MetabolomicsWorkbenchapplication/xmlhttp://www.metabolomicsworkbench.org/rest/study/study_id/ST000546/mwtabprimaryOK200Mass SpectrometryESIMalariahttp://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST000546Artemisinin resistant:Uinfected red blood cells | PfKelch13 mutation:ControlArtemisinin resistant:Resistant | PfKelch13 mutation:C580YArtemisinin resistant:Sensitive | PfKelch13 mutation:WTArtemisinin resistant:Resistant | PfKelch13 mutation:R539TCellsHILIC POSITIVE ION MODE. HILIC NEGATIVE ION MODE.MetabolomicsWorkbenchMetabolomicsPlasmodium FalciparumMonash University[PS(18:1)] 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoserine[SP (16:0)] N-(hexadecanoyl)-sphing-4-enineO-Phospho-L-serineIle-ThrPA(34:2)Leu-ProPE(P-40:4)VinylacetylglycineRiboflavinCys-Leu-Cys-TyrIle-Lys-SerIle-LysL-PipecolateThiamin diphosphateStearoylcarnitinePG(38:6)SM(d34:1)N-acetyl -D- glucosaminitolL-HistidineL-gamma-glutamyl-L-valineNicotinate D-ribonucleosideAla-Asn-ProLys-ValD-GlyceratePE(P-40:5)Ala-Asp-Gly-ArgCMP-2-aminoethylphosphonatePIP(36:1)GMPAsp-Ser-SerPE(30:4)SlaframineL-Proline[FA trihydroxy(4:0)] 2,3,4-trihydroxy-butanoic acid(6R)-6-(L-Erythro-1,2-Dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterinHercyninepsicoselysineAla-Glu-Ala-GluN2-(D-1-Carboxyethyl)-L-lysinePhenolsulfonphthalein2-Amino-9,10-epoxy-8-oxodecanoic acidFurfural5-Nitro-2-(3-phenylpropylamino)benzoic acidO-Butanoylcarnitine5-AcetamidopentanoatePS(38:5)N2-Succinyl-L-ornithineN-Amidino-L-glutamate3-beta-D-Galactosyl-sn-glycerolAsn-Lys-Gly-ProL-AsparagineN6-Acetyl-L-lysineGlu-ArgPC(32:1)(R,R)-Tartaric acidEpsilon-(gamma-Glutamyl)-lysine[PI(36:0)GlutathioneAsn-Val-Asn-AsnAvenic acid AIcosadienoic acidGlu-Glu-ProTemurinSM(d44:2)dihydrothymidineGammaglutamylornithineSer-SerPS(38:4)2-Dehydro-3-deoxy-D-gluconateSM(d33:1)Ala-Asp-SerOrotate(Fragment)N-Succinyl-L-glutamateN-Acetyl-D-mannosaminolactoneCitrate(S,S)-Np-HistidinylalanineGlu-Ala-Pro(S)-MalateIsolinderanolideFA oxo(19:0)PG(40:5)L-OrnithineADPAsp-Lys-Asp-ProGlycerophosphoglycerolLysoPE(20:0)SuccinyladenosineN-Acetyllactosamine(S)-1-Pyrroline-5-carboxylateAla-Leu-Thr-AlaGlu-Glu-Gln-His3-Carbamoyl-2-phenylpropionaldehydeN5-acetyl-N5-hydroxy-L-ornithine2,3-Bisphospho-D-glycerateLys-Thr-SerPS(38:6)MontecristinLys-HisCyclic 2,3-bisphospho-D-glycerate[FA (22:5)] 7Z,10Z,13Z,16Z,19Z-docosapentaenoic acidGlu-Ala-AspLacCer(d32:1)D-Gluconic acidLysoPC(20:4)Met-SerDihydroferuloylglycineN-Acetyl-D-glucosamine 6-phosphateancymidolImidazole-4-acetaldehydeIndoleaeruginosin ASambutoxingamma-L-Glutamyl-D-alaninePE(15:0/20:0)Phe-ThrKinobscurinoneD-ErythrosePS(40:5)PS(18:0)PS(52:0)3-nitro-2-pentanolAloesin4-Methyl-2-oxopentanoateEPC(d35:1)3,3',4',5,7-Pentahydroxy-8-methoxyflavone2-C-Methyl-D-erythritol 4-phosphateL-beta-aspartyl-L-threonineAsp-GlnGlycochenodeoxycholateLysoPC(O-18:0)Isovalerylglutamicacid[PC(16:1)] 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholineL-TyrosinePI(38:5)N-Acetyl-D-glucosaminate(S)-2-AcetolactateD-Erythrose 4-phosphateDG(P-32:1)6-Phospho-D-gluconateLys-Gly-His(S)-LactateLysoPC(18:1(9Z))L-PhenylalanineGDP-3,6-dideoxy-D-galactosePC(30:0)3,4-Dihydroxy-L-phenylalaninePC(40:5)AmurensineIcosatrienoic acidPG(36:4)[FA oxo(21:0)] 2-oxo-heneicosanoic acidGlu-Ala-ValPE(14:0/20:2(11Z,14Z))Val-Proepsilon-aminocaproamideCMPSM(d36:2)PC(40:6)5-AminolevulinatePI(34:2)Ser-Ser-SerL-beta-aspartyl-L-serineAla-Thr-Asp-AspN4-(Acetyl-beta-D-glucosaminyl)asparaginePsychosineEPC(d38:1)N-Carbamyl-L-glutamateHydroxybutyrylcarnitineCys-Lys-Ser-SerMelibiitolPG(36:3)Acetone cyanohydrinAllogibberic acid2,3-DimethylmaleatePE(38:5)Polyoxyethylene dioleate2-16:0-lysoPGVicinegamma-L-Glutamyl-L-cysteine2-OxobutanoateLys-AsnO-Palmitoyl-R-carnitineAla-Ala-Gln-SerGuanine(S)-AMPA5'-MethylthioadenosineGlycyl-Serine4-(Trimethylammonio)but-2-enoateAcetyl phosphateThr-Ala-ProPG(36:2)Creatinine3-ureidoacrylateAla-Thr-Ala-SerN-Carbamoyl-L-aspartatePyridoxineAla-Lys-Lys-AspDiacetylD-XylonateO-PropanoylcarnitineS-Cysteinosuccinic acidHydroxymethylphosphonateBenzyl sulfatePG(36:1)NAD+sn-glycero-3-Phospho-1-inositol[LysoPC(16:2)] 1-hexadecyl-sn-glycero-3-phosphocholine[PI(18:0)] 1-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)Glutathione disulfideArg-Cys-Cys-Tyrmelibionate2-OxoglutarateSM(d38:1)UDP-N-acetyl-D-galactosamine5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehydePI(36:1)PI(36:2)Ala-Asp-Gly-ProAMCCSulfoacetaldehydeBrunfelsamidineBetaine1-Sinapoyl-D-glucoseL-AlanineLys-ProAsn-Sercis-(homo)3aconitateAla-ProCDP-ethanolamineOrotidinePC(38:5)[FA (5:2)] 2,4-pentadienoic acidAMPLysoPE(18:3)gamma-Glutamyl-Se-methylselenocysteineAsp-Asp-Gln-Pro3,5/4-Trihydroxycyclohexa-1,2-dioneL-Methionine S-oxidePE(38:0)CytidineLys-Ser-TyrIsoquinolineMESLysoPE(18:2)Val-Asp-HisL-LysineL-Glutamate[PG (18:0)] 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Met-Met-AlaDihydroclavaminic acidAla-Gly-SerPhosphinothricinsn-glycero-3-PhosphoethanolaminePE(38:1)2-Deoxy-2,3-dehydro-N-acetylneuraminic acidProcollagen 5-(D-galactosyloxy)-L-lysinePI(36:4)[PI(18:0/20:4)] 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)FA(16:0)Pyridoxine phosphateSphinganineGamma-GlutamylglutamineMycosporine4-Amino-4-deoxychorismateAsp-Trp-Asp-GlnPS(18:0/18:1(9Z))N-D-GlucosylarylaminePE(18:3(6Z,9Z,12Z)/P-18:1(11Z))PI(36:3)Glycerone phosphateAla-Gly-Gly4-AminobutanoateAla-Pro-Ser-SerAsp-Thr-Cys-CysPG(36:5)LysoPE(18:0)Ala-Ala-Asp-TyrSulfatenonulose 9-phosphateL-2-Aminoadipate[FA (20:1)] 11Z-eicosenoic acidL-AspartateL-proline amideN-EthylmaleimidePC(38:4)TaurinePG(34:1)D-FructosePE(36:1)6-deoxy-5-ketofructose-1-phosphateGlu-Ala-GluSM(d18:2/24:1)D-Ribose 5-phosphateL-Threonine5-HydroxytryptophanPhosphoenolpyruvate1-thio-beta-D-glucoseGln-Leu-Lys-TyrPG(34:2)D-Sorbitol[SP] Sphing-4-enine-1-phosphateLysoPA(16:0)L-LeucinePyridoxalMethyl 2-diazoacetamidohexonateSM(d39:1)4-AminobutanalGlycerolMuramic acidN-Acetyl-D-glucosamineAla-Asp-Cys-SerCohibin ANe,Ne dimethyllysineAla-Thr-Thr-Ala[PG (18:1)] 1-(9E-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)1-Deoxy-D-altro-heptulose 7-phosphateCholateOphthalmicacidFA (19:1)PS(34:1)Thiamin monophosphateOrthophosphateP-DPDUDP-glucuronatePE(36:3)FA (20:0)3-MethyleneoxindolePhaeantharineL-Tryptophan2-Hydroxy-1,3-dimethoxy-8,9-methylenedioxycoumestan4-TrimethylammoniobutanoateIle-Lys-Pro[FA (18:1)] 9Z-octadecenoic acidPG(33:1)PS(34:0)Phosphoramidate7,8-H2pterin-6-ylmethyl-l-(4-aminophenyl)-1-deoxy-5-[1-alpha -D- ribofuranosyl 5-phosphate]-D-ribitolSM(d38:2)5-L-GlutamylglycineAsp-Leu-Lys-AspSanguinarinedCMPPantothenate3-deoxy-D-galactoseFumarateoctulose 8-phosphate[ST] (5Z,7E)-9,10-seco-5,7,10(19)-cholestatrieneHexylamineATPL-prolyl-L-glycineGlu-GluD-4'-PhosphopantothenateSM(d41:2)PE(34:3)Kievitone hydrate1,2-Dihydroxy-5-(methylthio)pent-1-en-3-oneCreatineN3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoate[FA (18:3)] 9Z,12Z,15Z-octadecatrienoic acidOleoylcarnitineMethacholineBenzene-1,2,4-triolAla-Val-Asp-Serserinol phosphatedeacetylcolchicineD-Glucose 6-phosphateLysoPA(18:0)Gravacridonetriol glucosideSM(d41:1)L-CystineGln-Met-Met-ThrGlu-Glu-Lys-ProPS(34:2)Glu-Ser-ValDihydrozeatin-O-glucoside4-oxo-4-(3-pyridyl)-butanoate7-Methyl-3-oxooctanoyl-CoA3-Phospho-D-glycerateAsp-ArgAla-Glu-Glu-HisHypoxanthineBergaptolgamma-Glutamyl-gamma-aminobutyraldehydePC(36:4)L-ArginineIle-His-Val4-Hydroxy-4-methylglutamateD-Glucuronate2-OxoglutaramateO-beta-D-Glucopyranosyl-cis-zeatinHypaphorinePI(34:1)Phe-AspL-CysteineGDP-L-fucoseN5-(L-1-Carboxyethyl)-L-ornithineN6,N6,N6-Trimethyl-L-lysineGlu-Ala-Sersn-glycero-3-PhosphocholineThiamin6-Hydroxyl-1,6-dihydropurine ribonucleosideAla-Lys-Asp-GlyTrp-Trp-Tyr-TyrSM(d40:2)Asp-Ser-Tyr-TyrPE(P-36:3)NADP+AdenineAsp-Val-Pro-SerSinalbin3-Cyano-L-alaninePI(34:0)LysoPC(16:0)LysoPC(18:3(6Z,9Z,12Z))HEPESAsp-Gly-ArgL-SerineInosineCyclic ADP-ribose(Z)-4-Hydroxyphenylacetaldehyde-oximePG(34:3)L-CysteateLysoPE(20:4)gamma-thiomethyl glutamateAla-Thr-Ala-AspN-Acetyl-L-phenylalanineN2-(2-Carboxymethyl-2-hydroxysuccinoyl)argininePA(36:4)Hydantoin-5-propionateAla-Glu-Gln-Glusn-Glycerol 3-phosphate(S)-ATPAAla-Leu-Asn-SerN-AcetylmethionineAsn-Thr-Cys-HisGDPLys-GlyAsp-Met-Asp-GlyL-gamma-glutamyl-L-isoleucine5-Guanidino-2-oxopentanoateDieporeticeninxi-4,5-Dihydro-2,4(5)-dimethyl-1H-imidazoleAsn-Asn-AspAsp-Cys-Cys-SerSM(d42:2)LysoPE(20:5)CholesterolsulfateL-CitrullineN-Glycosyl-L-asparagineAsn-Asn-Gln-SerN-Formyl-L-methioninePA(36:3)Ala-Asn-Asn-AspN-dimethylethanolamine3-OxopropanoateL-MethionineThr-Trp-CysMaleamate5-Acetyl-2,4-dimethyloxazole[PE(18:1/16:0)] 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineD-erythro-D-galacto-octitolUDP-glucoseNeuraminic acidNicotinamide1H-Imidazole-4-ethanamineProclavaminic acid(S)-DihydroorotateFA hydroxy(10:0)Ile-AlaPG(54:0)S-Adenosyl-L-methionine3-Methyl-2-oxobutanoic acid[PS(20:4)] 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserineSM(d42:1)Ethanolamine phosphate4-HydroxyphenylacetylglycineAla-SerPS(36:3)Dide-O-methylsimmondsinLys-ThrNG,NG-Dimethyl-L-arginineAsn-ProN2-FructopyranosylarginineN-Acetyl-aspartyl-glutamatePE(24:1(15Z)/15:0)2-AminoacrylatePA(18:1(9Z)/0:0)HemePI(40:5)LysoPC(22:5)Glu-Asp-ValPS(36:2)Lys-SerAla-Lys-Asp-ProAspartyl-L-prolineHistidinyl-HistidinePG(40:6)ADP-riboseD-Sedoheptulose 7-phosphateD-GlucosamineN-(L-Arginino)succinateL-GlutaminePyridoxamine phosphateIle-Cys-GlyCholineConvicine5-6-DihydrouridineL-Lysine 1,6-lactamHistidinyl-AsparagineSM(d44:1)PE(P-38:4)PhosphodimethylethanolamineD-Xylonolactone3-propylphosphoenolpyruvatedibenzothiophene-5-oxideAla-Gly-ProIle-Ser-ValPE(31:4)N2-Acetyl-L-aminoadipateGlu-Thrp-aminobenzoyl glutamateN-Acetyl-L-citrullinePC(34:1)D-Mannitol 1-phosphateAla-Asp-AspN-RibosylhistidineUDP[PC(18:2)] 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineCholine phosphateValganciclovir[PA(16:0/18:1)] 1-hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphateAla-Gly-TyrPS(36:4)Met-Ala-GlyIMPCorydalineIndoleacrylicacidL-beta-aspartyl-L-asparticacidAla-Ala-SerPC(34:2)PE(32:1)Asn-Asp[PE(18:2/18:2)] 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine6,7-Dimethyl-8-(1-D-ribityl)lumazineAla-Ala-Ala-AspAsn-AsnSM(d43:2)CDP-cholineAla-Asp-ProL-beta-aspartyl-L-glutamicacid1-18:2-2-18:2-monogalactosyldiacylglycerol3-Ethylmalate[PI(16:0)] 1-hexadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)3-ButynoateAsp-Phe-Pro-TyrFA (20:4)Asn-Leu-Pro-ProRaffinoseAla-Leu-Lys-AspSucrose monopalmitateNarceinoneAsn-Asp-ProPhosphonoacetaldehydealpha-(2,6-anhydro-3-deoxy-D-arabino-heptulopyranosid)onate 7-phosphateUrocanateFebrifuginePiperidine6-Acetyl-D-glucoseN-hydroxy DAPPE(P-38:5)SM(d43:1)LysoPE(22:5)N-Acetyl-L-glutamate2-amino-3,7-dideoxy-D-threo-hept-6-ulosonateMiroestrolNicotinamide D-ribonucleotideMet-Thr-Aspgamma-L-Glutamyl-L-cysteinyl-beta-alanineAla-Leu-Trp-SerPhosphocreatineN2-(D-1-Carboxyethyl)-L-arginine3-Hydroxy-N6,N6,N6-trimethyl-L-lysineAsn-Met-Thr-Aspinsensitive, resistant, Plasmodiums, Plasmodium <Plasmodium>.iones., Ionen, ion, Ion, ions, ionesfalseMulti-omics based identification of specific biochemical changes associated with PfKelch13-mutant artemisinin resistant PlasmodiumST0005465833