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of Miamihttps://www.ebi.ac.uk/ena/browser/view/PRJNA378764Homo sapiensIn order to identify the processes altered in T regulatory cells (Treg) by Zoledronic acid (ZA), we examined RNA expression by RNA-seq in Treg treated with and without ZA. We identified gene expression alterations in ZA-treated Treg that were essential to Treg function. Overall design: Human T regulatory cells isolated from healthy donors (n=6) were cultured overnight with IL-2 and OKT3 (anti-CD3) in the presence or absence of ZA. RNA sequencing (Illumina HiSeq2500) was performed to identify differential gene expression induced by ZA treatment of Treg.ENAmalignant metastatic neoplasm., 2-(Imidazol-1-yl)-1-hydroxyethylidene-1, biological signaling, dTAF[[II]]230, TAF[[II]]250, d230, CGP 42'446, metastatic malignant neoplasm, Il-2, metastatic cancer, Zoledronate, malignant, CGP 42446A, TAF200, l(3)84Ab, dTAFII250, BG:DS00004.13, function, TAFII-250, CGP 42446, TAF250/230, EfW1, Client, Cell, metastatic neoplasm, dTAF230, dmTAF[[II]]230, TAFII250, TCGF, IL-2, dmTAF1, Taf230, p230, Nfat, TAF[[II]]250/230, TFIID, CGP-42'446, Zoledronic Acid Anhydrous, lymphokine, Zometa, TAF250, interleukin-2 receptor ligand, Taf[[II]]250, NF-AT5, Taf200, Aldesleukin, CGP42'446, dTAF[[II]]250, TAF[[II]]230, aldesleukin, TFIID TAF250, cel, cell, CGP42446, 1-bisphosphonic acid, Taf1p, TAF[II]250, CGP-42446, CG17603, TAF[[II]], signalling, dTAF250, TonEBP, DmelCG17603, signalling process, Taf250, Patient, T-cell growth factor, SR3-5, signaling process, Clients, IL2, TAF, TAF230, single organism signaling, TAF1human being, human., man0.00.00.00.00.00falseHomo sapiensZoledronic acid inhibits NFAT and IL-2 signaling pathways in regulatory T cells and diminishes their suppressive function in patients with metastatic cancer2022-05-122017-06-28PRJNA378764GSE96075289200019606