganineSecologanateLunatone1-(4-Hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-3,5-heptanediol1'-Acetoxychavicol acetateGamma-L-Glutamyl-gamma-L-glutamyl-L-methionineKAPA1H-Pyrazolo[3,4-d]pyrimidin-4-amine13,16,19-Docosatrienoic acidHistidinohydroxylysinonorleucine1-AMINOCYCLOBUTANE CARBOXYLIC ACIDErinapyrone AErinapyrone BThiodiacetic acid3-[[3-Methoxy-5-(1H-pyrrol-2-yl)pyrrol-2-ylidene]methyl]-1,4-dimethyl-4,5,6,7-tetrahydro-2H-isoindoleDL-p-Chlorophenylalanine methyl ester hydrochloridePro Thr Leu4-HydroxyisoleucineFarnesyl acetoneTherafectinEthyl 3-hydroxydodecanoate22-Hydroxydocosanoic acid4-Amino-1-piperidinecarboxylic acidAllantoinAmastatinGamma-Glutamylcysteine3-Buten-1-olFlumethasoneAzacosterol1-Methoxy-2-propylamineActein(3S,4R,5R)-1,3,4,5,6-Pentahydroxy-1-morpholin-4-ylhexan-2-oneN'-FormylkynurenineL-Threonine8-Amino-7-oxononanoic acidHaloperidol glucuronideNetilmicinTrigonellineMenthyl ethylene glycol carbonate5-Methyl-4-((1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-1,3-benzenediolLeukotriene E4Dioctyl succinateGlutamylglutamic acidStyrenePerilloside BBiguanideFAHFA(16:0/12-O-18:0)Tuliposide AL-Tyrosine Methyl EsterButylisopropylaminePro ValCinncassiol ASuspensolide F2-Amino-6-methoxypurineLauryldiethanolamineEthyl lysineQuinaldic acidArginine ornithineL-Norleucine11-Meo-fesTriethanolaminePE(16:0/16:1(9Z))EthylsulfenateSquamoloneMJDBISSP00000002DopamineSAPERCONAZOLE(17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-oneDicrocinMJDBISSP00000001Penciclovir5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB]Pro Ile GlyThienamycinMJDBISSP00000009GHB-GlucN,N,N',N',N'',N''-Hexakis(methoxymethyl)-1,3,5-triazine-2,4,6-triaminePro Leu Leu(E)-Zeatin glucoside5-Hydroxymethyl-2-furancarboxaldehydePro Pro IleCyclic ADP-RiboseN-AcetylmannosamineSequoyitolN1-(alpha-D-ribosyl)-5,6-dimethyl-benzimidazoleTrolamineHexylamineL-ValineDomoic acidUracil2-n-Propylthiazolidine-4-carboxylic acid2-Amino-2-methyl-1-propanolNorleucineHomovanillic AcidPA(20:2(11Z,14Z)/15:0)CreatineMimosineL-Glutamic AcidTrans-Cinnamic AcidCytosinePalmitoyl glucuronide(3-Aminopropyl)(n-butyl)phosphinic acid3-Succinoylpyridine2',3'-DideoxyguanosineIle Pro GlnThiazolinePantetheine 4'-phosphate3-[(2-oxoacetyl)oxy]-4-(trimethylazaniumyl)butanoate-CoA5'-Guanylic AcidVal Glu3,3'-Thiobispropanoic acidTaxifolin 3-arabinosideBenzoylaconine9(S)-HODELysylproline11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate12-oxo-PDACyclohexaneAcetic acidD-Biotin3-Hydroxy-5,5,8a-Trimethyl-3,4,4a,6,7,8-Hexahydronaphthalene-2-Carboxylic AcidKynurenic Acid(6S)-Tetrahydro-L-biopterinPro Asp IleAlpha-Methylene-gamma-butyrolactone(2S,3S,4S,5R)-3,4,5-Trihydroxy-6-sulfooxyoxane-2-carboxylic acidGalactosylsphingosineUmbelliferose(R)-Rutaretin 1'-(6''-sinapoylglucoside)(2S)-2-Amino-6-[(3-formylpiperidin-1-yl)amino]hexanoic acidHarmaline17-N,N-Diethylcarbamoyl-4-methyl-4-azaandrostane-3-oneDimethylamino-ethanolGlycerol 2-phosphateGlycerophosphoinositol1-[Ethyl-(6-hydrazinylpyridazin-3-yl)amino]propan-2-ol3-Methoxypropylamine7-Aminomethyl-7-carbaguanine20-Cooh ltb4Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide(3Z)-2-Propylpent-3-enoic acidInosineAla Leu AlaSulfolithocholylglycineLumichromePro Pro Val2-Phenylethanol glucuronideUridine monophosphate (UMP)PE(18:3(9Z,12Z,15Z)/16:0)1-Deoxy-1-morpholino-D-fructose1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-oneDimethylethanolamine3-Hydroxy-4-aminopyridineN-gamma-Glutamylcysteine ethyl esterHydroxyprolyl-Arginine[3-[2-Aminoethoxy(hydroxy)phosphoryl]oxy-2-hydroxypropyl] hexadecanoatePalmitic acid4,5-DihydrovomifoliolChenodeoxycholylasparagineGentiopicroside5-Aminovaleric AcidLucidenic acid FAnserineGlucosyl (2E,6E,10x)-10,11-dihydroxy-2,6-farnesadienoatePE(16:1(9Z)/P-18:1(9Z))Dimethyl SulfoxideP-TolualdehydeMETHACHOLINE3,N(4)-Ethenodeoxycytidine2,6-Diamino-9-(2-hydroxyethoxymethyl)purine4-Hydroxy-2H-pyran-3-carboxaldehydeOxymorphoneTyramineMitomycinSabiporidePyroglutamic AcidTrinexapac-ethylDebrisoquineL-Felinine5-Methyl-1H-BenzotriazoleFlazineVanylglycolCytidine 2'-phosphate7-Hydroxyoctanoic acidSebacic acidDihydrojasmonePressinoic acidLeu Thr Ala1,3,5-Triazine-2,4-diamine(+/-)-2-Hydroxy-4-(methylthio)butanoic acidBis(4-nitrophenyl) hydrogen phosphateOctanoateBioepidermAnthralinTryptophanamideAtractylenolide IIIBuntanineGly Phe GlyPodophyllotoxin glucosideCyclo(his-pro)Indoleacetic acidKynurenine3-Hydroxyoctanoic acid(R)-3-Amino-5-(methylthio)pentanoic AcidChavicol6-Hydroxypentadecanedioic acidNoreugenin5,7-Dihydroxyflavone1-PyrrolineCorchoionol C 9-glucosideCedazuridineDeoxyguanosine(2E)-Decenoyl-ACPL-Threo-3-Phenylserine1-Hydroxy-2,2,5,5-tetramethylpyrrolidine-3-carboxamideAnisatin3-(Octyloxy)propan-1-amineN-AcetylmuramateHexadecenal2',3'-DideoxyadenosineIndole-3-acetamideTirofiban4-Amino-3-hydroxybutyrateN-lactoyl-MethionineGlutaminylglutaminePro Val AlaFlavin adenine dinucleotide (FAD)Pro Ala Leu3-Oxododecanoic acidN-Docosahexaenoyl LysineNeoisoastilbin2-Aminopurine1,3,5-TriazineMG(i-19:0/0:0/0:0)Incadronic acidN6-(1,2-Dicarboxyethyl)-AMPPhenytoin methylcatechol1-Pyrroline-5-carboxylic acidHistamineMiltefosineChenodeoxycholylarginineNicotinic AcidSolasodineOxypurinolEpsilon-(Carboxymethyl)lysineBeta-ThujaplicinLeonurine5'-Deoxyadenosine9-OctadecenamideDimethyltriazenoimidazole carboxamide(3S,3'S,5R,5'R,6R)-3,6-Epoxy-5,6-dihydro-3',5,8'-trihydroxy-beta,kappa-caroten-6'-onePterineCincassiol B2-(Ethylamino)ethanolIle LeuAzelaic acidN-[[5-(2,5-dichlorophenyl)furan-2-yl]methyl]-2-piperazin-1-ylethanamineAlpha-Terpineol propanoateAcetyl-Ser-Asp-Lys-ProImexon2-Aminobutan-1-olDeoxyadenosine monophosphateLeu Pro PheN-Acetyl-b-glucosaminylamineDefibrotide(3beta,22E,24R)-Ergosta-4,6,8(14),22-tetraen-3-ol3'-AMPTryptophyl-AsparagineGlycolaldehyde2-Aminobenzoic AcidIsoleucyl-thiazolidineCyclopropanecarboxylic acidS-LactoylglutathioneDeoxycytidineP-AminophenazoneAcetoleinTyphasterolLubiprostonePro Glu LeuMetabonomic, assay, Metabonomics, MSR., Metabolomic, determination, chemical analysisMetabonomic, assay, Metabonomics, MSR., Metabolomic, determination, chemical analysisfalseMetabolomics analysis of the algU mutant strain under hyperosmotic stress.Metabolomics analysis of the algU mutant strain under hyperosmotic 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