MetabolomicsWorkbenchapplication/xmlhttp://www.metabolomicsworkbench.org/rest/study/study_id/ST002011/mwtabprimary200OKMass SpectrometryESIMalariahttp://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST002011Concentration:10X IC50 | Treatment time:2.5 hours | Parasite Stage:MACS purified TrophConcentration:N/A | Treatment time:N/A | Parasite Stage:MACS purified TrophBloodReversed phase NEGATIVE ION MODE. Reversed phase NEGATIVE ION MODE. Reversed phase NEGATIVE ION MODE.MetabolomicsWorkbenchMetabolomicsPlasmodium FalciparumPennsylvania State UniversityN-acetyl-glucosamine-1/6-phosphateVal-Asp (VD)D-glyceraldehdye-3-phosphateCDPThiamine pyrophosphateGlu-Val (EV)thymidinefructose-1-6-bisphosphateglucose-1-phosphateKynurenic acidKetoleucineglutamateorotidine-5'-phosphatealanine/sarcosineSer-Asp (SD)orotateglucono-lactoneN-carbamoyl-L-aspartateprephenatecytidineUDP-D-glucuronateGMPPro-Thr-Thr (PTT)coenzyme ASer-Ile-Asp (SID)creatinecyclic-AMPdTMPdeoxyribose-phosphatedihydroxy-acetone-phosphateUDP-N-acetyl-glucosamineSer-Asp-Leu (SDL)Geranyl-PPasparagineCystineornithineOctanoyl-CoAquinolinateVal-Asp-Pro-Val-Asn-Phe (VDPVNF)FMNribosedCMPa-ketoglutaratemaleic acidchlorpropamideguanosine4-phosphopantothenatexanthine3-phosphoglyceratexanthosinelipoateTriclosanlactateMyristoyl/tetradecanoyl-CoAfumarate4-Pyridoxic acidHexoseglutathione disulfidedUTPindolePro-Asp (PD)cysteineXanthurenic acidarginineIDP2-Hydroxy-2-methylbutanedioic acidcystathioninethiamine4-phosphopantetheineleucineLeu-Asp (LD)Aminoadipic acidHis-Val-Asp-Asp (HVDD)lysinefolatemethionineN-acetyl-L-ornithinePyrophosphateUMPtyrosineN-acetyl-glutamateNADPHdTTPacetyl-aspartatecGMPD-glucosamine-1/6-phosphatedTDPNicotinic acid mononucleotidehomocysteinethreonine/homoserinephenylalanineNADP+p-hydroxybenzoateFADdGMP/AMPdeoxyguanosineanthranilateUric acidpyruvateDecanoyl-CoAdAMPnicotinateCitraconic acidcarnitinedGDP/ADPnicotinamide mononucleotideS-adenosyl-L-methionine2_3-Diphosphoglyceric acidADP-D-glucoseinosineGTPdCDPS-adenosyl-L-homocysteineCholic acidisoleucinemyo-inositolIle-Asp-Ser (IDS)GDPhypoxanthinesuccinate/Methylmalonic acidPro-Glu-Glu-Lys (PEEK)TetrahydrobiopterinD-gluconateIsopentyl-PPcitrate/isocitrateCMPdGTP/ATPaconitatephosphoenolpyruvatedCTPPro-Val-Asn-Phe (PVNF)ribose-phosphatexanthosine-5-phosphatedephospho-CoAN-acetyl-glutaminedeoxyadenosine4-aminobutyratedeoxyuridineglutamine2-dehydro-D-gluconateNADHpyridoxineS-methyl-5'-thioadenosinehexose-phosphatePyroglutamic acidKynurenineUDP-D-glucoseOctulose BisphosphatepantothenatetryptophanriboflavinPhenol RedAsp-Ala-Leu (DAL)2-keto-isovalerateN-Acetyl-L-alanineribulose-5-phosphateglyceratehistidineNAD+fructose-6-phosphateHydroxyisocaproic acidserinedihydroorotatesn-glycerol-3-phosphateL-arginino-succinateRibose-5-phosphateN-acetyl-glucosamineUTPcholesteryl sulfatePro-Glu-Glu (PEE)6-phospho-D-gluconateDL-Pipecolic AcidaspartateCDP-ethanolamineAcetyllysineUDPAsp-Leu-His (DLH)Atovaquonebiotinoxaloacetate1_3-Bisphosphoglyceric acidtaurineIMPPro-Glu (PE)prolinemalateOctulose 8/1PguaninedATP5-phosphoribosyl-1-pyrophosphatesuccinyl-CoA/methylmalonyl-CoASedoheptulose bisphosphatecitrullineD-glucarateCDP-cholineglutathionep-aminobenzoatecCMPAsp-Leu-Ser (DLS)uridinehydroxyproline/Aminolevulinateguanosine 5'-diphosphate-3'-diphosphateD-erythrose-4-phosphateD-sedoheptulose-1/7-phosphate1-Methyladenosineaspartate (standard)Carbamoyl phosphateadeninevalineacetyl-CoA3-phospho-serineCTPDrugs, antagonists, Antimalarial, inhibitors, Anti-Malarial, human being, Man (Taxonomy), Antimalarial Drug, antimalarials, Activity, 3-benzoxazol-5-yl)-1-isopropyl-1H-pyrazolo(3, Modern, Plasmodium, inhibiteur, Antimalarial Drugs, inhibitor, Antimalarial Agent, human, 4-d)pyrimidin-3-yl)-, Anti Malarial, Human, Drug, Agent, Anti-Malarials, inhibidor, Agents, Homo sapiens, antagonists and inhibitors, humanised mouse, Modern Man, 3-(2-Amino-1, 4-d)pyrimidin-4-amine, falciparums, humanized hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahr mutant mice, Plasmodium (Laverania) falciparum., Anti Malarials, malaria parasite P. falciparum, 5-(4-amino-1-(1-methylethyl)-1H-pyrazolo(3, Plasmodium falciparums, Man, General activity, 2-Benzoxazolamine, Antimalarial Agentsbackward, reversed., reversedfalseThe anticancer human mTOR inhibitor MLN0128/Sapanisertib with potent multistage in vitro antiplasmodium activity and in vivo antimalarial efficacy in a humanised mouse model is an inhibitor of multiple Plasmodium falciparum kinases.ST0020115833