ENA0000Genomicsoral microbiology, Faculty of Dentistry, The University of Hong konghttps://www.ebi.ac.uk/ena/browser/view/PRJNA126155Homo sapiensProteomic analysis of cytokines in unstimulated oropharyngeal secretions. Epstein-barr virus (EBV) is a type 1 carcinogen which causes many cancers in humans. Here we explored the cytokine involvement of the EBV replication process in the oropharynx. Cytokine interactomic profiles were geneerated to understand the involved signalling pathways in HIV infected group and the healthy group. Proteome profilers were used to understand the major cytokine expression levels that are related to infection and immune regulation. Overall design: We analyzed unstimulated oropharyngeal samples (UOPS) from 42 healthy subjects and 72 HIV positive subjects using the R & D Proteome Profiler array panels. No techinical replicates were performed. 14 samples in HIV group without therapy (NHAART group); 58 HIV patients with highly active antiretroviral therapy (HAART group); 42 samples in healthy groupENAHIV Infections, HTLV III LAV Infections, Human immunodeficiency virus infectious disease, HTLV WIII LAV INFECTIONS, HTLV-III Infections, Human immunodeficiency virus infection (disorder), Human immunodeficiency virus disease (disorder), Infections, T-Lymphotropic Virus Type III Infections, HIV Infection, HTLV WIII INFECTIONS, HTLV-III, Human immunodeficiency virus caused disease or disorder., HTLV-III-LAV, Human immunodeficiency virus [HIV] disease, HTLV-III-LAV Infections, EBV, HUMAN IMMUNO VIRUS DIS, Human immunodeficiency virus disease or disorder, Human, HTLV III LAV INFECT, HTLV III INFECT, Human immunodeficiency virus disease, Human immunodeficiency virus infection, HIV infectious disease, Unspecified human immunodeficiency virus [HIV] disease (disorder), [X]Unspecified human immunodeficiency virus [HIV] disease (disorder), Cytokine, HTLV III Infections, T LYMPHOTROPIC VIRUS TYPE III INFECT HUMAN, [X]Human immunodeficiency virus disease (disorder), HTLV-III-LAV Infection, Infection, NOS, HIV, T Lymphotropic Virus Type III Infections, HTLV-III Infection, [X]Human immunodeficiency virus disease, LYMPHOTROPIC VIRUS TYPE III INFECTIONS HUMAN T, HIV INFECT, human immunodeficiency virus, HIV - Human immunodeficiency virus infection, HUMAN IMMUNOdeficiency VIRUS [HIV] INFECTION, [X]Unspecified human immunodeficiency virus [HIV] disease, HIV infection, human immunodeficiency virus infectious diseasehuman being, human., man0.00.00.00.00.00falseHomo sapiensCytokine interactome alterations promote oropharyngeal Epstien-barr virus (EBV) replication and shedding during HIV infection2022-05-122014-02-11PRJNA126155GSE213399606