ENAapplication/xmlprimaryOK2000000GenomicsNIMHhttps://www.ebi.ac.uk/ena/browser/view/PRJNA293909Homo sapiensWhole-genome expression analysis across major mental disorders allows examining disease-specific changes and potential common molecular pathogenic mechanisms. We assessed transcription alterations in schizophrenia (SZ), bipolar disorder (BP) and major depression (MDD) as compared to controls (C) in two relevant regions, hippocampus and dorsolateral prefrontal cortex (DLPFC), and in control tissue, dura, for a large cohort of individuals (total number 470 subjects for hippocampus, 691 for DLPFC and 150 for dura). We found a pattern of downregulation of gene expression in SZ, differences in expression between SZ and BP, and between the regions. 37 genes were differentially expressed in SZ vs C in both DLPFC and Hippocampus. Using qPCR, we validated ALDH1a1, which was downregulated in both regions in SZ. There were no differentially expressed genes in dura.ENAammon gyrus, Horn, Cornu ammonis, SCHIZO NEC-CHR/EXACERB, Ammon, Disorders, Ammon horn fields, schizophrenia, formatio hippocampi, Proper, SCHIZO NEC-SUBCHR/EXACER, ammon horn, schizophrenia 12, Hippocampus Propers, Gene, Ammon Horn, Hippocampal Formation, schizophrenia-1, hippocampus proper, affective disorders, seahorse, unspecified (disorder), Subiculums, Affective Disorders, schizophrenia with or without an affective disorder, mood disorder, Schizophrenia NOS, unspecified, schizophrenia (disease), archipallium, mood disorders, Dementia Praecox, Hippocampal, SCHIZO NOS-CHR/EXACERB, Formations, Other specified types of schizophrenia, SCHIZOPHRENIA NEC-SUBCHR, Schizophrenic disorders (disorder), Mood Disorder, chronic state, SCHIZOPHRENIA NEC-CHR, Schizophrenias, major hippocampus, unspecified state, Mood, Ammon's Horn, subchronic state with acute exacerbation, Unspecified schizophrenia, Cornu Ammonis, subchronic state, Affective Disorder, Subiculum, Hippocampus Proper, Hippocampus, cornu ammonis, SCHIZOPHRENIA NEC-UNSPEC, [X]Schizophrenia, hippocampus proprius, Schizophrenia (disorder), Ammon's, major mood disorders, Ammon's horn, Gene Expressions, Propers, Unspecified schizophrenia (disorder), Schizophrenic, hippocampus (Crosby), susceptibility to, Schizophrenic disorders, CNS - Brain - Hippocampus (MMHCC), Affective, Schizophrenic Disorder, Schizophrenia NOS (disorder), hippocampus major, Expressions, Ammons Horn, SCZD, schizoaffective disorder, in remission, Schizophrenic Disorders, hippocampus, primal cortex, Ammons horn, episodic mood disorder, Disorder, Affective., chronic state with acute exacerbation, Expression, SCHIZOPHRENIA NEC-REMISS, SCHIZOPHRENIA NOS-UNSPEC, Hippocampal Formations, Formation, SCHIZO NOS-SUBCHR/EXACERhuman being, human., man0.00.00.00.00.00falseHomo sapiensGene Expression in Postmortem DLPFC and Hippocampus from Schizophrenia and Mood Disorders2022-05-122015-08-27PRJNA2939099606