ENA0000GenomicsMOUNT SINAI SCHOOL OF MEDICINEhttps://www.ebi.ac.uk/ena/browser/view/PRJNA326149Homo sapiensCardiovascular disease is the leading cause of death in the world, affecting individuals of all ethnicities and nations. Cardiovascular disease and associated metabolic risk factors are heritable, yet the majority of inherited disease risk remains unexplained despite successful mapping of numerous loci through genome-wide association studies. Population genetics and previous candidate gene re-sequencing studies have supported the hypothesis that rare variants likely substantially contribute to both human disease and quantitative traits. This study contains whole genome sequence from over 300 African American participants in the BioMe cohort. Sequence data will allow for rare variant associations which have the potential to identify causal genes and point to new therapeutic targets. Whole genome sequence data allows interrogation of the regulatory variation present in non-coding sequence as well as structural variation, both of which may play a significant... (for more see dbGaP study page.)ENAnon-neoplastic, Comparative Genomics., disease, other disease, human disease, Genomics, Structural, diseases, Comparative, Diseases, Functional, disease or disorder, disorders, condition, disorder, Homo sapiens disease, diseases and disorders, Structural Genomics, common, medical condition, Functional Genomicshuman being, human., man0.00.00.00.00.00falseHomo sapiensNHLBI TOPMed - Centers for Common Disease Genomics (CCDG): The BioMe Biobank at Mount Sinai2021-01-082016-06-19PRJNA3261499606