ENA0000GenomicsKIRAMShttps://www.ebi.ac.uk/ena/browser/view/PRJNA296090Rattus norvegicusMicroarray analysis in the mouse metastatic tumor after ɣ-irradiation(ɣ-IR): non-irradiated primary tumor vs. radiated primary tumor vs. metastatic tumor after ɣ-irradiation Metastatic tumors in C6-L (rat glioma cells ) xenografted mice were studied after local treatment with fractionated γ-IR. To accurately detect the metastatic nodules after γ-IR, we observed the effect of γ-IR on distant metastatic tumor growth. Metastatic nodules after γ-IR indicated extensive colonization of C6-L cells in the lungs within 6 weeks after γ-IR. Identified and described the molecular events occurring after γ-IR through gene expression profiling to elucidate genetic changes (differentially expressed genes between the γ-IR primary tumors vs. non-γ-IR primary tumors and metastatic lung nodules vs. γ-IR primary tumors). Overall design: We investigated the change of gene expression profile in the γ-IR primary tumors vs. non-γ-IR primary tumors and metastatic lung nodules vs. γ-IR primary tumors in rat glioma (C6-L cell) xenograft model.ENAProfiling, Transcriptome, neoplasia, Monitorings, Gene, neoplastic disease, Imaging, metastatic neoplasm, Gene Expression Profilings, Gene Expression, Differential Display, Transcript Expression Analysis, transcription profiling, neoplastic growth, mRNA Differential Displays, metastatic disease, Transcript Expression Analyses, Gene Expression Pattern Analysis, Gene Expression Monitorings, Analysis, Profilings, metastatic tumour., neoplasm, mRNA Differential Display, gene expression profiling, Gene Expression Monitoring, Transcriptome Profiling, Analyses, mRNA, Molecular, cell process disease, tumor disease, Transcriptome Profilings, neoplasm (disease), Transcriptomics, Differential Displays, Transcript Expression, Transcriptome Analysis, disease of cellular proliferation, Transcriptome Analyses, Monitoring, Gene Expression Analysis, metastatic, Gene Expression Analyses, metastatic tumor, Expression Analysis, tumor, Expression Analyses, other neoplasmbrown rat, rat, Norway rat, Rattus sp. strain Wistar, Mus norvegicus, Rattus rattiscus, Rattus norwegicus, rat <Rattus norvegicus>, rats <Rattus norvegicus>, rats, Gunn rats., Rattus norvegicus800.00.00.00.00.0falseRattus norvegicusDetecting metastatic tumors after γ-irradiation using longitudinal molecular imaging and gene expression profiling of metastatic tumor nodules2022-07-192015-09-25PRJNA296090GSE7311610116