ENA0000GenomicsUCSFhttps://www.ebi.ac.uk/ena/browser/view/PRJNA308823Homo sapiensPurpose: The goal of this study was to compare gene expression patterns in the male and female human cortex Methods: We performed RiboZero Gold (rRNA depleted) 50bp PE RNA-seq in a set of control samples of both sexes to identify sexually dimorphic gene expression patterns. Results: Within these samples, we corroborated findings from a discovery set of RNA-seq data from adult human cortex tissue from the BrainSpan consortium which demonstrated male-biased expression of astrocyte marker genes and a gene co-expression module found to be up-regulated in the adult autistic cortex. Conclusions: These findings suggest that sex-differential risk for autism spectrum disorder is not the result of sex-differential regulation of ASD risk genes, but of naturally occurring sexually dimorphic processes that modulate the impact of risk variants for autism spectrum disorder. Overall design: 13 cerebral cortex samples from 10 individuals (7 samples from 5 males, 6 samples from 5 females). Three Samples are included in this study from Series GSE64018. **PLEASE NOTE: Raw data has been submitted to dbGAP**ENAmale human body, cortex, Controlling, reference sample, female human body, maleate, Males, Whole Transcriptome Shotgun Sequencing, RNA-seq, cortex of organ., (2Z)-but-2-enedioate, Females, female, male, Controlledhuman being, human., man0.00.00.00.00.00falseHomo sapiensRNA-seq of male and female control cortex2022-07-192016-02-25PRJNA308823GSE76852268920049606