ENA0000GenomicsRheumatology, Boston University School of Medicinehttps://www.ebi.ac.uk/ena/browser/view/PRJNA238310Homo sapiensSystemic sclerosis is associated with skin fibrosis thought mediated by TGFb. This open label clinical trial examines the effect of TGFb inhibition on skin gene expression. Patients 1-9 received two doses 1 mg/kg dose of fresolimumab at baseline and 3 weeks; patients 10-19 received a single 5 mg/kg dose Overall design: Patients with diffuse cutaneous systemic sclerosis within 2 years of first raynauds had skin biopsies before treatment and the 3-4 weeks, 7 weeks and 24 weeks after treatment with fresolimumabENAdermis plus epidermis plus hypodermis, SSc, the integument, region of skin, ho, pun, pelt, Systemic, Otf-11, Skn-li, Sclerosis, M(2)LS1, TGF-beta5, AtrII, Act-r, DPP-C, epidermis, TGFbeta, tgfbeta, Hin-d, Scleroderma (& [systemic sclerosis]), DmelCG9885, DmelCG7904, tgfb5, progressive systemic sclerosis, Progressive systemic sclerosis, integumentum commune, Skn-1a, Dm-DPP, systemic, ced, Dpp, DPP, skin, Biopsies, tgf-beta, M(2)23AB, dlhC, systemic scleroderma, dermoid system, entire skin, PSS - Progressive systemic sclerosis, SS - Systemic sclerosis, systemic Scleroderma, tgfb, Systemic sclerosis (disorder), SKIN, blk, diffuse Scleroderma, skin organ, BMP, Scleroderma syndrome, Otf11, Fam91a1, atrII, GC-1008, AV220772, skin and subcutaneous tissue, Atr, l(3)j5A5, data, Oct-11a, Tgf-r, TGF-b, GZ-402669, diffuse, Punt, TGF-beta, Tg, skin zone, integumental organ, CG9885, lap, CG7904, skin plus hypodermis, skin region, Oct11, Atr88CD, Atr-II, l(2)22Fa, BC033609, PUNT, GC1008., Skin-1a, Systemic sclerosis, l(3)10460, tegument, Skin, l(2)k17036, shv, diffuse sclerosis, transforming growth factor beta, l(2)10638, vertebrate integument, systemic sclerosis, Scleroderma, Thibierge-Weissenbach syndrome, mKIAA0493, Epoc-1, portion of skin, vertebrate epidermis, integument, TGF-B, GZ402669, Put, entire integument, dpd1, PSS (progressive systemic sclerosis), STK-C, dermal systemhuman being, human., man0.00.00.00.00.00falseHomo sapiensExpression data from skin biopsies in pateints with systemic sclerosis treated with anti-TGF-beta, fresolimumab2022-05-122015-06-07PRJNA238310GSE55036260982159606