ENA0000GenomicsGenome Spatial Organization, Institute of Gene Biology Russian Academy of Sciencehttps://www.ebi.ac.uk/ena/browser/view/PRJNA414786Homo sapiensThe paper reports data on measuring whole-genome DNA methylation using an Illumina 450K Methylation BeadChip platform for isogenic induced pluripotent stem cells (iPSCs) derived from fibroblasts of a healthy donor and a PARK-associated Parkinson's disease patient via integrating (lentiviral transfection) and non-integrating (Sendai virus infection) reprogramming. Data on whole-genome methylation of neurons generated by differentiation of the iPSCs were also presented. The iPSCs were reprogrammed using the four Yamanaka’s factors: OCT4 (POU5F1), SOX2, KLF4, and cMYC. The data evidence that there are no significant differences in whole-genome methylation of iPSCs produced by various methods. Overall design: Bisulphite converted DNA from the 12 samples were hybridised to the Illumina HumanMethylation450 BeadChipENAHuman Induced Pluripotent Stem Cells., Fibroblast-Derived IPS Cells, mouse embryonic fibroblast, Fibroblast Derived Induced Pluripotent Stem Cells, Fibroblast-Derived IPS Cell, Genomes, Induced Pluripotent Stem Cell, IPS, Cells, Fibroblast-Derived Induced Pluripotent Stem Cells, Fibroblast-Derived IPS, Fibroblast Derived IPS Cells, hiPSC, methylation, primary dermal fibroblast, Human Induced Pluripotent Stem Cell, Fibroblast-Derived, Methylations, IPS Cell, IPS Cells, Fibroblast, CellHuman Induced Pluripotent Stem Cells., Fibroblast-Derived IPS Cells, mouse embryonic fibroblast, Fibroblast Derived Induced Pluripotent Stem Cells, Fibroblast-Derived IPS Cell, Genomes, Induced Pluripotent Stem Cell, IPS, Cells, Fibroblast-Derived Induced Pluripotent Stem Cells, Fibroblast-Derived IPS, Fibroblast Derived IPS Cells, hiPSC, methylation, primary dermal fibroblast, Human Induced Pluripotent Stem Cell, Fibroblast-Derived, Methylations, IPS Cell, IPS Cells, Fibroblast, Cell0.00.00.00.00.00falseWhole-Genome Methylation Profile of Fibroblast-Derived Isogenic Induced Pluripotent Stem CellsWhole-Genome Methylation Profile of Fibroblast-Derived Isogenic Induced Pluripotent Stem Cells2022-05-282017-10-20PRJNA414786GSE105093295526169606