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Individuals lacking a functional copy of FUT2 are known as “non-secretors” and display an array of differences in susceptibility to infection and disease, including Crohn disease. To determine whether variation in resident microbial communities with respect to FUT2 genotype is a potential factor contributing to susceptibility, we performed 454-based community profiling of the intestinal microbiota in a panel of healthy subjects and Crohn disease patients and determined their genotype for the primary non-secretor allele in Caucasian populations, W143X (G428A). Consistent with previous studies, we observe significant deviations in the microbial communities of individuals with Crohn disease. Furthermore, FUT2 genotype explains substantial differences in community composition, diversity and structure, and we identified several bacterial species displaying disease-by-genotype associations. This indicates that alterations in resident microbial communities may in part explain the variety of host susceptibilities surrounding non-secretor status and that FUT2 is an important genetic factor influencing host-microbial diversity.ENAMicrobial Community Composition, Community Composition, CROHNS DIS, Granulomatous Colitis, Crohn's disease of colon, Regional, large bowel mucosa, Gastritis Associated with Crohn's Disease, Genotypes., Regional Enteritis, Microbial, Enteritis, Human, Ileocolitis, Ileitis, pediatric Crohn's disease, colonic mucous membrane, Genogroup, Regional Ileitis, Gastritis Associated with Crohn Disease, Crohn disease, granulomatous colitis, Crohns Disease, Inflammatory Bowel Disease 1, Colitis, Crohn's associated gastritis, Terminal Ileitis, Microbial Communities, mucosa of large bowel, Microbiome, Granulomatous Enteritis, Microbiomes, Crohn Disease, Microbial Community Compositions, colon mucous membrane, Microbial Community, Microbial Community Structure, Community Structure, regional enteritis, CROHN DIS, Crohn's Enteritis, colonic mucosa, Composition, Granulomatous, Regional Ileitides, Genogroups, Crohn's disease, mucosa of colon, Terminal, colon mucosa, Microbial Community Structures, Microbiotas, Crohn's Disease, associated, Crohn's disease of large bowel, Human Microbiomes, Community, Human Microbiome0.00.00.00.00.00falseThe colonic mucosa-associated microbiota is influenced by an interaction
of Crohn disease and FUT2 (Secretor) genotype2016-05-202011-09-07PRJEB2668410661