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Biology Centerhttps://www.ebi.ac.uk/ena/browser/view/PRJNA318461Mus musculusTo identify mediators of Trp53 independent tumor suppressive functions of Cdkn2aArf in the mouse liver, we set up an in vivo RNAi screen. We compiled a miRNA-based shRNA library targeting upregulated genes in Trp53–/– mouse livers (compared to NrasG12V; Cdkn2aArf–/– livers upon NrasG12V delivery), published p19Arf interaction partners and genes involved in sumoylation. This shRNA library was delivered via transposon-based gene transfer together with NrasG12V into Trp53–/– livers. Seven weeks later we assessed the tumor burden in mice injected with different shRNA library pools via Illumina deep sequencing.ENA3.4.22.-, Resectable malignant neoplasm of liver, hepatoma, NEOPL LIVER, Materials, tumor suppressor, primary tumour of the liver, resectable malignant neoplasm of the liver, Laboratory, antigen NY-CO-13, p53, Mus domesticus, Gene, mini-ICE, CASP-14, adult hepatoma, hepatoblastoma caused by somatic mutation, hepatic, LFS1, House Mouse, hepatocellular carcinoma plus intrahepatic cholangiocarcinoma, Tp53, hepatocellular carcinoma, primary liver cancer, malignant tumour of liver, cell cycle regulator, liver, House, bbl, Mus musculus domesticus, liver cell cancer (hepatocellular carcinoma), tumor suppressor p53, Mice, TP53, primary, not specified as primary or secondary, Hepatic Cancer, Genetic, BCC7, primary malignant neoplasm of Liver, Swiss, liver and intrahepatic bile duct cancer, Cancer of the liver, adult primary hepatocellular carcinoma, Hepatic Neoplasms, liver and intrahepatic biliary tract cancer, Swiss Mice, malignant neoplasm of liver, hepatic cancer, liver Cancer., cancer of liver, Trp53, malignant hepato-biliary neoplasm, Resectable malignant neoplasm of Liver, control of cell cycle progression, primary malignant neoplasm of liver, regulation of progression through cell cycle, regulation of cell cycle progression, hepatocellular, phosphoprotein p53, hepatoblastoma, liver cell carcinoma, carcinoma, TRP53, hepatic neoplasm, negative regulation of cell cycle arrest, Cancer, RNAi screen, cell cycle modulation, cancer of the liver, Hepatic Cancers, cell cycle arrest, primary tumor of the liver, malignant, mouse, primary cancer of liver, liver Cancers, carcinoma of liver cells, malignant liver neoplasm, somatic, Cistrons, liver/hepatobiliary cancer, hepatocellular adenocarcinoma, primary liver carcinoma, positive regulation of cell cycle arrest, liver and intrahepatic biliary tract carcinoma, HCC, Mus, primary carcinoma of the liver cells, arrest of mitotic cell cycle progression, Mini-ICE, modulation of cell cycle progression, Neoplasm, Genetic Materials, carcinoma of liver and IBT, bfy, carcinoma of the liver cells, Genetic Material, hepatocellular cancer, Mus musculus, ca liver - primary, liver and intrahepatic bile duct carcinoma, Caspase-14 subunit p10, cell cycle control, childhood type, primary carcinoma of liver cells, mice, non-resectable primary hepatic malignant neoplasm, Swiss Mouse, House Mice, Caspase-14 subunit p19, Cancers, malignant tumor of liver, MICE, RNAi screening, Laboratory Mice, domesticus, mitotic cell cycle arrest, primary malignant liver neoplasm, neoplasm of liver, cancer of the liver and intrahepatic biliary tract, cancer of liver and intrahepatic biliary tract, Ca liver - primary, Material, carcinoma of liver, P53, regulation of cell cycle arrest, LIVER NEOPL, p44, bhy, Cancer of liver, Cistron, Mouse, liver carcinoma, cancer, liver cancer, Laboratory Mouse, cell cycle regulationstrain, mouse, mouse <Mus musculus>, cultivar, house mouse, ecotype.0.00.00.00.00.00falseMus musculus strain:C57BL/6RNAi screening in Trp53-/- mice to identify tumor suppressor genes in liver cancer2022-05-122016-04-15PRJNA31846110090