ENA0000GenomicsMolecular Biotechnology Center, University of Turinhttps://www.ebi.ac.uk/ena/browser/view/PRJNA323353Homo sapiensEpithelial splicing regulatory protein 1 (ESRP1) is an epithelial cell-specific RBP and splicing factor. Both a tumor suppressor role and a pro-metastatic function of ESRP1 have been reported.Our aim was to clarify the role of ESRP1 in colorectal cancer setting.We employed both loss-of-function and gain-of-function approaches to study the role of ESRP1 in human colorectal tumorigenesis in vitro and in vivo, as well as in the metastatic process in vivo. Overall design: RNA from 4 conditions was analyzed. Every condition is represented by a duplicate.ENAtumor cell migration, nuclear mRNA cis splicing, human being, growth of cell, protein complex, non-developmental growth of a unicellular organism, metabolism resulting in cell growth, via spliceosome, metastasis, proteins, metabolic process resulting in cell growth, protein, neoplasm metastasis, protein-containing complex, splicing, man, human, cell expansion, via U2-type spliceosome, protein polypeptide chains, native protein, epithelial, natural protein, polypeptide chain, non-developmental cell growth, Protein, cellular growth, protein aggregate, cancer metastasis., tumor metastasis, epitheliocytehuman being, human., man0.00.00.00.00.00falseHomo sapiensEpithelial Splicing Regulatory protein 1 promotes human colorectal cancer cell growth and metastasis2022-05-122017-04-19PRJNA323353GSE81894280520209606