ENA0000GenomicsMedical and Molecular Genetics, School of Clinical and Experimental Medicine, University of Birminghamhttps://www.ebi.ac.uk/ena/browser/view/PRJNA149485Homo sapiensEpigenetic profiling of tumor DNAs may reveal important new theranostic targets to improve prognosis and treatment of advanced cancer patients. In this study, we performed a genome-wide profile of DNA methylation patterns in sporadic breast tumors by using the HumanMethylation27 BeadChips to assess relationships between DNA methylation changes and patient tumor characteristics. The arrays identified 264 hypermethylated loci/genes present in breast cancer genomes Overall design: This study has used the Illumina HumanMethylation27 BeadChip to assess methylation levels of 39 sporadic ductal carcinomas and 4 additional sporadic ductal carcinoma samples. Four normal breast tissue DNA samples were used as controls that were sourced from the same patient as the 4 additional tumour samples.ENABC, CpG Cluster, CpG-Rich Islands, CpG Island, wide/broad, Genomes, carcinoma of breast, mammary carcinoma, broad, Clusters, CpG, DNA methylation profiling, Islands, CpG-Rich Island, CpG Rich Islands, wide, CpG Clusters, Cluster, breast cancer, breast., cancer of breast, Island, NOS, cancer of the breast, breast carcinoma, carcinoma of the breast, cancer, CpG-Richhuman being, human., man0.00.00.00.00.00falseHomo sapiensGenome-wide DNA methylation profiling of CpG islands in breast cancer2022-05-122014-02-11PRJNA149485GSE33065213639129606