MetabolomicsWorkbenchapplication/xmlhttp://www.metabolomicsworkbench.org/rest/study/study_id/ST002078/mwtabprimaryOK200Mass SpectrometryESIMalariahttp://www.metabolomicsworkbench.org/data/DRCCMetadata.php?Mode=Study&StudyID=ST002078Drug:NDDrug:PoolDrug:MMV1091186Drug:HalofuginoneDrug:TCMDC-124553Drug:OSM-S-106Drug:MMV1081413Drug:MMV1578884Drug:BlankCultured CellsReversed phase NEGATIVE ION MODE. Reversed phase NEGATIVE ION MODE. Reversed phase NEGATIVE ION MODE. Reversed phase NEGATIVE ION MODE.MetabolomicsWorkbenchMetabolomicsPlasmodium FalciparumPennsylvania State UniversityN-acetyl-glucosamine-1/6-phosphate2_3-Diphosphoglyceric acidADP-D-glucoseGTPinosinedCDPVal-Asp (VD)S-adenosyl-L-homocysteineD-glyceraldehdye-3-phosphateisoleucineCDPmyo-inositolThiamine pyrophosphateGDPPro-Glu-Glu-Lys (PEEK)succinate/Methylmalonic acidhypoxanthinethymidinefructose-1-6-bisphosphateglucose-1-phosphatePhenylpropiolic acidglutamateorotidine-5'-phosphateD-gluconatepantetheinealanine/sarcosineSer-Asp (SD)orotatecitrate/isocitrateCMPglucono-lactoneN-carbamoyl-L-aspartatecytidineprephenateUDP-D-glucuronatedGTP/ATPGMPaconitatecoenzyme ASer-Ile-Asp (SID)phosphoenolpyruvatedCTPPro-Val-Asn-Phe (PVNF)ribose-phosphatexanthosine-5-phosphatecyclic-AMPdTMPdihydroxy-acetone-phosphateN-acetyl-glutamineUDP-N-acetyl-glucosamine4-aminobutyrateSer-Asp-Leu (SDL)asparagineglutaminePhenylacetyl-CoACystineornithineOctanoyl-CoANADHpyridoxineS-methyl-5'-thioadenosinehexose-phosphatePyroglutamic acidKynurenineUDP-D-glucoseOctulose BisphosphatepantothenatetryptophanriboflavinPhenol Redthiamine-phosphateAsp-Ala-Leu (DAL)Val-Asp-Pro-Val-Asn-Phe (VDPVNF)FMNribosedCMPa-ketoglutaratemaleic acidchlorpropamideguanosine4-phosphopantothenate3-phosphoglycerateN-Acetyl-L-alanineribulose-5-phosphatexanthosineglyceratelactateMyristoyl/tetradecanoyl-CoANAD+histidinefumarate4-Pyridoxic acidfructose-6-phosphateserinedihydroorotatesn-glycerol-3-phosphateHexoseglutathione disulfidedUTPPro-Asp (PD)L-arginino-succinateRibose-5-phosphateXanthurenic acidUTP6-phospho-D-gluconatePro-Glu-Glu (PEE)arginineIDP2-Hydroxy-2-methylbutanedioic acidthiamineDL-Pipecolic AcidacetylphosphateaspartateCDP-ethanolamine4-phosphopantetheineAcetyllysineUDPAsp-Leu-His (DLH)leucineLeu-Asp (LD)biotin1_3-Bisphosphoglyceric acidHis-Val-Asp-Asp (HVDD)IMPPro-Glu (PE)prolinelysinefolatemalateOctulose 8/1PmethionineN-acetyl-L-ornithineguaninedATPPyrophosphate5-phosphoribosyl-1-pyrophosphateUMPsuccinyl-CoA/methylmalonyl-CoAtyrosineSedoheptulose bisphosphateN-acetyl-glutamateRibose-5-S-homocysteineNADPHD-glucaratedTTPCDP-cholineglutathionep-aminobenzoateacetyl-aspartatecCMPAsp-Leu-Ser (DLS)dTDPNicotinic acid mononucleotidehydroxyproline/Aminolevulinatethreonine/homoserinephenylalanineNADP+FADdGMP/AMPanthranilateD-sedoheptulose-1/7-phosphatepyruvateDecanoyl-CoAdAMPnicotinateaspartate (standard)adenineCitraconic acidvalineacetyl-CoAdGDP/ADPnicotinamide mononucleotide3-phospho-serineCTPthymineIsoleucine tRNA Ligase, Antimalarial, Isoleucine-tRNA, L-Isoleucine:tRNA(Ile) ligase (AMP-forming), Anti-Malarial, Isoleucyl tRNA Synthetase ILES1, Antimalarial Drug, Activity, Biocatalysts, Isoleucyl T RNA Synthetase, Plasmodium, Isoleucyl tRNA Synthetase ILS1, 6.1.1.5, Antimalarial Drugs, Isoleucyl- tRNA Synthetase ILS1, Ile-tRNA, Isoleucyl-tRNA synthetase, Agent, Anti-Malarials, 1, Synthetase, Anti Malarial., Antimalarial Agents, Ile tRNA Ligase, Isoleucyl-tRNA Synthetase ILES1, Drugs, Isoleucyl-tRNA Synthetase, Ile-tRNA Ligase, antimalarials, Synthetase 1, Plasmodium (Laverania) falciparum, IRS, Isoleucyl tRNA Synthetase, Antimalarial Agent, Drug, Isoleucyl-tRNA, Ligase, Enzyme, ILES1, Agents, falciparums, Synthetase ILES1, Biocatalyst, Isoleucyl tRNA Synthetase 1, IleRS, Anti Malarials, malaria parasite P. falciparum, Plasmodium falciparums, Isoleucyl-tRNA Synthetase 1, General activitybackward, reversed., reversedfalseMultiple modes of interfering with the activity of Plasmodium falciparum cytoplasmic isoleucyl-tRNA synthetase illustrate the enzyme is a promising antimalarial target.ST0020785833